Subjects -> MEDICAL SCIENCES (Total: 8212 journals)
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MEDICAL SCIENCES (2241 journals)                  1 2 3 4 5 6 7 8 | Last

Showing 1 - 200 of 3562 Journals sorted alphabetically
16 de Abril     Open Access   (Followers: 1)
3D Printing in Medicine     Open Access   (Followers: 5)
4 open     Open Access  
AADE in Practice     Hybrid Journal   (Followers: 2)
AAS Open Research     Open Access  
ABCS Health Sciences     Open Access   (Followers: 3)
Abia State University Medical Students' Association Journal     Full-text available via subscription   (Followers: 1)
AboutOpen     Open Access  
ACIMED     Open Access  
ACM Transactions on Computing for Healthcare     Hybrid Journal  
ACS Medicinal Chemistry Letters     Hybrid Journal   (Followers: 42)
Acta Bio Medica     Open Access   (Followers: 1)
Acta Bioethica     Open Access  
Acta Bioquimica Clinica Latinoamericana     Open Access   (Followers: 1)
Acta Herediana     Open Access  
Acta Marisiensis - Seria Medica     Open Access  
Acta Medica (Hradec Králové)     Open Access  
Acta Medica Bulgarica     Open Access  
Acta Medica Colombiana     Open Access   (Followers: 1)
Acta Médica Costarricense     Open Access   (Followers: 2)
Acta Medica Indonesiana     Open Access  
Acta Medica International     Open Access  
Acta Medica Iranica     Open Access  
Acta medica Lituanica     Open Access  
Acta Medica Martiniana     Open Access  
Acta Medica Peruana     Open Access   (Followers: 1)
Acta Scientiarum. Health Sciences     Open Access   (Followers: 2)
Acupuncture & Electro-Therapeutics Research     Full-text available via subscription   (Followers: 3)
Acupuncture and Herbal Medicine     Open Access   (Followers: 1)
Addiction Science & Clinical Practice     Open Access   (Followers: 9)
Addictive Behaviors Reports     Open Access   (Followers: 8)
Adıyaman Üniversitesi Sağlık Bilimleri Dergisi / Health Sciences Journal of Adıyaman University     Open Access  
Adnan Menderes Üniversitesi Sağlık Bilimleri Fakültesi Dergisi     Open Access  
Advanced Health Care Technologies     Open Access   (Followers: 12)
Advanced NanoBiomed Research     Open Access   (Followers: 1)
Advanced Science, Engineering and Medicine     Partially Free   (Followers: 4)
Advanced Therapeutics     Hybrid Journal   (Followers: 1)
Advances in Bioscience and Clinical Medicine     Open Access   (Followers: 6)
Advances in Cell and Gene Therapy     Hybrid Journal   (Followers: 1)
Advances in Clinical Chemistry     Full-text available via subscription   (Followers: 24)
Advances in Clinical Radiology     Full-text available via subscription   (Followers: 4)
Advances in Life Course Research     Hybrid Journal   (Followers: 7)
Advances in Medical Education and Practice     Open Access   (Followers: 29)
Advances in Medical Sciences     Hybrid Journal   (Followers: 7)
Advances in Medicine     Open Access   (Followers: 3)
Advances in Microbial Physiology     Full-text available via subscription   (Followers: 3)
Advances in Parkinson's Disease     Open Access   (Followers: 2)
Advances in Preventive Medicine     Open Access   (Followers: 6)
Advances in Protein Chemistry and Structural Biology     Full-text available via subscription   (Followers: 18)
Advances in Regenerative Medicine     Open Access   (Followers: 3)
Advances in Therapy     Hybrid Journal   (Followers: 5)
Advances in Traditional Medicine     Hybrid Journal   (Followers: 3)
Advances in Virus Research     Full-text available via subscription   (Followers: 7)
Advances in Wound Care     Hybrid Journal   (Followers: 14)
Aerospace Medicine and Human Performance     Full-text available via subscription   (Followers: 22)
African Health Sciences     Open Access   (Followers: 6)
African Journal of Biomedical Research     Open Access  
African Journal of Clinical and Experimental Microbiology     Open Access  
African Journal of Laboratory Medicine     Open Access   (Followers: 2)
African Journal of Medical and Health Sciences     Open Access  
Afrimedic Journal     Open Access   (Followers: 3)
AIDS Research and Human Retroviruses     Hybrid Journal   (Followers: 9)
Airway     Open Access   (Followers: 3)
AJOB Empirical Bioethics     Hybrid Journal   (Followers: 3)
AJSP: Reviews & Reports     Hybrid Journal  
Aktuelle Ernährungsmedizin     Hybrid Journal   (Followers: 4)
AkupunkturPraxis     Full-text available via subscription   (Followers: 3)
Al-Azhar Assiut Medical Journal     Open Access   (Followers: 1)
Al-Qadisiah Medical Journal     Open Access  
Alerta : Revista Científica del Instituto Nacional de Salud     Open Access  
Alexandria Journal of Medicine     Open Access  
Allgemeine Homöopathische Zeitung     Hybrid Journal   (Followers: 1)
ALTEX : Alternatives to Animal Experimentation     Open Access   (Followers: 1)
American Journal of Biomedical Engineering     Open Access   (Followers: 10)
American Journal of Biomedical Research     Open Access   (Followers: 2)
American Journal of Biomedicine     Full-text available via subscription  
American Journal of Chinese Medicine, The     Hybrid Journal   (Followers: 2)
American Journal of Clinical Medicine Research     Open Access   (Followers: 5)
American Journal of Family Therapy     Hybrid Journal   (Followers: 6)
American Journal of Law & Medicine     Full-text available via subscription   (Followers: 10)
American Journal of Lifestyle Medicine     Hybrid Journal   (Followers: 5)
American Journal of Managed Care     Full-text available via subscription   (Followers: 13)
American Journal of Medical Case Reports     Open Access  
American Journal of Medical Sciences and Medicine     Open Access   (Followers: 2)
American Journal of Medicine     Hybrid Journal   (Followers: 47)
American Journal of Medicine and Medical Sciences     Open Access   (Followers: 1)
American Journal of Medicine Open     Open Access   (Followers: 3)
American Journal of Medicine Studies     Open Access   (Followers: 3)
American Journal of Medicine Supplements     Full-text available via subscription   (Followers: 3)
American Journal of the Medical Sciences     Hybrid Journal   (Followers: 11)
American Journal on Addictions     Hybrid Journal   (Followers: 11)
American medical news     Free   (Followers: 3)
Amrita Journal of Medicine     Open Access   (Followers: 3)
Amyloid: The Journal of Protein Folding Disorders     Hybrid Journal   (Followers: 6)
Anales de la Facultad de Medicina     Open Access  
Anales de la Facultad de Medicina, Universidad de la República, Uruguay     Open Access  
Anales del Sistema Sanitario de Navarra     Open Access   (Followers: 1)
Analgesia & Resuscitation : Current Research     Hybrid Journal   (Followers: 5)
Anatolian Clinic the Journal of Medical Sciences     Open Access  
Anatomica Medical Journal     Open Access  
Anatomical Science International     Hybrid Journal   (Followers: 3)
Anatomical Sciences Education     Hybrid Journal   (Followers: 1)
Anatomy     Open Access   (Followers: 3)
Anatomy Research International     Open Access   (Followers: 4)
Androgens : Clinical Research and Therapeutics     Open Access  
Angewandte Nuklearmedizin     Full-text available via subscription   (Followers: 3)
Angewandte Schmerztherapie und Palliativmedizin     Hybrid Journal  
Angiogenesis     Hybrid Journal   (Followers: 2)
Animal Diseases     Open Access   (Followers: 1)
Annales de Pathologie     Full-text available via subscription  
Annales françaises d'Oto-rhino-laryngologie et de Pathologie Cervico-faciale     Full-text available via subscription   (Followers: 2)
Annals of 3D Printed Medicine     Open Access  
Annals of African Medicine     Open Access   (Followers: 2)
Annals of Anatomy - Anatomischer Anzeiger     Hybrid Journal   (Followers: 2)
Annals of Biomedical Engineering     Hybrid Journal   (Followers: 18)
Annals of Biomedical Sciences     Full-text available via subscription   (Followers: 3)
Annals of Clinical and Medical Case Reports     Open Access  
Annals of Clinical Hypertension     Open Access  
Annals of Clinical Microbiology and Antimicrobials     Open Access   (Followers: 9)
Annals of Family Medicine     Open Access   (Followers: 14)
Annals of Health Research     Open Access   (Followers: 2)
Annals of Ibadan Postgraduate Medicine     Open Access  
Annals of Medical and Health Sciences Research     Open Access   (Followers: 5)
Annals of Medicine     Hybrid Journal   (Followers: 11)
Annals of Medicine and Surgery     Open Access   (Followers: 7)
Annals of Medicine and Surgery Case Reports     Open Access   (Followers: 1)
Annals of Medicine and Surgery Protocols     Open Access  
Annals of Microbiology     Open Access   (Followers: 9)
Annals of Musculoskeletal Medicine     Open Access  
Annals of Rehabilitation Medicine     Open Access   (Followers: 1)
Annals of Saudi Medicine     Open Access  
Annals of the College of Medicine, Mosul     Open Access  
Annals of the National Academy of Medical Sciences (India)     Open Access  
Annals of the New York Academy of Sciences     Hybrid Journal   (Followers: 5)
Annals of The Royal College of Surgeons of England     Full-text available via subscription   (Followers: 3)
Annals of the RussianAacademy of Medical Sciences     Open Access  
Annals of Vascular Surgery - Brief Reports and Innovations     Full-text available via subscription  
Annual Reports in Medicinal Chemistry     Full-text available via subscription   (Followers: 6)
Annual Reports on NMR Spectroscopy     Full-text available via subscription   (Followers: 4)
Annual Review of Medicine     Full-text available via subscription   (Followers: 18)
Anthropological Review     Open Access   (Followers: 27)
Anthropologie et santé     Open Access   (Followers: 4)
Antibiotics     Open Access   (Followers: 10)
Antibodies     Open Access   (Followers: 2)
Antibody Reports     Open Access  
Antibody Therapeutics     Open Access  
Anuradhapura Medical Journal     Open Access  
Anwer Khan Modern Medical College Journal     Open Access  
Apmis     Hybrid Journal   (Followers: 1)
Apparence(s)     Open Access   (Followers: 1)
Applied Clinical Informatics     Hybrid Journal   (Followers: 4)
Applied Medical Informatics     Open Access   (Followers: 11)
Arab Journal of Nephrology and Transplantation     Open Access   (Followers: 2)
Arabian Journal of Scientific Research / المجلة العربية للبحث العلمي     Open Access  
Archive of Biomedical Science and Engineering     Open Access  
Archive of Clinical Medicine     Open Access   (Followers: 1)
Archives Medical Review Journal / Arşiv Kaynak Tarama Dergisi     Open Access  
Archives of Asthma, Allergy and Immunology     Open Access   (Followers: 1)
Archives of Clinical Hypertension     Open Access  
Archives of Medical and Biomedical Research     Open Access   (Followers: 2)
Archives of Medical Laboratory Sciences     Open Access  
Archives of Medicine and Health Sciences     Open Access   (Followers: 5)
Archives of Organ Transplantation     Open Access  
Archives of Preventive Medicine     Open Access  
Archives of Pulmonology and Respiratory Care     Open Access  
Archives of Renal Diseases and Management     Open Access  
Archives of Trauma Research     Open Access   (Followers: 4)
Arquivos de Medicina     Open Access  
Ars Medica : Revista de Ciencias Médicas     Open Access  
ARS Medica Tomitana     Open Access  
Art Therapy: Journal of the American Art Therapy Association     Hybrid Journal   (Followers: 14)
Arterial Hypertension     Open Access  
Artificial Intelligence in Medicine     Hybrid Journal   (Followers: 19)
Artificial Organs     Hybrid Journal   (Followers: 1)
ASA Monitor     Full-text available via subscription   (Followers: 1)
Asia Pacific Journal of Clinical Nutrition     Full-text available via subscription   (Followers: 10)
Asian Bioethics Review     Full-text available via subscription   (Followers: 2)
Asian Journal of Cell Biology     Open Access   (Followers: 4)
Asian Journal of Health     Open Access   (Followers: 3)
Asian Journal of Medical and Biological Research     Open Access   (Followers: 3)
Asian Journal of Medical and Pharmaceutical Researches     Open Access  
Asian Journal of Medical Sciences     Open Access   (Followers: 2)
Asian Journal of Medicine and Health     Open Access   (Followers: 1)
Asian Journal of Population Sciences     Open Access   (Followers: 1)
Asian Journal of Research in Medical and Pharmaceutical Sciences     Open Access  
Asian Journal of Scientific Research     Open Access   (Followers: 2)
Asian Journal of Social Health and Behavior     Open Access   (Followers: 3)
Asian Journal of Transfusion Science     Open Access  
Asian Medicine     Hybrid Journal   (Followers: 5)
Asian Pacific Journal of Health Sciences     Open Access   (Followers: 2)
ASPIRATOR : Journal of Vector-borne Disease Studies     Open Access  
Atención Primaria     Open Access   (Followers: 2)
Atención Primaria Práctica     Open Access  
Atti della Accademia Peloritana dei Pericolanti - Classe di Scienze Medico-Biologiche     Open Access  
Auris Nasus Larynx     Full-text available via subscription  
Australasian Journal of Ultrasound in Medicine (AJUM)     Hybrid Journal   (Followers: 1)
Australian Family Physician     Full-text available via subscription   (Followers: 3)
Australian Journal of Medical Science     Full-text available via subscription   (Followers: 4)
Autopsy and Case Reports     Open Access  
Avicenna     Open Access   (Followers: 1)

        1 2 3 4 5 6 7 8 | Last

Similar Journals
Journal Cover
Astrocyte
Number of Followers: 0  

  This is an Open Access Journal Open Access journal
ISSN (Print) 2349-0977 - ISSN (Online) 2349-4387
This journal is no longer being updated because:
    The journal ceased publication
  • Clinical neurosciences: Where do we go from here?

    • Authors: Yatish Agarwal, Rashmikant Dave
      Pages: 1 - 4
      Abstract: Yatish Agarwal, Rashmikant Dave
      Astrocyte 2018 5(1):1-4

      Citation: Astrocyte 2018 5(1):1-4
      PubDate: Mon,28 Jan 2019
      DOI: 10.4103/2349-0977.250951
      Issue No: Vol. 5, No. 1 (2019)
       
  • Unravelling the exciting new therapeutic pathways in clinical neurology

    • Authors: Majaz Moonis
      Pages: 5 - 9
      Abstract: Majaz Moonis
      Astrocyte 2018 5(1):5-9

      Citation: Astrocyte 2018 5(1):5-9
      PubDate: Mon,28 Jan 2019
      DOI: 10.4103/2349-0977.250926
      Issue No: Vol. 5, No. 1 (2019)
       
  • The neurology timeline: Of demon holes, sacred pathways and great triumphs

    • Authors: Yatish Agarwal, Pranav Ish, Neera Chaudhry, Ravinder S Sethi
      Pages: 10 - 25
      Abstract: Yatish Agarwal, Pranav Ish, Neera Chaudhry, Ravinder S Sethi
      Astrocyte 2018 5(1):10-25
      The first chapter in neurology was composed in the prescience era. Chiseled with flint stones, grisly in nature, it was a narrative where men trephined human skull to treat such maladies as head injury, epilepsy, and disturbed mind. The ungodly practice survived from the late Stone Age until the renaissance. The first written reference to brain is found in the Edwin Smith surgical papyri. Written around 3000 BCE in Egypt, the papyri describe certain cognitive defects of head injuries. The first sapient exploration into the functions and diseases of brain opened in the sixth to fourth century BCE. It began with the Alexandrian anatomists and Hippocratic doctors, gathered steam in the classical era of science with Galen in the first century, and reached its peak with Vesalius during renaissance. Modern neurology, particularly the localization of brain functions, began with German physician Franz Joseph Gall's work on phrenology in the late 18th century and, over the next hundred years, was followed by the discovery of language, motor, and sensory cortical areas. The idea that the nervous system is made up of discrete nerve cells was born out of the neuroanatomical work of Camillo Golgi and a Spanish doctor, Santiago Ramón y Cajal, at the end of 19th century. Major 20th-century developments include advances in understanding of the frontal lobes, the role of visual cortex in perception, the function of hippocampus in memory, lateralization of cortical function, and the introduction of all revealing cross-sectional and functional imaging. While practitioners of medicine across the world unraveled the secrets of maladies that strike the seat of senses and intellect, other accomplished players struck sweet melodies of life by discovering potent molecules, devices, and surgical techniques which could work a remedy and cure.
      Citation: Astrocyte 2018 5(1):10-25
      PubDate: Mon,28 Jan 2019
      DOI: 10.4103/2349-0977.250925
      Issue No: Vol. 5, No. 1 (2019)
       
  • Stroke in the young: Newer concepts in etiopathogenesis and risk factors

    • Authors: Man Mohan Mehndiratta, Prachi Mehndiratta
      Pages: 26 - 32
      Abstract: Man Mohan Mehndiratta, Prachi Mehndiratta
      Astrocyte 2018 5(1):26-32
      Background: Stroke in young has become one of the major causes of mortality & morbidity lately. Incidence of stroke in young is on the rise. Recent studies show young stroke being one of the important differential diagnoses for any kind of acute lateralised neurological deficits in younger population. Along with various traditional risk factors, there are some emerging vascular, genetic and others unidentified risk factors implicated in the etiopathogenesis of stroke in young. Burden of the disease along with major long term socioeconomic impacts at the patients, their family & society level are enormous. Objective: Recognition of underlying vascular & genetic risk factors may improve physician's awareness & optimise the outcomes in young stroke patients. Recent advances in the imaging technologies and genetic testing may help the experts to develop effective guidelines for the prevention and treatment of young stroke patients. Conclusion: Considering the increasing burden of the disease, standardised methodology along with more research works have become an imperative need of time in order to decrease the morbidity & mortality in young stroke patients.
      Citation: Astrocyte 2018 5(1):26-32
      PubDate: Mon,28 Jan 2019
      DOI: 10.4103/astrocyte.astrocyte_48_18
      Issue No: Vol. 5, No. 1 (2019)
       
  • Current strategies in stroke therapy: Temporality, pharmacological agents
           and endovascular treatments

    • Authors: Yunis Mayasi, Brian Silver
      Pages: 33 - 38
      Abstract: Yunis Mayasi, Brian Silver
      Astrocyte 2018 5(1):33-38
      Stroke, a leading cause of morbidity and mortality, remains an active venue for discovery. Advances in stroke neurology include prevention, treatment, and detection, in addition to rehabilitation. In terms of treatment, vast strides have been taken since the five major intra-arterial treatment trials, with extension of the treatment window in addition to the use of imaging for better patient selection. Treatment of hemorrhagic stroke has also improved in the past decade with better understanding of the pathophysiology of the disease, establishment of guidelines for blood pressure control and monitoring, treatment of coagulopathies in addition to surgical interventions. Several ongoing trials are being conducted to further elucidate the utility and efficacy of minimally invasive surgical options in deep intracranial hemorrhage.
      Citation: Astrocyte 2018 5(1):33-38
      PubDate: Mon,28 Jan 2019
      DOI: 10.4103/astrocyte.astrocyte_49_18
      Issue No: Vol. 5, No. 1 (2019)
       
  • Post stroke restorative therapies: Drugs, devices and robotics

    • Authors: MV Padma Srivastava, Ashu Bhasin
      Pages: 39 - 42
      Abstract: MV Padma Srivastava, Ashu Bhasin
      Astrocyte 2018 5(1):39-42
      Restorative therapies in neurology aim to improve outcome and function by promoting plasticity within a therapeutic time window between days to weeks to years. In this article, the mechanisms by which cell-based, pharmacological and robotic treatments stimulate endogenous brain remodeling after stroke, particularly neurogenesis, axonal plasticity, and white-matter integrity, are described with a brief outline of the potential of neuroimaging (functional magnetic resonance imaging) techniques. Stem cells aid stroke recovery through mechanisms depending on the type of cells used. Transplanted embryonic stem cells, induced pluripotent cells, and neural stem cells can replace the missing brain cells in the infarcted area, whereas adult stem cells, such as multipotent stromal cells and mononuclear cells, provide trophic support to enhance self-repair systems such as endogenous neurogenesis. Noninvasive brain stimulation provides a valuable tool for interventional neurophysiology by modulating brain activity in a specific distributed, corticosubcortical network. Elucidating the underlying mechanisms of cell-based, pharmacological and rehabilitative therapies is of primary interest and crucial for translation of treatments to clinical use. This will provide an impetus for the development of superior, advanced, and cost-effective neurorestorative interventions that will enhance stroke recovery.
      Citation: Astrocyte 2018 5(1):39-42
      PubDate: Mon,28 Jan 2019
      DOI: 10.4103/astrocyte.astrocyte_50_18
      Issue No: Vol. 5, No. 1 (2019)
       
  • Multiple sclerosis: Newer concepts on pathophysiology, diagnostic criteria
           and therapeutics

    • Authors: Rohit Bhatia, Nishita Singh
      Pages: 43 - 54
      Abstract: Rohit Bhatia, Nishita Singh
      Astrocyte 2018 5(1):43-54
      Multiple sclerosis (MS) is a challenging and disabling demyelinating disorder, presumed to be of autoimmune origin. Various environmental and genetic risk factors have now been implicated in the etiopathogenesis of this disorder. Early and precise diagnosis is critical and is supported by use of recent revision of diagnostic criteria, incorporating imaging and spinal fluid abnormalities. Notably, the treatment armamentarium for MS has expanded substantially over the last two decades with approval of newer drugs and many other drugs in terminal stages of development. However, some of these therapies are associated with long-term effects on immune system and/or severe adverse events which can complicate ensuing therapies. The customisation of treatment requires consideration of many factors like safety, efficacy, patient related factors and finally a comprehensive risk-benefit assessment for an individual patient. This article is intended to help make informed ecisions, keep realistic goals and raising cognizance of multiple factors involved in treating patients with MS.
      Citation: Astrocyte 2018 5(1):43-54
      PubDate: Mon,28 Jan 2019
      DOI: 10.4103/astrocyte.astrocyte_51_18
      Issue No: Vol. 5, No. 1 (2019)
       
  • Movement disorders: Current understanding of pathophysiology and
           management

    • Authors: Madhuri Behari, Abhilekh Srivastava
      Pages: 55 - 62
      Abstract: Madhuri Behari, Abhilekh Srivastava
      Astrocyte 2018 5(1):55-62
      In the last four decades, great strides have been made in understanding the pathophysiology and management of movement disorders. Several new molecules and methods of their delivery have made management of these disorders free of complications. New discoveries of genetic abnormalities have helped in better classification of these disorders along with improved prognostication. Improved imaging techniques that help in better localization of target for deep brain stimulation, refinement of stereotactic procedure, and development of safer anesthetic procedure have together encouraged more patients opting for deep brain stimulation for treatment. In the near future, it is expected that more genetic varieties of disorders will be known which may help in genetic intervention for therapy.
      Citation: Astrocyte 2018 5(1):55-62
      PubDate: Mon,28 Jan 2019
      DOI: 10.4103/astrocyte.astrocyte_52_18
      Issue No: Vol. 5, No. 1 (2019)
       
  • Cross linkage between quality of sleep and neurologic conditions in
           age-diverse populations

    • Authors: Anne Marie Morse, Sanjeev V Kothare
      Pages: 63 - 73
      Abstract: Anne Marie Morse, Sanjeev V Kothare
      Astrocyte 2018 5(1):63-73
      Sleep medicine is inextricably interwoven with neurological health, be it in the young, adult, or geriatric population. Recent studies have highlighted its clinical benefit in autism, attention deficit hyperactivity disorder, traumatic brain injury, headache, epilepsy, multiple sclerosis, neuromuscular disease, stroke, and Alzheimer's disease. The tool of sleep health optimization may provide significant benefit and transform outcome and prognosis, and may also help yield a greater insight into many of these neurologic conditions.
      Citation: Astrocyte 2018 5(1):63-73
      PubDate: Mon,28 Jan 2019
      DOI: 10.4103/astrocyte.astrocyte_53_18
      Issue No: Vol. 5, No. 1 (2019)
       
  • The antiepileptics: Drug choice in newly diagnosed epilepsy

    • Authors: Felicia Chu
      Pages: 74 - 80
      Abstract: Felicia Chu
      Astrocyte 2018 5(1):74-80
      Numerous anti-epileptic drugs now exist worldwide for the treatment of epilepsy. With the availability of second- and third-generation antiepileptic medications, many factors may need to be considered in choosing the most appropriate treatment for an individual based on the tolerability, efficacy, and cost. This review highlights the treatment options and provides insights into how to choose among the various medications available.
      Citation: Astrocyte 2018 5(1):74-80
      PubDate: Mon,28 Jan 2019
      DOI: 10.4103/astrocyte.astrocyte_54_18
      Issue No: Vol. 5, No. 1 (2019)
       
  • Neuromuscular diseases: Recent advances in antisense oligonucleotide
           therapy

    • Authors: Ashok Verma
      Pages: 81 - 85
      Abstract: Ashok Verma
      Astrocyte 2018 5(1):81-85
      Genetic neuromuscular diseases are caused by defective expression of nuclear or mitochondrial genes. Toxic mutant protein may cause cell death, and thus, strategies that reduce mutant gene expression may provide therapeutic benefit. Synthetic antisense oligonucleotide (ASO) has been known to recognize cellular RNA and control gene expression. In recent years, advances in ASO chemistry, creation of designer ASO molecules to enhance their delivery and safety, and design of clinical trials to judge therapeutic efficacy have ushered into an era of plausible application of ASO technology to treat currently incurable neuromuscular diseases. The US Food and Drug Administration has recently approved two ASO therapies in genetic neuromuscular diseases. This brief overview examines the recent advances in ASO technology, evolution, and use of synthetic ASOs as therapeutic platform, and the mechanism of ASO action by exon-inclusion in spinal muscular atrophy and exon-skipping in Duchenne muscular dystrophy, with attention to their advantages and limitations.
      Citation: Astrocyte 2018 5(1):81-85
      PubDate: Mon,28 Jan 2019
      DOI: 10.4103/astrocyte.astrocyte_55_18
      Issue No: Vol. 5, No. 1 (2019)
       
 
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