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MEDICAL SCIENCES (2406 journals)            First | 1 2 3 4 5 6 7 8 | Last

Showing 401 - 600 of 3562 Journals sorted alphabetically
Ceylon Medical Journal     Open Access  
Chattagram Maa-O-Shishu Hospital Medical College Journal     Open Access  
Chiang Mai Medical Journal     Open Access  
ChiangRai Medical Journal     Open Access  
Chimerism     Full-text available via subscription  
Chinese Journal of Integrative Medicine     Hybrid Journal   (Followers: 3)
Chinese Journal of Natural Medicines     Full-text available via subscription   (Followers: 1)
Chinese Medical Journal     Open Access   (Followers: 10)
Chinese Medical Record English Edition     Hybrid Journal  
Chinese Medical Sciences Journal     Full-text available via subscription   (Followers: 2)
Chinese Medicine     Open Access   (Followers: 2)
Chinese Medicine     Open Access   (Followers: 4)
Chinesische Medizin / Chinese Medicine     Full-text available via subscription   (Followers: 2)
Chisholm Health Ethics Bulletin     Full-text available via subscription   (Followers: 1)
CHRISMED Journal of Health and Research     Open Access   (Followers: 2)
Christian Journal for Global Health     Open Access  
Chronic Diseases and Translational Medicine     Open Access  
Chronic Illness     Hybrid Journal   (Followers: 6)
Chronic Wound Care Management and Research     Open Access   (Followers: 6)
Chronobiology International     Hybrid Journal   (Followers: 3)
ChronoPhysiology and Therapy     Open Access  
Chulalongkorn Medical Bulletin     Open Access  
Chulalongkorn Medical Journal     Open Access  
Ciencia & Salud     Open Access   (Followers: 1)
Ciencia e Innovación en Salud     Open Access  
Ciencia e Investigación Medico Estudiantil Latinoamericana     Open Access  
Ciencia y Salud     Open Access   (Followers: 4)
Ciencias Clínicas     Open Access  
CienciaUAT     Open Access   (Followers: 1)
Cilia     Open Access  
Circulation : Arrhythmia and Electrophysiology     Hybrid Journal   (Followers: 10)
Cirugía Española     Full-text available via subscription   (Followers: 1)
Cirugía Paraguaya     Open Access  
Cleveland Clinic Journal of Medicine     Free   (Followers: 3)
Climacteric     Hybrid Journal   (Followers: 9)
Clin-Alert     Hybrid Journal   (Followers: 1)
Clínica     Open Access  
Clínica y Salud     Open Access  
Clinical Anatomy     Hybrid Journal   (Followers: 7)
Clinical and Experimental Health Sciences     Open Access   (Followers: 1)
Clinical and Molecular Hepatology     Open Access   (Followers: 2)
Clinical and Translational Medicine     Open Access   (Followers: 2)
Clinical Audit     Open Access   (Followers: 3)
Clinical Autonomic Research     Hybrid Journal   (Followers: 1)
Clinical Biochemist Reviews     Full-text available via subscription   (Followers: 1)
Clinical Biomechanics     Hybrid Journal   (Followers: 27)
Clinical Case Reports     Open Access   (Followers: 1)
Clinical Case Studies     Hybrid Journal   (Followers: 3)
Clinical Cornerstone     Full-text available via subscription  
Clinical Diabetology     Hybrid Journal  
Clinical Dysmorphology     Hybrid Journal   (Followers: 1)
Clinical eHealth     Open Access  
Clinical Infection in Practice     Open Access   (Followers: 1)
Clinical Interventions in Aging     Open Access   (Followers: 3)
Clinical Investigation     Full-text available via subscription   (Followers: 1)
Clinical Lipidology     Open Access   (Followers: 1)
Clinical Liver Disease     Open Access   (Followers: 5)
Clinical Medicine and Diagnostics     Open Access   (Followers: 3)
Clinical Medicine and Research     Open Access   (Followers: 6)
Clinical Medicine Insights : Case Reports     Open Access   (Followers: 1)
Clinical Medicine Insights : Therapeutics     Open Access   (Followers: 1)
Clinical Nutrition ESPEN     Hybrid Journal   (Followers: 18)
Clinical Obesity     Hybrid Journal   (Followers: 18)
Clinical Parkinsonism & Related Disorders     Open Access   (Followers: 1)
Clinical Phytoscience     Open Access  
Clinical Plasma Medicine     Hybrid Journal  
Clinical Practice     Open Access   (Followers: 1)
Clinical Reviews and Opinions     Open Access   (Followers: 1)
Clinical Sarcoma Research     Open Access  
Clinical Trials in Degenerative Diseases     Open Access  
Clinical Update     Full-text available via subscription  
ClinicoEconomics and Outcomes Research     Open Access   (Followers: 2)
Clinics     Open Access  
Clinics and Practice     Open Access  
Clinics in Chest Medicine     Full-text available via subscription   (Followers: 16)
Clinics in Laboratory Medicine     Full-text available via subscription   (Followers: 14)
Clocks & Sleep     Open Access   (Followers: 2)
CMAJ Open     Open Access   (Followers: 18)
CME     Hybrid Journal   (Followers: 2)
CNS Drug Reviews     Open Access   (Followers: 5)
CNS Drugs     Full-text available via subscription   (Followers: 8)
Cochrane Database of Systematic Reviews (Highlights)     Partially Free   (Followers: 21)
Cogent Medicine     Open Access  
Cold Spring Harbor Perspectives in Medicine     Full-text available via subscription   (Followers: 1)
Colombia Forense     Open Access  
Colombia Médica     Open Access   (Followers: 1)
Colorectal Cancer: Open Access     Open Access  
Coluna/Columna     Open Access  
Combination Products in Therapy     Open Access  
Community Based Medical Journal     Open Access  
Comparative Effectiveness Research     Open Access  
Comparative Medicine     Full-text available via subscription   (Followers: 6)
Complementary Medicine Research     Full-text available via subscription  
Comprehensive Series in Photosciences     Full-text available via subscription  
Comptes Rendus Geoscience     Full-text available via subscription   (Followers: 9)
Computational and Mathematical Methods in Medicine     Open Access   (Followers: 2)
Computational Brain & Behavior     Hybrid Journal  
Computers in Biology and Medicine     Hybrid Journal   (Followers: 10)
Conference Papers in Science     Open Access   (Followers: 2)
ConScientiae Saúde     Open Access  
Contemporary Clinical Trials     Hybrid Journal   (Followers: 10)
Contemporary Clinical Trials Communications     Open Access  
Contemporary Drug Problems     Full-text available via subscription   (Followers: 3)
Core Evidence     Open Access   (Followers: 1)
Correo Científico Médico     Open Access  
Cortex     Hybrid Journal   (Followers: 22)
CRANIO® : The Journal of Craniomandibular & Sleep Practice     Hybrid Journal   (Followers: 3)
CRISPR Journal     Hybrid Journal  
Critical Ultrasound Journal     Open Access   (Followers: 4)
Cuadernos de Bioetica     Open Access   (Followers: 1)
Cukurova Medical Journal     Open Access   (Followers: 2)
Cumhuriyet Medical Journal     Open Access  
Curare     Open Access  
Current Aging Science     Hybrid Journal   (Followers: 2)
Current Attention Disorders Reports     Hybrid Journal   (Followers: 1)
Current Biomarker Findings     Open Access   (Followers: 1)
Current Clinical Microbiology Reports     Hybrid Journal   (Followers: 4)
Current Developmental Disorders Reports     Hybrid Journal   (Followers: 3)
Current Directions in Biomedical Engineering     Open Access  
Current GERD Reports     Hybrid Journal  
Current Issues in Pharmacy and Medical Sciences     Open Access   (Followers: 5)
Current Medical Issues     Open Access   (Followers: 2)
Current Medical Research and Opinion     Hybrid Journal   (Followers: 19)
Current Medical Science     Hybrid Journal   (Followers: 4)
Current Nanomedicine     Hybrid Journal   (Followers: 1)
Current Opinion in Molecular Therapeutics     Full-text available via subscription   (Followers: 13)
Current Pathobiology Reports     Hybrid Journal  
Current Regenerative Medicine     Hybrid Journal   (Followers: 1)
Current Research : Concussion     Open Access  
Current Research in Medicine     Open Access   (Followers: 3)
Current Signal Transduction Therapy     Hybrid Journal  
Current Tissue Engineering     Hybrid Journal   (Followers: 4)
Current Topics in Medicinal Chemistry     Hybrid Journal   (Followers: 9)
Current Topics in Microbiology and Immunology     Hybrid Journal   (Followers: 15)
Current Traditional Medicine     Hybrid Journal   (Followers: 4)
Current Transplantation Reports     Hybrid Journal   (Followers: 1)
Current Trauma Reports     Hybrid Journal   (Followers: 2)
Current Tropical Medicine Reports     Hybrid Journal  
CVD Prevention and Control     Hybrid Journal  
CytoJournal     Open Access   (Followers: 3)
Cytokine     Hybrid Journal   (Followers: 6)
Cytokine : X     Open Access  
Dados - Revista de Ciências Sociais     Open Access  
Dalhousie Medical Journal     Open Access  
Danish Medical Journal     Partially Free   (Followers: 7)
Dar Es Salaam Medical Students' Journal     Open Access  
Das Gesundheitswesen     Hybrid Journal   (Followers: 10)
Decision Sciences Journal of Innovative Education     Hybrid Journal   (Followers: 5)
Delta Medical College Journal     Open Access   (Followers: 1)
Denkbeeld     Hybrid Journal  
Dentistry and Medical Research     Open Access   (Followers: 1)
Der Freie Zahnarzt     Hybrid Journal  
Der Gynakologe     Hybrid Journal   (Followers: 2)
Der Klinikarzt     Hybrid Journal  
Der Notarzt     Hybrid Journal   (Followers: 3)
Der Nuklearmediziner     Hybrid Journal  
Deutsche Zeitschrift für Akupunktur     Full-text available via subscription   (Followers: 2)
Developments in Volcanology     Full-text available via subscription   (Followers: 3)
Diabetology International     Hybrid Journal   (Followers: 5)
Diagnostic and Interventional Imaging     Full-text available via subscription  
Diagnostic and Prognostic Research     Open Access  
Diagnostics     Open Access   (Followers: 1)
Diálisis y Trasplante     Full-text available via subscription  
Dialogues in Clinical Neuroscience & Mental Health     Open Access  
Dialyse aktuell     Hybrid Journal   (Followers: 1)
Dicle Tıp Dergisi / Dicle Medical Journal     Open Access  
Die Hebamme     Hybrid Journal  
Digital Chinese Medicine     Open Access   (Followers: 1)
Digital Medicine     Open Access  
Directieve therapie     Hybrid Journal  
Disability, CBR & Inclusive Development     Open Access   (Followers: 17)
Disaster and Military Medicine     Open Access   (Followers: 5)
Discussion of Clinical Cases     Open Access   (Followers: 1)
Disease Control Journal     Open Access  
Disease Markers     Open Access   (Followers: 1)
Disease Models and Mechanisms     Open Access   (Followers: 1)
Diseases     Open Access  
Diversity of Research in Health Journal     Open Access  
DMW - Deutsche Medizinische Wochenschrift     Hybrid Journal   (Followers: 40)
DNA and RNA Nanotechnology     Open Access  
DoctorConsult - The Journal. Wissen für Klinik und Praxis     Full-text available via subscription  
Doklady Biological Sciences     Hybrid Journal  
Doklady Earth Sciences     Hybrid Journal   (Followers: 2)
Dokuz Eylül Üniversitesi Tıp Fakültesi Dergisi     Open Access  
Dor on line     Open Access   (Followers: 1)
Douleurs : Evaluation - Diagnostic - Traitement     Full-text available via subscription  
Drug and Therapeutics Bulletin     Hybrid Journal   (Followers: 9)
Drug Delivery and Translational Research     Hybrid Journal   (Followers: 2)
Drug Development and Therapeutics     Open Access  
Drug Resistance Updates     Hybrid Journal   (Followers: 3)
Duazary     Open Access   (Followers: 1)
Dubai Medical Journal     Open Access  
Düzce Tıp Fakültesi Dergisi / Duzce Medical Journal     Open Access  
Düzce Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi / Journal of Duzce University Health Sciences Institute     Open Access  
Dynamis : Acta Hispanica ad Medicinae Scientiarumque Historiam Illustrandam     Open Access   (Followers: 3)
E-Jurnal Medika Udayana     Open Access   (Followers: 2)
Early Science and Medicine     Hybrid Journal   (Followers: 6)
East African Journal of Public Health     Full-text available via subscription   (Followers: 4)
East African Medical Journal     Full-text available via subscription   (Followers: 2)
Eating and Weight Disorders - Studies on Anorexia, Bulimia and Obesity     Hybrid Journal   (Followers: 24)

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Journal Cover
Chinese Journal of Natural Medicines
Number of Followers: 1  
 
  Full-text available via subscription Subscription journal
ISSN (Print) 1875-5364
Published by Elsevier Homepage  [3203 journals]
  • Quantification of Panax notoginseng saponins metabolites in rat plasma
           with in vivo gut microbiota-mediated biotransformation by HPLC-MS/MS
    • Abstract: Publication date: March 2019Source: Chinese Journal of Natural Medicines, Volume 17, Issue 3Author(s): Yin-Ping GUO, Man-Yun CHEN, Li SHAO, Wei ZHANG, Tai RAO, Hong-Hao ZHOU, Wei-Hua HUANGAbstractPanax notoginseng saponins (PNS) are the major components of Panax notoginseng, with multiple pharmacological activities but poor oral bioavailability. PNS could be metabolized by gut microbiota in vitro, while the exact role of gut microbiota of PNS metabolism in vivo remains poorly understood. In this study, pseudo germ-free rat models were constructed by using broad-spectrum antibiotics to validate the gut microbiota-mediated transformation of PNS in vivo. Moreover, a high performance liquid chromatography-electrospray ionization tandem mass spectrometry (HPLC-ESI-MS/MS) was developed for quantitative analysis of four metabolites of PNS, including ginsenoside F1 (GF1), ginsenoside Rh2 (GRh2), ginsenoside compound K (GCK) and protopanaxatriol (PPT). The results showed that the four metabolites could be detected in the control rat plasma, while they could not be determined in pseudo germ-free rat plasma. The results implied that PNS could not be biotransformed effectively when gut microbiota was disrupted. In conclusion, gut microbiota plays an important role in biotransformation of PNS into metabolites in vivo.
       
  • Two new nimbolinin- and trichilin-class limonoids isolated from the fruits
           of Melia azedarach
    • Abstract: Publication date: March 2019Source: Chinese Journal of Natural Medicines, Volume 17, Issue 3Author(s): Lu QIU, Li HENG, Rong XU, Jun LUO, Yi LIAbstractTwo new furan fragment isomerized limonoids, meliazedalides A and B (compounds 1 and 2), were isolated from the fruits of Melia azedarach Linn.. Their chemical structures were elucidated on the basis of HR-ESI-MS and 1D and 2D NMR data, which belonged to nimbolinin- and trichilin-class, respectively. Compound 2 exhibited weak inhibitory effect on NO production in lipopolysaccharide (LPS)-activated RAW 264.7 macrophages with IC50 being 37.41 μmol·L−1.
       
  • Lower clearance of sodium tanshinone IIA sulfonate in coronary heart
           disease patients and the effect of total bilirubin: a population
           pharmacokinetics analysis
    • Abstract: Publication date: March 2019Source: Chinese Journal of Natural Medicines, Volume 17, Issue 3Author(s): Wei-Wei QIN, Li WANG, Zheng JIAO, Bin WANG, Cheng-Yu WANG, Li-Xuan QIAN, Wei-Lin QI, Ming-Kang ZHONGAbstractThis study developed a population pharmacokinetic model for sodium tanshinone IIA sulfonate (STS) in healthy volunteers and coronary heart disease (CHD) patients in order to identify significant covariates for the pharmacokinetics of STS. Blood samples were obtained by intense sampling approach from 10 healthy volunteers and sparse sampling from 25 CHD patients, and a population pharmacokinetic analysis was performed by nonlinear mixed-effect modeling. The final model was evaluated by bootstrap and visual predictive check. A total of 230 plasma concentrations were included, 137 from healthy volunteers and 93 from CHD patients. It was a two-compartment model with first-order elimination. The typical value of the apparent clearance (CL) of STS in CHD patients with total bilirubin (TBIL) level of 10 μmol(L−1 was 48.7 L(h−1 with inter individual variability of 27.4%, whereas that in healthy volunteers with the same TBIL level was 63.1 L(h−1. Residual variability was described by a proportional error model and estimated at 5.2%. The CL of STS in CHD patients was lower than that in healthy volunteers and decreased when TBIL levels increased. The bootstrap and visual predictive check confirmed the stability and validity of the final model. These results suggested that STS dosage adjustment might be considered based on TBIL levels in CHD patients.
       
  • Two natural molecules preferentially inhibit azole-resistant Candida
           albicans with MDR1 hyperactivation
    • Abstract: Publication date: March 2019Source: Chinese Journal of Natural Medicines, Volume 17, Issue 3Author(s): Hong-Zhuo SHI, Wen-Qiang CHANG, Ming ZHANG, Hong-Xiang LOUAbstractAntifungal drug resistance is a significant clinical problem, and antifungal agents that can evade resistance are urgently needed. In infective niches, resistant organisms often co-existed with sensitive ones, or a subpopulation of antibiotic-susceptible organisms may evolve into resistant ones during antibiotic treatment and eventually dominate the whole population. In this study, we established a co-culture assay in which an azole-resistant Candida albicans strain was mixed with a susceptible strain labeled with green fluorescent protein to mimic in vivo conditions and screen for antifungal drugs. Fluconazole was used as a positive control to verify the validity of this co-culture assay. Five natural molecules exhibited antifungal activity against both susceptible and resistant C. albicans. Two of these compounds, retigeric acid B (RAB) and riccardin D (RD), preferentially inhibited C. albicans strains in which the efflux pump MDR1 was activated. This selectivity was attributed to greater intracellular accumulation of the drugs in the resistant strains. Changes in sterol and lipid compositions were observed in the resistant strains compared to the susceptible strain, and might increase cell permeability to RAB and RD. In addition, RAB and RD interfered with the sterol pathway, further aggregating the decrease in ergosterol in the sterol synthesis pathway in the MDR1-activated strains. Our findings here provide an alternative for combating resistant pathogenic fungi.
       
  • The Zuo Jin Wan Formula increases chemosensitivity of human primary
           gastric cancer cells by AKT mediated mitochondrial translocation of
           cofilin-1
    • Abstract: Publication date: March 2019Source: Chinese Journal of Natural Medicines, Volume 17, Issue 3Author(s): Meng-Yao SUN, Dan-Dan WANG, Jian SUN, Xiao-Hua ZHAO, Si CAI, Qiu-Xue WU, Tao JIE, Zhen-Hua NI, Jian-Yue SUN, Qing-Feng TANGAbstractResistance to cisplatin (DDP)-based chemotherapy is a major cause of treatment failure in human gastric cancer (GC). It is necessary to identify the drugs to re-sensitize GC cells to DDP. In our previous research, Zuo Jin Wan Formula (ZJW) has been proved could increase the mitochondrial apoptosis via cofilin-1 in a immortalized cell line, SGC-7901/DDP. Due to the immortalized cells may still difficult highly recapitulate the important molecular events in vivo, primary GC cells model derived from clinical patient was constructed in the present study to further evaluate the effect of ZJW and the underlying molecular mechanism. Immunofluorescent staining was used to indentify primary cultured human GC cells. Western blotting was carried out to detect the protein expression. Cell Counting Kit-8 (CCK-8) was used to evaluate cell proliferation. Flow cytometry analysis was performed to assess cell apoptosis. ZJW inhibited proliferation and induced apoptosis in primary DDP-resistant GC cells. Notably, the apoptosis in GC cells was mediated by inducing cofilin-1 mitochondrial translocation, down-regulating Bcl-2 and up-regulating Bax expression. Surprisingly, the level of p-AKT protein was higher in DDP-resistant GC cells than that of the DDP-sensitive GC cells, and the activation of AKT could attenuate ZJW-induced sensitivity to DDP. These data revealed that ZJW can increase the chemosensitivity in DDP-resistant primary GC cells by inducing mitochondrial apoptosis and AKT inactivation. The combining chemotherapy with ZJW may be an effective therapeutic strategy for GC chemoresistance patients.
       
  • Houttuynia cordata polysaccharide alleviated intestinal injury and
           modulated intestinal microbiota in H1N1 virus infected mice
    • Abstract: Publication date: March 2019Source: Chinese Journal of Natural Medicines, Volume 17, Issue 3Author(s): Mei-Yu CHEN, Hong LI, Xiao-Xiao LU, Li-Jun LING, Hong-Bo WENG, Wei SUN, Dao-Feng CHEN, Yun-Yi ZHANGAbstractHouttuynia cordata polysaccharide (HCP) is extracted from Houttuynia cordata, a key traditional Chinese medicine. The study was to investigate the effects of HCP on intestinal barrier and microbiota in H1N1 virus infected mice. Mice were infected with H1N1 virus and orally administrated HCP at a dosage of 40 mg(kg−1(d−1. H1N1 infection caused pulmonary and intestinal injury and gut microbiota imbalance. HCP significantly suppressed the expression of hypoxia inducible factor-1α and decreased mucosubstances in goblet cells, but restored the level of zonula occludens-1 in intestine. HCP also reversed the composition change of intestinal microbiota caused by H1N1 infection, with significantly reduced relative abundances of Vibrio and Bacillus, the pathogenic bacterial genera. Furthermore, HCP rebalanced the gut microbiota and restored the intestinal homeostasis to some degree. The inhibition of inflammation was associated with the reduced level of Toll-like receptors and interleukin-1β in intestine, as well as the increased production of interleukin-10. Oral administration of HCP alleviated lung injury and intestinal dysfunction caused by H1N1 infection. HCP may gain systemic treatment by local acting on intestine and microbiota. This study proved the high-value application of HCP.
       
  • Non-volatile constituents and pharmacology of Chimonanthus: A
           review
    • Abstract: Publication date: March 2019Source: Chinese Journal of Natural Medicines, Volume 17, Issue 3Author(s): Ren-Geng SHU, Yi-Li WAN, Xiao-Min WANGAbstractChimonanthus plants widely distributed in southern area of China, which have a long history of edibles and medicine. Phytochemical investigations have shown that Chimonanthus produced 143 non-volatile constituents, including alkaloids, flavonoids, terpenoids, coumarins and others, which exhibit significant anti-oxidant, anti-bacterial, anti-cancer, anti-inflammatory, antihyperglycemic, antihyperlipidemic and other biological activities. On the basis of systematic reviewing of literatures, this article overviews the non-volatile constituents and pharmacology of Chimonanthus from domestic and foreign over the last 30 years (until June 2018), and may provide a useful reference for the further development of Chimonanthus.
       
  • Romipeptides A and B, two new romidepsin derivatives isolated from
           Chromobacterium violaceum No.968 and their antitumor activities in vitro
    • Abstract: Publication date: February 2019Source: Chinese Journal of Natural Medicines, Volume 17, Issue 2Author(s): Lei XIONG, Chang-Fa CHEN, Tao-Ling MIN, Hai-Feng HUAbstractRomipeptides A and B (1 and 2), two new romidepsin derivatives, and three known compounds, chromopeptide A (3), romidepsin (4) and valine-leucine dipeptide (5) were isolated from the fermentation broth of Chromobacterium violaceum No. 968. Their structures were elucidated by interpretation of their UV, HR-ESI-MS and NMR spectra. The absolute configuration of compound 1 and 2 were established by single crystal X-ray diffraction analysis. Compounds 1–5 were evaluated for their anti-proliferative activities against three human cancer cell lines, SW620, HL60, and A549. The results showed most of these compounds exhibited antitumor activities in vitro, in which compound 2 displayed potent cytotoxicity to SW620, HL60 and A549 cell lines, with IC50 of 12.5, 6.7 and 5.7 nmol·L−1, respectively.
       
  • Peptides and polyketides isolated from the marine sponge-derived fungus
           Aspergillus terreus SCSIO 41008
    • Abstract: Publication date: February 2019Source: Chinese Journal of Natural Medicines, Volume 17, Issue 2Author(s): Xiao-Wei LUO, Yun LIN, Yong-Jun LU, Xue-Feng ZHOU, Yong-Hong LIUAbstractTwo new isomeric modified tripeptides, aspergillamides C and D (compounds 1 and 2), together with fifteen known compounds (compounds 3–17), were obtained from the marine sponge-derived fungus Aspergillus terreus SCSIO 41008. The structures of the new compounds, including absolute configurations, were determined by extensive analyses of spectroscopic data (NMR, MS, UV, and IR) and comparisons between the calculated and experimental electronic circular dichroism (ECD) spectra. Butyrolactone I (compound 11) exhibited strong inhibitory effects against Mycobacterium tuberculosis protein tyrosine phosphatase B (MptpB) with the IC50 being 5.11 ± 0.53 μmol·L−1, and acted as a noncompetitive inhibitor based on kinetic analysis.
       
  • Two symmetrical unsaturated acids isolated from Viscum album
    • Abstract: Publication date: February 2019Source: Chinese Journal of Natural Medicines, Volume 17, Issue 2Author(s): Duo CAO, Li-Qing WANG, Xiao-Min HAN, Hui-Rui GUAN, Meng LEI, Ya-Hui WEI, Liang CHENG, Pei-Ming YANG, Zheng-Liang SUN, Wen GAO, Jia-Kun DAIAbstractIn the present study, two new acetylene conjugate compounds, dibutyl (2Z, 6Z)-octa-2, 6-dien-4-yne dioate (1), and dibutyl (2E, 6E)- octa-2, 6-dien-4-yne dioate (2), were isolated from the dry stem leaves of Viscum album, along with nine known compounds (3 – 11). Their structures were confirmed on the basis of spectroscopic data. Compounds 1 and 8 showed antioxidant activity against xanthine oxidase (XOD) and 1,1-diphenyl-2-picrylhydrazyl radical 2,2-diphenyl-1-(2,4,6-trinitrophenyl) hydroxyl (DPPH), with the IC50 of 1.22 and 1.33 μmol·L−1, and the SC50 of 4.34 and 8.22 μmol·L−1, respectively.
       
  • Transcriptomic analysis in Anemone flaccida rhizomes reveals ancillary
           pathway for triterpene saponins biosynthesis and differential
           responsiveness to phytohormones
    • Abstract: Publication date: February 2019Source: Chinese Journal of Natural Medicines, Volume 17, Issue 2Author(s): Guo-Yan MO, Fang HUANG, Yin FANG, Lin-Tao HAN, Kayla K. Pennerman, Li-Jing BU, Xiao-Wei DU, Joan W. Bennett, Guo-Hua YINAbstractAnemone flaccida Fr. Schmidt is a perennial medicinal herb that contains pentacyclic triterpenoid saponins as the major bioactive constituents. In China, the rhizomes are used as treatments for a variety of ailments including arthritis. However, yields of the saponins are low, and little is known about the plant's genetic background or phytohormonal responsiveness. Using one-quarter of the 454 pyrosequencing information from the Roche GS FLX Titanium platform, we performed a transcriptomic analysis to identify 157 genes putatively encoding 26 enzymes involved in the synthesis of the bioactive compounds. It was revealed that there are two biosynthetic pathways of triterpene saponins in A. flaccida. One pathway depends on β-amyrin synthase and is similar to that found in other plants. The second, subsidiary (“backburner”) pathway is catalyzed by camelliol C synthase and yields β-amyrin as minor byproduct. Both pathways used cytochrome P450-dependent monooxygenases (CYPs) and family 1 uridine diphosphate glycosyltransferases (UGTs) to modify the triterpenoid backbone. The expression of CYPs and UGTs were quite different in roots treated with the phytohormones methyl jasmonate, salicylic acid and indole-3-acetic acid. This study provides the first large-scale transcriptional dataset for the biosynthetic pathways of triterpene saponins and their phytohormonal responsiveness in the genus Anemone.
       
  • Hesperetin derivative-12 (HDND-12) regulates macrophage polarization by
           modulating JAK2/STAT3 signaling pathway
    • Abstract: Publication date: February 2019Source: Chinese Journal of Natural Medicines, Volume 17, Issue 2Author(s): Ling-Na KONG, Xiang LIN, Cheng HUANG, Tao-Tao MA, Xiao-Ming MENG, Chao-Jie HU, Qian-Qian WANG, Yan-Hui LIU, Qing-Ping SHI, Jun LIAbstractMacrophages show significant heterogeneity in function and phenotype, which could shift into different populations of cells in response to exposure to various micro-environmental signals. These changes, also termed as macrophage polarization, of which play an important role in the pathogenesis of many diseases. Numerous studies have proved that Hesperidin (HDN), a traditional Chinese medicine, extracted from fruit peels of the genus citrus, play key roles in anti-inflammation, anti-tumor, anti-oxidant and so on. However, the role of HDN in macrophage polarization has never been reported. Additional, because of its poor water solubility and bioavailability. Our laboratory had synthesized many hesperidin derivatives. Among them, hesperidin derivatives-12 (HDND-12) has better water solubility and bioavailability. So, we evaluated the role of HDND-12 in macrophage polarization in the present study. The results showed that the expression of Arginase-1 (Arg-1), interleukin-10 (IL-10), transforming growth factor β (TGF-β) were up-regulated by HDND-12, whereas the expression of inducible Nitric Oxide Synthase (iNOS) was down-regulated in LPS- and IFN-γ-treated (M1) RAW264.7 cells. Moreover, the expression of p-JAK2 and p-STAT3 were significantly decreased after stimulation with HDND-12 in M1-like macrophages. More importantly, when we taken AG490 (inhibitor of JAK2/STAT3 signaling), the protein levels of iNOS were significantly reduced in AG490 stimulation group compare with control in LPS, IFN-γ and HDND-12 stimulation cells. Taken together, these findings indicated that HDND-12 could prevent polarization toward M1-like macrophages, at least in part, through modulating JAK2/STAT3 pathway.
       
  • Characteristics of the traditional Liu-Wei-Di-Huang prescription
           reassessed in modern pharmacology
    • Abstract: Publication date: February 2019Source: Chinese Journal of Natural Medicines, Volume 17, Issue 2Author(s): Xiao-Rui CHENG, Chun-Hui QI, Tong-Xing WANG, Wen-Xia ZHOU, Yong-Xiang ZHANGAbstractLiu-Wei-Di-Huang (LW) is a Yin nourishing and kidney tonifying prescription in traditional Chinese medicine with promising pharmacological characteristics that can be further exploited and developed in modern medicine. We provide a comprehensive and detailed literature report on the clinical and experimental pharmacology of LW, including its quality control parameters, phytochemistry, pharmacokinetics, and toxicology. Our literature review indicates that the LW prescription possesses a unique combination of pharmacological characteristics that can be safely used for treating very different diseases. Quality control and pharmacokinetic parameters of LW are mostly based on its major bioactive phytochemical constituents. We postulate that modulating or rebalancing the neuroendocrine immunomodulation network in the body is the underlying mechanism of the multiple pharmacological activities displayed by LW.
       
  • Progress in active compounds effective on ulcerative colitis from Chinese
           medicines
    • Abstract: Publication date: February 2019Source: Chinese Journal of Natural Medicines, Volume 17, Issue 2Author(s): Si-Yu CAO, Sheng-Jie YE, Wei-Wei WANG, Bing WANG, Tong ZHANG, Yi-Qiong PUAbstractUlcerative colitis (UC), a chronic inflammatory disease affecting the colon, has a rising incidence worldwide. The known pathogenesis is multifactorial and involves genetic predisposition, epithelial barrier defects, dysregulated immune responses, and environmental factors. Nowadays, the drugs for UC include 5-aminosalicylic acid, steroids, and immunosuppressants. Long-term use of these drugs, however, may cause several side effects, such as hepatic and renal toxicity, drug resistance and allergic reactions. Moreover, the use of traditional Chinese medicine (TCM) in the treatment of UC shows significantly positive effects, low recurrence rate, few side effects and other obvious advantages. This paper summarizes several kinds of active compounds used in the experimental research of anti-UC effects extracted from TCM, mainly including flavonoids, acids, terpenoids, phenols, alkaloids, quinones, and bile acids from some animal medicines. It is found that the anti-UC activities are mainly focused on targeting inflammation or oxidative stress, which is associated with increasing the levels of anti-inflammatory cytokine (IL-4, IL-10, SOD), suppressing the levels of pro-inflammatory cytokines (TNF-α, IL-1β, IL-6, IL-8, IL-23, NF-κB, NO), reducing the activity of MPO, MDA, IFN-γ, and iNOS. This review may offer valuable reference for UC-related studies on the compounds from natural medicines.
       
 
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