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HEMATOLOGY (160 journals)                     

Showing 1 - 151 of 151 Journals sorted alphabetically
Acta Angiologica     Open Access   (Followers: 2)
Acta Haematologica     Full-text available via subscription   (Followers: 23)
Acta Haematologica Polonica     Open Access  
Adipocyte     Open Access  
Advances in Hematology     Open Access   (Followers: 13)
Africa Sanguine     Full-text available via subscription  
American Journal of Hematology     Hybrid Journal   (Followers: 52)
Anemia     Open Access   (Followers: 6)
Annals of Hematology     Hybrid Journal   (Followers: 15)
Archives of Hematology Case Reports and Reviews     Open Access  
Arteriosclerosis, Thrombosis and Vascular Biology     Full-text available via subscription   (Followers: 29)
Artery Research     Hybrid Journal   (Followers: 4)
Artificial Cells, Nanomedicine and Biotechnology     Hybrid Journal   (Followers: 4)
ASAIO Journal     Hybrid Journal   (Followers: 2)
Best Practice & Research Clinical Haematology     Hybrid Journal   (Followers: 5)
Blood     Hybrid Journal   (Followers: 290)
Blood Advances     Open Access   (Followers: 6)
Blood and Lymphatic Cancer : Targets and Therapy     Open Access   (Followers: 7)
Blood Cancer Journal     Open Access   (Followers: 18)
Blood Cells, Molecules, and Diseases     Hybrid Journal   (Followers: 8)
Blood Coagulation & Fibrinolysis     Hybrid Journal   (Followers: 60)
Blood Pressure     Open Access  
Blood Pressure Monitoring     Hybrid Journal   (Followers: 1)
Blood Purification     Full-text available via subscription   (Followers: 6)
Blood Reviews     Hybrid Journal   (Followers: 26)
BMC Hematology     Open Access   (Followers: 7)
BMJ Open Diabetes Research & Care     Open Access   (Followers: 29)
Bone Marrow Transplantation     Hybrid Journal   (Followers: 17)
British Journal of Diabetes & Vascular Disease     Open Access   (Followers: 21)
British Journal of Haematology     Hybrid Journal   (Followers: 60)
British Journal of Primary Care Nursing - Cardiovascular Disease, Diabetes and Kidney Care     Full-text available via subscription   (Followers: 10)
Canadian Journal of Diabetes     Hybrid Journal   (Followers: 28)
Case Reports in Hematology     Open Access   (Followers: 10)
Clinical and Applied Thrombosis/Hemostasis     Open Access   (Followers: 32)
Clinical Diabetes     Full-text available via subscription   (Followers: 39)
Clinical Diabetes and Endocrinology     Open Access   (Followers: 20)
Clinical Lymphoma & Myeloma     Full-text available via subscription   (Followers: 2)
Clinical Lymphoma Myeloma and Leukemia     Hybrid Journal   (Followers: 5)
Clinical Medicine Insights : Blood Disorders     Open Access   (Followers: 1)
Conquest : The Official Journal of Diabetes Australia     Full-text available via subscription   (Followers: 3)
Current Angiogenesis     Hybrid Journal   (Followers: 1)
Current Diabetes Reports     Hybrid Journal   (Followers: 24)
Current Diabetes Reviews     Hybrid Journal   (Followers: 27)
Current Hematologic Malignancy Reports     Hybrid Journal   (Followers: 2)
Current Opinion in Hematology     Hybrid Journal   (Followers: 20)
Cytotherapy     Full-text available via subscription   (Followers: 2)
Der Diabetologe     Hybrid Journal   (Followers: 2)
Diabetes     Full-text available via subscription   (Followers: 404)
Diabetes aktuell     Hybrid Journal   (Followers: 3)
Diabetes and Vascular Disease Research     Hybrid Journal   (Followers: 20)
Diabetes Care     Full-text available via subscription   (Followers: 462)
Diabetes Case Reports     Open Access  
Diabetes Educator     Hybrid Journal   (Followers: 27)
Diabetes Management     Full-text available via subscription   (Followers: 15)
Diabetes Research and Clinical Practice     Hybrid Journal   (Followers: 71)
Diabetes Spectrum     Full-text available via subscription   (Followers: 16)
Diabetes Technology & Therapeutics     Hybrid Journal   (Followers: 50)
Diabetes Therapy     Open Access   (Followers: 23)
Diabetic Foot & Ankle     Open Access   (Followers: 10)
Diabetic Medicine     Hybrid Journal   (Followers: 143)
Diabetologia     Hybrid Journal   (Followers: 201)
Diabetologia Kliniczna     Hybrid Journal  
Diabetologie und Stoffwechsel     Hybrid Journal   (Followers: 2)
Egyptian Journal of Haematology     Open Access  
eJHaem     Open Access  
European Journal of Haematology     Hybrid Journal   (Followers: 16)
Experimental Hematology     Hybrid Journal   (Followers: 6)
Experimental Hematology & Oncology     Open Access   (Followers: 6)
Expert Review of Hematology     Hybrid Journal   (Followers: 5)
Fluids and Barriers of the CNS     Open Access   (Followers: 1)
Global Journal of Transfusion Medicine     Open Access   (Followers: 1)
Haematologica - the Hematology journal     Open Access   (Followers: 33)
Haemophilia     Hybrid Journal   (Followers: 66)
Hematologia     Full-text available via subscription   (Followers: 3)
Hematología     Open Access  
Hematology     Open Access   (Followers: 15)
Hematology Reports     Open Access   (Followers: 4)
Hematology, Transfusion and Cell Therapy     Open Access   (Followers: 2)
Hematology/Oncology and Stem Cell Therapy     Open Access   (Followers: 6)
Hemodialysis International     Hybrid Journal   (Followers: 3)
Hepatitis Monthly     Open Access   (Followers: 3)
Immunohematology : Journal of Blood Group Serology and Molecular Genetics     Hybrid Journal   (Followers: 1)
Indian Journal of Hematology and Blood Transfusion     Hybrid Journal   (Followers: 2)
Info Diabetologie     Full-text available via subscription   (Followers: 1)
InFo Hämatologie + Onkologie : Interdisziplinäre Fortbildung von Ärzten für Ärzte     Full-text available via subscription  
Integrated Blood Pressure Control     Open Access  
International Blood Research & Reviews     Open Access  
International Journal of Clinical Transfusion Medicine     Open Access   (Followers: 3)
International Journal of Diabetes in Developing Countries     Hybrid Journal   (Followers: 6)
International Journal of Diabetes Research     Open Access   (Followers: 8)
International Journal of Hematologic Oncology     Open Access   (Followers: 2)
International Journal of Hematology     Hybrid Journal   (Followers: 4)
International Journal of Hematology Research     Open Access   (Followers: 2)
International Journal of Hematology-Oncology and Stem Cell Research     Open Access   (Followers: 2)
International Journal of Laboratory Hematology     Hybrid Journal   (Followers: 25)
Iraqi Journal of Hematology     Open Access  
JMIR Diabetes     Open Access  
Journal of Blood Disorders & Transfusion     Open Access   (Followers: 3)
Journal of Applied Hematology     Open Access   (Followers: 2)
Journal of Blood Medicine     Open Access   (Followers: 1)
Journal of Cerebral Blood Flow & Metabolism     Hybrid Journal   (Followers: 3)
Journal of Diabetes     Open Access   (Followers: 20)
Journal of Diabetes and its Complications     Hybrid Journal   (Followers: 25)
Journal of Diabetes and Metabolic Disorders     Open Access   (Followers: 8)
Journal of Diabetes Investigation     Open Access   (Followers: 12)
Journal of Diabetes Mellitus     Open Access   (Followers: 5)
Journal of Diabetes Research     Open Access   (Followers: 13)
Journal of Diabetes Research     Open Access   (Followers: 9)
Journal of Hematological Malignancies     Open Access  
Journal of Hematology     Open Access   (Followers: 2)
Journal of Hematology and Transfusion Medicine     Open Access   (Followers: 1)
Journal of Hematopathology     Hybrid Journal   (Followers: 3)
Journal of Hypo & Hyperglycemia     Partially Free  
Journal of Pediatric Hematology/Oncology     Hybrid Journal   (Followers: 8)
Journal of Social Health and Diabetes     Open Access   (Followers: 1)
Journal of Thrombosis and Haemostasis     Hybrid Journal   (Followers: 80)
Journal of Thrombosis and Thrombolysis     Hybrid Journal   (Followers: 35)
Journal of Transfusion Medicine     Full-text available via subscription  
Kidney and Blood Pressure Research     Open Access   (Followers: 4)
Leukemia     Hybrid Journal   (Followers: 22)
Leukemia and Lymphoma     Hybrid Journal   (Followers: 12)
Leukemia Research     Hybrid Journal   (Followers: 8)
Leukemia Research Reports     Open Access   (Followers: 1)
Leukemia Supplements     Full-text available via subscription  
Mediterranean Journal of Hematology and Infectious Diseases     Open Access  
Nederlands Tijdschrift voor Diabetologie     Hybrid Journal  
Nutrition & Diabetes     Open Access   (Followers: 20)
Oncohematology     Open Access   (Followers: 1)
Open Diabetes Journal     Open Access  
Open Hematology Journal     Open Access   (Followers: 1)
Open Hypertension Journal     Open Access  
Open Journal of Blood Diseases     Open Access  
Pediatric Blood & Cancer     Hybrid Journal   (Followers: 8)
Pediatric Hematology Oncology Journal     Open Access   (Followers: 3)
Peritoneal Dialysis International     Hybrid Journal  
Platelets     Hybrid Journal   (Followers: 3)
Practical Diabetes     Hybrid Journal   (Followers: 7)
Primary Care Diabetes     Hybrid Journal   (Followers: 26)
Research & Reviews : Journal of Oncology and Hematology     Full-text available via subscription   (Followers: 1)
Research and Practice in Thrombosis and Haemostasis     Open Access   (Followers: 1)
Revista Cubana de Hematología, Inmunología y Hemoterapia     Open Access  
Seminars in Hematology     Hybrid Journal   (Followers: 12)
Seminars in Thrombosis and Hemostasis     Hybrid Journal   (Followers: 45)
Thalassemia Reports     Open Access   (Followers: 1)
The Lancet Haematology     Full-text available via subscription   (Followers: 38)
Therapeutic Advances in Hematology     Hybrid Journal  
Thrombosis & Haemostasis     Hybrid Journal   (Followers: 140)
Thrombosis Research     Hybrid Journal   (Followers: 47)
Transfusionsmedizin - Immunhämatologie, Hämotherapie, Immungenetik, Zelltherapie     Hybrid Journal  
Transplantation and Cellular Therapy     Hybrid Journal   (Followers: 13)
Veins and Lymphatics     Open Access   (Followers: 1)

           

Similar Journals
Journal Cover
Egyptian Journal of Haematology
Number of Followers: 0  

  This is an Open Access Journal Open Access journal
ISSN (Print) 1110-1067 - ISSN (Online) 2090-9268
Published by Medknow Publishers Homepage  [448 journals]
  • Stress effect of COVID-19 pandemic among Egyptian children and adolescents
           with malignancy: a single-center experience

    • Authors: Heba G.A Elraheem Ali, Asmaa W.A Aziz, Reham I Abdelmageed, Safa M Sayed
      Pages: 195 - 200
      Abstract: Heba G.A Elraheem Ali, Asmaa W.A Aziz, Reham I Abdelmageed, Safa M Sayed
      The Egyptian Journal of Haematology 2021 46(4):195-200
      Background Thoughts and feelings of stress and worry are common for any person facing the challenges of a serious illness. Aim The aim was to assess the effect of COVID-19 on the psychological well-being of patients with malignancy compared with age-matched and sex-matched controls and to compare the psychological effect of COVID-19 with the psychological effect of malignancy among the patient group. Patients and methods This case–control study included 46 participants diagnosed with malignancy who were compared with 45 healthy age-matched and sex-matched individuals serving as a control group. Their ages were more than 8 years. All patients and controls were subjected to history taking with an emphasis on age, sex, educational level, history of chronic medical illness in the family, disease status, physical symptoms during the last 14 days, and data about COVID-19 infection. The psychological effect was measured using the Children’s Revised Impact of Event Scale Crises-13. Results Mean age of the patient group was 11.76±3.31 years. There were 30 male and 16 female in the case group, who were compared with 45 age-matched and sex-matched healthy children and adolescents. There was a significantly higher prevalence of psychological stressful effect among the healthy children group than the oncological pediatric patients. The psychological effect related to malignancy diagnosis was significantly higher than the psychological effect related to COVID-19. Conclusion COVID-19 pandemic is a stressful event; however, the psychological effect related to cancer diagnosis among the oncological patients showed a higher stressful effect.
      Citation: The Egyptian Journal of Haematology 2021 46(4):195-200
      PubDate: Wed,18 May 2022
      DOI: 10.4103/ejh.ejh_43_21
      Issue No: Vol. 46, No. 4 (2022)
       
  • Evaluation of plasma protein C and antithrombin levels in patients with
           tuberculosis

    • Authors: Hagar G Shahin, Dina A Fouad, Mervat A.A Alfeky
      Pages: 201 - 207
      Abstract: Hagar G Shahin, Dina A Fouad, Mervat A.A Alfeky
      The Egyptian Journal of Haematology 2021 46(4):201-207
      Background Tuberculosis (TB) is a global health problem and thromboembolic complications, when occurring, are often fatal, with no proven markers to predict. The most common type is latent tuberculosis infection (LTBI); however, patients can develop active TB disease and become infectious. Managing LTBI properly can prevent active disease evolution, and exclusion of active TB is the main primary question in LTBI management. Protein C (PC) and antithrombin (AT) are natural anticoagulants with anti-inflammatory properties, so they are suggested to have a role in hypercoagulability due to inflammatory processes. Aim To correlate PC and AT levels in TB patients with patients’ coagulable and clinical state. Patients and methods Sixty patients (20 pretreatment, 20 posttreatment active TB, and 20 LTBI) and 20 normal-controls were included. Activity levels of PC and AT were measured and correlated to patients’ coagulable and clinical states, and routine laboratory results. Results Activity levels of PC and AT are significantly low in active TB, increasing with treatment, and normal in LTBI. No thromboembolic events were detected in all patients included, so correlation with PC and AT could not be verified. Conclusion Active TB is associated with hypercoagulable state, with low activity levels of PC and AT. Both proteins are suggested to be used as adjuvant markers of activation of LTBI and during their pretreatment assessment, together with monitoring therapeutic response in patients with active TB.
      Citation: The Egyptian Journal of Haematology 2021 46(4):201-207
      PubDate: Wed,18 May 2022
      DOI: 10.4103/ejh.ejh_55_21
      Issue No: Vol. 46, No. 4 (2022)
       
  • A retrospective analysis of clinicopathological features and treatment
           

    • Authors: Sohaila Fatima, Abdulrahman Alshehri, Wajih A Siddiqui, Shahid Aziz
      Pages: 208 - 213
      Abstract: Sohaila Fatima, Abdulrahman Alshehri, Wajih A Siddiqui, Shahid Aziz
      The Egyptian Journal of Haematology 2021 46(4):208-213
      Introduction Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm that shows the characteristic formation of the Philadelphia chromosome, containing the BCR-ABL1 fusion gene. Objective The experience with patients with CML regarding clinical features, as well as efficacy and safety of tyrosine kinase inhibitors (TKIs) as a treatment for CML was analyzed in this study. Materials and methods A retrospective study was conducted in patients diagnosed with CML regarding clinicomorphological features and treatment outcome in a tertiary hospital located in southwest Saudi Arabia from July 2004 to June 2020. The study population included patients diagnosed with CML who were older than 12 years. Patients younger than 12 years, BCR-ABL-negative CML, and other myeloproliferative neoplasm were not included in the study. Medical records of patients were reviewed, and data were collected. Results During this period, 80 patients with CML were treated. The mean age was 41.6 years, with a slight male predominance. Overall, 90% of patients presented with abdominal discomfort and fatigue. Chronic phase represented 90% of all cases, with 55.5% showing intermediate-risk category of the Sokal score. Patients receiving a first-line treatment with first-generation TKI represented 42.5% and second-generation TKIs represented 52.5%. Complete hematological response was noted in 96.2% of patients after 3 months of treatment, and a major molecular response was seen in 77.2% of patients after 12 months of treatment. Adverse events (AEs) of TKI noted were 16 (20%), of which 81.2% were grade 1. They were as follows: pleural effusion in four (5%), neutropenia in two (2.5%), bone marrow suppression in four (5%), and skin itching in six (7.5%) in patients with dasatinib, contributing to 56.2% of all AEs. Overall, four (5%) patients were in treatment-free remission. Mean survival period in chronic phase CML was found to be 15.4 years, whereas in advanced phase CML was 4.7 years. Conclusion Our study revealed that patients with CML were predominantly middle aged with a slight male preponderance. Most patients presented in the chronic phase, with the Sokal score in the intermediate-risk category. Patients were treated upfront with TKIs with a significant number receiving second-generation TKIs. First-generation TKIs had lesser AEs as compared with second-generation TKIs, but these toxicities were mild.
      Citation: The Egyptian Journal of Haematology 2021 46(4):208-213
      PubDate: Wed,18 May 2022
      DOI: 10.4103/ejh.ejh_65_21
      Issue No: Vol. 46, No. 4 (2022)
       
  • Identification of subpopulations of multipotent progenitor cells in
           hematopoietic stem-cell transplant patients using flow cytometry

    • Authors: Amera H Elsayed, Soha R Youssef, Mohamed M Moussa, Yasmine N Elsakhawy, Dalia D Salem, Mariam K Youssef
      Pages: 214 - 226
      Abstract: Amera H Elsayed, Soha R Youssef, Mohamed M Moussa, Yasmine N Elsakhawy, Dalia D Salem, Mariam K Youssef
      The Egyptian Journal of Haematology 2021 46(4):214-226
      Background The implemented flow-cytometric protocol for enumeration of CD34+ cells in bone marrow, peripheral, or cord blood addresses only CD34+ cells, irrespective of their distinct subsets. However, the definition of CD34+ different subsets has gained importance concerning the engraftment kinetics and immune reconstitution, after hematopoietic stem-cell transplantation. Objectives This study aimed to describe and enumerate CD34 subpopulations, using a multicolor flow-cytometric protocol, based on the expression of CD133, SSEA-4, CD38, and CD10, in an attempt to explore the impact of the different CD34 subsets on engraftment kinetics, patient, and graft outcomes. Methods A total of 33 bone marrow transplant (25 autologous and 8 allogenic) Egyptian patients were included. Detailed demographic, clinical, and laboratory data, as well as echocardiography and pulmonary-function tests, were collected from all participants enrolled in the study, before transplantation. All patients were monitored up to 1 year post transplantation, for the development of complications. Discrimination of the distinct stem-cell subsets in the harvest was performed on NAVIOS flow cytometer, using multicolor FCM phenotyping. Results Seven CD34+ hematopoietic stem cell subpopulations were identified in the harvest blood by flow cytometry: the multipotent progenitor (MPP), erythromyeloid progenitor, B-lymphoid progenitor (BLP), multilymphoid progenitor (MLP), lymphomyeloid progenitor (LMPP), granulocyte and macrophage progenitor (GMP), and the late GMP. The MPP was the most frequently encountered subpopulation, whereas the BLP was the least-encountered one. In addition, the % population and absolute count of the late GMP were significantly higher after autologous transplantation (P=0.049 and 0.048, respectively). The absolute count of the MLP was significantly higher after G-CSG + chemotherapy-mobilization technique (P=0.039). Higher absolute count of the MLP in the harvest was associated with longer post-transplant 1-year survival of patients (P=0.025). The % population of the GMP in the harvest was significantly correlated with faster engraftment (P=0.039). However, a higher proportion of the late GMP (P=0.041and 0.028, respectively), along with higher absolute count of the LMPP, has been significantly encountered in patients who developed post-transplant disease relapse (P=0.050). By drawing a receiver-operating characteristic curve, only the size of the MPP population at cutoffs of ≤18.85% and ≤165312, respectively, could be significantly used to predict the persistence of cytopenia at 3 months after transplantation. Conclusion This study found that discrimination and quantification of the different CD34 stem-cell subsets might play a pivotal role for better understanding of engraftment kinetics and prediction of post-transplant graft and patient outcomes.
      Citation: The Egyptian Journal of Haematology 2021 46(4):214-226
      PubDate: Wed,18 May 2022
      DOI: 10.4103/ejh.ejh_69_21
      Issue No: Vol. 46, No. 4 (2022)
       
  • Assessment of Von Willebrand factor antigen and activity levels in
           inflammatory bowel diseases

    • Authors: Alaa Abozied, Yousryeia A Ahmed, Mostafa F. Mohammed Saleh, Hanan Galal, Wael A Abbas
      Pages: 227 - 233
      Abstract: Alaa Abozied, Yousryeia A Ahmed, Mostafa F. Mohammed Saleh, Hanan Galal, Wael A Abbas
      The Egyptian Journal of Haematology 2021 46(4):227-233
      Background There is a close interaction between inflammation and coagulation. Hemostatic abnormalities are common in inflammatory bowel disease (IBD) with higher risk for a hypercoagulable state and prothrombotic conditions. In addition, a few cases of acquired coagulopathy with higher risk of bleeding have been reported. The involved pathophysiologic mechanisms are complex and incompletely understood. Objective This is a case–control study that aimed to assess the levels of Von Willebrand factor (VWF) in IBD as a marker of disease activity and its relation to higher risk of bleeding or thrombotic events. Patients and methods A total of 46 patients with IBD aged 18 years or older were enrolled in the study. After consenting, patients were divided into two groups: one group included 23 patients with active IBD and the other group included 23 patients with inactive IBD. Activity of Crohn’s disease was assessed through the Harvey-Bradshaw index and activity in patients with ulcerative colitis was evaluated with the simple clinical colitis activity index. The white blood cell count, hemoglobin level, platelet count, activated partial thromboplastin time, C-reactive protein, erythrocyte sedimentation rate, albumin, fecal calprotectin, VWF antigen level (VWF:Ag), and VWF ristocetin cofactor activity (VWF:RCo) were measured. The VWF:RCo/VWF:Ag ratio was calculated. Results There were significant differences in the mean±SD of vWF antigen and vWF:RCo levels between active IBD group (189.30±62.83 and 101.73±23.42, respectively, P=0.001) and inactive IBD group 177.30±64.90 and 97.08±24.21, respectively, P=0.001). The IBD activity index was correlated with VWF antigen (r=0.78 P=0.001) and VWF:RCo levels (r=0.74 P=0.001). VWF antigen and VWF:RCo were correlated with fecal calprotectin (r=0.65, P=0.001, and r=0.67, P=0.001, respectively). The odds ratio of an elevated vWF antigen greater than 150% was 24 (95% confidence interval: 4.38–131.47) in the group with active IBD compared with the inactive IBD group. The VWF:RCo/VWF:Ag ratio of less than 0.7 which reflects the possibility of acquired Von Willebrand syndrome was detected in five patients (21.7%) with active IBD in comparison with only one patient (4.3%) in the inactive IBD group, with odds ratio of 6.1 (95% confidence interval: 0.65–57.1). Conclusion VWF antigen and activity levels can be used as markers for evaluation of IBD activity. Assessment of VWF in IBD could be significant for better hemostatic control of such patients. Activated coagulation system in IBD is well known; however, precautions for coexisting acquired functional coagulopathy should be considered.
      Citation: The Egyptian Journal of Haematology 2021 46(4):227-233
      PubDate: Wed,18 May 2022
      DOI: 10.4103/ejh.ejh_68_21
      Issue No: Vol. 46, No. 4 (2022)
       
  • Significance of leukocyte β-glucocerebrosidase and plasma
           chitotriosidase in patients with β-thalassemia major

    • Authors: Fadime E Dursun
      Pages: 234 - 242
      Abstract: Fadime E Dursun
      The Egyptian Journal of Haematology 2021 46(4):234-242
      Objective β-thalassemia major (β-TM) is an autosomal-recessive condition with various clinical presentations, including anemia, splenomegaly, and skeletal and cardiac involvement. The aim of this study was to analyze leukocyte β-glucocerebrosidase (β-GBA) levels and plasma chitotriosidase (PCT) activity in patients with β-TM and to determine the significance of these two enzymes in this disease. Patients and methods This study included 40 patients, 18–55 years of age, who were under follow-up for β-TM in our clinic. Physical examination, ECG, echocardiography, laboratory findings, and the results of imaging tests obtained during routine control visits were recorded. Leukocyte β-GBA and PCT activity levels were analyzed in the blood using fluorometric methods. Results The average age of the 40 patients, which included 24 (60%) women and 16 (40%) men, was 28.5±7.8 years. Leukocyte β-GBA levels were below 2.5 nmol/mg/h in 15 patients, and PCT activity was above 200 μmol/l/h in 10 patients. A positive correlation was detected for leukocyte β-GBA enzyme levels with cardiac T2* (P=0.024); however, a negative correlation was detected with intraventricular septum thickness (P=0.029) and left heart posterior wall thickness (P=0.030). Conclusion Lower leukocyte β-GBA levels and higher PCT activity may be present in patients with β-TM. There may be an increase in cardiac iron load, intraventricular septum thickness, and left ventricle posterior wall thickness, especially in patients with lower leukocyte β-GBA levels and higher PCT activity. Therefore, leukocyte β-GBA levels and PCT activity may be associated with cardiac complications in patients with β-TM.
      Citation: The Egyptian Journal of Haematology 2021 46(4):234-242
      PubDate: Wed,18 May 2022
      DOI: 10.4103/ejh.ejh_47_21
      Issue No: Vol. 46, No. 4 (2022)
       
  • Evaluating the rate of blood components discarded at a private transfusion
           facility as a first step toward tailoring wastage

    • Authors: Sidra A Ali, Huma Mansoori, Maria Ali
      Pages: 243 - 248
      Abstract: Sidra A Ali, Huma Mansoori, Maria Ali
      The Egyptian Journal of Haematology 2021 46(4):243-248
      Background and objectives Abstract Transfusion of blood and blood products plays a central role in various life-saving procedures and clinical conditions. Wastage of blood and blood products in a country where concept of voluntary blood donation is still naïve and blood banks strive to fulfill the ongoing requirement is inexcusable. This study focused on collecting the baseline wastage data of various blood products and identifying reasons behind wastage. Materials and methods The study was conducted from January 2018 to December 2019 in a hospital blood bank of a tertiary care center. Retrospective analysis was done on the data retrieved. Wastage rate and potential reasons of wastage of different blood products were analyzed. Results A total of 11 594 U of blood were issued from blood bank during the study duration. Expired platelets were found to be the most frequently wasted blood products (3998/4861). Overall wastage rate as a percentage of issue was 41.9%. Conclusion Blood product wastage in our institute is high, translating to immense financial burden. The study highlighted various key elements and malpractices that contributed to overall wastage. A follow-up study after implementation of corrective measures is planned to regularly monitor wastage of blood and blood products.
      Citation: The Egyptian Journal of Haematology 2021 46(4):243-248
      PubDate: Wed,18 May 2022
      DOI: 10.4103/ejh.ejh_40_20
      Issue No: Vol. 46, No. 4 (2022)
       
  • Alterations in body composition in survivors of childhood acute
           lymphoblastic leukemia

    • Authors: Eman S Hamama, Marwa S El-Sherif, Mohamed A El-Asrar, Sara M Makkeyah
      Pages: 249 - 254
      Abstract: Eman S Hamama, Marwa S El-Sherif, Mohamed A El-Asrar, Sara M Makkeyah
      The Egyptian Journal of Haematology 2021 46(4):249-254
      Introduction We studied the body composition among survivors of childhood acute lymphoblastic leukemia (ALL) as compared to healthy controls. Methods Twenty-nine survivors of childhood ALL and 35 age- and sex-matched healthy controls were evaluated for anthropometric measurements, including weight, height, body mass index (BMI), and waist-to-hip ratio. Body composition was analyzed using Tanita SC-330P scale. Measurement of fasting insulin, glucose, lipids, and serum leptin was done for all participants. Results BMI-standard deviation score (SDS) was significantly higher among the survivor group (mean±SD 0.79±1.2) versus controls (0.25±0.85, P=0.041). Obesity/overweightness were more prevalent among survivors than the control group (34.5% and 17.6%, respectively); however, the difference did not reach statistical significance (P=0.215). There was no difference between both the groups when comparing waist-to-hip ratio, body fat %, fat-free mass %, muscle mass %, and total body water % as well as serum leptin and lipid profile. Among ALL survivors, the overweight/obese group had higher total cholesterol and low-density lipoprotein-cholesterol than survivors with normal BMI-SDS (P=0.0127 and 0.025, respectively), while other variables, including gender, median time from diagnosis, cranial irradiation, serum leptin, were comparable for both the groups. Conclusion ALL survivors are more prone to obesity and altered body composition. Incorporating preventive strategies early into treatment regimens is needed to prevent the development of these metabolic abnormalities.
      Citation: The Egyptian Journal of Haematology 2021 46(4):249-254
      PubDate: Wed,18 May 2022
      DOI: 10.4103/ejh.ejh_38_21
      Issue No: Vol. 46, No. 4 (2022)
       
  • Vancomycin-related thrombocytopenia in neonates: are Sudanese infants more
           prone? Case reports and literature review

    • Authors: Suhair A.R Osman Hassan
      Pages: 255 - 257
      Abstract: Suhair A.R Osman Hassan
      The Egyptian Journal of Haematology 2021 46(4):255-257
      Background With the improvement of neonatal care in the country and survival of the preterm infants and sick neonates, many arising problems are being observed. One of these is the significant presence of neonatal thrombocytopenia and the need for lots of platelet transfusions per an infant. Many neonatal factors can cause thrombocytopenia, but we observed severe, prolonged thrombocytopenia in infants who received specifically vancomycin for sepsis or other medical/surgical conditions. Literature search revealed that vancomycin can cause immune thrombocytopenia by inducing platelet antibodies, though this is scarcely described in neonates. Participants and methods This is a hospital-based longitudinal study held in NICU during February 2017 to February 2019. All admitted neonates (term and preterm) who received vancomycin were involved, but those with maternal thrombocytopenia, systemic lupus erythematosus (SLE), maternal eclampsia/HELLP (Haemolysis, Elevated Liver enzymes, Low Platelets) syndrome, and Intr Uterine Growth Rrestriction (IUGR) were excluded. Results Of 117 infants admitted in this period, 68 infants fulfilled the inclusion criteria. The severe decline in platelet count observed on the second to third day of vancomycin treatment continued throughout the treatment and started to rise 2–3 days after discontinuation. During treatment with vancomycin, platelet transfusion 2–3 times a day was observed not to raise platelet level significantly, but it prevented serious bleeding. Conclusion Vancomycin-induced thrombocytopenia in neonate is a rising new problem in NICUs. The authors may need to add adjunctive intravenous immunoglobulins or methylprednisolone or change the dosing system to smaller frequent doses, given over longer time, to overcome this serious problem.
      Citation: The Egyptian Journal of Haematology 2021 46(4):255-257
      PubDate: Wed,18 May 2022
      DOI: 10.4103/ejh.ejh_19_20
      Issue No: Vol. 46, No. 4 (2022)
       
 
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