JournalTOCs

Asian Journal of Research in Medical and Pharmaceutical Sciences
Number of Followers: 0

This is an Open Access Journal

Open Access journal
ISSN (Online) 2457-0745
Published by SCIENCEDOMAIN international

[65 journals]

Modulation of Obesity in Sub-Saharan Africa Using Coenzyme Q10
- Authors: Doris Nnenna Ajibo, Ifeoma Cynthia Ekenna
  Pages: 1 - 12
  Abstract: Obesity is a metabolic disease caused by a large buildup of fat in the body and a deficit in energy consumption compared to energy disposal. It has been related to a shorter life expectancy, has been connected to various cancer types, and has been linked to secondary metabolic illnesses such as diabetes, atherosclerosis, and hypertension. Due to an increase in white adipose tissue deposition, oxidative stress can lead to obesity, and obesity can lead to increased oxidative stress in the body. Coenzyme Q10 (Ubiquinone) is an endogenous anti-oxidant with anti-oxidant properties that aids to reduce oxidative stress. It boosts the anti-oxidant activity of superoxide dismutase and glutathione peroxidase, reduces lipid peroxidation, neutralises free radicals, and promotes vitamin E and C regeneration in the body. It can be found in the form of ubiquinol or ubiquinone. CoQ10 may be found in both diet and supplements. It can be made as a syrup, tablet, soft gel capsule, hard shell capsule, or oral powder as a supplement. It is classified as a biopharmaceutical class II compound with low solubility but good permeability. When CoQ10 supplement is taken with a fatty meal, its bioavailability is increased. CoQ10 slows the evolution of obesity-related atherosclerosis and helps to mitigate the harmful bodily environment caused by obesity.
  PubDate: 2022-03-31
  DOI: 10.9734/ajrimps/2022/v11i230182
Oral Spray – A Review on Promising Drug Delivery System for Oral
Cavity
- Authors: Chirag Parmar, Nidhi Joshi, Prachi Modi, Priyank Bhavsar, Nishtha Desai, Adil Patel
  Pages: 13 - 21
  Abstract: Aim: This review aims to compile information related to marketed oral spray preparation along with their formulation and clinical application. Objective: The main objective of this overview is to study the marketed oral spray dosage form for treatment of different diseases and learn about its advantages over the other oral dosage forms e.g. tablet, capsule, patches etc. Description: Oral spray with Mucoadhesive polymers forms small droplets that quickly adheres to the mucosal surface and let the drug permeate into the blood circulation easily. The oral mucosa has shown promising results for the systemic absorption of many drugs owing to the highly permeable nature of the mucosal membrane. Oral sprays are very fast, the most effective and easy way to get daily dose vitamins, minerals, and other nutrients ingredients. Due to this advantage oral sprays have emerged as an effective alternative for bypassing extensive first pass effect. Conclusion: It has been a very well known fact that the oral route of administration is the most popular route of drug administration. However the drwabacks like extensive first pass metabolism and drug degradation in stomach makes this route not suitable for all drugs and thus an alternative oral drug delivery systems are necessary to explaoint benefits of oral route. Many researchers are working to develop oral spray formulations for drugs which need quick permeation followed by quick onset of action and also provide an effective alternative of conventional oral drug delivery systems.
  PubDate: 2022-04-22
  DOI: 10.9734/ajrimps/2022/v11i230183
An Unusual Cause of Upper Airway Obstruction: A Case Report
- Authors: Mohammed Jamaan Alzahrani
  Pages: 22 - 25
  Abstract: Background: Dumb cane, or Dieffenbachia, is a tropical decorative house plant belonging to the Araceae family and the Arum class, and its colored leaves are appealing to children. Objective: The rationale of this report is to notify health workers and the community about the danger of such plant poisoning and increase awareness about its toxic effect on humans. Case Report: A 14-month-old girl presented to the emergency department complaining of a history of cough, difficult breathing, excessive crying, lip swelling, and drooling of saliva after ingestion of Dieffenbachia. Upon arrival, she had mild respiratory distress associated with stridor. Her examination showed lip swelling, tongue sore, and redness with scattered blisters. These symptoms resolved after a few hours of receiving respiratory support with oxygen therapy, intravenous fluids, intravenous Dexamethasone, racemic epinephrine, oral antihistamines, and normal saline rinses. Conclusion: The community lacks awareness about home plant poisoning. The significance of reporting such cases highlights the need for parents and community awareness to prevent the toxicity of more people, especially youngsters.
  PubDate: 2022-04-25
Investigation of Pharmaceutical Care Practice in Two Tertiary Health Care
Facilities in Central Monrovia, Liberia
- Authors: CHEA; Sampson K. P., Woode, Eric
  Pages: 26 - 35
  Abstract: Aims: to identify elements of pharmaceutical care and to what extend it is practiced in these hospitals and to identify any drug-related therapeutic problems and determine the perceived importance of pharmaceutical care. Study Design: A prospective, cross-sectional descriptive survey was carried out among hospital pharmacists and some selected physicians and physician assistants working at two major tertiary healthcare facilities in Liberia. Place and Duration of Study: John F. Kennedy Memorial Hospital, and Eternal Love Winning Africa Hospital, between August, 2021 and October, 2021. Methodology: Pretested structured questionnaires covering demographics and the key elements of pharmaceutical care documentation was administered randomly to 43 health professionals in these hospitals and collected for compilations and analysis. Results: Twenty percent (20.9%) confirmed the documentation of pharmaceutical care elements in both facilities, and 18.6% confirmed the documentations of interventions. Methods used in documentation are paper (13.9%), manual (72.1%) and computers (6.9%) respectively. Unnecessary drug therapy/unwanted indication, adverse drug reactions, drug interactions, need for additional drugs, dosage too high, dosage too low, wrong drugs, and inappropriate compliance are the drug therapy problems that exist at both facilities. The overall percentage of all the drug therapy problems is twenty-five percent (25.6%), of which most are highlighted at John F. Kennedy Memorial Hospital, though these problems exist at both hospitals. There is an increase in drug therapy problems and a decrease in standard documentation format and method used to document pharmaceutical care at both hospitals. Thirty-nine percent (39.5 %) of the respondents recognized the importance of the documentation of pharmaceutical care (PC). Conclusion: The study findings revealed that there is semblance of elements of pharmaceutical care activities at the both hospitals, but it is limited. Inadequate documentations of PC interventions coupled with primitive methods of recording PC data are highlighted by respondents. The practice of pharmaceutical care in the Liberia’s healthcare system can greatly improve the quality of pharmaceutical services and enhance the quality of life and therapeutic outcomes to patients/clients.
  PubDate: 2022-04-26