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Global Journal of Rare Diseases
Number of Followers: 0

This is an Open Access Journal

Open Access journal
ISSN (Online) 2640-7876
Published by Peertechz

[75 journals]

Erythromelalgia: Definition, clinical contexts, differential diagnosis,
and therapy. Single case and literature update
- Abstract: Clinical publications on this morbid condition report as many as 16 different Nav1 7 channel substitutions. They also report more than 40 pharmacological treatments, including agents with sodium channel blocking but nonspecific activity (mexiletine, lidocaine, carbamazepine), anti-neuropathic drugs (gabapentinoids and antidepressants), antidepressant drugs with efficacy on migraines (amitriptyline) vasoactive drugs for the management of hypertension, and analgesics (opioids and ketamine). Current research fails to address all patients’ clinical needs, although it recently suggests new genetic hypotheses yet to be tested and the central importance of genetic counseling, to inform patients and their families about the severity, likely course of symptoms, and risk of complications, and in some cases to guide clinical management. Current findings and the significant morbidity associated with the condition, even in light of the single case presented, highlight the need for mechanism-based therapies to improve clinical outcomes.
  PubDate: 12 Apr, 2022
Delayed splenic rupture 4 months following minor blunt abdominal
traumaChatzipetrou Maria, Tzanakis Nickolaos, Giannopoulos George and
Kornaropoulos Michail*
- Abstract: Splenic rupture, no matter what the cause is, is associated with significant mortality. It can present either acutely after trauma, or days to weeks later, a situation known as ‘’delayed splenic rupture (DSR)’’. On the other hand, splenic rupture without trauma history occurs mainly in a pathologically altered spleen, a rare situation called atraumatic splenic rupture (ASR). Cases of ASR of normal spleen have been reported in literature with various cause as far as trauma is concerned.
  PubDate: 13 May, 2021
Diabetes and COVID-19, potentialities of Morus alba L. (mulberry) and
Stevia rebaudiana Bertoni (stevia). Mini-review
- Abstract: Diabetes mellitus is one of the main comorbidities associated with mortality and severe disease in infections with SARS-CoV-2. Extracts from the leaves of Morus alba and Stevia rebaudiana are used in traditional medicine to control diabetes. A brief review is made of the potential of these extracts to improve the conditions associated with COVID-19, not only through the control of diabetes but also for the presence of chemical compounds, particularly flavonoids, which have shown antiviral activity in pharmacological and in silico studies.
  PubDate: 10 Aug, 2021
Time to pay attention: Elder abuse in the COVID-19 Pandemic Era
- Abstract: COVID 19 pandemic has presented an opportunity for health care providers to expand their understanding of risks of using neglectful or abusive behavior to the elder during this time, and consider incorporating studies related to this challenge. Individuals experiencing caregiving concern and stress about whether their loved ones’ needs will be met should be considered. They should be more open to share their uncomfortable experiences. Being aware of the problems of older adults and their caregivers is critical to helping them thrive and survive during this pandemic. Addressing increased risks, attending to mental health needs, and connecting older adults to caregiving and providing financial resources can all help the old patients and their loved ones to avoid violent and abusive situations and be safer.
  PubDate: 01 Jul, 2021

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