Subjects -> MEDICAL SCIENCES (Total: 8212 journals)
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MEDICAL SCIENCES (2241 journals)                  1 2 3 4 5 6 7 8 | Last

Showing 1 - 200 of 3562 Journals sorted alphabetically
16 de Abril     Open Access   (Followers: 1)
3D Printing in Medicine     Open Access   (Followers: 5)
4 open     Open Access  
AADE in Practice     Hybrid Journal   (Followers: 2)
AAS Open Research     Open Access  
ABCS Health Sciences     Open Access   (Followers: 3)
Abia State University Medical Students' Association Journal     Full-text available via subscription   (Followers: 1)
AboutOpen     Open Access  
ACIMED     Open Access  
ACM Transactions on Computing for Healthcare     Hybrid Journal  
ACS Medicinal Chemistry Letters     Hybrid Journal   (Followers: 42)
Acta Bio Medica     Open Access   (Followers: 1)
Acta Bioethica     Open Access  
Acta Bioquimica Clinica Latinoamericana     Open Access   (Followers: 1)
Acta Herediana     Open Access  
Acta Marisiensis - Seria Medica     Open Access  
Acta Medica (Hradec Králové)     Open Access  
Acta Medica Bulgarica     Open Access  
Acta Medica Colombiana     Open Access   (Followers: 1)
Acta Médica Costarricense     Open Access   (Followers: 2)
Acta Medica Indonesiana     Open Access  
Acta Medica International     Open Access  
Acta Medica Iranica     Open Access  
Acta medica Lituanica     Open Access  
Acta Medica Martiniana     Open Access  
Acta Medica Peruana     Open Access   (Followers: 1)
Acta Scientiarum. Health Sciences     Open Access   (Followers: 2)
Acupuncture & Electro-Therapeutics Research     Full-text available via subscription   (Followers: 3)
Acupuncture and Herbal Medicine     Open Access   (Followers: 1)
Addiction Science & Clinical Practice     Open Access   (Followers: 9)
Addictive Behaviors Reports     Open Access   (Followers: 8)
Adıyaman Üniversitesi Sağlık Bilimleri Dergisi / Health Sciences Journal of Adıyaman University     Open Access  
Adnan Menderes Üniversitesi Sağlık Bilimleri Fakültesi Dergisi     Open Access  
Advanced Health Care Technologies     Open Access   (Followers: 12)
Advanced NanoBiomed Research     Open Access   (Followers: 1)
Advanced Science, Engineering and Medicine     Partially Free   (Followers: 4)
Advanced Therapeutics     Hybrid Journal   (Followers: 1)
Advances in Bioscience and Clinical Medicine     Open Access   (Followers: 6)
Advances in Cell and Gene Therapy     Hybrid Journal   (Followers: 1)
Advances in Clinical Chemistry     Full-text available via subscription   (Followers: 24)
Advances in Clinical Radiology     Full-text available via subscription   (Followers: 4)
Advances in Life Course Research     Hybrid Journal   (Followers: 7)
Advances in Medical Education and Practice     Open Access   (Followers: 29)
Advances in Medical Sciences     Hybrid Journal   (Followers: 7)
Advances in Medicine     Open Access   (Followers: 3)
Advances in Microbial Physiology     Full-text available via subscription   (Followers: 3)
Advances in Parkinson's Disease     Open Access   (Followers: 2)
Advances in Preventive Medicine     Open Access   (Followers: 6)
Advances in Protein Chemistry and Structural Biology     Full-text available via subscription   (Followers: 18)
Advances in Regenerative Medicine     Open Access   (Followers: 3)
Advances in Therapy     Hybrid Journal   (Followers: 5)
Advances in Traditional Medicine     Hybrid Journal   (Followers: 3)
Advances in Virus Research     Full-text available via subscription   (Followers: 7)
Advances in Wound Care     Hybrid Journal   (Followers: 14)
Aerospace Medicine and Human Performance     Full-text available via subscription   (Followers: 22)
African Health Sciences     Open Access   (Followers: 6)
African Journal of Biomedical Research     Open Access  
African Journal of Clinical and Experimental Microbiology     Open Access  
African Journal of Laboratory Medicine     Open Access   (Followers: 2)
African Journal of Medical and Health Sciences     Open Access  
Afrimedic Journal     Open Access   (Followers: 3)
AIDS Research and Human Retroviruses     Hybrid Journal   (Followers: 9)
Airway     Open Access   (Followers: 3)
AJOB Empirical Bioethics     Hybrid Journal   (Followers: 3)
AJSP: Reviews & Reports     Hybrid Journal  
Aktuelle Ernährungsmedizin     Hybrid Journal   (Followers: 4)
AkupunkturPraxis     Full-text available via subscription   (Followers: 3)
Al-Azhar Assiut Medical Journal     Open Access   (Followers: 1)
Al-Qadisiah Medical Journal     Open Access  
Alerta : Revista Científica del Instituto Nacional de Salud     Open Access  
Alexandria Journal of Medicine     Open Access  
Allgemeine Homöopathische Zeitung     Hybrid Journal   (Followers: 1)
ALTEX : Alternatives to Animal Experimentation     Open Access   (Followers: 1)
American Journal of Biomedical Engineering     Open Access   (Followers: 10)
American Journal of Biomedical Research     Open Access   (Followers: 2)
American Journal of Biomedicine     Full-text available via subscription  
American Journal of Chinese Medicine, The     Hybrid Journal   (Followers: 2)
American Journal of Clinical Medicine Research     Open Access   (Followers: 5)
American Journal of Family Therapy     Hybrid Journal   (Followers: 6)
American Journal of Law & Medicine     Full-text available via subscription   (Followers: 10)
American Journal of Lifestyle Medicine     Hybrid Journal   (Followers: 5)
American Journal of Managed Care     Full-text available via subscription   (Followers: 13)
American Journal of Medical Case Reports     Open Access  
American Journal of Medical Sciences and Medicine     Open Access   (Followers: 2)
American Journal of Medicine     Hybrid Journal   (Followers: 47)
American Journal of Medicine and Medical Sciences     Open Access   (Followers: 1)
American Journal of Medicine Open     Open Access   (Followers: 3)
American Journal of Medicine Studies     Open Access   (Followers: 3)
American Journal of Medicine Supplements     Full-text available via subscription   (Followers: 3)
American Journal of the Medical Sciences     Hybrid Journal   (Followers: 11)
American Journal on Addictions     Hybrid Journal   (Followers: 11)
American medical news     Free   (Followers: 3)
Amrita Journal of Medicine     Open Access   (Followers: 3)
Amyloid: The Journal of Protein Folding Disorders     Hybrid Journal   (Followers: 6)
Anales de la Facultad de Medicina     Open Access  
Anales de la Facultad de Medicina, Universidad de la República, Uruguay     Open Access  
Anales del Sistema Sanitario de Navarra     Open Access   (Followers: 1)
Analgesia & Resuscitation : Current Research     Hybrid Journal   (Followers: 5)
Anatolian Clinic the Journal of Medical Sciences     Open Access  
Anatomica Medical Journal     Open Access  
Anatomical Science International     Hybrid Journal   (Followers: 3)
Anatomical Sciences Education     Hybrid Journal   (Followers: 1)
Anatomy     Open Access   (Followers: 3)
Anatomy Research International     Open Access   (Followers: 4)
Androgens : Clinical Research and Therapeutics     Open Access  
Angewandte Nuklearmedizin     Full-text available via subscription   (Followers: 3)
Angewandte Schmerztherapie und Palliativmedizin     Hybrid Journal  
Angiogenesis     Hybrid Journal   (Followers: 2)
Animal Diseases     Open Access  
Annales de Pathologie     Full-text available via subscription  
Annales françaises d'Oto-rhino-laryngologie et de Pathologie Cervico-faciale     Full-text available via subscription   (Followers: 2)
Annals of 3D Printed Medicine     Open Access  
Annals of African Medicine     Open Access   (Followers: 2)
Annals of Anatomy - Anatomischer Anzeiger     Hybrid Journal   (Followers: 2)
Annals of Biomedical Engineering     Hybrid Journal   (Followers: 18)
Annals of Biomedical Sciences     Full-text available via subscription   (Followers: 3)
Annals of Clinical and Medical Case Reports     Open Access  
Annals of Clinical Hypertension     Open Access  
Annals of Clinical Microbiology and Antimicrobials     Open Access   (Followers: 9)
Annals of Family Medicine     Open Access   (Followers: 14)
Annals of Health Research     Open Access   (Followers: 2)
Annals of Ibadan Postgraduate Medicine     Open Access  
Annals of Medical and Health Sciences Research     Open Access   (Followers: 5)
Annals of Medicine     Hybrid Journal   (Followers: 11)
Annals of Medicine and Surgery     Open Access   (Followers: 7)
Annals of Medicine and Surgery Case Reports     Open Access   (Followers: 1)
Annals of Medicine and Surgery Protocols     Open Access  
Annals of Microbiology     Open Access   (Followers: 9)
Annals of Musculoskeletal Medicine     Open Access  
Annals of Rehabilitation Medicine     Open Access   (Followers: 1)
Annals of Saudi Medicine     Open Access  
Annals of the College of Medicine, Mosul     Open Access  
Annals of the National Academy of Medical Sciences (India)     Open Access  
Annals of the New York Academy of Sciences     Hybrid Journal   (Followers: 5)
Annals of The Royal College of Surgeons of England     Full-text available via subscription   (Followers: 3)
Annals of the RussianAacademy of Medical Sciences     Open Access  
Annals of Vascular Surgery - Brief Reports and Innovations     Full-text available via subscription  
Annual Reports in Medicinal Chemistry     Full-text available via subscription   (Followers: 6)
Annual Reports on NMR Spectroscopy     Full-text available via subscription   (Followers: 4)
Annual Review of Medicine     Full-text available via subscription   (Followers: 18)
Anthropological Review     Open Access   (Followers: 27)
Anthropologie et santé     Open Access   (Followers: 4)
Antibiotics     Open Access   (Followers: 10)
Antibodies     Open Access   (Followers: 2)
Antibody Reports     Open Access  
Antibody Therapeutics     Open Access  
Anuradhapura Medical Journal     Open Access  
Anwer Khan Modern Medical College Journal     Open Access  
Apmis     Hybrid Journal   (Followers: 1)
Apparence(s)     Open Access   (Followers: 1)
Applied Clinical Informatics     Hybrid Journal   (Followers: 4)
Applied Medical Informatics     Open Access   (Followers: 11)
Arab Journal of Nephrology and Transplantation     Open Access   (Followers: 2)
Arabian Journal of Scientific Research / المجلة العربية للبحث العلمي     Open Access  
Archive of Biomedical Science and Engineering     Open Access  
Archive of Clinical Medicine     Open Access   (Followers: 1)
Archives Medical Review Journal / Arşiv Kaynak Tarama Dergisi     Open Access  
Archives of Asthma, Allergy and Immunology     Open Access   (Followers: 1)
Archives of Clinical Hypertension     Open Access  
Archives of Medical and Biomedical Research     Open Access   (Followers: 2)
Archives of Medical Laboratory Sciences     Open Access  
Archives of Medicine and Health Sciences     Open Access   (Followers: 5)
Archives of Organ Transplantation     Open Access  
Archives of Preventive Medicine     Open Access  
Archives of Pulmonology and Respiratory Care     Open Access  
Archives of Renal Diseases and Management     Open Access  
Archives of Trauma Research     Open Access   (Followers: 4)
Arquivos de Medicina     Open Access  
Ars Medica : Revista de Ciencias Médicas     Open Access  
ARS Medica Tomitana     Open Access  
Art Therapy: Journal of the American Art Therapy Association     Hybrid Journal   (Followers: 14)
Arterial Hypertension     Open Access  
Artificial Intelligence in Medicine     Hybrid Journal   (Followers: 19)
Artificial Organs     Hybrid Journal   (Followers: 1)
ASA Monitor     Full-text available via subscription   (Followers: 1)
Asia Pacific Journal of Clinical Nutrition     Full-text available via subscription   (Followers: 10)
Asian Bioethics Review     Full-text available via subscription   (Followers: 2)
Asian Journal of Cell Biology     Open Access   (Followers: 4)
Asian Journal of Health     Open Access   (Followers: 3)
Asian Journal of Medical and Biological Research     Open Access   (Followers: 3)
Asian Journal of Medical and Pharmaceutical Researches     Open Access  
Asian Journal of Medical Sciences     Open Access   (Followers: 2)
Asian Journal of Medicine and Health     Open Access   (Followers: 1)
Asian Journal of Population Sciences     Open Access   (Followers: 1)
Asian Journal of Research in Medical and Pharmaceutical Sciences     Open Access  
Asian Journal of Scientific Research     Open Access   (Followers: 2)
Asian Journal of Social Health and Behavior     Open Access   (Followers: 3)
Asian Journal of Transfusion Science     Open Access  
Asian Medicine     Hybrid Journal   (Followers: 5)
Asian Pacific Journal of Health Sciences     Open Access   (Followers: 2)
ASPIRATOR : Journal of Vector-borne Disease Studies     Open Access  
Atención Primaria     Open Access   (Followers: 2)
Atención Primaria Práctica     Open Access  
Atti della Accademia Peloritana dei Pericolanti - Classe di Scienze Medico-Biologiche     Open Access  
Auris Nasus Larynx     Full-text available via subscription  
Australasian Journal of Ultrasound in Medicine (AJUM)     Hybrid Journal   (Followers: 1)
Australian Family Physician     Full-text available via subscription   (Followers: 3)
Australian Journal of Medical Science     Full-text available via subscription   (Followers: 4)
Autopsy and Case Reports     Open Access  
Avicenna     Open Access   (Followers: 1)

        1 2 3 4 5 6 7 8 | Last

Similar Journals
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Annals of the RussianAacademy of Medical Sciences
Number of Followers: 0  

  This is an Open Access Journal Open Access journal
ISSN (Print) 0869-6047 - ISSN (Online) 2414-3545
Published by Paediatrician Publishers LLC Homepage  [3 journals]
  • The Prediction of Ovarian Reserve Changes after Cystectomy in Patients
           with Endometrioma Using the Point Scale System

    • Authors: Ekaterina D. Dubinskaya, Alexander S. Gasparov, Alexander A. Dutov, Mekan R. Orazov, Mukhammednazar A. Soyunov
      Pages: 5 - 12
      Abstract: Background. Ovarian endometriosis has the most aggressive effect on the ovarian reserve compared to other types of benign ovarian neoplasms. Laparoscopic cystectomy with pathomorphological verification remains the “gold standard” for the diagnosis of endometriosis in clinical practice. It is the lack of clear criteria for predicting damage to the ovarian reserve after surgical treatment and the future reproductive potential of a woman, as well as the inability to personalize treatment, that determined the purpose and objectives of this study. Aims — to develop a score scale for predicting changes in the ovarian reserve after cystectomy in ovarian endometriosis based on a comprehensive preoperative assessment of basic clinical, ultrasound, and molecular-biochemical parameters. Materials and methods. A single-center observational cohort prospective comparative study was conducted for 5 years. The study included 238 women aged 24.4 ± 3.1 years with pathomorphologically verified ovarian endometriosis, who came to the clinic with complaints of pain of varying intensity. Results. The content of anti-Muller hormone (AMH) less than 1.5 ng / ml was significantly highly correlated with the unfavorable outcome of surgery (r=0.723). The largest diameter of the formation more than 5 cm (r=0.826) and its “main” localization (r=0.743) correlated most strongly with a decrease in HR and intraovarian blood flow after cystectomy. The ROC analysis (receiver operating characteristic) and the evaluation of the area under the curve — the AUC indicator (area under ROC curve) revealed that the determining value of the “cut off” point for serum LDH was 107.35 U/l, for IL-8 — 94.55 pg/ml and IL-6 — 82.4 pg/ml, with an increase in which the probability of reducing AMH increases by more than 50%. Conclusions. The point scale system including preoperative assessment of ultrasound parameters (endometrioma size, localization, and bilaterality) and biochemical markers of toxicity in serum helps to predict changes of ovarian reserve after cystectomy (LDH, IL-6, IL-8).
      PubDate: 2022-04-18
      DOI: 10.15690/vramn1533
      Issue No: Vol. 77, No. 1 (2022)
       
  • Immunological Aspects of Normal and Pathological Pregnancy

    • Authors: Daria E. Galkina, Tatyana A. Makarenko, Dmitry V. Okladnikov
      Pages: 13 - 24
      Abstract: This article presents an overview of foreign and domestic data (Web of Science, e-LIBRARY, Scopus, PubMed) for the period 1998–2021, devoted to the system of immune protection of the mother and fetus during normal and pathologically occurring pregnancy. According to the results of the analysis of the literature data, changes occurring at the level of cellular and humoral immunity were revealed, and the mechanisms of innate and adaptive immunity, complement systems in such pathologies of pregnancy as miscarriage, threat of termination, preeclampsia, infectious complications were described. A complex system of protection against fetal rejection is a certain regulatory factor in maintaining the immunological balance during the entire gestation period, and a violation in its work underlies the formation of complications of the early and late postpartum period, as well as neonatal pathologies.
      PubDate: 2022-04-18
      DOI: 10.15690/vramn1507
      Issue No: Vol. 77, No. 1 (2022)
       
  • Etiology and Antimicrobial Resistance of Secondary Bacterial Infections in
           Patients Hospitalized with COVID-19: A Retrospective Analysis

    • Authors: Konstantin I. Karnoukh, Vladimir N. Drozdov, Evgenia V. Shikh, Svetlana V. Zhilina, Natalia B. Lazareva
      Pages: 25 - 32
      Abstract: Background. One of the complications in patients hospitalized with COVID-19 is a secondary bacterial infection. Its frequency can reach 15%, which makes it important to determine the etiology and antimicrobial resistance of the key pathogens responsible for the development of this pathology, in order to further improve the practice of prescribing and increase the effectiveness of antimicrobial chemotherapy. Aims — to assess the etiological structure and antibiotic resistance of the main pathogens of SBIs to improve the practice of antibiotic prescription. Methods. This retrospective study reviewed medical records of the patients hospitalized with COVID-19 in the Moscow city hospital No. 4 between April 28 and November 1, 2020. Demographic, clinical outcomes, etiology, and antimicrobial resistance data of the SBIs were collected. Outcomes were also compared between patients who were classified as severe and critical on admission. Results. Among 3180 patients hospitalized with COVID-19, 220 (6.9%) patients had acquired SBIs, and 50.0% of cases were fatal. The mean age was 72.7 ± 13.07 years. A higher mortality rate was observed in the group of critical patients (63%). 560 strains of bacteria isolated from the SBIs (58.8% isolated from lungs, 21% from urine and 20.2% from blood). 330 strains (58.9%) were Gram-negative bacteria. 109 patients had infections with mixed bacteria. 45 of them (20.5% of the total number of patients included in the study) had 2 pathogens, and 64 patients (29.1%) 3 or more strains. The top three bacteria of SBIs were A. baumannii (23.6%; 132/560), K. pneumoniae (22.9%; 128/560), and S. epidermidis (10.4%; 58/560). The isolation rates of carbapenem-resistant A. baumannii were 97%. Cefoperazone/sulbactam was the most active antibiotic against this pathogen with 62.1% sensitivity. Among K. pneumoniae strains, the level of resistance to carbapenems was 77.4% to meropenem and 54% to imipenem. The proportion of resistant strains to tigecycline and to colistin was 4 and 2.3% respectively. Meticillin resistance was present in 38.5% of S. aureus. 50% of E. faecium strains were vancomycin-resistant. Conclusions. Gram-negative bacteria, especially A. baumannii and K. pneumoniae, were the main pathogens, and the resistance rates of the major isolated bacteria were generally high, which indicates that more accurate use of antibacterial agents is necessary for SBIs in patients hospitalized with COVID-19.
      PubDate: 2022-04-18
      DOI: 10.15690/vramn1552
      Issue No: Vol. 77, No. 1 (2022)
       
  • Risk Factors of Transfer to Mechanical Ventilation of COVID-19 Patients in
           a Retrospective Non-Randomized Study

    • Authors: Irina A. Lakman, Timur I. Musin, Aliya R. Galiullina, Zilya A. Bagmanova, Ruslan M. Gumerov, Paruir A. Davtyan, Shamil Z. Zagidullin, Anton V. Tyurin, Sergey V. Novikov, Valentin N. Pavlov, Uilya O. Urazbakhtina, Benzhi Cai, Naufal S. Zagidullin
      Pages: 33 - 42
      Abstract: Background. The COVID-19 pandemic is associated with significant number of complications and mortality and a burden on the healthcare system. In 10–15% of hospitalized patients, the invasive and non-invasive mechanical ventilation (IMV/NIMV) is required. At the same time, it is important to stratify the risk of mechanical ventilation upon admission to the hospital. Aims — to identify clinical and laboratory risk factors for transfer to IMV and NIMV in hospitalized patients with COVID-19-associated pneumonia. Methods. A retrospective one-center nonrandomized study of 386 consecutive hospitalized patients with COVID-19-associated pneumonia was performed. The primary endpoints were IMV (n=22) and NIMV (n=28). Risk factors of artificial ventilation were considered for periods up to 14 and 28 days for both variants. To select a risk predictor, a univariate analysis based on Cox survival regression was performed, followed by multivariate analysis to determine risk factors at these time points. Results. After 28 days from admission the mortal exit was registered in 20 patients from 386 patients (5.2%). 22 patients (5.7%) were transferred to IMV, and 28 patients (7.3%) — to NIV, and 9 of the latter were transferred later to IMV. As a result of univariate and multivariate analyzes, the risk factors for transfer to mechanical ventilation on 14th day were: age > 65 years (OR=5.91), a history of stroke (OR=17.04), an increased serum level of urea (OR=6.36), LDH (OR=7.39), decreased sodium (OR=12.32), GFR <80 mL/min/1.73 m2 (OR=13.75) and platelets (OR=4.14); on the 28th day — age > 65 years (OR=4.58), J-wave on the ECG (OR=2.98), an increase of LDH (OR=9.99) and a decrease in albumin (OR=2.77) in serum. Predictors of the transfer of patients with COVID-19 to NIV within the period up to 14 days from the beginning of hospitalization were the age > 65 years (OR=5.09), procalcitonin level in the blood > 0.25 ng/ml (OR=0.19), leukocytes > 11×109 (OR=19.64) and increased LDH (OR=3.9). Conclusions. In patients with COVID-19, the risk factors for transfer to IMV/NIVL in the period of 14 and 28 days from the beginning of hospitalization were identified, which enable patient’s mechanical ventilation stratification and to plan respiratory support resources.
      PubDate: 2022-04-18
      DOI: 10.15690/vramn1673
      Issue No: Vol. 77, No. 1 (2022)
       
  • Prognostic Significance and Pathophysiological Mechanisms of Increasing
           the Levels of Cardiospecific Troponins in Biological Fluids in Arterial
           Hypertension (Literature Review)

    • Authors: Aleksey M. Chaulin
      Pages: 43 - 52
      Abstract: Improved laboratory methods for the determination of cardiac troponins (cTnT and cTnI) with increased sensitivity (hs-cTnT and hs-cTnI), recently introduced into clinical practice, have opened up a number of new promising areas for research with the aim of further expanding diagnostic capabilities for the subsequent use of hs-cTnT and hs-cTnI in modern clinical practice. It has been shown that with the use of the highly sensitive methods, even the most insignificant and reversible damage to cardiomyocytes (for example, during physical exertion, psychoemotional stress, and other conditions) is accompanied by diagnostically significant increases in hs-cTnT and hs-cTnI levels. The introduction of highly sensitive immunoassays also changed a number of ideas about the biology of cardiac troponins, for example, they are no longer considered strictly intracellular molecules, since they are determined in all healthy patients and, accordingly, they can be considered as products of normal metabolism of cardiomyocytes when they appear in blood serum in small concentrations (less than 99 percentile). In addition to the accelerated acute myocardial infarction diagnosis, hs-cTnT and hs-cTnI have a high predictive value in a number of pathological conditions that cause non-ischemic cardiomyocytes damage. Currently, the possibility of using hs-Tn in the early stages of pathogenesis of cardiovascular disease or in patients with certain risk factors (for example, arterial hypertension) to assess the risk of possible short-term and long-term adverse cardiovascular events draws an enormous interest. The purpose of this article is to analyze the prognostic significance of highly sensitive cardiospecific troponins in patients suffering from arterial hypertension, to summarize and discuss possible pathophysiological mechanisms of cardiomyocyte damage and increased levels of hs-cTnT and hs-cTnI in these patients.
      PubDate: 2022-04-18
      DOI: 10.15690/vramn1587
      Issue No: Vol. 77, No. 1 (2022)
       
  • The Impact of Medication Reconciliation on Continuityof Drug Therapy
           during Perioperative Period

    • Authors: Maria D. Nigmatkulova, E. B. Kleymenova, Liubov P. Yashina, Dmitry A. Sychev
      Pages: 53 - 61
      Abstract: Background. Medication errors and resultant adverse drug events (ADEs) often occur during transitions of care. Up to 67% of in-patients’ prescriptions have at least one unintentional medication discrepancy with previously prescribed therapy. The proportion of clinically significant medication discrepancies is 11–59%. Studies from the developed countries demonstrated the effectiveness of medication reconciliation in reducing medication errors, ADEs and healthcare resource utilization. There is a necessity to conduct medication reconciliation studies within Russian current clinical practice to develop effective medical care quality and patients’ safety programs. Aims — to evaluate the impact of pharmacologist-led medication reconciliation on the frequency and structure of unintentional medication discrepancies and potential ADEs at hospital admission and discharge. Methods. Standard care was compared to medication reconciliation led by a clinical pharmacologist in a prospective randomized trial of 410 elective surgical patients. Medication discrepancies at hospital admission and discharge were identified and reconciled. Clinical outcomes were evaluated by reviewing electronic health records. Results. In the intervention group the frequency of unintentional discrepancies at hospital admission decreased from 32.68 to 16.86%, the proportion of patients with at least one unintentional discrepancy decreased from 64.9 to 44.9%, the number of discrepancies per patient decreased from 1.5 to 0.66. The incidence of discrepancies at hospital discharge decreased from 82.90 to 43.29%, the proportion of patients with discrepancies decreased from 95.61 to 52.68%, the average number of discrepancies per patient decreased from 2.79 to 1.67. Medication reconciliation led by clinical pharmacologist decreased the frequency of unscheduled out-patient visits after discharge from 7.32 to 2.93%. The determined risk factors for unintentional discrepancies at hospital admission were: prescribing of cardiovascular, endocrine drugs and those affecting the central nervous system. Both at admission and discharge medication reconciliation was the significant factor reducing the risk of unintentional discrepancies. Conclusions. Medication reconciliation at hospital admission and discharge reduces the frequency of unintentional discrepancies in drug prescriptions by 16 and 40%, respectively. The implementation of medication reconciliation into clinical practice reduces unscheduled out-patient visits after hospital discharge.
      PubDate: 2022-04-18
      DOI: 10.15690/vramn1676
      Issue No: Vol. 77, No. 1 (2022)
       
  • Features of Drug Therapy for Patients with Ankylosing Spondylitis in
           Moscow

    • Authors: Elena S. S. Arkova, Alena I. Zagrebneva, Malwina Eva Holownia-Voloskova, Alexander G. Tolkushin
      Pages: 62 - 69
      Abstract: Background. Systematic research work on the assessment of medicines consumption allows timely identification of effective and problematic aspects of the existing system of preferential medicines provision, allowing to regulate the optimality of its functioning. Aims — to identify regional epidemiological features and key aspects of drug provision for patients with ankylosing spondylitis (AS) in Moscow in dynamics for the period 2017–2020. To identify the trend of changes and their specifics in order to optimize further preferential drug provision (DLO) for patients with AS in Moscow. Materials and methods. The sources of the study were the data of LLO of patients with AS within the outpatient care, registered in Moscow in 2017–2020. The researchers analyzed the number of patients with AS who are entitled to free and preferential drug provision, who received drugs as an outpatient link in the period 2017–2020. The age structure of beneficiaries with AS and their ratio by gender has been determined. A tendency was revealed in the distribution of patients according to the main drug therapy regimens, according to the drugs they received during the reporting period. The structure of LLO of patients with AS was revealed by international non-proprietary names of drugs, their dosage form, quantities, cost minus payment by patients. Results. A retrospective analysis of real-world data showed that the population with AS in Moscow increased by 1.5 times from 2017 to 2020, as well as the cost of expenses for LLO of these patients, excluding patient payments, also increased by 1.5 times. The average age of patients was 50±14 years in 2017, and in 2018, 2019, and 2020. This indicator increased to 51±11 years. The ratio of patients by sex was 2:1 male and female, respectively, in all periods studied. The maximum proportion of patients fell on the age group — 40–59 years, which was about 50% of the entire population of patients with AS during the entire study period. The second place was occupied by the age group 60–79 years, which accounted for 28.10% of all patients with AS in 2017 and by 2020 decreased by 3.38%, already amounting to 24.72% of patients, the third place in the number of patients belongs to the age group 30–39 years, which accounted for about 17–18% of the entire population with AS during the entire study period. The analysis of the polypharmacy indicator indicates a low drug load of most patients since a small proportion of patients — from 1.54% (20 people) to 2.71% (49 people) — had more than 10 items for international nonproprietary names per year. The leading position was occupied by the therapeutic scheme of monotherapy “NSAIDs” in 2017, since 2018 the first place belongs to the scheme of therapy with one “iTNF-α”. Conclusions. The increase in costs for the relief of adverse reactions and the treatment of concomitant diseases indicates a shift in the approach to the treatment of diseases of the musculoskeletal system, as pathologies accompanied by a wide variety of comorbid and polymorbid conditions. Despite the positive changes in the regional system of LLO of Moscow, it is possible to improve the indicators of the provision of patients with AS when evaluating its effectiveness, taking into account clinical indicators and the results of the assessment of the quality of life reported by patients.
      PubDate: 2022-04-18
      DOI: 10.15690/vramn1626
      Issue No: Vol. 77, No. 1 (2022)
       
  • To the 80th Anniversary of Academician of the Russian Academy of Sciences
           Valery Vasilievich Beregovykh

    • Authors: Editorial Board
      Pages: 70 - 70
      Abstract: February 27, 2022 marks the 80th anniversary of the birth of Academician of the Russian Academy of Sciences, Professor, Doctor of Technical Sciences, Laureate of the Prize of the Government of the Russian Federation, Deputy Academician-Secretary of the Department of Medical Sciences of the Russian Academy of Sciences Valery Vasilyevich Beregovyh.
      PubDate: 2022-04-18
      DOI: 10.15690/vramn2047
      Issue No: Vol. 77, No. 1 (2022)
       
  • To the 75th Anniversary of Academician of the Russian Academy of Sciences
           Alexander Grigorievich Rumyantsev

    • Authors: Editorial Board
      Pages: 71 - 72
      Abstract: February 12, 2022 marks the 75th anniversary of the birth of Academician of the Russian Academy of Sciences, member of the Presidium of the Russian Academy of Sciences, deputy of the State Duma of the Russian Federation of the VIII convocation, founder, CEO, president and since 2021 scientific director of the National Medical Research Center for Pediatric Hematology, Oncology and immunology them. Dmitry Rogachev» of the Ministry of Health of Russia, laureate of the Prize of the Government of the Russian Federation Alexander Grigorievich Rumyantsev.
      PubDate: 2022-04-18
      DOI: 10.15690/vramn2045
      Issue No: Vol. 77, No. 1 (2022)
       
  • To the 80th anniversary of Academician of the Russian Academy of Sciences
           Viktor Alexandrovich Tutelyan

    • Authors: Editorial Board
      Pages: 73 - 74
      Abstract: February 8, 2022 marks the 80th anniversary of the birth of the scientific director of the Federal Research Center for Nutrition, Biotechnology and Food Safety Viktor Aleksandrovich Tutelyan — the largest Russian scientist, Academician of the Russian Academy of Sciences, Doctor of Medical Sciences, Professor, Honored Scientist of the Russian Federation, laureate of the Prize of the Government of the Russian Federation in the field of science and technology.
      PubDate: 2022-04-18
      DOI: 10.15690/vramn2046
      Issue No: Vol. 77, No. 1 (2022)
       
 
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