Subjects -> MEDICAL SCIENCES (Total: 8819 journals)
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CARDIOVASCULAR DISEASES (352 journals)                  1 2 | Last

Showing 1 - 200 of 352 Journals sorted alphabetically
Acta Angiologica     Open Access   (Followers: 5)
Acta Cardiologica     Hybrid Journal   (Followers: 2)
Acute Cardiac Care     Hybrid Journal   (Followers: 11)
Adipositas - Ursachen, Folgeerkrankungen, Therapie     Hybrid Journal   (Followers: 1)
AJP Heart and Circulatory Physiology     Hybrid Journal   (Followers: 13)
Aktuelle Kardiologie     Hybrid Journal   (Followers: 2)
American Heart Journal     Hybrid Journal   (Followers: 64)
American Journal of Cardiology     Hybrid Journal   (Followers: 74)
American Journal of Cardiovascular Drugs     Hybrid Journal   (Followers: 22)
American Journal of Hypertension     Hybrid Journal   (Followers: 31)
American Journal of Preventive Cardiology     Open Access   (Followers: 3)
Anales de Cirugia Vascular     Full-text available via subscription   (Followers: 1)
Anatolian Journal of Cardiology     Open Access   (Followers: 6)
Angiología     Full-text available via subscription  
Angiologia e Cirurgia Vascular     Open Access   (Followers: 1)
Angiology     Hybrid Journal   (Followers: 5)
Annales de Cardiologie et d'Angéiologie     Full-text available via subscription   (Followers: 1)
Annals of Circulation     Open Access   (Followers: 2)
Annals of Noninvasive Electrocardiology     Hybrid Journal   (Followers: 1)
Annals of Pediatric Cardiology     Open Access   (Followers: 14)
AORTA     Open Access   (Followers: 1)
Archives of Cardiovascular Diseases     Full-text available via subscription   (Followers: 6)
Archives of Cardiovascular Diseases Supplements     Full-text available via subscription   (Followers: 4)
Archives of Cardiovascular Imaging     Open Access   (Followers: 2)
Archivos de cardiología de México     Open Access   (Followers: 2)
Argentine Journal of Cardiology (English edition)     Open Access   (Followers: 3)
Arquivos Brasileiros de Cardiologia     Open Access   (Followers: 2)
Arrhythmia & Electrophysiology Review     Open Access  
Arteriosclerosis, Thrombosis and Vascular Biology     Full-text available via subscription   (Followers: 34)
Artery Research     Hybrid Journal   (Followers: 5)
ARYA Atherosclerosis     Open Access  
ASAIO Journal     Hybrid Journal   (Followers: 3)
ASEAN Heart Journal     Open Access   (Followers: 3)
Asian Cardiovascular and Thoracic Annals     Hybrid Journal   (Followers: 2)
Aswan Heart Centre Science & Practice Services     Open Access   (Followers: 1)
Atherosclerosis : X     Open Access  
Bangladesh Heart Journal     Open Access   (Followers: 3)
Basic Research in Cardiology     Hybrid Journal   (Followers: 10)
BMC Cardiovascular Disorders     Open Access   (Followers: 25)
Brain Circulation     Open Access   (Followers: 1)
British Journal of Cardiology     Full-text available via subscription   (Followers: 18)
Canadian Journal of Cardiology     Hybrid Journal   (Followers: 17)
Cardiac Cath Lab Director     Full-text available via subscription   (Followers: 1)
Cardiac Electrophysiology Review     Hybrid Journal   (Followers: 3)
Cardiac Failure Review     Open Access   (Followers: 3)
Cardiocore     Full-text available via subscription   (Followers: 1)
Cardiogenetics     Open Access   (Followers: 4)
Cardiology     Full-text available via subscription   (Followers: 20)
Cardiology and Angiology: An International Journal     Open Access   (Followers: 1)
Cardiology and Therapy     Open Access   (Followers: 12)
Cardiology Clinics     Full-text available via subscription   (Followers: 14)
Cardiology in Review     Hybrid Journal   (Followers: 9)
Cardiology in the Young     Hybrid Journal   (Followers: 35)
Cardiology Journal     Open Access   (Followers: 6)
Cardiology Plus     Open Access   (Followers: 1)
Cardiology Research     Open Access   (Followers: 16)
Cardiology Research and Practice     Open Access   (Followers: 11)
Cardiopulmonary Physical Therapy Journal     Hybrid Journal   (Followers: 12)
Cardiorenal Medicine     Full-text available via subscription   (Followers: 1)
Cardiothoracic Surgeon     Open Access   (Followers: 1)
CardioVasc     Full-text available via subscription   (Followers: 1)
Cardiovascular & Haematological Disorders - Drug Targets     Hybrid Journal   (Followers: 2)
Cardiovascular & Hematological Agents in Medicinal Chemistry     Hybrid Journal   (Followers: 1)
CardioVascular and Interventional Radiology     Hybrid Journal   (Followers: 15)
Cardiovascular and Thoracic Open     Open Access  
Cardiovascular Diabetology     Open Access   (Followers: 10)
Cardiovascular Drugs and Therapy     Hybrid Journal   (Followers: 16)
Cardiovascular Endocrinology & Metabolism     Hybrid Journal   (Followers: 1)
Cardiovascular Engineering     Hybrid Journal   (Followers: 2)
Cardiovascular Engineering and Technology     Hybrid Journal   (Followers: 2)
Cardiovascular Intervention and Therapeutics     Hybrid Journal   (Followers: 6)
Cardiovascular Journal     Open Access   (Followers: 7)
Cardiovascular Journal of Africa     Full-text available via subscription   (Followers: 5)
Cardiovascular Journal of South Africa     Full-text available via subscription   (Followers: 2)
Cardiovascular Medicine in General Practice     Full-text available via subscription   (Followers: 7)
Cardiovascular Pathology     Hybrid Journal   (Followers: 4)
Cardiovascular Regenerative Medicine     Open Access  
Cardiovascular Research     Hybrid Journal   (Followers: 19)
Cardiovascular Revascularization Medicine     Hybrid Journal   (Followers: 1)
Cardiovascular System     Open Access  
Cardiovascular Therapeutics     Open Access   (Followers: 2)
Cardiovascular Toxicology     Hybrid Journal   (Followers: 8)
Cardiovascular Ultrasound     Open Access   (Followers: 5)
CASE : Cardiovascular Imaging Case Reports     Open Access  
Case Reports in Cardiology     Open Access   (Followers: 8)
Catheterization and Cardiovascular Interventions     Hybrid Journal   (Followers: 5)
Cerebrovascular Diseases     Full-text available via subscription   (Followers: 3)
Cerebrovascular Diseases Extra     Open Access  
Chest     Full-text available via subscription   (Followers: 114)
Choroby Serca i Naczyń     Open Access   (Followers: 1)
Circulation     Hybrid Journal   (Followers: 292)
Circulation : Cardiovascular Imaging     Hybrid Journal   (Followers: 18)
Circulation : Cardiovascular Interventions     Hybrid Journal   (Followers: 23)
Circulation : Cardiovascular Quality and Outcomes     Hybrid Journal   (Followers: 15)
Circulation : Genomic and Precision Medicine     Hybrid Journal   (Followers: 17)
Circulation : Heart Failure     Hybrid Journal   (Followers: 33)
Circulation Research     Hybrid Journal   (Followers: 37)
Cirugía Cardiovascular     Open Access  
CJC Open     Open Access   (Followers: 1)
Clínica e Investigación en Arteriosclerosis     Hybrid Journal  
Clínica e Investigación en arteriosclerosis (English Edition)     Hybrid Journal  
Clinical and Experimental Hypertension     Hybrid Journal   (Followers: 3)
Clinical Cardiology     Hybrid Journal   (Followers: 10)
Clinical Hypertension     Open Access   (Followers: 5)
Clinical Medicine Insights : Cardiology     Open Access   (Followers: 7)
Clinical Medicine Reviews in Cardiology     Hybrid Journal   (Followers: 1)
Clinical Research in Cardiology     Hybrid Journal   (Followers: 5)
Clinical Research in Cardiology Supplements     Hybrid Journal  
Clinical Trials and Regulatory Science in Cardiology     Open Access   (Followers: 4)
Congenital Heart Disease     Hybrid Journal   (Followers: 7)
Congestive Heart Failure     Hybrid Journal   (Followers: 4)
Cor et Vasa     Full-text available via subscription   (Followers: 2)
Coronary Artery Disease     Hybrid Journal   (Followers: 2)
CorSalud     Open Access  
Critical Pathways in Cardiology     Hybrid Journal   (Followers: 4)
Current Cardiology Reports     Hybrid Journal   (Followers: 6)
Current Cardiology Reviews     Hybrid Journal   (Followers: 3)
Current Cardiovascular Imaging Reports     Hybrid Journal   (Followers: 1)
Current Cardiovascular Risk Reports     Hybrid Journal  
Current Heart Failure Reports     Hybrid Journal   (Followers: 5)
Current Hypertension Reports     Hybrid Journal   (Followers: 6)
Current Hypertension Reviews     Hybrid Journal   (Followers: 6)
Current Opinion in Cardiology     Hybrid Journal   (Followers: 13)
Current Problems in Cardiology     Hybrid Journal   (Followers: 3)
Current Research : Cardiology     Full-text available via subscription   (Followers: 1)
Current Treatment Options in Cardiovascular Medicine     Hybrid Journal   (Followers: 3)
Current Vascular Pharmacology     Hybrid Journal   (Followers: 5)
CVIR Endovascular     Open Access   (Followers: 1)
Der Kardiologe     Hybrid Journal   (Followers: 1)
Echo Research and Practice     Open Access   (Followers: 2)
Echocardiography     Hybrid Journal   (Followers: 4)
Egyptian Heart Journal     Open Access   (Followers: 2)
Egyptian Journal of Cardiothoracic Anesthesia     Open Access  
ESC Heart Failure     Open Access   (Followers: 5)
European Cardiology Review     Open Access   (Followers: 1)
European Heart Journal     Hybrid Journal   (Followers: 77)
European Heart Journal - Cardiovascular Imaging     Hybrid Journal   (Followers: 11)
European Heart Journal - Cardiovascular Pharmacotherapy     Full-text available via subscription   (Followers: 3)
European Heart Journal - Quality of Care and Clinical Outcomes     Hybrid Journal   (Followers: 1)
European Heart Journal : Acute Cardiovascular Care     Hybrid Journal   (Followers: 1)
European Heart Journal : Case Reports     Open Access   (Followers: 2)
European Heart Journal Supplements     Hybrid Journal   (Followers: 7)
European Journal of Cardio-Thoracic Surgery     Hybrid Journal   (Followers: 10)
European Journal of Cardio-Thoracic Surgery Supplements     Full-text available via subscription   (Followers: 2)
European Journal of Cardiovascular Nursing     Hybrid Journal   (Followers: 5)
European Journal of Heart Failure     Hybrid Journal   (Followers: 15)
European Journal of Preventive Cardiology.     Hybrid Journal   (Followers: 6)
European Stroke Organisation     Hybrid Journal   (Followers: 7)
Experimental & Translational Stroke Medicine     Open Access   (Followers: 10)
Expert Review of Cardiovascular Therapy     Full-text available via subscription   (Followers: 4)
Folia Cardiologica     Open Access  
Forum Zaburzeń Metabolicznych     Hybrid Journal  
Frontiers in Cardiovascular Medicine     Open Access   (Followers: 1)
Future Cardiology     Hybrid Journal   (Followers: 5)
General Thoracic and Cardiovascular Surgery     Hybrid Journal   (Followers: 4)
Global Cardiology Science and Practice     Open Access   (Followers: 5)
Global Heart     Hybrid Journal   (Followers: 3)
Heart     Hybrid Journal   (Followers: 53)
Heart and Mind     Open Access  
Heart and Vessels     Hybrid Journal  
Heart Failure Clinics     Full-text available via subscription   (Followers: 4)
Heart Failure Reviews     Hybrid Journal   (Followers: 3)
Heart India     Open Access   (Followers: 2)
Heart International     Full-text available via subscription  
Heart Rhythm     Hybrid Journal   (Followers: 16)
Heart Rhythm O2     Full-text available via subscription   (Followers: 3)
Heart Views     Open Access   (Followers: 2)
HeartRhythm Case Reports     Open Access   (Followers: 1)
Hearts     Open Access   (Followers: 3)
Hellenic Journal of Cardiology     Open Access   (Followers: 2)
Herz     Hybrid Journal   (Followers: 2)
High Blood Pressure & Cardiovascular Prevention     Full-text available via subscription   (Followers: 3)
Hypertension     Full-text available via subscription   (Followers: 26)
Hypertension     Open Access   (Followers: 2)
Hypertension in Pregnancy     Hybrid Journal   (Followers: 10)
Hypertension Research     Hybrid Journal   (Followers: 4)
Ibrahim Cardiac Medical Journal     Open Access   (Followers: 1)
IJC Heart & Vessels     Open Access   (Followers: 2)
IJC Heart & Vasculature     Open Access   (Followers: 1)
IJC Metabolic & Endocrine     Open Access   (Followers: 1)
Indian Heart Journal     Open Access   (Followers: 5)
Indian Journal of Cardiovascular Disease in Women WINCARS     Open Access   (Followers: 1)
Indian Journal of Clinical Cardiology     Open Access   (Followers: 1)
Indian Journal of Thoracic and Cardiovascular Surgery     Hybrid Journal  
Indian Pacing and Electrophysiology Journal     Open Access   (Followers: 1)
Innovations : Technology and Techniques in Cardiothoracic and Vascular Surgery     Hybrid Journal   (Followers: 2)
Insuficiencia Cardíaca     Open Access  
Interactive CardioVascular and Thoracic Surgery     Hybrid Journal   (Followers: 7)
International Cardiovascular Forum Journal     Open Access  
International Journal of Angiology     Hybrid Journal  
International Journal of Cardiology     Hybrid Journal   (Followers: 18)
International Journal of Cardiology Hypertension     Open Access   (Followers: 1)
International Journal of Cardiovascular and Cerebrovascular Disease     Open Access   (Followers: 3)
International Journal of Cardiovascular Imaging     Hybrid Journal   (Followers: 2)
International Journal of Cardiovascular Research     Hybrid Journal   (Followers: 6)
International Journal of Heart Rhythm     Open Access  
International Journal of Hypertension     Open Access   (Followers: 8)
International Journal of Hyperthermia     Open Access  
International Journal of Stroke     Hybrid Journal   (Followers: 36)
International Journal of the Cardiovascular Academy     Open Access  

        1 2 | Last

Similar Journals
Journal Cover
European Journal of Preventive Cardiology.
Journal Prestige (SJR): 2.037
Citation Impact (citeScore): 4
Number of Followers: 6  
 
Hybrid Journal Hybrid journal   * Containing 2 Open Access Open Access article(s) in this issue *
ISSN (Print) 2047-4873 - ISSN (Online) 2047-4881
Published by Sage Publications Homepage  [1162 journals]
  • The MECKI score initiative: a successful and ongoing story

    • Free pre-print version: Loading...

      Authors: Massimo F Piepoli, Ugo Corrà, Piergiuseppe Agostoni
      Pages: 3 - 4
      Abstract: European Journal of Preventive Cardiology, Volume 27, Issue 2_suppl, Page 3-4, December 2020.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-11-26T09:22:44Z
      DOI: 10.1177/2047487320952692
      Issue No: Vol. 27, No. 2_suppl (2020)
       
  • The MECKI score initiative: Development and state of the art

    • Free pre-print version: Loading...

      Authors: Elisabetta Salvioni, Alice Bonomi, Federica Re, Massimo Mapelli, Irene Mattavelli, Giuseppe Vitale, Filippo M Sarullo, Pietro Palermo, Fabrizio Veglia, Piergiuseppe Agostoni
      Pages: 5 - 11
      Abstract: European Journal of Preventive Cardiology, Volume 27, Issue 2_suppl, Page 5-11, December 2020.
      The high morbidity and poor survival rates associated with chronic heart failure still represent a big challenge, despite improvements in treatments and the development of new therapeutic opportunities. The prediction of outcome in heart failure is gradually moving towards a multiparametric approach in order to obtain more accurate models and to tailor the prognostic evaluation to the individual characteristics of a single subject. The Metabolic Exercise test data combined with Cardiac and Kidney Indexes (MECKI) score was developed 10 years ago from 2715 patients and subsequently validated in a different population. The score allows an accurate evaluation of the risk of heart failure patients using only six variables that include the evaluation of the exercise capacity (peak oxygen uptake and ventilation/CO2 production slope), blood samples (haemoglobin, Na+, Modification of Diet in Renal Disease) and echocardiography (left ventricular ejection fraction). Over the following years, the MECKI score was tested taking into account therapies and specific markers of heart failure, and it proved to be a simple, useful tool for risk stratification and for therapeutic strategies in heart failure patients. The close connection between the centres involved and the continuous updating of the data allow the participating sites to propose substudies on specific subpopulations based on a common dataset and to put together and develop new ideas and perspectives.
      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-11-26T09:22:22Z
      DOI: 10.1177/2047487320959010
      Issue No: Vol. 27, No. 2_suppl (2020)
       
  • Comparison among different multiparametric scores for risk stratification
           in heart failure patients with reduced ejection fraction

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      Authors: Ugo Corrà, Alessandra Magini, Stefania Paolillo, Maria Frigerio
      Pages: 12 - 18
      Abstract: European Journal of Preventive Cardiology, Volume 27, Issue 2_suppl, Page 12-18, December 2020.
      Heart failure is a serious condition with high prevalence (about 2% in the adult population in developed countries, and more than 8% in patients older than 75 years). About 3–5% of hospital admissions are linked with heart failure incidents. The guidelines of the European Society of Cardiology for the diagnosis and treatment of acute and chronic heart failure have identified individual markers in patients with heart failure, including demographic data, aetiology, comorbidities, clinical, radiological, haemodynamic, echocardiographic and biochemical parameters. Several scoring systems have been proposed to identify adverse events, such as destabilizations, re-hospitalizations and mortality. This article reviews scoring systems for heart failure prognostication, with particular mention of those models with exercise tolerance objective definition. Although most of the models include readily available clinical information, quite a few of them comprise circulating levels of natriuretic peptides and a more objective evaluation of exercise tolerance. A literature review was also conducted to (a) identify heart failure risk-prediction models, (b) assess statistical approach, and (c) identify common variables.
      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-11-26T09:22:28Z
      DOI: 10.1177/2047487320962990
      Issue No: Vol. 27, No. 2_suppl (2020)
       
  • Roles of periodic breathing and isocapnic buffering period during exercise
           in heart failure

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      Authors: Piergiuseppe Agostoni, Michele Emdin, Fabiana De Martino, Anna Apostolo, Marco Masè, Mauro Contini, Cosimo Carriere, Carlo Vignati, Gianfranco Sinagra
      Pages: 19 - 26
      Abstract: European Journal of Preventive Cardiology, Volume 27, Issue 2_suppl, Page 19-26, December 2020.
      In heart failure, exercise – induced periodic breathing and end tidal carbon dioxide pressure value during the isocapnic buffering period are two features identified at cardiopulmonary exercise testing strictly related to sympathetic activation. In the present review we analysed the physiology behind periodic breathing and the isocapnic buffering period and present the relevant prognostic value of both periodic breathing and the presence/absence of the identifiable isocapnic buffering period.
      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-11-26T09:22:32Z
      DOI: 10.1177/2047487320952029
      Issue No: Vol. 27, No. 2_suppl (2020)
       
  • Role of comorbidities in heart failure prognosis Part I: Anaemia, iron
           deficiency, diabetes, atrial fibrillation

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      Authors: Stefania Paolillo, Angela B Scardovi, Jeness Campodonico
      Pages: 27 - 34
      Abstract: European Journal of Preventive Cardiology, Volume 27, Issue 2_suppl, Page 27-34, December 2020.
      Cardiovascular and non-cardiovascular comorbidities are frequently observed in heart failure patients, complicating the therapeutic management and leading to poor prognosis. The prompt recognition of associated comorbid conditions is of great importance to optimize the clinical management, the follow-up, and the treatment of patients affected by chronic heart failure. Anaemia and iron deficiency are commonly reported in all heart failure forms, have a multifactorial aetiology and are responsible for reduced exercise tolerance, impaired quality of life, and poor long-term prognosis. Diabetes mellitus is highly prevalent in heart failure and a poor glycaemic control is associated with worst outcome. Two specific heart failure forms are usually observed in diabetic patients: an ischaemic cardiomyopathy or a typical diabetic cardiomyopathy. The implementation of use of sodium-glucose cotransporter-2 inhibitors will much improve in the near future the long-term prognosis of patients affected by heart failure and diabetes. Among cardiovascular comorbidities, atrial fibrillation is the most common arrhythmic disease of heart failure patients and it is still not clear whether its presence should be considered as a prognostic indicator or as a marker of advanced disease. The aim of the present review was to explore the clinical and prognostic impact of anaemia and iron deficiency, diabetes mellitus, and atrial fibrillation in patients affected by chronic heart failure.
      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-11-26T09:22:06Z
      DOI: 10.1177/2047487320960288
      Issue No: Vol. 27, No. 2_suppl (2020)
       
  • Role of comorbidities in heart failure prognosis Part 2: Chronic kidney
           disease, elevated serum uric acid

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      Authors: Andrea Tedeschi, Piergiuseppe Agostoni, Beatrice Pezzuto, Ugo Corra’, Domenico Scrutinio, Rocco La Gioia, Rosa Raimondo, Andrea Passantino, Massimo F Piepoli
      Pages: 35 - 45
      Abstract: European Journal of Preventive Cardiology, Volume 27, Issue 2_suppl, Page 35-45, December 2020.
      Despite improvements in pharmacotherapy, morbidity and mortality rates in community-based populations with chronic heart failure still remain high. The increase in medical complexity among patients with heart failure may be reflected by an increase in concomitant non-cardiovascular comorbidities, which are recognized as independent prognostic factors in this population. Heart failure and chronic kidney disease share many risk factors, and often coexist. The presence of kidney failure is associated with incremented risk of cardiovascular and non-cardiovascular mortality in heart failure patients. Chronic kidney disease is also linked with underutilization of evidence-based heart failure therapy that may reduce morbidity and mortality. More targeted therapies would be important to improve the prognosis of patients with these diseases. In recent years, serum uric acid as a determinant of cardiovascular risk has gained interest. Epidemiological, experimental and clinical data show that patients with hyperuricaemia are at increased risk of cardiac, renal and vascular damage and cardiovascular events. Moreover, elevated serum uric acid predicts worse outcome in both acute and chronic heart failure. While studies have raised the possibility of preventing heart failure through the use of uric acid lowering agents, the literature is still inconclusive on whether the reduction in uric acid will result in a measurable clinical benefit. Available evidences suggest that chronic kidney disease and elevated uric acid could worsen heart failure patients’ prognosis. The aim of this review is to analyse a possible utilization of these comorbidities in risk stratification and as a therapeutic target to get a prognostic improvement in heart failure patients.
      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-11-26T09:22:18Z
      DOI: 10.1177/2047487320957793
      Issue No: Vol. 27, No. 2_suppl (2020)
       
  • Role of gender, age and BMI in prognosis of heart failure

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      Authors: Susanna Sciomer, Federica Moscucci, Elisabetta Salvioni, Giovanni Marchese, Maurizio Bussotti, Ugo Corrà, Massimo F Piepoli
      Pages: 46 - 51
      Abstract: European Journal of Preventive Cardiology, Volume 27, Issue 2_suppl, Page 46-51, December 2020.
      The prognostic stratification of heart failure remains an urgent need for correct clinical management of the affected patients. In fact, due to the high mortality and morbidity rates, heart failure constantly requires an updated and careful management of all aspects that characterise the disease. In addition to the well-known clinical, laboratory and instrumental characteristics that affect the prognosis of heart failure, gender, age and body mass index have a different impact and deserve specific insights and clarifications. At this scope, the metabolic exercise cardiac kidney index score research group has produced several works in the past, trying to identify the role of these specific factors on the prognosis of heart failure. In particular, the different performances in the cardiopulmonary exercise test of specific categories of heart failure patients, such as women, elderly and obese or overweight individuals, have requested dedicated evaluations of metabolic exercise cardiac kidney index score power.
      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-11-26T09:22:30Z
      DOI: 10.1177/2047487320961980
      Issue No: Vol. 27, No. 2_suppl (2020)
       
  • Risk stratification in cardiomyopathy

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      Authors: Gianfranco Sinagra, Cosimo Carriere, Francesco Clemenza, Chiara Minà, Francesco Bandera, Denise Zaffalon, Paola Gugliandolo, Marco Merlo, Marco Guazzi, Piergiuseppe Agostoni
      Pages: 52 - 58
      Abstract: European Journal of Preventive Cardiology, Volume 27, Issue 2_suppl, Page 52-58, December 2020.
      Prognostic stratification of cardiomyopathies represents a cornerstone for the appropriate management of patients and is focused mainly on arrhythmic events and heart failure. Cardiopulmonary exercise testing provides additional prognostic information, particularly in the setting of heart failure. Cardiopulmonary exercise testing data, integrated in scores such as the Metabolism Exercise Cardiac Kidney Index score have been shown to improve the risk stratification of these patients. Cardiopulmonary exercise testing has been analysed as a potential supplier of prognostic parameters in the context of hypertrophic cardiomyopathy, for which it has been shown that a reduced oxygen consumption peak, an increased ventilation/carbon dioxide production slope and chronotropic incompetence correlate with a worse prognosis. To a lesser extent, in dilated cardiomyopathy, it has been shown that the percentage of oxygen consumption peak, not the pure value, and the ventilation/carbon dioxide production slope are associated with a greater cardiovascular risk. Few data are available about other cardiomyopathies (arrhythmogenic and restrictive). Cardiomyopathy patients should be early and routinely referred to heart failure advanced centres in order to perform a comprehensive risk stratification which should include a cardiopulmonary exercise test, with variables and cut-offs shown to improve their risk stratification.
      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-11-26T09:22:49Z
      DOI: 10.1177/2047487320961898
      Issue No: Vol. 27, No. 2_suppl (2020)
       
  • Risk stratification in heart failure with mild reduced ejection fraction

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      Authors: Damiano Magrì, Giovanna Gallo, Gianfranco Parati, Mariantonietta Cicoira, Michele Senni
      Pages: 59 - 64
      Abstract: European Journal of Preventive Cardiology, Volume 27, Issue 2_suppl, Page 59-64, December 2020.
      Heart failure with mid-range ejection fraction represents a heterogeneous and relatively young heart failure category accounting for nearly 20–30% of the overall heart failure population. Due to its complex phenotype, a reliable clinical picture of heart failure with mid-range ejection fraction patients as well as a definite risk stratification are still relevant unsolved issues. In such a context, there is growing interest in a comprehensive functional assessment by means of a cardiopulmonary exercise test, yet considered a cornerstone in the clinical management of patients with heart failure and reduced ejection fraction. Indeed, the cardiopulmonary exercise test has also been found to be particularly useful in the heart failure with mid-range ejection fraction category, several cardiopulmonary exercise test-derived parameters being associated with a poor outcome. In particular, a recent contribution by the metabolic exercise combined with cardiac and kidney indexes research group showed an independent association between the peak oxygen uptake and pure cardiovascular mortality in a large cohort of recovered heart failure with mid-range ejection fraction patients. Contextually, the same study supplied an easy approach to identify a high-risk heart failure with mid-range ejection fraction subset by using a combination of peak oxygen uptake and ventilatory efficiency cut-off values, namely 55% of the maximum predicted and 31, respectively. Thus, looking at the above-mentioned promising results and waiting for specific trials, it is reasonable to consider cardiopulmonary exercise test assessment as part of the heart failure with mid-range ejection fraction work-up in order to identify those patients with an unfavourable functional profile who probably deserve a close clinical follow-up and, probably, more aggressive therapeutic strategies.
      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-11-26T09:22:45Z
      DOI: 10.1177/2047487320951104
      Issue No: Vol. 27, No. 2_suppl (2020)
       
  • Beta-blockers in heart failure prognosis: Lessons learned by MECKI Score
           Group papers

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      Authors: Gaia Cattadori, Silvia Di Marco, Stefania Farina, Giuseppe Limongelli, Emanuele Monda, Roberto Badagliacca, Silvia Papa, Lucia Tricarico, Michele Correale
      Pages: 65 - 71
      Abstract: European Journal of Preventive Cardiology, Volume 27, Issue 2_suppl, Page 65-71, December 2020.
      Heart failure is a complex syndrome affecting several organs including kidney, lungs, liver, brain muscles and sympathetic system. Each of these organs might contribute to its severity and prognosis. The prognosis assessment is critical for a correct heart failure management. It has already been demonstrated that a single parameter is weaker for prognosis than different parameters combined. The Metabolic Exercise test data combined with Cardiac and Kidney Indexes (MECKI) score has been built and validated for heart failure with reduced ejection fraction (HFrEF) patients by considering cardiopulmonary exercise test data combined with clinical, laboratory and echocardiographic measurements. The betablockers treatment is a milestone in the HFrEF management. In the MECKI score database, the association of betablockers treatment with outcome has been investigated in different settings.
      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-11-26T09:22:12Z
      DOI: 10.1177/2047487320951109
      Issue No: Vol. 27, No. 2_suppl (2020)
       
  • Future developments in the MECKI score initiative

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      Authors: Andrew JS Coats
      Pages: 72 - 75
      Abstract: European Journal of Preventive Cardiology, Volume 27, Issue 2_suppl, Page 72-75, December 2020.
      The Metabolic Exercise combined with Cardiac and Kidney Indexes [MECKI) score is a validated prognostic score for heart failure with reduced ejection fraction which combines commonly available clinical and metabolic parameters with two cardiopulmonary exercise test derived prognostic measurements. It has been validated to predict prognosis and to aid clinical decision making and it has been shown to be superior in predicting mortality compared with other commonly used prognostic scores for heart failure. In the future it would be valuable to establish whether the score holds true also in other settings, and in particular in under-represented groups – the elderly, women, and people of different ethnic backgrounds – and in other heart failure syndromes. In future it may be extended to assess its value in the presence of a range of co-morbidities such as chronic obstructive pulmonary disease, pulmonary hypertension and frailty and cachexia as well as in other conditions such as hypertrophic cardiomyopathy, amyloid, asymptomatic left ventricular dysfunction and hypertension. It may also be a candidate end-point for adaptive trials designed to prove an improvement in the MECKI score as an approvable interim end-point whilst larger mortality and morbidity trials are still underway.
      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-11-26T09:22:09Z
      DOI: 10.1177/2047487320962983
      Issue No: Vol. 27, No. 2_suppl (2020)
       
  • Editors’ presentation: Focus on short communications in
           cardiovascular prevention

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      Authors: Geza Halasz, Massimo F Piepoli
      Pages: 2031 - 2032
      Abstract: European Journal of Preventive Cardiology, Volume 27, Issue 19, Page 2031-2032, December 2020.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-12-11T05:51:25Z
      DOI: 10.1177/2047487320978108
      Issue No: Vol. 27, No. 19 (2020)
       
  • Editors’ presentation: Focus on diabetes mellitus and diet

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      Authors: Geza Halasz, Massimo F Piepoli
      Pages: 1915 - 1918
      Abstract: European Journal of Preventive Cardiology, Volume 27, Issue 18, Page 1915-1918, December 2020.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-11-17T10:52:31Z
      DOI: 10.1177/2047487320969012
      Issue No: Vol. 27, No. 18 (2020)
       
  • CORRIGENDUM: The effects and costs of home-based rehabilitation for heart
           failure with reduced ejection fraction: The REACH-HF multicentre
           randomized controlled trial

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      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-11-10T06:58:49Z
      DOI: 10.1177/2047487320974256
       
  • Success factors in high-effect, low-cost eHealth programs for patients
           with hypertension: a systematic review and meta-analysis

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      Authors: Sebastiaan Blok, Eva L van der Linden, G Aernout Somsen, Igor I Tulevski, Michiel M Winter, Bert-Jan H van den Born
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.
      BackgroundeHealth programs can lower blood pressure but also drive healthcare costs. This study aims to review the evidence on the effectiveness and costs of eHealth for hypertension and assess commonalities in programs with high effect and low additional cost.ResultsOverall, the incremental decrease in systolic blood pressure using eHealth, compared to usual care, was 3.87 (95% confidence interval (CI) 2.98–4.77) mmHg at 6 months and 5.68 (95% CI 4.77–6.59) mmHg at 12 months’ follow-up. High intensity interventions were more effective, resulting in a 2.6 (95% CI 0.5–4.7) (at 6 months) and 3.3 (95% CI 1.4–5.1) (at 12 months) lower systolic blood pressure, but were also more costly, resulting in €170 (95% CI 56–284) higher costs at 6 months and €342 (95% CI 128–556) at 12 months. Programs that included a high volume of participants showed €203 (95% CI 99–307) less costs than those with a low volume at 6 months, and €525 (95% CI 299–751) at 12 months without showing a difference in systolic blood pressure. Studies that implemented eHealth as a partial replacement, rather than addition to usual care, were also less costly (€119 (95% CI –38–201 at 6 months) and €346 (95% CI 261–430 at 12 months)) without being less effective. Evidence on eHealth programs for hypertension is ambiguous, heterogeneity on effectiveness and costs is high (I2 = 56–98%).ConclusionEffective eHealth with limited additional costs should focus on high intensity interventions, involve a large number of participants and use eHealth as a partial replacement for usual care.
      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-09-11T04:57:08Z
      DOI: 10.1177/2047487320957170
       
  • Exercise in hypertrophic cardiomyopathy: towards a personalised approach

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      Authors: Matthias Wilhelm
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-09-04T04:34:05Z
      DOI: 10.1177/2047487320957792
       
  • Trends in cardiovascular diseases burden and vascular risk factors in
           Italy: The Global Burden of Disease study 1990–2017

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      Authors: Paolo A Cortesi, Carla Fornari, Fabiana Madotto, Sara Conti, Mohsen Naghavi, Boris Bikbov, Paul S Briant, Valeria Caso, Giacomo Crotti, Catherine Johnson, Minh Nguyen, Luigi Palmieri, Norberto Perico, Francesco Profili, Giuseppe Remuzzi, Gregory A Roth, Eugenio Traini, Fabio Voller, Simon Yadgir, Giampiero Mazzaglia, Lorenzo Monasta, Simona Giampaoli, Lorenzo G Mantovani
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.
      AimsAn exhaustive and updated estimation of cardiovascular disease burden and vascular risk factors is still lacking in European countries. This study aims to fill this gap assessing the global Italian cardiovascular disease burden and its changes from 1990 to 2017 and comparing the Italian situation with European countries.MethodsAll accessible data sources from the 2017 Global Burden of Disease study were used to estimate the cardiovascular disease prevalence, mortality and disability-adjusted life years and cardiovascular disease attributable risk factors burden in Italy from 1990 to 2017. Furthermore, we compared the cardiovascular disease burden within the 28 European Union countries.ResultsSince 1990, we observed a significant decrease of cardiovascular disease burden, particularly in the age-standardised prevalence (–12.7%), mortality rate (–53.8%), and disability-adjusted life years rate (–55.5%). Similar improvements were observed in the majority of European countries. However, we found an increase in all-ages prevalence of cardiovascular diseases from 5.75 m to 7.49 m Italian residents. Cardiovascular diseases still remain the first cause of death (34.8% of total mortality). More than 80% of the cardiovascular disease burden could be attributed to known modifiable risk factors such as high systolic blood pressure, dietary risks, high low density lipoprotein cholesterol, and impaired kidney function.ConclusionsOur study shows a decline in cardiovascular mortality and disability-adjusted life years, which reflects the success in reducing disability, premature death and early incidence of cardiovascular diseases. However, the burden of cardiovascular diseases is still high. An approach that includes the cooperation and coordination of all stakeholders of the Italian National Health System is required to further reduce this burden.
      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-08-25T04:56:38Z
      DOI: 10.1177/2047487320949414
       
  • Association between change in cardiorespiratory fitness and incident
           hypertension in Swedish adults

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      Authors: Tobias Holmlund, Björn Ekblom, Mats Börjesson, Gunnar Andersson, Peter Wallin, Elin Ekblom-Bak
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.
      AimsTo explore how change in cardiorespiratory fitness is associated with incident hypertension in adults, and whether the association varies between sex, age, body mass index, cardiorespiratory fitness at baseline and follow-up time. A second aim is to study how change in other lifestyle-related variables affects the results.MethodsA total of 91,728 participants (48% women), normotensive at baseline, with two examinations from occupational health service screenings between 1982 and 2019 (mean duration 4.3 years) were included. Cardiorespiratory fitness was assessed as estimated maximal oxygen consumption using submaximal cycle testing. Change in cardiorespiratory fitness was expressed as the percentage change per year. Incident hypertension was defined as systolic blood pressure of 140 mmHg or greater or diastolic blood pressure of 90 mmHg or greater, or self-reported physician-diagnosed hypertension, at second examination.ResultsA large increase (≥3% annual change) in cardiorespiratory fitness was associated with a 11% lower risk of incident hypertension compared with maintainers (–1 to +1%), after multi-adjustment including change in smoking, body mass index, diet, stress and exercise habits. On the contrary, a small (–1 to −
      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-08-19T01:24:16Z
      DOI: 10.1177/2047487320942997
       
  • Detecting undiagnosed atrial fibrillation in UK primary care: Validation
           of a machine learning prediction algorithm in a retrospective cohort study
           

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      Authors: Sara Sekelj, Belinda Sandler, Ellie Johnston, Kevin G Pollock, Nathan R Hill, Jason Gordon, Carmen Tsang, Sadia Khan, Fu Siong Ng, Usman Farooqui
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.
      AimsTo evaluate the ability of a machine learning algorithm to identify patients at high risk of atrial fibrillation in primary care.MethodsA retrospective cohort study was undertaken using the DISCOVER registry to validate an algorithm developed using a Clinical Practice Research Datalink (CPRD) dataset. The validation dataset included primary care patients in London, England aged ≥30 years from 1 January 2006 to 31 December 2013, without a diagnosis of atrial fibrillation in the prior 5 years. Algorithm performance metrics were sensitivity, specificity, positive predictive value, negative predictive value (NPV) and number needed to screen (NNS). Subgroup analysis of patients aged ≥65 years was also performed.ResultsOf 2,542,732 patients in DISCOVER, the algorithm identified 604,135 patients suitable for risk assessment. Of these, 3.0% (17,880 patients) had a diagnosis of atrial fibrillation recorded before study end. The area under the curve of the receiver operating characteristic was 0.87, compared with 0.83 in algorithm development. The NNS was nine patients, matching the CPRD cohort. In patients aged ≥30 years, the algorithm correctly identified 99.1% of patients who did not have atrial fibrillation (NPV) and 75.0% of true atrial fibrillation cases (sensitivity). Among patients aged ≥65 years (n = 117,965), the NPV was 96.7% with 91.8% sensitivity.ConclusionsThis atrial fibrillation risk prediction algorithm, based on machine learning methods, identified patients at highest risk of atrial fibrillation. It performed comparably in a large, real-world population-based cohort and the developmental registry cohort. If implemented in primary care, the algorithm could be an effective tool for narrowing the population who would benefit from atrial fibrillation screening in the United Kingdom.
      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-08-13T07:01:38Z
      DOI: 10.1177/2047487320942338
       
  • Risk of cardiovascular disease for women with polycystic ovary syndrome:
           results from a national Danish registry cohort study

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      Authors: Clare Oliver-Williams, Ditte Vassard, Anja Pinborg, Lone Schmidt
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-08-02T11:05:15Z
      DOI: 10.1177/2047487320939674
       
  • How to manage an athlete with mitral valve prolapse

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      Authors: Elena Cavarretta, Mariangela Peruzzi, Francesco Versaci, Giacomo Frati, Luigi Sciarra
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.
      IntroductionUnder the term degenerative mitral valve prolapse different pathophysiological and clinical entities coexist in a spectrum ranging from Barlow’s disease to fibroelastic deficiency, and represent the most common cause of mitral regurgitation in the general population and in athletes. Carrying a mitral valve prolapse is usually considered a benign condition for athletes, but recently the scientific literature has focused on the malignant, thus rare, arrhythmic mitral valve prolapse and its dramatic association with sudden cardiac death, so that specific features should be considered a red flag and prompt additional exams before clear for competition.DiscussionAs the athlete’s heart is morphologically accompanied by remodelling and dilatation of the cardiac chambers induced by exercise, it may be challenging to differentiate the degree of left ventricular and atrial dilation induced by significant mitral regurgitation from physiological remodelling, especially in endurance athletes.ConclusionThis how-to article provides clinical and useful data to manage athletes with mitral valve prolapse and to distinguish high-risk athletes carrying the features of arrhythmic mitral valve prolapse.
      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-07-31T04:11:44Z
      DOI: 10.1177/2047487320941646
       
  • Electronic cigarettes and health with special focus on cardiovascular
           effects: position paper of the European Association of Preventive
           Cardiology (EAPC)

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      Authors: Maryam Kavousi, Charlotta Pisinger, Jean-Claude Barthelemy, Delphine De Smedt, Konstantinos Koskinas, Pedro Marques-Vidal, Demosthenes Panagiotakos, Eva Bossano Prescott, Monica Tiberi, Vassilios S Vassiliou, Maja-Lisa Løchen
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.
      BackgroundTobacco use is the single largest preventable risk factor for premature death of non-communicable diseases and the second leading cause of cardiovascular disease. In response to the harmful effects of tobacco smoking, the use of electronic cigarettes (e-cigarettes) has emerged and gained significant popularity over the past 15 years. E-cigarettes are promoted as safe alternatives for traditional tobacco smoking and are often suggested as a way to reduce or quit smoking. However, evidence suggests they are not harmless.DiscussionThe rapid evolution of the e-cigarette market has outpaced the legislator’s regulatory capacity, leading to mixed regulations. The increasing use of e-cigarettes in adolescents and young individuals is of concern. While the long-term direct cardiovascular effects of e-cigarettes remain largely unknown, the existing evidence suggests that the e-cigarette should not be regarded as a cardiovascular safe product. The contribution of e-cigarette use to reducing conventional cigarette use and smoking cessation is complex, and the impact of e-cigarette use on long-term cessation lacks sufficient evidence.ConclusionThis position paper describes the evidence regarding the prevalence of e-cigarette smoking, uptake of e-cigarettes in the young, related legislations, cardiovascular effects of e-cigarettes and the impact of e-cigarettes on smoking cessation. Knowledge gaps in the field are also highlighted. The recommendations from the population science and public health section of the European Association of Preventive Cardiology are presented.
      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-07-29T11:06:17Z
      DOI: 10.1177/2047487320941993
       
  • The rise and fall of e-cigarettes according to Aesop: Editorial regarding
           EAPC position paper ‘Electronic cigarettes and health with special focus
           on cardiovascular effects’

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      Authors: Joep Perk
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-07-29T11:05:32Z
      DOI: 10.1177/2047487320938907
       
  • Effects of linagliptin on left ventricular DYsfunction in patients with
           type 2 DiAbetes and concentric left ventricular geometry: results of the
           DYDA 2 trial

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      Authors: Giovanni Cioffi, Carlo Bruno Giorda, Donata Lucci, Elisa Nada, Federica Ognibeni, Costantino Mancusi, Roberto Latini, Aldo P Maggioni
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.
      AimsTo evaluate the effect of linagliptin on left ventricular systolic function beyond glycaemic control in type 2 diabetes mellitus.Methods and resultsA multicentre, randomised, double-blind, placebo controlled, parallel-group study, was performed (the DYDA 2 trial). Individuals with type 2 diabetes mellitus and asymptomatic impaired left ventricular systolic function were randomly allocated in a 1:1 ratio to receive for 48 weeks either linagliptin 5 mg daily or placebo, in addition to their diabetes therapy. Eligibility criteria were age 40 years and older, haemoglobin A1c 8.0% or less (≤64 mmol/mol), no history of cardiac disease, concentric left ventricular geometry (relative wall thickness ≥0.42), impaired left ventricular systolic function defined as midwall fractional shortening 15% or less at baseline echocardiography. The primary end point was the modification of midwall fractional shortening over time. The main secondary objectives were changes in diastolic and/or in longitudinal left ventricular systolic function as measured by tissue Doppler echocardiography. One hundred and eighty-eight patients were enrolled, predominantly men with typical insulin-resistance comorbidities. At baseline, mean midwall fractional shortening was 13.3%±2.5. At final evaluation, 88 linagliptin patients and 86 placebo patients were compared: midwall fractional shortening increased from 13.29 to 13.82 (+4.1%) in the linagliptin group, from 13.58 to 13.84 in the placebo group (+1.8%, analysis of covariance P = 0.86), corresponding to a 2.3-fold higher increase in linagliptin than the placebo group, although non-statistically significant. Also, changes in diastolic and longitudinal left ventricular systolic function did not differ between the groups. Serious adverse events or linagliptin/placebo permanent discontinuation occurred in very few cases and in the same percentage between the groups.ConclusionsIn the DYDA 2 patients the addition of linagliptin to stable diabetes therapy was safe and provided a modest non-significant increase in left ventricular systolic function measured as midwall fractional shortening.Trial registration number: ClinicalTrial.gov (ID NCT02851745)
      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-07-29T04:39:16Z
      DOI: 10.1177/2047487320939217
       
  • Cardiovascular disease in Italy: good news, bad news and interesting news

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      Authors: Pedro Marques-Vidal
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-07-29T04:39:15Z
      DOI: 10.1177/2047487320940474
       
  • Intensity of statin treatment after acute coronary syndrome, residual
           risk, and its modification by alirocumab: insights from the ODYSSEY
           OUTCOMES trial

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      Authors: Rafael Diaz, Qian H Li, Deepak L Bhatt, Vera A Bittner, Marie T Baccara-Dinet, Shaun G Goodman, J Wouter Jukema, Takeshi Kimura, Alexander Parkhomenko, Robert Pordy, Željko Reiner, Matthew T Roe, Michael Szarek, Hung-Fat Tse, Harvey D White, Doron Zahger, Andreas M Zeiher, Gregory G Schwartz, Ph Gabriel Steg
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.
      AimsStatins are pivotal to the secondary prevention of major adverse cardiovascular events, but some patients are statin-intolerant. We examined the effects of the proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor alirocumab on the risk of major adverse cardiovascular events according to the intensity of background statin treatment.Methods and resultsThe ODYSSEY OUTCOMES trial compared alirocumab with placebo in 18,924 patients with acute coronary syndrome and dyslipidaemia despite intensive or maximum-tolerated statin treatment (including no statin if intolerance was documented). The primary outcome (major adverse cardiovascular events) comprised coronary heart disease death, non-fatal myocardial infarction, ischaemic stroke, or unstable angina. Median follow-up was 2.8 years. Baseline statin treatment was high-intensity (88.8%), low/moderate-intensity (8.7%) or none (2.4%). Median baseline low-density lipoprotein cholesterol was 86, 89 and 139 mg/dL (P 
      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-07-28T06:02:29Z
      DOI: 10.1177/2047487320941987
       
  • Structural heart disease, cardiac dysfunction and heart failure: the
           ambiguity of a definition

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      Authors: Pierpaolo Pellicori, John GF Cleland
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-07-28T06:02:28Z
      DOI: 10.1177/2047487320937135
       
  • Physical exercise training in patients with a Fontan circulation: A
           systematic review

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      Authors: Linda E Scheffers, Linda EM vd Berg, Gamida Ismailova, Karolijn Dulfer, Johanna JM Takkenberg, Wim A Helbing
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.
      BackgroundPatients with a Fontan circulation have a reduced exercise capacity, which is an important prognostic predictor of morbidity and mortality. A way to increase exercise capacity in Fontan patients might be exercise training. This systematic review assesses the effects of exercise training investigated in Fontan patients in order to provide an overview of current insights.Design and methodsStudies evaluating an exercise training intervention in Fontan patients published up to February 2020 were included in this systematic review.ResultsFrom 3000 potential studies, 16 studies reported in 22 publications met the inclusion criteria. In total, 264 Fontan patients with mean age range 8.7–31 years, were included. Different training types including inspiratory muscle training, resistance training and aerobic training were investigated. Main outcome measures reported were peak oxygen uptake, cardiac function, lung function, physical activity levels and quality of life. Peak oxygen uptake increased significantly in 56% of the studies after training with an overall mean increase of +1.72 ml/kg/min (+6.3%). None of the studies reported negative outcome measures related to the exercise programme. In four studies an adverse event was reported, most likely unrelated to the training intervention.ConclusionsExercise training in Fontan patients is most likely safe and has positive effects on exercise capacity, cardiac function and quality of life. Therefore exercise training in Fontan patients should be encouraged. Further studies are required to assess the optimal training type, intensity, duration and long-term effects.
      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-07-28T06:02:27Z
      DOI: 10.1177/2047487320942869
       
  • Life-threatening and major cardiac events during long-distance races:
           updates from the prospective RACE PARIS registry with a systematic review
           and meta-analysis

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      Authors: Benoît Gerardin, Paul Guedeney, Anne Bellemain-Appaix, Thomas Levasseur, Hazrije Mustafic, Hakim Benamer, Jacques Monsegu, Lionel Lamhaut, Gilles Montalescot, Pierre Aubry, Jean-Philippe Collet
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.
      AimsLimited data exist regarding the incidence and aetiology of life-threatening events such as major cardiac events or exertional heat stroke during long-distance races. We aimed to provide an updated incidence, etiology and prognosis of life-threatening events during long-distance races.MethodsThe prospective RACE PARIS registry recorded all life-threatening events/fatal events occurring during 46 marathons, half-marathons and other long-distance races in the Paris area between 2006 and 2016, comprising 1,073,722 runners. Event characteristics were determined by review of medical records and interviews with survivors.ResultsThe incidence of life-threatening events, exertional heat stroke and major cardiac events was 3.35 per 100,000, 1.02 per 100,000 and 2.33 per 100,000, respectively, including 18 sudden cardiac arrests (1.67 per 100,000). The main aetiology of sudden cardiac arrest was myocardial ischaemia (11/18), due to acute coronary thrombosis (6/11), stable atherosclerotic coronary artery disease (2/11), coronary dissection (1/11), anomalous connection (1/11) or myocardial bridging (1/11). A third of participants with ischaemia-related major cardiac events presented with pre-race clinical symptoms. Major cardiac events were more frequent in the case of a high pollution index (6.78 per 100,000 vs. 2.07 per 100,000, odds ratio 3.27, 95% confidence interval 1.12–9.54). Case fatality was low (0.19 per 100,000). Similarly, we report in a meta-analysis of eight long-distance race registries comprising 16,223,866 runners a low incidence of long-distance race-related sudden cardiac arrest (0.82 per 100,000) and fatality (0.39 per 100,000). Death following sudden cardiac arrest was strongly associated with initial asystole or pulseless rhythm.ConclusionLong-distance race-related life-threatening events remain rare although serious events. Better information for runners on the risk of pre-race clinical symptoms, outside air pollution and temperature may reduce their incidence.
      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-07-28T06:02:26Z
      DOI: 10.1177/2047487320943001
       
  • Next-generation sequencing to confirm clinical familial
           hypercholesterolemia

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      Authors: Laurens F Reeskamp, Tycho R Tromp, Joep C Defesche, Aldo Grefhorst, Erik SG Stroes, G Kees Hovingh, Linda Zuurbier
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.
      BackgroundFamilial hypercholesterolemia is characterised by high low-density lipoprotein-cholesterol levels and is caused by a pathogenic variant in LDLR, APOB or PCSK9. We investigated which proportion of suspected familial hypercholesterolemia patients was genetically confirmed, and whether this has changed over the past 20 years in The Netherlands.MethodsTargeted next-generation sequencing of 27 genes involved in lipid metabolism was performed in patients with low-density lipoprotein-cholesterol levels greater than 5 mmol/L who were referred to our centre between May 2016 and July 2018. The proportion of patients carrying likely pathogenic or pathogenic variants in LDLR, APOB or PCSK9, or the minor familial hypercholesterolemia genes LDLRAP1, ABCG5, ABCG8, LIPA and APOE were investigated. This was compared with the yield of Sanger sequencing between 1999 and 2016.ResultsA total of 227 out of the 1528 referred patients (14.9%) were heterozygous carriers of a pathogenic variant in LDLR (80.2%), APOB (14.5%) or PCSK9 (5.3%). More than 50% of patients with a Dutch Lipid Clinic Network score of ‘probable’ or ‘definite’ familial hypercholesterolemia were familial hypercholesterolemia mutation-positive; 4.8% of the familial hypercholesterolemia mutation-negative patients carried a variant in one of the minor familial hypercholesterolemia genes. The mutation detection rate has decreased over the past two decades, especially in younger patients in which it dropped from 45% in 1999 to 30% in 2018.ConclusionsA rare pathogenic variant in LDLR, APOB or PCSK9 was identified in 14.9% of suspected familial hypercholesterolemia patients and this rate has decreased in the past two decades. Stringent use of clinical criteria algorithms is warranted to increase this yield. Variants in the minor familial hypercholesterolemia genes provide a possible explanation for the familial hypercholesterolemia phenotype in a minority of patients.
      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-07-28T06:02:25Z
      DOI: 10.1177/2047487320942996
       
  • Assessing cardiovascular risk in cancer patients: opportunities and
           challenges

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      Authors: Avirup Guha, Nihar R Desai, Neal L Weintraub
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-07-28T06:02:25Z
      DOI: 10.1177/2047487320943002
       
  • Unexplained sudden cardiac arrest in children: clinical and genetic
           characteristics of survivors

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      Authors: Emanuele Monda, Berardo Sarubbi, Maria Giovanna Russo, Martina Caiazza, Cristina Mazzaccara, Jessica Magrelli, Marta Rubino, Augusto Esposito, Alessia Perna, Annalisa Passariello, Eduardo Bossone, Emanuele Romeo, Diego Colonna, Maria Valeria Esposito, Valeria D’Argenio, Francesco Salvatore, Giuseppe Pacileo, Lia Crotti, Giulia Frisso, Giuseppe Limongelli
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-07-27T05:39:52Z
      DOI: 10.1177/2047487320940863
       
  • Association between chocolate consumption and risk of coronary artery
           disease: a systematic review and meta-analysis

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      Authors: Chayakrit Krittanawong, Bharat Narasimhan, Zhen Wang, Joshua Hahn, Hafeez Ul Hassan Virk, Ann M Farrell, HongJu Zhang, WH Wilson Tang
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-07-22T11:07:20Z
      DOI: 10.1177/2047487320936787
       
  • Sodium glucose cotransporter 2 inhibitors for all HFrEF patients: can we
           afford it' A cost-effectiveness analysis of dapagliflozin

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      Authors: Marcus Dörr
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-07-22T04:31:16Z
      DOI: 10.1177/2047487320940103
       
  • Insomnia is associated with metabolic syndrome in a middle-aged
           population: the SCAPIS pilot cohort

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      Authors: Ding Zou, Heini Wennman, Jan Hedner, Örjan Ekblom, Olof Drotz, Daniel Arvidsson, Göran Bergström, Ludger Grote, Mats Börjesson
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-07-21T04:39:40Z
      DOI: 10.1177/2047487320940862
       
  • A cost-utility analysis of increasing percutaneous coronary intervention
           use in elderly patients with acute coronary syndromes in six European
           countries

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      Authors: C Forné, I Subirana, J Blanch, J Ferrieres, A Azevedo, C Meisinger, D Farmakis, L Tavazzi, M Davoli, R Ramos, M Brosa, J Marrugat, IR Dégano
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.
      AimsPercutaneous coronary intervention reduces mortality in acute coronary syndrome patients but the cost-utility of increasing its use in elderly acute coronary syndrome patients is unknown.MethodsWe assessed the efficiency of increased percutaneous coronary intervention use compared to current practice in patients aged ≥75 years admitted for acute coronary syndrome in France, Germany, Greece, Italy, Portugal and Spain with a semi-Markov state transition model. In-hospital mortality reduction estimates by percutaneous coronary intervention use and costs were derived from the EUROpean Treatment & Reduction of Acute Coronary Syndromes cost analysis EU project (n = 28,600). Risk of recurrence and out-of-hospital all-cause mortality were obtained from the Information System for the Development of Research in Primary Care (SIDIAP) database from North-Eastern Spain (n = 55,564). In-hospital mortality was modelled using stratified propensity score analysis. The 8-year acute coronary syndrome recurrence risk and out-of-hospital mortality were estimated with a multistate survival model. The scenarios analysed were to increase percutaneous coronary intervention use among patients with the highest, moderate and lowest probability of receiving percutaneous coronary intervention based on the propensity score analysis.ResultsFrance, Greece and Portugal showed similar total costs/1000 individuals (7.29–11.05 m €); while in Germany, Italy and Spain, costs were higher (13.53–22.57 m €). Incremental cost-utility ratios of providing percutaneous coronary intervention to all patients ranged from 2262.8 €/quality adjusted life year gained for German males to 6324.3 €/quality adjusted life year gained for Italian females. Increasing percutaneous coronary intervention use was cost-effective at a willingness-to-pay threshold of 10,000 €/quality adjusted life year gained for all scenarios in the six countries, in males and females.ConclusionCompared to current clinical practice, broadening percutaneous coronary intervention use in elderly acute coronary syndrome patients would be cost-effective across different healthcare systems in Europe, regardless of the selected strategy.
      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-07-21T04:39:40Z
      DOI: 10.1177/2047487320942644
       
  • Eligibility for PCSK9 inhibitors based on the 2019 ESC/EAS and 2018
           ACC/AHA guidelines

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      Authors: Konstantinos C Koskinas, Baris Gencer, David Nanchen, Mattia Branca, David Carballo, Roland Klingenberg, Manuel R Blum, Sebastian Carballo, Olivier Muller, Christian M Matter, Thomas F Lüscher, Nicolas Rodondi, Dik Heg, Matthias Wilhelm, Lorenz Räber, François Mach, Stephan Windecker
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.
      AimsThe 2018 American College of Cardiology (ACC)/American Heart Association (AHA) and 2019 European Society of Cardiology (ESC)/European Atherosclerosis Society (EAS) lipid guidelines recently updated their recommendations regarding proprotein convertase subtilisin/kexin-9 inhibitors (PCSK9i). We assessed the potential eligibility for PCSK9i according to the new guidelines in patients with acute coronary syndromes.Methods and resultsWe analysed a contemporary, prospective Swiss cohort of patients hospitalised for acute coronary syndromes. We modelled a statin intensification effect and an incremental ezetimibe effect on low-density lipoprotein-cholesterol levels among patients who were not on high-intensity statins or ezetimibe. One year after the index acute coronary syndrome event, treatment eligibility for PCSK9i was defined as low-density lipoprotein-cholesterol of 1.4 mmol/l or greater according to ESC/EAS guidelines. For ACC/AHA guidelines, treatment eligibility was defined as low-density lipoprotein-cholesterol of 1.8 mmol/l or greater in the presence of very high-risk atherosclerotic cardiovascular disease, defined by multiple major atherosclerotic cardiovascular disease events and/or high-risk conditions. Of 2521 patients, 93.2% were treated with statins (53% high-intensity statins) and 7.3% with ezetimibe at 1 year, and 54.9% had very high-risk atherosclerotic cardiovascular disease. Low-density lipoprotein-cholesterol levels less than 1.8 mmol/l and less than 1.4 mmol/l at 1 year were observed in 37.5% and 15.7% of patients, respectively. After modelling the statin intensification and ezetimibe effects, these numbers increased to 76.1% and 49%, respectively. The proportion of patients eligible for PCSK9i was 51% according to ESC/EAS criteria versus 14% according to ACC/AHA criteria.ConclusionsIn this analysis, the 2019 ESC/EAS guidelines rendered half of all post-acute coronary syndrome patients potentially eligible for PCSK9i treatment, as compared to a three-fold lower eligibility rate based on the 2018 ACC/AHA guidelines.
      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-07-21T04:39:39Z
      DOI: 10.1177/2047487320940102
       
  • First experience with video-guided home-based exercise training for
           patients with stable coronary artery disease after elective percutaneous
           coronary interventions

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      Authors: Valentina Martynova, Denis Andreev, Ilya Giverts, Alexey Svet, Abram Syrkin, Hugo Saner
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-07-21T04:39:39Z
      DOI: 10.1177/2047487320940106
       
  • Cardiorespiratory fitness and survival following cancer diagnosis

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      Authors: Alexander Fardman, Gabriel D Banschick, Razi Rabia, Ruth Percik, Dana Fourey, Shlomo Segev, Robert Klempfner, Ehud Grossman, Elad Maor
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.
      AimsData on the association of cardiorespiratory fitness with survival of cancer patients are limited. This study aimed to evaluate the association between midlife cardiorespiratory fitness and survival after a subsequent cancer diagnosis.MethodsWe evaluated 19,134 asymptomatic self-referred adults who were screened in preventive healthcare settings. All subjects were free of cardiovascular disease and cancer at baseline and completed a maximal exercise stress test. Fitness was categorised into age-specific and sex-specific quintiles according to the treadmill time and dichotomised to low (quintiles 1–2) and high fitness groups.ResultsThe mean age was 50 ± 8 years and 72% were men. During a median follow-up of 13 years (interquartile range 7–16) 517 (3%) died. Overall, 1455 (7.6%) subjects developed cancer with a median time to cancer diagnosis of 6.4 years (interquartile range 3–10). Death from the time of cancer diagnosis was significantly lower among the high fitness group (Plog rank = 0.03). Time-dependent analysis showed that subjects who developed cancer during follow-up were more likely to die (P 
      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-07-20T05:50:28Z
      DOI: 10.1177/2047487320930873
       
  • Aortic calcification; from innocent bystander to independent predictor;
           the delicate balance in biology; da Capo: Editorial accompanying
           ‘Abdominal aortic calcification – from ancient friend to modern foe’
           

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      Authors: Alf Inge Larsen
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-07-17T06:04:49Z
      DOI: 10.1177/2047487320937130
       
  • Editorial: Ideal cardiovascular health and sudden cardiac death

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      Authors: Yuling Zhang
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-07-15T05:09:50Z
      DOI: 10.1177/2047487320913710
       
  • Cost-effectiveness of dapagliflozin in chronic heart failure: an analysis
           from the Australian healthcare perspective

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      Authors: Feby Savira, Bing H Wang, Andrew R Kompa, Zanfina Ademi, Alice J Owen, Sophia Zoungas, Andrew Tonkin, Danny Liew, Ella Zomer
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.
      AimTo assess the cost-effectiveness of dapagliflozin in addition to standard care versus standard care alone in patients with chronic heart failure and reduced ejection fraction.MethodsA Markov model was constructed based on the Dapagliflozin and Prevention of Adverse Outcomes in Heart Failure trial to assess the clinical outcomes and costs of 1000 hypothetical subjects with established heart failure and reduced ejection fraction. The model consisted of three health states: ‘alive and event-free’, ‘alive after non-fatal hospitalisation for heart failure’ and ‘dead’. Costs and utilities were estimated from published sources. The main outcome was the incremental cost-effectiveness ratio per quality-adjusted life-year gained. An Australian public healthcare perspective was employed. All outcomes and costs were discounted at a rate of 5% annually.ResultsOver a lifetime horizon, the addition of dapagliflozin to standard care in patients with heart failure and reduced ejection fraction prevented 88 acute heart failure hospitalisations (including readmissions) and yielded an additional 416 years of life and 288 quality-adjusted life-years (discounted) at an additional cost of A$3,692,440 (discounted). This equated to an incremental cost-effectiveness ratio of A$12,482 per quality-adjusted life-year gained, well below the Australian willingness-to-pay threshold of A$50,000 per quality-adjusted life-year gained. Subanalyses in subjects with and without diabetes resulted in similar incremental cost-effectiveness ratios of A$13,234 and A$12,386 per quality-adjusted life-year gained, respectively.ConclusionDapagliflozin is likely to be cost-effective when used as an adjunct therapy to standard care compared with standard care alone for the treatment of chronic heart failure and reduced ejection fraction.
      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-07-15T05:09:50Z
      DOI: 10.1177/2047487320938272
       
  • Non-adherence to established dietary guidelines associated with increased
           mortality: the Copenhagen General Population Study

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      Authors: Bettina Ewers, Jacob L Marott, Peter Schnohr, Børge G Nordestgaard, Peter Marckmann
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.
      AimsThe relevance of adherence to established dietary guidelines is repeatedly challenged. We hypothesised that non-adherence to established dietary guidelines is associated with an excess risk of cardiovascular, non-cardiovascular and all-cause mortality.MethodsWe studied 100,191 white adult Danes aged 20–100 years recruited in 2003–2015 and followed up until December 2018. During follow-up equalling 865,600 person-years, 9273 individuals died. Participants’ diets were assessed at baseline by a food frequency questionnaire focusing on key foods defining a healthy diet according to Danish dietary guidelines. Individuals were divided into five categories ranging from very high to very low adherence to dietary guidelines and studied with Cox and Fine–Gray regression models. At study inclusion, we collected demographic and lifestyle characteristics by questionnaire, made a physical examination and took a blood sample.ResultsCardiovascular, non-cardiovascular and all-cause mortality increased gradually with increasing non-adherence to dietary guidelines. Cardiovascular mortality was 30% higher (95% confidence interval 7–57%), non-cardiovascular mortality 54% higher (32–79%) and all-cause mortality 43% higher (29–59%) in individuals with very low adherence to dietary guidelines compared with those with very high adherence after adjustments for age, sex, education, income, smoking, leisure time physical activity and alcohol intake. Mortality risk estimates were similar in all strata of adjusted variables.ConclusionNon-adherence to Danish food-based dietary guidelines is associated with up to 43% increased all-cause mortality in a dose–response manner. The mortality excess was seen for both cardiovascular and non-cardiovascular causes. The public has good reasons to have confidence in and to adhere to established dietary guidelines.
      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-07-10T05:08:47Z
      DOI: 10.1177/2047487320937491
       
  • Beyond randomised studies: recommendations for cardiac rehabilitation
           following repair of thoracic aortic aneurysm or dissection

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      Authors: Bernhard Schwaab, Bernhard Rauch, Heinz Völler, Werner Benzer, Jean-Paul Schmid
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-07-10T05:08:46Z
      DOI: 10.1177/2047487320936782
       
  • The impact of air pollution and weather on cardiovascular events: The
           importance of time scale and historical air quality improvement

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      Authors: Bart De Geest, Mudit Mishra
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-07-09T05:39:35Z
      DOI: 10.1177/2047487320938268
       
  • Antihypertensive strategies and hypertension control in Sub-Saharan Africa

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      Authors: Pauline Cavagna, Méo Stéphane IIkama, Kouadio Euloge Kramoh, Jean Laurent Takombe, Ibrahima Bara Diop, Ibrahim Ali Toure, Dadhi M Balde, Anastase Dzudie, Beatriz Ferreira, Martin D Houenassi, Murielle Hounkponou, Adama Kane, Suzy G Kimbally-Kaki, Samuel Kingue, Charles Kouam Kouam, Emmanuel Limbole, Liliane Mfeukeu Kuate, Jean Bruno Mipinda, Roland N’guetta, Carol Nhavoto, Jean Marie Damorou, Abdallahi Sidy Ali, Bamba Gaye, Gabriel S Tajeu, Diane Macquart de Terline, Marie Cécile Perier, Michel Azizi, Xavier Jouven, Marie Antignac
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-07-08T05:28:11Z
      DOI: 10.1177/2047487320937492
       
  • The morbidity and mortality of COVID-19 are associated with ABO and Rh
           blood groups

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      Authors: Maryam Ansari-Lari, Mostafa Saadat
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-07-08T04:55:38Z
      DOI: 10.1177/2047487320939216
       
  • Obesity, overweight and survival in critically ill patients with
           SARS-CoV-2 pneumonia: is there an obesity paradox' Preliminary results
           from Italy

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      Authors: Geza Halasz, Matteo LG Leoni, Giovanni Quinto Villani, Massimo Nolli, Matteo Villani
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-07-08T04:55:38Z
      DOI: 10.1177/2047487320939675
       
  • Predictive ability of longitudinal changes in PRECISE-DAPT score in
           patients on dual antiplatelet therapy: The RE-SCORE multicentre
           prospective registry

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      Authors: Francesco Pelliccia, Vincenzo Pasceri, Giuseppe Marazzi, Luca Cacciotti, Attilio Placanica, Felice Gragnano, Giampaolo Niccoli, Tullio Palmerini, Gaetano Tanzilli, Giulio Speciale, Antonino Granatelli, Paolo Calabrò, Filippo Crea, Carlo Gaudio
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-07-06T03:55:54Z
      DOI: 10.1177/2047487320937846
       
  • Use of lipoprotein(a) for refining cardiovascular risk prediction in a
           low-risk population: The CoLaus/PsyCoLaus study

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      Authors: Benoît Delabays, Pedro Marques-Vidal, Florian Kronenberg, Gérard Waeber, Peter Vollenweider, Julien Vaucher
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-07-06T03:55:54Z
      DOI: 10.1177/2047487320938271
       
  • The future is now: a call for action for cardiac telerehabilitation in the
           COVID-19 pandemic from the secondary prevention and rehabilitation section
           of the European Association of Preventive Cardiology

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      Authors: Martijn Scherrenberg, Matthias Wilhelm, Dominique Hansen, Heinz Völler, Véronique Cornelissen, Ines Frederix, Hareld Kemps, Paul Dendale
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.
      The role of comprehensive cardiac rehabilitation is well established in the secondary prevention of cardiovascular diseases such as coronary artery disease and heart failure. Numerous trials have demonstrated both the effectiveness as well as the cost-effectiveness of comprehensive cardiac rehabilitation in improving exercise capacity and quality of life, and in reducing cardiovascular mortality and morbidity. However, the current COVID-19 pandemic has led to closure of many cardiac rehabilitation centres in Europe resulting in many eligible patients unable to participate in the optimisation of secondary prevention and physical performance. This elicits an even louder call for alternatives such as cardiac telerehabilitation to maintain the delivery of the core components of cardiac rehabilitation to cardiovascular disease patients. The present call for action paper gives an update of recent cardiac telerehabilitation studies and provides a practical guide for the setup of a comprehensive cardiac telerehabilitation intervention during the COVID-19 pandemic. This set up could also be relevant to any cardiovascular disease patient not able to visit cardiac rehabilitation centres regularly after the COVID-19 pandemic ceases.
      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-07-03T06:22:25Z
      DOI: 10.1177/2047487320939671
       
  • Yield and clinical significance of genetic screening in elite and amateur
           athletes

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      Authors: Giuseppe Limongelli, Marcella Nunziato, Valeria D'Argenio, Maria V Esposito, Emanuele Monda, Cristina Mazzaccara, Martina Caiazza, Antonello D’Aponte, Antonello D’Andrea, Eduardo Bossone, Federica Di Maggio, Pasqualina Buono, Paolo W Pica, Luca De Capua, Maria Penco, Silvio Romano, Fernando Di Paolo, Antonio Pelliccia, Giulia Frisso, Francesco Salvatore
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.
      AimsThe purpose of this study was to assess the value of genetic testing in addition to a comprehensive clinical evaluation, as part of the diagnostic work-up of elite and/or amateur Italian athletes referred for suspicion of inherited cardiac disease, following a pre-participation screening programme.MethodsBetween January 2009–December 2018, of 5892 consecutive participants, 61 athletes were investigated: 30 elite and 31 amateur athletes. Elite and amateur athletes were selected, on the basis of clinical suspicion for inherited cardiac disease, from two experienced centres for a comprehensive cardiovascular evaluation. Furthermore, the elite and amateur athletes were investigated for variants at DNA level up to 138 genes suspected to bear predisposition for possible cardiac arrest or even sudden cardiac death.ResultsOf these 61 selected subjects, six (10%) had diagnosis made possible by a deeper clinical evaluation, while genetic testing allowed a definite diagnosis in eight (13%). The presence of>3 clinical markers (i.e. family history, electrocardiogram and/or echocardiographic abnormalities, exercise-induced ventricular arrhythmias) was associated with a higher probability of positive genetic diagnosis (75%), compared with the presence of two or one clinical markers (14.2%, 8.1%, respectively, p-value = 0.004).ConclusionA combined clinical and genetic evaluation, based on the subtle evidence of clinical markers for inherited disease, was able to identify an inherited cardiac disease in about one-quarter of the examined athletes.
      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-07-03T05:30:48Z
      DOI: 10.1177/2047487320934265
       
  • Candidate genes in coronary syndromes: seeing the bigger picture

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      Authors: Marcus Sandri, Katharina Kirsch, Sandra Erbs, Holger Thiele
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-07-02T05:10:33Z
      DOI: 10.1177/2047487320934262
       
  • Association of remote ischaemic conditioning with cardiovascular events
           and death in STEMI patients: a meta-analysis of randomised clinical trials
           

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      Authors: Ruifeng Guo, Xiao Wang, Wen Hao, Wei Gong, Shaoping Nie
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-07-02T05:10:33Z
      DOI: 10.1177/2047487320934666
       
  • The effects of transitions in metabolic health and obesity status on
           incident cardiovascular disease: Insights from a general Chinese
           population

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      Authors: Xiaofan Guo, Zhao Li, Ying Zhou, Shasha Yu, Hongmei Yang, Guozhe Sun, Liqiang Zheng, Junaid Afzal, Yamin Liu, Yingxian Sun
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.
      BackgroundRecent studies have investigated the association of transitions in metabolic health and obesity status over time with the risk of cardiovascular disease, focusing on the subgroup demonstrating metabolically healthy obesity. However, these studies have produced inconsistent results. This study evaluates the relation in a general Chinese population.MethodsWe conducted a prospective cohort study in a general population in Northeast China, with examinations of cardiovascular health from 2012–2015 and follow-up for incident cardiovascular disease until 2018. Cox proportional hazards and logistic regression models were used to investigate the association of baseline metabolic health and obesity status and transitions in those statuses with cardiovascular disease risk.ResultsA total of 7472 participants aged ≥35 years who were free of cardiovascular disease at baseline were included in this analysis. Over a median follow-up of 4.66 years, a total of 344 cardiovascular disease events occurred. Among the 3380 participants who were obese at baseline, 37.1% were metabolically healthy. Metabolically healthy obesity was associated with a 48% increased risk of cardiovascular disease (hazard ratio: 1.48; 95% confidence interval: 1.07–2.06) compared with the metabolically healthy non-obese group at baseline. Transition from metabolically healthy obesity to metabolically unhealthy obesity was associated with elevated cardiovascular disease risk with an odds ratio of 1.82 (95% confidence interval: 1.06–3.14) compared with metabolically healthy non-obesity throughout after adjustment. Even maintaining metabolically healthy obesity over time was associated with a higher risk of cardiovascular disease (odds ratio: 1.72; 95% confidence interval: 1.00–2.97).ConclusionsWeight control and management of existing metabolic disorders should be prioritized in all obese population.
      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-07-02T05:10:31Z
      DOI: 10.1177/2047487320935550
       
  • Τhe European and American guidelines in the detection of hypertension
           phenotypes: The no-deal under the light of clinical practice

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      Authors: Christina Antza, Ioannis Doundoulakis, Georgios Kostopoulos, Stella Stabouli, Vasilios Kotsis
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-07-02T05:10:31Z
      DOI: 10.1177/2047487320935559
       
  • Morphology of premature ventricular complexes: Time for a paradigm shift
           in the approach of ventricular ectopy in athletes'

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      Authors: Alexandros Kasiakogias, Michael Papadakis
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-07-02T05:10:30Z
      DOI: 10.1177/2047487320937493
       
  • Phenotypic predictors of aortic root dilation in essential hypertension

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      Authors: Ruan Kruger
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-07-02T05:10:29Z
      DOI: 10.1177/2047487320934259
       
  • Exercise prescription in cardiac rehabilitation needs to be more accurate

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      Authors: Wei-guang Li, Zheng Huang, Xin-an Zhang
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-07-01T05:07:45Z
      DOI: 10.1177/2047487320936021
       
  • Temporal trends and predictors of inhospital death in patients
           hospitalised for heart failure in Germany

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      Authors: Karsten Keller, Lukas Hobohm, Mir A Ostad, Sebastian Göbel, Mareike Lankeit, Stavros Konstantinides, Thomas Münzel, Philip Wenzel
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.
      AimsWe investigated trends in incidence, case fatality rate, patient characteristics and adverse inhospital events of patients hospitalised for heart failure in Germany.Methods and resultsThe German nationwide inpatient sample (2005–2016) was used for this analysis. Patients hospitalised due to heart failure were selected for analysis. Temporal trends in the incidence of hospitalisations, case fatality rate and treatments were analysed and predictors of inhospital death were identified. The analysis comprised a total number of 4,539,140 hospitalisations (52.0% women, 81.0% aged ≥70 years) due to heart failure. Although hospitalisations increased from 381 (2005) to 539 per 100,000 population (2016) (β estimate 0.06, 95% confidence interval (CI) 0.06 to 0.07, P 
      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-07-01T05:07:44Z
      DOI: 10.1177/2047487320936020
       
  • Recommendations for participation in leisure-time physical activity and
           competitive sports in patients with arrhythmias and potentially
           arrhythmogenic conditions: Part 1: Supraventricular arrhythmias. A
           position statement of the Section of Sports Cardiology and Exercise from
           the European Association of Preventive Cardiology (EAPC) and the European
           Heart Rhythm Association (EHRA), both associations of the European Society
           of Cardiology

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      Authors: Hein Heidbuchel, Paolo E Adami, Matthias Antz, Frieder Braunschweig, Pietro Delise, Daniel Scherr, Erik E Solberg, Matthias Wilhelm, Antonio Pelliccia
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.
      Symptoms attributable to arrhythmias are frequently encountered in clinical practice. Cardiologists and sport physicians are required to identify high-risk individuals harbouring such conditions and provide appropriate advice regarding participation in regular exercise programmes and competitive sport. The three aspects that need to be considered are: (a) the risk of life-threatening arrhythmias by participating in sports; (b) control of symptoms due to arrhythmias that are not life-threatening but may hamper performance and/or reduce the quality of life; and (c) the impact of sports on the natural progression of the underlying arrhythmogenic condition. In many cases, there is no unequivocal answer to each aspect and therefore an open discussion with the athlete is necessary, in order to reach a balanced decision. In 2006 the Sports Cardiology and Exercise Section of the European Association of Preventive Cardiology published recommendations for participation in leisure-time physical activity and competitive sport in individuals with arrhythmias and potentially arrhythmogenic conditions. More than a decade on, these recommendations are partly obsolete given the evolving knowledge of the diagnosis, management and treatment of these conditions. The present document presents a combined effort by the Sports Cardiology and Exercise Section of the European Association of Preventive Cardiology and the European Heart Rhythm Association to offer a comprehensive overview of the most updated recommendations for practising cardiologists and sport physicians managing athletes with supraventricular arrhythmias, and provides pragmatic advice for safe participation in recreational physical activities, as well as competitive sport at amateur and professional level. A companion text on recommendations in athletes with ventricular arrhythmias, inherited arrhythmogenic conditions, pacemakers and implantable defibrillators is published as Part 2 in Europace.
      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-06-29T10:12:36Z
      DOI: 10.1177/2047487320925635
       
  • Overweight and obesity: time to reconsider their role in heart failure

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      Authors: Christos A Papanastasiou, George Giannakoulas
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-06-26T09:10:23Z
      DOI: 10.1177/2047487320933738
       
  • Role of cardiorespiratory fitness in cancer development: time for an
           update

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      Authors: Maxime Boidin, Gregory YH Lip, Dick Thijssen
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-06-26T09:10:22Z
      DOI: 10.1177/2047487320935228
       
  • Not only the status of body weight and metabolic health matters for
           cardiovascular events, but also the temporal changes

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      Authors: Georgios A Christou
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-06-26T09:10:22Z
      DOI: 10.1177/2047487320937489
       
  • Are heart failure observational studies still useful' ‘No need
           to argue’*

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      Authors: Andrea Salzano, Toru Suzuki, Iain B Squire, Antonio Cittadini
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-06-25T05:39:55Z
      DOI: 10.1177/2047487320932258
       
  • Echocardiography in the pre-participation evaluation of asymptomatic
           athletes: the never-ending story

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      Authors: Øyunn Kleiven, Thor Edvardsen, Stein Ørn
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-06-25T05:39:55Z
      DOI: 10.1177/2047487320932269
       
  • Efficacy and safety of bempedoic acid in patients with
           hypercholesterolemia: A systematic review and meta-analysis of randomized
           controlled trials

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      Authors: Lei Dai, Yuyue Zuo, Qiqi You, Hesong Zeng, Shiyi Cao
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.
      AimBempedoic acid is a novel oral drug, which has been increasingly researched to play an important role in the treatment of hypercholesterolemia recently. However, results from original studies were inconsistent and inconclusive. We aimed to conduct a meta-analysis to quantitatively appraise the efficacy and safety of bempedoic acid.MethodsPubMed, Embase, Web of Science and Scopus were searched from inception to 30 January 2020. We included randomized controlled trials that compared the efficacy and safety of bempedoic acid with placebo in patients with hypercholesterolemia. Results from trials were presented as mean differences or odds ratios (ORs) with 95% confidence intervals (CIs) and were pooled by random or fixed effects model. The risk of bias and heterogeneity among trials were also assessed and analyzed.ResultsPooled analysis of 10 eligible trials showed that bempedoic acid treatment resulted in greater lowering of the low-density lipoprotein cholesterol level than the placebo group (mean difference –23.16%, 95% CI –26.92% to –19.04%). We also found that improvements in lipid parameters and biomarkers were still maintained at weeks 24 and 52 from the long-term trials. As for safety, bempedoic acid did not increase the risk of overall adverse events (OR 1.02, 95% CI 0.88 to 1.18). However, the incidence of adverse events leading to discontinuation was higher in the bempedoic acid group (OR 1.44, 95% CI 1.14 to 1.82).ConclusionsAvailable evidence from randomized controlled trials suggests that bempedoic acid provides a well-tolerated and effective therapeutic option for lipid lowering in patients with hyperlipidemia
      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-06-17T11:15:05Z
      DOI: 10.1177/2047487320930585
       
  • Screening for coronary artery calcium in a high-risk population: the
           ROBINSCA trial

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      Authors: Sabine JAM Denissen, Carlijn M van der Aalst, Marleen Vonder, Jan Willem C Gratama, Henk J Adriaansen, Dirkjan Kuijpers, Jeanine E Roeters van Lennep, Rozemarijn Vliegenthart, Pim van der Harst, Richard L Braam, Paul RM van Dijkman, Matthijs Oudkerk, Harry J de Koning
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-06-17T11:15:05Z
      DOI: 10.1177/2047487320932263
       
  • Prescribing, dosing and titrating exercise in patients with hypertrophic
           cardiomyopathy for prevention of comorbidities: Ready for prime time

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      Authors: Luna Cavigli, Iacopo Olivotto, Francesco Fattirolli, Nicola Mochi, Silvia Favilli, Sergio Mondillo, Marco Bonifazi, Flavio D’Ascenzi
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.
      The benefits of physical activity are well established, leading to both cardiovascular and non-cardiovascular benefits, improving quality of life and reducing mortality. Despite such striking body of evidence, patients with hypertrophic cardiomyopathy are often discouraged by health professionals to practice physical activity and personalised exercise prescription is an exception rather than the rule. As a result, hypertrophic cardiomyopathy patients are on average less active and spend significantly less time at work or recreational physical activity than the general population. Exercise restriction derives from the evidence that vigorous exercise may occasionally trigger life-threatening arrhythmias and sudden cardiac death. However, while participation in competitive sports should be prudentially denied, hypertrophic cardiomyopathy patients can benefit from the positive effects of regular physical activity, aimed to reduce the risk of comorbidities and improve the quality of life. Based on this rationale, exercise should be prescribed and titrated just like a drug in hypertrophic cardiomyopathy patients, considering individual characteristics, symptoms, past medical history, objective individual response to exercise, previous training experience and stage of disease. Type, frequency, duration, and intensity should be defined on a personal basis. Yet exercise prescription in hypertrophic cardiomyopathy and its long-term effects represent major gaps in our current knowledge and require extensive research. We here review existing evidence regarding benefits and hazards of physical activity, with specific focus on viable modalities for tailored and safe exercise prescription in these patients, highlighting future developments and relevant research targets.
      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-06-17T11:15:04Z
      DOI: 10.1177/2047487320928654
       
  • Exaggerated blood pressure reaction to exercise in subjects with and
           without systemic hypertension

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      Authors: Cesare de Gregorio, Francesco Giallauria, Giuseppe Lantone, Francesca Bellomo, Mariapaola Campisi, Giorgio Firetto, Paolo Mazzone, Crescenzo Testa, Patrizia Grimaldi, Matteo Casale, Iacopo Ciccarelli, Filippo Maria Sarullo, Angela Alibrandi, Alessandro Migliorato
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-06-17T11:15:03Z
      DOI: 10.1177/2047487320934912
       
  • Atherosclerotic cardiovascular disease risk and elevated lipoprotein(a)
           among young adults with myocardial infarction: The Partners YOUNG-MI
           Registry

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      Authors: Adam N Berman, David W Biery, Avinainder Singh, Wanda Y Wu, Sanjay Divakaran, Ersilia M DeFilippis, Jon Hainer, Michael J Blaha, Christopher Cannon, Donna M Polk, Jorge Plutzky, Pradeep Natarajan, Khurram Nasir, Marcelo F Di Carli, Deepak L Bhatt, Ron Blankstein
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-06-16T02:40:35Z
      DOI: 10.1177/2047487320931296
       
  • Statins association with calcification in coronary plaque and heart
           valves: a possible different clinical significance: Montignoso HEart and
           Lung Project (MHELP) study preliminary data in primary cardiovascular
           prevention

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      Authors: Annamaria Mazzone, Alberto Clemente, Silverio Sbrana, Daniele Della Latta, Sara Chiappino, Sergio Berti, Dante Chiappino, Cristina Vassalle
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-06-16T02:40:35Z
      DOI: 10.1177/2047487320932330
       
  • Acute effect of lipoprotein apheresis on coronary flow velocity reserve
           evaluated by the cold pressure test

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      Authors: Francesco Sbrana, Emilio M Pasanisi, Beatrice Dal Pino, Federico Bigazzi, Andrea Ripoli, Tiziana Sampietro
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-06-16T02:40:34Z
      DOI: 10.1177/2047487320931622
       
  • Predicting cardiovascular involvement in systemic sclerosis for a timely
           and better treatment approach

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      Authors: Maria Maddalena Sirufo, Lia Ginaldi, Massimo De Martinis
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-06-16T02:40:34Z
      DOI: 10.1177/2047487320932256
       
  • Treatment gaps and mortality among patients with familial
           

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      Authors: Elad Shemesh, Ameer Azaiza, Barak Zafrir
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-06-16T02:40:33Z
      DOI: 10.1177/2047487320932329
       
  • Determinants of aortic root dilatation over time in patients with
           essential hypertension: The Campania Salute Network

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      Authors: Grazia Canciello, Costantino Mancusi, Raffaele Izzo, Carmine Morisco, Teresa Strisciuglio, Emanuele Barbato, Bruno Trimarco, Nicola De Luca, Giovanni de Simone, Maria Angela Losi
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.
      BackgroundDeterminants of changes of aortic root dimension over time are not well defined.DesignWe investigated whether specific phenotype and treatment exist predicting changes in aortic root dimension in hypertensive patients from the Campania Salute Network.MethodsN = 4856 participants (age 53 ± 11 years, 44% women) were included. At first and last available echocardiograms, we measured aortic root and a z-score of aortic root (AOz) was generated as the difference between measured and predicted aortic root, derived from a healthy reference population. Aortic root dilatation (ARD) was defined as AOz>75th percentile of distribution.ResultsAt baseline, 3642 patients (75%) exhibited normal aortic root, and 1214 (25%) ARD. After a follow-up of 6.1 years (interquartile range 3.0–8.8 years), 366 (11%) patients with initial normal aortic root exhibited ARD, whereas 457(38%) with initial ARD exhibited normal aortic root. At multivariate analysis patients with incident ARD were most likely to be women, obese, with left ventricular hypertrophy, lower systolic but higher diastolic blood pressure and stroke volume index at baseline, and higher average value of diastolic blood pressure during follow-up (p 
      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-06-12T10:17:37Z
      DOI: 10.1177/2047487320931630
       
  • The use of cardiac imaging in the evaluation of athletes in the clinical
           practice: A survey by the Sports Cardiology and Exercise Section of the
           European Association of Preventive Cardiology and University of Siena, in
           collaboration with the European Association of Cardiovascular Imaging, the
           European Heart Rhythm Association and the ESC Working Group on Myocardial
           and Pericardial Diseases

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      Authors: Flavio D’Ascenzi, Francesca Anselmi, Sergio Mondillo, Gherardo Finocchiaro, Stefano Caselli, María Sanz-De La Garza, Christian Schmied, Paolo Emilio Adami, Maurizio Galderisi, Yehuda Adler, Antonis Pantazis, Josef Niebauer, Hein Heidbuchel, Michael Papadakis, Paul Dendale
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.
      AimsPre-participation evaluation (PPE) is recommended to prevent sudden cardiac death in athletes. Although imaging is not advocated as a first-line screening tool, there is a growing interest in the use of echocardiography in PPE of athletes. This survey aimed to map the use of imaging in the setting of PPE and explore physician beliefs and potential barriers that may influence individual practices.MethodsAn international survey of healthcare professionals was performed across ESC Member Countries. Percentages were reported based on the number of respondents per question.ResultsIn total, 603 individuals from 97 countries participated in the survey. Two-thirds (65%) of respondents use echocardiography always or often as part of PPE of competitive athletes and this practice is not influenced by the professional or amateur status of the athlete. The majority (81%) of respondents who use echocardiography as a first-line screening tool perform the first echocardiogram during adolescence or at the first clinical evaluation, and 72% repeat it at least once in the athletes’ career, at 1–5 yearly intervals. In contrast, cardiac magnetic resonance is reserved as a second-line investigation of symptomatic athletes. The majority of the respondents did not report any barriers to echocardiography, while several barriers were identified for cardiac magnetic resonance.ConclusionsEchocardiography is frequently used as a first-line screening tool of athletes. In the absence of scientific evidence, before such practice is recommended, large studies using echocardiography in the PPE setting are necessary.
      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-06-12T10:17:35Z
      DOI: 10.1177/2047487320932018
       
  • Inherited atherogenic dyslipidemias: are they correctly reported'

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      Authors: Tiziana Sampietro, Srefania Pieroni, Sabrina Molinaro, Francesco Sbrana, Beatrice Dal Pino, Federico Bigazzi, Massimiliano Ruscica, Cesare R Sirtori, Michela Franchini
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-06-12T10:17:34Z
      DOI: 10.1177/2047487320930308
       
  • Sinus bradycardia in paediatric athletes

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      Authors: Leonel Diaz-Gonzalez, Vanesa Bruña, Pedro L Valenzuela, Jesús Velásquez-Rodriguez, Araceli Boraita, Alejandro Lucia, Manuel Martinez-Sellés
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-06-10T04:21:12Z
      DOI: 10.1177/2047487320932254
       
  • Cardiac magnetic resonance in patients with muscular dystrophies:
           strengthening the data

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      Authors: Chrysovalantou Nikolaidou, Theodoros D Karamitsos
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-06-10T04:21:12Z
      DOI: 10.1177/2047487320932693
       
  • Managing the complexities of cardiac amyloidosis: a path for success

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      Authors: Clement Eiswirth, Hector O Ventura
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-06-10T04:21:11Z
      DOI: 10.1177/2047487320928178
       
  • Midlife crisis' Keep running against the vascular aging clock!

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      Authors: Andreas B Gevaert, Emeline M Van Craenenbroeck, Christiaan J Vrints
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-06-10T04:21:11Z
      DOI: 10.1177/2047487320930870
       
  • Pre-participation sport screening: Don’t miss focus

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      Authors: Silvia Castelletti, Erik E Solberg
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-06-10T04:21:11Z
      DOI: 10.1177/2047487320931641
       
  • Is it time to treat women differently in the world of heart failure'

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      Authors: Sabha Bhatti
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-06-10T04:21:10Z
      DOI: 10.1177/2047487320931318
       
  • Bempedoic acid: Everything with a place and purpose

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      Authors: Jan Westerink
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-06-06T05:08:29Z
      DOI: 10.1177/2047487320929779
       
  • Optimising implementation of European guidelines on cardiovascular disease
           prevention in clinical practice: what is needed'

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      Authors: Izabella Uchmanowicz, Arno Hoes, Joep Perk, Gabrielle McKee, Margrét Hrönn Svavarsdóttir, Katarzyna Czerwińska-Jelonkiewicz, Arne Janssen, Anna Oleksiak, Paul Dendale, Ian M Graham
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.
      Cardiovascular disease is a model example of a preventable condition for which practice guidelines are particularly important. In 2016, the joint task force created by the European Society of Cardiology (ESC) together with 10 other societies released the new version of the European guidelines on cardiovascular disease prevention. To facilitate the implementation of the ESC guidelines, a dedicated prevention implementation committee has been established within the European Association of Preventive Cardiology. The paper will first explore potential barriers to the guidelines’ implementation. It then develops a discussion that seeks to inform the future development of the committee’s work, including a new definition of the guidelines’ stakeholders (health policy-makers, healthcare professionals and health educators, patient organisations, entrepreneurs and the general public), future activities within four specific areas: strengthening awareness of the guidelines among stakeholders; supporting organisational changes to facilitate the guidelines’ implementation; motivating stakeholders to utilise the guidelines; and present ideas on new implementation strategies. Providing multifaceted cooperation between healthcare professionals, healthcare management executives and health policy-makers, the novel approach proposed in this paper should contribute to a wider use of the 2016 ESC guidelines and produce desired effects of less cardiovascular disease morbidity and mortality. Furthermore, the solutions presented within the paper may constitute a benchmark for the implementation of practice guidelines in other medical disciplines.
      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-06-03T03:39:51Z
      DOI: 10.1177/2047487320926776
       
  • Obesity and cardiovascular risk management is a critical way to reduce
           healthcare resource pressure

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      Authors: Li Chen, Guang Hao
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-06-03T03:39:50Z
      DOI: 10.1177/2047487320929248
       
  • A call for universal criteria of high-intensity interval training in
           cardiac rehabilitation

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      Authors: Wei-guang Li, Zheng Huang, Tao Chen, Xin-an Zhang
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-06-02T11:53:10Z
      DOI: 10.1177/2047487320927618
       
  • Body mass index and outcomes in ischaemic versus non-ischaemic heart
           failure across the spectrum of ejection fraction

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      Authors: Francesco Gentile, Paolo Sciarrone, Elisabet Zamora, Marta De Antonio, Evelyn Santiago, Mar Domingo, Alberto Aimo, Alberto Giannoni, Claudio Passino, Pau Codina, Antoni Bayes-Genis, Josep Lupon, Michele Emdin, Giuseppe Vergaro
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.
      AimsObesity is related to better prognosis in heart failure with either reduced (HFrEF; left ventricular ejection fraction (LVEF)
      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-06-02T11:53:09Z
      DOI: 10.1177/2047487320927610
       
  • Susceptibility to ischaemic heart disease: Focusing on genetic variants
           for ATP-sensitive potassium channel beyond traditional risk factors

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      Authors: Paolo Severino, Andrea D’Amato, Lucrezia Netti, Mariateresa Pucci, Marco V Mariani, Sara Cimino, Lucia I Birtolo, Fabio Infusino, Paolo De Orchi, Raffaele Palmirotta, Domenica Lovero, Franco Silvestris, Viviana Caputo, Antonio Pizzuti, Fabio Miraldi, Viviana Maestrini, Massimo Mancone, Francesco Fedele
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.
      AimsIschaemic heart disease is classically associated with coronary artery disease. Recent evidences showed the correlation between coronary microvascular dysfunction and ischaemic heart disease, even independently of coronary artery disease. Ion channels represent the final effectors of blood flow regulation mechanisms and their genetic variants, in particular of Kir6.2 subunit of the ATP-sensitive potassium channel (KATP), are reported to be involved in ischaemic heart disease susceptibility. The aim of the present study is to evaluate the role of KATP channel and its genetic variants in patients with ischaemic heart disease and evaluate whether differences exist between coronary artery disease and coronary microvascular dysfunction.MethodsA total of 603 consecutive patients with indication for coronary angiography due to suspected myocardial ischaemia were enrolled. Patients were divided into three groups: coronary artery disease (G1), coronary microvascular dysfunction (G2) and normal coronary arteries (G3). Analysis of four single nucleotide polymorphisms (rs5215, rs5216, rs5218 and rs5219) of the KCNJ11 gene encoding for Kir6.2 subunit of the KATP channel was performed.Resultsrs5215 A/A and G/A were significantly more represented in G1, while rs5215 G/G was significantly more represented in G3, rs5216 G/G and C/C were both more represented in G3, rs5218 C/C was more represented in G1 and rs5219 G/A was more represented in G1, while rs5219 G/G was significantly more represented in G2. At multivariate analysis, single nucleotide polymorphism rs5215_G/G seems to represent an ischaemic heart disease independent protective factor.ConclusionsThese results suggest the potential role of KATP genetic variants in ischaemic heart disease susceptibility, as an independent protective factor. They may lead to a future perspective for gene therapy against ischaemic heart disease.
      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-06-02T11:53:07Z
      DOI: 10.1177/2047487320926780
       
  • Lifelong changes in physical activity behaviour through phase II cardiac
           rehabilitation' Still steps to take!

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      Authors: J Claes, R Buys, A Avila, N Cornelis, K Goetschalckx, VA Cornelissen
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-06-02T11:53:06Z
      DOI: 10.1177/2047487320929451
       
  • Leisure time physical activity is associated with improved HDL
           functionality in high cardiovascular risk individuals: a cohort study

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      Authors: Álvaro Hernáez, Maria Trinidad Soria-Florido, Olga Castañer, Xavier Pintó, Ramón Estruch, Jordi Salas-Salvadó, Dolores Corella, Ángel Alonso-Gómez, Miguel Ángel Martínez-González, Helmut Schröder, Emilio Ros, Lluis Serra-Majem, Miquel Fiol, José Lapetra, Enrique Gomez-Gracia, Montserrat Fitó, Camille Lassale
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.
      AimsPhysical activity has consistently been shown to improve cardiovascular health and high-density lipoprotein-cholesterol levels. However, only small and heterogeneous studies have investigated the effect of exercise on high-density lipoprotein functions. Our aim is to evaluate, in the largest observational study to date, the association between leisure time physical activity and a range of high-density lipoprotein functional traits.MethodsThe study sample consisted of 296 Spanish adults at high cardiovascular risk. Usual leisure time physical activity and eight measures of high-density lipoprotein functionality were averaged over two measurements, one year apart. Multivariable linear regression models were used to explore the association between leisure time physical activity (exposure) and each high-density lipoprotein functional trait (outcome), adjusted for cardiovascular risk factors.ResultsHigher levels of leisure time physical activity were positively and linearly associated with average levels over one year of plasma high-density lipoprotein-cholesterol and apolipoprotein A-I, paraoxonase-1 antioxidant activity, high-density lipoprotein capacity to esterify cholesterol and cholesterol efflux capacity in individuals free of type 2 diabetes only. The increased cholesterol esterification index with increasing leisure time physical activity reached a plateau at around 300 metabolic equivalents.min/day. In individuals with diabetes, the relationship with cholesteryl ester transfer protein followed a U-shape, with a decreased cholesteryl ester transfer protein activity from 0 to 300 metabolic equivalents.min/day, but increasing from there onwards. Increasing levels of leisure time physical activity were associated with poorer high-density lipoprotein vasodilatory capacity.ConclusionsIn a high cardiovascular risk population, leisure time physical activity was associated not only with greater circulating levels of high-density lipoprotein-cholesterol, but also with better markers of high-density lipoprotein functionality, namely cholesterol efflux capacity, the capacity of high-density lipoprotein to esterify cholesterol and paraoxonase-1 antioxidant activity in individuals free of diabetes and lower cholesteryl ester transfer protein activity in individuals with type 2 diabetes.
      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-06-02T11:53:05Z
      DOI: 10.1177/2047487320925625
       
  • Socioeconomic status matters: How can we individualize cardiac
           rehabilitation according to different socioeconomic needs'

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      Authors: David Niederseer, Christian Schmied
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-06-02T11:53:05Z
      DOI: 10.1177/2047487320931309
       
  • The bi- (or multi-) phasic response of cardiac remodelling to endurance
           exercise related to the article: ‘From talented child to elite athlete:
           The development of cardiac morphology and function in a cohort of
           endurance athletes from age 12 to 18’ by Bjerring and colleagues

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      Authors: Martin Burtscher
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-06-02T11:53:04Z
      DOI: 10.1177/2047487320929245
       
  • Impact of environmental pollution and weather changes on the incidence of
           ST-elevation myocardial infarction

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      Authors: Giuseppe Biondi-Zoccai, Giacomo Frati, Achille Gaspardone, Enrica Mariano, Alessandro D Di Giosa, Andrea Bolignano, Angela Dei Giudici, Simone Calcagno, Massimiliano Scappaticci, Sebastiano Sciarretta, Valentina Valenti, Rebecca Casati, Giuseppe Visconti, Maria Penco, Maria B Giannico, Mariangela Peruzzi, Elena Cavarretta, Simone Budassi, Joseph Cosma, Massimo Federici, Leonardo Roever, Francesco Romeo, Francesco Versaci
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.
      BackgroundEnvironmental pollution and weather changes unfavorably impact on cardiovascular disease. However, limited research has focused on ST-elevation myocardial infarction (STEMI), the most severe yet distinctive form of acute coronary syndrome.Methods and resultsWe appraised the impact of environmental and weather changes on the incidence of STEMI, analysing the bivariate and multivariable association between several environmental and atmospheric parameters and the daily incidence of STEMI in two large Italian urban areas. Specifically, we appraised: carbon monoxide (CO), nitrogen dioxide (NO2), nitric oxide (NOX), ozone, particulate matter smaller than 10 μm (PM10) and than 2.5 μm (PM2.5), temperature, atmospheric pressure, humidity and rainfall. A total of 4285 days at risk were appraised, with 3473 cases of STEMI. Specifically, no STEMI occurred in 1920 (44.8%) days, whereas one or more occurred in the remaining 2365 (55.2%) days. Multilevel modelling identified several pollution and weather predictors of STEMI. In particular, concentrations of CO (p=0.024), NOX (p=0.039), ozone (p=0.003), PM10 (p=0.033) and PM2.5 (p=0.042) predicted STEMI as early as three days before the event, as well as subsequently, and NO predicted STEMI one day before (p = 0.010), as well as on the same day. A similar predictive role was evident for temperature and atmospheric pressure (all p 
      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-06-02T11:53:03Z
      DOI: 10.1177/2047487320928450
       
  • Clinical correlates and outcome of the patterns of premature ventricular
           beats in Olympic athletes: a long-term follow-up study

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      Authors: Antonio Pelliccia, Lorena De Martino, Cristian Borrazzo, Andrea Serdoz, Erika Lemme, Alessandro Zorzi, Domenico Corrado
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.
      BackgroundThe pattern of premature ventricular beats, as a clue to site of origin, may help identify underlying cardiac diseases.AimTo assess the value of premature ventricular beat patterns in managing athletes with ventricular arrhythmias.MethodsAthletes with 50 or more isolated premature ventricular beats/24 hours, and/or multifocal and/or repetitive premature ventricular beats at baseline, and/or exercise, and/or 24-hour electrocardiograms were selected for this analysis. Premature ventricular beats were defined as ‘common’ (outflow tract or fascicular origin), or ‘uncommon’ (other morphologies and/or multifocal or repetitive).ResultsFrom 4595 athletes consecutively examined, 205 (4%, 24.6 ± 6.9 years, 67% men) were included, 118 (58%) with uncommon and 87 (42%) with common premature ventricular beats. In particular, 81 (39%) showed complex patterns; 63 (31%) right/left ventricular outflow tract origin; 24 (12%) fascicular origin; 20 (10%) right bundle branch block pattern, intermediate/superior axis, wide QRS; and 17 (8%) left bundle branch block pattern, intermediate/superior axis. Uncommon premature ventricular beat patterns were predominant among men (62% vs. 38%; P 
      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-06-02T11:53:03Z
      DOI: 10.1177/2047487320928452
       
  • Reference values for systolic blood pressure at upright bicycle exercise
           tests

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      Authors: Alfred Hager
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-06-02T11:53:02Z
      DOI: 10.1177/2047487320922924
       
  • Overcoming challenges in preventive cardiology research

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      Authors: Eugenia Gianos, Karina W Davidson
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-06-02T11:53:02Z
      DOI: 10.1177/2047487320928175
       
  • Balancing cardiac rehabilitation for elderly

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      Authors: Tim Kambic, Mitja Lainscak
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-06-02T11:53:02Z
      DOI: 10.1177/2047487320930867
       
  • Standardization and quality improvement of secondary prevention through
           cardiovascular rehabilitation programmes in Europe: The avenue towards
           EAPC accreditation programme: A position statement of the Secondary
           Prevention and Rehabilitation Section of the European Association of
           Preventive Cardiology (EAPC)

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      Authors: Ana Abreu, Ines Frederix, Paul Dendale, Arne Janssen, Patrick Doherty, Massimo F Piepoli, Heinz Völler, Constantinos H Davos
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.
      Despite the proven efficacy and cost-effectiveness of contemporary cardiovascular rehabilitation programmes, the referral to/uptake of and adherence to cardiovascular rehabilitation remains inadequate. In addition, heterogeneity persists amongst different cardiovascular rehabilitation centres in Europe, despite the available scientific documents describing the evidence-based rehabilitation format/content. This position statement was elaborated by the Secondary Prevention and Rehabilitation (SP/CR) section of EAPC. It defines the minimal and optimal cardiovascular rehabilitation standards. In addition, it describes the relevant quality indicators of cardiovascular rehabilitation programmes to date. Compliance of European cardiovascular rehabilitation centres with these standards will improve cardiovascular rehabilitation process standardization in Europe and hence increase the quality of cadiovascular rehabilitation programmes.
      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-06-01T08:22:54Z
      DOI: 10.1177/2047487320924912
       
  • Age matters: differences in exercise-induced cardiovascular remodelling in
           young and middle aged healthy sedentary individuals

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      Authors: Camilla Torlasco, Andrew D’Silva, Anish N Bhuva, Andrea Faini, Joao B Augusto, Kristopher D Knott, Giulia Benedetti, Siana Jones, Jet Van Zalen, Paul Scully, Ilaria Lobascio, Gianfranco Parati, Guy Lloyd, Alun D Hughes, Charlotte H Manisty, Sanjay Sharma, James C Moon
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.
      AimsRemodelling of the cardiovascular system (including heart and vasculature) is a dynamic process influenced by multiple physiological and pathological factors. We sought to understand whether remodelling in response to a stimulus, exercise training, altered with healthy ageing.MethodsA total of 237 untrained healthy male and female subjects volunteering for their first time marathon were recruited. At baseline and after 6 months of unsupervised training, race completers underwent tests including 1.5T cardiac magnetic resonance, brachial and non-invasive central blood pressure assessment. For analysis, runners were divided by age into under or over 35 years (U35, O35).ResultsInjury and completion rates were similar among the groups; 138 runners (U35: n = 71, women 49%; O35: n = 67, women 51%) completed the race. On average, U35 were faster by 37 minutes (12%). Training induced a small increase in left ventricular mass in both groups (3 g/m2, P 
      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-06-01T05:31:26Z
      DOI: 10.1177/2047487320926305
       
  • Aspirin-free strategy versus standard term dual antiplatelet therapy in
           patients undergoing percutaneous coronary intervention: a meta-analysis of
           randomized controlled trials

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      Authors: Mohammad Saud Khan, Abdelmoniem Moustafa, Abdullah Zoheb Azhar, Abdur Rahman Khan, Sohail Ikram
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-05-29T06:30:57Z
      DOI: 10.1177/2047487320925623
       
  • Obesity, cardiovascular risk and healthcare resource utilization in the UK

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      Authors: Carel W le Roux, Niels V Hartvig, Christiane Lundegaard Haase, Rikke Baastrup Nordsborg, Anne Helene Olsen, Altynai Satylganova
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.
      AimsObesity and cardiovascular diseases (CVDs) often co-occur, likely increasing the intensity of healthcare resource utilization (HCRU). This retrospective, observational database study examined the joint effect of obesity and cardiovascular risk status on HCRU and compared HCRU between body mass index (BMI) categories and CVD-risk categories in the UK.MethodsPatient demographics and data on CVD and BMI were obtained from the UK Clinical Practice Research Datalink. Cardiovascular risk status, calculated using the Framingham Risk Equation, was used to categorize people into high-risk and low-risk groups, while a CVD diagnosis was used to define the established CVD group. Patients were split into BMI categories using the standard World Health Organization classifications. For each CVD and BMI category, mean number and costs of general practitioner contacts, hospital admissions and prescriptions were estimated.ResultsThe final study population included 1,600,709 patients. Data on CVD status were available on just over one-quarter of the sample (28.6%) and BMI data for just less than half (43.2%). The number of general practitioner contacts and prescriptions increased with increasing BMI category for each of the three CVD-risk groups. The group with established CVD had the greatest utilization of all components of healthcare resource, followed by high CVD risk then low CVD-risk groups.ConclusionIncreasing BMI category and CVD-risk status both affected several HCRU components. These findings highlight the importance of timely obesity management and treatment of CVD-risk factors as a means of preventing increasing HCRU.
      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-05-28T06:33:02Z
      DOI: 10.1177/2047487320925639
       
  • Traffic-related air pollution and the coronavirus pandemia: shadows and
           lights

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      Authors: Pier Mannuccio Mannucci
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-05-28T06:33:01Z
      DOI: 10.1177/2047487320928451
       
  • Lipoprotein(a) reduction with proprotein convertase subtilisin/kexin type
           9 inhibitors: An unsolved mystery

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      Authors: Evangelos Liberopoulos
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-05-23T06:07:08Z
      DOI: 10.1177/2047487320926777
       
  • Physical activity/inactivity and COVID-19

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      Authors: Antonio Crisafulli, Pasquale Pagliaro
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-05-19T06:44:00Z
      DOI: 10.1177/2047487320927597
       
  • Personalized screening intervals for measurement of N-terminal pro-B-type
           natriuretic peptide improve efficiency of prognostication in patients with
           chronic heart failure

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      Authors: Anne-Sophie Schuurman, Anirudh Tomer, K Martijn Akkerhuis, Jasper J Brugts, Alina A Constantinescu, Jan van Ramshorst, Victor A Umans, Eric Boersma, Dimitris Rizopoulos, Isabella Kardys
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-05-16T09:00:52Z
      DOI: 10.1177/2047487320922639
       
  • Cardiac magnetic resonance in patients with muscular dystrophies

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      Authors: Chrysanthos Grigoratos, Alberto Aimo, Andrea Barison, Vincenzo Castiglione, Giancarlo Todiere, Giulia Ricci, Gabriele Siciliano, Michele Emdin
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.
      Muscular dystrophies are inherited disorders sharing similar clinical features and dystrophic changes on muscle biopsy. Duchenne muscular dystrophy is the most common inherited muscle disease of childhood, and Becker muscular dystrophy is a milder allelic variant with a slightly lower prevalence. Myotonic dystrophy is the most frequent form in adults. Cardiac magnetic resonance is the gold standard technique for the quantification of cardiac chamber volumes and function, and also enables a characterisation of myocardial tissue. Most cardiac magnetic resonance studies in the setting of muscular dystrophy were carried out at single centres, evaluated small numbers of patients and used widely heterogeneous protocols. Even more importantly, those studies analysed more or less extensively the patterns of cardiac involvement, but usually did not try to establish the added value of cardiac magnetic resonance to standard echocardiography, the evolution of cardiac disease over time and the prognostic significance of cardiac magnetic resonance findings. As a result, the large and heterogeneous amount of information on cardiac involvement in muscular dystrophies cannot easily be translated into recommendations on the optimal use of cardiac magnetic resonance. In this review, whose targets are cardiologists and neurologists who manage patients with muscular dystrophy, we try to summarise cardiac magnetic resonance findings in patients with muscular dystrophy, and the results of studies evaluating the role of cardiac magnetic resonance as a tool for diagnosis, risk stratification and follow-up. Finally, we provide some practical recommendations about the need and timing of cardiac magnetic resonance examination for the management of patients with muscular dystrophy.
      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-05-16T09:00:52Z
      DOI: 10.1177/2047487320923052
       
  • A window of opportunity on cardiovascular prevention: pre-eclampsia and
           fetal growth restriction

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      Authors: Edoardo Sciatti, Rossana Orabona
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-05-16T09:00:51Z
      DOI: 10.1177/2047487320925646
       
  • Personalised rehabilitation for cardiac and pulmonary patients with
           multimorbidity: Time for implementation'

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      Authors: Rod S Taylor, Sally Singh
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-05-16T09:00:50Z
      DOI: 10.1177/2047487320926058
       
  • Short-term mortality risk of different plasma potassium levels in patients
           treated with combination antihypertensive therapy

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      Authors: Maria L Krogager, Christian Torp-Pedersen
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-05-16T09:00:49Z
      DOI: 10.1177/2047487320925220
       
  • How do General Practitioners assess physical activity and prescribe
           exercise in patients with different cardiovascular diseases' An
           Italian pilot study

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      Authors: Giulia Foccardi, Dominique Hansen, Giulia Quinto, Claudia Favero, Karin Coninx, Gustavo Rovelo Ruiz, Paul Dendale, Josef Niebauer, Andrea Ermolao, Daniel Neunhaeuserer
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-05-16T09:00:49Z
      DOI: 10.1177/2047487320925221
       
  • Physical activity, sports and risk of atrial fibrillation: umbrella review
           of meta-analyses

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      Authors: Pedro L Valenzuela, Alejandro Santos-Lozano, Javier S Morales, Susana López-Ortiz, José Pinto-Fraga, Adrián Castillo-García, Juan Martín-Hernández, Julián P Villacastín, Araceli Boraita, Alejandro Lucia
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-05-16T09:00:48Z
      DOI: 10.1177/2047487320923183
       
  • Rationale, design and baseline characteristics of the MyoVasc study: A
           prospective cohort study investigating development and progression of
           heart failure

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      Authors: Sebastian Göbel, Jürgen H Prochaska, Sven-Oliver Tröbs, Marina Panova-Noeva, Christine Espinola–Klein, Matthias Michal, Karl J Lackner, Tommaso Gori, Thomas Münzel, Philipp S Wild
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.
      BackgroundHeart failure (HF) is a poly-aetiological syndrome with large heterogeneity regarding clinical presentation, pathophysiology, clinical outcome and response to therapy. The MyoVasc study (NCT04064450) is an epidemiological cohort study investigating the development and progression of HF.MethodsThe primary objective of the study is (a) to improve the understanding of the pathomechanisms of HF across the full spectrum of clinical presentation, (b) to investigate the current clinical classifications of HF, and (c) to identify and characterize homogeneous subgroups regarding disease development using a systems-oriented approach. Worsening of HF, that is, the composite of transition from asymptomatic to symptomatic HF, hospitalization due to HF, or cardiac death, was defined as the primary endpoint of the study. During a six-year follow-up period, all study participants receive a highly standardized, biannual five-hour examination in a dedicated study centre, including detailed cardiovascular phenotyping and biobanking of various biomaterials. Annual follow-up examinations are conducted by computer-assisted telephone interviews recording comprehensively the participants´ health status, including subsequent validation and adjudication of adverse events.ResultsIn total, 3289 study participants (age range: 35 to 84 years; female sex: 36.8%) including the full range of HF stages were enrolled from 2013 to 2018. Approximately half of the subjects (n=1741) presented at baseline with symptomatic HF (i.e. HF stage C/D). Among these, HF with preserved ejection fraction was the most frequent phenotype.ConclusionsBy providing a large-scale, multi-dimensional biodatabase with sequential, comprehensive medical-technical (sub)clinical phenotyping and multi-omics characterization (i.e. genome, transcriptome, proteome, lipidome, metabolome and exposome), the MyoVasc study will help to advance our knowledge about the heterogeneous HF syndrome by a systems-oriented biomedicine approach.Trial registrationClinicalTrials.gov; NCT04064450.
      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-05-15T03:59:46Z
      DOI: 10.1177/2047487320926438
       
  • The reward of understanding risk in atrial fibrillation

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      Authors: Zak Loring, Jonathan P Piccini
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-05-14T03:45:07Z
      DOI: 10.1177/2047487320925215
       
  • Is the novel LDL-cholesterol goal

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      Authors: John Munkhaugen, Elise Sverre, Kari Peersen, Oscar Kristiansen, Erik Gjertsen, Lars Gullestad, Jan Erik Otterstad
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-05-13T02:59:17Z
      DOI: 10.1177/2047487320923187
       
  • Impact of sex-specific target dose in chronic heart failure patients with
           reduced ejection fraction

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      Authors: Jesse F Veenis, Hans-Peter Brunner-La Rocca, Gerard CM Linssen, Ayten Erol-Yilmaz, Arjen CB Pronk, Domien JM Engelen, Rob M van Tooren, Hetty JJ Koornstra-Wortel, Rudolf A de Boer, Peter van der Meer, Arno W Hoes, Jasper J Brugts
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.
      AimsA recent study suggested that women with heart failure and heart failure reduced ejection fraction might hypothetically need lower doses of angiotensin-converting enzyme inhibitors or angiotensin II receptor blockers ( = renin-angiotensin-system inhibitors) and β-blockers than men to achieve the best outcome. We assessed the current medical treatment of heart failure reduced ejection fraction in men and women in a large contemporary cohort and address the hypothetical impact of changing treatment levels in women.MethodsThis analysis is part of a large contemporary quality of heart failure care project which includes 5320 (64%) men and 3003 (36%) women with heart failure reduced ejection fraction. Detailed information on heart failure therapy prescription and dosage were collected.ResultsWomen less often received renin-angiotensin-system inhibitors (79% vs 83%, p 
      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-05-13T02:59:16Z
      DOI: 10.1177/2047487320923185
       
  • Preexisting coronary heart disease and susceptibility to long-term effects
           of traffic-related air pollution: A matched cohort analysis

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      Authors: Gali Cohen, David M Steinberg, Lital Keinan-Boker, Yuval, Ilan Levy, Shimon Chen, Rakefet Shafran-Nathan, Noam Levin, Tal Shimony, Guy Witberg, Tamir Bental, Tamar Shohat, David M Broday, Ran Kornowski, Yariv Gerber
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.
      BackgroundIndividuals with coronary heart disease are considered susceptible to traffic-related air pollution exposure. Yet, cohort-based evidence on whether preexisting coronary heart disease modifies the association of traffic-related air pollution with health outcomes is lacking.AimUsing data of four Israeli cohorts, we compared associations of traffic-related air pollution with mortality and cancer between coronary heart disease patients and matched controls from the general population.MethodsSubjects hospitalized with acute coronary syndrome from two patient cohorts (inception years: 1992–1993 and 2006–2014) were age- and sex-matched to coronary heart disease-free participants of two cycles of the Israeli National Health and Nutrition Surveys (inception years: 1999–2001 and 2005–2006). Ambient concentrations of nitrogen oxides at the residential place served as a proxy for traffic-related air pollution exposure across all cohorts, based on a high-resolution national land use regression model (50 m). Data on all-cause mortality (last update: 2018) and cancer incidence (last update: 2016) were retrieved from national registries. Cox-derived stratum-specific hazard ratios with 95% confidence intervals were calculated, adjusted for harmonized covariates across cohorts, including age, sex, ethnicity, neighborhood socioeconomic status, smoking, diabetes, hypertension, prior stroke and prior malignancy (the latter only in the mortality analysis). Effect-modification was examined by testing nitrogen oxides-by-coronary heart disease interaction term in the entire matched cohort.ResultsThe cohort (mean (standard deviation) age 61.5 (14) years; 44% women) included 2393 matched pairs, among them 2040 were cancer-free at baseline. During a median (25th–75th percentiles) follow-up of 13 (10–19) and 11 (7–17) years, 1458 deaths and 536 new cancer cases were identified, respectively. In multivariable-adjusted models, a 10-parts per billion nitrogen oxides increment was positively associated with all-cause mortality among coronary heart disease patients (hazard ratio = 1.13, 95% confidence interval 1.05–1.22), but not among controls (hazard ratio = 1.00, 0.93–1.08) (pinteraction = 0.003). A similar pattern was seen for all-cancer incidence (hazard ratioCHD = 1.19 (1.03–1.37), hazard ratioCHD-Free = 0.93 (0.84–1.04) (pinteraction = 0.01)). Associations were robust to multiple sensitivity analyses.ConclusionsCoronary heart disease patients might be at increased risk for traffic-related air pollution-associated mortality and cancer, irrespective of their age and sex. Patients and clinicians should be more aware of the adverse health effects on coronary heart disease patients of chronic exposure to vehicle emissions.
      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-05-09T12:42:56Z
      DOI: 10.1177/2047487320921987
       
  • Risk of osteoporotic fracture in older patients under antihypertensive
           treatment

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      Authors: Oh Kyung Kwon, Sun-Hwa Kim, Si-Hyuck Kang, Young-Kyun Lee, Chang-Hwan Yoon, Hae-Young Lee, Tae-Jin Youn, In-Ho Chae, Cheol-Ho Kim
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-05-09T12:42:56Z
      DOI: 10.1177/2047487320923054
       
  • Extracellular vesicle species differentially affect endothelial cell
           functions and differentially respond to exercise training in patients with
           chronic coronary syndromes

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      Authors: Nicolle Kränkel, Elisabeth Strässler, Madlen Uhlemann, Maja Müller, Sylvie Briand-Schumacher, Roland Klingenberg, P Christian Schulze, Volker Adams, Gerhard Schuler, Thomas F Lüscher, Sven Möbius-Winkler, Ulf Landmesser
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.
      BackgroundExtracellular vesicles are released upon cellular activation and mediate inter-cellular communication. Individual species of extracellular vesicles might have divergent roles in vascular homeostasis and may show different responses to therapies such as exercise training.AimsWe examine endothelial effects of medium-size and small extracellular vesicles from the same individual with or without chronic coronary syndrome, and in chronic coronary syndrome patients participating in a four-week high-intensity interval training intervention.MethodsHuman aortic endothelial cells were exposed to medium-size extracellular vesicles and small extracellular vesicles isolated from plasma samples of study participants. Endothelial cell survival, activation and re-endothelialisation capacity were assessed by respective staining protocols. Extracellular vesicles were quantified by nanoparticle tracking analysis and flow cytometry. Extracellular vesicle microRNA expression was quantified by realtime-quantitative polymerase chain reaction.ResultsIn patients with chronic coronary syndrome (n = 25), plasma counts of leukocyte-derived medium-size extracellular vesicles were higher than in age-matched healthy controls (n = 25; p = 0.04) and were reduced by high-intensity interval training (n = 15; p = 0.01 vs baseline). Re-endothelialisation capacity was promoted by medium-size extracellular vesicles from controls, but not by medium-size extracellular vesicles from chronic coronary syndrome patients. High-intensity interval training for 4 weeks enhanced medium-size extracellular vesicle-mediated support of in vitro re-endothelialisation. Small extracellular vesicles from controls or chronic coronary syndrome patients increased endothelial cell death and reduced repair functions and were not affected by high-intensity interval training.ConclusionThe present study demonstrates that medium-size extracellular vesicles and small extracellular vesicles differentially affect endothelial cell survival and repair responses. This equilibrium is unbalanced in patients with chronic coronary syndrome where leukocyte-derived medium-size extracellular vesicles are increased leading to a loss of medium-size extracellular vesicle-mediated endothelial repair. High-intensity interval training partially restored medium-size extracellular vesicle-mediated endothelial repair, underlining its use in cardiovascular prevention and therapy to improve endothelial function.
      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-05-08T01:59:39Z
      DOI: 10.1177/2047487320919894
       
  • Polycystic ovary syndrome as a novel risk factor for atrial fibrillation:
           results from a national Danish registry cohort study

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      Authors: Clare Oliver-Williams, Ditte Vassard, Anja Pinborg, Lone Schmidt
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-05-07T12:00:05Z
      DOI: 10.1177/2047487320922927
       
  • Cardiovascular risk profile and events before and after treatment with
           anti-VEGF drugs in the setting of a structured cardio-oncologic program

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      Authors: Giacomo Tini, Matteo Sarocchi, Davide Sirello, Roberto Murialdo, Giuseppe Fornarini, Giulia Buzzatti, Francesco Boccardo, Eleonora Arboscello, Italo Porto, Pietro Ameri, Paolo Spallarossa
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-05-07T01:34:48Z
      DOI: 10.1177/2047487320923056
       
  • Workload-indexed blood pressure response to a maximum exercise test among
           professional indoor athletes

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      Authors: Pascal Bauer, Lutz Kraushaar, Oliver Dörr, Holger Nef, Christian W Hamm, Astrid Most
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.
      BackgroundExercise testing is performed regularly in professional athletes. However, the blood pressure response (BPR) to exercise is rarely investigated in this cohort, and normative upper thresholds are lacking. Recently, a workload-indexed BPR (increase in systolic blood pressure per increase in metabolic equivalent of task (SBP/MET slope)) was evaluated in a general population and was compared with mortality. We sought to evaluate the SBP/MET slope in professional athletes and compare it with performance.DesignThis was a cross-sectional study.MethodsA total of 142 male professional indoor athletes (age 26 ± 5 years) were examined. Blood pressure was measured at rest and during a standardized, graded cycle ergometer test. We assessed the BPR during exercise, the workload, and the metabolic equivalent of task (MET). Athletes were divided into groups according to their SBP/MET slope quartiles (I 6.2–9; IV>9 mmHg/MET) and compared regarding systolic BP (sBP) and workload achieved.ResultsAthletes in group I (n = 42) had the lowest maximum sBP (180 ± 13 mmHg) but achieved the highest relative workload (4.2 ± 1 W/kg). With increasing SBP/MET slope, the maximum sBP increased (II (n = 56): 195 ± 15 mmHg; III (n = 44): 216 ± 16 mmHg) and the workload achieved decreased (II: 3.9 ± 0.7 W/kg; III: 3.3 ± 0.5 W/kg). The differences in sBP between these groups were significant (p 9 mmHg/MET).ConclusionAthletes in the lowest SBP/MET slope quartile displayed the lowest maximum sBP but achieved a higher workload than athletes classified into the other SBP/MET slope groups. This simple, novel metric might help to distinguish a normal from an exaggerated BPR to exercise, to identify athletes at risk of developing hypertension.
      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-05-07T01:34:46Z
      DOI: 10.1177/2047487320922043
       
  • Prevalence and determinants of the precursor stages of heart failure:
           results from the population-based STAAB cohort study

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      Authors: Caroline Morbach, Götz Gelbrich, Theresa Tiffe, Felizitas A Eichner, Martin Christa, Renate Mattern, Margret Breunig, Vladimir Cejka, Martin Wagner, Peter U Heuschmann, Stefan Störk
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.
      AimsPrevention of heart failure relies on the early identification and control of risk factors. We aimed to identify the frequency and characteristics of individuals at risk of heart failure in the general population.Methods and ResultsWe report cross-sectional data from the prospective Characteristics and Course of Heart Failure Stages A–B and Determinants of Progression (STAAB) cohort study investigating a representative sample of residents of Würzburg, Germany. Sampling was stratified 1:1 for sex and 10:27:27:27:10 for age groups of 30–39/40–49/50–59/60–69/70–79 years. Heart failure precursor stages were defined according to American College of Cardiology/American Heart Association: stage A (risk factors for heart failure), stage B (asymptomatic cardiac dysfunction). The main results were internally validated in the second half of the participants. The derivation sample comprised 2473 participants (51% women) with a distribution of 10%/28%/25%/27%/10% in respective age groups. Stages A and B were prevalent in 42% and 17% of subjects, respectively. Of stage B subjects, 31% had no risk factor qualifying for stage A (group ‘B-not-A’). Compared to individuals in stage B with A criteria, B-not-A were younger, more often women, and had left ventricular dilation as the predominant B qualifying criterion (all P 
      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-05-07T01:34:45Z
      DOI: 10.1177/2047487320922636
       
  • ECG screening in master athletes: ‘Medical science has made such
           tremendous progress that there is hardly a healthy human left.’

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      Authors: Alain Braillon
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-05-06T02:12:00Z
      DOI: 10.1177/2047487320922634
       
  • Big data, social determinants of coronary heart disease and barriers for
           data access

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      Authors: Abraham IJ Gajardo, Fabián Henríquez, Marcelo Llancaqueo
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-05-04T02:45:40Z
      DOI: 10.1177/2047487320922366
       
  • Authors’ reply to ‘Reference values for systolic blood pressure at
           upright bicycle exercise tests’ by Alfred Hager

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      Authors: Kristofer Hedman, Thomas Lindow, Viktor Elmberg, Lars Brudin, Magnus Ekström
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-04-30T04:55:48Z
      DOI: 10.1177/2047487320923055
       
  • Non-invasive estimation of stroke volume during exercise from oxygen in
           heart failure patients

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      Authors: Emanuele Accalai, Carlo Vignati, Elisabetta Salvioni, Beatrice Pezzuto, Mauro Contini, Christian Cadeddu, Luigi Meloni, Piergiuseppe Agostoni
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.
      AimsIn heart failure, oxygen uptake and cardiac output measurements at peak and during exercise are important in defining heart failure severity and prognosis. Several cardiopulmonary exercise test-derived parameters have been proposed to estimate stroke volume during exercise, including the oxygen pulse (oxygen uptake/heart rate). Data comparing measured stroke volume and the oxygen pulse or stroke volume estimates from the oxygen pulse at different stages of exercise in a sizeable population of healthy individuals and heart failure patients are lacking.MethodsWe analysed 1007 subjects, including 500 healthy and 507 heart failure patients, who underwent cardiopulmonary exercise testing with stroke volume determination by the inert gas rebreathing technique. Stroke volume measurements were made at rest, submaximal (∼50% of exercise) and peak exercise. At each stage of exercise, stroke volume estimates were obtained considering measured haemoglobin at rest, predicted exercise-induced haemoconcentration and peripheral oxygen extraction according to heart failure severity.ResultsA strong relationship between oxygen pulse and measured stroke volume was observed in healthy and heart failure subjects at submaximal (R2 = 0.6437 and R2 = 0.6723, respectively), and peak exercise (R2 = 0.6614 and R2 = 0.5662) but not at rest. In healthy and heart failure subjects, agreement between estimated and measured stroke volume was observed at submaximal (–3 ± 37 and –11 ± 72 ml, respectively) and peak exercise (1 ± 31 and 6 ± 29 ml, respectively) but not at rest.ConclusionIn heart failure patients, stroke volume estimation and oxygen pulse during exercise represent stroke volume, albeit with a relevant individual data dispersion so that both can be used for population studies but cannot be reliably applied to a single subject. Accordingly, whenever needed stroke volume must be measured directly.
      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-04-29T01:32:26Z
      DOI: 10.1177/2047487320920755
       
  • Abdominal aortic calcification: from ancient friend to modern foe

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      Authors: Jonas W Bartstra, Willem PThM Mali, Wilko Spiering, Pim A de Jong
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.
      BackgroundAbdominal aortic calcifications were already ubiquitous in ancient populations from all continents. Although nowadays generally considered as an innocent end stage of stabilised atherosclerotic plaques, increasing evidence suggests that arterial calcifications contribute to cardiovascular risk. In this review we address abdominal aortic calcification from an evolutionary perspective and review the literature on histology, prevalence, risk factors, clinical outcomes and pharmacological interventions of abdominal aortic calcification.DesignThe design of this study was based on a literature review.MethodsPubmed and Embase were systematically searched for articles on abdominal aortic calcification and its synonyms without language restrictions. Articles with data on histology, prevalence, risk factors clinical outcomes and/or pharmacological interventions were selected.ResultsAbdominal aortic calcification is highly prevalent in the general population and prevalence and extent increase with age. Prevalence and risk factors differ between males and females and different ethnicities. Risk factors include traditional cardiovascular risk factors and decreased bone mineral density. Abdominal aortic calcification is shown to contribute to arterial stiffness and is a strong predictor of cardiovascular events and mortality. Several therapies to inhibit arterial calcification have been developed and investigated in small clinical trials.ConclusionsAbdominal aortic calcification is from all eras and increasingly acknowledged as an independent contributor to cardiovascular disease. Large studies with long follow-up must be carried out to show whether inhibition of abdominal aortic calcification will further reduce cardiovascular risk.
      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-04-29T01:32:23Z
      DOI: 10.1177/2047487320919895
       
  • The effect of cardiovascular fitness in men with cancer and cardiovascular
           disease

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      Authors: Erlinda The
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-04-29T01:32:22Z
      DOI: 10.1177/2047487320922925
       
  • From talented child to elite athlete: The development of cardiac
           morphology and function in a cohort of endurance athletes from age 12 to
           18

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      Authors: Anders W Bjerring, Hege EW Landgraff, Svein Leirstein, Kristina H Haugaa, Thor Edvardsen, Sebastian I Sarvari, Jostein Hallén
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.
      BackgroundAdult athletes undergo cardiac adaptions in what is known as the “athlete’s heart”. Cardiac adaptations in young athletes have not been described in longitudinal studies but have previously been believed to be uniform in nature.MethodsSeventy-six cross-country skiers were assessed at age 12. Forty-eight (63%) completed the first follow-up at age 15 and 36 (47%) the second follow-up at age 18. Comprehensive exercise data were collected. Echocardiography with three-dimensional measurements and cardiopulmonary exercise testing were performed at all time points. The cohort was divided into active and former endurance athletes, with an eight hours of weekly endurance exercise cut-off at age 18.ResultsThe athletes underwent eccentric remodelling between ages 12 and 15, and concentric remodelling between ages 15 and 18. At age 18, the active endurance athletes had greater increases in inter-ventricular wall thickness (1.8 ± 1.4 Δmm vs 0.6 ± 1.0 Δmm, p 
      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-04-29T01:32:21Z
      DOI: 10.1177/2047487320921317
       
  • Correspondence to the EJPC in response to position paper by Ambrosetti M
           et al. 2020: Cardiovascular rehabilitation and COVID-19: The need to
           maintain access to evidence-based services from the safety of home

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      Authors: Hasnain Dalal, Rod S Taylor, Colin Greaves, Patrick J Doherty, Sinead TJ McDonagh, Samantha B van Beurden, Carrie Purcell
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-04-28T08:52:55Z
      DOI: 10.1177/2047487320923053
       
  • Increased functional capacity after 12 weeks of exercise training does not
           transform into improved skeletal muscle metabolism or ultrastructure in
           heart failure patients on modern optimal medical therapy

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      Authors: Torstein Valborgland, Kjetil Isaksen, Arne Yndestad, Sigurd Lindal, Kate Myreng, Peter Scott Munk, Alf Inge Larsen
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-04-28T03:36:29Z
      DOI: 10.1177/2047487320919863
       
  • Lipid-lowering statin therapy is beneficial in elderly female patients
           with hypercholesterolaemia and diabetic retinopathy

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      Authors: Yoshihiro Saito, Atsuko Nakayama, Tatsuyuki Sato, Hiroyuki Morita, Takuya Kawahara, Hiroshi Itoh, Issei Komuro
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-04-28T03:36:29Z
      DOI: 10.1177/2047487320920761
       
  • Greater burden of risk factors and less effect of cardiac rehabilitation
           in elderly with low educational attainment: The Eu-CaRE study

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      Authors: Ingunn E Kjesbu, Nicolai Mikkelsen, Kirstine L Sibilitz, Matthias Wilhelm, Carlos Pena-Gil, Violeta González-Salvado, Marie Christine Iliou, Uwe Zeymer, Esther P Meindersma, Diego Ardissino, Astrid E van der Velde, Arnoud WJ Van ‘t Hof, Ed P de Kluiver, Eva Prescott
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-04-28T03:36:27Z
      DOI: 10.1177/2047487320921485
       
  • Impact of smoking on cardiovascular outcomes in patients with stable
           coronary artery disease

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      Authors: Nadia Bouabdallaoui, Nathan Messas, Nicola Greenlaw, Roberto Ferrari, Ian Ford, Kim M Fox, Michal Tendera, Datshana P Naidoo, Christian Hassager, P Gabriel Steg, Jean-Claude Tardif
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-04-28T03:36:26Z
      DOI: 10.1177/2047487320918728
       
  • Acute effect of heat-not-burn versus standard cigarette smoking on
           arterial stiffness and wave reflections in young smokers

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      Authors: Nikolaos Ioakeimidis, Eleni Emmanouil, Dimitrios Terentes-Printzios, Ioanna Dima, Konstantinos Aznaouridis, Dimitris Tousoulis, Charalambos Vlachopoulos
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-04-28T03:36:25Z
      DOI: 10.1177/2047487320918365
       
  • Humans are not meant to live alone

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      Authors: Andreas Hoffmann
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-04-27T04:47:56Z
      DOI: 10.1177/2047487320920757
       
  • Future-proofing cardiac rehabilitation: Transitioning services to
           telehealth during COVID-19

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      Authors: Emma Thomas, Robyn Gallagher, and Sherry L Grace
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-04-23T12:48:05Z
      DOI: 10.1177/2047487320922926
       
  • Achieving post-percutaneous coronary intervention low-density
           lipoprotein-cholesterol goals: Science versus reality

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      Authors: Lale Tokgozoglu, Duygu Kocyigit
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-04-21T03:26:26Z
      DOI: 10.1177/2047487320919867
       
  • Adverse events with sacubitril/valsartan in the real world: emerging
           signals to target preventive strategies from the FDA adverse event
           reporting system

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      Authors: Milo Gatti, Ippazio Cosimo Antonazzo, Igor Diemberger, Fabrizio De Ponti, Emanuel Raschi
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-04-21T03:26:25Z
      DOI: 10.1177/2047487320915663
       
  • Physical activity and cardiovascular risk: No such thing as ‘Too
           little, too late’

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      Authors: Scott T Chiesa, Marietta Charakida
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-04-19T11:29:06Z
      DOI: 10.1177/2047487320920765
       
  • Management of complications of cardiac amyloidosis: 10 questions and
           answers

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      Authors: Alberto Aimo, Claudio Rapezzi, Giuseppe Vergaro, Alberto Giannoni, Valentina Spini, Claudio Passino, Michele Emdin
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-04-17T02:06:28Z
      DOI: 10.1177/2047487320920756
       
  • Amiodarone as a possible therapy for coronavirus infection

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      Authors: Alberto Aimo, Aldo Baritussio, Michele Emdin, Carlo Tascini
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-04-16T07:00:03Z
      DOI: 10.1177/2047487320919233
       
  • Association between estimated pulse wave velocity and the risk of
           cardiovascular outcomes in men

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      Authors: Sae Young Jae, Kevin S Heffernan, Jeong Bae Park, Sudhir Kurl, Setor K Kunutsor, Jang-Young Kim, Jari A Laukkanen
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-04-16T01:59:03Z
      DOI: 10.1177/2047487320920767
       
  • Severe acute respiratory syndrome coronavirus 2 infection,
           angiotensin-converting enzyme 2 and treatment with angiotensin-converting
           enzyme inhibitors or angiotensin II type 1 receptor blockers

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      Authors: Riccardo Sarzani, Federico Giulietti, Chiara Di Pentima, Piero Giordano, Francesco Spannella
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-04-15T07:00:02Z
      DOI: 10.1177/2047487320918421
       
  • Chemoreceptor hyperactivity in heart failure: Is lactate the culprit'

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      Authors: Andrea Segreti, Francesco Grigioni, Jeness Campodonico, Alessandra Magini, Denise Zaffalon, Gianfranco Sinagra, Germano Di Sciascio, Erik Richard Swenson, Piergiuseppe Agostoni
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-04-11T06:20:34Z
      DOI: 10.1177/2047487320915548
       
  • Discordant responses of plasma low-density lipoprotein cholesterol and
           lipoprotein(a) to alirocumab: A pooled analysis from 10 ODYSSEY Phase 3
           studies

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      Authors: Tahir Mahmood, Jessica Minnier, Matthew K Ito, Qian H Li, Andrew Koren, Ivy W Kam, Sergio Fazio, Michael D Shapiro
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-04-11T06:20:33Z
      DOI: 10.1177/2047487320915803
       
  • Bereavement in the year before a first myocardial infarction: Impact on
           prognosis

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      Authors: Dang Wei, Imre Janszky, Rickard Ljung, Karin Leander, Hua Chen, Fang Fang, Jiong Li, Krisztina D László
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-04-11T06:20:33Z
      DOI: 10.1177/2047487320916958
       
  • Long-term cumulative blood pressure in young adults and incident heart
           failure, coronary heart disease, stroke, and cardiovascular disease: The
           CARDIA study

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      Authors: Chike C Nwabuo, Duke Appiah, Henrique T Moreira, Henrique D Vasconcellos, Yuichiro Yano, Jared P Reis, Ravi V Shah, Venkatesh L Murthy, Norrina B Allen, Stephen Sidney, Paul Muntner, Cora E Lewis, Donald M Lloyd-Jones, Pamela J Schreiner, Samuel S Gidding, João AC Lima
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-04-11T06:20:32Z
      DOI: 10.1177/2047487320915342
       
  • Physical activity attenuates cardiovascular risk and mortality in men and
           women with and without the metabolic syndrome – a 20-year follow-up of a
           population-based cohort of 60-year-olds

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      Authors: Elin Ekblom-Bak, Mats Halldin, Max Vikström, Andreas Stenling, Bruna Gigante, Ulf de Faire, Karin Leander, Mai-Lis Hellénius
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-04-11T06:20:32Z
      DOI: 10.1177/2047487320916596
       
  • Non-genetic risk factors for atrial fibrillation are equally important in
           both young and old age: A nationwide population-based study

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      Authors: Yun Gi Kim, Kyung-Do Han, Jong-Il Choi, Yun Young Choi, Ha Young Choi, Ki Yung Boo, Do Young Kim, Kwang-No Lee, Jaemin Shim, Jin-Seok Kim, Yong Gyu Park, Young-Hoon Kim
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-04-11T06:20:31Z
      DOI: 10.1177/2047487320915664
       
  • Rays of light into the ‘black-box’ of exercise hypertension

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      Authors: Birna Bjarnason-Wehrens, Hans-Georg Predel
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-04-11T06:20:29Z
      DOI: 10.1177/2047487320918343
       
  • The results are in: Cardiovascular benefits of glucagon-like peptide-1
           receptor agonists – a trial sequential analysis

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      Authors: Jeffrey Shi Kai Chan
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-04-11T06:20:29Z
      DOI: 10.1177/2047487320918722
       
  • Imaging subclinical atherosclerosis in cardiovascular risk stratification

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      Authors: Michaela Kozakova, Carlo Palombo
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-04-11T06:20:28Z
      DOI: 10.1177/2047487320916589
       
  • After surviving cancer, cardiovascular prevention should not be forgotten

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      Authors: Jakub J Regieli, Marcel ThB Twickler
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-04-11T06:20:28Z
      DOI: 10.1177/2047487320918426
       
  • The Coronary ARteriogenesis with combined Heparin and EXercise therapy in
           chronic refractory Angina (CARHEXA) trial: A double-blind, randomized,
           placebo-controlled stress echocardiographic study

    • Free pre-print version: Loading...

      Authors: Marija T Petrovic, Ana Djordjevic-Dikic, Vojislav Giga, Nikola Boskovic, Vladan Vukcevic, Vladimir Cvetic, Ana Mladenovic, Oliver Radmili, Zeljko Markovic, Milan Dobric, Srdjan Aleksandric, Milorad Tesic, Stefan Juricic, Biljana Nedeljkovic Beleslin, Sinisa Stojkovic, Miodrag C Ostojic, Branko Beleslin, Eugenio Picano
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-04-09T02:07:36Z
      DOI: 10.1177/2047487320915661
       
  • Impact of diesel exposure on human health: the saga
           continues …

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      Authors: Jürgen H Prochaska, Felix Müller, Philipp S Wild
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-04-09T02:07:35Z
      DOI: 10.1177/2047487320915335
       
  • Cardiorespiratory fitness and cancer in men with cardiovascular disease:
           Analysis from the Veterans Exercise Testing Study

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      Authors: Baruch Vainshelboim, Khin Chan, Zhongming Chen, Jonathan Myers
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-04-02T01:33:34Z
      DOI: 10.1177/2047487320916595
       
  • EUROASPIRE V and uncontrolled risk factors in primary prevention:
           Atherosclerotic cardiovascular disease in the making

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      Authors: Raul D Santos
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-04-02T01:33:30Z
      DOI: 10.1177/2047487320915662
       
  • EAPC’s ‘Country of the Month’ prevention web section
           going global

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      Authors: Arne Janssen, Joep Perk, Arno Hoes, Paul Dendale
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-04-02T01:33:29Z
      DOI: 10.1177/2047487320915808
       
  • Cardiovascular complications of obesity during early pregnancy:
           methodological and practical implications

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      Authors: Alex Dregan
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-04-02T01:33:29Z
      DOI: 10.1177/2047487320915809
       
  • PCSK9 inhibitors: Going forward and beyond

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      Authors: Armin Attar
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-04-02T01:33:25Z
      DOI: 10.1177/2047487320916964
       
  • Achievement of European guideline-recommended lipid levels
           post-percutaneous coronary intervention: A population-level observational
           cohort study

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      Authors: Daniel E Harris, Arron Lacey, Ashley Akbari, Fatemeh Torabi, Dave Smith, Geraint Jenkins, Daniel Obaid, Alex Chase, Mike Gravenor, Julian Halcox
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-04-01T01:18:36Z
      DOI: 10.1177/2047487320914115
       
  • Managing refractory angina – is exercise with co-administered
           heparin the solution'

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      Authors: Attila Kardos
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-04-01T01:18:34Z
      DOI: 10.1177/2047487320915346
       
  • Association between ideal cardiovascular health and risk of sudden cardiac
           death and all-cause mortality among middle-aged men in Finland

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      Authors: Nzechukwu M Isiozor, Setor K Kunutsor, Ari Voutilainen, Sudhir Kurl, Jussi Kauhanen, Jari A Laukkanen
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-04-01T01:18:32Z
      DOI: 10.1177/2047487320915338
       
  • Profile and treatment of chronic coronary syndromes in European Society of
           Cardiology member countries: The ESC EORP CICD-LT registry

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      Authors: Michel Komajda, Francesco Cosentino, Roberto Ferrari, Mathieu Kerneis, Elena Kosmachova, Cécile Laroche, Aldo P Maggioni, Harald Rittger, Philippe G Steg, Hanna Szwed, Luigi Tavazzi, Marco Valgimigli, Chris P Gale
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-03-31T07:00:06Z
      DOI: 10.1177/2047487320912491
       
  • We need better data on how to manage myocarditis in athletes

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      Authors: Paul D Thompson, G William Dec
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-03-31T04:23:16Z
      DOI: 10.1177/2047487320915545
       
  • Predicting 10-year mortality in older adults using VO2max, oxygen uptake
           efficiency slope and frailty class

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      Authors: Erik Fung, Leong Ting Lui, Finn Gustafsson, Forrest CF Yau, Jason CS Leung, Petri Wiklund, Marjo-Riitta Järvelin, Peter S Macdonald, Jean Woo
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-03-31T04:23:15Z
      DOI: 10.1177/2047487320914435
       
  • The Moderate Alcohol and Cardiovascular Health Trial: Public health
           advocates should support good science, not undermine it

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      Authors: William DeJong
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-03-31T04:23:15Z
      DOI: 10.1177/2047487320915802
       
  • How research on depression could now fundamentally change preventive
           cardiology

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      Authors: Maximilian Andreas Storz
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-03-31T04:23:15Z
      DOI: 10.1177/2047487320915804
       
  • Exercise cardiac power and the risk of myocardial infarction and fatal
           coronary heart disease events in men

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      Authors: Sudhir Kurl, Sae Young Jae, Timo H Mäkikallio, Magnus J Hagnäs, Jari A Laukkanen
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-03-31T04:23:14Z
      DOI: 10.1177/2047487320914734
       
  • The Admit-AF risk score: A clinical risk score for predicting hospital
           admissions in patients with atrial fibrillation

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      Authors: Pascal Meyre, Stefanie Aeschbacher, Steffen Blum, Michael Coslovsky, Jürg H Beer, Giorgio Moschovitis, Nicolas Rodondi, Oliver Baretella, Richard Kobza, Christian Sticherling, Leo H Bonati, Matthias Schwenkglenks, Michael Kühne, Stefan Osswald, David Conen
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-03-31T04:23:14Z
      DOI: 10.1177/2047487320915350
       
  • Secondary prevention through comprehensive cardiovascular rehabilitation:
           From knowledge to implementation. 2020 update. A position paper from the
           Secondary Prevention and Rehabilitation Section of the European
           Association of Preventive Cardiology

    • Free pre-print version: Loading...

      Authors: Marco Ambrosetti, Ana Abreu, Ugo Corrà, Constantinos H Davos, Dominique Hansen, Ines Frederix, Marie C Iliou, Roberto FE Pedretti, Jean-Paul Schmid, Carlo Vigorito, Heinz Voller, Mathias Wilhelm, Massimo F Piepoli, Birna Bjarnason-Wehrens, Thomas Berger, Alain Cohen-Solal, Veronique Cornelissen, Paul Dendale, Wolfram Doehner, Dan Gaita, Andreas B Gevaert, Hareld Kemps, Nicolle Kraenkel, Jari Laukkanen, Miguel Mendes, Josef Niebauer, Maria Simonenko, Ann-Dorthe Olsen Zwisler
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-03-30T07:00:04Z
      DOI: 10.1177/2047487320913379
       
  • Are statins back for patients on hemodialysis'

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      Authors: Zaid I Almarzooq, Deepak L Bhatt
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-03-30T04:36:02Z
      DOI: 10.1177/2047487320912074
       
  • Cardiac rehabilitation: Challenges and strategies for the day after

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      Authors: Alexandros Stefanidis
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-03-30T04:36:02Z
      DOI: 10.1177/2047487320914098
       
  • Facing a new paradigm: Not retreating but advancing in another direction

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      Authors: Gabriel L de Oliveira Salvador
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-03-26T04:04:50Z
      DOI: 10.1177/2047487320912899
       
  • Women and cardiac rehabilitation: Moving beyond barriers to solutions'

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      Authors: Faye Forsyth, Christi Deaton
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-03-26T04:04:49Z
      DOI: 10.1177/2047487320911843
       
  • Circulating cell-free DNA levels are associated with adverse outcomes in
           heart failure: testing liquid biopsy in heart failure

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      Authors: Andrea Salzano, Muhammad Zubair Israr, Daniel Fernandez Garcia, Laura Middleton, Roberta D’Assante, Alberto M Marra, Michele Arcopinto, Yoshiyuki Yazaki, Dennis Bernieh, Shabana Cassambai, Karen Page, Giuseppe Rengo, Eduardo Bossone, Antonio Cittadini, Jacqueline A Shaw, Toru Suzuki
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-03-26T04:04:48Z
      DOI: 10.1177/2047487320912375
       
  • Physical inactivity after valve surgery is associated with increased
           mortality. Where do we go from here'

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      Authors: Véronique A Cornelissen, Roselien Buys
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-03-26T04:04:48Z
      DOI: 10.1177/2047487320912897
       
  • The determinant effect of competing events in the analysis of heart
           failure incidence after myocardial infarction

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      Authors: Alberto Cordero, Vicente Bertomeu-González, José Ramón González-Juanatey
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-03-26T04:04:48Z
      DOI: 10.1177/2047487320913183
       
  • Subjective assessment of functional capacity to predict postoperative
           myocardial injury and death: Hope or hype'

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      Authors: Leonardo Roever, Tong Liu, Gary Tse, Giuseppe Biondi-Zoccai
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-03-26T04:04:47Z
      DOI: 10.1177/2047487320912624
       
  • ‘Fishing’ for therapies to ‘net’ cost-effective
           benefits

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      Authors: M Wesley Milks
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-03-26T04:04:47Z
      DOI: 10.1177/2047487320913812
       
  • Cardiovascular risk factors in American young adults: The need for general
           population health examination surveys

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      Authors: Susana Sans Menéndez
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-03-26T04:04:46Z
      DOI: 10.1177/2047487320910860
       
  • Socioeconomic disparities in the management of coronary heart disease in
           438 general practices in Australia

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      Authors: George Mnatzaganian, Crystal Man Ying Lee, Suzanne Robinson, Freddy Sitas, Clara K Chow, Mark Woodward, Rachel R Huxley
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-03-26T04:04:45Z
      DOI: 10.1177/2047487320912087
       
  • Short-term prognosis of normalising serum potassium following an episode
           of hypokalaemia in patients with chronic heart failure

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      Authors: Mette Aldahl, Christoffer Polcwiartek, Line Davidsen, Kristian Kragholm, Peter Søgaard, Christian Torp-Pedersen, Maria L Krogager
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.
      Background/aimIt is well known that patients with chronic heart failure and hypokalaemia have increased mortality risk. We investigated the impact of normalising serum potassium following an episode of hypokalaemia on short-term mortality among patients with chronic heart failure.Methods and resultsWe identified 1673 patients diagnosed with chronic heart failure who had a serum potassium measurement under 3.5 mmol/l within 14 days and one year after initiated medical treatment with both loop diuretics and angiotensin-converting enzyme inhibitors or angiotensin-II receptor blockers. A second serum potassium measurement was required 8–30 days after the episode of hypokalaemia. All-cause mortality and cardiovascular mortality was examined within 90 days from the second serum potassium measurement. Mortality was examined according to six predefined potassium groups derived from the second measurement:
      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-03-26T04:04:43Z
      DOI: 10.1177/2047487320911154
       
  • High awareness of diabetes as a key cardiovascular risk factor among
           healthcare professionals but suboptimal treatment: Results from a survey
           of the European Association of Preventive Cardiology

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      Authors: Dominique Hansen, Linda Mellbin, Francesco Cosentino, Dirk De Bacquer, Diederick Grobbee, Lisa Van Ryckeghem, Eberhard Standl, Joline WJ Beulens
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-03-25T02:00:52Z
      DOI: 10.1177/2047487320911845
       
  • Early cardiovascular structural and functional abnormalities as a guide to
           future morbid events

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      Authors: Juhani S Koskinen, Olli T Raitakari
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-03-25T02:00:51Z
      DOI: 10.1177/2047487320908700
       
  • Left ventricular hypertrophy in athletes: How to differentiate between
           hypertensive heart disease and athlete’s heart

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      Authors: Flavio D’Ascenzi, Caterina Fiorentini, Francesca Anselmi, Sergio Mondillo
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-03-25T02:00:50Z
      DOI: 10.1177/2047487320911850
       
  • Hypokalemia in heart failure: A low or a high point'

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      Authors: Jonathan W Cunningham, Mandeep R Mehra
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-03-22T02:25:32Z
      DOI: 10.1177/2047487320914745
       
  • Primary prevention efforts are poorly developed in people at high
           cardiovascular risk: A report from the European Society of Cardiology
           EURObservational Research Programme EUROASPIRE V survey in 16 European
           countries

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      Authors: Kornelia Kotseva, Guy De Backer, Dirk De Bacquer, Lars Rydén, Arno Hoes, Diederick Grobbee, Aldo Maggioni, Pedro Marques-Vidal, Catriona Jennings, Ana Abreu, Carlos Aguiar, Jolita Badariene, Jan Bruthans, Renata Cifkova, Kairat Davletov, Mirza Dilic, Maryna Dolzhenko, Dan Gaita, Nina Gotcheva, Hosam Hasan-Ali, Piotr Jankowski, Christos Lionis, Silvia Mancas, Davor Milićić, Erkin Mirrakhimov, Rafael Oganov, Nana Pogosova, Željko Reiner, Duško Vulić, David Wood
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.
      BackgroundEuropean Action on Secondary and Primary Prevention by Intervention to Reduce Events (EUROASPIRE) V in primary care was carried out by the European Society of Cardiology EURObservational Research Programme in 2016–2018. The main objective was to determine whether the 2016 Joint European Societies’ guidelines on cardiovascular disease prevention in people at high cardiovascular risk have been implemented in clinical practice.MethodsThe method used was a cross-sectional survey in 78 centres from 16 European countries. Patients without a history of atherosclerotic cardiovascular disease either started on blood pressure and/or lipid and/or glucose lowering treatments were identified and interviewed ≥ 6 months after the start of medication.ResultsA total of 3562 medical records were reviewed and 2759 patients (57.6% women; mean age 59.0 ± 11.6 years) interviewed (interview rate 70.0%). The risk factor control was poor with 18.1% of patients being smokers, 43.5% obese (body mass index ≥30 kg/m2) and 63.8% centrally obese (waist circumference ≥88 cm for women, ≥102 cm for men). Of patients on blood pressure lowering medication 47.0% reached the target of
      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-03-20T03:42:32Z
      DOI: 10.1177/2047487320908698
       
  • New perspective on the risk markers for left atrial thrombosis in patients
           with atrial fibrillation

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      Authors: Xuan Zhang, Mengjie Hu, Xiying Wang, Chi Zhang, Wanwan Chen, Songzan Chen, Jintao Zhou, Yuxiao Chen, Lian Lou, Guoping Chen, Fanghong Dong, Shenjiang Hu, Liangrong Zheng, Jian Yang
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-03-19T05:12:32Z
      DOI: 10.1177/2047487320912084
       
  • Is caffeine or coffee consumption a risk for new-onset atrial
           fibrillation' A systematic review and meta-analysis

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      Authors: Chayakrit Krittanawong, Anusith Tunhasiriwet, Zhen Wang, Ann M Farrell, Sakkarin Chirapongsathorn, HongJu Zhang, Takeshi Kitai, Davendra Mehta
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-03-18T08:00:07Z
      DOI: 10.1177/2047487320908385
       
  • Attenuation of peri-vascular fat at computed tomography to measure
           inflammation in ascending aorta aneurysms

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      Authors: Nicola Gaibazzi, Daniele Sartorio, Domenico Tuttolomondo, Fiorenza Napolitano, Carmine Siniscalchi, Bruno Borrello, Anselmo Alessandro Palumbo, Francesco Nicolini
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-03-18T04:32:12Z
      DOI: 10.1177/2047487320911846
       
  • Molecular imaging of active coronary micro-calcification with 18F-NaF and
           PET: emergence of a new biomarker of the vulnerable atherosclerotic
           plaque'

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      Authors: Thomas H Schindler, Brittany Varney, Sudhir Jain
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-03-18T04:32:12Z
      DOI: 10.1177/2047487320912627
       
  • Age- and gender-specific upper limits and reference equations for
           workload-indexed systolic blood pressure response during bicycle ergometry
           

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      Authors: Kristofer Hedman, Thomas Lindow, Viktor Elmberg, Lars Brudin, Magnus Ekström
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.
      BackgroundGuidelines recommend considering workload in interpretation of the systolic blood pressure (SBP) response to exercise, but reference values are lacking.DesignThis was a retrospective, consecutive cohort study.MethodsFrom 12,976 subjects aged 18–85 years who performed a bicycle ergometer exercise test at one centre in Sweden during the years 2005–2016, we excluded those with prevalent cardiovascular disease, comorbidities, cardiac risk factors or medications. We extracted SBP, heart rate and workload (watt) from ≥ 3 time points from each test. The SBP/watt-slope and the SBP/watt-ratio at peak exercise were calculated. Age- and sex-specific mean values, standard deviations and 90th and 95th percentiles were determined. Reference equations for workload-indexed and peak SBP were derived using multiple linear regression analysis, including sex, age, workload, SBP at rest and anthropometric variables as predictors.ResultsA final sample of 3839 healthy subjects (n = 1620 female) were included. While females had lower mean peak SBP than males (188 ± 24 vs 202 ± 22 mmHg, p 
      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-03-10T10:35:18Z
      DOI: 10.1177/2047487320909667
       
  • Lessons learned from community- and home-based physical activity programs:
           A narrative review of factors influencing women’s participation in
           cardiac rehabilitation

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      Authors: Sol Vidal-Almela, Brenna Czajkowski, Stephanie A Prince, Daniele Chirico, Kimberley L Way, Andrew L Pipe, Jennifer L Reed
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.
      BackgroundCardiovascular disease remains a leading cause of death in women. Despite the well-known benefits of cardiac rehabilitation, it remains underutilized, especially among women. Physical activity programs in the community, however, attract a large female population, suggesting that they overcome barriers to physical activity encountered by women. The characteristics of interventions that extend beyond the traditional cardiac rehabilitation model and promote physical activity merit examination.ObjectivesThis narrative review aimed to: (a) summarize women’s barriers to attend cardiac rehabilitation; (b) examine the characteristics of community- and home-based physical activity or lifestyle coaching interventions; and (c) discuss which barriers may be addressed by these alternative programs.MethodsStudies were included if they: (a) were published within the past 10 years; (b) included ≥70% women with a mean age ≥45 years; (c) implemented a community- or home-based physical activity intervention or a lifestyle education/behavioral coaching program; and (d) aimed to improve physical activity levels or physical function.ResultsMost interventions reported high (≥70%) participation rates and significant increases in physical activity levels at follow-up; some improved physical function and/or cardiovascular disease risk factors. Community- and home-based interventions address women’s cardiac rehabilitation barriers by: implementing appealing modes of physical activity (e.g. dancing, group-walking, technology-based balance exercises); adapting the program to meet participants’ needs; offering flexible options regarding timing and setting (e.g. closer to home, the workplace or faith-based institutions); and promoting social interactions.ConclusionCardiac rehabilitation can be enhanced by understanding the specific needs of women; novel elements such as program offerings, convenient settings and opportunities for socialization should be considered when designing cardiac rehabilitation programs.
      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-03-08T12:05:02Z
      DOI: 10.1177/2047487320907748
       
  • Persistence and adherence to antihypertensive drugs in newly treated
           hypertensive patients according to initial prescription

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      Authors: Su-Min Jeong, Shinhye Kim, Dong Wook Shin, Kyungdo Han, Sang Hyun Park, Sang Hyuk Kim, Yul-Hee Kim, Yong-Chol Kwon
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-03-06T08:00:03Z
      DOI: 10.1177/2047487319900326
       
  • How to prevent cardiovascular events from recurring

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      Authors: Katharina Lechner, Clemens von Schacky
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-03-05T05:11:48Z
      DOI: 10.1177/2047487320909943
       
  • Caffeinated coffee consumption and risk of atrial fibrillation in two
           Spanish cohorts

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      Authors: P Bazal, A Gea, AM Navarro, J Salas-Salvadó, D Corella, A Alonso-Gómez, M Fitó, C Muñoz-Bravo, R Estruch, M Fiol, J Lapetra, L Serra-Majem, E Ros, J Rekondo, MA Muñoz, J Basora, JV Sorlí, E Toledo, MA Martínez-González, M Ruiz-Canela
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.
      AimsThe association between caffeinated coffee consumption and atrial fibrillation remains unclear. Recent studies suggest an inverse association only between a moderate caffeinated coffee consumption and atrial fibrillation, but others have reported no association. The aim of our study was to prospectively assess the association between caffeinated coffee consumption and atrial fibrillation in two Spanish cohorts, one of adults from a general population and another of elderly participants at high cardiovascular risk.Methods and resultsWe included 18,983 and 6479 participants from the ‘Seguimiento Universidad de Navarra’ (SUN) and ‘Prevención con Dieta Mediterránea’ (PREDIMED) cohorts, respectively. Participants were classified according to their caffeinated coffee consumption in three groups: ≤3 cups/month, 1–7 cups/week, and>1 cup/day. We identified 97 atrial fibrillation cases after a median follow-up of 10.3 years (interquartile range 6.5–13.5), in the SUN cohort and 250 cases after 4.4 years median follow-up (interquartile range 2.8–5.8) in the PREDIMED study. No significant associations were observed in the SUN cohort although a J-shaped association was suggested. A significant inverse association between the intermediate category of caffeinated coffee consumption (1–7 cups/week) and atrial fibrillation was observed in PREDIMED participants with a multivariable-adjusted hazard ratio = 0.53 (95% confidence interval 0.36–0.79) when compared with participants who did not consume caffeinated coffee or did it only occasionally. No association was found for higher levels of caffeinated coffee consumption (>1 cup per day), hazard ratio = 0.79 (95% confidence interval 0.49–1.28). In the meta-analysis of both PREDIMED and SUN studies, the hazard ratio for intermediate consumption of caffeinated coffee was 0.60 (95% confidence interval 0.44–0.82) without evidence of heterogeneity. Similar findings were found for the association between caffeine intake and atrial fibrillation risk.ConclusionIntermediate levels of caffeinated coffee consumption (1–7 cups/week) were associated with a reduction in atrial fibrillation risk in two prospective Mediterranean cohorts.
      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-03-05T05:11:46Z
      DOI: 10.1177/2047487320909065
       
  • Systematic Coronary Risk Evaluation estimated risk and prevalent
           subclinical atherosclerosis in coronary and carotid arteries: A
           population-based cohort analysis from the Swedish Cardiopulmonary Bioimage
           Study

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      Authors: Carl J Östgren, Stefan Söderberg, Karin Festin, Oskar Angerås, Göran Bergström, Anders Blomberg, John Brandberg, Kerstin Cederlund, Mats Eliasson, Gunnar Engström, David Erlinge, Erika Fagman, Emil Hagström, Lars Lind, Maria Mannila, Ulf Nilsson, Jonas Oldgren, Ellen Ostenfeld, Anders Persson, Jonas Persson, Margaretha Persson, Annika Rosengren, Johan Sundström, Eva Swahn, Jan E Engvall, Tomas Jernberg
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.
      BackgroundIt is not clear if the European Systematic Coronary Risk Evaluation algorithm is useful for identifying prevalent subclinical atherosclerosis in a population of apparently healthy individuals. Our aim was to explore the association between the risk estimates from Systematic Coronary Risk Evaluation and prevalent subclinical atherosclerosis.DesignThe design of this study was as a cross-sectional analysis from a population-based study cohort.MethodsFrom the general population, the Swedish Cardiopulmonary Bioimage Study randomly invited individuals aged 50–64 years and enrolled 13,411 participants mean age 57 (standard deviation 4.3) years; 46% males between November 2013–December 2016. Associations between Systematic Coronary Risk Evaluation risk estimates and coronary artery calcification and plaques in the carotid arteries by using imaging data from a computed tomography of the heart and ultrasonography of the carotid arteries were examined.ResultsCoronary calcification was present in 39.5% and carotid plaque in 56.0%. In men, coronary artery calcium score>0 ranged from 40.7–65.9% and presence of carotid plaques from 54.5% to 72.8% in the age group 50–54 and 60–65 years, respectively. In women, the corresponding difference was from 17.1–38.9% and from 41.0–58.4%. A doubling of Systematic Coronary Risk Evaluation was associated with an increased probability to have coronary artery calcium score>0 (odds ratio: 2.18 (95% confidence interval 2.07–2.30)) and to have>1 carotid plaques (1.67 (1.61–1.74)).ConclusionSystematic Coronary Risk Evaluation estimated risk is associated with prevalent subclinical atherosclerosis in two major vascular beds in a general population sample without established cardiovascular disease or diabetes mellitus. Thus, the Systematic Coronary Risk Evaluation risk chart may be of use for estimating the risk of subclinical atherosclerosis.
      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-03-04T05:22:23Z
      DOI: 10.1177/2047487320909300
       
  • Myocarditis in athletes: A clinical perspective

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      Authors: Martin Halle, Leonhard Binzenhöfer, Heiko Mahrholdt, Michael Johannes Schindler, Katrin Esefeld, Carsten Tschöpe
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.
      Myocarditis is an important cause of arrhythmias and sudden cardiac death (SCD) in both physically active individuals and athletes. Elite athletes seem to have an increased risk for viral infection and subsequent myocarditis due to increased exposure to pathogens (worldwide traveling/international competition) or impaired immune system (continuing training during infections/resuming training early thereafter, strenuous exercise training or competition, and exercising in extreme weather conditions). Initial clinical presentation is variable, but athletes characteristically express non-specific symptoms of fatigue, muscle soreness, increased heart rate at rest, as well as during exercise and reduced overall exercise capacity. Beyond resting electrocardiogram (ECG), cardiac biomarkers, echocardiography, and 24-hour Holter ECG, diagnostic work-up should include cardiac magnetic resonance imaging (CMR) assessing inflammation, oedema, and fibrosis by late gadolinium enhancement (LGE), respectively, as these measures are crucial for prognosis and sports eligibility. For patients with insufficient cardiac recovery, endomyocardial biopsy is recommended to clarify differential diagnoses and initiate specific treatment options. In uncomplicated cases with normal left ventricular function during acute phase and absent LGE, eligibility for sports can be attested to three months after clinical recovery. In those with persistent pathological findings, even after six months, the risk for SCD remains increased and resuming exercise beyond recreational activities can only be recommended individually based on course of disease, left ventricular function, arrhythmias, pattern of LGE in CMR, as well as intensity and volume of exercise performed during training and competition. For all athletes, follow-up examination should be performed yearly.
      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-03-04T05:22:22Z
      DOI: 10.1177/2047487320909670
       
  • Glittre Activities Daily Living Test: Physiological responses in patients
           with heart failure

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      Authors: Miguel P Almeida, Tiago Montanha, Marta Marques, Pedro M Silva, Sofia Viamonte, Fernando Ribeiro, Mário Santos
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-03-04T05:22:22Z
      DOI: 10.1177/2047487320911173
       
  • Efficacy of mobile health cardiovascular risk-reduction strategies in
           cancer survivors

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      Authors: Alexandra C Murphy, Anoop N Koshy, Johanna Mousley, Georgina Meehan, Phelia Kunniardy, David Clark, Leighton Kearney, Belinda Yeo, Omar Farouque, Matias B Yudi
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-03-03T04:48:17Z
      DOI: 10.1177/2047487320907548
       
  • Leisure-time cross-country skiing and the risk of venous thromboembolism:
           A prospective cohort study

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      Authors: Setor K Kunutsor, Timo A Lakka, Sudhir Kurl, Timo H Mäkikallio, Sae Young Jae, Jari A Laukkanen
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-03-03T04:48:17Z
      DOI: 10.1177/2047487320908978
       
  • Underperformance of clinical risk scores in identifying vascular
           

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      Authors: George C Drosos, George Konstantonis, Petros P Sfikakis, Maria G Tektonidou
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.
      AimsThe aim of this study was to assess the performance of eight clinical risk prediction scores to identify individuals with systemic lupus erythematosus (SLE) at high cardiovascular disease (CVD) risk, as defined by the presence of atherosclerotic plaques.MethodsCVD risk was estimated in 210 eligible SLE patients without prior CVD or diabetes mellitus (female: 93.3%, mean age: 44.8 ± 12 years) using five generic (Systematic Coronary Risk Evaluation (SCORE), Framingham Risk Score (FRS), Pooled Cohort Risk Equations (ASCVD), Globorisk, Prospective Cardiovascular Münster Study risk calculator (PROCAM)) and three ‘SLE-adapted’ (modified-SCORE, modified-FRS, QRESEARCH risk estimator, version 3 (QRISK3)) CVD risk scores, as well as ultrasound examination of the carotid and femoral arteries. Calibration, discrimination and classification measures to identify high CVD risk based on the presence of atherosclerotic plaques were assessed for all risk models. CVD risk reclassification was applied for all scores by incorporating ultrasound results.ResultsModerate calibration (p-value range from 0.38 to 0.63) and discrimination (area under the curve 0.73–0.84), and low-to-moderate sensitivity (8.3–71.4%) and classification ability (Matthews correlation coefficient (MCC) 0.25–0.47) were observed for all risk models to identify patients with plaques at any arterial site as high-risk. MCC was improved for modified-FRS versus FRS (0.43 vs 0.36), but not for modified-SCORE versus SCORE (0.25 vs 0.25). Based on plaque presence, CVD risk was upgraded to high-risk in 10%, 16.1%, 20.5%, 21.5%, 24%, 28.2% and 28.6% of cases classified as non-high-risk by QRISK3, modified-FRS, Globorisk, FRS/PROCAM, ASCVD, modified-SCORE and SCORE, respectively.ConclusionsMost of the five generic and three ‘SLE-adapted’ clinical risk scores underestimated high CVD risk defined by atherosclerotic plaque presence in patients with SLE.
      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-03-03T04:48:16Z
      DOI: 10.1177/2047487320906650
       
  • Acute effects of high-intensity interval training and moderate-intensity
           continuous training on arterial stiffness in young obese women

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      Authors: Karin Hortmann, Pierre Boutouyrie, João C Locatelli, Gustavo H de Oliveira, Caroline F Simões, Victor H de Souza Mendes, Higor B Reck, Rogério TP Okawa, Wendell A Lopes
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-03-03T04:48:15Z
      DOI: 10.1177/2047487320909302
       
  • How to remedy the heterogeneity of exercise prescription for
           cardiovascular disease patients

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      Authors: Wei-guang Li, Pei-liang Liu, Xin-an Zhang
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-03-03T04:48:13Z
      DOI: 10.1177/2047487320908077
       
  • One step behind – although incidence decreases, mortality in patients
           with lower-extremity arterial disease (LEAD) lags behind cardiovascular
           disease

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      Authors: Jean-Paul Schmid
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-03-03T04:48:13Z
      DOI: 10.1177/2047487320910292
       
  • Obesity, overweight and risk for cardiovascular disease and mortality in
           young women

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      Authors: Pigi Dikaiou, Lena Björck, Martin Adiels, Christina E Lundberg, Zacharias Mandalenakis, Karin Manhem, Annika Rosengren
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.
      AimsThe aim of this study was to investigate the relation between body mass index (BMI) in young women, using weight early in pregnancy as a proxy for pre-pregnancy weight, and risk for early cardiovascular disease (CVD) and mortality.Methods and resultsIn this prospective, registry-based study, we used weight data in early pregnancy from women, registered in the Swedish Medical Birth Registry, and who gave birth between 1982 and 2014 (n = 1,495,499; median age 28.3 years). Of the women, 118,212 (7.9%) were obese (BMI ≥ 30 kg/m2) and 29,630 (2.0%) severely obese (BMI ≥ 35 kg/m2). After a follow-up of median 16.3 years, we identified 3295 and 4375 cases of acute myocardial infarction (AMI) and ischemic stroke (IS) corresponding to 13.4 and 17.8 per 100,000 observation years, respectively, occurring at mean ages of 49.8 and 47.3 years. Compared to women with a BMI 20–
      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-03-03T04:48:11Z
      DOI: 10.1177/2047487320908983
       
  • Increased awareness, inadequate treatment, and poor control of
           cardiovascular risk factors in American young adults: 2005–2016

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      Authors: Rajat Kalra, Vibhu Parcha, Nirav Patel, Anirudh Bhargava, Katherine S Booker, Garima Arora, Pankaj Arora
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.
      IntroductionThere are little contemporary data about cardiovascular risk factors among young adults. We defined trends in diabetes mellitus (DM), hypertension, and hypercholesterolemia in American adults aged 18–44 years.MethodsThe National Health and Nutrition Examination Study serial cross-sectional surveys were used to define three time periods: 2005–2008, 2009–2012, and 2013–2016. Age-adjusted weighted trends of prevalence, awareness, treatment, and control of DM, hypertension, and hypercholesterolemia were calculated by linear regression modelling in the overall sample, males, and females. Trends were calculated after adjustment for age, race, body mass index, smoking status, education attainment, income, insurance status, and number of healthcare visits.ResultsFrom 2005–2008 to 2013–2016, 15,171 participants were identified. DM prevalence was stable ∼3%, hypertension prevalence was stable ∼11.0%, and hypercholesterolemia prevalence declined from 11.5% to 9.0% (ptrend = 0.02). DM awareness stayed stable between 61.1 and 74.1%, hypertension awareness increased from 68.7 to 77.7% (ptrend = 0.05), and hypercholesterolemia awareness was stable between 46.8 and 54.1%. DM and hypertension treatment improved markedly (ptrend 
      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-03-03T04:48:09Z
      DOI: 10.1177/2047487320905190
       
  • Locking and loading the bullet against micro-calcification

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      Authors: Alexandru Florea, Agnieszka Morgenroth, Jan Bucerius, Leon J Schurgers, Felix M Mottaghy
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.
      AimsDespite recent medical advances, cardiovascular disease remains the leading cause of death worldwide. As (micro)-calcification is a hallmark of atherosclerosis, this review will elaborately discuss advantages of sodium fluoride positron emission tomography (PET) as a reliable cardiovascular imaging technique for identifying the early onset of vascular calcification (i.e. locking onto the target). We assess state-of-the-art meta-analysis and clinical studies of possible treatment options and evaluate the concept of vitamin K supplementation to preserve vascular health (i.e. loading the bullet).Methods and resultsAfter a structured PubMed search, we identified 18F-sodium fluoride (18F-NaF) PET as the most suitable technique for detecting micro-calcification. Presenting the pros and cons of available treatments, vitamin K supplementation should be considered as a possible safe and cost-effective option to inhibit vascular (micro)-calcification.ConclusionThis review demonstrates need for more extensive research in the concept of vitamin K supplementation (i.e. loading the bullet) and recommends monitoring the effects on vascular calcification using 18F-NaF PET (i.e. locking onto the target).
      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-03-03T04:48:09Z
      DOI: 10.1177/2047487320911138
       
  • Association of adherence to antiretroviral therapy with economic burden of
           cardiovascular disease in HIV-infected population

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      Authors: Chia-Te Liao, Chun-Ting Yang, Pin-Hao Chen, Han Siong Toh, Shihchen Kuo, Zhih-Cherng Chen, Huang-Tz Ou, Nai-Ying Ko, Jung-Der Wang
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.
      AimsThere is a lack of studies that rigorously and systematically assess the economic burden of cardiovascular diseases (CVDs) related to the use of antiretroviral therapy (ART). We aimed to assess the association between adherence to ART and economic burden of CVDs in an HIV-infected population.MethodsTaiwan's National Health Insurance Research Database 2000–2011 was utilized for analyzing 18,071 HIV-infected patients free of CVDs before HIV diagnosis. The level of adherence to ART was measured by the medication possession ratio (MPR). Generalized estimating equations analysis was applied to estimate the cost impact of a variety of CVDs. All costs were presented in 2018 US dollars.ResultsThe incidence of CVDs ranged from 0.17/1000 person-years (cardiogenic shock) to 2.60/1000 person-years (ischemic heart diseases (IHDs)). The mean annual medical cost for a base-case patient without CVDs was US$3000. Having cerebrovascular diseases, myocardial infarction, heart failure, arrhythmia, and IHDs increased annual costs by 41%, 33%, 30%, 16%, and 14%, respectively. The cost impact of incident CVDs in years with high adherence to ART (MPR ≥ 0.8) was significantly lower than that in years with low adherence (MPR 
      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-03-03T04:48:08Z
      DOI: 10.1177/2047487320908085
       
  • The association between rotating night shift work and hypertension: A
           cross-sectional study among male workers

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      Authors: Masoud Khosravipour, Mostafa Shah Mohammadi, Hossein Valadi Athar, Iraj Jamebozorgi, Payam Khanlari, Faramarz Gharagozlou
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-02-24T12:13:35Z
      DOI: 10.1177/2047487320906921
       
  • Medication persistence and adherence: A key approach to improve
           hypertension management

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      Authors: Hyoung-Won Cho, Si-Hyuck Kang, Cheol-Ho Kim
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-02-24T12:13:34Z
      DOI: 10.1177/2047487320905191
       
  • Association of smoking with coronary artery disease and myocardial
           infarction: A Mendelian randomization study

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      Authors: Yunlong Lu, Zhen Wang, Liangrong Zheng
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-02-24T05:12:51Z
      DOI: 10.1177/2047487320907747
       
  • Status of dyslipidemia management and statin undertreatment in Korean
           cancer survivors: A Korean National Health and Nutrition Examination
           Survey study

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      Authors: Sujeong Shin, Dong Wook Shin, In Young Cho, Su-Min Jeong, Hyein Jung
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.
      AimsDue to improving cancer treatment results, non-cancer mortality is an important issue for cancer survivors. Cardiovascular diseases are the leading causes of death in Korea and globally. In addition to lowering the risk of cardiovascular disease, the use of statins has led to an overall reduction in cancer mortality in recent observational studies. We investigated the status of current dyslipidemia management in cancer survivors with reference to 2018 guidelines.MethodsThe study is a cross-sectional analysis of 1460 cancer survivors aged from 40 to 75 years who participated in the Korean National Health and Nutrition Examination Survey from 2007 to 2016. Dyslipidemia management status among cancer survivors was assessed according to 2018 American College of Cardiology/American Heart Association guidelines and Korean Coronary Heart Disease Risk Score guidelines.ResultsThe rate of treatment for dyslipidemia was 8.5% for males, 13.8% for females, and 11.9% overall. Among cancer survivors who were not receiving treatment for dyslipidemia, 59.6% of males, 34.2% of females and 43.9% of total cancer survivors would have been eligible for statin therapy under the 2018 American College of Cardiology/American Heart Association guidelines and Korean Coronary Heart Disease Risk Score guidelines. The rate of undertreatment of dyslipidemia increased with age and length of time since cancer diagnosis.ConclusionNearly 50% of cancer survivors remain untreated although they are eligible for statin therapy. This emphasizes the need for more attention to prevent atherosclerotic cardiovascular disease among cancer survivors.
      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-02-24T05:12:50Z
      DOI: 10.1177/2047487320905722
       
  • The management of heterozygous familial hypercholesterolaemia with high
           lipoprotein (a) and statin intolerance. The guidelines a mirage'

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      Authors: Beatrice Dal Pino, Federico Bigazzi, Francesco Sbrana, Tiziana Sampietro
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-02-24T05:12:50Z
      DOI: 10.1177/2047487320905727
       
  • A scoring system for predicting individual treatment effects of statins in
           type 2 diabetes patients on haemodialysis

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      Authors: Bernd Genser, Christoph Wanner, Winfried März
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.
      AimsHaemodialysis patients have high cardiovascular disease risk. Although statins reduce this risk in chronic kidney disease, randomised trials in haemodialysis patients show no benefit. Post-hoc analyses of the German Diabetes Dialysis (4D) study identified patient-specific markers associated with heterogeneous treatment effects. We combined these markers to develop a score for predicting individual effects of statins in these patients.Methods and resultsWe used data from the 4D study, enrolling 1255 haemodialysis patients with type 2 diabetes mellitus, randomised to atorvastatin or placebo and followed for a composite cardiovascular endpoint. We calculated two scores: score 1 based on all 23 predictive markers and score 2 based on 17 clinically accessible markers. Groups stratified by score 1 showed differential treatment effects: for score 31 (466 patients; 38%), it was 0.43 (0.30–0.60), suggesting a benefit. Statins also significantly reduced all-cause mortality in the benefit group. Stratification by score 2 yielded similar results but a smaller group gaining benefit (360 patients).ConclusionStatin effects in haemodialysis patients can be predicted by markers associated with plausible relevant mechanisms including cholesterol metabolism, atherosclerosis, protein energy wasting, or competing risks. In clinical practice, the score could aid in risk stratification, not only to select patients who benefit from statins but also to identify those whom treatment could harm.
      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-02-24T05:12:49Z
      DOI: 10.1177/2047487320905721
       
  • Comparison of Swiss and European risk algorithms for cardiovascular
           prevention in Switzerland

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      Authors: Hadrien Beuret, Nadine Hausler, David Nanchen, Marie Méan, Pedro Marques-Vidal, Julien Vaucher
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.
      BackgroundIn Switzerland, two distinct algorithms are recommended for cardiovascular prevention: (a) Arbeitsgruppe Lipide und Atherosklerose (AGLA); and (b) European Society of Cardiology (ESC). We validated and determined which algorithm better predicts incident atherosclerotic cardiovascular disease and assessed statin eligibility in Switzerland.DesignA prospective population-based cohort.MethodsWe employed longitudinal data of the CoLaus study involving 6733 individuals, aged 35–75 years, with a 10-year follow-up. Using discrimination and calibration, we evaluated the predictive performance of the AGLA and ESC algorithms for the prediction of atherosclerotic cardiovascular disease.ResultsFrom the 6733 initial participants, 5529 were analysed with complete baseline and follow-up data. Mean age (SD) was 52.4 (10.6) years and 54% were women. During an average follow-up (SD) of 10.2 years (1.7), 370 (6.7%) participants developed an incident atherosclerotic cardiovascular disease. The sensitivity of AGLA and ESC algorithms to predict atherosclerotic cardiovascular disease was 51.6% (95% confidence interval (CI) 46.4–56.8) and 58.6% (53.4–63.7), respectively. Discrimination and calibration were similar between the AGLA and ESC algorithms, with area under the receiver operating characteristic curve values of 0.78 (95% CI 0.76–0.80) and 0.79 (0.76–0.81), and Brier scores of 0.059 and 0.041, respectively. Among 370 individuals developing incident atherosclerotic cardiovascular disease, only 278 (75%) were eligible for statin therapy at baseline, including 210 (57%) according to both algorithms, 4 (1%) to AGLA only and 64 (17%) to ESC only.ConclusionAGLA and ESC algorithms presented similar accuracy to predict atherosclerotic cardiovascular disease in Switzerland. A quarter of adults developing atherosclerotic cardiovascular disease were not identified by preventive algorithms to be eligible for statin therapy.
      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-02-24T05:12:47Z
      DOI: 10.1177/2047487320906305
       
  • Fitness for Richer, for Poorer

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      Authors: Peter Kokkinos, Jonathan Myers
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-02-19T05:04:28Z
      DOI: 10.1177/2047487320905024
       
  • High prevalence of physical inactivity after heart valve surgery and its
           association with long-term mortality: A nationwide cohort study

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      Authors: Sun-Hyung Kim, Seungwoo Cha, Seongmin Kang, Kyungdo Han, Nam-Jong Paik, Won-Seok Kim
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.
      AimsPhysical activity (PA) and systematic efforts, such as cardiac rehabilitation, are recommended by several national guidelines for those who have received heart valve surgery. However, only a few studies have demonstrated real-world situations, such as changes in the PA level after heart valve surgery, and their effects on long-term outcomes. We designed this study to investigate the changes in PA after heart valve surgery and their associations with mortality using nationwide representative data.MethodsThis study was performed using the Korean National Health Insurance Service database. We included patients who received heart valve surgery from 2009 to 2015 and underwent regular health checkups before and after surgery. Subjects were grouped according to their PA level before and after the surgery. Information on all-cause mortality was obtained until 31 December 2016, with a maximum follow-up period of 5 years.ResultsOf the 6587 subjects, 3258 (49.5%) were physically inactive after surgery. Among patients who were physically active (n = 3070), 1196 (39.0%) became inactive after surgery. The postoperative ‘inactive’ group showed higher mortality than the ‘active’ group (hazard ratio (HR): 1.41, 95% confidence interval (CI): 1.08–1.83). The ‘inactive/inactive’ group showed the highest risk of mortality (HR: 1.69, 95% CI: 1.19–2.40) compared with the ‘active/active’ group.ConclusionsInsufficient PA level after heart valve surgery is associated with higher risk of mortality. However, maintaining sufficient PA after heart valve surgery may be challenging for many patients. Therefore, systematic efforts, such as cardiac rehabilitation, should be considered in those who received heart valve surgery.
      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-02-13T01:43:11Z
      DOI: 10.1177/2047487320903877
       
  • On the use of models to estimate the total risk of developing
           atherosclerotic cardiovascular disease

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      Authors: Guy G De Backer
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-02-13T01:43:10Z
      DOI: 10.1177/2047487320902747
       
  • Risk scores, atherosclerotic cardiovascular disease and the crystal ball

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      Authors: Pier Luigi Temporelli
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-02-13T01:43:10Z
      DOI: 10.1177/2047487320903157
       
  • Atrial fibrillation and obesity: Long-term incidence and outcomes after
           bariatric surgery

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      Authors: Osama Moussa, Maddalena Ardissino, Christian Eichhorn, Rohin K Reddy, Omar Khan, Paul Ziprin, Ara Darzi, Peter Collins, Sanjay Purkayastha
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-02-12T04:51:36Z
      DOI: 10.1177/2047487320904515
       
  • Editorial: From MACH15 to MACH0 – a missed opportunity to understand the
           health effects of moderate alcohol intake

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      Authors: Lindsay M Miller, Cheryl AM Anderson, Joachim H Ix
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-02-12T04:51:35Z
      DOI: 10.1177/2047487320904230
       
  • Novel prediction equation for appendicular skeletal muscle mass estimation
           in patients with heart failure: Potential application in daily clinical
           practice

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      Authors: Satoshi Katano, Toshiyuki Yano, Katsuhiko Ohori, Nobutaka Nagano, Suguru Honma, Kanako Shimomura, Tomoyuki Ishigo, Ayako Watanabe, Remi Honma, Takefumi Fujito, Masayuki Koyama, Hidemichi Kouzu, Akiyoshi Hashimoto, Masaki Katayose, Tetsuji Miura
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-02-12T04:51:35Z
      DOI: 10.1177/2047487320904236
       
  • Prevalence and risk factors associated with stroke in China: A nationwide
           survey of 726,451 adults

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      Authors: Yong Gan, Heng Jiang, Robin Room, Yiqiang Zhan, Liqing Li, Kai Lu, Chao Wang, Shanquan Chen, Jianxin Liu, Yudi Yang, Hongbin Xu, Zhiqiang Nie, Yuanyuan Chang, Changan Gong, Shuran Tan, Wei Hu, Wei Yue, Feng Yan, Zhihong Wang, Zuxun Lu
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-02-12T04:51:34Z
      DOI: 10.1177/2047487320902324
       
  • Why do we keep asking, do we still need cardiac rehabilitation'

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      Authors: Scott A Lear, Susie Cartledge
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-02-12T04:51:34Z
      DOI: 10.1177/2047487320902745
       
  • Association of short-term exposure to air pollution with myocardial
           infarction with and without obstructive coronary artery disease

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      Authors: Masanobu Ishii, Tomotsugu Seki, Koichi Kaikita, Kenji Sakamoto, Michikazu Nakai, Yoko Sumita, Kunihiro Nishimura, Yoshihiro Miyamoto, Teruo Noguchi, Satoshi Yasuda, Koshiro Kanaoka, Satoshi Terasaki, Yoshihiko Saito, Hiroyuki Tsutsui, Issei Komuro, Hisao Ogawa, Kenichi Tsujita, Koji Kawakami
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.
      BackgroundAir pollution including particulate matter with an aerodynamic diameter ≤2.5 µm (PM2.5) increases the risk of acute myocardial infarction. However, whether short-term exposure to PM2.5 triggers the onset of myocardial infarction with nonobstructive coronary arteries, compared with myocardial infarction with coronary artery disease, has not been elucidated. This study aimed to estimate the association between short-term exposure to PM2.5 and admission for acute myocardial infarction, myocardial infarction with coronary artery disease, and myocardial infarction with nonobstructive coronary arteries.DesignThis was a time-stratified case-crossover study and multicenter validation study.MethodsThis study used a nationwide administrative database in Japan between April 2012–March 2016. Of 137,678 acute myocardial infarction cases, 123,633 myocardial infarction with coronary artery disease and 14,045 myocardial infarction with nonobstructive coronary arteries were identified by a validated algorithm combined with International Classification of Disease (10th revision), diagnostic, and procedure codes. Air pollutants and meteorological data were obtained from the monitoring station nearest to the admitting hospital.ResultsIn spring (March–May), the short-term increase of 10 µg/m3 in PM2.5 2 days before admission was significantly associated with admission for acute myocardial infarction, myocardial infarction with nonobstructive coronary arteries, and myocardial infarction with coronary artery disease after adjustment for meteorological variables (odds ratio 1.060, 95% confidence interval 1.038–1.082; odds ratio 1.151, 1.079–1.227; odds ratio 1.049, 1.026–1.073, respectively), while the association was not significant in other variables. These associations were also observed after adjustment for other co-pollutants. The risk for myocardial infarction with nonobstructive coronary arteries (vs myocardial infarction with coronary artery disease) was associated with an even lower concentration of PM2.5 under the current environmental standards.ConclusionsThis study showed the seasonal difference of acute myocardial infarction risk attributable to PM2.5 and the difference in the threshold of triggering the onset of acute myocardial infarction subtype.
      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-02-12T04:51:33Z
      DOI: 10.1177/2047487320904641
       
  • Added value of subjective assessed functional capacity before non-cardiac
           surgery in predicting postoperative myocardial injury

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      Authors: Marije Marsman, Judith AR van Waes, Remco B Grobben, Corien SA Weersink, Wilton A van Klei
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.
      BackgroundFunctional capacity is used as an indicator for cardiac testing before non-cardiac surgery and is often performed subjectively. However, the value of subjectively estimated functional capacity in predicting cardiac complications is under debate. We determined the predictive value of subjectively assessed functional capacity on postoperative cardiac complications and mortality.DesignAn observational cohort study in patients aged 60 years and over undergoing elective inpatient non-cardiac surgery in a tertiary referral hospital.MethodsSubjective functional capacity was determined by anaesthesiologists. The primary outcome was postoperative myocardial injury. Secondary outcomes were postoperative inhospital myocardial infarction and one year mortality. Logistic regression analysis and area under the receiver operating curves were used to determine the added value of functional capacity.ResultsA total of 4879 patients was included; 824 (17%) patients had a poor subjective functional capacity. Postoperative myocardial injury occurred in 718 patients (15%). Poor functional capacity was associated with myocardial injury (relative risk (RR) 1.7, 95% confidence interval (CI) 1.5–2.0; P 
      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-02-12T04:51:32Z
      DOI: 10.1177/2047487320906918
       
  • Risk of atherosclerotic cardiovascular disease by cardiovascular health
           metric categories in approximately 1 million patients

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      Authors: Jamal S Rana, Jennifer Y Liu, Howard H Moffet, Andrew J Karter, Khurram Nasir, Matthew D Solomon, Marc G Jaffe, Andrew P Ambrosy, Alan S Go, Stephen Sidney
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-02-10T04:00:01Z
      DOI: 10.1177/2047487320905025
       
  • Energy-adjusted Dietary Inflammatory Index scores predict long-term
           cardiovascular disease mortality and other causes of death in an
           ecological analysis of the Seven Countries Study

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      Authors: Paolo E Puddu, Nitin Shivappa, Alessandro Menotti, James R Hébert, Hanna Tolonen, Anthony Kafatos, Hisashi Adachi
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.
      Using data from the Seven Countries Study of Cardiovascular Diseases, the first study to conduct international comparisons of men in different European, USA, and Japanese cohorts, we examined the effect of diet-associated inflammation on prediction of coronary heart disease-, other major cardiovascular disease- and all-cause mortality after 50-years of follow-up. The energy-adjusted Dietary Inflammatory Index was used to quantify the effect of diet on systemic inflammation. Positive linear correlations were observed between the cohort-average energy-adjusted Dietary Inflammatory Index score and both overall death rates (R = 0.61, p = 0.0114) and major cardiovascular disease mortality rates (R = 0.51, p = 0.0337) but not cancer. Correlations for all-cause mortality were higher when the Belgrade outlier cohort was omitted (R = 0.72, p = 0.0024) or when analyses were adjusted for socioeconomic status (R = 0.67, p = 0.0065). There was also a significant reverse correlation between energy-adjusted Dietary Inflammatory Index score and age at death (R = –0.50 to –0.68, p = 0.0480 to 0.0012). Adjusting for systolic blood pressure, cholesterol, and smoking habits did not modify these correlations that were still significant. With control for these covariates a significant correlation emerged for coronary heart disease. Results obtained using a 25-year follow-up to allow unprojected data from all cohorts were similar. Results from this long-term follow-up study are consistent with a recommendation to increase consuming an anti-inflammatory diet characterized by high concentrations of fruits and vegetables and low consumption of simple carbohydrates and fats.
      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-02-05T05:49:22Z
      DOI: 10.1177/2047487320903866
       
  • LDL-cholesterol lowering with evolocumab, and outcomes according to age
           and sex in patients in the FOURIER Trial

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      Authors: Peter Sever, Ioanna Gouni-Berthold, Anthony Keech, Robert Giugliano, Terje R Pedersen, KyungAh Im, Huei Wang, Beat Knusel, Marc S Sabatine, Michelle L O’Donoghue
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.
      AimsSome trials have reported diminished efficacy for statins in the elderly, and in women compared with men. We examined the efficacy and safety of evolocumab by patient age and sex in the FOURIER trial, the first major cardiovascular outcome trial of a PCSK9 inhibitor.Methods and resultsFOURIER was a randomised, double blind trial, comparing evolocumab with placebo in 27,564 patients with atherosclerotic cardiovascular disease receiving statin therapy (median follow-up 2.2 years). The primary endpoint was cardiovascular death, myocardial infarction, stroke, hospitalisation for unstable angina or coronary revascularisation. Cox proportional hazards models were used to assess the efficacy of evolocumab versus placebo stratified by quartiles of patient age and by sex. There were small variations in the cardiovascular event rate across the age range (for the primary endpoint, Kaplan–Meier at 3 years 15.6%,>69 years, vs. 15.1%, ≤56 years, P = 0.45); however, the relative efficacy of evolocumab was consistent regardless of patient age (for the primary endpoint (Q1 hazard ratio, 95% confidence interval) 0.83, 0.72–0.96, Q2 0.88, 0.76–1.01, Q3 0.82, 0.71–0.95, Q4 0.86, 0.74–1.00; Pinteraction = 0.91), and the key secondary endpoint (cardiovascular death, myocardial infarction, stroke) (Q1 0.74 (0.61–0.89), Q2 0.83 (0.69–1.00), Q3 0.78 (0.65–0.94), Q4 0.82 (0.69–0.98)); Pinteraction = 0.81). Women had a lower primary endpoint rate than men (Kaplan–Meier at 3 years 12.5 vs. 15.3%, respectively, P 
      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-02-05T05:49:21Z
      DOI: 10.1177/2047487320902750
       
  • New risk prediction models in England may lead to targeted PCSK9 inhibitor
           treatment, for patients with established cardiovascular disease

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      Authors: Taavi Tillmann
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-02-05T05:49:21Z
      DOI: 10.1177/2047487320904513
       
  • Early cardiovascular structural and functional abnormalities as a guide to
           future morbid events

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      Authors: Daniel A Duprez, Sue Duval, Lynn Hoke, Natalia Florea, Gregory Grandits, Claire Carlson, Joy Lee, Jay N Cohn
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.
      AimsOur aim was to evaluate the predictive value of a battery of 10 non-invasive tests of cardiovascular structural and functional health on the future risk of cardiovascular morbid events.Methods and ResultsA total of 1900 asymptomatic adults concerned about their risk for cardiovascular disease underwent non-invasive assessment with 10 tests of vascular and cardiac structure and function. A disease score (DS) was calculated for each individual based on these 10 tests. Follow-up (mean 9.2 years) for cardiovascular morbidity and mortality was available for 1442 individuals (mean age 53.2 years, 48.2% women). Those in the lowest DS tertile (0–2) experienced 0.16 cardiovascular events per 100 patient-years (PY), those in the middle tertile (3–5) experienced 0.86 events per 100 PY, and those in the highest tertile (6+) experienced 1.3 events per 100 PY (p 
      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-02-05T05:49:19Z
      DOI: 10.1177/2047487320901416
       
  • The pre-HFpEF stage: a new entity that requires proper phenotyping for
           better management

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      Authors: Antoni Bayes-Genis, Domingo Pascual-Figal, Julio Núñez
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-02-05T05:49:19Z
      DOI: 10.1177/2047487320902326
       
  • Response to statin therapy in the real world

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      Authors: Armin Attar
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-02-05T05:49:18Z
      DOI: 10.1177/2047487320905718
       
  • Impact of cardiorespiratory fitness on survival in men with low
           socioeconomic status

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      Authors: Sae Young Jae, Sudhir Kurl, Kanokwan Bunsawat, Barry A Franklin, Jina Choo, Setor K Kunutsor, Jussi Kauhanen, Jari A Laukkanen
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.
      AimsAlthough both low socioeconomic status (SES) and poor cardiorespiratory fitness (CRF) are associated with increased chronic disease and heightened mortality, it remains unclear whether moderate-to-high levels of CRF are associated with survival benefits in low SES populations. This study evaluated the hypothesis that SES and CRF predict all-cause mortality and cardiovascular disease mortality and that moderate-to-high levels of CRF may attenuate the association between low SES and increased mortality.MethodsThis study included 2368 men, who were followed in the Kuopio Ischaemic Heart Disease Study cohort. CRF was directly measured by peak oxygen uptake during progressive exercise testing. SES was characterized using self-reported questionnaires.ResultsDuring a 25-year median follow-up, 1116 all-cause mortality and 512 cardiovascular disease mortality events occurred. After adjusting for potential confounders, men with low SES were at increased risks for all-cause mortality (hazard ratio 1.49, 95% confidence interval: 1.30–1.71) and cardiovascular disease mortality (hazard ratio1.38, 1.13–1.69). Higher levels of CRF were associated with lower risks of all-cause mortality (hazard ratio 0.54, 0.45–0.64) and cardiovascular disease mortality (hazard ratio 0.53, 0.40–0.69). In joint associations of SES and CRF with mortality, low SES-unfit had significantly higher risks of all-cause mortality (hazard ratio 2.15, 1.78–2.59) and cardiovascular disease mortality (hazard ratio 1.95, 1.48-2.57), but low SES-fit was not associated with a heightened risk of cardiovascular disease mortality (hazard ratio 1.09, 0.80-1.48) as compared with their high SES-fit counterparts.ConclusionBoth SES and CRF were independently associated with subsequent mortality; however, moderate-to-high levels of CRF were not associated with an excess risk of cardiovascular disease mortality in men with low SES.
      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-02-04T04:45:03Z
      DOI: 10.1177/2047487319901057
       
  • Cardiovascular event rates increase after each recurrence and associate
           with poor statin adherence

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      Authors: Mariann I Lassenius, Iiro Toppila, Susanne Bergius, Julia Perttilä, KE Juhani Airaksinen, Mikko Pietilä
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.
      AimsThe study evaluated the quality of cardiovascular prevention in real-world clinical practice. The recurrence of up to five cardiovascular events was assessed, as data on recurrence beyond the first event and interindividual variations in event rates past the second event have been sparse. Low-density lipoprotein cholesterol concentrations and lipid-lowering therapy use were investigated.MethodsThis retrospective register-based study included adult patients with an incident cardiovascular event between 2004 and 2016 treated in the hospital district of southwest Finland. Patients were followed for consecutive cardiovascular events or cardiovascular death, low-density lipoprotein cholesterol and statin purchases. The timing of event recurrence was evaluated, and predictive factors were assessed.ResultsA wide interindividual variation in cardiovascular event recurrence was observed, each additional event caused an increased risk, the median time of recurrence decreased from 7 to one year for the second and fifth event. Event rates increased correspondingly from 12 to 43/100 patient-years and were most pronounced in the first years following the previous event. The low-density lipoprotein cholesterol goal (
      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-02-04T04:45:02Z
      DOI: 10.1177/2047487320904334
       
  • Integrating natriuretic peptides and diastolic dysfunction to predict
           adverse events in high-risk asymptomatic subjects

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      Authors: Mauro Gori, Carolyn SP Lam, Emila D’Elia, Anna M Iorio, Alice Calabrese, Paolo Canova, Giovanni Cioffi, Renata De Maria, Arianna Ghirardi, Attilio Iacovoni, Aurelia Grosu, Alessandra Fontana, Paola Ferrari, Gianfranco Parati, Antonello Gavazzi, Michele Senni
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.
      BackgroundNatriuretic peptides and diastolic dysfunction have prognostic value in asymptomatic subjects at risk for heart failure. Their integration might further refine the risk stratification process in this setting. Aim of this paper was to explore the possibility to predict heart failure and death combining diastolic dysfunction and natriuretic peptides in an asymptomatic population at risk for heart failure.MethodsAmong 4047 subjects aged ≥55/≤80 years followed by 10 general practitioners in Italy, the DAVID-Berg study prospectively enrolled 623 asymptomatic outpatients at increased risk for heart failure. Baseline evaluation included electrocardiogram, echocardiogram, and natriuretic peptides collection. Based on diastolic dysfunction and natriuretic peptides, subjects were classified in four groups: control group (no diastolic dysfunction/normal natriuretic peptides, 57%), no diastolic dysfunction/high natriuretic peptides (9%), diastolic dysfunction/normal natriuretic peptides (24%), and diastolic dysfunction/high natriuretic peptides (11%). We applied Cox multivariable and Classification and Regression Tree analyses.ResultsThe mean age of the population was 69 ± 7 years, 44% were women, mean left ventricular ejection fraction was 61%, and 35% had diastolic dysfunction. During a median follow-up of 5.7 years, 95 heart failure/death events occurred. Overall, diastolic dysfunction and natriuretic peptides were predictive of adverse events (respectively, hazard ratio 1.91, confidence interval 1.19–3.05, padjusted = 0.007, and hazard ratio 2.25, confidence interval 1.35–3.74, padjusted = 0.002) with Cox analysis. However, considering the four study subgroups, only the group with diastolic dysfunction/high natriuretic peptides had a significantly worse prognosis compared to the control group (hazard ratio 4.48, confidence interval 2.31–8.70, padjusted 
      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-02-04T04:45:00Z
      DOI: 10.1177/2047487319899618
       
  • Smoking status and mortality outcomes following percutaneous coronary
           intervention

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      Authors: Sathish Parasuraman, Azfar G Zaman, Mohaned Egred, Alan Bagnall, Paul A Broadhurst, Javed Ahmed, Richard Edwards, Raj Das, Deepak Garg, Ian Purcell, Awsan Noman
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.
      ObjectiveThe aim of this study was to assess the impact of smoking on short (30-day) and intermediate (30-day to 6-month) mortality following percutaneous coronary intervention (PCI).BackgroundThe effect of smoking on mortality post-PCI is lacking in the modern PCI era.MethodsThis was a retrospective analysis of prospectively collected data comparing short- and intermediate-term mortality amongst smokers, ex-smokers and non-smokers.ResultsThe study cohort consisted of 12,656 patients: never-smokers (n = 4288), ex-smokers (n = 4806) and current smokers (n = 3562). The mean age (±standard deviation) was 57 (±11) years in current smokers compared with 67 (±11) in ex-smokers and 67 (±12) in never-smokers; p 
      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-02-04T04:44:59Z
      DOI: 10.1177/2047487320902325
       
  • Impact of bedtime dosing of antihypertensives compared to morning therapy:
           A meta-analysis of randomised controlled trials

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      Authors: Rahul Gupta, Aaqib H Malik, Tarun Popli, Purva Ranchal, Srikanth Yandrapalli, Wilbert S Aronow
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-02-04T04:44:58Z
      DOI: 10.1177/2047487320903611
       
  • Psychometrics assessment of HeartQoL questionnaire: A Rasch analysis

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      Authors: Wan Ling Lee, Karuthan Chinna, Bambang Sumintono
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-02-04T04:44:56Z
      DOI: 10.1177/2047487320902322
       
  • The link between cardiovascular risk and cardiorespiratory fitness in
           individuals with a low socioeconomic status: An indisputable call for more
           action

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      Authors: Marco Guazzi
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.

      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-02-04T04:44:54Z
      DOI: 10.1177/2047487320901408
       
  • Trends in peripheral arterial disease incidence and mortality in EU15+
           countries 1990–2017

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      Authors: Richard Goodall, Justin D Salciccioli, Alun Huw Davies, Dominic Marshall, Joseph Shalhoub
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.
      AimsThe aim was to assess trends in peripheral arterial disease (PAD) incidence and mortality rates in European Union(15+) countries between 1990 and 2017.Methods and ResultsThis observational study used data obtained from the 2017 Global Burden of Disease study.Age-standardised mortality and incidence rates from PAD were extracted from the Global Health Data Exchange for EU15+ countries for the years 1990–2017. Trends were analysed using Joinpoint regression analysis.Between 1990 and 2017, the incidence of PAD decreased in all 19 EU15+ countries for females, and in 18 of 19 countries for males. Increasing PAD incidence was observed only for males in the United States (+1.4%). In 2017, the highest incidence rates were observed in Denmark and the United States for males (213.6 and 202.3 per 100,000, respectively) and in the United States and Canada for females (194.8 and 171.1 per 100,000, respectively). There was a concomitant overall trend for increasing age-standardised mortality rates in all EU15+ countries for females, and in 16 of 19 EU15+ countries for males between 1990 and 2017. Italy (–25.1%), Portugal (–1.9%) and Sweden (–0.6%) were the only countries with reducing PAD mortality rates in males. The largest increases in mortality rates were observed in the United Kingdom (males +140.4%, females +158.0%) and the United States (males +125.7%, females +131.2%).ConclusionsWe identify shifting burden of PAD in EU15+ countries, with increasing mortality rates despite reducing incidence. Strong evidence supports goal-directed medical therapy in reducing PAD mortality – population-wide strategies to improve compliance to optimal goal-directed medical therapy are warranted.
      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-02-04T04:44:53Z
      DOI: 10.1177/2047487319899626
       
  • Acute exposure to diesel affects inflammation and vascular function

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      Authors: Dimitris Tousoulis, Petros Fountoulakis, Evangelos Oikonomou, Charalambos Antoniades, Gerasimos Siasos, Sotirios Tsalamandris, Georgios Georgiopoulos, Zoi Pallantza, Efthimia Pavlou, Antigoni Milliou, Margarita N Assimakopoulos, Nikolaos Barmparesos, Ioannis Giannarakis, Pinelopi Siamata, Juan C Kaski
      Abstract: European Journal of Preventive Cardiology, Ahead of Print.
      BackgroundDiesel exhaust fumes represent one of the most common toxic pollutants. The prolonged effects of acute exposure to this pollutant on inflammatory status and vascular properties are unknown.MethodsDuring a 2-h session, 40 healthy subjects were exposed to diesel exhaust fumes and/or filtered air. Endothelial function was assessed with flow mediated dilation, arterial stiffness with pulse wave velocity and reflected waves with augmentation index. C-reactive protein, fibrinogen, protein C levels and protein S activity were also measured. Standard deviation of normal to normal R–R intervals (SDNN) was used to assess heart rate variability. Measurements were assessed before exposure and 2 and 24 h after diesel exposure.ResultsCompared with filtered air, exposure to diesel exhaust fumes decreased flow mediated dilation and increased pulse wave velocity and augmentation index up to 24 h after the exposure (p 
      Citation: European Journal of Preventive Cardiology
      PubDate: 2020-01-30T12:11:16Z
      DOI: 10.1177/2047487319898020