Subjects -> JOURNALISM AND PUBLICATION (Total: 219 journals)
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    - JOURNALISM AND PUBLICATION (148 journals)
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JOURNALISM AND PUBLICATION (148 journals)                     

Showing 1 - 17 of 17 Journals sorted alphabetically
#PerDebate     Open Access  
Actas Urológicas Españolas     Full-text available via subscription   (Followers: 1)
Advances in Journalism and Communication     Open Access   (Followers: 26)
Advances in Protein Chemistry and Structural Biology     Full-text available via subscription   (Followers: 18)
African Journalism Studies     Hybrid Journal   (Followers: 4)
American Journalism     Hybrid Journal   (Followers: 2)
Âncora : Revista Latino-Americana de Jornalismo     Open Access  
Annales françaises d'Oto-rhino-laryngologie et de Pathologie Cervico-faciale     Full-text available via subscription   (Followers: 2)
Apparence(s)     Open Access   (Followers: 1)
Archives of Cardiovascular Diseases Supplements     Full-text available via subscription   (Followers: 2)
Archivos de Medicina Veterinaria     Open Access   (Followers: 1)
Arethusa     Full-text available via subscription   (Followers: 5)
Arizona Journal of Hispanic Cultural Studies     Full-text available via subscription   (Followers: 5)
Arizona Quarterly: A Journal of American Literature, Culture, and Theory     Full-text available via subscription   (Followers: 18)
Asian Journal of Animal Sciences     Open Access   (Followers: 3)
Asian Journal of Information Management     Open Access   (Followers: 9)
Asian Journal of Marketing     Open Access   (Followers: 6)
Astérion     Open Access  
Atención Primaria     Open Access   (Followers: 2)
Australasian Marketing Journal (AMJ)     Hybrid Journal   (Followers: 4)
BMS: Bulletin of Sociological Methodology/Bulletin de Méthodologie Sociologique     Hybrid Journal   (Followers: 4)
Brazilian Journalism Research     Open Access   (Followers: 2)
British Journal of General Practice     Full-text available via subscription   (Followers: 39)
Brookings Papers on Economic Activity     Open Access   (Followers: 68)
Brookings-Wharton Papers on Financial Services     Full-text available via subscription   (Followers: 3)
Brookings-Wharton Papers on Urban Affairs     Full-text available via subscription   (Followers: 7)
Bulletin of the Comediantes     Full-text available via subscription   (Followers: 2)
Cahiers d'histoire. Revue d'histoire critique     Open Access   (Followers: 14)
Cahiers de la Méditerranée     Open Access   (Followers: 1)
CIC. Cuadernos de Informacion y Comunicacion     Open Access   (Followers: 4)
Communication & Society     Open Access   (Followers: 6)
Communication and Media in Asia Pacific (CMAP)     Open Access   (Followers: 2)
Communication Cultures in Africa     Open Access   (Followers: 7)
Communication Papers : Media Literacy & Gender Studies     Open Access   (Followers: 20)
Comunicação Pública     Open Access  
Comunicación y Ciudadanía     Open Access  
Connections : A Journal of Language, Media and Culture     Open Access   (Followers: 3)
Cuadernos.info     Open Access  
De Arte     Hybrid Journal   (Followers: 3)
Développement durable et territoires     Open Access   (Followers: 2)
Digital Journalism     Hybrid Journal   (Followers: 7)
Documentación de las Ciencias de la Información     Open Access  
E-rea     Open Access   (Followers: 2)
El Argonauta español     Open Access  
Espaço e Tempo Midiáticos     Open Access  
Estudios sobre el Mensaje Periodístico     Open Access   (Followers: 1)
Études caribéennes     Open Access   (Followers: 1)
European Science Editing     Open Access  
Frontiers in Research Metrics and Analytics     Open Access   (Followers: 4)
General Relativity and Gravitation     Hybrid Journal  
Géocarrefour     Open Access  
Grey Room     Hybrid Journal   (Followers: 16)
GRUR International     Full-text available via subscription  
Hipertext.net : Anuario Académico sobre Documentación Digital y Comunicación Interactiva     Open Access  
Improntas     Open Access  
In die Skriflig / In Luce Verbi     Open Access   (Followers: 3)
Index on Censorship     Hybrid Journal   (Followers: 2)
Information Today     Full-text available via subscription   (Followers: 34)
InMedia     Open Access  
International Journal of Bibliometrics in Business and Management     Hybrid Journal   (Followers: 2)
International Journal of Entertainment Technology and Management     Hybrid Journal   (Followers: 1)
Investment Analysts Journal     Hybrid Journal   (Followers: 1)
IRIS - Revista de Informação, Memória e Tecnologia     Open Access  
Journal of European Periodical Studies     Open Access   (Followers: 1)
Journal of Health Care for the Poor and Underserved     Full-text available via subscription   (Followers: 8)
Journal of Healthcare Risk Management     Hybrid Journal   (Followers: 10)
Journal of Illustration     Hybrid Journal   (Followers: 4)
Journal of Information Privacy and Security     Hybrid Journal   (Followers: 3)
Journal of Integrative Environmental Sciences     Hybrid Journal   (Followers: 4)
Journal of International and Intercultural Communication     Hybrid Journal   (Followers: 19)
Journal of Investigative and Clinical Dentistry     Hybrid Journal   (Followers: 2)
Journal of Islamic Law and Culture     Hybrid Journal   (Followers: 3)
Journal of Jewish Identities     Full-text available via subscription   (Followers: 11)
Journal of Late Antiquity     Full-text available via subscription   (Followers: 6)
Journal of Latin American Geography     Full-text available via subscription   (Followers: 7)
Journal of LGBT Youth     Hybrid Journal   (Followers: 12)
Journal of Literacy Research     Hybrid Journal   (Followers: 11)
Journal of Media Ethics : Exploring Questions of Media Morality     Hybrid Journal   (Followers: 14)
Journal of Medieval Iberian Studies     Hybrid Journal   (Followers: 8)
Journal of the Early Republic     Full-text available via subscription   (Followers: 13)
Journal of the Short Story in English     Open Access   (Followers: 7)
Journal of Thyroid Research     Open Access   (Followers: 1)
Journal of Transatlantic Studies     Hybrid Journal   (Followers: 5)
Journal of World History     Full-text available via subscription   (Followers: 32)
Journalism & Mass Communication Educator     Hybrid Journal   (Followers: 21)
Journalism & Communication Monographs     Hybrid Journal   (Followers: 19)
Journalism & Mass Communication Quarterly     Hybrid Journal   (Followers: 28)
Journalism History     Hybrid Journal   (Followers: 1)
Journalism Research     Open Access   (Followers: 4)
Journalistica - Tidsskrift for forskning i journalistik     Open Access   (Followers: 1)
Komunika     Open Access  
L'Espace Politique     Open Access  
L'Homme     Open Access   (Followers: 10)
La corónica : A Journal of Medieval Hispanic Languages, Literatures, and Cultures     Full-text available via subscription   (Followers: 4)
La Presse Médicale     Full-text available via subscription   (Followers: 3)
Language     Full-text available via subscription   (Followers: 30)
Latin American Perspectives     Hybrid Journal   (Followers: 15)
Latin American Research Review     Full-text available via subscription   (Followers: 16)
Law, State and Telecommunications Review     Open Access  
Les Cahiers d'Outre-Mer     Open Access   (Followers: 1)
Media & Jornalismo     Open Access  
Memory     Hybrid Journal   (Followers: 20)
Merrill-Palmer Quarterly     Full-text available via subscription   (Followers: 1)
Missionalia : Southern African Journal of Mission Studies     Open Access   (Followers: 3)
Museum International Edition Francaise     Hybrid Journal   (Followers: 3)
Natural Language Semantics     Hybrid Journal   (Followers: 8)
Newspaper Research Journal     Full-text available via subscription  
Nordic Journal of Media Management     Open Access   (Followers: 1)
Norsk medietidsskrift     Open Access  
OJS på dansk     Open Access   (Followers: 3)
Papers of The Bibliographical Society of Canada     Open Access  
Periodica Mathematica Hungarica     Full-text available via subscription   (Followers: 1)
Physics of the Solid State     Hybrid Journal   (Followers: 7)
Pollack Periodica     Full-text available via subscription  
Pozo de Letras     Open Access  
Prometheus : Critical Studies in Innovation     Hybrid Journal   (Followers: 3)
Publishers Weekly     Free   (Followers: 2)
Religion, State and Society     Hybrid Journal   (Followers: 5)
Research Integrity and Peer Review     Open Access  
Revista Observatório     Open Access  
Revue archéologique de l'Est     Open Access   (Followers: 3)
Revue archéologique du Centre de la France     Open Access   (Followers: 1)
Revue d’économie industrielle     Open Access  
Revue européenne des migrations internationales     Open Access   (Followers: 2)
RUDN Journal of Studies in Literature and Journalism     Open Access  
Scientometrics     Hybrid Journal   (Followers: 42)
Sensorium Journal     Open Access  
Signo y Pensamiento     Open Access  
Southern African Journal of Anaesthesia and Analgesia     Open Access   (Followers: 7)
Stellenbosch Theological Journal     Open Access   (Followers: 2)
Studia Socialia Cracoviensia     Open Access  
Syntax     Hybrid Journal   (Followers: 4)
Sztuka Edycji     Open Access   (Followers: 4)
TD : The Journal for Transdisciplinary Research in Southern Africa     Open Access  
Time     Full-text available via subscription   (Followers: 5)
Tracés     Open Access  
Transport Policy     Hybrid Journal   (Followers: 12)
Trípodos     Open Access  
Tydskrif vir Geesteswetenskappe     Open Access  
Tydskrif vir Letterkunde     Open Access  
Ufahamu : A Journal of African Studies     Open Access   (Followers: 1)
Variants : Journal of the European Society for Textual Scholarship     Open Access  
Verbum et Ecclesia     Open Access   (Followers: 2)
World Futures: Journal of General Evolution     Hybrid Journal   (Followers: 1)

           

Similar Journals
Journal Cover
Journal of Thyroid Research
Journal Prestige (SJR): 0.573
Citation Impact (citeScore): 2
Number of Followers: 1  

  This is an Open Access Journal Open Access journal
ISSN (Online) 2042-0072
Published by Hindawi Homepage  [339 journals]
  • Subclinical Hypothyroidism in Advanced Chronic Kidney Disease Patients:
           Prevalence and Associated Factors

    • Abstract: Introduction. Renal function and thyroid metabolism are tightly related. However, evidence about subclinical hypothyroidism prevalence in patients with chronic kidney disease and its related factors is scarce. Objectives. Our aim is to analyze subclinical hypothyroidism prevalence and its related factors in patients with advanced chronic kidney disease. Materials and methods. Nondialysis-dependent patients with chronic kidney disease at stages 3 to 5 were included. Other inclusion criteria were age above 18 years and clinical stability. Patients with diagnosed thyroid illnesses were excluded. Subclinical hypothyroidism was defined as thyroid stimulating hormone (TSH) > 5.3 mU/L, with free thyroxine 4 (FT4) between 0.54 and 1.24 ng/dl. Filiation data, comorbidities, and routine blood and urine test results were registered. Results. A total of 299 patients were included. Of them, 184 (61.5%) were men. The mean age was 71 ± 13 years old. The mean glomerular filtration rate (CKD-EPI) was 22 ± 9 ml/min/1.73 m2. According to chronic kidney disease stages, global distribution of patients was as follows: Stage 3, 67 patients (22.4%); Stage 4, 155 patients (51.8%); and Stage 5, 77 patients (25.8%). We found subclinical hypothyroidism in 54 (18.1%) patients. According to chronic kidney disease stages, distribution of affected patients was as follows: Stage 3, 9 patients (13%); Stage 4, 25 patients (16.1%); and Stage 5, 20 patients (26%). Differences among stages were statistically significant. By univariate analysis, factors related with subclinical hypothyroidism were as follows: age RR 1.048 (95% CI 1.019–1.078; ), hypertension RR 2.705 (95% CI 1.026–7.130; ), glomerular filtration rate RR 0.962 (95% CI 0.929–0.996; ), and proteinuria higher than 1 gram/day RR 2.387 (95% CI 1.303–4.374; ). By multivariate analysis adjusted by age, hypertension, glomerular filtration rate, proteinuria, diabetes, and cardiovascular disease history, only age RR 1.016 (95% CI 1.009–1.028; ) and glomerular filtration rate RR 0.963 (95% CI 0.930–0.997; ) preserved their independent association with subclinical hypothyroidism. Conclusions. Subclinical hypothyroidism prevalence in patients with chronic kidney disease is high and increases with renal disease severity. Factors independently related to subclinical hypothyroidism are age and glomerular filtration rate.
      PubDate: Tue, 17 May 2022 17:50:08 +000
       
  • Thyroid Signaling Biomarkers in Female Symptomatic Hypothyroid Patients on
           Liothyronine versus Levothyroxine Monotherapy: A Randomized Crossover
           Trial

    • Abstract: Background. Levels of thyroid-stimulating hormone (TSH) are believed to reflect degree of disease in patients with hypothyroidism, and normalization of levels is the treatment goal. However, despite adequate levels of TSH after starting levothyroxine (LT4) therapy, 5–10% of hypothyroid patients complain of persisting symptoms with a significant negative impact on quality of life. This indicates that TSH is not an optimal indicator of intracellular thyroid hormone effects in all patients. Our aim was to investigate different effects of LT3 and LT4 monotherapy on other biomarkers of the thyroid signaling pathway, in addition to adverse effects, in patients with residual hypothyroid symptoms. Methods. Fifty-nine female hypothyroid patients, with residual symptoms on LT4 monotherapy or LT4/liothyronine (LT3) combination therapy, were randomly assigned in a non-blinded crossover study and received LT4 or LT3 monotherapy for 12 weeks each. Measurements, including serum analysis of a number of biochemical and hormonal parameters, were obtained at the baseline visit and after both treatment periods. Results. Free thyroxine (FT4) was higher in the LT4 group, while free triiodothyronine (FT3) was higher in the LT3 group. The levels of reverse triiodothyronine (rT3) decreased after LT3 treatment compared with LT4 treatment. Both low-density lipoprotein (LDL) and total cholesterol levels were reduced, while sex hormone-binding globulin (SHBG) increased after LT3 treatment compared with LT4 treatment. The median TSH levels for both treatment groups were within the reference range, however, lower in the LT4 group than in the LT3 group. We did not find any differences in pro-B-type natriuretic peptide (NT pro-BNP), handgrip strength, bone turnover markers, or adverse events between the two treatment groups. Conclusion. We have demonstrated that FT4, FT3, rT3, cholesterol, and SHBG show significantly different values on LT4 treatment compared with LT3 treatment in women with hypothyroidism and residual symptoms despite normal TSH levels. No differences in general or bone-specific adverse effects were demonstrated. This trial is registered with NCT03627611 in May 2018.
      PubDate: Wed, 04 May 2022 11:05:01 +000
       
  • Short-Term Adverse Pregnancy Outcomes in Women with Subclinical
           

    • Abstract: Introduction. Subclinical hypothyroidism during pregnancy can be associated with numerous adverse outcomes. The purpose of this study was to compare short-term adverse pregnancy outcomes in treated versus nontreated patients who fall within the numerical range of thyroid-stimulating hormone (TSH) between the Iranian and American reference ranges. Materials and Methods. Eighty pregnant women with a known level of antithyroid peroxidase (anti-TPO) and TSH levels of 2.5–3.9 mIu/L in the first trimester and 3–4.1 mIu/L in the second and third trimesters were enrolled in the study and randomly assigned into two groups including 41 patients in the intervention group and 39 in the control group. The intervention group was treated with levothyroxine at least 50 μg/day and the control group received no treatment. The data were analyzed by SPSS software version 23. Results. The only significant findings were a correlation between pregnancy loss frequency (p − 0.011) and/or increased TSH level in the follow-up period (p = 0.008) with anti-TPO antibody positivity. Forty-four percent of mothers with positive anti-TPO Ab needed treatment initiation with levothyroxine, based on Iranian guidelines, due to increased TSH level during the follow-up period. Conclusion. Untreated pregnant women with subclinical hypothyroidism, who were placed in the intermediate range of TSH, recommended by Iranian and American guidelines, did not show any significant difference in short-term adverse pregnancy outcomes compared to the treated patients. Positive anti-TPO Ab may play a role in the development of short-term complications in mothers with subclinical hypothyroidism or it may increase the likelihood of an increase in TSH level during pregnancy.
      PubDate: Sat, 05 Mar 2022 12:20:00 +000
       
  • Corrigendum to “There Is No Elevation of Immunoglobulin E Levels in
           Albanian Patients with Autoimmune Thyroid Diseases”

    • PubDate: Mon, 21 Feb 2022 17:50:00 +000
       
  • Clinicopathological Profile of Thyroid Carcinoma in Young Patients: An
           Indonesian Single-Center Study

    • Abstract: Introduction. Thyroid cancer is the third most common cancer that occurs in children and adolescents. Papillary thyroid carcinoma (PTC) is the most common type of thyroid malignancy. Although the mortality rate of thyroid malignancy in children is usually low, the disease recurrence is higher in children with more severe clinical presentation than in adults. This study aimed to determine the demographic and clinicopathological characteristics and outcome of pediatric and adolescent patients with thyroid malignancy in Indonesia. Methods. The retrospective study included all patients diagnosed with thyroid carcinoma aged
      PubDate: Tue, 11 Jan 2022 06:50:01 +000
       
  • RET Proto-Oncogene Mutational Analysis in 45 Iranian Patients Affected
           with Medullary Thyroid Carcinoma: Report of a New Variant

    • Abstract: Background. The aim of this study was to identify germline mutation of the RET (rearranged during transfection) gene in patients with medullary thyroid carcinoma (MTC) and their first-degree relatives to find presymptomatic carriers for possible prophylactic thyroidectomy. Methods/Patients. We examined all six hot spot exons (exons 10, 11, 13, and 14–16) of the RET gene by PCR and bidirectional Sanger sequencing in 45 Iranian patients with MTC (either sporadic or familial form) from 7 unrelated kindred and 38 apparently sporadic cases. First-degree relatives of RET positive cases were also genotyped for index mutation. Moreover, presymptomatic carriers were referred to the endocrinologist for further clinical management and prophylactic thyroidectomy if needed. Results. Overall, the genetic status of all of the participants was determined by RET mutation screening, including 61 affected individuals, 22 presymptomatic carriers, and 29 genetically healthy subjects. In 37.5% (17 of 45) of the MTC referral index patients, 8 distinct RET germline mutations were found, including p.C634R (35.3%), p.M918T (17.6%), p.C634Y (11.8%), p.C634F (5.9%), p.C611Y (5.9%), p.C618R (5.9%), p.C630R (5.9%), p.L790F (5.9%), and one uncertain variant p.V648I (5.9%). Also, we found a novel variant p.H648R in one of our apparently sporadic patients. Conclusion. RET mutation detection is a promising/golden screening test and provides an accurate presymptomatic diagnostic test for at-risk carriers (the siblings and offspring of the patients) to consider prophylactic thyroidectomy. Thus, according to the ATA recommendations, the screening of the RET proto-oncogene is indicated for patients with MTC.
      PubDate: Wed, 03 Nov 2021 18:05:00 +000
       
  • Effect of Micronutrients on Thyroid Parameters

    • Abstract: Micronutrients are involved in various vital cellular metabolic processes including thyroid hormone metabolism. This study aimed to investigate the correlation between serum levels of micronutrients and their effects on thyroid parameters. The correlation of serum levels of micronutrients and thyroid markers was studied in a group of 387 healthy individuals tested for thyroid markers (T4, T3, FT4, FT3, TSH, anti-TPO, RT3, and anti-Tg) and their micronutrient profile at Vibrant America Clinical Laboratory. The subjects were rationalized into three groups (deficient, normal, or excess levels of micronutrients), and the levels of their thyroid markers were compared. According to our results, deficiency of vitamin B2, B12, and B9 and Vit-D25[OH] () significantly affected thyroid functioning. Other elemental micronutrients such as calcium, copper, choline, iron, and zinc () have a significant correlation with serum levels of free T3. Amino acids asparagine (r = 0.1765, ) and serine (r = 0.1186, ) were found to have a strong positive correlation with TSH. Valine, leucine, and arginine () also exhibited a significant positive correlation with serum levels of T4 and FT4. No other significant correlations were observed with other micronutrients. Our study suggests strong evidence for the association of the levels of micronutrients with thyroid markers with a special note on the effect of serum levels of certain amino acids.
      PubDate: Tue, 28 Sep 2021 12:20:00 +000
       
  • Association of Polygenetic Risk Scores Related to Immunity and
           Inflammation with Hyperthyroidism Risk and Interactions between the
           Polygenetic Scores and Dietary Factors in a Large Cohort

    • Abstract: Graves’s disease and thyroiditis induce hyperthyroidism, the causes of which remain unclear, although they are involved with genetic and environmental factors. We aimed to evaluate polygenetic variants for hyperthyroidism risk and their interaction with metabolic parameters and nutritional intakes in an urban hospital-based cohort. A genome-wide association study (GWAS) of participants with (cases; n = 842) and without (controls, n = 38,799) hyperthyroidism was used to identify and select genetic variants. In clinical and lifestyle interaction with PRS, 312 participants cured of hyperthyroidism were excluded. Single nucleotide polymorphisms (SNPs) associated with gene-gene interactions were selected by hyperthyroidism generalized multifactor dimensionality reduction. Polygenic risk scores (PRSs) were generated by summing the numbers of selected SNP risk alleles. The best gene-gene interaction model included tumor-necrosis factor (TNF)_rs1800610, mucin 22 (MUC22)_rs1304322089, tribbles pseudokinase 2 (TRIB2)_rs1881145, cytotoxic T-lymphocyte-associated antigen 4 (CTLA4)_rs231775, lipoma-preferred partner (LPP)_rs6780858, and human leukocyte antigen (HLA)-J_ rs767861647. The PRS of the best model was positively associated with hyperthyroidism risk by 1.939-fold (1.317–2.854) after adjusting for covariates. PRSs interacted with age, metabolic syndrome, and dietary inflammatory index (DII), while hyperthyroidism risk interacted with energy, calcium, seaweed, milk, and coffee intake (). The PRS impact on hyperthyroidism risk was observed in younger (
      PubDate: Wed, 15 Sep 2021 10:35:01 +000
       
  • Immunohistochemical Analysis of Toll-Like Receptors, MyD88, and TRIF in
           Human Papillary Thyroid Carcinoma and Anaplastic Thyroid Carcinoma

    • Abstract: Purpose. We hypothesized that innate immune response pathways might be involved in thyroid carcinogenesis. To investigate this hypothesis, we aimed at analyzing the expression of several receptors and molecules in the innate immune system in papillary thyroid carcinoma (PTC) and anaplastic thyroid carcinoma (ATC) tissues. Methods. Of the surgically resected specimens, 11 ATC tissues, 25 PTC tissues, and 8 nodular hyperplasia (NH) tissues were selected and examined for the expression of toll-like receptor (TLR) 2, TLR3, TLR4, TLR5, TLR7, TLR9, the myeloid differentiation primary response gene 88 (MyD88), and toll-interleukin-1 receptor domain-containing adaptor inducing INF-β (TRIF) by immunohistochemistry (IHC). Results. Several TLRs were expressed in each tissue. TLR3 was strongly expressed in all tissues. In contrast, TLR4 was not detected in any tissues. While TLR5 was moderately expressed in NH but significantly reduced in PTC and ATC, TLR9 was absent in NH tissue but moderately expressed in both PTC and ATC. On MyD88 expression, no significant difference was found between PTC and ATC. TRIF was significantly upregulated in PTC and ATC compared to NH. Surprisingly, PTC and ATC tissues exhibited similar expression patterns of TLRs, MyD88, and TRIF. Conclusion. These data suggest the involvement of the innate immune system in both PTC and ATC. Specifically, TLR3-mediated TRIF activation was confirmed in PTC and ATC. This provides new insight into thyroid carcinogenesis.
      PubDate: Fri, 02 Jul 2021 07:35:00 +000
       
  • Modulating Thyroid Hormone Levels in Adult Mice: Impact on Behavior and
           Compensatory Brain Changes

    • Abstract: Thyroid hormone (TH) perturbation is a common medical problem. Because of substantial public health impact, prior researchers have studied hyper- and hypothyroidism in animal models. Although most prior research focused on in utero and/or developmental effects, changes in circulating TH levels are commonly seen in elderly individuals: approximately 20% of persons older than 80 years have clinically impactful hypothyroidism and up to 5% have clinical hyperthyroidism, with women being more often affected than men. TH disease model methodology in mice have varied but usually focus on a single sex, and the impact(s) of TH perturbation on the adult brain are not well understood. We administered thyroxine to middle-aged (13 to 14 months) male and female mice to model hyperthyroidism and TH-lowering drugs propylthiouracil (PTU) and methimazole, to induce hypothyroidism. These pharmacological agents are used commonly in adult humans. Circulating TH-level changes were observed when thyroxine was dosed at 20 µg/mL in drinking water for two weeks. By contrast, PTU and methimazole did not elicit a consistent reproducible effect until two months of treatment. No substantial changes in TH levels were detected in brain tissues of treated animals; however, pronounced changes in gene expression, specifically for TH-processing transcripts, were observed following the treatment with thyroxine. Our study indicated a robust compensatory mechanism by which the brain tissue/cells minimize the TH fluctuation in CNS by altering gene expression. Neurobehavioral changes were related to the TH perturbation and suggested potential associations between cognitive status and hyper- and hypothyroidism.
      PubDate: Fri, 25 Jun 2021 05:20:00 +000
       
  • Predictors of Improvement in Quality of Life When Treating Hypothyroidism

    • Abstract: Background. Primary hypothyroidism is characterized by reduced quality of life (QoL). Although thyrotropin (TSH) is utilized as the primary indicator of thyroid disease and treatment adequacy, no simple correlation between QoL and TSH has been shown. This study aimed to investigate changes in clinically relevant predictors during initiation of levothyroxine (L-T4) therapy and their ability to predict improvement in QoL. Method. Quality of life was measured in patients with newly diagnosed hypothyroidism, during the initial 12 months of L-T4 therapy, by the thyroid-related patient-reported outcome questionnaire, ThyPRO-39. The main outcome measures were the Composite QoL scale and the Tiredness and Emotional Susceptibility subscales (0–100, higher scores worse). Clinical variables (resting energy expenditure (REE), body composition, thyroid function, L-T4 dose, and cognitive function tests) were evaluated as predictors of improvement in QoL by univariate and multiple regression analysis. Results. Thirty-seven hypothyroid patients with a baseline median TSH of 30 mU/l and a median QoL score of 29 were included. After twelve months of L-T4 treatment, the ThyPRO-39 QoL score had significantly improved to a median score of 14, while REE per kg fat-free mass (FFM) increased significantly from a mean of 26.5 to 28.7 kcal/day/kg (). Change in ThyPRO-39 was not associated with a change in REE/FFM (unstandardized coefficient (USC): 0.09 with confidence interval (CI): −1.93 to 2.11, ) but was positively predicted by baseline body mass index (BMI) (USC: 1.54 with CI: 0.59 to 2.49, (), without association with weight loss (USC: 0.33 with CI: −1.21 to 1.27, ).Conclusion. Improvement in QoL as measured by ThyPRO-39 after initiation of L-T4 therapy for hypothyroidism was not associated with changes in REE. High baseline BMI, but not weight loss during therapy, was associated with improvement in QoL. This trail is registered with www.Clinicaltrials.gov (registration no. https://clinicaltrials.gov/ct2/show/NCT02891668).
      PubDate: Sat, 12 Jun 2021 06:35:01 +000
       
  • Retracted: Thyrotoxic Periodic Paralysis: Clinical Challenges

    • PubDate: Tue, 16 Mar 2021 11:05:00 +000
       
  • Prevalence of Hypothyroidism in Pregnant Women in India: A Meta-Analysis
           of Observational Studies

    • Abstract: Introduction. This meta-analysis was conducted to estimate the prevalence of hypothyroidism among pregnant women in India. Methods. We searched PubMed, Web of Science, Scopus, Google Scholar, and Shodhganga (Indian thesis repository) for observational studies, providing prevalence of hypothyroidism among pregnant women in India. Systematic study selection and data extraction procedures were followed. Quality assessment of each study was done using JBI critical appraisal checklist. The random effects model was used for pooling the effect sizes. Publication bias was assessed using the funnel plot and rank correlation test. I2 statistics was used to measure heterogeneity across the studies. Heterogeneity in the pooled estimates was further explored with subgroup analyses and meta-regression analysis. Results. Sixty-one studies were found eligible and included in this review. The pooled estimate of the prevalence of hypothyroidism in pregnant women was 11.07% (95% CI: 8.79–13.84, I2 = 99%). Pooled prevalence estimates of subclinical and overt hypothyroidism are 9.51% (95% CI: 7.48–12.04, I2 = 98%) and 2.74% (95% CI: 2.08–3.58, I2 = 94%). Conclusion. We documented 11.07% pooled prevalence of hypothyroidism in pregnant women in India.
      PubDate: Fri, 19 Feb 2021 09:35:00 +000
       
 
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