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ENDOCRINOLOGY (149 journals)                     

Showing 1 - 134 of 134 Journals sorted alphabetically
AACE Clinical Case Reports     Hybrid Journal   (Followers: 5)
Acta Diabetologica     Hybrid Journal   (Followers: 17)
Adipositas - Ursachen, Folgeerkrankungen, Therapie     Hybrid Journal   (Followers: 1)
Advances in Chronic Kidney Disease     Hybrid Journal   (Followers: 15)
Advances in Diabetes and Metabolism     Open Access   (Followers: 22)
Advances in Endocrinology     Open Access   (Followers: 7)
AJP Endocrinology and Metabolism     Hybrid Journal   (Followers: 25)
American Journal of Kidney Diseases     Hybrid Journal   (Followers: 53)
Annales d'Endocrinologie     Hybrid Journal   (Followers: 2)
Applied Physiology, Nutrition and Metabolism     Hybrid Journal   (Followers: 36)
Best Practice & Research Clinical Endocrinology & Metabolism     Hybrid Journal   (Followers: 15)
BMC Endocrine Disorders     Open Access   (Followers: 8)
Case Reports in Endocrinology     Open Access   (Followers: 3)
Clinical Diabetes     Full-text available via subscription   (Followers: 40)
Clinical Diabetes and Endocrinology     Open Access   (Followers: 20)
Clinical Endocrinology     Hybrid Journal   (Followers: 42)
Clinical Medicine Insights : Endocrinology and Diabetes     Open Access   (Followers: 29)
Clinical Nutrition Insight     Full-text available via subscription   (Followers: 13)
Clinical Reviews in Bone and Mineral Metabolism     Hybrid Journal  
Comprehensive Psychoneuroendocrinology     Open Access  
Current Opinion in Endocrine and Metabolic Research     Hybrid Journal   (Followers: 2)
Current Opinion in Endocrinology, Diabetes and Obesity     Hybrid Journal   (Followers: 48)
Dermato-Endocrinology     Open Access   (Followers: 2)
Diabesity     Open Access   (Followers: 3)
Diabetes & Metabolic Syndrome: Clinical Research & Reviews     Hybrid Journal   (Followers: 27)
Diabetes & Metabolism     Hybrid Journal   (Followers: 72)
Diabetes, Obesity and Metabolism     Hybrid Journal   (Followers: 250)
Diabetes/Metabolism Research and Reviews     Hybrid Journal   (Followers: 63)
Diabetology & Metabolic Syndrome     Open Access   (Followers: 8)
Discover Oncology     Open Access   (Followers: 1)
Domestic Animal Endocrinology     Hybrid Journal   (Followers: 6)
Dubai Diabetes and Endocrinology Journal     Open Access  
Egyptian Journal of Obesity, Diabetes and Endocrinology     Open Access   (Followers: 1)
Endocrine     Hybrid Journal   (Followers: 11)
Endocrine and Metabolic Science     Open Access   (Followers: 2)
Endocrine Connections     Open Access   (Followers: 4)
Endocrine Disruptors     Open Access  
Endocrine Journal     Open Access   (Followers: 13)
Endocrine Pathology     Hybrid Journal   (Followers: 7)
Endocrine Practice     Hybrid Journal   (Followers: 58)
Endocrine Regulations     Open Access  
Endocrine Research     Hybrid Journal   (Followers: 3)
Endocrine Reviews     Full-text available via subscription   (Followers: 44)
Endocrine, Metabolic & Immune Disorders - Drug Targets     Hybrid Journal   (Followers: 1)
Endocrine-Related Cancer     Full-text available via subscription   (Followers: 2)
Endocrinología, Diabetes y Nutrición (English Edition)     Hybrid Journal   (Followers: 2)
Endocrinology     Full-text available via subscription   (Followers: 50)
Endocrinology and Metabolism Clinics of North America     Full-text available via subscription   (Followers: 28)
Endocrinology, Diabetes & Metabolism     Open Access  
Endocrinology, Diabetes & Metabolism Case Reports     Open Access  
Endocrinology, Obesity and Metabolic Disorders     Full-text available via subscription   (Followers: 6)
Endokrynologia Polska     Open Access   (Followers: 2)
European Journal of Endocrinology     Full-text available via subscription   (Followers: 40)
European Thyroid Journal     Full-text available via subscription   (Followers: 3)
Experimental and Clinical Endocrinology & Diabetes     Hybrid Journal   (Followers: 24)
Experimental and Clinical Endocrinology & Diabetes Reports     Open Access   (Followers: 4)
Expert Opinion on Drug Metabolism & Toxicology     Hybrid Journal   (Followers: 15)
Expert Review of Endocrinology & Metabolism     Hybrid Journal   (Followers: 7)
Frontiers in Clinical Diabetes and Healthcare     Open Access  
Frontiers in Endocrinology     Open Access   (Followers: 5)
Frontiers in Neuroendocrine Science     Open Access  
Frontiers in Neuroendocrinology     Hybrid Journal   (Followers: 10)
General and Comparative Endocrinology     Hybrid Journal   (Followers: 4)
Growth Hormone & IGF Research     Hybrid Journal   (Followers: 14)
Gynakologische Endokrinologie     Hybrid Journal  
Gynecological Endocrinology     Hybrid Journal   (Followers: 5)
Hormone and Metabolic Research     Hybrid Journal   (Followers: 16)
Hormone Research in Paediatrics     Full-text available via subscription   (Followers: 16)
Hormones : International Journal of Endocrinology and Metabolism     Hybrid Journal  
Hormones and Behavior     Hybrid Journal   (Followers: 12)
Indian Journal of Endocrinology and Metabolism     Open Access   (Followers: 4)
International Journal of Clinical Endocrinology and Metabolism     Open Access   (Followers: 1)
International journal of endocrine oncology     Open Access  
International Journal of Endocrinology     Open Access   (Followers: 3)
International Journal of Endocrinology     Open Access   (Followers: 1)
International Journal of Endocrinology and Metabolism     Open Access   (Followers: 3)
International Journal of Obesity     Hybrid Journal   (Followers: 90)
International Journal of Osteoporosis and Metabolic Disorders     Open Access   (Followers: 1)
International Journal of Pediatric Endocrinology     Open Access   (Followers: 11)
JIMD Reports     Open Access  
Journal für Gynäkologische Endokrinologie/Österreich     Hybrid Journal  
Journal für Klinische Endokrinologie und Stoffwechsel : Austrian Journal of Clinical Endocrinology and Metabolism     Hybrid Journal  
Journal of Bone and Mineral Metabolism     Hybrid Journal   (Followers: 5)
Journal of Clinical and Translational Endocrinology     Open Access  
Journal of Clinical and Translational Endocrinology Case Reports     Open Access   (Followers: 2)
Journal of Clinical Endocrinology & Metabolism     Full-text available via subscription   (Followers: 133)
Journal of Developmental Origins of Health and Disease     Hybrid Journal   (Followers: 2)
Journal of Diabetes and Endocrinology     Open Access   (Followers: 7)
Journal of Diabetes and Endocrinology Assocation of Nepal     Open Access  
Journal of Diabetes and Metabolic Disorders     Open Access   (Followers: 8)
Journal of Diabetes Science and Technology     Hybrid Journal   (Followers: 13)
Journal of Diabetology     Open Access   (Followers: 1)
Journal of Endocrinological Investigation     Full-text available via subscription   (Followers: 7)
Journal of Endocrinology     Full-text available via subscription   (Followers: 13)
Journal of Endocrinology and Metabolism     Open Access   (Followers: 5)
Journal of Endocrinology and Reproduction     Hybrid Journal  
Journal of Endocrinology, Metabolism and Diabetes of South Africa     Open Access   (Followers: 8)
Journal of Inborn Errors of Metabolism and Screening     Open Access  
Journal of Molecular Endocrinology     Full-text available via subscription   (Followers: 5)
Journal of Neuroendocrinology     Hybrid Journal   (Followers: 8)
Journal of Pineal Research     Hybrid Journal   (Followers: 1)
Journal of Renal and Hepatic Disorders     Open Access  
Journal of Restorative Medicine     Open Access  
Journal of Social Health and Diabetes     Open Access   (Followers: 1)
Journal of the ASEAN Federation of Endocrine Societies     Open Access  
Kidney International     Hybrid Journal   (Followers: 52)
Kidney Research Journal     Open Access   (Followers: 6)
L'Endocrinologo     Hybrid Journal  
Metabolic Brain Disease     Hybrid Journal   (Followers: 1)
Metabolic Syndrome and Related Disorders     Hybrid Journal   (Followers: 5)
Metabolism     Hybrid Journal   (Followers: 11)
Molecular and Cellular Endocrinology     Hybrid Journal   (Followers: 8)
Molecular Metabolism     Open Access   (Followers: 9)
Nature Reviews Endocrinology     Full-text available via subscription   (Followers: 60)
Neuroendocrinology     Full-text available via subscription   (Followers: 8)
Nigerian Endocrine Practice     Full-text available via subscription  
Nutrition in Clinical Practice     Hybrid Journal   (Followers: 43)
Open Journal of Endocrine and Metabolic Diseases     Open Access   (Followers: 1)
Psychoneuroendocrinology     Hybrid Journal   (Followers: 14)
Reproductive Biology and Endocrinology     Open Access   (Followers: 3)
Reproductive Endocrinology     Open Access   (Followers: 1)
Reviews in Endocrine and Metabolic Disorders     Hybrid Journal   (Followers: 2)
Revista Argentina de Endocrinología y Metabolismo     Open Access  
Revista Cubana de Endocrinología     Open Access  
Revista Venezolana de Endocrinología y Metabolismo     Open Access  
Sri Lanka Journal of Diabetes Endocrinology and Metabolism     Open Access  
The Endocrinologist     Full-text available via subscription   (Followers: 6)
The Lancet Diabetes and Endocrinology     Full-text available via subscription   (Followers: 161)
Therapeutic Advances in Endocrinology and Metabolism     Open Access   (Followers: 5)
Thyroid     Hybrid Journal   (Followers: 11)
Thyroid Research     Open Access   (Followers: 3)
Thyroid Research and Practice     Open Access   (Followers: 3)
Trends in Endocrinology & Metabolism     Full-text available via subscription   (Followers: 19)
Vitamins & Hormones     Full-text available via subscription   (Followers: 1)

           

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Revista Cubana de Endocrinología
Number of Followers: 0  

  This is an Open Access Journal Open Access journal
ISSN (Print) 0864-4462 - ISSN (Online) 1561-2953
Published by SciELO Homepage  [672 journals]
  • Calidad de vida relacionada con salud en mujeres con síndrome de
           ovario poliquístico

    • Abstract: RESUMEN Introducción: El concepto de calidad de vida relacionada con la salud pretende que el bienestar de los pacientes sea un punto importante para ser considerado tanto en su tratamiento como en el sustento de vida. En el caso de las mujeres con el síndrome de ovario poliquístico, los estudios al respecto han demostrado que existe una afectación directa en su calidad de vida. Objetivo: Evaluar la calidad de vida relacionada con la salud de mujeres con el síndrome de ovario poliquístico mediante el cuestionario PCOSQ. Métodos: Se realizó un estudio transversal en 84 mujeres con diagnóstico de menos de tres meses de síndrome de ovario poliquístico, en el período de septiembre de 2019 a marzo de 2020. Se les aplicó el cuestionario Health-Related Quality of Life Questionnaire (PCOSQ), for women with Polycystic Ovary Syndrome, validado, traducido al español y sometido a un pilotaje previo. Resultados: Los valores medios de cada dominio fueron: Emociones, 3,83; Vello corporal, 4,27; Peso 4,20; Infertilidad, 3,87 y Problemas menstruales, 3,83. De acuerdo a la valoración global de la calidad el 47,6 % estuvo en la categoría de baja, el 42,9 % en media y el 9,5 % en alta. Conclusiones: El padecer el síndrome de ovario poliquístico afecta la calidad de vida relacionada con la salud de estas mujeres. Se debe tener en cuenta estas afectaciones para tener una visión integradora, y proveer atención en este sentido siempre que se requiera.ABSTRACT Introduction: The concept of quality of life related to health intends that the well-being of patients be considered an important point both in their treatment and in the sustenance of life. In the case of women with polycystic ovary syndrome, studies concerning this aspect show results that quality of life is affected. Objective: To assess the quality of life in health, according to the perspective of women with polycystic ovary syndrome by means of questionnaire PCOSQ. Methods: A cross-sectional study was carried out in 84 women with a diagnosis of less than three months of polycystic ovary syndrome in the period from September 2019 to March 2020. The patients were applied the Polycystic Ovary Syndrome Quality of Life questionnaire (PCOSQ), validated and translated into Spanish, as well as subjected to prior piloting. Results: The mean values of each domain were 3.83 (emotions), 4.27 (body hair), 4.20 (weight), 3.87 (infertility problems), and 3.83 (menstrual problems). Regarding the distribution of patients based on the global assessment of their quality of life according to this specific questionnaire, 47.6% were in the low category, 42.9% were in the average category, and 9.5% were in the high category. Conclusions: Polycystic ovary syndrome affects the health-related quality of life of these women. These effects must be taken into account to have an integrative vision and provide care in this regard whenever it is required.
       
  • Factores de riesgo cardiovascular en familiares de primer grado de mujeres
           con síndrome de ovario poliquístico

    • Abstract: RESUMEN Introducción: El síndrome de ovario poliquístico es una entidad que, más allá de las afectaciones reproductivas que lo caracterizan, constituye un factor de riesgo de enfermedad cardiovascular. Esto último, adquiere mayor relevancia debido a que ha aumentado en la mujer que padece el síndrome y también en sus familiares. Objetivo: Demostrar que los familiares de primer grado de las mujeres con el síndrome de ovario poliquístico tienen mayor frecuencia de trastornos del metabolismo hidrocarbonado, dislipidemia y resistencia a la insulina. Métodos: Se realizó un estudio descriptivo transversal con 36 familiares de primer grado de mujeres con y sin síndrome de ovario poliquístico. Se les realizó un examen físico para comprobar el peso, la talla y la tensión arterial para descartar hipertensión en el momento de la inclusión. Resultados: La media del índice HOMA-IR en el grupo de estudio fue de 3,3 y en el de control 2,4. La prueba de tolerancia a la glucosa de 2 horas diagnosticó una glucosa alterada en ayunas a 9 familiares, 5 (55,6 %) del grupo de estudio y 4 (44,4 %), del grupo control. Hubo 7 familiares a los que se les detectó una tolerancia a la glucosa alterada, 6 (85,7 %) familiares de mujeres con el síndrome y 1 (14,3 %), del grupo control. Conclusiones: Los factores de riesgo cardiovasculares clásicos estudiados son más frecuentes en los familiares de mujeres con síndrome de ovario poliquístico que en los familiares de mujeres sin dicha enfermedad.ABSTRACT Introduction: Polycystic ovary syndrome is an entity that, beyond the reproductive affectations that characterize it, constitutes a risk factor for cardiovascular disease. This aspect acquires greater relevance because the associated entity is not only increasing among the women who suffers from the syndrome, but also among their family members. Objective: To show that first-degree relatives of women with polycystic ovary syndrome present a higher frequency of carbohydrate metabolism disorders, dyslipidemia and insulin resistance. Methods: A cross-sectional and descriptive study was carried out with 36 first-degree relatives of women with and without polycystic ovary syndrome. They underwent physical examination to check their weight, height and blood pressure, in order to rule out hypertension at the time of inclusion. Results: The mean HOMA-IR index was 3.3 in the study group and 2.4 in the control group. The two-hour glucose tolerance test permitted to diagnose impaired fasting glucose in nine relatives, five (55.6%) from the study group and four (44.4%) from the control group. Seven relatives were reported with impaired glucose tolerance, six (85.7%) relatives of women with the syndrome and one (14.3%) from the control group. Conclusions: The classic cardiovascular risk factors studied are more frequent in the relatives of women with polycystic ovary syndrome than in the relatives of women without this disease.
       
  • Enfermedad cardiovascular subclínica en familiares de mujeres con
           síndrome de ovario poliquístico y su asociación con la resistencia a la
           insulina

    • Abstract: RESUMEN Introducción: Se ha demostrado que los familiares de mujeres con síndrome de ovario poliquístico tienen mayor frecuencia de factores de riesgo cardiovascular, tales como la resistencia a la insulina, la diabetes mellitus tipo 2, la dislipidemia y la hipertensión arterial. Por ende, estas personas presentan un mayor riesgo de desarrollar enfermedad cardiovascular. Objetivo: Determinar la frecuencia de enfermedad cardiovascular subclínica en familiares de primer grado de mujeres con y sin síndrome de ovario poliquístico y su relación con la resistencia a la insulina. Métodos: Se realizó un estudio descriptivo transversal en 36 familiares de primer grado de mujeres con el síndrome de ovario poliquístico e igual cantidad en familiares de mujeres sin la enfermedad. Ninguno de los miembros de ambos grupos tenía antecedentes de diabetes mellitus, prediabetes, dislipidemia e hipertensión arterial, ni obesidad. Para llevar a cabo la comparación de los resultados de las pruebas realizadas fueron pareados a razón de 1:1, por edad ± 5 años, parentesco, sexo e índice de masa corporal. Resultados: Con enfermedad cardiovascular subclínica hubo 21 familiares, 15 del grupo de estudio (71,4 %) y del grupo control el 28,6 %, (p < 0,05). De la totalidad de familiares del grupo de estudio, con resistencia a la insulina el 65,0 % presentó enfermedad cardiovascular subclínica. En el grupo control, ninguno de los pacientes con insulinemia en ayunas normal tuvo enfermedad cardiovascular subclínica. Conclusiones: La enfermedad cardiovascular subclínica es más frecuente en los familiares de mujeres con síndrome de ovario poliquístico y la resistencia a la insulina se asocia de forma significativa a este padecimiento en ambos grupos.ABSTRACT Introduction: Relatives of women with polycystic ovary syndrome have been show to present a higher frequency of cardiovascular risk factors, such as insulin resistance, type 2 diabetes mellitus, dyslipidemia and arterial hypertension. Therefore, these people have a higher risk for developing cardiovascular disease. Objective: To determine the frequency of subclinical cardiovascular disease in first-degree relatives of women with and without polycystic ovary syndrome and its relationship with insulin resistance. Methods: A cross-sectional and descriptive study was carried out with 36 first-degree relatives of women with polycystic ovary syndrome and with the same number of relatives of women without the disease. None of the members of both groups had a history of diabetes mellitus, prediabetes, dyslipidemia, high blood pressure, or obesity. To carry out the comparison of the results of the tests carried out, they were matched at a 1: 1 ratio, by age ± 5 years, relationship, sex and body mass index. Results: There were 21 relatives with subclinical cardiovascular disease, 71.4% of which belonged to the study group, why 28.6% belonged to the control group (P < 0.05). Of the total family members of the study group, with insulin resistance, 65.0% had subclinical cardiovascular disease. In the control group, with normal fasting insulinemia, none has subclinical cardiovascular disease. Conclusions: Subclinical cardiovascular disease is more frequent in the relatives of women with polycystic ovary syndrome, while insulin resistance is significantly associated with this condition in both groups.
       
  • Calidad de vida en mujeres con el síndrome de ovario poliquístico,
           según el cuestionario WHOQOL-BREF

    • Abstract: RESUMEN Introducción: El síndrome de ovario poliquístico se caracteriza clínicamente por trastornos menstruales, infertilidad anovulatoria, hiperandrogenismo clínico y bioquímico. Con frecuencia se asocia a diabetes mellitus tipo 2, hipertensión arterial, dislipidemia y riesgo de enfermedad cardiovascular. Objetivo: Evaluar la calidad de vida de mujeres con diagnóstico de síndrome de ovario poliquístico, según el cuestionario WHOQOL-BREF. Métodos: Se realizó un estudio transversal en el periodo de septiembre de 2019 a marzo de 2020, que incluyó a 84 mujeres con diagnóstico del síndrome de menos de tres meses. Se les aplicó el cuestionario para evaluar la calidad de vida denominado WHOQOL-BREF, elaborado por la Organización Mundial de la Salud. Resultados: La valoración de la calidad de vida global para el 20,2 % fue poca, el 15,5 % refiere que es mala y el 8,3 % de los pacientes dijo estar muy insatisfecho con su estado de salud. La media de la puntuación de este ítem fue 2,81. La media de la calidad de vida global de las mujeres estudiadas fue 85,2. De acuerdo con la calidad de vida global categorizada como baja, media o alta, en el primer caso hubo un 14,3 %, el 72,6 % estuvo dentro de la calificación media y solo el 13,1 % tuvo una calidad de vida alta. Conclusiones: El cuestionario demostró una afectación moderada de la calidad de vida en las mujeres con la enfermedad, sobre todo en facetas de la dimensión física. Por tanto, consideramos importante incluir el estudio de los aspectos relacionados con su calidad de vida en aras de tener una atención más integral.ABSTRACT Introduction: Polycystic ovary syndrome is clinically characterized by menstrual disorders, anovulatory infertility, as well as clinical and/or biochemical hyperandrogenism. It is frequently associated with type 2 diabetes mellitus, arterial hypertension, dyslipidemia, and risk of cardiovascular disease. Objective: To assess quality of life of women diagnosed with polycystic ovary syndrome, from their perspective and using a general questionnaire. Methods: A cross-sectional study was carried out in the period from September 2019 to March 2020, which included 84 women with a diagnosis of the syndrome for less than three months. The questionnaire to assess quality of life called WHOQOL-BREF, prepared by the World Health Organization, was applied to them. Results: Assessment of global quality of life for 20.2% was low, 15.5% refer that it is bad, and 8.3% of the patients expressed that they were very dissatisfied with their health status. The mean score for this item was 2.81. The mean value of global quality of life of the women studied was 85.2. Consistent with the global quality of life categorized as low, medium or high, in the first case there was 14.3%. 72.6% were within the average rating, and only 13.1% presented a high value for quality of life. Conclusions: The questionnaire showed a moderate impact on the quality of life in women with the disease, especially in aspects of the physical dimension. Therefore, we consider it important to include the study of aspects related to their quality of life in order to have a more comprehensive care.
       
  • Tasa de mortalidad de personas con pie diabético en La Habana durante
           el periodo 2010-2015

    • Abstract: RESUMEN Introducción: Se define como pie diabético toda infección, úlcera o destrucción tisular del pie asociada a neuropatía y/o enfermedad vascular periférica de miembros inferiores en personas con diabetes. Objetivo: Determinar la tasa de mortalidad en personas con pie diabético en La Habana durante el período 2010-2015, así como las causas y las variables sociodemográficas de los fallecidos. Método: Estudio observacional, descriptivo y retrospectivo. Se revisó el registro de fallecidos por diabetes mellitus en La Habana como causa básica de muerte de los años comprendidos del 2010 al 2015, Se analizaron las variables edad, sexo, causa básica de muerte, amputaciones y municipio de procedencia. Los resultados se expresaron en frecuencias absolutas, relativas y tasas por 100 000 habitantes. Resultados: La tasa de mortalidad en personas con pie diabético fue de 3,07/105 habitantes. El año de mayor mortalidad fue el 2010 (10,41 %) y el de menor fue el 2011 (7,34 %). Predominaron las mujeres (56 %) y los mayores de 70 años (66,5 %). En el 48,5 % de los casos se reportaron amputaciones. Las causas directas de muerte más frecuente fueron: la sepsis (34,5 %), el tromboembolismo pulmonar (32,2 %) y la bronconeumonía (21,1 %). Los municipios con menores tasas de fallecidos fueron La Habana Vieja y Arroyo Naranjo. Conclusiones: La tasa de mortalidad en personas con pie diabético en el período 2010-2015 tuvieron una tendencia a la disminución. Las cifras más elevadas se observaron en la edad y en el sexo femenino. Las infecciones, el tromboembolismo pulmonar y la bronconeumonía fueron las causas de muerte directa más importantes.ABSTRACT Introduction: Mortality due to diabetes mellitus may rise due to an increase in its prevalence and the risk of chronic complications. Objective: To determine the mortality rate in people with diabetic foot in Havana during the 2010-2015 period, as well as the causes and sociodemographic variables of the deceased. Methods: Observational, descriptive and retrospective study. The registry of deaths from diabetes mellitus as the basic cause of death from 2010 to 2015 was reviewed. The variables age, sex, basic cause of death, amputations and municipality of origin were analyzed. The results were expressed in absolute and relative frequencies, as well as in rates per hundred thousand inhabitants. Results: The mortality rate in people with diabetic foot was 3.07/105 inhabitants. The year with the highest mortality was 2010 (10.41%) and the year with the lowest value was 2011 (7.34%). Women (56%) and those aged over seventy years (66.5%) predominated. In 48.5% of the cases accounted for amputations. The most frequent direct causes of death were sepsis (34.5%), pulmonary thromboembolism (32.2%) and bronchopneumonia (21.1%). The municipalities with the lowest death rates were La Habana Vieja and Arroyo Naranjo. Conclusions: Mortality rates in people with diabetic foot in the 2010-2015 period tended to decrease. The highest figures were observed in geriatric ages and among women. Infections, pulmonary embolism and bronchopneumonia were the most important direct causes of death.
       
  • LECISAN® y sus potencialidades terapéuticas para el abordaje
           farmacológico de la obesidad

    • Abstract: RESUMEN Introducción: La obesidad se ha identificado como un estado crónico de inflamación sistémica conocido como lipoinflamación. En los últimos tiempos ha cobrado relevancia el descubrimiento de moléculas clave que actúan como blancos terapéuticos, así como sus conexiones y mecanismos existentes. Por otra parte, es sabido lo difícil que es la obtención de nuevos fármacos naturales como alternativas o terapias complementarias en enfermedades crónicas no transmisibles como la obesidad y las dislipemias. El LECISAN® destaca como candidato por sus potencialidades. Objetivos: Valorar los resultados de investigaciones preclínicas y clínicas que avalan el uso del LECISAN®. Métodos: Se realizó una revisión sistemática y crítica de las evidencias de impacto de los efectos de la lecitina de soya. Se consultaron artículos publicados preferentemente en los últimos diez años en las bases de datos EBSCO, Google Scholar, Latindex, Redalyc, DOAJ, Dialnet, WorldCat, LILACS, SciELO y OATD. Conclusiones: El LECISAN® es un producto natural que rebasa el contexto de su empleo como suplemento nutricional, pero requiere nuevas investigaciones en el campo de la farmacología. Resultan contradictorios y poco concluyentes los resultados referentes a sus posibles efectos y usos.ABSTRACT Introduction: Obesity has been identified as a chronic state of systemic inflammation known as lipoinflammation. In recent times, the discovery of key molecules acting as therapeutic targets, as well as their connections and existing mechanisms, has gained relevance. On the other hand, it is known how difficult it is to obtain new natural drugs as alternatives or complementary therapies in chronic noncommunicable diseases such as obesity and dyslipidemias. LECISAN® stands out as a candidate, for its potentialities. Objective: To assess the results of preclinical and clinical investigations that support the use of LECISAN®. Methods: A systematic and critical review of evidence about the impact of the effects of soy lecithin was carried out. Articles published preferably in the last ten years were consulted, from the EBSCO, Google Scholar, Latindex, Redalyc, DOAJ, Dialnet, WorldCat, LILACS, SciELO and OATD databases. Conclusions: LECISAN® is a natural product that goes beyond the context of its use as a nutritional supplement, but requires new research in the field of pharmacology. The results regarding its possible effects and uses are contradictory and inconclusive, based on hypotheses that relate an emulsifying action with the phospholipids present in the mixture, the antioxidant effects with isoflavones, the anti-inflammatory effects with the polyunsaturated fatty acids that regulate lipid metabolism, as well as the activation of the phospholipase A2 system with the consequent production of inflammatory cytosines.
       
 
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