Subjects -> MEDICAL SCIENCES (Total: 8212 journals)
    - ALLERGOLOGY AND IMMUNOLOGY (205 journals)
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    - CARDIOVASCULAR DISEASES (334 journals)
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    - COMMUNICABLE DISEASES, EPIDEMIOLOGY (227 journals)
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    - HYPNOSIS (4 journals)
    - INTERNAL MEDICINE (177 journals)
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    - MEDICAL GENETICS (58 journals)
    - MEDICAL SCIENCES (2241 journals)
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    - OBSTETRICS AND GYNECOLOGY (199 journals)
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    - SPORTS MEDICINE (77 journals)
    - SURGERY (388 journals)
    - UROLOGY, NEPHROLOGY AND ANDROLOGY (151 journals)

MEDICAL SCIENCES (2241 journals)                  1 2 3 4 5 6 7 8 | Last

Showing 1 - 200 of 3562 Journals sorted alphabetically
16 de Abril     Open Access   (Followers: 1)
3D Printing in Medicine     Open Access   (Followers: 5)
4 open     Open Access  
AADE in Practice     Hybrid Journal   (Followers: 2)
AAS Open Research     Open Access  
ABCS Health Sciences     Open Access   (Followers: 3)
Abia State University Medical Students' Association Journal     Full-text available via subscription   (Followers: 1)
AboutOpen     Open Access  
ACIMED     Open Access  
ACM Transactions on Computing for Healthcare     Hybrid Journal  
ACS Medicinal Chemistry Letters     Hybrid Journal   (Followers: 42)
Acta Bio Medica     Open Access   (Followers: 1)
Acta Bioethica     Open Access  
Acta Bioquimica Clinica Latinoamericana     Open Access   (Followers: 1)
Acta Herediana     Open Access  
Acta Marisiensis - Seria Medica     Open Access  
Acta Medica (Hradec Králové)     Open Access  
Acta Medica Bulgarica     Open Access  
Acta Medica Colombiana     Open Access   (Followers: 1)
Acta Médica Costarricense     Open Access   (Followers: 2)
Acta Medica Indonesiana     Open Access  
Acta Medica International     Open Access  
Acta Medica Iranica     Open Access  
Acta medica Lituanica     Open Access  
Acta Medica Martiniana     Open Access  
Acta Medica Peruana     Open Access   (Followers: 1)
Acta Scientiarum. Health Sciences     Open Access   (Followers: 2)
Acupuncture & Electro-Therapeutics Research     Full-text available via subscription   (Followers: 3)
Acupuncture and Herbal Medicine     Open Access   (Followers: 1)
Addiction Science & Clinical Practice     Open Access   (Followers: 9)
Addictive Behaviors Reports     Open Access   (Followers: 8)
Adıyaman Üniversitesi Sağlık Bilimleri Dergisi / Health Sciences Journal of Adıyaman University     Open Access  
Adnan Menderes Üniversitesi Sağlık Bilimleri Fakültesi Dergisi     Open Access  
Advanced Health Care Technologies     Open Access   (Followers: 12)
Advanced NanoBiomed Research     Open Access   (Followers: 1)
Advanced Science, Engineering and Medicine     Partially Free   (Followers: 4)
Advanced Therapeutics     Hybrid Journal   (Followers: 1)
Advances in Bioscience and Clinical Medicine     Open Access   (Followers: 6)
Advances in Cell and Gene Therapy     Hybrid Journal   (Followers: 1)
Advances in Clinical Chemistry     Full-text available via subscription   (Followers: 24)
Advances in Clinical Radiology     Full-text available via subscription   (Followers: 4)
Advances in Life Course Research     Hybrid Journal   (Followers: 7)
Advances in Medical Education and Practice     Open Access   (Followers: 29)
Advances in Medical Sciences     Hybrid Journal   (Followers: 7)
Advances in Medicine     Open Access   (Followers: 3)
Advances in Microbial Physiology     Full-text available via subscription   (Followers: 3)
Advances in Parkinson's Disease     Open Access   (Followers: 2)
Advances in Preventive Medicine     Open Access   (Followers: 6)
Advances in Protein Chemistry and Structural Biology     Full-text available via subscription   (Followers: 18)
Advances in Regenerative Medicine     Open Access   (Followers: 3)
Advances in Therapy     Hybrid Journal   (Followers: 5)
Advances in Traditional Medicine     Hybrid Journal   (Followers: 3)
Advances in Virus Research     Full-text available via subscription   (Followers: 7)
Advances in Wound Care     Hybrid Journal   (Followers: 14)
Aerospace Medicine and Human Performance     Full-text available via subscription   (Followers: 22)
African Health Sciences     Open Access   (Followers: 6)
African Journal of Biomedical Research     Open Access  
African Journal of Clinical and Experimental Microbiology     Open Access  
African Journal of Laboratory Medicine     Open Access   (Followers: 2)
African Journal of Medical and Health Sciences     Open Access  
Afrimedic Journal     Open Access   (Followers: 3)
AIDS Research and Human Retroviruses     Hybrid Journal   (Followers: 9)
Airway     Open Access   (Followers: 3)
AJOB Empirical Bioethics     Hybrid Journal   (Followers: 3)
AJSP: Reviews & Reports     Hybrid Journal  
Aktuelle Ernährungsmedizin     Hybrid Journal   (Followers: 4)
AkupunkturPraxis     Full-text available via subscription   (Followers: 3)
Al-Azhar Assiut Medical Journal     Open Access   (Followers: 1)
Al-Qadisiah Medical Journal     Open Access  
Alerta : Revista Científica del Instituto Nacional de Salud     Open Access  
Alexandria Journal of Medicine     Open Access  
Allgemeine Homöopathische Zeitung     Hybrid Journal   (Followers: 1)
ALTEX : Alternatives to Animal Experimentation     Open Access   (Followers: 1)
American Journal of Biomedical Engineering     Open Access   (Followers: 10)
American Journal of Biomedical Research     Open Access   (Followers: 2)
American Journal of Biomedicine     Full-text available via subscription  
American Journal of Chinese Medicine, The     Hybrid Journal   (Followers: 2)
American Journal of Clinical Medicine Research     Open Access   (Followers: 5)
American Journal of Family Therapy     Hybrid Journal   (Followers: 6)
American Journal of Law & Medicine     Full-text available via subscription   (Followers: 10)
American Journal of Lifestyle Medicine     Hybrid Journal   (Followers: 5)
American Journal of Managed Care     Full-text available via subscription   (Followers: 13)
American Journal of Medical Case Reports     Open Access  
American Journal of Medical Sciences and Medicine     Open Access   (Followers: 2)
American Journal of Medicine     Hybrid Journal   (Followers: 47)
American Journal of Medicine and Medical Sciences     Open Access   (Followers: 1)
American Journal of Medicine Open     Open Access   (Followers: 3)
American Journal of Medicine Studies     Open Access   (Followers: 3)
American Journal of Medicine Supplements     Full-text available via subscription   (Followers: 3)
American Journal of the Medical Sciences     Hybrid Journal   (Followers: 11)
American Journal on Addictions     Hybrid Journal   (Followers: 11)
American medical news     Free   (Followers: 3)
Amrita Journal of Medicine     Open Access   (Followers: 3)
Amyloid: The Journal of Protein Folding Disorders     Hybrid Journal   (Followers: 6)
Anales de la Facultad de Medicina     Open Access  
Anales de la Facultad de Medicina, Universidad de la República, Uruguay     Open Access  
Anales del Sistema Sanitario de Navarra     Open Access   (Followers: 1)
Analgesia & Resuscitation : Current Research     Hybrid Journal   (Followers: 5)
Anatolian Clinic the Journal of Medical Sciences     Open Access  
Anatomica Medical Journal     Open Access  
Anatomical Science International     Hybrid Journal   (Followers: 3)
Anatomical Sciences Education     Hybrid Journal   (Followers: 1)
Anatomy     Open Access   (Followers: 3)
Anatomy Research International     Open Access   (Followers: 4)
Androgens : Clinical Research and Therapeutics     Open Access  
Angewandte Nuklearmedizin     Full-text available via subscription   (Followers: 3)
Angewandte Schmerztherapie und Palliativmedizin     Hybrid Journal  
Angiogenesis     Hybrid Journal   (Followers: 2)
Animal Diseases     Open Access   (Followers: 1)
Annales de Pathologie     Full-text available via subscription  
Annales françaises d'Oto-rhino-laryngologie et de Pathologie Cervico-faciale     Full-text available via subscription   (Followers: 2)
Annals of 3D Printed Medicine     Open Access  
Annals of African Medicine     Open Access   (Followers: 2)
Annals of Anatomy - Anatomischer Anzeiger     Hybrid Journal   (Followers: 2)
Annals of Biomedical Engineering     Hybrid Journal   (Followers: 18)
Annals of Biomedical Sciences     Full-text available via subscription   (Followers: 3)
Annals of Clinical and Medical Case Reports     Open Access  
Annals of Clinical Hypertension     Open Access  
Annals of Clinical Microbiology and Antimicrobials     Open Access   (Followers: 9)
Annals of Family Medicine     Open Access   (Followers: 14)
Annals of Health Research     Open Access   (Followers: 2)
Annals of Ibadan Postgraduate Medicine     Open Access  
Annals of Medical and Health Sciences Research     Open Access   (Followers: 5)
Annals of Medicine     Hybrid Journal   (Followers: 11)
Annals of Medicine and Surgery     Open Access   (Followers: 7)
Annals of Medicine and Surgery Case Reports     Open Access   (Followers: 1)
Annals of Medicine and Surgery Protocols     Open Access  
Annals of Microbiology     Open Access   (Followers: 9)
Annals of Musculoskeletal Medicine     Open Access  
Annals of Rehabilitation Medicine     Open Access   (Followers: 1)
Annals of Saudi Medicine     Open Access  
Annals of the College of Medicine, Mosul     Open Access  
Annals of the National Academy of Medical Sciences (India)     Open Access  
Annals of the New York Academy of Sciences     Hybrid Journal   (Followers: 5)
Annals of The Royal College of Surgeons of England     Full-text available via subscription   (Followers: 3)
Annals of the RussianAacademy of Medical Sciences     Open Access  
Annals of Vascular Surgery - Brief Reports and Innovations     Full-text available via subscription  
Annual Reports in Medicinal Chemistry     Full-text available via subscription   (Followers: 6)
Annual Reports on NMR Spectroscopy     Full-text available via subscription   (Followers: 4)
Annual Review of Medicine     Full-text available via subscription   (Followers: 18)
Anthropological Review     Open Access   (Followers: 27)
Anthropologie et santé     Open Access   (Followers: 4)
Antibiotics     Open Access   (Followers: 10)
Antibodies     Open Access   (Followers: 2)
Antibody Reports     Open Access  
Antibody Therapeutics     Open Access  
Anuradhapura Medical Journal     Open Access  
Anwer Khan Modern Medical College Journal     Open Access  
Apmis     Hybrid Journal   (Followers: 1)
Apparence(s)     Open Access   (Followers: 1)
Applied Clinical Informatics     Hybrid Journal   (Followers: 4)
Applied Medical Informatics     Open Access   (Followers: 11)
Arab Journal of Nephrology and Transplantation     Open Access   (Followers: 2)
Arabian Journal of Scientific Research / المجلة العربية للبحث العلمي     Open Access  
Archive of Biomedical Science and Engineering     Open Access  
Archive of Clinical Medicine     Open Access   (Followers: 1)
Archives Medical Review Journal / Arşiv Kaynak Tarama Dergisi     Open Access  
Archives of Asthma, Allergy and Immunology     Open Access   (Followers: 1)
Archives of Clinical Hypertension     Open Access  
Archives of Medical and Biomedical Research     Open Access   (Followers: 2)
Archives of Medical Laboratory Sciences     Open Access  
Archives of Medicine and Health Sciences     Open Access   (Followers: 5)
Archives of Organ Transplantation     Open Access  
Archives of Preventive Medicine     Open Access  
Archives of Pulmonology and Respiratory Care     Open Access  
Archives of Renal Diseases and Management     Open Access  
Archives of Trauma Research     Open Access   (Followers: 4)
Arquivos de Medicina     Open Access  
Ars Medica : Revista de Ciencias Médicas     Open Access  
ARS Medica Tomitana     Open Access  
Art Therapy: Journal of the American Art Therapy Association     Hybrid Journal   (Followers: 14)
Arterial Hypertension     Open Access  
Artificial Intelligence in Medicine     Hybrid Journal   (Followers: 19)
Artificial Organs     Hybrid Journal   (Followers: 1)
ASA Monitor     Full-text available via subscription   (Followers: 1)
Asia Pacific Journal of Clinical Nutrition     Full-text available via subscription   (Followers: 10)
Asian Bioethics Review     Full-text available via subscription   (Followers: 2)
Asian Journal of Cell Biology     Open Access   (Followers: 4)
Asian Journal of Health     Open Access   (Followers: 3)
Asian Journal of Medical and Biological Research     Open Access   (Followers: 3)
Asian Journal of Medical and Pharmaceutical Researches     Open Access  
Asian Journal of Medical Sciences     Open Access   (Followers: 2)
Asian Journal of Medicine and Health     Open Access   (Followers: 1)
Asian Journal of Population Sciences     Open Access   (Followers: 1)
Asian Journal of Research in Medical and Pharmaceutical Sciences     Open Access  
Asian Journal of Scientific Research     Open Access   (Followers: 2)
Asian Journal of Social Health and Behavior     Open Access   (Followers: 3)
Asian Journal of Transfusion Science     Open Access  
Asian Medicine     Hybrid Journal   (Followers: 5)
Asian Pacific Journal of Health Sciences     Open Access   (Followers: 2)
ASPIRATOR : Journal of Vector-borne Disease Studies     Open Access  
Atención Primaria     Open Access   (Followers: 2)
Atención Primaria Práctica     Open Access  
Atti della Accademia Peloritana dei Pericolanti - Classe di Scienze Medico-Biologiche     Open Access  
Auris Nasus Larynx     Full-text available via subscription  
Australasian Journal of Ultrasound in Medicine (AJUM)     Hybrid Journal   (Followers: 1)
Australian Family Physician     Full-text available via subscription   (Followers: 3)
Australian Journal of Medical Science     Full-text available via subscription   (Followers: 4)
Autopsy and Case Reports     Open Access  
Avicenna     Open Access   (Followers: 1)

        1 2 3 4 5 6 7 8 | Last

Similar Journals
Journal Cover
Advances in Traditional Medicine
Number of Followers: 3  
 
  Hybrid Journal Hybrid journal (It can contain Open Access articles)
ISSN (Print) 2662-4052 - ISSN (Online) 2662-4060
Published by Springer-Verlag Homepage  [2469 journals]
  • Development of antibacterial nanofibrous wound dressing and conceptual
           reaction mechanism to deactivate the viral protein by Nigella sativa
           extract

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      Abstract: Nigella sativa (N. sativa) is extensively used as medicinal plant all over the world. It has the potential properties as the antiviral and antibacterial application. Its seed contain thymoquinone (TQ), thymohydroquinone (THQ), thymol (THY), p-cymene as major and other minor components. TQ and THQ exhibit broad spectrum of antimicrobial properties against the activity of bacteria, viruses, parasites, schistosoma and fungi. This work provides credence to the fabrication of antibacterial nanofibrous membrane by electrospinning machine from N. sativa extract with polyvinyl alcohol (PVA) solution for wound dressing. The morphology of the developed membrane is also characterized using scanning electron microscope. Fourier transform infrared spectroscopy (FTIR) data has been showed that the functional groups of N. sativa are present in the prepared PVA-N. sativa nanofibrous membrane and its antibacterial activity was investigated. The disk diffusion method has been used to evaluate the antibacterial activity of PVA-N. sativa nanofibrous membrane against Staphylococcus aureus (S. aureus) bacteria and the inhibition zone with a value of 10 mm is formed. Considering the inherent properties of N. sativa, a conceptual reaction mechanism has been proposed to deactivate the viral proteins by the action of TQ and THQ.
      PubDate: 2022-06-01
       
  • Ethnobotanical research in Sürmene district (Trabzon-Turkey, Black
           Sea Region)

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      Abstract: Traditional knowledge of plants is inter-generationally transferred. It is important to keep proper records in order to avoid the loss of the ethnobotanical heritage. This study is an ethnobotanical survey conducted in Sürmene district in the Black Sea Region of Trabzon-Turkey. The study was conducted between 2018 and 2019. Plants were collected from different altitudes in the district. The required information was collected through ethnobotanical interviews with local people. Use value of species was determined and informant consensus factor was calculated for medicinal plants included in the study. In this study, eighty-two taxa belonging to 42 families were identified. Sixty-six of them are natural, while 16 of them are cultivated plants. One of the species is endemic, Anthemis melanoloma subsp. trapezuntica Grierson. Of the collected plants, 54 taxa are used for medical purposes, 31 is used for food, 17 is used for animal fodder, 16 is used as fuel, 3 is used as honey plant, 2 is used as organic fertilizers, and 16 is used for different purposes. Most of the plants used in the district belong to the families Asteraceae (11 species), Rosaceae (9 species), Lamiaceae (6 species), Poaceae (4 species), and Ericaceae (4 species). Of all the medicinal plants, Citrus sinensis, Actinidia deliciosa, Mentha × piperita, and Thymus nummularius seem are well-known to the locals, as indicated by their high UV. In conclusion, this study collected information regarding the traditional uses of plants in Sürmene district and also helped to preserve the valuable information. Ethnobotanical studies are increasing the possibilities of identifying new molecules; thus, this study may serve as a basis for future pharmacological and phytochemical studies which could lead to the discovery and development of new pharmaceuticals.
      PubDate: 2022-06-01
       
  • Protective effect of Prunus amygdalus nut extract on chronic unpredictable
           stress (CUS) induced memory deficits and biochemical alterations in rats

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      Abstract: Stress intervenes in the brain’s capability to encode and regain information from a person, it alters the biochemical parameters in specific regions of the brain can cause long-term damage to various parts of brain. The present investigations aid in understanding the effect of the Prunus amygdalus nut extract on CUS induced memory deficits in rats. The methanolic extract with an antioxidant potential (~ 60%) and was selected for in vivo analysis. CUS was induced in rats using different stress paradigms for 10 days. On day 11 and 12, acquisition trials for memory evaluation were performed using Morris Water Maze. On day 13 and 10 days later on, i.e. day 23, short-term and long-term memory retrievals trials were evaluated, respectively. Treatment groups were given test methanolic extract an hour before the subjection of CUS. Biochemical estimations and histopathological studies were carried out using brain tissue homogenate and brain tissue section, respectively. CUS altered the Transfer Latency time in both acquisition and retrieval trials, indicating memory impairment, which was reduced significantly in extract-treated groups. Administration of P. amygdalus nut methanolic extract protected the rat brains against CUS-induced neuroinflammatory changes. The observed beneficial effects could be attributed to the antioxidant potential of P. amygdalus. Graphic abstract
      PubDate: 2022-06-01
       
  • Olax psittacorum (Lam.) Vahl. (Olacaceae): current status and future
           prospects as an herbal plant

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      Abstract: Olax psittacorum (Lam.) Vahl. traditionally used by the tribal community of ‘INDIA’ to heal conditions such as pain, psoriasis, mouth-ulcer, anemia, constipation as well as diabetes. Documented scientific shreds of evidence like antipyretic, anti-inflammatory, antimicrobial, anti-viral, anti-cancer, toxicity profile improved its medicinal value. Chromatographic evaluation (GC–MS) proven near about presence of 25 compounds. Among them, hexadecanoic methyl ester, β-sitosterol, phytol, methyl salicylate, 13-docosenamide, and oleanolic acid are significant and contribute to its successful medicinal properties. The toxicity study also revealed the safety of the consumption of the leaf part. Still, consecutive gaps need to be exploring to gather evidence of its contribution to curing different ailments, especially upon the ulcer, anemia, and identification of the presence of lead compounds as an upcoming future research proposal. The ‘Internet Scholar’, ‘Study Guide’, ‘PubMed’, ‘ScienceDirect’, ‘Scopus’, and ‘Sodhganga’ web site have been accessed to gather information about detailed scientific research as well as traditional information from authenticated sources that have been published in the English language. The various folklore claimed medicinal properties like anti-ulcer, aphthous ulcer, analgesic, anti-diabetic, anti-anemic, etc. yet to be justified scientifically with lead compounds that can support the rationality being used as folklore. This plant could be a good choice to explore its importance within the pharmacognostic field of drug development and might be a better source of herbal derived lead compounds which can help to heal ulcer or anemia that can effectively make a credible addition to treatment among the civilization as a natural source of therapeutic compounds.
      PubDate: 2022-06-01
       
  • Tetrorchidium didymostemon leaf extract reduces Plasmodium berghei
           induced oxidative stress and hepatic injury in Swiss albino mice

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      Abstract: Oxidative stress, already implicated in malaria infection has been identified as one of the major contributors to the pathophysiology of malaria. This study was aimed at evaluating the effects of methanol extracts of Tetrorchidium didymostemon leaf and stem bark on Plasmodium berghei induced oxidative stress in the liver, spleen and brain of mice. P. berghei-infected mice were sacrificed on day 5 of the experiment after four days of consecutive administration of T. didymostemon extracts (250 and 500 mg/kg body weight). Thereafter, biochemical analysis and histopathological examination were carried out. The leaf extract had a significantly higher (P < 0.05) ability to reduce parasite induced alterations of antioxidant enzyme activities compared with the stem bark extract. Malondialdehyde level was significantly higher (P < 0.05) while glutathione peroxidase and catalase activities were lower in the negative control (infected mice, without treatment) relative to the treated groups. The leaf extract at 500 mg/kg body weight had a higher ability to ameliorate changes in oxidative stress and reduce hepatic injury induced by P. berghei in comparison with the other doses. The leaf extract (500 mg/kg) was able to reduce significantly hepatomegaly induced by P. berghei. Similarly, histopathological observation of the organs (liver and spleen) shows relative reversal of the cellular and morphological alteration induced by P. berghei infection following leaf extract administration. Our study suggests that treatment of P. berghei infected mice with T. didymostemon leaf extract during early infection reduces oxidative stress by preventing lipid peroxidation and normalizing glutathione peroxidase and catalase activities.
      PubDate: 2022-06-01
       
  • Potential bioactive molecules from natural products to combat against
           coronavirus

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      Abstract: Covid-19 is terribly spreading around the globes and there is no stoppage. It is causing mass destruction in mankind allowing them to lock inside home to contain the disease. At present, there are no remedial medicines, drugs, or vaccines available in the market. Researchers are trying their best level to produce drugs to fight againts the disease. Various efforts are being considered by using different directions of scientific knowledge and technologies on treating the disease. The existing antiviral drugs such as lopinavir/ritonavir, pitavastatin, nelfinavir, perampanel, and praziquantel are being administered as remedies of covid-19 patients. Unfortunately, none of these drugs works absolutely against the current pandemic. Therefore, bioactive molecules from plants, animals, and microorganisms could be a better option to treat against the covid-19 and its family. Plants can treat many diseases due to the presence of bioactive molecules and their antiviral properties. Presence of secondary metabolites such as flavonoids, alkaloids, terpenoids, polyphenols, curcumin, kaempferol, catechin, naringenin, quercetin, apigenin-7-glucoside, luteolin-7-glucoside, demethoxycurcumin, oleuropein, and epigallocatechin can fight against the coronavirus including covid-19. The listed plants such as litchi seeds, Houttuynia cordata, Chinese Rhubarb extracts, beta-sistosterol from Isatis indigotica root extract have capacity to obstruct the enzymatic activity of SARS. In this article, we have highlighted the bioactive molecules from different plants, animals, and microorganism and their potential activity against the coronavirus. It is a need of the hour to come together to explore more on such bioactive compounds of plants, animals and other microorganism to fight against the covid-19.
      PubDate: 2022-06-01
       
  • Optimization of plant compositions of Trisattakula to maximize
           antibacterial activity and formulation development of film-forming
           polymeric solution containing Nigella sativa ethanolic extract

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      Abstract: The Trisattakula herbal recipe has been used for a long time for the treatment of the symptom of the gastrointestinal tract. Based on the plant compositions, it exhibits antibacterial activity. This work sought to optimize the mass ratios of plant compositions of Trisattakula recipe (equal mass ratios of dried seeds of Nigella sativa L., dried fruits of Coriandrum sativum L., and fresh rhizomes of Zingiber officinale Roscoe) to maximize the anti-Staphylococcus aureus and anti-S. epidermidis activities. The simplex lattice design was applied in the optimization process. Results showed that dried seeds of N. sativa alone gave the highest extraction yield, and the extract of dried seeds of N. sativa alone exhibited the most potent antibacterial activity. The ethanolic extract of dried seeds of N. sativa was further used as an active ingredient of film-forming polymeric solution (FFPS). The three film-forming agents, including hydroxypropyl methylcellulose E5, xanthan gum, and Eudragit® RL 30D, were used. However, 5% hydroxypropyl methylcellulose E5 blended 0.5% xanthan gum FFPS system containing 9.2% N. sativa extract was the best formulation. It showed good antibacterial activity against both S. aureus and S. epidermidis. The release of thymoquinone determined using validated high-performance liquid chromatography approached the Korsmeyer-Peppas model. In summary, the FFPS containing N. sativa extract could be used as an alternative antibacterial product for the treatment of skin infection caused by the two pathogens: S. aureus and S. epidermidis.
      PubDate: 2022-06-01
       
  • Baccaurea ramiflora Lour.: a comprehensive review from traditional usage
           to pharmacological evidence

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      Abstract: Baccaurea ramiflora Lour. syn. Baccaurea sapida (Roxb.) Muell. Arg. widely known as Burmese grape is native to Southeast Asia. Its leaves, fruits, stem, bark, seeds forms an ingredient in many herbal prescriptions which have been used to treat jaundice, constipation, indigestion, cellulitis, as antidote for sanke venome, antiphlogistic and anodyne against rheumatoid arthritis etc. In the recent years, this plant has been largely explored on scientific grounds to identify the chemical constituents and pharmacological activities. The present review work is an effort to revisit the scientific works done to evaluate the scope for bioprospection of B. ramiflora. Based on the study designed, a number of research papers were reviewed, but only about 35 articles having information on B. ramiflora were evaluated in detail. In total, thirty compounds have been isolated and characterised so far from different parts of this evergreen tree, which accounts for its myriad medicinal value including analgesic, anthelmintic, antioxidant, anti-diarrheal, anti-inflammatory, cytotoxic, haemolytic, hypoglycemic, hypolipidemic, insecticidal, neuropharmacological, thrombocytic, anti-fungal and antimicrobial activities. This compilation of assorted information underpins the basic perceptive of B. ramiflora and opens up new horizon for further phytochemical evaluation, safety efficacy, and clinical trials.
      PubDate: 2022-06-01
       
  • Algerian Sonchus oleraceus L.: a comparison of different extraction
           solvent on phytochemical composition, antioxidant properties and
           anti-cholinesterase activity

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      Abstract: Aerial parts of Sonchus oleraceus L. were studied for the antioxidant and anti-cholinesterase activities in different solvent and fractions. Extracts/fractions were analysed for total phenolic, flavonoid and flavonol contents. The chemical constituents of the most active extracts/fractions were analysed using LC–MS/QTOF in the positive ion mode. Ethyl acetate and butanolic fractions exhibited the highest antioxidant activity in DPPH, galvinoxyl and phenanthroline assays due to high contents of phenolics, flavonoids and flavonols. Whereby total alkaloid extract had the highest scavenging activity in ABTS•+ assay. Besides, methanolic extract was noted for the highest inhibitory effect against acetylcholinesterase. Total 24 compounds were identified by LC–MS/QTOF which were phenolic acids, sesquiterpene lactones and phenylpropanoid derivatives. As conclusion, the study revealed that the aerial parts of S. oleraceus are potential sources of natural antioxidant and anti-cholinesterase compounds.
      PubDate: 2022-06-01
       
  • Bioactivity assessment of ethanolic extracts from Theobroma cacao and Cola
           spp. wastes after solid state fermentation by Pleurotus ostreatus and
           Calocybe indica

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      Abstract: The use of agro-industrial residues for production of bio-functional products has aroused the interest of scientists as a positive step towards ecological sustainable. In this study, Pleurotus ostreatus or Calocybe indica was used in solitary and were combined in solid state fermentation to improve bioactivities of extracts from cocoa pod husk (CPH) and kolanut pod (KP). The bioactive compounds in extracts were revealed using Gas chromatography–mass spectrometry (GCMS). Phenolic and flavonoid contents of studied extracts were within 34.80–56.9 mg/g Gallic acid equivalent and 11.50–31.5 mg/g Quercertin equivalent, respectively. Extracts from unfermented and fermented pods of Theobroma cacao and Cola spp. displayed notable antimicrobial activity against indicator microorganisms with zones of inhibition ranged from 5.0 to 18.0 mm. Minimum inhibitory concentration of the extracts against microorganisms ranged from 2.5 to 10.0 mg/ml. IC50 of extracts against free radicals ranged from 0.3 to 1.7 mg/ml, 0.4–1.7 mg/ml and 0.4–1.8 mg/ml for DPPH, Fe and OH−, respectively. Some of bioactive compounds identified using GCMS were phenol, glycerine, pimelic ketone, D-ribonic acid, methyl myristate, palmitic acid methyl ester, oleic acid ethyl ester, lauramide, oleic acid amide, 1,2-cyclododecanediol, resorcinol, phytol and others. The bioactivities of extracts from unfermented and fermented CPH and KP can be attributed to the presence of assorted bioactive compounds, which can be exploited as antimicrobial, antioxidant, anti-inflammatory, immunomodulatory, antitumor promoting agents and therefore, useful for production of functional foods, pharmaceuticals, and cosmetics.
      PubDate: 2022-06-01
       
  • Evaluation of the extraction process of Arenaria hispanica L. using
           response surface methodology on amounts of total phenolic content, total
           flavonoid content and the antioxidant activity

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      Abstract: The selection of appropriate conditions for increasing the extraction efficiency is important. The response surface method (RSM) is a statistical and mathematical technique which it can be used to examine the dependence between the responses with variables in a process and also determine the optimal conditions. In this study, the experimental design of General full factorial (GFF) was used by Minitab 17 software. The variables were time (30, 60 and 90 min), solvent (water, methanol and n-hexane) and method (maceration and ultrasound-assisted extraction). The main effects and also interaction terms were investigated on amounts of total phenolic content (TPC), total flavonoid content (TFC) and the antioxidant activity (according to DPPH, FRAP, IC50 and BCB) of extract of Arenaria hispanica L.. A multiple regression, first degree model was used to express the responses. An analysis of variance (ANOVA) with 95% confidence level was then carried out for each response (TPC, TFC, FRAP, IC50 and BCB) in order to test the model significance and suitability. In optimum conditions, the maceration method was optimum method for TPC, FRAP and BCB, while for TFC was ultrasound-assisted extraction. Water was optimal solvent for TPC, FRAP and BCB, but methanol was obtained as the best solvent for TFC and IC50. Also, the extraction time of TPC was 60 min and for TFC, IC50, FRAP and BCB obtained 30 min. The mounts of TPC, TFC, IC50, FRAP and BCB in the optimum conditions obtained 173.93 ± 0.50 (mg GAE/g extract), 184.27 ± 4.04 (mg QC/g extract), 0.69 ± 0.03 (mg/mL), 734.80 ± 2.02 (mmol Fe2+/g exctract) and 21.23 ± 0.22; respectively.
      PubDate: 2022-06-01
       
  • Influence of harvest season and different polarity solvents on biological
           activities, phenolic compounds and lipid-soluble pigment contents of
           Spirogyra sp. from Algeria

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      Abstract: Effects of extraction solvent and harvest period on phytochemical analysis and antioxidant and antimicrobial activities of extracts obtained from the freshwater macroalga, Spirogyra sp. were evaluated. The experiment lasted five months, where five crude extracts were obtained by maceration using different solvents: hexane, chloroform, dichloromethane, acetone and methanol. Higher values of yields were recorded in methanolic extracts on February (7.304%) and March (4.812%). All extracts were rich in proanthocyanidins compared to total phenolics and flavonoids. The total amounts of carotenoids were very low (0.060 ± 0001 to 0.171 ± 0.005 mg/g) compared to chlorophylls which were higher in February (6.365 ± 0.075 mg/g) and in March (5.501 ± 0.118 mg/g). The antioxidant activities indicated that the chloroformic and dichloromethanic extracts of February and March exhibited a good activity. The correlation using the Pearson test of phenolic compounds and antioxidant activity tests have confirmed the strong contribution of flavonoids and proanthocyanidins. The greatest antimicrobial activity was found in hexanic extracts at 0.1 to 1 mg/disk. The present findings suggest that Spirogyra sp. can be exploited not only for human health, but also for screening new economic natural antioxidants that could be used in foods, cosmetics and pharmaceutical industries.
      PubDate: 2022-06-01
       
  • Nephroprotective effect of Sphaeranthus amaranthoides Burm f.:
           Sivakaranthai (a Siddha Kayakalpa drug) against gentamicin induced
           nephrotoxicity

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      Abstract: Acute kidney injury (AKI) is described as a disorder with a sudden loss of kidney function. AKI is also attributed to several aetiologies such as diabetes, cardiac problems, etc. Developing a therapy for AKI is challenging due to its complex pathophysiology. The present study investigated the effect of Sphaeranthus amaranthoides Burm f. aqueous extract, a Siddha Kalpha drug, against gentamicin-induced AKI. Animals were initially pre-administered with different concentrations of S. amaranthoides and later induced with gentamicin on the 8th day. Biochemical, anti-inflammatory and antioxidant markers were analysed. Further, HRLCMS analysis was carried out to identify the bioactive components. Components including myo-inositol, traumatic acid, rosmarinic acid, etc. were identified. In the animals induced with gentamicin, KIM1, LDH, GGT, creatinine, BUN and electrolytes were elevated in both serum and urine, while noted within normal range in S. amaranthoides pre-administered groups. Histopathology analysis revealed prevention of necrosis, tubular epithelial cell degeneration and glomerular congestion in S. amaranthoides administered animals. Lipid peroxidation, KIM1, Cystatin C, TNFα, IL6 and NFκB were within normal range in tissues. Thus, it is evident that S. amaranthoides is effective in protecting kidney damage and treating AKI. Further studies will be conducted to analyse the pathways resurrecting kidney damage.
      PubDate: 2022-06-01
       
  • Effect of Anthonotha macrophyla (P. Beauv) leaf extract on
           carrageenan-induced paw oedema, oxidative stress makers and hyperalgesia
           in murine models

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      Abstract: Anthonotha macrophylla leaf (AML) is employed in the management of pain, inflammation, and some diseases associated with oxidative stress in African traditional medicine. This study investigated the anti-inflammatory and analgesic activities, the acute toxicity and anti-oxidant properties of AML, characterised the phytochemical constituents, and quantified its total phenolic and flavonoid contents. Anti-inflammatory and analgesic activities of AML extract were evaluated using carrageenan-induced oedema assay in rats’ paw and acetic acid-induced writhing assays respectively. Anti-oxidant effect of the extract was assessed in vivo by measuring liver antioxidant enzymes and in vitro by using DPPH radical scavenging assay and the acute toxicity of the extract was investigated in vivo in mice. The phytochemicals were characterised using basic phytochemical screening and total phenolics and flavonoids were quantified using established methods. The AML extract exhibited significantly high anti-inflammatory activity and moderate analgesic activity compared to diclofenac sodium. The extract exhibited moderate DPPH scavenging activity, significantly increased Superoxide Dismutase (SOD) and Glutathione peroxidase (GPX) activities, and did not have any effect on lipid peroxidation. AML was found to contain high phenolic and low flavonoids. The LD50 of the extract was above 5000 mg/kg body weight. In conclusion, the AML extract possessed significant anti-inflammatory and moderate analgesic activities, which may be mediated through its strong antioxidant properties due to its phenolic contents. The LD50 value showed that the extract was safe in the short-term utilization. The extract may therefore serve as a source of anti-inflammatory, analgesic and antioxidant agents.
      PubDate: 2022-06-01
       
  • Evaluating the effect of cinnamon and rosuvastatin, on the formation of
           foam cells in macrophages co-cultured with platelets

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      Abstract: Atherosclerosis is a progressive inflammatory disease caused by the deposition of lipids in the arterial endothelial cells. Various medications, including rosuvastatin, are recommended to treat the atherosclerosis, in other hand, Cinnamon extract has been shown to treatment atherosclerosis by modulate macrophage activation. According to these properties, we evaluate the synergistic effect of cinnamon and rosuvastatin on the formation of foam cells in the macrophages-derived from U937 cells. To investigate the toxicity of rosuvastatin and cinnamon, MTT assay was employed. The formation of foam cells was evaluated by Oil red O staining. Flow cytometry was employed to determinate CD 163 marker. RQ-PCR was used to determine the expression level of the genes which involved in cholesterol metabolism in foam cells. Data were analyzed using t-student and ANOVA tests. Our finding indicated that, the foam cells formation significantly decreased in the presence of rosuvastatin and cinnamon extraction. Expression of the CD163 on foam cell surface was also increased during exposure to these two agents. The expression level of LXR and PPARγ genes in foam cells in accompany with platelet and ox-LDL was significantly increased (p < 0.01), but the expression of SRA was reduced. The expression of SRB1 and ACAT1 significantly increased (p < 0.05, p < 0.01) in PLT and ox-LDL groups. Both cinnamon and rosuvastatin could robustly induce M2 macrophages with anti-inflammatory properties and reduce foam cell formation, suggesting that the combination of two agents may treat the atherosclerosis.
      PubDate: 2022-06-01
       
  • Pharmacognostic characterization and development of quality control
           standards for Dictamnus albus: a comparative study of different parts

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      Abstract: Dictamnus albus L. (Rutaceae), commonly known as gas plant, has tremendous medicinal importance. Although the plant has been scientifically evaluated for its various biological activities but no work has not been carried out till date on pharmacognostic characterization of the plant. This study aims to investigate the comparative pharmacognostic and physicochemical standards for different parts of D. albus (leaves, stem, root, flower and fruits). The measures taken were macroscopy, organoleptic study, anatomy, powder microscopy, foreign matter analysis, ash values, loss on drying, swelling index, foaming index, pH values, fluorescence analysis and extractive yield. Macroscopic and organoleptic studies revealed that D. albus is a herbaceous perennial with thick and branched root; lanceolate, sessile and pubescent leaves; hollow and glabrous stem; terminal paniculate inflorescence and star shaped fruits and each part has a characteristic odor with a bitter taste. Anatomy of D. albus revealed some diagnostic characteristics- irregular shaped epidermal cells and unicellular trichomes in leaves; hexagonal pith cells containing secretory cells in stem and cortex containing oil globules in root. The powder analysis showed peculiar features as—wavy epidermal cells, different trichomes, prismatic crystals, oil globules and lignified spiral and pitted vessels in leaf; prismatic calcium oxalate sheath and lignified spiral and pitted vessels in stem; cork cells and sieve elements in root; lignified spiral vessels, stomata, trichomes and secretary glands in flowers; stone cells, secretary glands, glandular trichomes, lignified spiral and pitted vessels, prismatic crystals in fruit. Also, the analysis of pharmacognostic parameters of different parts resulted in a valuable data to establish standards for the plant.The present study for the first time provides a complete pharmacognostic profile of D. albus, thereby, acting as a platform for correct identification, authentication and development of quality control parameters of the species. Unlike taxonomic identification, pharmacognostic studies includes those parameters and standards that prove helpful in identifying adulteration in powdered form also. Data obtained may be used a standard for future studies.
      PubDate: 2022-06-01
       
  • Preliminary screening of phytochemicals and antimicrobial activity of
           Citrus pseudolimon

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      Abstract: Plants contain a wide range of phytochemical constituents and therefore, are used in the pharmaceutical industry either indirectly or directly. Citrus pseudolimon is an important medicinal plant of the family Rutaceae and, had not been previously explored for any beneficial effect. The main objective of the study was to perform the phytochemical quantitative analysis and demonstrate the antimicrobial activity of Citrus pseudolimon peel and juice. The results thus, obtained with respect to the quantitative phytochemical analysis was recorded with higher total carbohydrates, proteins, phenolics, flavonoids, and tannin contents in the peel of Citrus pseudolimon when compared to its juice content. The quantitative phytochemical screening demonstrates that flavonoid content was higher in peel (5.47 mg/100 mg) than in juice (2.67 mg/100 ml), followed by the phenolic content which was little higher in peel (5.58 mg/100 mg) compared to that reported (0.34 mg/100 ml) in juice content respectively. Similarly, the tannin content was found to be higher in peel (35.70 mg/100 mg) than in juice (14.15 mg/100 ml). Furthermore, the tannin content in Citrus pseudolimon was found higher than phenolic and flavonoid content. However, in antimicrobial analysis, juice revealed stronger activity against gram-negative bacteria Escherichia coli zone (24 mm) than gram-positive bacteria Staphylococcus aureus (18 mm) while no activity was shown by peel against both these bacterial strains. It can be concluded that the peels revealed high phytochemical content, while juice fraction was recorded with strong antibacterial activity.
      PubDate: 2022-06-01
       
  • Effects of traditional Chinese medicine Chaihu-Shugan-San aqueous extract
           on high-fat diet-induced liver steatosis in rats via intestinal microbiota
           metabolite SCFAs and its receptor Gpr43/109a

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      Abstract: Non-alcoholic fatty liver disease (NAFLD) is one of the most common chronic liver diseases in adults around China and the world. The study explores protective effect of traditional Chinese medicine Chaihu-Shugan-San decoction on high-fat diet-induced liver steatosis in rats via intestinal microbiota metabolite short-chain fatty acids (SCFAs) and its receptor Gpr43/109a. Fifteen male Sprague–Dawley rats were randomly divided into three groups of five rats each: the control group (standard diet), High-fat diet (HFD)-induced NAFLD group (83% standard diet + 10% lard oil + 5% sucrose + 1.5% cholesterol + 0.5% cholate), and Chaihu-Shugan-San (CSS)-treated group (HFD + 9.6 g/kg body weight gastric administration of CSS decoction every day). Body composition, hepatic fat, intestinal mucosal permeability and SCFAs, Gpr43 and Gpr109a expression in colonic tissues were assessed. Compared with NAFLD group, CSS decoction significantly reduced body weight, liver weight, hepatic triglyceride and total cholesterol (P < 0.05), and increased colonic SCFAs and occludin expression. The levels of Gpr43 and Gpr109a also changed significantly (P < 0.05). Protective effect of CSS decoction in HFD-induced NAFLD rats might improve intestinal mucosal permeability and intestinal microbiota metabolite SCFAs through Gpr43 and Gpr109a pathways in colonic tissues.
      PubDate: 2022-06-01
       
  • Hepatoprotective potential of the n-butanol extract of Moricandia arvensis
           from Algeria against doxorubicin induced toxicity in Wistar albino rats

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      Abstract: Doxorubicin (DOX) is a potent anticancer drug; its use has been limited by its hepatotoxicity, which is due to free radicals generation. This work aims to investigate whether the n-butanol soluble part of the 70% methanol extract of the aerial parts of Moricandia arvensis, alleviates doxorubicin-induced hepatotoxicity. According to the literature data, Moricandia arvensis (Brassicaceae) is renowned for its richness in flavonoid and phenolic acid glycosides. In this work, we have rightly assessed the total phenolic and flavonoid contents of the studied extract (n-butanol extract). The results obtained (TPC: 86.25 ± 0.00 µg GAE/mg; TFC: 22.54 ± 0.01 µg QE/mg) encouraged us to continue our investigations. Wistar albino rats were orally administered with n-butanol extract of M. arvensis (50 mg/kg and 100 mg/kg body weight) or vitamin E as a standard antioxidant (100 mg/kg) for 10 days; and DOX (15 mg/kg on the 8th day that was intraperitoneally injected. At the end of the experiment, blood and liver samples were analyzed for biomarker levels and histopathological changes. Liver homogenates were used to determine oxidative stress parameters such as malondialdehyde (MDA), glutathione peroxidase (GPX) and glutathione (GSH) activity. DOX-administered rats significantly increased different levels of the serum biochemical parameters, increased TBARS level, decreased GPx activity and GSH level in the liver. In addition, M. arvensis (50 mg/kg and100 mg/kg) n-butanol extract treatments significantly decreased the level of TBARS, increased GSH level and GPx activity compared to the DOX-treated rats (p < 0.01). The histological study revealed the hepatoprotective effects of the tested extract on DOX-induced toxicity. This was demonstrated by the preservation of hepatic architecture as well as a reduction in structural and functional changes in the liver. The obtained results indicate a protective action of n-butanol extract of M. arvensis that could be the result of the inhibition of reactive oxygen species (ROS) generation. This may be the result of the presence of phenolic compounds in M. arvensis plant.
      PubDate: 2022-05-16
       
  • A search for potential anti-HIV phytoconstituents from the natural product
           repository

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      Abstract: A chronic, life threatening and immuno-suppressing malady caused by Human immunodeficiency virus (HIV) is formally known as Acquired Immune Deficiency Syndrome (AIDS). Currently, combinations of several anti-retroviral drugs are being used for the management of HIV infection. These drugs possess certain limitations and hence researchers across the globe are striving to explore treatment methodologies based on medicinal plants of natural origin in order to develop safe and effective treatment. In this review, various medicinal plants are categorized on the basis of target of action namely Reverse transcriptase enzyme, Protease enzyme, Integrase enzyme, cell fusion, CC chemokine receptor 5 (CCR5) CXC chemokine receptor 4 (CXCR4). Medicinal plants exhibiting multi-targeted activities against various targets of HIV are also reviewed. Detail description of medicinal plants with their habitat, common names, category of systems of medicines, phytoconstituents and their biological activities in terms of relative % inhibition or IC50 or EC50 are provided in this review. Anti-HIV benefits of these plants are observed due to phytoconstituents like terpenoids, tannins, alkaloids, polyphenols, coumarins, flavonoids, etc. In order to gain the structural knowledge for future developments of anti-HIV leads, ligand based pharmacophore was generated using phytoconstituents mentioned in this review. Structural modifications of these phytoconstituents on hydrophobic, donor and acceptor regions are beneficial for the potent anti-HIV activity. In conclusion, this study may prove to be a stepping stone towards the use of herbal medicinal plants for the management of HIV/AIDS and may aspire researchers to look for new treatment options from the natural sources. Graphical abstract
      PubDate: 2022-05-14
       
 
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