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European Research Journal
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This is an Open Access Journal

Open Access journal
ISSN (Online) 2149-3189
Published by DergiPark

[185 journals]

Interleukin-23 receptor gene polymorphisms in osteoporosis
- Authors: Firdevs ULUTAŞ; Ozan ÇETİN, Veli ÇOBANKARA
  Abstract: Objectives: Osteoporosis (OP) is a usual disease with a possible genetic predisposition. IL-23 plays a role in physiological bone remodeling and regulates the activity of cells of the bone either directly or indirectly on bone-resorbing osteoclasts as well as on bone-forming osteoblasts. Recent animal and human trials have revealed the main pro-osteoclastogenic activities for the IL-23 pathway. We examined nine single nucleotide polymorphisms (SNPs) in the interleukin-23 receptor (IL-23R) in 100 OP patients and gender- and age-matched 96 healthy volunteers. The most analyzed SNPs in the recent rheumatology literature were selected.Methods: In addition to gene polymorphisms several laboratory parameters (osteocalcin, parathormone, vitamine D) were investigated. Independent Samples t-test and Mann-Whitney-U test were used to compare several demographic and clinical parameters between the groups. P-value < 0.05 was accepted to be statistically significant.Results: Having the heterozygous GA genotype of IL-23R rs1004819 and the heterozygous CT genotype of Il-23R rs7530511 significantly increase the risk of developing OP (adjusted OR: 3.51, p = 0.031 and OR: 2.41, p = 0.027, respectively). The wild homozygous GG genotype of Il-23R rs11209032 had higher osteocalcin levels compared with the mutant homozygous AA genotype (18.75 ± 9.76, p = 0.009).Conclusions: Our findings suggest that several IL-23R gene polymorphisms are seen more often in osteoporosis patients than in healthy volunteers. In addition, some SNPs were related to higher serum osteocalcin levels.
  PubDate: Sat, 04 Nov 2023 00:00:00 +030
Investigation of the impact of radiotherapy on the shoulder joint by
ultrasonography in breast cancer patients
- Authors: Serdar KARATAŞ; Banu ALICIOĞLU
  Abstract: Objectives: This study aimed to investigate the impact of radiotherapy (RT) on the supraspinatus, long head of the biceps and subscapularis tendons, and shoulder subcutenous fat tissue. Methods: Patients diagnosed with breast cancer who received RT to the anterior chest wall and axillary-supraclavicular region after breast-conserving surgery or mastectomy in our hospital. Overall, 56 (36 RT, 20 control group) patients were enrolled in this study. Pre-RT, post-RT 6-week, 3-month, and 6-month ultrasonographic and clinical assessments were performed. Results: The mean interval between surgery and RT was 5.6 (range: 2-8) months. Ten (27.7%) patients developed ultrasonographic abnormalities during the post-RT period. However, only 2 of these patients had shoulder pain and restricted range of motion in the shoulder. The thickness of the supraspinatus, biceps and subscapularis tendons were similar between the dominant and non-dominant sides of the control and RT group patients (5.7 mm vs. 5.1 mm, 2.87 mm vs. 2.89 mm, and 4.13 mm vs. 3.97 mm; respectively, p > 0.05). Thirteen patients were given RT on the ipsilateral side, and 23 received RT on the contralateral side. The pre-RT supraspinatus tendon thickness was significantly higher in the ipsilateral group than in the contralateral group (p = 0.026). However, there was no significant difference in the post-RT period (p = 0.408). Conclusions: In breast cancer patients undergoing adjuvant RT, RT may cause temporary edema in shoulder tendons. In addition, shoulder pain and restricted range of motion of the shoulder joint can be present in these patients.
  PubDate: Sat, 04 Nov 2023 00:00:00 +030
''Should the child be raised as male or female''' The evaluation and
management of different causes of ambiguous genital appearance in children
- Authors: Salma AL KHANJARİ; Malak Saleem AL BALUSHİ, Ravi Prakash KANOJİA, Mohammed Jaffer AL SAJWANİ
  Abstract: Diagnosing, managing and assigning gender for different causes of ambiguous genitalia in children can be challenging. This article will discuss about the types, diagnosis and treatment of disorders of sex development including congenital adrenal hyperplasia, 46 XY mixed gonadal dysgenesis and 46XY ovotesticular disorder of sex development. This article reports about 3 cases of disorders of sex development. The first case is about a three-year-old girl who was diagnosed with congenital adrenal hyperplasia, genital examination revealed clitoromegaly and a single urogenital sinus; she was managed medically and surgically. The second case is about a one-month-old child with 46XY karyotype, genital examination revealed penoscrotal hypospadias with right palpable and left impalpable gonads. Patient underwent diagnostic laparoscopy in which both female and male internal organs were found; based on these results a diagnosis of 46XY ovotesticular disorder of sex development was made. The third case is about a 3-month-old child with 46XY karyotype, genital examination revealed hypospadias with bilateral impalpable gonads. Diagnostic laparoscopy showed a uterus with a bilateral ovary-looking gonad; histopathology of the bilateral ovary-looking gonads was consistent with testicular tissue. Based on the above, a diagnosis of 46XY mixed gonadal dysgenesis was made. Disorders of sex development are classified into three main categories based on the karyotype, XX, XY and sex chromosome other than XX and XY. Laboratory investigations, karyotype, genetic analysis, imaging, surgery and tissue biopsy, all aid in diagnosing, deciding gender identity and managing different types of disorders of sex development.
  PubDate: Sat, 04 Nov 2023 00:00:00 +030
A case developing bilateral bullae due to COVID-19 infection and operated
for recurrent pneumothorax
- Authors: Elçin ERSÖZ KÖSE; Kaan Ayberk BOYACIOĞLU, Sümeyye ALPARSLAN BEKİR, Cansel ATİNKAYA BAYTEMİR, İrfan YALÇINKAYA
  Abstract: In December 2019, a novel coronavirus (COVID-19) pneumonia emerged in Wuhan, China and has rapidly spread to multiple countries worldwide. Pulmonary parenchymal opacities are often observed during chest radiography. Pneumothorax was reported in 1% of patients in studies. In this paper, we aimed to present a patient with a history of long-term hospitalization in intensive care unit due to COVID-19 pneumonia who was operated for right recurrent pneumothorax secondary to COVID-19 after discharge.
  PubDate: Sat, 04 Nov 2023 00:00:00 +030
Case report of rare tissue injury and left arm dislocation after incorrect
blood pressure measurement during clinical practice
- Authors: Özen Esra KARAMAN; Yüksel Duygu ALTIPARMAK
  Abstract: In midwifery education based on theoretical and practical foundations, students encounter midwifery profession education which based on for the first time in the Basic Clinical Skills in Midwifery Course. The aim of the Basic Clinical Skills in Midwifery Course is to help students understand the basic philosophy of midwifery and the role of the midwife in the health system, and to provide the student with knowledge, skills and attitudes about the basic concepts, principles and methods in midwifery care. In the Basic Clinical Skills in Midwifery Course, students are offered learning methods that will enable them to develop behaviors in the cognitive, affective and psychomotor domains. In this context, the course is carried out in skill development laboratories and clinical environments, after the lecturer in the classroom explains the basic concepts, the health system and midwifery, the protection and development of health, the fulfillment of physiological care needs, and the demonstration of the skills related to the psychomotor domain. Clinical practices are an indispensable element of midwifery education. The Midwifery Basic Clinical Skills Course has a very important place in clinical skills training, as students experience the hospital environment for the first time in their education life and experience midwifery practices for the first time on real patients. The aim here is to discuss a case that can be experienced after the correct application of vital sign measurement techniques and erroneous measurement.
  PubDate: Sat, 04 Nov 2023 00:00:00 +030
Integration of digitalization into occupational health and safety and its
applicability: a literature review
- Authors: Cengiz AKYILDIZ
  Abstract: The primary aim of this study is to review the transformation of occupational health and safety (OHS) practices in the digital age, particularly in light of the onset of Industry 4.0. The study seeks to understand the emergence of OHS 4.0 methodologies and their implications for enhancing performance, reducing risks, and addressing workplace challenges. The overarching objective is to explore the innovations in the OHS domain influenced by digitalization and ascertain the benefits and challenges of integrating digital methodologies into OHS practices. A comprehensive literature review was conducted, scanning multiple sources to gather insights on the innovations brought about by digitalization in the OHS domain. The study further analyzed contemporary research and application areas of new technologies in occupational health and safety. Findings from the study confirm that the integration of digital technologies into the OHS domain can lead to a significant reduction in workplace accidents. However, as workplaces embrace digital processes, new types of risks emerge for employees. In adapting to digitalization, there are recognized challenges in areas like privacy, security, clarity, and responsibility. Digitalization has redefined the landscape of OHS, ushering in an era of OHS 4.0. While the digital methodologies offer significant advantages in reducing workplace accidents and enhancing performance, they also present new risks and challenges. As the workplace undergoes rapid changes due to technological advancements, there's a pressing need to develop OHS approaches that align with the demands of the modern age, ensuring that health and safety remain paramount amidst uncertainties in applicability.
  PubDate: Sat, 04 Nov 2023 00:00:00 +030
Efficacy and safety outcomes of single-agent ibrutinib therapy in chronic
lymphocytic leukemia and relapsed/refractory mantle-cell lymphoma
- Authors: İbrahim Ethem PINAR; Vildan OZKOCAMAN
  Abstract: Objectives: We aimed to evaluate patients using ibrutinib for the treatment of chronic lymphocytic leukemia (CLL) and relapsed/refractory mantle-cell lymphoma (MCL), focusing on high-risk subgroups, predictors of efficacy, response levels, and safety profile.Methods: This retrospective cohort study included adult patients diagnosed with CLL and relapsed/refractory MCL who were started on ibrutinib as a single-agent between May 2015 and December 2021 in Bursa Uludag University, Department of Hematology.Results: Of the 45 patients (23 CLL, 22 MCL) started on ibrutinib, the median age was 65 (range: 48-86) years, and 66.7% were male. Del(17p) was present in 47.8% of CLL patients; there was no remarkable difference between del(17p) status and the rates of achieving CR. The median follow-up with ibrutinib treatment in CLL patients was 13.3 (range: 0.3-77.8) months. In univariate analysis, progression-free survival (PFS) and overall survival (OS) were associated with the advanced Eastern Cooperative Oncology Group (ECOG) score (p = 0.003 and p = 0.004, respectively), and > 2 lines treatment regimens before ibrutinib (p = 0.016 and p = 0.050, respectively). In multivariate analysis, the ECOG performance status remained significant for OS. The median use of ibrutinib for MCL patients was 6 (range: 1-48) months, and the proportion of patients who achieved CR was 27.3%. In the univariate analysis of MCL patients, the ECOG performance status for PFS and OS was statistically significant (p = 0.045 and p = 0.016, respectively). Patients' most common non-hematological adverse events were pneumonia and urinary tract infection.Conclusions: Our investigation of patient outcomes treated outside clinical trials confirms ibrutinib's sufficient efficacy and safety profile in CLL and relapsed/refractory MCL.
  PubDate: Sat, 04 Nov 2023 00:00:00 +030
Comparison of manual lymphatic drainage massage and negative pressure
massage therapy efficacy in lymphedema patients: a randomized controlled
study
- Authors: Sedef ERSOY; Nur KESİKTAŞ, Büşra ŞİRİN, Nazlı Derya BUĞDAYCI, Halime KİBAR, Nurdan PAKER
  Abstract: Objectives: Lower extremity lymphedema due to secondary causes is a lifelong complication that can be encountered. Its treatment is essential, because it has significant impact on quality of life and daily living activities related to lower extremity involvement. This research aims to compare the effects of Manual Lymphatic Drainage Massage (MLD) and Negative Pressure Massage Therapy (NPMT) treatments in order to provide maximum benefit to patients. Methods: This prospective, randomized study included 30 patients with lower extremity lymphedema due to secondary causes. Patients, randomized using computer software, were divided into two groups. The first group (n =15) received 45 minutes, 15 sessions of MLD, while the second group (n =15) received 45 minutes of 15 sessions of NPMT using the LymphaTouch device. Compression bandaging was applied to both groups and self-drainage training was given to all patients. The circumference of the extremity at 6 reference points were measured and their pain and discomfort assessed by the Visual Analogue Scale (VAS) were recorded before and after treatment. Changes within the groups and between the groups were compared using the SPSS statistical program. Results: Statistically significant improvement was observed in all parameters in both treatment groups. The decrease in VAS pain and VAS discomfort scores (p < 0.05 and p < 0.01; respectively), circumference measurement of the extremity (p < 0.01) was statistically greater in the NPMT group compared to the MLD group. Conclusions: In conclusion, NPMT appears to be a beneficial non-invasive treatment method for reducing extremity volumes and decreasing subjective pain and discomfort in lymphedema patients.
  PubDate: Sat, 04 Nov 2023 00:00:00 +030
Comparative retrospective analysis of patients with idiopathic normal
pressure hydrocephalus and aqueductal web-related aqueductal stenosis.
- Authors: Alper TÜRKKAN; Pınar ESER OCAK, Oğuz ALTUNYUVA, Buket SÖNMEZ, Rifat ÖZPAR, Ahmet BEKAR
  Abstract: Objectives: Aquaductal web (AW) is a special form of aqueductal stenosis with similar clinical presentation with idiopathic normal pressure hydrocephalus (iNPH). iNPH is indeed a communicating hydrocephalus syndrome whereas AW is a noncommunicating subtype. Here, we aimed to investigate the similarities and differences between these two different chronic hydrocephalus syndromes in terms of clinical signs and symptoms, response to shunt treatment and postoperative complications.Methods: Forty-one patients who underwent shunt operation with the diagnosis of iNPH or AW at our clinic between January 2010-May 2019 were retrospectively analyzed. Patients were evaluated by age, gender, clinical sign and symptoms, comorbidities, intraoperative and postoperative complications, and early and late postoperative outpatient follow-up findings.Results: Twenty-six patients were classified as iNPH group and 15 patients as AW group. Patients in the AW group were significantly younger (45.5 ± 15.6 years vs. 60.3 ± 15.4 years) than the iNPH group (p = 0.006). There was no statistical difference between the groups in terms of subdural effusion formation, need for shunt revision (p = 1.000). Chronic hydrocephalus symptoms regressed in 23 (88.5%) patients in the NPH group, and at least one of them improved. symptoms. This rate was 66.7% (n = 10) in the AW group. Both groups showed similar clinical improvement with VPS (p = 0.1169). Conclusions: The placement of ventriculoperitoenal shunt is widely used in the treatment of iNPH. As iNPH and AW has clinical similarities despite the discrepancies between underlying pathophysiological mechanisms and both clinical entities respond similarly to shunt treatment we advocate VPS surgery in the management of AW as well.
  PubDate: Sat, 04 Nov 2023 00:00:00 +030
Evaluation of the clinical value of sodium examination in spot urine in
patients presenting with acute heart failure while using SGLT2i –
‘‘SPOT HF STUDY’’
- Authors: Onur ASLAN; Emre Emrah DEMİRCİ
  Abstract: Objectives: Sodium measurement in spot urine provides important information about the adequacy of the initial dose in acute heart failure (AHF) patients using intravenous diuretic (IV) and makes a guiding contribution to the titration decision. It is not clear whether spot urine sodium measurement has the same clinical value as the effect of sodium-glucose cotransporter 2 inhibitor (SGLT2i) drugs on urinary electrolytes. Our aim in our study is to investigate the clinical value of sodium examination in spot urine in AHF patients while using SGLT2i. Methods: Our study was conducted retrospectively and single-centered. AHF patients, administered IV diuretics were included in the study. Patients who were using and were not using SGLT2i were examined in two groups. The 2nd and 6th-hour sodium values in spot urine were measured. Results: Patients using SGLT2i (n = 46) and not using it (n = 54) were included. The mean age was 69.91 ± 11.84 years and 47% were female. The standard deviation value for the sodium in spot urine in patients using SGLT2i was clearly high and its distribution was significantly higher. A weak correlation was found between the sodium value in spot urine and the 24-hour urine volume in this group. Hospitalization history within 1 month after discharge was found to be 39% in the group using SGLT2i, and 51% in the group that did not use it, and this difference was statistically significant.Conclusions: The measurement of sodium in spot urine does not seem to have the same clinical value in HF patients using SGLT2i. Its correlation with urine volume is also decreasing in this group.
  PubDate: Sat, 04 Nov 2023 00:00:00 +030
Unusual metastases of breast cancer: a single-center retrospective study
- Authors: Pınar ÖZDEMİR AKDUR; Nazan ÇİLEDAĞ
  Abstract: Objectives: While clinical and radiological awareness of the usual, frequent metastatic sites of breast cancer is high, unexpected 'atypical' localisations may be more easily overlooked in the cancer management process. The aim of this article is to contribute to this awareness in order to facilitate and improve the diagnosis and follow-up of breast cancer.Methods: In this study, we retrospectively evaluated breast cancer patients who were diagnosed and followed up between 2017 and 2022 in our hospital, which is an important oncology center. Results: Of the 852 patients included in this study, 79 had an unusual metastasis localization. The most common unusual metastasis sites were mediastinal lymph nodes and brain. These sites were followed by atypical bone involvement, mesenteric lymph nodes, cervical lymph nodes, hilar lymph nodes and surrenal metastases. The most rare metastases were more common in the uterus and ovary, followed by pancreas, parotid gland, spleen, colon, pericardium-atrium, orbital soft tissues and lacrimal gland. . The unusual site of metastasis was mediastinal lymph nodes in 17.7% (n = 14), brain in 17.7% (n = 14), atypical bone sites in 12.6% (n = 10), mesenteric lymph nodes in 11.3% (n = 9), cervical lymph nodes in 11.3% (n = 9), hilar lymph nodes in 5% (n = 4) and surrenal in 6.3% (n = 5). Conclusions: Sharing knowledge and experience about unusual metastases of breast cancer will contribute to the diagnosis and treatment of metastatic diseases by increasing the awareness of this issue. For this, multicentre studies should be conducted to combine these experiences.
  PubDate: Sat, 04 Nov 2023 00:00:00 +030
Next-generation sequencing panel test results in pediatric patients with
- Authors: Ali TOPAK
  Abstract: Objective: The aim of this study is to reveal the diagnostic yield of the progressive familial intrahepatic cholestasis (PFIC) gene panel that we have used in the diagnosis of this patient group, which accounts for approximately 10% of cholestatic liver disease, and to report the clinical findings of our patients with the detected variants. Methods: In this study, we retrospectively evaluated the results of molecular genetic analysis of pediatric patients whose PFIC gene panel contained the ATP8B1, ABCB11, and ABCB4 genes.Results: In 10 patients, 12 different variants were detected that could explain the PFIC clinical picture. Three of these variants were considered novel variants.Conclusion: Our study demonstrates the usefulness of the NGS panel in diagnosing pediatric patients with PFIC findings. This diagnostic method also contributed to the variant spectrum of PFIC-related genes.
  PubDate: Sat, 04 Nov 2023 00:00:00 +030
Increasing self-protection skills of children staying in women's shelters
with body safety training: a child sexual abuse prevention study
- Authors: Gülseren ÇITAK-TUNÇ; Dilek ESER, Fatma KILINÇ
  Abstract: Objectives: Child sexual abuse is a risk for children living in a happy family environment, as well as for children under state protection who have problems in achieving family unity. Methods: The study was conducted with 17 children between 3-7 years of age staying at women’s shelters with their mothers and aimed to improve their sexual abuse recognition and self-protection skills. 7 children identified as experimental group were provided with the Body Safety Training program and the effect of the training was evaluated with the “What If” Situation Test. The test results in the experimental group were compared with 10 children in the control group and the test was repeated three weeks later in order to determine the persistance of the training. Results: The data obtained were evaluated by non-parametric analysis and Kruskal Wallis, Wilcoxon-signed Rank Test were used in addition to Mann Whitney U tests to determine the difference between the groups. As a result of the research, “What If” Situation Test sub-dimension mean scores showed an increase in favor of the post-test in the experimental group, but no significant increase was observed in the control group. Conclusions: This difference observed in the experimental group shows that the Body Safety Training program is an effective program to increase self-protection skills for preventing sexual abuse in children.
  PubDate: Sat, 04 Nov 2023 00:00:00 +030
The effect of hypertension in pregnancy and central nervous system
anomalies on fetal brain development
- Authors: Mehmet ALBAYRAK; M. Faruk KÖSE, Banu ANLAR
  Abstract: Objectives: The aim of this study was to investigate whether maternal hypertension affects fetal brain maturation, and to examine whether treatment with magnesium sulfate has a protective effect on the fetal brain.Methods: A total of 26 fetuses, including 11 dead fetuses of pregnant women who were found to have hypertension and whose pregnancy was terminated due to this reason, and 15 fetuses who did not have this risk factor but died for various reasons as the control group, were included in the study. Brain tissue samples were evaluated for the presence of morphological and histopathological changes, as well as apoptotic cells. The morphologies of the samples were examined in sections stained with hematoxylin-eosin (H&E), and apoptosis was examined with light microscopy by the terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) method. Results: In the control group, it was observed that the brain tissue had a morphological structure compatible with the development weeks. In the hypertension group, there were no bleeding foci and brain tissues mostly preserved morphological features similar to control patients. While edema was detected in 45.4% of the infants in the hypertension group, no edema was observed in 54.6%. In the hypertension group, Grade 1 necrosis was observed in 63.6% of the samples, Grade 2 necrosis was observed in 9.1%, and no necrosis was observed in 27.3% of the samples.Conclusions: Based on the findings of this study, it can be concluded that maternal hypertension increases neurological maturation by causing vasodilation in the fetal brain, increasing blood flow, and decreasing cell death.
  PubDate: Sat, 04 Nov 2023 00:00:00 +030
Evaluation of pediatric patients installed due to acute gastroenteritis
- Authors: Özhan ORHAN; Mehmet BULUT
  Abstract: Objectives: Acute gastroenteritis is one of the most prevalent causes of death and morbidity in children and a significant health issue in Turkey, as well as developed and developing nations. The purpose of this study is to analyze retrospectively the patients with acute gastroenteritis who sought treatment at the Kızıltepe State Hospital in Mardin.Methods: This study was designed as a single-center retrospective study in which demographic variables were evaluated by taking fresh stool samples from the patients who applied to the Mardin Province Kızıltepe State Hospital between 01/11/2020 and 31/10/2021 with the complaint of diarrhea. The information of rotavirus, enteric adenovirus and amoeba viruses in stool samples was investigated by qualitative immunochromatographic test. The researcher assessed the research data utilizing the hospital's file archive materials and three factors set by the researcher. The researcher extracted the information about these factors from the patient files and stored it in a Microsoft Office Excel file.Results: According to the gender variable of the research participants, Amoeba positive rates were considerably higher in males than in girls (35.8% versus 22.6%, p = 0.046, respectively). According to the age groups variable, rotavirus antigen positive was statistically significantly greater in the 5-24 month age group compared to other age groups (p = 0.034). Similarly, Amoeba positive was statistically substantially higher in the 5-24 month age group compared to other age groups (p = 0.001). There was no significant variation between age groups in the distribution of adenovirus. According to the seasonal variable, rotavirus antigen positivity was most prevalent in the spring, and the difference between the spring and other seasons was statistically significant (p = 0.001), whereas amoeba positivity was most prevalent in the summer, with no statistically significant difference between the seasons (p = 0.003). The frequency of undiscovered variables was greater during the spring-summer months, and a statistically significant difference (p = 0.041) was identified between the groups. The seasonal variation in the prevalence of Adenovirus antigen positive was not statistically significant (p = 0.394). Conclusions: As a result, in poor and underdeveloped nations, it is among the top five causes of death in children under the age of five, in relation to acute gastroenteritis. Furthermore, the majority of these deaths may be minimized by preventative and prevention strategies. It is the responsibility of governments, health professionals, and families to foster a safe and healthy environment for all infants and children during their infancy and development. Community-based health strategies should be undertaken to lower the morbidity and death rates of millions of people worldwide who are exposed to harmful environmental conditions and malnutrition.
  PubDate: Sat, 04 Nov 2023 00:00:00 +030
Proprioception analysis of patients with anterior cruciate ligament
reconstruction
- Authors: Nazım ERKURT; Mustafa YERLİ, Ali YÜCE, Tahsin Olgun BAYRAKTAR, Sevgi ATAR, Kaya TURAN, Haluk ÇABUK
  Abstract: Objectives: This study evaluates the effect of tibial stump mechanoreceptor preservation on proprioception, muscle strength, recovery and functional outcomes after arthroscopic anterior cruciate ligament surgery (ACLS).Methods: Patients undergoing ACLS between January-July 2019 were evaluated by a single surgeon. The HUMAC NORM 2 device measured patients' proprioceptive sensation and muscle strength before and after surgery; KOOS and Oxford scales were used to score patients’ functional results. The patients were divided into two groups: those who underwent stump-preserving surgery (SP group) and those who underwent conventional surgery (C group).Results: Our study evaluated 27 patients, 11 in the SP and 16 in the C groups. The two groups had no statistical difference in muscle strength, proprioception, and functional scores in the first and third postoperative months. In the sixth-month evaluation, significantly better functional scores were found in the C group. Further, the athletic function was better in patients with good proprioception recovery, regardless of the group comparison.Conclusions: Preserving the stump and mechanoreceptors on the tibial face was not determined to provide additional benefit to the patients in the first six months after surgery. Returning to sports was faster and functional scores were better in patients with good proprioception recovery.
  PubDate: Sat, 04 Nov 2023 00:00:00 +030
Determining the level of food safety awareness by nutritional literacy in
health sciences faculty students
- Authors: Aliye Yaprak SEVİNÇ; Ülkü DEMİRCİ
  Abstract: Objectives: The aim of the research is to determine the nutrition literacy level and food safety awareness level of students who studied at faculty of health sciences. This descriptive study also demonstrates university students’ nutrition literacy statuses, food safety attitudes, nutritional statuses, and food preferences.Methods: The research was conducted as a descriptive and cross-sectional survey study in order to determine the nutrition literacy level and food safety awareness level of the students. Two hundred and eight individuals, including 174 women and 34 men, participated in the study. The data were obtained from face-to-face and online interviews then they were analyzed in a software. The survey is consisted of three parts: socio-demographic form, Evaluation Instrument of Nutrition Literacy on Adults and the Food Safety Attitude scale.Results: In this study, the majority of the participants studied in the department of nutrition and dietetics (55.29%) and audiology (26.92%), followed by health management (7.21%), physiology and rehabilitation (5.77%), nursing (4.33%) and social work (0.48%) department. The relationship between nutrition literacy and food safety among the students of the faculty of health sciences was significant (p < 0.01).Conclusions: This study showed that the nutrition literacy level was sufficient and the food safety attitude was positive in university students. However, it is needed to prospective studies to understand the importance of nutrition literacy and food safety awareness.
  PubDate: Sat, 04 Nov 2023 00:00:00 +030
Connective tissue disease related interstitial lung disease: a single
center experience
- Authors: Tahsin GEZGİN; Nurhan ATİLLA, Gözde YILDIRIM ÇETİN, Burcu AKKÖK, Fulsen BOZKUŞ, Betül KIZILDAĞ, Ali ÇULPAN, Hasan KAHRAMAN
  Abstract: Objectives: We aimed to determine the clinical features of the patients followed by our hospital with the diagnosis of connective tissue disease related interstitial lung disease (CTD-ILD).Methods: The study included 113 patients who were followed up with the diagnosis of CTD-ILD, admitted to Kahramanmaraş Sütçü İmam University, Faculty of Medicine, Rheumatology Department between January 2019 and December 2020. Demographic characteristics, laboratory data and high-resolution computed tomography (HRCT) patterns of the patients were recorded retrospectively.Results: Of 113 patients diagnosed with CTD-ILD; 90 were female, 23 were male. When the distribution of connective tissue disease (CTD) evaluated; 50 were rheumatoid arthritis, 41 were systemic sclerosis, 8 were sjogren's syndrome, 4 were systemic lupus erythematosus, 7 were overlap syndrome and 3 were undifferentiated connective tissue disease. There was no statistically significant difference between laboratory parameters. In the HRCT evaluation, 86 patients had nonspecific interstitial pneumonia (NSIP), 25 patients had usual interstitial pneumonia (UIP), and 2 patients had lymphocytic interstitial pneumonia (LIP) pattern. The most common pattern, including rheumatoid arthritis, was NSIP. Conclusions: In our study, as inconsistent with the literature the most common pattern in RA patients was found to be NSIP.
  PubDate: Sat, 04 Nov 2023 00:00:00 +030
Comparison of different plerixafor-based strategies for adequate
hematopoietic stem cell collection in poor mobilizers
- Authors: Sevil SADRİ; İpek YÖNAL HİNDİLERDEN, Yaşa Gül MUTLU, Tarık Onur TİRYAKİ, Ali İhsan GEMİCİ, Huseyin Saffet BEKOZ, Ömür GÖKMEN SEVİNDİK, Fehmi HİNDİLERDEN, Sevgi KALAYOĞLU-BEŞIŞIK, Meliha NALÇACI, Deniz SARGIN
  Abstract: Objectives: The main objective of the present study was to evaluate whether the use of plerixafor in combination with granulocyte colony-stimulating factor (G-CSF) or subsequent use of isolated G-CSF and then plerixafor following disease-specific chemotherapy, and whether it would allow for adequate peripheral stem cell collection in patients. Methods: The retrospective study evaluated 54 patients with previous mobilization failure who were administered plerixafor in 2 centers. In patients without any side effects, CD 34+ cell counts, the percentage of patients who were found eligible for autologous transplantation, the engraftment kinetics of the patients who underwent transplantation, and their overall survival results were compared between the two groups where G-CSF was used with plerixafor, or where plerixafor was used after isolated G-CSF following chemotherapy. Results: The median age of the patients was 49 years (range: 17-70), and 64.8% (n = 35) were males. It was identified that 31 (57.4%) patients underwent mobilization treatment with isolated G-CSF and plerixafor, and 23 (42.6%) patients underwent mobilization treatment with chemotherapy plus G-CSF and plerixafor. In all patients, mean hemoglobin level (11.3 ± 1.5 g/dL vs. 9.3 ± 1.3 g/dL; p < 0.001) and median platelet level (129.2 ×103/µL vs. 58.4 ×103/µL) were found to be higher, while febrile neutropenia rate (3.3% vs. 60.9%), the percentage of replacement patients (6.7% vs. 65.2%), and median days of G-CSF (6 vs. 9) were found to be lower on the day of plerixafor administration in the isolated G-CSF and plerixafor group compared to the chemotherapy and G-CSF and plerixafor group.Conclusions: In conclusion, our study demonstrated that administration of plerixafor is generally safe and well-tolerated. Regardless of the underlying disease, it offers an effective alternative for patients with previous failed mobilization attempts using conventional regimens, and allows stem cell collection with fewer apheresis sessions.
  PubDate: Sat, 04 Nov 2023 00:00:00 +030
Differential diagnosis for multiple systemic inflammatory syndrome in
children: clinical and laboratory clues
- Authors: Yüksel BICILIOĞLU; Tuğçe NALBANT, Alper ÇİÇEK, Esin ERGÖNÜL, Gamze GÖKALP, Gülsah DEMİR, Şefika BARDAK, Emel BERKSOY
  Abstract: Objectives: We aimed to identify biochemical markers and clinical findings with high sensitivity and specificity that can be used in the differential diagnosis of patients suspected of having Multisystem Inflammatory Syndrome in Children (MISC) in the pediatric emergency department (PED). Moreover, we also examined early warning signs for predicting severe MIS-C patients requiring admission to intensive care unit (ICU).Methods: We conducted a retrospective analysis of patients presenting to the PED with suspected MIS-C. Patient records were assessed for initial complaints, physical examination findings, laboratory and ımaging test results, diagnoses, and follow-up plans. Patients diagnosed with MIS-C were categorized as the MIS-C group, while others were categorized as the non-MIS-C group. Comparisons were made between these two groups.Results: A total of 266 patients were included, with 68 diagnosed with COVID-19-associated MIS-C, including 20 monitored in the pediatric ICU. MIS-C patients had higher mean age, hospitalization, and ICU admission rates compared to non-MIS-C. MIS-C group showed higher prevalence of respiratory symptoms, hematological involvement, and shock. We observed lymphopenia, thrombocytopenia, hyponatremia, and elevated levels of blood C-reactive protein (CRP), procalcitonin, triglycerides, troponin, Brain Natriuretic Peptide (BNP), D-dimer, and fibrinogen in the MIS-C group. ICU patients had higher procalcitonin, aspartate aminotransferase, alanine aminotransferase, triglycerides, troponin, BNP, and ferritin levels, and lower sodium levels.Conclusions: COVID-19-associated MIS-C group had higher rates of respiratory symptoms, hematological involvement, and shock. Lymphopenia, thrombocytopenia, elevated CRP, and D-dimer can guide MIS-C differential diagnosis. Additional tests (procalcitonin, troponin, BNP, triglycerides, ferritin) are recommended for high-suspicion cases. Patients with elevated BNP levels may require ICU admission.
  PubDate: Sat, 04 Nov 2023 00:00:00 +030
The relationship of epicardial fat and atrial high-rate episodes in
patients with permanent pacemaker
- Authors: Yusuf HOŞOĞLU; Fatih AKKAYA, Abdulkadir KIRIŞ
  Abstract: Objectives: Atrial high-rate episodes (AHRE) can occur in patients who have permanent pacemakers (PPM). AHRE is classified as subclinical atrial fibrillation (AF). Also, AHRE is related to clinical AF. Epicardial fat tissue (EFT) thickness is linked to AF. The purpose of this study was to examine the relation between AHRE and EFT thickness in PPM patients. Methods: Forty patients with dual-chamber PPM were enrolled. Transthoracic echocardiography was used to measure the thickness of the EFT. Patients were examined in 2 groups according to whether there was AHRE in the records: group 1 (AHRE) and group 2 (AHRE-free). A high atrial rate of more than 175 beats per minute for more than 5 minutes was defined as AHRE. The findings of the standard 2-dimensional echocardiography and the Doppler echocardiography were all recorded. A statistical relationship between EFT thickness and the development of AF was investigated.Results: Group 1 had ten patients, while Group 2 included thirty individuals. When the demographic features of the two groups were compared, they were similar. Both groups had similar 2-D echocardiographic and Doppler results. The difference in EFT thickness between groups 1 (2.0 ± 1.1 mm) and 2 (2.9 ± 1.8 mm) was not statistically significant (p = 0.138).Conclusions: In patients with PPM, AHRE may develop after implantation and may be detected asymptomatically in periodic follow-up. In this population, we did not observe a significant association between EFT thickness and the development of AF.
  PubDate: Sat, 04 Nov 2023 00:00:00 +030
Does prolonged QTc predict pulmonary involvement in COVID-19 patients'
- Authors: Aydın SARIHAN; Ömer Faruk RAHMAN, Serhat KORAN, Fatih AYTEMİZ, Çağdaş CAN, Fatih RAHMAN, Emre BULBUL
  Abstract: Objectives: Coronavirus disease (COVID-19) is a disease with high mortality due to acute respiratory distress syndrome (ARDS) secondary to viral pneumonia. In addition to its effects on the respiratory system, coronavirus is known to have serious systemic effects on the cardiovascular system. In this study, we aimed to investigate the association between prolonged QTc duration and COVID-19 specific pulmonary involvement Methods: Between December 2020 and February 2021, 112 patients who were diagnosed with COVID-19 in our COVID-19 outpatient clinic and met the inclusion criteria were evaluated for the association between cardiac variables (heart rate, PR width, QRS width, fQRS, and QTc interval), other patient characteristics and lung involvement.Results: A significant difference was found between the QTc intervals of COVID-19 patients with and without lung involvement (p < 0.026). In the ROC analysis for the QTc interval, which was found to be significant in the multivariate regression analysis, the cut-off value of 419.5 ms had a sensitivity of 72% and a specificity of 51.6% in predicting pulmonary involvement. Conclusions: Prolonged QTc duration may be useful in predicting COVID-19 pulmonary involvement in patients admitted to the emergency department.
  PubDate: Sat, 04 Nov 2023 00:00:00 +030
Fast platelet recovery is associated with remission in primary immune
thrombocytopenia
- Authors: Fatma GÜR HATİP; Demircan ÖZBALCI, Emine Güçhan ALANOĞLU, Ahmet Yunus HATİP
  Abstract: Objectives: We aimed to reveal predictors of response and response duration to steroid therapy in first line of treatment in immune thrombocytopenia (ITP).Methods: Fifty patients, who were diagnosed with ITP in hematology department of Suleyman Demirel University Hospital between 2005-2019, who had sufficient clinical and laboratory data, followed up for at least one year and received corticosteroid treatment in first line, were evaluated retrospectively for treatment response time, remission, prognosis on their first line treatment. The patients who maintained remission for more than 12 months was defined as group 1 and those who did not achieve remission or relapsed in less than 12 months were defined as group 2. Results: Twenty-two (44%) patients responded in first 3 days of the treatment, 16 (32%) patients in 4 to 7 days and 4 (8%) patients responded in more than 7 days. Eighty-four percent (n = 42) of these patients had complete response to corticosteroid treatment. When the remission maintenances were examined, it was observed that 22 (44%) patients were in remission for more than 12 months, 20 (40%) patients were in remission with treatment but relapsed before 12 months and 8 (16%) patients did not respond to corticosteroid treatment. When the response time to treatment in patients with or without remission was compared, remission was significantly lower in those who responded late to treatment (p = 0.01). When the response rates to corticosteroid treatment of patients in group 1 and 2 were evaluated, it was found that the response time to treatment was not related to the maintenance of remission (p = 0.267). Conclusions: Faster response time to treatment produced higher remission rates but, we could not find any relationship between response time to treatment and duration of remission.
  PubDate: Sat, 04 Nov 2023 00:00:00 +030
Investigation of Lactobacillus spp. bacteria in infants consuming breast
milk and formula and determination of some probiotic characters
- Authors: Tuğçe MUSLU ÇAĞAL; Esin KIRAY, Ergin KARİPTAŞ
  Abstract: Objectives: It was aimed to investigate some probiotic properties of Lactic Acid Bacteria (LAB) isolated from stool samples taken from 45 healthy 0-4 month old babies, who did not take antibiotics or probiotic supplements in the last 3 months, and who did not have any health problems. Methods: Six different species were obtained from 21 isolates selected by the method of Mass Spectrometry (MALDI-TOF MS).Results: The most common strain was Lactobacillus rhamnosus with a rate of 59%, followed by Lactobacillus paracasei with a rate of 13.6%. Vancomycin, tetracycline, gentamicin, netilmicin, tobramycin, penicillin, ampicillin, teicoplanin and amikacin antibiotics were used to evaluate the antimicrobial activities of the strains. In our study, while all strains were resistant to the antibiotic amikacin, they were sensitive to tetracycline, penicillin, gentamicin, netilmicin, teicoplanin, vancomycin, ampicillin and tobramycin antibiotics. In the evaluation of the antagonistic activities of LAB, 6 different pathogens (Escherichia coli ATCC 25922, Staphylococcus aureus ATCC 6538, Bacillus subtilis ATCC 6633, S. aureus ATCC 25923, Candida albicans ATCC 10231, Listeria monocytogenes ATCC 19111) were used and it was determined that the strains showed antimicrobial effects on all pathogenic microorganisms. Cholesterol assimilation abilities, T21 and T22 strains achieved the highest cholesterol assimilation rate of 39.1%. Conclusions: It is thought that most of the isolated strains have probiotic potential, and especially Lactobacillus gasseri T21 and L. paracasei T22 strains may be probiotic strains that can be used in the production of preparations alone or together with other Lactobacillus strains.
  PubDate: Sat, 04 Nov 2023 00:00:00 +030
Do anxiety levels and attitudes towards COVID-19 vaccines among healthcare
workers change after COVID-19 vaccination'
- Authors: Hasan BALABAN; Meltem DEMİRDAĞ ÇEVİKKAN, Selin TANYERİ KAYAHAN
  Abstract: Objectives: The COVID-19 pandemic has significant effects on the mental health of societies and individuals worldwide while especially for healthcare workers these effects pose a higher risk due to occupational exposure. COVID-19 vaccines have been a turning point in the pandemic, however concepts as vaccine hesitancy and anti-vaccination have come into question again. This study aimed to comparatively evaluate the attitudes of healthcare professionals towards the COVID-19 vaccines, their pandemic-related anxiety and phobia levels before and after vaccination.Methods: In this cross-sectional study, the anxiety levels and attitudes towards COVID-19 vaccines of healthcare professionals working in a state hospital were evaluated by administrating Coronavirus Anxiety Scale (CAS), Coronavirus-19 Phobia Scale (CP19-S), and Attitudes Towards COVID-19 Vaccine Scale (ATV-COVID-19) to the participants both in the pre-vaccine (n = 154) and post-vaccine (n = 81) periods. All these scales were previously validates in Turkish population. 44.8% (n = 69) of pre-vaccine sample and 45.7% (n = 37) of post-vaccine sample were female and all participants were Turkish. Participants were questioned about COVID-19 symptoms during each application and kept in touch in terms of side effects.Results: One hundres fifty-four pre-vaccine and 81 post-vaccine health workers were included in the study. After the vaccination scores of CAS and CP19-S decreased significantly compared to the pre-vaccine period (p < 0.001 and p = 0.005, respectively); while ATV-COVID-19 scores significantly increased (p < 0.001). Participants did not report significant adverse events in the post-vaccine period.Conclusions: The results of the study in the form of a decrease in anxiety and fear levels and an increase in positive attitudes towards the vaccine after vaccination suggest that vaccination may have a positive effect on the mental health of healthcare workers.
  PubDate: Sat, 04 Nov 2023 00:00:00 +030
Cystic fibrosis diagnosed in a nineteen-year-old case
- Authors: Meltem YILMAZ; Levent MUTLU
  Abstract: Cystic fibrosis is the most common autosomal recessive hereditary disease in white populations. It is characterized by the formation of abnormal secretions in the exocrine glands located in the sweat and salivary glands, tracheobronchial tree, large intestine, and pancreas. The severity of the clinic depends on the type of "cystic fibrosis transmembrane regulatory protein" gene mutation. Although most cases are diagnosed in infancy or childhood, some patients are also diagnosed during adolescence and adulthood. We report a case of a 19-year-old patient who was followed up with a diagnosis of asthma and bronchiectasis since childhood and diagnosed with cystic fibrosis.
  PubDate: Sat, 04 Nov 2023 00:00:00 +030
Assessment of the knowledge and use of hypertonic saline among doctors
working in paediatrics departments of tertiary institutions in the five
states of South-East Nigeria
- Authors: Ikenna NDU; Benedict EDELU, Kenechukwu ILOH, Obinna NDUAGUBAM, Chukwunonso Chıgozıe IHEJI, Chijioke EZEUDU, Joseph EZEOGU, Obianuju Ojinika IGBOKWE, Ogochukwu Nneka ILOH, Oluchi Mildred IZUKA, Linda NWOKEJİ-ONWE, Ngozi ONU
  Abstract: Objectives: This study aimed to evaluate the knowledge and use of hypertonic saline among doctors in the Southeast region of Nigeria.Methods: It was a cross-sectional study conducted amongst 182 doctors in the paediatric departments of the six tertiary institutions in South Eastern Nigeria. Data to assess knowledge and use of hypertonic saline were collected using self-administered, structured questionnaires.Results: After aggregating the knowledge questions (definition of hypertonic saline, knowledge of available concentrations and modes of administration) and categorizing knowledge into good or poor, 148 (81.3%) had good knowledge, while 34 (18.7%) had poor knowledge. Respondents who had ever seen an infusion of hypertonic saline were 93 (51.1%), while only 62 (34.1%) had ever used it during their practice. Among those who had used it, only 33 (18.1%) obtained it from their hospital pharmacy. Most respondents (91.2%) would support advocacy for its increased availability and use in Nigeria.Conclusions: Our study demonstrated good knowledge of hypertonic saline, however, there is low usage due to unavailability. There is a need for collaboration between paediatricians, pharmaceutical companies and other stakeholders to create demand and initiate the production of hypertonic saline.
  PubDate: Sat, 04 Nov 2023 00:00:00 +030
Relationship between emotional intelligence and prenatal attachment levels
of women with healthy and high-risk pregnancies
- Authors: Meltem MECDİ KAYDIRAK; Nil KÜÇÜK YÜCEYURT, Zuhal ERTÜRK, Ümran OSKAY
  Abstract: Objectives: Emotional intelligence enables pregnant women to effectively cope with environmental effects and stressors in a dynamic and changing process. This research was planned for evaluating the relationship between emotional intelligence and prenatal attachment levels of women with healthy and high-risk pregnancies. Methods: Based on the descriptive research design and regression analysis, the research was performed with the participation of 281 pregnant women. Research data were collected through Information Form, Emotional Intelligence Self-Evaluation Scale (EISES) and Prenatal Attachment Inventory (PAI). Results: As per means of scores obtained from the EISES and PAI by women with healthy (133.34 ± 32.30) and high-risk (126.81 ± 35.80) pregnancies, it was found that pregnant women had high levels of emotional intelligence and medium levels of prenatal attachment. Based on research variables, there were no statistically significant differences in means of scores obtained from the Scale and the Inventory by women with healthy and high-risk pregnancies (p > 0.05). It was found that women who voluntarily got pregnant had higher prenatal attachment levels and this difference was statistically significant (x2= 102.81, p < 0.001). It was identified that there was no statistically significant difference in means of scores obtained by pregnant women from the EISES ans PAI (r= -0.060, p = 0.318). Conclusions: It was found that there was no statistically significant difference in prenatal attachment levels of women with healthy and high-risk pregnancies and their prenatal attachment levels had no statistically significant association with their emotional intelligence levels.
  PubDate: Sat, 04 Nov 2023 00:00:00 +030
The possible effects of COVID-19 on the human reproductive system
- Authors: Tuğba DAĞDEVİREN; Hatice Kübra YOLCU
  Abstract: Spike surface glycoprotein and small envelope matrix-nucleocapsid proteins, is from the Coronaviridae family and binds to host receptors via spike surface proteins. Although it shows its symptoms especially on the respiratory tract, various studies have been carried out considering that it also affects other systems in the body. For the virus to enter the host cell, it must bind to ACE2 (angiotensin converting enzyme 2). ACE2 is a key protein involved in balancing Ang I and Ang II levels. With receptors such as TMPRSS2 (transmembrane serine protease 2), the effects of the virus on the human reproductive system are much better understood. Since human germ cells and early embryos express ACE2, there is a potential risk of the Coronavirus associated with germ cells. Studies show that the coronavirus changes the amount and density of hormones in the human reproductive system. The fact that most of the partners of 35 female patients who had SARS-CoV-2 in the studies were infected individuals suggests that sexual transmission may be possible. It was determined that TMPRSS4, Cathepsin B and L, FURIN, MX1 and BSG gene expressions were high in the menstrual cycle, while ACE 2 and TMPRSS2 were moderately expressed. It has been shown that the ACE2 enzyme is most intensely expressed is the testes. Studies have shown that sperm DNA (deoxyribonucleic acid) fragmentation, changes in hormone levels and the formation of anti-sperm antibodies are an important cause of male infertility. Infected men have been found to have an impaired spermatogenesis. This rewiew; it aims to draw attention to the possible effects of the corona virus on the human reproductive system and to reveal new mechanisms for new research to be done.
  PubDate: Sat, 04 Nov 2023 00:00:00 +030
Tracheobronchopathia osteochondroplastica limited to the trachea: a case
report and rewiew of literature
- Authors: Ahmet Bülent KARGI; Eray ATLI, Bilge KILIÇ, Pelin BİLGİN
  Abstract: Tracheobronchopathia Osteochondroplastica (TO) is a rare and benign disease with a progressive course. Its clinical manifestation is observed on computed tomography by the presence of diffuse osteocartilage submucosal nodules invading the lumen of the trachea and usually the main bronchi. Bronchoscopic evaluation is necessary for differential diagnosis. Standard treatment has not been determined as few patients have been reported in the literature. A 58-year-old male patient was admitted to our hospital with complaints of cough and dyspnea increasing with exertion. A fiberoptic bronchoscopy demonstrated many protruding lesions along the trachea with no involvement of the bronchial system. The patient was stable at a two-year follow-up.
  PubDate: Sat, 04 Nov 2023 00:00:00 +030
Assessment of chiropractic intervention influence on pain and life quality
in cervicogenic headache afflicted office workers: a review
- Authors: Seyfettin Emrecan ILTER; Alper GÖKÇE
  Abstract: Cervicogenic headache, characterized by referred pain perceived in the head but originating from the cervical spine, is a prevalent non-migraine headache impacting a significant proportion of the global population, particularly office workers. Recent studies have identified a co-occurrence of cervicogenic headaches with neck pain, often exacerbated by long hours of stationary sitting and computer use common in desk jobs. Despite the growing evidence supporting the effectiveness of chiropractic treatment in mitigating head and neck pain, a distinct gap persists in the literature concerning chiropractic interventions specifically targeting office workers suffering from cervicogenic headaches. This review aims to scrutinize the current literature on the effectiveness of chiropractic interventions on pain management and life quality improvement for office workers afflicted with cervicogenic headaches. Specifically, the review will delve into high-velocity, low-amplitude (HVLA) thrust maneuvers, a widely employed strategy in spinal manipulative therapy, an extension of chiropractic treatment. In the context of cervicogenic headaches, the link between the Rectus Capitis Posterior Minor (RCPM) muscle and the Dura Mater, and how neck strains affecting this connection can instigate headaches, will be explored. Through the comprehensive evaluation of existing literature and studies, this review seeks not only to elucidate the potential of chiropractic treatment in improving the life quality of office workers suffering from cervicogenic headaches, but also to stimulate further research in this essential yet under-explored area of study.
  PubDate: Sat, 04 Nov 2023 00:00:00 +030
Renal artery stenosis: a single center experience
- Authors: Yavuz AYAR; Barış DÖNER, Suat AKGÜR, Mustafa İŞLEYEN, Gökhan OCAKOĞLU
  Abstract: Objectives: Renal artery stenosis (RAS) is among the most common causes of secondary hypertension. Prevalence of RAS are seen in end-stage renal disease (ESRD) patients with hypertension between 1-10%. In our study, we evaluated the data of patients with RAS who were followed up with medical treatment and stenting.Methods: In our study, patients who were thought to have renal artery stenosis (RAS) with renal artery doppler ultrasonography were scanned with contrast-enhanced Magnetic Resonance Angiography (MRA). Fifty-three patients (10 received medical therapy, 43 applied invasive procedure) who diagnosed with RAS evaluated. Results: Follow-up times were 15 (12-84) months in patients who received medical therapy, and 12 (10-96) months in patients who treated with invasive therapy (p = 0.583). Median ages were 56 (19-74) years in medical treatment group, and 60 (15-77) years in invasive therapy group (p = 0.955). Compared with the beginning of treatment, diastolic hypertension was decreased of 12.5% in invasive treatment group opposite medical therapy group (p = 0.040), so eGFR was increased of 5.94% in invasive treatment group. Conclusions: In recent years, several studies about survival in patients with RAS was observed that there was no significant difference between the medical and invasive treatment. Clinical, laboratory, and individual characteristics should be considered in treatment choice.
  PubDate: Sat, 04 Nov 2023 00:00:00 +030