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Advances in Hematology
Journal Prestige (SJR): 0.661

Citation Impact (citeScore): 2
Number of Followers: 13

This is an Open Access Journal

Open Access journal
ISSN (Print) 1687-9104 - ISSN (Online) 1687-9112
Published by Hindawi

[340 journals]

Evaluation of Bacterial Contamination in Donated Blood for Transfusion
Purposes at Kisii Teaching and Referral Hospital
- Abstract: Conclusion: S. epidermidis, S. aureus, Bacillus spp. and E. coli were among the isolated and identified bacteria found in donated blood samples among donors at KTRH.
  PubDate: Sat, 28 Jun 2025 02:04:41 +000
Reduction of Blood Transfusion in Iron Deficiency Anemia (ReBIDA): A
Quality Improvement Initiative
- Abstract: Discussion: This work demonstrates how multidisciplinary, education- and evidence-based interventions lead to clinically and statistically significant reductions in PRBC transfusion for admitted patients with IDA.
  PubDate: Tue, 17 Jun 2025 01:27:41 +000
Dysregulation of Ceruloplasmin, α2-Macroglobulin, and
Alpha-2-HS-Glycoprotein in Transfusion-Dependent Thalassemia
- Abstract: Transfusion-dependent thalassemia (TDT) is a severe inherited anemia characterized by impaired synthesis of hemoglobin chains. Disease progression and TDT severity are potentially linked to oxidative stress and protein damage. This study aimed to explore the expression patterns of ceruloplasmin (CP), α2-macroglobulin (A2M), and alpha-2-HS-glycoprotein (AHSG) in TDT serum through quantitative proteomic profiling. The results were validated using enzyme-linked immunosorbent assays (ELISA). The study participants were divided into three groups based on the duration of blood transfusion. Age and gender-matched normal individuals served as controls. The results revealed the downregulation of these proteins. The reduced levels of these proteins may contribute to tissue damage in TDT patients, primarily due to increased oxidative stress. For example, decreased CP levels can disrupt iron and copper metabolism, leading to heightened oxidative stress and rendering red blood cell membranes more susceptible to rupture due to active oxygen radicals. In summary, CP, A2M, and AHSG association with iron metabolism, inflammation, and oxidative stress underscores their potential relevance in understanding TDT’s pathogenesis and progression. These findings may pave the way for improved diagnostic and therapeutic strategies for TDT patients.
  PubDate: Mon, 19 May 2025 04:20:10 +000
Deferrals for Low Haemoglobin and Anaemia Among First-Time Prospective
Blood Donors in Southern Ghana: Results From the BLOODSAFE Ghana—Iron
and Nutritional Counselling Strategy Pilot (BLIS) Study
- Abstract: Trial Registration: ClinicalTrials.gov identifier: NCT04949165
  PubDate: Tue, 06 May 2025 21:04:48 +000
Role of Extended White Blood Cell Parameters in Distinguishing Acute
Febrile Illnesses
- Abstract: Conclusion: HFLC was a useful diagnostic tool to identify viral infection, particularly dengue infection, while IG, NLR, NE-SFL, and NE-WY can be useful to differentiate bacteremia from other acute febrile illnesses.
  PubDate: Mon, 21 Apr 2025 03:34:16 +000
Assessment of Unexpected (Non-ABO) Red Blood Cell Antibodies and Their
Associated Clinical Conditions Among Patients and Blood Donors Attending
University Teaching Hospital of Kigali (CHUK) and Rwanda Blood Transfusion
Division
- Abstract: Unexpected antibodies can cause hemolytic conditions. Therefore, screening for unexpected antibodies is essential for safe transfusion. The study was conducted at Rwanda Blood Transfusion Division and University Teaching Hospital of Kigali to assess unexpected antibodies with their associated clinical conditions. 8693 blood donors and 834 patients were screened for unexpected antibodies. Among 834 patients, 23 patients (2.75%) developed alloantibodies among which two of them had mixed alloantibodies. Five patients developed antibodies of uncertain specificities. Among 8693 blood donors, only 4 blood donors (0.046%) had clinically significant alloantibodies, whereas 6 blood donors (0.069%) had antibodies of uncertain specificities. Moreover, 3 patients (0.35%) had autoantibodies in their plasma. Different types of anemia were presented with patients who developed unexpected alloantibodies. History of transfusion and pregnancy were predictors of alloimmunization among patients (). Antibody screening and antibody identification are important for safe blood transfusion practices.
  PubDate: Wed, 19 Mar 2025 04:18:17 +000
AL Amyloidosis: Current Treatment and Outcomes
- Abstract: Trial Registration: ClinicalTrials.gov identifier: NCT04270175, NCT05451771, NCT04847453, and NCT05199337
  PubDate: Mon, 03 Mar 2025 09:15:27 +000

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