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HEMATOLOGY (160 journals)                     

Showing 1 - 122 of 122 Journals sorted alphabetically
Acta Angiologica     Open Access   (Followers: 3)
Adipocyte     Open Access  
Advances in Hematology     Open Access   (Followers: 13)
Africa Sanguine     Full-text available via subscription  
American Journal of Hematology     Hybrid Journal   (Followers: 46)
Anemia     Open Access   (Followers: 6)
Annals of Hematology     Hybrid Journal   (Followers: 14)
Arteriosclerosis, Thrombosis and Vascular Biology     Full-text available via subscription   (Followers: 25)
Artery Research     Hybrid Journal   (Followers: 4)
Artificial Cells, Nanomedicine and Biotechnology     Hybrid Journal   (Followers: 3)
ASAIO Journal     Hybrid Journal   (Followers: 2)
Best Practice & Research Clinical Haematology     Hybrid Journal   (Followers: 5)
Blood     Hybrid Journal   (Followers: 296)
Blood Advances     Open Access   (Followers: 9)
Blood and Lymphatic Cancer : Targets and Therapy     Open Access   (Followers: 7)
Blood Cancer Journal     Open Access   (Followers: 21)
Blood Cells, Molecules, and Diseases     Hybrid Journal   (Followers: 5)
Blood Coagulation & Fibrinolysis     Hybrid Journal   (Followers: 27)
Blood Pressure     Open Access   (Followers: 1)
Blood Pressure Monitoring     Hybrid Journal   (Followers: 2)
Blood Reviews     Hybrid Journal   (Followers: 20)
BMJ Open Diabetes Research & Care     Open Access   (Followers: 23)
Bone Marrow Transplantation     Hybrid Journal   (Followers: 15)
British Journal of Haematology     Hybrid Journal   (Followers: 54)
Canadian Journal of Diabetes     Hybrid Journal   (Followers: 9)
Case Reports in Hematology     Open Access   (Followers: 10)
Clinical and Applied Thrombosis/Hemostasis     Open Access   (Followers: 28)
Clinical Diabetes     Full-text available via subscription   (Followers: 30)
Clinical Diabetes and Endocrinology     Open Access   (Followers: 14)
Clinical Lymphoma & Myeloma     Full-text available via subscription   (Followers: 2)
Conquest : The Official Journal of Diabetes Australia     Full-text available via subscription   (Followers: 1)
Current Angiogenesis     Hybrid Journal   (Followers: 1)
Current Diabetes Reports     Hybrid Journal   (Followers: 14)
Current Diabetes Reviews     Hybrid Journal   (Followers: 13)
Current Hematologic Malignancy Reports     Hybrid Journal   (Followers: 2)
Current Opinion in Hematology     Hybrid Journal   (Followers: 14)
Cytotherapy     Full-text available via subscription   (Followers: 1)
Der Diabetologe     Hybrid Journal  
Diabetes     Full-text available via subscription   (Followers: 262)
Diabetes aktuell     Hybrid Journal   (Followers: 2)
Diabetes and Vascular Disease Research     Hybrid Journal   (Followers: 8)
Diabetes Care     Full-text available via subscription   (Followers: 285)
Diabetes Case Reports     Open Access  
Diabetes Educator     Hybrid Journal   (Followers: 10)
Diabetes Research and Clinical Practice     Hybrid Journal   (Followers: 18)
Diabetes Spectrum     Full-text available via subscription   (Followers: 14)
Diabetes Technology & Therapeutics     Hybrid Journal   (Followers: 8)
Diabetes Therapy     Open Access   (Followers: 13)
Diabetic Foot & Ankle     Open Access   (Followers: 9)
Diabetic Medicine     Hybrid Journal   (Followers: 93)
Diabetologia     Hybrid Journal   (Followers: 107)
Diabetologie und Stoffwechsel     Hybrid Journal  
Egyptian Journal of Hematology and Bone Marrow Transplantation     Open Access   (Followers: 9)
eJHaem     Open Access   (Followers: 1)
European Journal of Haematology     Hybrid Journal   (Followers: 12)
Experimental Hematology     Hybrid Journal   (Followers: 3)
Experimental Hematology & Oncology     Open Access   (Followers: 6)
Expert Review of Hematology     Hybrid Journal   (Followers: 4)
Fluids and Barriers of the CNS     Open Access   (Followers: 1)
Haematologica - the Hematology journal     Open Access   (Followers: 35)
Haemophilia     Hybrid Journal   (Followers: 15)
Hematologia     Full-text available via subscription   (Followers: 3)
Hematology     Open Access   (Followers: 9)
Hematology, Transfusion and Cell Therapy     Open Access   (Followers: 2)
Hemodialysis International     Hybrid Journal   (Followers: 3)
Hepatitis Monthly     Open Access   (Followers: 3)
Immunohematology : Journal of Blood Group Serology and Molecular Genetics     Hybrid Journal   (Followers: 3)
Indian Journal of Hematology and Blood Transfusion     Hybrid Journal   (Followers: 1)
Info Diabetologie     Full-text available via subscription  
InFo Hämatologie + Onkologie : Interdisziplinäre Fortbildung von Ärzten für Ärzte     Full-text available via subscription  
Integrated Blood Pressure Control     Open Access   (Followers: 1)
International Blood Research & Reviews     Open Access  
International Journal of Clinical Transfusion Medicine     Open Access   (Followers: 3)
International Journal of Diabetes in Developing Countries     Hybrid Journal   (Followers: 5)
International Journal of Diabetes Research     Open Access   (Followers: 6)
International Journal of Hematology     Hybrid Journal   (Followers: 3)
International Journal of Hematology Research     Open Access   (Followers: 2)
International Journal of Laboratory Hematology     Hybrid Journal   (Followers: 24)
JMIR Diabetes     Open Access  
Journal of Blood Medicine     Open Access  
Journal of Cerebral Blood Flow & Metabolism     Hybrid Journal   (Followers: 3)
Journal of Diabetes     Open Access   (Followers: 12)
Journal of Diabetes and its Complications     Hybrid Journal   (Followers: 13)
Journal of Diabetes and Metabolic Disorders     Open Access   (Followers: 6)
Journal of Diabetes Investigation     Open Access   (Followers: 6)
Journal of Diabetes Mellitus     Open Access   (Followers: 4)
Journal of Hematological Malignancies     Open Access  
Journal of Hematology and Transfusion Medicine     Open Access   (Followers: 1)
Journal of Hematopathology     Hybrid Journal   (Followers: 3)
Journal of Pediatric Hematology/Oncology     Hybrid Journal   (Followers: 6)
Journal of Social Health and Diabetes     Open Access  
Journal of Thrombosis and Haemostasis     Hybrid Journal   (Followers: 52)
Journal of Thrombosis and Thrombolysis     Hybrid Journal   (Followers: 30)
Leukemia     Hybrid Journal   (Followers: 23)
Leukemia and Lymphoma     Hybrid Journal   (Followers: 13)
Leukemia Research     Hybrid Journal   (Followers: 9)
Leukemia Research Reports     Open Access   (Followers: 1)
Leukemia Supplements     Full-text available via subscription  
Nederlands Tijdschrift voor Diabetologie     Hybrid Journal  
Nutrition & Diabetes     Open Access   (Followers: 18)
Oncohematology     Open Access   (Followers: 1)
Open Diabetes Journal     Open Access  
Open Hematology Journal     Open Access   (Followers: 1)
Open Hypertension Journal     Open Access  
Open Journal of Blood Diseases     Open Access  
Pediatric Blood & Cancer     Hybrid Journal   (Followers: 6)
Pediatric Hematology Oncology Journal     Open Access   (Followers: 3)
Peritoneal Dialysis International     Hybrid Journal  
Plasmatology     Open Access   (Followers: 1)
Platelets     Hybrid Journal   (Followers: 2)
Practical Diabetes     Hybrid Journal   (Followers: 4)
Primary Care Diabetes     Hybrid Journal   (Followers: 16)
Research and Practice in Thrombosis and Haemostasis     Open Access   (Followers: 2)
Revista Cubana de Hematología, Inmunología y Hemoterapia     Open Access  
Seminars in Hematology     Hybrid Journal   (Followers: 9)
Seminars in Thrombosis and Hemostasis     Hybrid Journal   (Followers: 28)
The Lancet Haematology     Full-text available via subscription   (Followers: 43)
Therapeutic Advances in Hematology     Hybrid Journal  
Thrombosis & Haemostasis     Hybrid Journal   (Followers: 105)
Thrombosis Research     Hybrid Journal   (Followers: 30)
Transplantation and Cellular Therapy     Hybrid Journal   (Followers: 11)
Veins and Lymphatics     Open Access   (Followers: 1)

           

Similar Journals
Journal Cover
Revista Cubana de Hematología, Inmunología y Hemoterapia
Journal Prestige (SJR): 0.196
Number of Followers: 0  

  This is an Open Access Journal Open Access journal
ISSN (Print) 0864-0289 - ISSN (Online) 1561-2996
Published by SciELO Homepage  [688 journals]
  • Modelo predictivo de crisis vasoclusiva en la anemia drepanocítica

    • Abstract: RESUMEN Introducción: El diagnóstico precoz de la crisis vasoclusiva (CVO) que afecta a pacientes con drepanocitosis resulta un tema no resuelto en la actualidad. No se ha encontrado en la literatura evidencia de modelos que puedan establecer tempranamente índices de riesgo de la CVO para la toma de una conducta terapéutica oportuna en estos pacientes. Objetivo: Establecer índices de riesgo en pacientes con drepanocitosis, a partir de la formulación de un modelo predictivo del estado vasoclusivo. Métodos: A partir de un estudio analí tico transversal de casos y controles, realizado en el Centro Hematológico de Santiago de Cuba, se formuló a través de un análisis discriminante, un modelo predictivo del estado de CVO. Se usaron estadígrafos de dispersión (media y desviación estándar) para el establecimiento de índices de riesgo sustentados en él. Resultados: Se formuló un modelo predictivo del estado de CVO que incluyó biomarcadores del estado redox como predictores significativos en el paciente con drepanocitosis. El modelo sustentó los índices de riesgo, estratificados en 3 categorías (riesgo menor, moderado y mayor) que fueron asignados a los pacientes y posibilitó su adecuada clasificación. Conclusiones: El diseño de un modelo predictivo de CVO y el establecimiento de índices de riesgo en pacientes con drepanocitosis permitió una mejor evaluación. La nueva herramienta diagnóstica que se propone resultaría de gran utilidad en los servicios de Hematología, al facilitar una mejor valoración del estado del paciente con drepanocitosis y un tratamiento profiláctico oportuno que minimice las complicaciones asociadas a este estado.ABSTRACT Introduction: The early diagnosis of vasooclusive crisis affecting sickle cell patients is currently an unresolved issue. In the reviewed literature no models have been found able to establish early risk indices of vasooclusive crisis for taking a timely therapeutic behavior in these patients. Objective: To establish risk indices in sickle cell patients based on the formulation of a predictive model of vasoocclusive state. Methods: Based on a cross-sectional case-control analytic study conducted at the Hematological Center of Santiago de Cuba, a predictive model of VOC status was formulated through a discriminant analysis. Dispersion statistics (mean and standard deviation) were used to establish risk indices based on it. Results: A predictive model of the state of VOC that included biomarkers of the redox state as significant predictors of it in sickle cell patients was formulated. The model supported the risk indices, stratified into 3 categories (lower, moderate and higher risk) that were assigned to the patients and allowed an adequate classification of them. Conclusions: The design of a predictive model of VOC and the establishment of risk indices in sickle cell patients allowed a better evaluation of them. The new diagnostic tool proposed in the study would be very useful in the Hematology services, by facilitating a better assessment of the sickle cell patient's condition and a timely prophylactic treatment that minimizes the complications associated with this state.
       
  • CARL y MPL en pacientes cubanos con trombocitemia esencial y mielofibrosis
           primaria

    • Abstract: RESUMEN Introducción: La trombocitemia esencial y la mielofibrosis primaria comparten la presencia de las mutaciones JAK2, CALR y MPL. En total, están presentes en poco más del 90 % de los pacientes con estas enfermedades. Objetivos: Determinar el comportamiento de las mutaciones más frecuentes en los genes MPL y CALR en pacientes cubanos. Métodos: Se realizó un estudio ambispectivo, descriptivo y longitudinal en el Instituto de Hematología e Inmunología de Cuba, entre los años 2010 y 2020. Se incluyeron todos los pacientes con sospecha de trombocitemia esencial y de mielofibrosis primaria con muestras de ADN válidas. Se les identificaron las mutaciones CALR y MPL por PCR en tiempo real. Resultados: De los 53 pacientes estudiados, el 67,9 % fueron diagnosticados con trombocitemia esencial, el 22,6 % con mielofibrosis primaria. En el 90,6 % se pudo detectar alguna de las mutaciones conductoras; el 67,9 % fueron positivos a la mutación JAK2V617F, el 13,2 % a las mutaciones en el gen que codifica para la calreticulina y en el 9,4 % se identificaron mutaciones en el gen MPL. Conclusiones: El comportamiento de las mutaciones conductoras JAK2V617F, CALR y MPL en la muestra de pacientes cubanos con trombocitemia esencial y mielofibrosis primaria estuvo en correspondencia con lo descrito en la mayoría de las investigaciones.ABSTRACT Introduction: Essential thrombocythemia and primary myelofibrosis share the presence of JAK2, CALR and MPL mutations. In total, they comprise slightly more than 90 % of patients with these diseases. Objectives: To determine the behavior of the most frequent mutations in MPL and CALR genes in Cuban patients. Methods: An ambispective, descriptive and longitudinal study was performed at the Institute of Hematology and Immunology of Cuba, between 2010 and 2020. All patients with suspected essential thrombocythemia and primary myelofibrosis with valid DNA samples were included. CALR and MPL mutations were identified by real-time PCR. Results: Of the 53 patients studied, 67.9% were diagnosed with essential thrombocythemia, and 22.6% with primary myelofibrosis. In 90.6% it was possible to detect any of the driver mutations: 67.9% were positive for the JAK2V617F mutation, 13.2% for mutations in the gene coding for calreticulin and in 9.4% mutations in the MPL gene were identified. Conclusions: The behavior of the driver mutations JAK2V617F, CALR and MPL in the sample of Cuban patients with essential thrombocythemia and primary myelofibrosis was in correspondence with what is described in the majority of the investigations.
       
  • Efectos de la lecitina de soya en parámetros hematológicos y marcadores
           inflamatorios sistémicos de ratas

    • Abstract: RESUMEN Introducción: El estudio de los efectos farmacológicos preclínicos de la lecitina de soya sobre parámetros hematológicos y marcadores inflamatorios sistémicos, contribuirá a sustentar las bases de su posible empleo como medicamento natural. Objetivo: Determinar los efectos de la lecitina de soya sobre parámetros hematológicos y marcadores inflamatorios sistémicos de ratas Wistar. Métodos: Se realizó un estudio de farmacología preclínica experimental, en el que se administró lecitina de soya en dosis máximas y mínimas a dos grupos experimentales de ratas Wistar. Se estimaron variables hematológicas para ser comparadas con el grupo control, se determinó recuento diferencial y el conteo global de leucocitos según fórmula avanzada como indicativo indirecto de inmunocompetencia. Se calcularon como marcadores inflamatorios sistémicos la relación neutrófilos-linfocitos (N/LR) y la relación plaquetas-linfocitos (P/LR). La existencia de diferencias de medianas y rangos de las diferentes variables entre los grupos se reveló mediante la Prueba de Kruskal-Wallis de muestras independientes con nivel de significancia de p <0.05. Resultados: Se observó leucopenia, aumento del recuento plaquetario y alteraciones de índices relacionados con la inflamación y la inmunidad en ambos grupos experimentales, relacionado con la dosis. La N/LR y P/LR se incrementaron de manera proporcional con la dosis y el índice de inmunidad e inflamación sistémica se incrementa con dosis mínima y tiende a decrecer con dosis máxima. Conclusiones: El producto modifica parámetros hematológicos en ratas, pero se requieren otros estudios controlados que corroboren el estado de inmunocompetencia, tomando en consideración lo que expresan los marcadores inflamatorios sistémicos.ABSTRACT Introduction: The study of the preclinical pharmacological effects of soy lecithin on hematological parameters and systemic inflammatory markers, will contribute to support the foundations of its possible use as a natural medication. Objective: To determine the effects of soy lecithin on hematological parameters and systemic inflammatory markers of Wistar rats. Methods: An experimental preclinical pharmacology study was conducted, in which soy lecithin was administered in maximum and minimum doses of two experimental Wistar rats. Hematological variables were estimated to be compared to the control group, differential counting and global leukocyte count according to advanced formula as an indirect indicative of immunocompetence was determined. The neutrophil-linfocyte (N/LR) and the platelet-linfocyte ratio (P/LR) were calculated as systemic inflammatory markers. The existence of medium and ranges differences of the different variables between the groups was revealed by the Kruskal-Wallis test of independent samples with a level of significance of p<0.05. Results: Leukopenia, increased platelet count and alterations of inflammation related to inflammation and immunity dose-related were observed in both experimental groups. The N/LR and P/LR were proportionally increased with the dose and the system of systemic immunity and inflammation is increased with minimal dose and tends to decrease with maximum dose. Conclusions: The product modifies hematological parameters in rats, but other controlled studies are required that corroborate the state of immunocompetence, taking into consideration what systemic inflammatory markers express.
       
  • Proteína C reactiva como predictor de gravedad en pacientes con
           COVID-19

    • Abstract: RESUMEN Introducción: Numerosos estudios han reportado que la gravedad de la COVID-19 está más asociada con altos niveles de proteína C reactiva que en la enfermedad no grave; sin embargo, existen controversias en los resultados. Objetivo: Determinar si la proteína C reactiva es un biomarcador de gravedad en pacientes con COVID-19. Métodos: Se realizó un estudio retrospectivo descriptivo en 148 pacientes ingresados en el Hospital Provincial General Camilo Cienfuegos de Sancti Spíritus en el mes de junio de 2021. La variable analizada fue proteína C reactiva. Se comparó la media entre grupos: graves y no graves mediante la prueba t Student para muestras independientes con un nivel de significación de 0,05. La capacidad predictora del biomarcador se determinó con el análisis de la curva ROC. Se evaluó la exactitud diagnóstica. Resultados: El valor medio de proteína C reactiva en el grupo de los graves y no graves fue 106,73 (88,43-125,03) y 26,87 (23,51-30,23), respectivamente; con diferencias altamente significativas. El área bajo la curva ROC fue de 0,991 (0,975-1,000). La mayor sensibilidad y la menor razón de falsos positivos para discriminar entre ambos grupos se encontró en 47,1 mg/L. Conclusiones: La capacidad predictora de gravedad de la prueba fue excelente. El punto de corte óptimo para definir la probabilidad de evolucionar hacia la gravedad de un paciente fue de 47,1 mg/L. La cuantificación de este parámetro bioquímico podría optimizar estrategias diagnósticas y terapéuticas.ABSTRACT Introduction: Several studies have reported that severe COVID-19 is associated with higher levels of C reactive protein than mild disease; however, there are controversy in the results. Objective: To determine whether C-reactive protein is a biomarker of severity in patients with COVID-19. Methods: A retrospective and descriptive study was carried out on 148 inpatients at Camilo Cienfuegos Hospital, in Sancti Spíritus. The variable analyzed was C-reactive protein. The mean between groups: severe and non-severe, was compared using t Student test for independent samples with a significance level of 0.05. Predictive capacity of the biomarker by ROC curve analysis was determined. Diagnostic accuracy was evaluated. Results: The mean value of C-reactive protein in the severe an non severe groups was 106.73 (88.43-125.03) and 26.87 (23.51-30.23), respectively; with highly significant differences. The area under the ROC curve was 0.991(0.975-1.000). The highest sensitivity and the lowest rate of false positive to discriminate between both groups was found at 47.1 mg/L. Conclusions: The severity predictive capacity of the test was excellent. The optimal cut-off point to define when a patient was likely to progress to severity was 47.1 mg/L. The quantification of this biochemical parameter could optimize diagnostic and therapeutic strategies.
       
  • Alteraciones de la hemostasia en pacientes graves con hemopatías
           malignas: trastornos trombóticos

    • Abstract: RESUMEN Introducción: La enfermedad trombótica asociada a las hemopatías malignas es subestimada en el paciente grave; en ocasiones queda a la sombra de las hemorragias que presentan estos enfermos. Su diagnóstico y tratamiento constituyen un desafío para lograr el aumento de la sobrevida en las unidades de cuidados críticos Objetivos: Analizar los aspectos generales de las alteraciones trombóticas en pacientes graves con hemopatías malignas. Métodos: Se realizó una investigación bibliográfico-documental acerca del tema. Se consultaron en las bases de datos de SciELO y Pubmed, los artículos publicados en los últimos diez años. Análisis y síntesis de la información: Se describen los aspectos generales vinculados con el mecanismo de la coagulación, sus criterios diagnósticos; así como la evolución del paciente con trombosis que ingresan en las unidades de cuidados intensivos. Conclusiones: El conocimiento de las alteraciones tromboembólicas en los pacientes con hemopatías malignas permite un monitoreo adecuado y la creación de estrategias individuales para mejorar la sobrevida de estos enfermos en la la unidad de cuidados intensivos.ABSTRACT Introduction: Thrombotic disease associated with malignant hemopathies is underestimated in critically ill patients; sometimes it remains in the shadow of the hemorrhages that these patients present. Its diagnosis and treatment constitute a challenge to achieve increased survival in these patients in critical care units Objectives: To analyze the general aspects of thrombotic alterations in seriously ill patients with malignant hemopathies. Methods: A bibliographical-documentary research on the subject was carried out. The SciELO and Pubmed databases of the last ten years were consulted. Analysis and synthesis of the information: General aspects related to the coagulation mechanism, its diagnostic criteria are described; as well as the evolution of the patient with thrombosis who is admitted to the intensive care unit. Conclusions: Knowledge of thromboembolic alterations in patients with malignant hemopathies allows adequate monitoring and the creation of individual strategies to improve the survival of these patients in the ICU.
       
  • Tratamiento de reemplazo enzimático en pacientes cubanos con enfermedad
           de Gaucher: experiencia de 15 años

    • Abstract: RESUMEN Introducción: La enfermedad de Gaucher es una entidad de acúmulo lisosomal, con un patrón de herencia autosómico recesivo, debido a la deficiencia de le enzima betaglucocerebrosidasa ácida. El gen está mapeado en el cromosoma 1q21 y se han descrito más de 500 mutaciones. Se caracteriza por presentar anemia, trombocitopenia, hepatoesplenomegalia, manifestaciones esqueléticas y, en ocasiones, compromiso neurológico. Entre los tratamientos se utiliza el reemplazo enzimático con imiglucerasa. Objetivo: Evaluar los resultados de la aplicación de imiglucerasa (Cerezyme®) en pacientes con enfermedad de Gaucher. Métodos: Se realiza un estudio longitudinal, descriptivo para evaluar el comportamiento de las variables clínicas, hematológicas y ultrasonográficas de ocho pacientes cubanos con enfermedad de Gaucher tras recibir el tratamiento sustitutivo enzimático. Se evaluaron al año, cinco y de diez a quince años de tratamiento. Resultados: Al inicio, todos los pacientes presentaron anemia y la mayoría tuvieron trombocitopenia y hepatoesplenomegalia al diagnóstico de la enfermedad. Los pacientes con manifestaciones neurológicas y la mutación L444P en estado homocigótico se clasificaron en EG tipo 3, el resto en tipo1. En todos los pacientes se constató aumento de las cifras de hemoglobina, la elevación del número de plaquetas y reducción de la hepatoesplenomegalia posterior al año de tratamiento. Los pacientes con tipo 3 mantuvieron la afectación neurológica. No se reportaron reacciones adversas al medicamento. Conclusiones: La terapia de reemplazo enzimática con imiglucerasa (Cerezyme®) es un pilar fundamental en el tratamiento de los pacientes con esta enfermedad, lo cual influye de forma positiva en la calidad de vida, obteniéndose mejores resultados con su comienzo en edad pediátrica.ABSTRACT Introduction: Gaucher disease is an entity of lysosomal accumulation, with an autosomal recessive inheritance pattern, due to the deficiency of the acid betaglucocerebrosidase enzyme. The gene is mapped on chromosome 1q21 and more than 500 mutations have been described. It is characterized by anemia, thrombocytopenia, hepatosplenomegaly, skeletal manifestations and sometimes neurological involvement. Among the treatments, enzyme replacement with imiglucerase is used. Objective: To evaluate the results of the application of imiglucerase in patients with Gaucher disease. Methods: A longitudinal, descriptive study to evaluate the behavior of the clinical, hematological and ultrasonographic variables of eight Cuban patients with Gaucher disease after receiving enzyme replacement treatment was carried out. They were evaluated after one, five and ten to fifteen years of treatment. Results: At debut, all patients presented anemia, and the majority showed thrombocytopenia and hepatosplenomegaly at diagnosis of the disease. Patients with neurological manifestations and the L444P mutation in a homozygous state were classified as type 3 GD, the rest as type 1. In all patients, an increase in hemoglobin levels, an increase in the number of platelets and a reduction in hepatosplenomegaly was observed after one year of treatment. Patients with type 3 maintain neurological involvement. No adverse reactions to the medication were reported. Conclusions: Enzyme replacement therapy with imiglucerase (Cerezyme®) is a fundamental pillar in the treatment of patients with this disease, which positively influences quality of life, obtaining better results with its onset in pediatric age.
       
  • Subpoblaciones de linfocitos T en adultos mayores cubanos con leucemia
           linfoide crónica

    • Abstract: RESUMEN Introducción: la inmunosenescencia está asociada con un mayor riesgo de desarrollo de cáncer. Dentro de las hemopatías malignas que afectan a este grupo de edad, está la leucemia linfoide crónica (LLC), caracterizada por trastornos en la inmunidad adaptativa que incluye las subpoblaciones de linfocitos T. Objetivo: Determinar la frecuencia de las subpoblaciones de linfocitos T en los pacientes adultos mayores con leucemia linfoide crónica evaluados en el Instituto de Hematología e Inmunología de Cuba. Métodos: Se realizó un estudio transversal en 30 adultos mayores con leucemia linfoide crónica. Se cuantificaron los linfocitos TCD3+CD4+ y TCD3+CD8+ en sangre periférica por citometría de flujo. Para la lectura y el análisis de los datos se empleó un citómetro de flujo Beckman Coulter Gallios. Se utilizaron los valores porcentuales, la media y la desviación estándar. Se consideró estadísticamente significativo si p≤0.05. Resultados: Hubo un predominio de hombres que representaron el 56,7 % y del grupo de 70-79 años de edad. No se reportó ningún adulto mayor con LLC con valores altos ni normales de linfocitos TCD3+CD4+. Predominaron los hombres con valores bajos porcentuales de linfocitos TCD3+CD4+, TCD3+CD8+ e inversión del índice CD4/CD8 en relación con las mujeres. Conclusiones: Los adultos mayores con LLC presentan alteraciones en el número de las subpoblaciones de linfocitos T. La acción de estas células en relación al crecimiento de células B malignas aún es desconocido y resulta importante determinar si esto puede reflejar un intento de evasión de las células tumorales al control inmunológico.ABSTRACT Introduction: Immunosenescence is associated with an increased risk of cancer development. Among the malignant hemopathies that affect this age group, it is chronic lymphoid leukemia (CLL), characterized by disorders in adaptive immunity, which include subpopulations of T lymphocytes. Objective: To determine frequency of T lymphocyte subpopulations in older adult patients with chronic lymphoid leukemia evaluated at the Institute of Hematology and Immunology of Cuba. Methods: A cross-sectional study was conducted in 30 older adults with chronic lymphoid leukemia. TCD3+CD4+ and TCD3+CD8+ lymphocytes were quantified in peripheral blood by flow cytometry. A Beckman Coulter Gallios flow cytometer was used to read and analyze the data. The percentage values, the mean and the standard deviation were used. It was considered statistically significant if p≤0.05. Results: There was a predominance of men who represented 56.7% and the age group of 70-79 years. No older adults with CLL with high or normal values of TCD3+CD4+ lymphocytes were reported. Men predominated with low percentage values of TCD3+CD4+, TCD3+CD8+ lymphocytes and inversion of the CD4/CD8 ratio in relation to women. Conclusions: Older adult with CLL present alterations in the number of T lymphocyte subpopulations. The role of these cells in relation to the growth of malignant B cells it is unknown and it turns out important to determine if this may reflect an attempt to evade tumor cells from immune control.
       
 
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Acta Angiologica     Open Access   (Followers: 3)
Adipocyte     Open Access  
Advances in Hematology     Open Access   (Followers: 13)
Africa Sanguine     Full-text available via subscription  
American Journal of Hematology     Hybrid Journal   (Followers: 46)
Anemia     Open Access   (Followers: 6)
Annals of Hematology     Hybrid Journal   (Followers: 14)
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Best Practice & Research Clinical Haematology     Hybrid Journal   (Followers: 5)
Blood     Hybrid Journal   (Followers: 296)
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BMJ Open Diabetes Research & Care     Open Access   (Followers: 23)
Bone Marrow Transplantation     Hybrid Journal   (Followers: 15)
British Journal of Haematology     Hybrid Journal   (Followers: 54)
Canadian Journal of Diabetes     Hybrid Journal   (Followers: 9)
Case Reports in Hematology     Open Access   (Followers: 10)
Clinical and Applied Thrombosis/Hemostasis     Open Access   (Followers: 28)
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Conquest : The Official Journal of Diabetes Australia     Full-text available via subscription   (Followers: 1)
Current Angiogenesis     Hybrid Journal   (Followers: 1)
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Egyptian Journal of Hematology and Bone Marrow Transplantation     Open Access   (Followers: 9)
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Indian Journal of Hematology and Blood Transfusion     Hybrid Journal   (Followers: 1)
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Journal of Hematological Malignancies     Open Access  
Journal of Hematology and Transfusion Medicine     Open Access   (Followers: 1)
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Journal of Social Health and Diabetes     Open Access  
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Peritoneal Dialysis International     Hybrid Journal  
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Research and Practice in Thrombosis and Haemostasis     Open Access   (Followers: 2)
Revista Cubana de Hematología, Inmunología y Hemoterapia     Open Access  
Seminars in Hematology     Hybrid Journal   (Followers: 9)
Seminars in Thrombosis and Hemostasis     Hybrid Journal   (Followers: 28)
The Lancet Haematology     Full-text available via subscription   (Followers: 43)
Therapeutic Advances in Hematology     Hybrid Journal  
Thrombosis & Haemostasis     Hybrid Journal   (Followers: 105)
Thrombosis Research     Hybrid Journal   (Followers: 30)
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Veins and Lymphatics     Open Access   (Followers: 1)

           

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