Subjects -> MEDICAL SCIENCES (Total: 8185 journals)
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HEMATOLOGY (160 journals)                     

Showing 1 - 151 of 151 Journals sorted alphabetically
Acta Angiologica     Open Access   (Followers: 2)
Acta Haematologica     Full-text available via subscription   (Followers: 23)
Acta Haematologica Polonica     Open Access  
Adipocyte     Open Access  
Advances in Hematology     Open Access   (Followers: 13)
Africa Sanguine     Full-text available via subscription  
American Journal of Hematology     Hybrid Journal   (Followers: 52)
Anemia     Open Access   (Followers: 6)
Annals of Hematology     Hybrid Journal   (Followers: 15)
Archives of Hematology Case Reports and Reviews     Open Access  
Arteriosclerosis, Thrombosis and Vascular Biology     Full-text available via subscription   (Followers: 29)
Artery Research     Hybrid Journal   (Followers: 4)
Artificial Cells, Nanomedicine and Biotechnology     Hybrid Journal   (Followers: 4)
ASAIO Journal     Hybrid Journal   (Followers: 2)
Best Practice & Research Clinical Haematology     Hybrid Journal   (Followers: 5)
Blood     Hybrid Journal   (Followers: 296)
Blood Advances     Open Access   (Followers: 7)
Blood and Lymphatic Cancer : Targets and Therapy     Open Access   (Followers: 7)
Blood Cancer Journal     Open Access   (Followers: 18)
Blood Cells, Molecules, and Diseases     Hybrid Journal   (Followers: 8)
Blood Coagulation & Fibrinolysis     Hybrid Journal   (Followers: 60)
Blood Pressure     Open Access  
Blood Pressure Monitoring     Hybrid Journal   (Followers: 1)
Blood Purification     Full-text available via subscription   (Followers: 6)
Blood Reviews     Hybrid Journal   (Followers: 26)
BMC Hematology     Open Access   (Followers: 7)
BMJ Open Diabetes Research & Care     Open Access   (Followers: 29)
Bone Marrow Transplantation     Hybrid Journal   (Followers: 17)
British Journal of Diabetes & Vascular Disease     Open Access   (Followers: 21)
British Journal of Haematology     Hybrid Journal   (Followers: 60)
British Journal of Primary Care Nursing - Cardiovascular Disease, Diabetes and Kidney Care     Full-text available via subscription   (Followers: 10)
Canadian Journal of Diabetes     Hybrid Journal   (Followers: 28)
Case Reports in Hematology     Open Access   (Followers: 10)
Clinical and Applied Thrombosis/Hemostasis     Open Access   (Followers: 32)
Clinical Diabetes     Full-text available via subscription   (Followers: 39)
Clinical Diabetes and Endocrinology     Open Access   (Followers: 20)
Clinical Lymphoma & Myeloma     Full-text available via subscription   (Followers: 2)
Clinical Lymphoma Myeloma and Leukemia     Hybrid Journal   (Followers: 5)
Clinical Medicine Insights : Blood Disorders     Open Access   (Followers: 1)
Conquest : The Official Journal of Diabetes Australia     Full-text available via subscription   (Followers: 3)
Current Angiogenesis     Hybrid Journal   (Followers: 1)
Current Diabetes Reports     Hybrid Journal   (Followers: 24)
Current Diabetes Reviews     Hybrid Journal   (Followers: 27)
Current Hematologic Malignancy Reports     Hybrid Journal   (Followers: 2)
Current Opinion in Hematology     Hybrid Journal   (Followers: 20)
Cytotherapy     Full-text available via subscription   (Followers: 2)
Der Diabetologe     Hybrid Journal   (Followers: 2)
Diabetes     Full-text available via subscription   (Followers: 411)
Diabetes aktuell     Hybrid Journal   (Followers: 3)
Diabetes and Vascular Disease Research     Hybrid Journal   (Followers: 20)
Diabetes Care     Full-text available via subscription   (Followers: 469)
Diabetes Case Reports     Open Access  
Diabetes Educator     Hybrid Journal   (Followers: 27)
Diabetes Management     Full-text available via subscription   (Followers: 15)
Diabetes Research and Clinical Practice     Hybrid Journal   (Followers: 70)
Diabetes Spectrum     Full-text available via subscription   (Followers: 16)
Diabetes Technology & Therapeutics     Hybrid Journal   (Followers: 50)
Diabetes Therapy     Open Access   (Followers: 23)
Diabetic Foot & Ankle     Open Access   (Followers: 10)
Diabetic Medicine     Hybrid Journal   (Followers: 147)
Diabetologia     Hybrid Journal   (Followers: 206)
Diabetologia Kliniczna     Hybrid Journal  
Diabetologie und Stoffwechsel     Hybrid Journal   (Followers: 2)
Egyptian Journal of Haematology     Open Access  
eJHaem     Open Access  
European Journal of Haematology     Hybrid Journal   (Followers: 16)
Experimental Hematology     Hybrid Journal   (Followers: 6)
Experimental Hematology & Oncology     Open Access   (Followers: 6)
Expert Review of Hematology     Hybrid Journal   (Followers: 5)
Fluids and Barriers of the CNS     Open Access   (Followers: 1)
Global Journal of Transfusion Medicine     Open Access   (Followers: 1)
Haematologica - the Hematology journal     Open Access   (Followers: 33)
Haemophilia     Hybrid Journal   (Followers: 66)
Hematologia     Full-text available via subscription   (Followers: 3)
Hematología     Open Access  
Hematology     Open Access   (Followers: 15)
Hematology Reports     Open Access   (Followers: 4)
Hematology, Transfusion and Cell Therapy     Open Access   (Followers: 2)
Hematology/Oncology and Stem Cell Therapy     Open Access   (Followers: 6)
Hemodialysis International     Hybrid Journal   (Followers: 3)
Hepatitis Monthly     Open Access   (Followers: 3)
Immunohematology : Journal of Blood Group Serology and Molecular Genetics     Hybrid Journal   (Followers: 1)
Indian Journal of Hematology and Blood Transfusion     Hybrid Journal   (Followers: 2)
Info Diabetologie     Full-text available via subscription   (Followers: 1)
InFo Hämatologie + Onkologie : Interdisziplinäre Fortbildung von Ärzten für Ärzte     Full-text available via subscription  
Integrated Blood Pressure Control     Open Access  
International Blood Research & Reviews     Open Access  
International Journal of Clinical Transfusion Medicine     Open Access   (Followers: 3)
International Journal of Diabetes in Developing Countries     Hybrid Journal   (Followers: 6)
International Journal of Diabetes Research     Open Access   (Followers: 8)
International Journal of Hematologic Oncology     Open Access   (Followers: 2)
International Journal of Hematology     Hybrid Journal   (Followers: 4)
International Journal of Hematology Research     Open Access   (Followers: 2)
International Journal of Hematology-Oncology and Stem Cell Research     Open Access   (Followers: 2)
International Journal of Laboratory Hematology     Hybrid Journal   (Followers: 25)
Iraqi Journal of Hematology     Open Access  
JMIR Diabetes     Open Access  
Journal of Blood Disorders & Transfusion     Open Access   (Followers: 3)
Journal of Applied Hematology     Open Access   (Followers: 2)
Journal of Blood Medicine     Open Access   (Followers: 1)
Journal of Cerebral Blood Flow & Metabolism     Hybrid Journal   (Followers: 3)
Journal of Diabetes     Open Access   (Followers: 20)
Journal of Diabetes and its Complications     Hybrid Journal   (Followers: 25)
Journal of Diabetes and Metabolic Disorders     Open Access   (Followers: 8)
Journal of Diabetes Investigation     Open Access   (Followers: 12)
Journal of Diabetes Mellitus     Open Access   (Followers: 5)
Journal of Diabetes Research     Open Access   (Followers: 13)
Journal of Diabetes Research     Open Access   (Followers: 9)
Journal of Hematological Malignancies     Open Access  
Journal of Hematology     Open Access   (Followers: 2)
Journal of Hematology and Transfusion Medicine     Open Access   (Followers: 1)
Journal of Hematopathology     Hybrid Journal   (Followers: 3)
Journal of Hypo & Hyperglycemia     Partially Free  
Journal of Pediatric Hematology/Oncology     Hybrid Journal   (Followers: 8)
Journal of Social Health and Diabetes     Open Access   (Followers: 1)
Journal of Thrombosis and Haemostasis     Hybrid Journal   (Followers: 81)
Journal of Thrombosis and Thrombolysis     Hybrid Journal   (Followers: 35)
Journal of Transfusion Medicine     Full-text available via subscription  
Kidney and Blood Pressure Research     Open Access   (Followers: 4)
Leukemia     Hybrid Journal   (Followers: 22)
Leukemia and Lymphoma     Hybrid Journal   (Followers: 12)
Leukemia Research     Hybrid Journal   (Followers: 8)
Leukemia Research Reports     Open Access   (Followers: 1)
Leukemia Supplements     Full-text available via subscription  
Mediterranean Journal of Hematology and Infectious Diseases     Open Access  
Nederlands Tijdschrift voor Diabetologie     Hybrid Journal  
Nutrition & Diabetes     Open Access   (Followers: 20)
Oncohematology     Open Access   (Followers: 1)
Open Diabetes Journal     Open Access  
Open Hematology Journal     Open Access   (Followers: 1)
Open Hypertension Journal     Open Access  
Open Journal of Blood Diseases     Open Access  
Pediatric Blood & Cancer     Hybrid Journal   (Followers: 8)
Pediatric Hematology Oncology Journal     Open Access   (Followers: 3)
Peritoneal Dialysis International     Hybrid Journal  
Platelets     Hybrid Journal   (Followers: 3)
Practical Diabetes     Hybrid Journal   (Followers: 7)
Primary Care Diabetes     Hybrid Journal   (Followers: 26)
Research & Reviews : Journal of Oncology and Hematology     Full-text available via subscription   (Followers: 1)
Research and Practice in Thrombosis and Haemostasis     Open Access   (Followers: 1)
Revista Cubana de Hematología, Inmunología y Hemoterapia     Open Access  
Seminars in Hematology     Hybrid Journal   (Followers: 12)
Seminars in Thrombosis and Hemostasis     Hybrid Journal   (Followers: 45)
Thalassemia Reports     Open Access   (Followers: 1)
The Lancet Haematology     Full-text available via subscription   (Followers: 38)
Therapeutic Advances in Hematology     Hybrid Journal  
Thrombosis & Haemostasis     Hybrid Journal   (Followers: 145)
Thrombosis Research     Hybrid Journal   (Followers: 47)
Transfusionsmedizin - Immunhämatologie, Hämotherapie, Immungenetik, Zelltherapie     Hybrid Journal  
Transplantation and Cellular Therapy     Hybrid Journal   (Followers: 13)
Veins and Lymphatics     Open Access   (Followers: 1)

           

Similar Journals
Journal Cover
Journal of Hematopathology
Journal Prestige (SJR): 0.26
Number of Followers: 3  
 
  Hybrid Journal Hybrid journal (It can contain Open Access articles)
ISSN (Print) 1868-9256 - ISSN (Online) 1865-5785
Published by Springer-Verlag Homepage  [2469 journals]
  • Attack of the clones: a T-cell population resembling adult T-cell
           leukemia/lymphoma, and large granular lymphocytosis, in an HTLV-2-infected
           patient

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      Abstract: Abstract The HTLV-1 and HTLV-2 viruses, though closely genetically related, have divergent clinical impact: HTLV-1 has been causally linked with adult T-cell leukemia/lymphoma as well as neurologic disorders, whereas HTLV-2 shows no clear association with lymphoproliferative disorders. We report a patient who presented with two concomitant clonal T-cell lymphoproliferative disorders, who was found to have an HTLV-2, but not HTLV-1 infection. The patient’s clonal T-cell proliferations were characterized and compared using multiparameter flow cytometry, fluorescence in situ hybridization, and TCR gene rearrangement analysis on flow-sorted cell samples from blood, bone marrow, and skin biopsy specimens. The patient had a CD4 + /CD25 + T-cell population, resembling adult T-cell leukemia/lymphoma both by clinical presentation and immunophenotype, as well as a separate clonal CD8 + population of large granular lymphocytes. Interestingly, she also had a STAT3 mutation; large granular lymphocytic leukemia has been reported in association with HTLV-2 infection. This patient has had an indolent clinical course to date and is being managed expectantly. The unexpected finding of HTLV-2 infection is of uncertain significance with an unusual CD4 + /CD25 + clonal T-cell population resembling adult T-cell leukemia/lymphoma, but fits a reported association with clonal LGL-expansion and STAT3 mutation.
      PubDate: 2022-09-29
       
  • Hemoglobin Reims—a rare alpha globin chain variant and its
           interaction with beta thalassemia

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      Abstract: Abstract Non-sickle hemoglobin (Hb) variants that elute in HbS window in high performance liquid chromatography (HPLC) pose diagnostic challenges, especially in HbS prevalent geographies. We describe here two brothers (patients 1 and 2) with Hb Reims, a rare alpha globin chain variant that eluted in HbS window. Hb analysis was performed by HPLC. Covalent reverse dot blot and refractory mutation system (ARMS) were used for detection of common beta globin gene mutations. Alpha and beta globin gene mutation analysis was performed by DNA sequencing. Both brothers had “thalassemia trait-like” red cell indices. HbA2 was high (4.9%) in patient 2 and normal (2.7%) in patient 1. HbF was normal (0.3%) in both. The abnormal Hb peaks in patient 1 (21.7%) and patient 2 (13.8%) eluted at 4.51 and 4.48 min, respectively, in HPLC. Sickling test was negative in both. Gene sequencing confirmed heterozygous Hb Reims in both brothers resulting from an HBA1:c.71AC, GluGly; Codon 23 (GAG→GGG) mutation of alpha 1 globin gene. Both also had an alpha globin gene deletion (− α3.7/αα). Patient 2 additionally had heterozygous beta thalassemia resulting from Codon 15 (G→A) beta globin gene mutation. Hb Reims is a clinically silent Hb variant that needs to be distinguished from HbS. A co-existent beta thalassemia seems to have lowered the level of Hb Reims in patient 2. Only one case of Hb Reims has been reported earlier in the world literature and none from India where the two brothers hail from.
      PubDate: 2022-09-20
       
  • Clonal relationship of extranodal marginal zone lymphomas of
           mucosa-associated lymphoid tissue (MALT lymphoma) involving multiple organ
           systems with review of the literature

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      Abstract: Abstract Mucosa-associated lymphoid tissue (MALT) lymphomas are often multifocal with patchy distribution that can be scattered throughout an involved organ. Previous studies have shown that each of these surrounding foci is often clonally related. Less is known about the clonal relationship of MALT lymphomas that involve multiple different organ systems. To investigate the clonal relationship of MALT lymphomas that involve multiple different organ systems, we retrospectively reviewed records of all marginal zone lymphoma from our database. Three cases were found to have multiple organ involvement and subjected to the analysis of the rearranged immunoglobulin variable regions using a polymerase chain reaction–based assay. Three cases of MALT lymphomas arising from multiple sites include liver and lung, gastric and lung, nasopharynx, and parotid. Our results demonstrate that two of these cases show a clonal relationship; however, one case appears clonally distinct and appears unrelated. With reviewing the literature of MALT lymphomas that involve multiple different organ systems, it overall supports that clearly these have the potential to disseminate to other extranodal locations; however, involvement of multiple different organ systems should not necessarily be considered definitive evidence for disseminated or advanced disease.
      PubDate: 2022-09-20
       
  • Co-inheritance of Hb Ottawa and HbS: a rare interaction leading to an
           interesting diagnostic challenge

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      PubDate: 2022-09-14
       
  • The first case of peripheral T cell lyphoma with a CSF3R variant resulted
           in relapsing febrile neutropenia and aplastic anemia

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      Abstract: Abstract Colony-stimulating factor 3 receptor (CSF3R) gene mutations have been previously identified in chronic neutrophilic leukemia, atypical chronic myeloid leukemia, chronic myelomonocytic leukemia, de novo acute myeloid leukemia, and severe congenital neutropenia, although there is limited data regarding lymphoid malignancies. Here, we present the first case of peripheral T cell lymphoma with CSF3R variant that developed persistent neutropenia in the follow-up visit and aplastic anemia after autologous hematopoietic stem cell transplantation. Next-generation sequencing (NGS) was performed on bone marrow aspiration (Qiagen clinical insight-QCI™). CSF3R single nucleotide variant (transcript variant 4), 46.0% (of 1081 reads) of variant allele fraction on exon 16 (lying to intronic region), nucleotide NM_172313.3, g36932463A > g, c.2041-35 T > C was identified by NGS. The case study presented here is an example of use of NGS in diagnosis, classification, prognostic or response indicator of hematologic malignancies, and identification of targeted therapy options in clinical practice. Additional work is needed to understand the clinical significance of this mutation.
      PubDate: 2022-09-06
       
  • Blister cells in sickle cell anemia

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      PubDate: 2022-09-01
       
  • Kikuchi–Fujimoto disease in a child who had a high suspicion of
           COVID-19 infection

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      PubDate: 2022-09-01
       
  • Reversible follicular lymphoid hyperplasia related with dasatinib: first
           case report from Turkey

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      Abstract: Abstract Chronic myeloid leukemia (CML) is a clonal hematopoietic stem cell disorder characterized by the presence of a cytogenetic abnormality, the Philadelphia (Ph) chromosome. BCR-ABL tyrosine kinase inhibitors (TKIs) have revolutionized the treatment of chronic myeloid leukemia (CML). Patients who respond to treatment achieve a near-normal life expectancy. In this case report, we present the first case from Turkey of reversible follicular lymphoid hyperplasia (FLH) related to the use of a second-generation TKI, dasatinib. A peripheral blood specimen was evaluated by double-fusion fluorescence in situ hybridization (FISH) for cytogenetics and by quantitative RT–PCR (qPCR) for BCR-ABL1 mRNA transcripts. The cervical lymph node biopsy tissue was embedded in paraffin and sectioned following routine methods after fixation in neutral buffered formalin. Immunohistochemical staining was applied for further evaluation. A 64-year-old male CML patient with complete cytogenetic response (CCyR) and major molecular response (MMR) presented with lymphadenopathies accompanied by mild lymphocytosis following 3 months of dasatinib treatment. The patient was diagnosed with FLH. After termination of dasatinib, the lymphadenopathies regressed during follow-up. FLH should be considered a rare side effect of dasatinib. A watch and wait strategy following dasatinib treatment termination would be suitable.
      PubDate: 2022-09-01
       
  • High expression of OX-40, ICOS, and low expression PD-L1 of follicular
           helper and follicular cytotoxic T cells in chronic lymphocytic leukemia

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      Abstract: Abstract Chronic lymphocytic leukemia (CLL) is the most common leukemia in the elderly. T follicular helper (TFH) and follicular cytotoxic T (TFC) cells are a subset of CD4+ and CD8+ T cells expressing CXCR5, respectively. OX-40, ICOS, and PD-L1 are secondary immune checkpoint molecules and have a role in the maintenance of an immune response. The literature about the role of ICOS, OX-40, and PD-L1 receptors of TFH and, especially TFC cells, in CLL is limited. In this study, peripheral blood mononuclear cells (PBMCs) were isolated from heparinized blood samples by density gradient centrifugation using Ficoll-Paque from 34 CLL patients and 19 healthy subjects. The expression of ICOS, OX-40, and PD-L1 of TFC and TFH cells in CLL patients was investigated by flow cytometry. According to healthy subjects, TFH and TFC cell levels were increased in CLL patients. High-ICOS and low-PD-L1 expression in TFH cells and high OX-40 and ICOS, low-PD-L1 expression in TFC cells of CLL patients compared to healthy subjects. OX-40 expression was positively correlated with TFH and TFC cells levels [R = 0.504, (p = 0.002) and R = 0.316, (p = 0.05)]. Additionally, OX-40 expression of TFH was positively correlated with ICOS expression [R = 0.660, (p < 0.001)] and PD-L1 expression [R = 0.649, (p < 0.001)]. OX-40L, ICOSL, and PD-L1 expression of B cells were elevated in CLL patients compared to healthy subjects. OX-40L expression of B cells was positively correlated with ICOSL expression [R = 0.568, (p = 0.0004)] and PD-L1 expression. Elevated CD4+CXCR5+ TFH and CD8+CXCR5+ TFC cells with high OX-40 and ICOS activator and low-PD-1L inhibitor receptor expression in CLL patients might have a role in the pathogenesis of CLL.
      PubDate: 2022-09-01
       
  • Competing hematolymphoid classification schemes on deck

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      PubDate: 2022-08-30
       
  • Nodular lymphocyte-predominant Hodgkin lymphoma and clinical impact of its
           variant histology: a clinicopathologic study from tertiary cancer centre
           in India

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      Abstract: Abstract Nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) can show variant histological patterns, some of which may be associated with an advanced stage and increased relapse rate. Through this study, we put the various histological patterns of NLPHL under spotlight and assess their prognostic implications. A retrospective histologic and immunohistochemistry review of all archival slides of NLPHL over a period of 6 years was performed. A total of 36 cases were identified. We recognised the typical (A, B) and histopathologic variant patterns (C to F) of NLPHL as per the criteria given by Fan et al. and scored these cases using the 5 histological parameters described by Shet et al. Complete clinical follow-up information could be obtained in 25 cases. Patients with NLPHL constituted 6.4% of Hodgkin lymphoma cases in our institute. While predominant typical histological patterns were seen in 9/36 patients, variant patterns C, D, E, and F were observed in 15, 3, 7, and 2 cases respectively. All cases with typical growth patterns showed a score of ≤ 5 and those with variant histologies showed scores between 2 and 9. Relapse of lymphoma was seen in 7 cases, all of which showed a variant histology. The histopathological scores increased or stayed constant at the time of relapse. Histopathological growth patterns at the time of initial diagnosis and disease relapse were consistent in 6/7 cases. Transformation to large B-cell lymphoma was seen in 1 case. We could conclude that NLPHL cases with variant histology showed an increased risk of relapse. The histopathological growth patterns remained consistent in majority cases at relapse.
      PubDate: 2022-08-23
       
  • The risk and prognostic influence of caspase 9 promotor polymorphisms in
           Egyptian patients with acute myeloid leukemia

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      Abstract: Abstract Acute myeloid leukemia (AML) is a genetic disorder of hematopoietic stem cells (HSCs) followed by clonal selection and uncontrolled proliferation leading to malignant neoplasm. Inappropriate regulation of apoptosis contributes to many human disorders including cancer. Caspase 9 (CASP9) is associated with the intrinsic pathway of apoptosis. Functional single-nucleotide polymorphisms (SNPs) in CASP9 might influence gene expression leading to altered apoptosis and increased AML risk. Previously, two CASP9 promoter polymorphisms (CASP9 1263 rs4645978A > G and CASP9 712 rs4645981C > T) were shown to be associated with increased risk of developing AML and inferior AML survival in South Indian subjects. This study was to evaluate these polymorphisms in an independent cohort of AML patients and controls in Egypt. PCR–RFLP for CASP9 1263 rs4645978 A > G and CASP9 712 rs4645981 C > T genotypes were done in 60 de novo AML cases and 40 healthy control subjects. Our study showed that CASP9 712 rs4645981 C > T gene polymorphism is associated with increased risk of developing AML and poor disease outcome (p value = 0.006, < 0.001; OR = 3.644, 26; and 95% CI = 1.39–9.528, 6.5–103.5, respectively). In contrast, CASP9 1263 rs4645978 A > G showed no significant difference between AML patients and the controls regarding the risk of developing AML or disease outcome (p value = 0.301, 0.573, respectively). CASP9 712 rs4645981 C > T could be involved in the pathophysiology and development of AML in Egypt and may be useful as a predictive molecular markers for inferior prognosis in AML. Notably, risk was highest and outcomes worst in patients with both the 712C > T and 1263A > G alleles.
      PubDate: 2022-08-06
       
  • De novo acute myeloid leukemia harboring concomitant
           t(8;21)(q22;q22);RUNX1::RUNX1T1 and BCR::ABL1 (p190 minor transcript)

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      Abstract: Abstract De novo AMLs with typical nonrandom chromosomal abnormalities are often associated with specific morphology subtypes. The t(8;21) is one of the most prominent recurrent cytogenetic aberrations (RCA) in AML, frequently associated with AML with maturation, and is characterized as a good prognostic marker. On the contrary, BCR::ABL1 rearrangement is rarely observed in AMLs, without specific morphology, carrying poor prognosis. Its distinction from blastic transformation of chronic myeloid leukemia has been a matter of long debate. The revised WHO classification (2016) recognized AML with BCR::ABL1+ as a provisional entity. The occurrence of additional cytogenetic aberrations in AML RCA within the same leukemic clone has been detected, albeit rare cases of BCR::ABL1+ were reported, mainly as subclones. Those additional cytogenetic and molecular findings seem to significantly affect patient prognosis. Conventional cytogenetic analysis, fluorescent in situ hybridization (FISH), and polymerase chain reaction (PCR) were applied at presentation and during the follow-up of the patient. We present a 34-year-old male patient with de novo AML harboring concomitant t(8;21) and t(9;22) in a single clone. The presence of both t(8;21) and Philadelphia chromosome (Ph+) in the same metaphases but in less than 100% of the analyzed cells, the p190 BCR::ABL transcript type, and absence of splenomegaly support that additional BCR::ABL1+ is a part of the main leukemic clone. These findings, accompanied with an encouraging outcome of continuous cytogenetic and molecular remission after induction therapy, support BCR::ABL1 being a secondary genetic event in AML with t(8;21).
      PubDate: 2022-07-31
       
  • EBV-positive follicular lymphoma and concurrent EBV-negative diffuse large
           B-cell lymphoma illustrating branched evolution model and “Hit and
           Run” hypothesis

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      Abstract: Abstract Epstein-Barr virus (EBV) is one of the most common viruses associated with multiple malignancies including hematopoietic, epithelial, and mesenchymal neoplasms. EBV is linked to B- and T-cell lymphomas, ranging from indolent to highly aggressive neoplasms. EBV-positive follicular lymphoma (FL) is not well characterized due to its low prevalence. In this report, we describe a case of EBV-positive FL and concurrent EBV-negative diffuse large B-cell lymphoma (DLBCL), and discuss their clonal relationship, and EBV status in the process of disease progression. Histology, immunohistochemistry, in situ hybridization, and next-generation sequencing studies were performed as previously described. The 58-year-old male presented with extensive axillary and subpectoral lymphadenopathy. The patient had a history of mixed connective tissue disease treated in the past with steroids and methotrexate, and at the time of current presentation with hydroxychloroquine. The excision of axillary lymph node showed coexistent EBV-positive FL (grade 3B) and EBV-negative DLBCL. There was no evidence of BCL2 gene rearrangement; however, both EBV-positive neoplastic follicles and diffuse component harbored MYC/IGH rearrangement. Next-generation sequencing suggested branching evolution with shared DDX3X mutation, a number of private mutations, and unique IGH usage in FL and DLBCL. The patient was treated with six cycles of R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisolone) with involved-field radiotherapy and remains in complete remission. To the best of our knowledge, this is the first report of BCL2 rearrangement negative, MYC/IGH-positive and EBV-positive FL, and concurrent EBV-negative DLBCL, which supports branched evolution model.
      PubDate: 2022-07-28
      DOI: 10.1007/s12308-022-00502-x
       
  • Marrow cryptococcosis in an autologous stem cell transplant patient after
           standard therapy for cryptococcal meningitis

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      Abstract: Abstract The patient is a woman in her 60s with a history of plasma cell myeloma, status post high-dose melphalan and autologous stem cell transplant, followed by maintenance lenalidomide. She was admitted for severe headaches with concern for meningitis. CSF culture yielded Cryptococcus neoformans. Cryptococcal antigen was present at high titer in the CSF (1:640) but was negative in serum. A diagnosis of cryptococcal meningitis was rendered. She was treated with over 2 weeks of intravenous amphotericin plus flucytosine. Upon discharge, her CSF cryptococcal antigen test remained positive (1:2560) but CSF culture was negative. She continued to experience mild headaches after discharge and was maintained on daily oral fluconazole. Several months later, a bone marrow biopsy was performed to evaluate for residual myeloma post-transplant. There was no morphologic, immunohistochemical, or flow cytometric evidence of residual plasma cell neoplasm. However, the core biopsy revealed suspicious clusters of histiocytes (A) with numerous cytoplasmic inclusions, some of which appeared to contain thick cell wall-like structures (B). Special stains, including periodic acid-Schiff (PAS, C) and Grocott’s methenamine silver (GMS, D), identified variably sized yeast forms, morphologically compatible with Cryptococcus. Infected histiocytes were not visualized on the aspirate smears. A repeat serum cryptococcal antigen test was positive (1:640). She was kept on daily oral fluconazole and is being closely followed by infectious disease. Immunocompromised patients are at increased risk for a variety of marrow infections, including Cryptococcus. Patients with plasma cell myeloma are at risk for invasive fungal infections after autologous stem cell transplant and while taking lenalidomide, which alters CD4 + and CD8 + T-cell function through multiple mechanisms. Due to a lack of standardized treatment protocols for therapy-refractory non-pulmonary non-meningeal cryptococcal disease, therapy regimens are often tailored on a case-by-case basis.
      PubDate: 2022-07-21
      DOI: 10.1007/s12308-022-00507-6
       
  • Extramedullary hematopoiesis in β-thalassemia major patient: a case
           report and review of the literature

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      Abstract: Abstract Extramedullary hematopoiesis (EMH), as a compensatory phenomenon, refers to the blood cell formation outside of the bone marrow that occurs once the cells in the circulatory system fail to meet individuals’ needs. EMH is rare in moderate to severe beta thalassemia because most symptomatic patients are effectively managed with transfusion. However, patients that fail to receive transfusions like β-thalassemia intermedia (β-TI) as indicated are at increased risk for developing EMH. This paper describes the case of a 15-year-old female adolescent with β-thalassemia major (β-TM), suffering from a rare form of EMH affecting the sinus cavities, characterized by headache, sinusitis, and nasal obstruction, as confirmed by physical-pathological examinations and computerized tomography (CT) scan findings. The EMH in this patient could be significantly attributed to the lack of regular blood transfusions in recent years. It was concluded that β-TM along with the occurrence of EMH in the sinus cavities had led to a complex case, carrying a heavy burden of the disease for the patient.
      PubDate: 2022-07-15
      DOI: 10.1007/s12308-022-00506-7
       
  • Familial hemophagocytic lymphohistiocytosis with Epstein–Barr virus
           infection and progression to aggressive NK-cell leukemia: a case report
           and review of the literature

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      Abstract: Abstract Familial hemophagocytic lymphohistiocytosis (FHLH) with Epstein–Barr virus (EBV) infection can mimic chronic active EBV infection of T- and NK-cell type (CAEBV-T/NK) in its clinical manifestation and pathomorphology. FHLH with genetic susceptibility to EBV has not been previously reported. The development of FHLH in conjunction with EBV infection is rare and needs further investigation to understand and characterize it. We report a rare case of FHLH with EBV infection that mimicked CAEBV-T/NK, but progressed to childhood aggressive natural killer cell leukemia (ANKL). The patient is in clinical remission following allogeneic hematopoietic stem cell transplantation (allo-HSCT). Our reported case suggests that patients with FHLH and EBV infection, especially those with symptoms similar to those of CAEBV-T/NK, may rapidly progress to ANKL or other neoplastic diseases. Therefore, we must be aware of these cases to ensure that patients are diagnosed correctly so they can be treated appropriately and in a timely manner.
      PubDate: 2022-07-14
      DOI: 10.1007/s12308-022-00503-w
       
  • Mediastinal B-cell lymphoma with MYC, BCL2, and BCL6 rearrangements

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      Abstract: Abstract Primary mediastinal B-cell lymphoma (PMBL) is a rare but aggressive form of non-Hodgkin lymphoma (NHL) that shares significant overlap with Diffuse large B-cell lymphoma (DLBCL). Double- (DH) and triple-hit (TH) lymphomas are aggressive B-cell lymphomas with translocations involving MYC + BCL2 or BCL6 and MYC + BCL2 + BCL6, respectively. There are only 2 previous reports of DH in PMBL and no reports of TH. Here, we present the case of a 23-year-old female with post-treatment relapse of PMBL into a PMBL-TH, after initially presenting with MYC but without either BCL2 or BCL6 rearrangement. Immunohistochemistry (IHC), fluorescence in situ hybridization (FISH), and the Lymph3Cx gene expression assay were used to confirm the diagnosis. This case initiates the literature for PMBL-TH and expands the overall knowledge base regarding DH/TH in B-cell lymphomas. It also further emphasizes the utility of genetic and molecular assays in clinical identification of unique B-cell lymphoma subtypes when considering potential treatment courses.
      PubDate: 2022-07-14
      DOI: 10.1007/s12308-022-00505-8
       
  • An atypical plasmablastic proliferation — should we suspect
           vedolizumab'

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      Abstract: Abstract We chronicle a case of an atypical plasmablastic proliferation in a patient occurring in the context of vedolizumab, a novel therapy for the treatment of inflammatory bowel disease (IBD). No documented cases exist of this potential association, and we propose a pathogenic mechanism. A 22-year-old female with IBD had a flare of colitis and required a subtotal colectomy. She had been on vedolizumab for 2 years. Histology revealed indeterminate colitis but discovered a densely cellular polypoid lesion of plasmablasts and plasma cells of varying maturation, positive for MUM1, BLIMP1, c-myc, IgG, and CD138, with a lambda light chain restriction, but negative for CD20 and PAX5. The combined diagnosis was of an atypical plasmablastic proliferation that mimicked a plasmablastic lymphoma; however, this diagnosis was confounded by its atypical presentation: a young female on vedolizumab, and we queried what pathogenic role vedolizumab may have had. Vedolizumab selectively targets α4β7 integrin, a leucocyte adhesion molecule, to inhibit gut lymphocyte accretion and reduce inflammation. A similar phenomenon occurs with HIV-infection. HIV-gp120 binding with α4β7 leads to a loss of gut CD4 + lymphocytes and the potential to develop plasmablastic lymphoma, an AIDS-defining diagnosis. Concurrent use of vedolizumab at diagnosis suggests a synergistic causal effect given the molecular mimicry of its target α4β7 seen also with HIV-infection. This is the first documented case of a plasmablastic proliferation, or of any clonal cellular proliferation, to occur in the context of vedolizumab. α4β7 integrin antagonism may carry oncogenic sequelae, and we recommend further investigation to understand its pathogenesis.
      PubDate: 2022-07-13
      DOI: 10.1007/s12308-022-00504-9
       
  • Correction to: What, how, and when for the WHO: will the clock be turned
           back for the next hematolymphoid tumor classification'

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      PubDate: 2022-05-27
      DOI: 10.1007/s12308-022-00500-z
       
 
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