Publisher: Sage Publications   (Total: 1166 journals)

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Showing 1 - 200 of 1166 Journals sorted alphabetically
AADE in Practice     Hybrid Journal   (Followers: 6)
Abstracts in Anthropology     Full-text available via subscription   (Followers: 29)
Academic Pathology     Open Access   (Followers: 6)
Accounting History     Hybrid Journal   (Followers: 18, SJR: 0.527, CiteScore: 1)
Acta Radiologica     Hybrid Journal   (Followers: 1, SJR: 0.754, CiteScore: 2)
Acta Radiologica Open     Open Access   (Followers: 2)
Acta Sociologica     Hybrid Journal   (Followers: 39, SJR: 0.939, CiteScore: 2)
Action Research     Hybrid Journal   (Followers: 53, SJR: 0.308, CiteScore: 1)
Active Learning in Higher Education     Hybrid Journal   (Followers: 398, SJR: 1.397, CiteScore: 2)
Adaptive Behavior     Hybrid Journal   (Followers: 9, SJR: 0.288, CiteScore: 1)
Administration & Society     Hybrid Journal   (Followers: 18, SJR: 0.675, CiteScore: 1)
Adoption & Fostering     Hybrid Journal   (Followers: 25, SJR: 0.313, CiteScore: 0)
Adsorption Science & Technology     Open Access   (Followers: 9, SJR: 0.258, CiteScore: 1)
Adult Education Quarterly     Hybrid Journal   (Followers: 262, SJR: 0.566, CiteScore: 2)
Adult Learning     Hybrid Journal   (Followers: 51)
Advances in Dental Research     Hybrid Journal   (Followers: 11, SJR: 1.791, CiteScore: 4)
Advances in Developing Human Resources     Hybrid Journal   (Followers: 35, SJR: 0.614, CiteScore: 2)
Advances in Mechanical Engineering     Open Access   (Followers: 156, SJR: 0.272, CiteScore: 1)
Advances in Methods and Practices in Psychological Science     Full-text available via subscription   (Followers: 20)
Advances in Structural Engineering     Full-text available via subscription   (Followers: 51, SJR: 0.599, CiteScore: 1)
AERA Open     Open Access   (Followers: 14)
Affilia     Hybrid Journal   (Followers: 6, SJR: 0.496, CiteScore: 1)
Africa Spectrum     Open Access   (Followers: 17)
Agrarian South : J. of Political Economy     Hybrid Journal   (Followers: 3)
Air, Soil & Water Research     Open Access   (Followers: 13, SJR: 0.214, CiteScore: 1)
Alexandria : The J. of National and Intl. Library and Information Issues     Full-text available via subscription   (Followers: 68)
Allergy & Rhinology     Open Access   (Followers: 5)
AlterNative : An Intl. J. of Indigenous Peoples     Full-text available via subscription   (Followers: 39, SJR: 0.194, CiteScore: 0)
Alternative Law J.     Hybrid Journal   (Followers: 12, SJR: 0.176, CiteScore: 0)
Alternatives : Global, Local, Political     Hybrid Journal   (Followers: 12, SJR: 0.351, CiteScore: 1)
Alternatives to Laboratory Animals     Full-text available via subscription   (Followers: 11, SJR: 0.297, CiteScore: 1)
American Behavioral Scientist     Hybrid Journal   (Followers: 26, SJR: 0.982, CiteScore: 2)
American Economist     Hybrid Journal   (Followers: 7)
American Educational Research J.     Hybrid Journal   (Followers: 260, SJR: 2.913, CiteScore: 3)
American J. of Alzheimer's Disease and Other Dementias     Hybrid Journal   (Followers: 23, SJR: 0.67, CiteScore: 2)
American J. of Cosmetic Surgery     Hybrid Journal   (Followers: 9)
American J. of Evaluation     Hybrid Journal   (Followers: 18, SJR: 0.646, CiteScore: 2)
American J. of Health Promotion     Hybrid Journal   (Followers: 35, SJR: 0.807, CiteScore: 1)
American J. of Hospice and Palliative Medicine     Hybrid Journal   (Followers: 47, SJR: 0.65, CiteScore: 1)
American J. of Law & Medicine     Full-text available via subscription   (Followers: 12, SJR: 0.204, CiteScore: 1)
American J. of Lifestyle Medicine     Hybrid Journal   (Followers: 7, SJR: 0.431, CiteScore: 1)
American J. of Medical Quality     Hybrid Journal   (Followers: 13, SJR: 0.777, CiteScore: 1)
American J. of Men's Health     Open Access   (Followers: 9, SJR: 0.595, CiteScore: 2)
American J. of Rhinology and Allergy     Hybrid Journal   (Followers: 11, SJR: 0.972, CiteScore: 2)
American J. of Sports Medicine     Hybrid Journal   (Followers: 249, SJR: 3.949, CiteScore: 6)
American Politics Research     Hybrid Journal   (Followers: 36, SJR: 1.313, CiteScore: 1)
American Review of Public Administration     Hybrid Journal   (Followers: 28, SJR: 2.062, CiteScore: 2)
American Sociological Review     Hybrid Journal   (Followers: 358, SJR: 6.333, CiteScore: 6)
American String Teacher     Full-text available via subscription   (Followers: 3)
Analytical Chemistry Insights     Open Access   (Followers: 26, SJR: 0.224, CiteScore: 1)
Angiology     Hybrid Journal   (Followers: 5, SJR: 0.849, CiteScore: 2)
Animation     Hybrid Journal   (Followers: 15, SJR: 0.197, CiteScore: 0)
Annals of Clinical Biochemistry     Hybrid Journal   (Followers: 10, SJR: 0.634, CiteScore: 1)
Annals of Otology, Rhinology & Laryngology     Hybrid Journal   (Followers: 20, SJR: 0.807, CiteScore: 1)
Annals of Pharmacotherapy     Hybrid Journal   (Followers: 59, SJR: 1.096, CiteScore: 2)
Annals of the American Academy of Political and Social Science     Hybrid Journal   (Followers: 51, SJR: 1.225, CiteScore: 3)
Annals of the ICRP     Hybrid Journal   (Followers: 4, SJR: 0.548, CiteScore: 1)
Anthropocene Review     Hybrid Journal   (Followers: 8, SJR: 3.341, CiteScore: 7)
Anthropological Theory     Hybrid Journal   (Followers: 48, SJR: 0.739, CiteScore: 1)
Antitrust Bulletin     Hybrid Journal   (Followers: 14)
Antiviral Chemistry and Chemotherapy     Open Access   (Followers: 2, SJR: 0.635, CiteScore: 2)
Antyajaa : Indian J. of Women and Social Change     Hybrid Journal   (Followers: 1)
Applied Biosafety     Hybrid Journal   (Followers: 1, SJR: 0.131, CiteScore: 0)
Applied Psychological Measurement     Hybrid Journal   (Followers: 21, SJR: 1.17, CiteScore: 1)
Applied Spectroscopy     Full-text available via subscription   (Followers: 27, SJR: 0.489, CiteScore: 2)
Armed Forces & Society     Hybrid Journal   (Followers: 25, SJR: 0.29, CiteScore: 1)
Arthaniti : J. of Economic Theory and Practice     Full-text available via subscription  
Arts and Humanities in Higher Education     Hybrid Journal   (Followers: 49, SJR: 0.305, CiteScore: 1)
Asia Pacific Media Educator     Hybrid Journal   (Followers: 1, SJR: 0.23, CiteScore: 0)
Asia-Pacific J. of Management Research and Innovation     Full-text available via subscription   (Followers: 3)
Asia-Pacific J. of Public Health     Hybrid Journal   (Followers: 15, SJR: 0.558, CiteScore: 1)
Asia-Pacific J. of Rural Development     Hybrid Journal   (Followers: 2)
Asian and Pacific Migration J.     Full-text available via subscription   (Followers: 8, SJR: 0.324, CiteScore: 1)
Asian Cardiovascular and Thoracic Annals     Hybrid Journal   (Followers: 2, SJR: 0.305, CiteScore: 0)
Asian J. of Comparative Politics     Hybrid Journal   (Followers: 5)
Asian J. of Legal Education     Full-text available via subscription   (Followers: 4)
Asian J. of Management Cases     Hybrid Journal   (Followers: 6, SJR: 0.101, CiteScore: 0)
ASN Neuro     Open Access   (Followers: 2, SJR: 1.534, CiteScore: 3)
Assessment     Hybrid Journal   (Followers: 19, SJR: 1.519, CiteScore: 3)
Assessment for Effective Intervention     Hybrid Journal   (Followers: 15, SJR: 0.578, CiteScore: 1)
Australasian J. of Early Childhood     Hybrid Journal   (Followers: 7, SJR: 0.535, CiteScore: 1)
Australasian Psychiatry     Hybrid Journal   (Followers: 18, SJR: 0.433, CiteScore: 1)
Australian & New Zealand J. of Psychiatry     Hybrid Journal   (Followers: 30, SJR: 1.801, CiteScore: 2)
Australian and New Zealand J. of Criminology     Hybrid Journal   (Followers: 547, SJR: 0.612, CiteScore: 1)
Australian J. of Career Development     Hybrid Journal   (Followers: 5)
Australian J. of Education     Hybrid Journal   (Followers: 51, SJR: 0.403, CiteScore: 1)
Australian J. of Management     Hybrid Journal   (Followers: 13, SJR: 0.497, CiteScore: 1)
Autism     Hybrid Journal   (Followers: 358, SJR: 1.739, CiteScore: 4)
Autism & Developmental Language Impairments     Open Access   (Followers: 17)
Avian Biology Research     Hybrid Journal   (Followers: 6, SJR: 0.401, CiteScore: 1)
Behavior Modification     Hybrid Journal   (Followers: 14, SJR: 0.877, CiteScore: 2)
Behavioral and Cognitive Neuroscience Reviews     Hybrid Journal   (Followers: 27)
Behavioral Disorders     Hybrid Journal   (Followers: 2)
Beyond Behavior     Hybrid Journal   (Followers: 2)
Bible Translator     Hybrid Journal   (Followers: 13)
Biblical Theology Bulletin     Hybrid Journal   (Followers: 24, SJR: 0.184, CiteScore: 0)
Big Data & Society     Open Access   (Followers: 55)
Biochemistry Insights     Open Access   (Followers: 7)
Bioinformatics and Biology Insights     Open Access   (Followers: 12, SJR: 1.141, CiteScore: 2)
Biological Research for Nursing     Hybrid Journal   (Followers: 7, SJR: 0.685, CiteScore: 2)
Biomarker Insights     Open Access   (Followers: 1, SJR: 0.81, CiteScore: 2)
Biomarkers in Cancer     Open Access   (Followers: 11)
Biomedical Engineering and Computational Biology     Open Access   (Followers: 14)
Biomedical Informatics Insights     Open Access   (Followers: 8)
Bioscope: South Asian Screen Studies     Hybrid Journal   (Followers: 4, SJR: 0.235, CiteScore: 0)
BMS: Bulletin of Sociological Methodology/Bulletin de Méthodologie Sociologique     Hybrid Journal   (Followers: 4, SJR: 0.226, CiteScore: 0)
Body & Society     Hybrid Journal   (Followers: 29, SJR: 1.531, CiteScore: 3)
Bone and Tissue Regeneration Insights     Open Access   (Followers: 2)
Brain and Neuroscience Advances     Open Access  
Brain Science Advances     Open Access  
Breast Cancer : Basic and Clinical Research     Open Access   (Followers: 12, SJR: 0.823, CiteScore: 2)
British J. of Music Therapy     Hybrid Journal   (Followers: 9)
British J. of Occupational Therapy     Hybrid Journal   (Followers: 253, SJR: 0.323, CiteScore: 1)
British J. of Pain     Hybrid Journal   (Followers: 31, SJR: 0.579, CiteScore: 2)
British J. of Politics and Intl. Relations     Hybrid Journal   (Followers: 39, SJR: 0.91, CiteScore: 2)
British J. of Visual Impairment     Hybrid Journal   (Followers: 14, SJR: 0.337, CiteScore: 1)
British J.ism Review     Hybrid Journal   (Followers: 18)
BRQ Business Review Quarterly     Open Access   (Followers: 1)
Building Acoustics     Hybrid Journal   (Followers: 4, SJR: 0.215, CiteScore: 1)
Building Services Engineering Research & Technology     Hybrid Journal   (Followers: 3, SJR: 0.583, CiteScore: 1)
Bulletin of Science, Technology & Society     Hybrid Journal   (Followers: 9)
Business & Society     Hybrid Journal   (Followers: 15)
Business and Professional Communication Quarterly     Hybrid Journal   (Followers: 9, SJR: 0.348, CiteScore: 1)
Business Information Review     Hybrid Journal   (Followers: 17, SJR: 0.279, CiteScore: 0)
Business Perspectives and Research     Hybrid Journal   (Followers: 3)
Cahiers Élisabéthains     Hybrid Journal   (Followers: 1, SJR: 0.111, CiteScore: 0)
Calcutta Statistical Association Bulletin     Hybrid Journal   (Followers: 1)
California Management Review     Hybrid Journal   (Followers: 37, SJR: 2.209, CiteScore: 4)
Canadian Association of Radiologists J.     Full-text available via subscription   (Followers: 2, SJR: 0.463, CiteScore: 1)
Canadian J. of Kidney Health and Disease     Open Access   (Followers: 8, SJR: 1.007, CiteScore: 2)
Canadian J. of Nursing Research (CJNR)     Hybrid Journal   (Followers: 15)
Canadian J. of Occupational Therapy     Hybrid Journal   (Followers: 168, SJR: 0.626, CiteScore: 1)
Canadian J. of Psychiatry     Hybrid Journal   (Followers: 28, SJR: 1.769, CiteScore: 3)
Canadian J. of School Psychology     Hybrid Journal   (Followers: 12, SJR: 0.266, CiteScore: 1)
Canadian Pharmacists J. / Revue des Pharmaciens du Canada     Hybrid Journal   (Followers: 3, SJR: 0.536, CiteScore: 1)
Cancer Control     Open Access   (Followers: 2)
Cancer Growth and Metastasis     Open Access   (Followers: 1)
Cancer Informatics     Open Access   (Followers: 4, SJR: 0.64, CiteScore: 1)
Capital and Class     Hybrid Journal   (Followers: 10, SJR: 0.282, CiteScore: 1)
Cardiac Cath Lab Director     Full-text available via subscription   (Followers: 1)
Cardiovascular and Thoracic Open     Open Access   (Followers: 1)
Career Development and Transition for Exceptional Individuals     Hybrid Journal   (Followers: 10, SJR: 0.44, CiteScore: 1)
Cartilage     Hybrid Journal   (Followers: 6, SJR: 0.889, CiteScore: 3)
Cell Transplantation     Open Access   (Followers: 5, SJR: 1.023, CiteScore: 3)
Cephalalgia     Hybrid Journal   (Followers: 8, SJR: 1.581, CiteScore: 3)
Cephalalgia Reports     Open Access   (Followers: 4)
Child Language Teaching and Therapy     Hybrid Journal   (Followers: 34, SJR: 0.501, CiteScore: 1)
Child Maltreatment     Hybrid Journal   (Followers: 11, SJR: 1.22, CiteScore: 3)
Child Neurology Open     Open Access   (Followers: 6)
Childhood     Hybrid Journal   (Followers: 19, SJR: 0.894, CiteScore: 2)
Childhood Obesity and Nutrition     Open Access   (Followers: 12)
China Information     Hybrid Journal   (Followers: 9, SJR: 0.767, CiteScore: 2)
China Report     Hybrid Journal   (Followers: 11, SJR: 0.221, CiteScore: 0)
Chinese J. of Sociology     Full-text available via subscription   (Followers: 5)
Christian Education J. : Research on Educational Ministry     Hybrid Journal   (Followers: 1)
Chronic Illness     Hybrid Journal   (Followers: 6, SJR: 0.672, CiteScore: 2)
Chronic Respiratory Disease     Hybrid Journal   (Followers: 12, SJR: 0.808, CiteScore: 2)
Chronic Stress     Open Access  
Citizenship, Social and Economics Education     Full-text available via subscription   (Followers: 6, SJR: 0.145, CiteScore: 0)
Cleft Palate-Craniofacial J.     Hybrid Journal   (Followers: 8, SJR: 0.757, CiteScore: 1)
Clin-Alert     Hybrid Journal   (Followers: 1)
Clinical and Applied Thrombosis/Hemostasis     Open Access   (Followers: 32, SJR: 0.49, CiteScore: 1)
Clinical and Translational Neuroscience     Open Access   (Followers: 1)
Clinical Case Studies     Hybrid Journal   (Followers: 3, SJR: 0.364, CiteScore: 1)
Clinical Child Psychology and Psychiatry     Hybrid Journal   (Followers: 45, SJR: 0.73, CiteScore: 2)
Clinical EEG and Neuroscience     Hybrid Journal   (Followers: 8, SJR: 0.552, CiteScore: 2)
Clinical Ethics     Hybrid Journal   (Followers: 13, SJR: 0.296, CiteScore: 1)
Clinical Medicine Insights : Arthritis and Musculoskeletal Disorders     Open Access   (Followers: 3, SJR: 0.537, CiteScore: 2)
Clinical Medicine Insights : Blood Disorders     Open Access   (Followers: 1, SJR: 0.314, CiteScore: 2)
Clinical Medicine Insights : Cardiology     Open Access   (Followers: 8, SJR: 0.686, CiteScore: 2)
Clinical Medicine Insights : Case Reports     Open Access   (Followers: 1, SJR: 0.283, CiteScore: 1)
Clinical Medicine Insights : Circulatory, Respiratory and Pulmonary Medicine     Open Access   (Followers: 4, SJR: 0.425, CiteScore: 2)
Clinical Medicine Insights : Ear, Nose and Throat     Open Access   (Followers: 2)
Clinical Medicine Insights : Endocrinology and Diabetes     Open Access   (Followers: 34, SJR: 0.63, CiteScore: 2)
Clinical Medicine Insights : Oncology     Open Access   (Followers: 3, SJR: 1.129, CiteScore: 3)
Clinical Medicine Insights : Pediatrics     Open Access   (Followers: 3)
Clinical Medicine Insights : Psychiatry     Open Access   (Followers: 10)
Clinical Medicine Insights : Reproductive Health     Open Access   (Followers: 1, SJR: 0.776, CiteScore: 0)
Clinical Medicine Insights : Therapeutics     Open Access   (Followers: 1, SJR: 0.172, CiteScore: 0)
Clinical Medicine Insights : Trauma and Intensive Medicine     Open Access   (Followers: 4)
Clinical Medicine Insights : Urology     Open Access   (Followers: 3)
Clinical Medicine Insights : Women's Health     Open Access   (Followers: 4)
Clinical Nursing Research     Hybrid Journal   (Followers: 34, SJR: 0.471, CiteScore: 1)
Clinical Pathology     Open Access   (Followers: 5)
Clinical Pediatrics     Hybrid Journal   (Followers: 25, SJR: 0.487, CiteScore: 1)
Clinical Psychological Science     Hybrid Journal   (Followers: 16, SJR: 3.281, CiteScore: 5)
Clinical Rehabilitation     Hybrid Journal   (Followers: 78, SJR: 1.322, CiteScore: 3)
Clinical Risk     Hybrid Journal   (Followers: 5, SJR: 0.133, CiteScore: 0)
Clinical Trials     Hybrid Journal   (Followers: 22, SJR: 2.399, CiteScore: 2)
Clothing and Textiles Research J.     Hybrid Journal   (Followers: 28, SJR: 0.36, CiteScore: 1)
Collections : A J. for Museum and Archives Professionals     Full-text available via subscription   (Followers: 3)
Common Law World Review     Full-text available via subscription   (Followers: 17)
Communication & Sport     Hybrid Journal   (Followers: 8, SJR: 0.385, CiteScore: 1)
Communication and the Public     Hybrid Journal   (Followers: 2)
Communication Disorders Quarterly     Hybrid Journal   (Followers: 15, SJR: 0.458, CiteScore: 1)
Communication Research     Hybrid Journal   (Followers: 24, SJR: 2.171, CiteScore: 3)
Community College Review     Hybrid Journal   (Followers: 8, SJR: 1.451, CiteScore: 1)
Comparative Political Studies     Hybrid Journal   (Followers: 293, SJR: 3.772, CiteScore: 3)
Compensation & Benefits Review     Hybrid Journal   (Followers: 8)
Competition & Change     Hybrid Journal   (Followers: 12, SJR: 0.843, CiteScore: 2)

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Similar Journals
Journal Cover
Angiology
Journal Prestige (SJR): 0.849
Citation Impact (citeScore): 2
Number of Followers: 5  
 
  Hybrid Journal Hybrid journal (It can contain Open Access articles)
ISSN (Print) 0003-3197 - ISSN (Online) 1940-1574
Published by Sage Publications Homepage  [1166 journals]
  • Anemia: Another Stone in the Wall of Takotsubo Outcomes'

    • Free pre-print version: Loading...

      Authors: Roberto Manfredini, Alfredo De Giorgi, Fabio Fabbian
      Pages: 803 - 804
      Abstract: Angiology, Volume 72, Issue 9, Page 803-804, October 2021.

      Citation: Angiology
      PubDate: 2021-03-26T03:42:36Z
      DOI: 10.1177/00033197211005608
      Issue No: Vol. 72, No. 9 (2021)
       
  • Defining Coronary Slow Flow

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      Authors: Michael Y. Henein, Federico Vancheri
      Pages: 805 - 807
      Abstract: Angiology, Volume 72, Issue 9, Page 805-807, October 2021.

      Citation: Angiology
      PubDate: 2021-04-08T08:25:08Z
      DOI: 10.1177/00033197211007702
      Issue No: Vol. 72, No. 9 (2021)
       
  • Slow Coronary Flow: Pathophysiology, Clinical Implications, and
           Therapeutic Management

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      Authors: George Chalikias, Dimitrios Tziakas
      Pages: 808 - 818
      Abstract: Angiology, Volume 72, Issue 9, Page 808-818, October 2021.
      Coronary slow flow (CSF) is an angiographic phenomenon with specific epidemiologic characteristics, associated clinical presentation, and prognosis. Although patients with CSF are diagnosed as having “normal coronary arteries,” it seems appropriate to consider CSF as a distinct disease entity requiring specific treatment. The patient with CSF is usually male, smoker, obese, with a constellation of risk factors suggestive of metabolic syndrome. Unstable angina is the most common clinical presentation, with recurrent episodes of chest pain at rest associated with electrocardiographic changes often requiring readmission and reevaluation. Regarding definition and diagnosis, interventionists should first exclude possible “secondary” causes of CSF, use objective means for definition and then differentiate from other similar conditions such as microvascular angina. Although the phenomenon is generally benign, patients with CSF are severely symptomatic with recurrent episodes of chest pain and poor quality of life. Furthermore, acute presentation of the phenomenon is commonly life-threatening with ventricular tachyarrhythmias, conduction abnormalities, or cardiogenic shock. Acute treatment of CSF includes, but is not restricted to, intracoronary infusion of dipyridamole, adenosine, or atropine. Chronic management of patients with CSF encompasses dipyridamole, diltiazem, nebivolol, telmisartan, and/or atorvastatin associated with amelioration of angina symptoms, improved quality of life, and good prognosis.
      Citation: Angiology
      PubDate: 2021-03-29T09:19:22Z
      DOI: 10.1177/00033197211004390
      Issue No: Vol. 72, No. 9 (2021)
       
  • Impact of Baseline Neutrophil-to-Lymphocyte Ratio on Long-Term Prognosis
           in Patients With Atrial Fibrillation

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      Authors: Shuang Wu, Yan-min Yang, Jun Zhu, Jia-meng Ren, Juan Wang, Han Zhang, Xing-hui Shao
      Pages: 819 - 828
      Abstract: Angiology, Volume 72, Issue 9, Page 819-828, October 2021.
      We performed a retrospective analysis involving 1269 patients with atrial fibrillation (AF) to evaluate the predictive value of the neutrophil-to-lymphocyte ratio (NLR) on long-term outcomes. The primary outcomes were all-cause mortality and combined end point events (CEEs). Cox proportional hazards regression analysis and net reclassification improvement (NRI) analysis were performed. During a median follow-up of 3.32 years, 285 deaths and 376 CEEs occurred. With the elevation of the NLR, the incidence of all-cause mortality (2.77, 4.14, 6.12, and 12.18/100 person-years) and CEEs (4.19, 7.40, 8.03, and 15.22/100 person-years) significantly increased. Multivariate Cox analysis indicated that the highest NLR quartile was independently associated with the incidence of all-cause mortality (hazard ratio [HR] = 1.77, 95% CI: 1.19-2.65) and CEEs (HR = 1.66, 95% CI: 1.18-2.33). When the NLR was analyzed as a continuous variable, a 1-unit increment in log NLR was related to 134% increased risk of all-cause mortality and 119% increased risk of CEEs. Net reclassification improvement analysis revealed that NLR significantly improved risk stratification for all-cause death and CEEs by 15.0% and 9.6%, respectively. Neutrophil-to-lymphocyte ratio could be an independent predictor of long-term outcomes in patients with AF.
      Citation: Angiology
      PubDate: 2021-03-15T09:06:34Z
      DOI: 10.1177/00033197211000495
      Issue No: Vol. 72, No. 9 (2021)
       
  • Relationship Between C-Reactive Protein to Albumin Ratio and Coronary
           Collateral Circulation in Patients With Stable Coronary Artery Disease

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      Authors: Saban Kelesoglu, Yucel Yilmaz, Deniz Elcık
      Pages: 829 - 835
      Abstract: Angiology, Volume 72, Issue 9, Page 829-835, October 2021.
      We investigated the relationship between the C-reactive protein (CRP) to albumin ratio (CAR) and coronary collateral circulation (CCC) in stable coronary artery disease (CAD). Patients with stable CAD (n = 354) who underwent coronary angiography for suspected CAD and had a total occlusion ≥1 major coronary artery were included in the study. The participants were divided into 2 groups according to the Rentrop score as satisfactory CCC (Rentrop 2-3) and poor CCC (Rentrop 0-1). Patients who had poor CCC had a higher CRP, neutrophil/lymphocyte ratio (NLR), and CAR levels compared with those who had satisfactory CCC (P < .001, P = .046, P < .001, respectively). The CAR (odds ratio: 3.522, 95% CI: 2.515-4.932, P < .001), CRP, NLR, and diabetes mellitus were independent predictors of poor CCC. In receiver operator characteristic curve (ROC) analysis, the optimal cutoff value of CAR to predict poor CCC was 1.27 (area under ROC curve = 0.735 [95% CI: 0.667-0.803], P < .001). A raised CAR may be an independent predictor of poor CCC.
      Citation: Angiology
      PubDate: 2021-03-24T09:30:54Z
      DOI: 10.1177/00033197211004392
      Issue No: Vol. 72, No. 9 (2021)
       
  • Balloon Angioplasty Versus Stenting in Patients With ST-Elevated
           Myocardial Infarction Before Subsequent Coronary Artery By-Pass Grafting

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      Authors: Gokturk Ipek, Muhammed Keskin, Mustafa Aldag, Edibe Betul Borklu, Duygu Inan, Hale Yilmaz, Murat Demirtas, Osman Bolca
      Pages: 836 - 841
      Abstract: Angiology, Volume 72, Issue 9, Page 836-841, October 2021.
      Decision of ad hoc revascularization strategy in patients who require coronary artery bypass grafting (CABG) following primary percutaneous coronary interventions (PCI) is challenging due to the pros and cons of only-ballooning and stenting. In this study, we aimed to compare the outcomes of only-balloon-angioplasty to stenting in primary PCI in patients with ST elevated myocardial infarction (STEMI) who required a subsequent CABG. We retrospectively analyzed 350 consecutive STEMI patients who needed CABG in addition to primary balloon angioplasty (n = 160) and stenting strategy (n = 190). In-hospital and 5-year outcomes of the patients were compared between the 2 groups. In-hospital mortality rates in the ballooning and stenting groups were not nonsignificantly different (11.2% vs 9.5%, respectively, P = .59); 5-year mortality rates were also similar between the 2 groups (9.2% vs 8.7%, P = .89). Additionally, major bleeding rates (3.8% vs 6.3%, P = .28) did not differ between the 2 groups. In conclusion, our study showed no significant difference in-hospital and long-term mortality rates in patients who require CABG after primary PCI irrespective of the ad hoc revascularization strategy.
      Citation: Angiology
      PubDate: 2021-04-20T07:22:21Z
      DOI: 10.1177/00033197211007713
      Issue No: Vol. 72, No. 9 (2021)
       
  • Anemia Is Associated With Poor Clinical Outcomes in Hospitalized Patients
           With Takotsubo Cardiomyopathy

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      Authors: Xiaojia Lu, Pengyang Li, Catherine Teng, Peng Cai, Bin Wang
      Pages: 842 - 849
      Abstract: Angiology, Volume 72, Issue 9, Page 842-849, October 2021.
      The association between anemia and Takotsubo cardiomyopathy (TCM) has not been well studied. To assess the effect of anemia on patients hospitalized with TCM, we identified 4733 patients with a primary diagnosis of TCM from the 2016 to 2018 National Inpatient Sample (NIS) database (the United States) using the International Classification of Diseases, 10th edition, Clinical Modification (ICD-10-CM) code. Of these, 603 (12.7%) patients had a comorbidity of anemia and 4130 did not. After propensity score matching, we compared the in-hospital outcomes between the 2 groups (anemia vs nonanemia, n = 594 vs 1137). Patients with TCM with anemia had significantly higher rates of in-hospital complications, including cardiogenic shock (11.4% vs 4.0%, P < .001), ventricular arrhythmia (6.6% vs 3.6%, P = .008), acute kidney injury (22.7% vs 13.1%, P < .001), acute respiratory failure (22.6% vs 13.1%, P < .001), longer length of hospital stay (5.6 ± 5.8 days vs 3.6 ± 3.6 days, P < .001), and higher total charges (US$79 586 ± 10 2436 vs US$50 711 ± 42 639, P < .001). In conclusion, patients with anemia who were admitted for TCM were associated with a higher incidence of in-hospital complications compared with those without anemia.
      Citation: Angiology
      PubDate: 2021-03-09T09:50:34Z
      DOI: 10.1177/0003319721999492
      Issue No: Vol. 72, No. 9 (2021)
       
  • Endocan: A Novel Predictor of Endothelial Dysfunction in Silent Brain
           Infarction

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      Authors: Yuksel Erdal, Nurettin Yavuz, Osman Oguz, Abdullah Soydan Mahmutoglu, Ufuk Emre
      Pages: 850 - 854
      Abstract: Angiology, Volume 72, Issue 9, Page 850-854, October 2021.
      Silent brain infarction (SBI) has been considered as a subclinical risk factor for symptomatic possible future stroke. We investigated the association between serum inflammatory markers and SBI. Patients (n = 54) diagnosed with SBI as the study group and 52 individuals as the control group were included in this study. Silent brain infarction is defined as a hyperintense lesion that was ≥3 mm in 1 dimension on fluid-attenuated inversion recovery T2-weighted magnetic resonance image, if the patient had normal neurological examination or had an abnormality that was not consistent with the brain lesion locations, after being evaluated by a neurologist. Serum endocan levels (P = .036) and high-sensitivity C-reactive protein (hsCRP; P = .022) were significantly higher in patients with SBI than the controls. Pentraxin 3, erythrocyte sedimentation rate, white blood count, lymphocyte, monocyte, neutrophil, low-density lipoprotein, and triglyceride levels were not significantly different when comparing the groups with and without SBI. There was a significant correlation (r = −0.196; P = .16) between hsCRP and endocan levels in the SBI group. Endocan, a novel biomarker of endothelial pathology, was significantly increased in patients with SBI and may be useful to predict the future risk of stroke.
      Citation: Angiology
      PubDate: 2021-04-27T07:48:50Z
      DOI: 10.1177/00033197211012135
      Issue No: Vol. 72, No. 9 (2021)
       
  • Angiogenin—A Proposed Biomarker for Cardiovascular Disease—Is Not
           Associated With Long-Term Survival in Patients With Peripheral Artery
           Disease

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      Authors: Clemens Höbaus, Gerfried Pesau, Bernhard Zierfuss, Renate Koppensteiner, Gerit-Holger Schernthaner
      Pages: 855 - 860
      Abstract: Angiology, Volume 72, Issue 9, Page 855-860, October 2021.
      We evaluated angiogenin as a prospective biomarker in peripheral artery disease (PAD) patients with and without claudication symptoms. A pilot study suggested an elevation of angiogenin in critical limb ischemia. However, in PAD patients, the predictive value of angiogenin has not yet been evaluated. For this purpose, 342 patients with PAD (age: 69 ± 10 years, 34.5% women) were followed-up for 7 years in a cross-sectional study. Angiogenin was measured by enzyme-linked immunosorbent assay. All-cause and cardiovascular mortality were analyzed by Cox regression. Angiogenin levels were higher in men (P = .001) and were associated with patient waist-to-hip ratio (P < .001), fasting triglycerides (P = .011), and inversely with estimated glomerular filtration rate (P = .009). However, angiogenin showed no association with age, characteristics of diabetes, markers of lipid metabolism, or C-reactive protein. Angiogenin did not correlate with markers of angiogenesis such as vascular endothelial growth factor, angiopoietin-2, or tie-2. Furthermore, angiogenin was not associated with PAD Fontaine stages or with patient ankle-brachial index in addition to all-cause mortality (hazard ratio [HR] = 1.09 [95% CI: 0.89-1.34]) or cardiovascular morality (HR = 1.05 [0.82-1.35]). These results suggest that angiogenin does not provide further information regarding outcome prediction in patients with PAD.
      Citation: Angiology
      PubDate: 2021-03-29T09:20:01Z
      DOI: 10.1177/00033197211004393
      Issue No: Vol. 72, No. 9 (2021)
       
  • Main Factors Predicting Nonresponders to Autologous Cell Therapy for
           Critical Limb Ischemia in Patients With Diabetic Foot

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      Authors: Michal Dubský, Vladimíra Fejfarová, Robert Bem, Alexandra Jirkovská, Andrea Nemcová, Karol Sutoris, Jitka Husáková, Jelena Skibová, Edward B. Jude
      Pages: 861 - 866
      Abstract: Angiology, Volume 72, Issue 9, Page 861-866, October 2021.
      Autologous cell therapy (ACT) is a new treatment for patients with no-option critical limb ischemia (NO-CLI). We evaluated the factors involved in the nonresponse to ACT in patients with CLI and diabetic foot. Diabetic patients (n = 72) with NO-CLI treated using ACT in our foot clinic over a period of 8 years were divided into responders (n = 57) and nonresponders (n = 15). Nonresponder was defined as an insufficient increase in transcutaneous oxygen pressure by
      Citation: Angiology
      PubDate: 2021-03-30T09:14:48Z
      DOI: 10.1177/00033197211005614
      Issue No: Vol. 72, No. 9 (2021)
       
  • Inflammatory Indicators and Hematological Indices in Contrast-Induced
           Nephropathy Among Patients Receiving Coronary Intervention: A Systematic
           Review and Meta-Analysis

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      Authors: Xiaoyan Wu, Chao Ma, Daqing Sun, Guojing Zhang, Jinmiao Wang, Enyuan Zhang
      Pages: 867 - 877
      Abstract: Angiology, Volume 72, Issue 9, Page 867-877, October 2021.
      Strong inflammatory indicators such as C-reactive protein (CRP), high-sensitivity CRP (hsCRP), and hematological indices, including platelet to lymphocyte ratio (PLR), neutrophil to lymphocyte ratio (NLR), hematocrit (HCT), and red blood cell distribution width (RDW), may be related with contrast-induced nephropathy (CIN). Our meta-analysis aimed at exploring the relationship between these indicators and CIN incidence among patients undergoing coronary intervention. Clinical studies were retrieved from the electronic databases of PubMed, EMBASE, Google Scholar, Clinical Trials, and Science Direct from their inception to June 3, 2020. Meta-analysis was performed on pooled eligible studies. Finally, 26 studies involving 29 454 patients were included. Pooled analysis revealed that patients with higher CRP (odds ratio [OR] = 1.06, 95% CI: 1.01-1.12, P = .02), hsCRP (OR = 1.03, 95% CI: 1.01-1.06, P = .004), NLR (OR = 1.11, 95% CI: 1.01-1.20, P = .02), RDW (OR = 1.35, 95% CI: 1.19-1.53, P < .001), and lower HCT (OR = 0.94, 95% CI: 0.92-0.97, P = .003) all exhibited significantly higher CIN rates, but there was no significant association between PLR and CIN risk (OR = 1.12, 95% CI: 0.99-1.26, P = .07). Pre-angiography CRP/hsCRP and some hematological indices are associated with CIN.
      Citation: Angiology
      PubDate: 2021-03-15T09:05:34Z
      DOI: 10.1177/00033197211000492
      Issue No: Vol. 72, No. 9 (2021)
       
  • Efficacy of Alprostadil in Preventing Contrast-Induced Nephropathy: A
           Systematic Review and Meta-Analysis

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      Authors: Hongling Xu, Hongye Wang, Chuang Zhang, Jun Xiao, Ning Hua, Xuezheng Tang, Jiaqi Xie, Zhengbin Zhang
      Pages: 878 - 888
      Abstract: Angiology, Volume 72, Issue 9, Page 878-888, October 2021.
      This study aimed to determine the efficacy of alprostadil in preventing contrast-induced nephropathy (CIN). Eligible studies were searched using the keywords through the databases of PubMed, Cochrane, Embase, China Biological Medicine Database, China National Knowledge Infrastructure, and Vanfun. Quality evaluation of the included studies was conducted according to international evidence evaluation and recommended Grades of Recommendations Assessment, Development, and Evaluation standards. We included 29 studies with 5623 patients. Compared with hydration, 10 µg/d alprostadil or 20 µg/d alprostadil plus hydration significantly decreased the incidence of CIN. Compared with hydration, alprostadil plus hydration significantly reduced serum creatinine and blood urea nitrogen at 24, 48, and 72 hours and 7 days after coronary angiography (CAG). Alprostadil (20 µg/d) plus hydration significantly decreased serum cystatin versus hydration at 24, 48, and 72 hours after CAG. Compared with hydration, alprostadil plus hydration significantly increased glomerular filtration rate at 24 and 72 hours after CAG. Alprostadil plus hydration significantly decreased neutrophil gelatinase-associated lipocalin levels compared to hydration at 24, 48, and 72 hours after CAG. Alprostadil plus hydration significantly decreased urine macroglobulin versus hydration at 24 and 48 hours after CAG.
      Citation: Angiology
      PubDate: 2021-04-15T07:54:25Z
      DOI: 10.1177/00033197211004412
      Issue No: Vol. 72, No. 9 (2021)
       
  • Systemic Immune Inflammation Index: A Novel Predictor of Contrast-Induced
           Nephropathy in Patients With Non-ST Segment Elevation Myocardial
           Infarction

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      Authors: Saban Kelesoglu, Yucel Yilmaz, Deniz Elcık, Zeki Çetınkaya, Mehmet Tugrul Inanc, Ali Dogan, Abdurrahman Oguzhan, Nihat Kalay
      Pages: 889 - 895
      Abstract: Angiology, Volume 72, Issue 9, Page 889-895, October 2021.
      We investigated whether the systemic immune inflammation index (SII) on admission is an independent risk factor that predicts the development of contrast-induced nephropathy (CIN) in patients with non-ST segment elevation myocardial infarction (NSTEMI) who underwent percutaneous coronary intervention (PCI). A total of 429 patients with NSTEMI were enrolled in the study. Contrast-induced nephropathy was defined as an increase in serum creatinine level of ≥0.5 mg/dL or ≥25% above baseline within 72 hour after the procedure. Patients were divided into 2 groups: with and without CIN. Demographics, clinical risk factors, angiographic and laboratory parameters, CIN incidence, and SII score were compared between the 2 groups. Non-ST segment elevation myocardial infarction patients, who developed CIN, had higher glucose levels (P = .009), neutrophil counts (P < .001), platelet counts (P < .001), neutrophil-lymphocyte ratios (P < .001), high sensitivity C-reactive protein levels (P = .009), and SII levels (P < .001) than those who did not develop CIN. The receiver operating characteristic curve analysis showed that at a cutoff of 933.2, the value of SII exhibited 77.6% sensitivity and 69.2% specificity for detecting CIN. Our study showed that the SII levels on admission were independently associated with CIN development after PCI in patients with NSTEMI.
      Citation: Angiology
      PubDate: 2021-04-08T08:25:56Z
      DOI: 10.1177/00033197211007738
      Issue No: Vol. 72, No. 9 (2021)
       
  • Mehran Risk Score Is Still Valuable for Prediction of Contrast Nephropathy
           in Patients With Acute Coronary Syndrome

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      Authors: Ahmet Goktug Ertem, Mehmet Akif Erdol, Koray Demirtas, Cagri Yayla, Adnan Burak Akcay
      Pages: 896 - 896
      Abstract: Angiology, Volume 72, Issue 9, Page 896-896, October 2021.

      Citation: Angiology
      PubDate: 2021-06-07T09:17:19Z
      DOI: 10.1177/00033197211022093
      Issue No: Vol. 72, No. 9 (2021)
       
  • Plasma Leukocyte Cell-Derived Chemotaxin 2 for the Severity of Coronary
           Artery Disease

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      Authors: Mehmet Kadri Akboga, Ibrahim Halil Inanc
      Abstract: Angiology, Ahead of Print.

      Citation: Angiology
      PubDate: 2021-10-11T10:56:54Z
      DOI: 10.1177/00033197211047326
       
  • A Clinical Score to Predict “Corrected Thrombolysis in Myocardial
           Infarction Frame Count” in Patients With ST-Segment Elevation Myocardial
           Infarction Undergoing Primary Percutaneous Coronary Intervention

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      Authors: Flora Ozkalayci, Erdem Türkyılmaz, Ali Karagoz, Can Yucel Karabay, İbrahim Halil Tanboga, Vecih Oduncu
      Abstract: Angiology, Ahead of Print.
      Corrected thrombolysis in myocardial infarction frame count (cTFC) is an objective, simple, and reproducible method to assess coronary blood flow which is a surrogate for cardiovascular outcomes. It is important to learn which factors are associated with cTFC. The goal of this study was to determine predictive models for epicardial blood flow assessed by cTFC and develop a diagnostic predictive model that indicates the individualized assessment of epicardial blood flow prior to primary percutaneous coronary intervention. This is a retrospective study including 3205 patients with ST-segment elevation myocardial infarction who underwent pPCI. The primary outcome was cTFC. Multivariable linear regression analysis was performed. Subsequently, a nomogram was developed to predict cTFC according to the candidate predictors. Median age was 58; the number of male patients was 2381 (74.3%). Median value of cTFC was 22 and interquartile range (IQR): 16.5–28.0). Age, diabetes mellitus (DM), total ischemic time, systolic blood pressure (SBP), heart rate (HR), and history of statin use remained in both full and reduced models. Our model may potentially allow clinicians to identify patients at high risk for impaired epicardial perfusion.
      Citation: Angiology
      PubDate: 2021-10-09T05:52:45Z
      DOI: 10.1177/00033197211045021
       
  • Sex Differences of Extracorporeal Membrane Oxygenation Distribution Among
           SARS-COV-2 Cases

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      Authors: Frank H Annie, Sahil Dave, Aravinda Nanjundappa, Debabrata Mukherjee
      Abstract: Angiology, Ahead of Print.

      Citation: Angiology
      PubDate: 2021-10-08T02:12:43Z
      DOI: 10.1177/00033197211049748
       
  • Analysis of Interwoven Nitinol Stenting for the Treatment of Critical Limb
           Ischemia: Outcomes From an Average 3-Year Follow-up Period

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      Authors: Prakash Krishnan, Arthur Tarricone, Allen Gee, Serdar Farhan, Haroon Kamran, Vishal Kapur, Karthik Gujja, Annapoorna Kini, Samin Sharma
      Abstract: Angiology, Ahead of Print.
      We assessed the clinical outcomes of patients with critical limb-threatening ischemia (CLTI) who underwent interwoven nitinol stent (Supera) implantation for significant stenoses of the femoropopliteal segment. In this retrospective cohort study, 116 consecutive patients with CLTI who were treated with Supera stents between September 2015 and March 2020 were included in this analysis. Primary endpoint analysis was completed for amputation-free survival, target lesion revascularization (TLR), and mortality. After a mean follow-up time of 3.4 years, 21 (18%) patients had undergone amputations, 3 (2.6%) died, and, overall, the amputation-free survival rate was 81%. TLR occurred in 21 (18%) patients, resulting in the freedom from target lesion revascularization of 82%. The average Wagner score for all patients was 2.8 ± 1.1. A subgroup analysis of 57 patients revealed a median ulcer size of 3.0 cm2 [1.65, 9.0], with complete healing for 45 patients by 20 months. The Wagner score of this subgroup decreased by an average of 3.4 ± .9 points. Supera stents can be used together with other endovascular therapies and are a safe and effective treatment modality for CLTI.
      Citation: Angiology
      PubDate: 2021-10-07T01:38:11Z
      DOI: 10.1177/00033197211043406
       
  • Pancretic Fat Accummulation is Associated with Subclinical Atherosclerosis

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      Authors: Sinan Sahin, Aysegul Karadeniz
      Abstract: Angiology, Ahead of Print.
      We investigated the relationship between pancreatic fat accumulation and markers of atherosclerosis among patients with nonalcoholic fatty liver disease (NAFLD). Patients with NAFLD have been reported to be at an increased risk of vascular events. We grouped 183 patients in whom we detected and graded hepatosteatosis (HS) on transabdominal ultrasonography into 2 groups based on the presence/absence of pancreatic fat. There were 85 participants (50 female; mean age: 53.6 ± 9.7 years) who were nonalcoholic fatty pancreas disease (NAFPD) positive and 98 participants (56 female; mean age: 51.4 ± 9.3 years) who were NAFPD negative. Carotid intima media thickness (cIMT) was significantly greater in the group where HS was accompanied by NAFPD (0.51 [0.40–0.62] vs 0.45 [0.35–0.55] mm; P < .001). Multivariable analyses showed that the independent predictors of increased cIMT were age (odds ratio [OR]: 1.108; 95% CI: 1.059–1.158, P = .001), hypertension (OR: 2.244; 95% CI: 1.099–4.579, P = .026), and the presence of NAFPD (OR: 3.078; CI 95% CI: 1.531–6.190, P = .0002). In the present study we demonstrated that, in patients with NAFLD, pancreatic fat accumulation was significantly associated with cIMT, a marker of early atherosclerosis. NAFPD may increase the risk of vascular events associated with NAFLD.
      Citation: Angiology
      PubDate: 2021-10-05T07:02:56Z
      DOI: 10.1177/00033197211038334
       
  • The CHA2DS2-VASc Risk Score Predicts Total Occlusion in Infarct-Related
           Arteries in Patients With NSTEMI: Reply

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      Authors: Erdoğan Yaşar, Adil Bayramoğlu, Yasin Karakuş, Tolga Çakmak
      Abstract: Angiology, Ahead of Print.

      Citation: Angiology
      PubDate: 2021-10-05T06:33:38Z
      DOI: 10.1177/00033197211048047
       
  • Effect of Sacubitril/Valsartan Combined with Dapagliflozin on Long-Term
           Cardiac Mortality in Heart Failure with Reduced Ejection Fraction

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      Authors: Umut Karabulut, Kudret Keskin, Dilay Karabulut, Ece Yiğit, Zerrin Yiğit
      Abstract: Angiology, Ahead of Print.
      The angiotensin receptor–neprilysin inhibitor (ARNI) sacubitril/valsartan and sodium-glucose cotransporter-2 (SGLT-2) inhibitor dapagliflozin have been shown to reduce rehospitalization and cardiac mortality in patients with heart failure (HF) with reduced ejection fraction (HFrEF). We aimed to compare the long-term cardiac and all-cause mortality of ARNI and dapagliflozin combination therapy against ARNI monotherapy in patients with HFrEF. This retrospective study involved 244 patients with HF with New York Heart Association (NYHA) class II–IV symptoms and ejection fraction ≤40%. The patients were divided into 2 groups: ARNI monotherapy and ARNI+dapagliflozin. Median follow-up was 2.5 (.16–3.72) years. One hundred and seventy-five (71.7%) patients were male, and the mean age was 65.9 (SD, 10.2) years. Long-term cardiac mortality rates were significantly lower in the ARNI+dapagliflozin group (7.4%) than in the ARNI monotherapy group (19.5%) (P = .01). Dapagliflozin [Hazard Ratio (HR) [95% Confidence Interval (CI)] = .29 [.10–.77]; P = .014] and left ventricular ejection fraction (LVEF) [HR (95% CI) = .89 (.85–.93); P < .001] were found to be independent predictors of cardiac mortality. Our study showed a significant reduction in cardiac mortality with ARNI and dapagliflozin combination therapy compared with ARNI monotherapy.
      Citation: Angiology
      PubDate: 2021-09-25T06:14:34Z
      DOI: 10.1177/00033197211047329
       
  • Response to Letter Entitled ‘Indicators of Amputation in Patients with
           Critical Limb Ischemia’ by Ata Y. et al.

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      Authors: Gökhan Ceyhun, Muhammed Ç. Engin
      Abstract: Angiology, Ahead of Print.

      Citation: Angiology
      PubDate: 2021-09-24T11:20:09Z
      DOI: 10.1177/00033197211048295
       
  • Walking Impairment Questionnaire and Walking Tests are Reliable Indicators
           of Success of Treatment of Peripheral Artery Disease

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      Authors: Pavel Poredos, Vinko Boc, Urska Zlajpah, Ana Spirkoska Mangaroska, Peter Poredos
      Abstract: Angiology, Ahead of Print.
      The functional capacity of patients with peripheral arterial disease (PAD) represents an important indicator of patient health and quality of life. The aim of this prospective study was to investigate the validity of a walking impairment questionnaire (WIQ) compared with walking tests for the estimation of the therapeutic effect of lower limb revascularization. The study included 36 patients with PAD in whom successful percutaneous revascularization of a lower limb was performed due to disabling intermittent claudication. Before the revascularization procedure and 4–6 weeks after successful revascularization, clinical examination, ankle brachial index (ABI) measurement, 6-min walk test, treadmill test, and WIQ were performed. After revascularization, significant improvement in walking capacity was shown by both 6-min walk test and treadmill exercise test as well as with WIQ. However, the increase in ABI was borderline. Significant correlations between improvement of 6-min walk test and treadmill exercise test results and the sum of WIQ points were found. The ABI was significantly correlated with treadmill maximal walking distance only. According to our results, the WIQ correlates well with walking tests and is a reliable indicator of effective revascularization of lower limb arterial occlusions, even in patients with a nonsignificant improvement of the ABI.
      Citation: Angiology
      PubDate: 2021-09-23T04:02:34Z
      DOI: 10.1177/00033197211045281
       
  • Adverse Prognosis of Peripheral Artery Disease Treatments Associated With
           Diabetes: A Comprehensive Meta-Analysis

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      Authors: Jingyang Luan, Jie Xu, Weiquan Zhong, Yan Zhou, Hao Liu, Kai Qian
      Abstract: Angiology, Ahead of Print.
      Many studies have investigated the influence of diabetes mellitus (DM) on outcomes in patients with peripheral artery disease (PAD). We performed a meta-analysis of the outcomes of PAD treatments in DM patients compared with those without DM. Long-term mortality was the primary endpoint. Secondary endpoints were in-hospital/30-day mortality, primary/secondary patency, amputation, and limb salvage. Thirty-one studies reporting 58113 patients were eligible for enrollment. The mean follow-up duration ranged from 1 to 89 months. DM was significantly associated with long-term mortality (relative risk (RR) = 1.67; 95% confidence intervals (CI), 1.43–1.94; P < .001). DM was also associated with significantly lower primary patency (RR = 0.74; 95% CI, 0.58–0.95; P = .001) and secondary patency (RR = 0.80; 95% CI, 0.67–0.96; P = .009). DM is associated with worse outcomes and adverse prognosis of treatment in patients with PAD, and may therefore be a modifiable risk factor for poor prognosis in PAD patients.
      Citation: Angiology
      PubDate: 2021-09-21T07:31:24Z
      DOI: 10.1177/00033197211042494
       
  • Pro- and Anti-Angiogenic Factors: Their Relevance in Diabetic Foot
           Syndrome—A Review

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      Authors: Martyna Schönborn, Patrycja Łączak, Paweł Pasieka, Sebastian Borys, Anna Płotek, Paweł Maga
      Abstract: Angiology, Ahead of Print.
      Peripheral arterial disease can involve tissue loss in up to 50% of patients with diabetic foot syndrome (DFS). Consequently, revascularization of narrowed or occluded arteries is one of the most common forms of comprehensive treatment. However, technically successful angioplasty does not always result in the healing of ulcers. The pathomechanism of this phenomenon is still not fully understood, but inadequate angiogenesis in tissue repair may play an essential role. Changes in pro- and anti-angiogenic factors among patients with DFS are not always clear and conclusive. In particular, some studies underline the role of decreased concentration of pro-angiogenic factors and higher levels of anti-angiogenic mediators. Nevertheless, there are still controversial issues, including the paradox of impaired wound healing despite high concentrations of some pro-angiogenic factors, dynamics of their expression during the healing process, and their mutual relationships. Exploring this process among diabetic patients may provide new insight into well-known methods of treatment and show their real benefits and chances for improving outcomes.
      Citation: Angiology
      PubDate: 2021-09-20T11:51:17Z
      DOI: 10.1177/00033197211042684
       
  • Letter Circulating microRNA-221 and 222 for the Severity of Coronary
           Artery Disease in Acute Coronary Syndrome

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      Authors: Mehmet Kadri Akboga, Ridvan Yalcin
      Abstract: Angiology, Ahead of Print.

      Citation: Angiology
      PubDate: 2021-09-16T11:42:53Z
      DOI: 10.1177/00033197211045200
       
  • Retinal Layer Thickness after Transcatheter Aortic Valve Replacement

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      Authors: Mehmet A Erdol, Yunus E Özbebek, İnci E Erbahceci timur, Nagihan Ugurlu, Engin Bozkurt
      Abstract: Angiology, Ahead of Print.

      Citation: Angiology
      PubDate: 2021-09-13T05:54:59Z
      DOI: 10.1177/00033197211038491
       
  • Three-Year Clinical Outcomes Following Implantation of LifeStent
           Self-Expanding Nitinol Stents in Patients With Femoropopliteal Artery
           Lesions

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      Authors: Michinao Tan, Mitsuyoshi Takahara, Yoshimitsu Soga, Shinsuke Mori, Taketsugu Tsuchiya, Toru Mazaki, Yoshiaki Shintani, Masahiko Noguchi, Masahito Taniguchi, Yohei Kobayashi, Jun Nakazato, Kazushi Urasawa
      Abstract: Angiology, Ahead of Print.
      The aim of this study was to evaluate midterm clinical outcomes after implantation of LifeStent self-expanding nitinol stents for the treatment of femoropopliteal lesions. This retrospective, multicenter, non-randomized study examined 260 femoropopliteal lesions in 250 consecutive patients with peripheral artery disease implanted with LifeStents from April 2016 to April 2017. The prevalence of chronic total occlusion (CTO), lesion length ≥25 cm, and distal reference vessel diameter (RVD)
      Citation: Angiology
      PubDate: 2021-09-08T08:46:20Z
      DOI: 10.1177/00033197211042685
       
  • Under-Prescription of Medical Treatment for Peripheral Artery Disease in
           the Under 50s: A Retrospective Study

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      Authors: Simon Soudet, Lorène Bultel, Lamrani Adnane, Thierry Reix, Marie Antoinette Sevestre
      Abstract: Angiology, Ahead of Print.
      Peripheral artery disease (PAD) is a common cause of morbidity and mortality; however, data on its etiology and evolution in patients under 50 years old are scarce. Therefore, we performed a retrospective analysis of data from medical records, including cardiovascular risk factors, etiology, medical and surgical treatment, and follow-up. We included all patients with PAD aged between 18 and 50 years attending our university hospital between 2005 and 2015. Of the 87 patients included, 32 (36%) were women. Smoking was acknowledged by 81 patients (93%), and 37 had dyslipidemia (42.5%). Median follow-up was 24 months (10-59). Recurrence occurred in 41 patients (47.1%), all active smokers, with a median delay of 14 months (7-47). Acute limb ischemia at diagnosis was significantly associated with major amputation, odds ratio (OR) 5.95 (95%CI 1.41-40.90, P = .029), which was needed by 11 patients (12.6%). Treatments included antiplatelet therapy (76; 87.4%), statins (67; 77%), and anti-hypertensives (60; 69%), and 29 (32.1%) patients benefited from vascular rehabilitation. This cohort of relatively young patients with PAD showed a high level of symptom recurrence. Atherosclerosis was the most common etiology. Our study revealed that medical treatment is often under-prescribed in this age group and needs to be improved.
      Citation: Angiology
      PubDate: 2021-09-06T01:40:16Z
      DOI: 10.1177/00033197211042155
       
  • Prognostic Value of 3 Nutritional Screening Tools to Predict 30-Day
           Outcome in Patients Undergoing Carotid Artery Stenting

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      Authors: Ender Ö Çakmak, Lütfi Öcal, Emrah Erdoğan, Sinan Cerşit, Süleyman Çağan Efe, Ali Karagöz, Fatih Yılmaz, Serdar Fidan, Elnur Alizade, Regayip Zehir, Cevat Kırma
      Abstract: Angiology, Ahead of Print.
      The effect of malnutrition on outcomes after carotid artery stenting (CAS) is not well known. This study reports the relationship between malnutrition and post-procedure 30-day major adverse events (MAEs). A total of 978 patients hospitalized for CAS were enrolled in the study. Controlling nutritional status (CONUT) score, the nutritional risk index (NRI), and the prognostic nutritional index (PNI) were calculated. MAEs (myocardial infarction, stroke/transient ischemic attack and mortality) were compared. According to the CONUT score, NRI, and PNI, 9.4%, 41%, and 11.4% patients were moderately or severely malnourished, respectively; 74.8% were at least mildly malnourished by at least 1 score. Forty-seven patients (4.8%) had a post-procedure 30-day MAE. Continuous classifications of the indexes were independently associated with higher MAE. CONUT showed the highest predictive ability, whereas NRI had the lowest (C-index: CONUT, 0.701; NRI, 0.681; PNI, 0.688). According to categorical classification of indexes, only CONUT and PNI showed predictive ability for MAE. Malnutrition assessment could identify patients with CAS at elevated risk for MAE. CONUT, NRI, and PNI continuous scores were independent prognostic factors for the post-procedure 30-day MAE. According to our study, CONUT showed the highest predictive ability.
      Citation: Angiology
      PubDate: 2021-08-31T10:32:02Z
      DOI: 10.1177/00033197211040365
       
  • Biomarkers of Contrast-Induced Nephropathy After Non-cardiac Vascular
           Procedures: An Under-explored Area

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      Authors: Fabien Lareyre, Juliette Raffort
      Abstract: Angiology, Ahead of Print.

      Citation: Angiology
      PubDate: 2021-08-31T08:46:34Z
      DOI: 10.1177/00033197211042151
       
  • Biomarkers for the early prediction of contrast-induced nephropathy after
           percutaneous coronary intervention in adults: A systematic review and
           meta-analysis

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      Authors: Jing Lin, Jialong Chen, Dansen Wu, Xiuhua Li, Xiaolan Guo, Songjing Shi, Kaiyang Lin
      Abstract: Angiology, Ahead of Print.
      Contrast-induced nephropathy (CIN) is a complication of patients undergoing percutaneous coronary intervention (PCI). Promising biomarkers for the early prediction of CIN can significantly improve outcomes of these patients. We searched PubMed, EMBASE, Web of Science, and Cochrane Library for studies. Trials reporting an area under the curve (AUC) for the utility of novel biomarkers in the early prediction of CIN in adults after PCI were included. In total, 42 studies comprising 11,984 adult patients undergoing PCI met the criteria. Four urinary biomarkers and four blood biomarkers were included. For urine biomarkers, the pooled AUCs for neutrophil gelatinase-associated lipocalin (NGAL), interleukin-18 (IL-18), liver-type fatty acid-binding protein (L-FABP), and kidney injury molecule-1 (KIM-1) were 0.91 (95% CI 0.89–0.94), 0.79 (0.75–0.82), 0.78 (0.74–0.82), and 0.79 (0.76–0.83), respectively. The blood biomarkers NGAL, cystatin C, brain natriuretic peptide (BNP), and C-reactive protein (CRP) had pooled AUCs of 0.93 (0.91–0.95), 0.92 (0.89–0.94), 0.78 (0.74–0.81), and 0.75 (0.71–0.79), respectively. Subgroup analysis showed that blood NGAL in early CIN predictive time (
      Citation: Angiology
      PubDate: 2021-08-31T03:58:16Z
      DOI: 10.1177/00033197211039921
       
  • Acute Kidney Injury Following Percutaneous Coronary Intervention for Acute
           Coronary Syndrome: Incidence, Aetiology, Risk Factors and Outcomes

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      Authors: Elliott J Carande, Karen Brown, David Jackson, Nicholas Maskell, Loukas Kouzaris, Giles Greene, Ashraf Mikhail, Daniel R Obaid
      Abstract: Angiology, Ahead of Print.
      We investigated the predictors, aetiology and long-term outcomes of acute kidney injury (AKI) following urgent percutaneous coronary intervention (PCI) for acute coronary syndrome (ACS). Acute kidney injury occurred in 198 (7.2%) of 2917 patients: 14.1% of AKI cases were attributed to cardiogenic shock and 5.1% were classified as atheroembolic renal disease (AERD). Significant risk factors for AKI included age (odds ratio [OR] 1.05, 95% confidence limits [CI] 1.03-1.06), diabetes (OR 1.73, 95% CI 1.20-2.47), hypertension (OR 1.43, 95% CI 1.03-2.00), heart failure (OR 3.01, 95% CI 1.58-5.57), femoral access (OR 1.50, 95% CI 1.03-2.15), cardiogenic shock (OR 2.03, 95% CI 1.19-3.37) and ST-elevation myocardial infarction (STEMI) (OR 3.89, 95% CI 2.80-5.47). One-year mortality after AERD was 44.4% and renal replacement therapy (RRT) requirement 22.2% (compared with mortality 33.3% and RRT requirement 7.4%, respectively, in all other AKI patients). Mortality at 1 year was associated with AKI (OR 4.33, 95% CI 2.89-6.43), age (OR 1.08, 95% CI 1.06-1.09), heart failure (OR 1.92, 95% CI 1.05-3.44), femoral access (OR 2.05, 95% CI 1.41-2.95) and cardiogenic shock (OR 3.63, 95% CI 2.26-5.77). Acute kidney injury after urgent PCI is strongly associated with worse outcomes. Atheroembolic renal disease has a poor outcome and a high likelihood of long-term RRT requirement.
      Citation: Angiology
      PubDate: 2021-08-28T01:01:32Z
      DOI: 10.1177/00033197211040375
       
  • A Promising Inflammatory Marker for the Prediction of Contrast-Induced
           Nephropathy in STEMI Patients: Systematic Immune-Inflammation Index

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      Authors: Tufan Çınar, Mert I. Hayıroğlu, Vedat Çiçek, Murat Selçuk, Suha Asal, Samet Yavuz, Mert Babaoğlu, Ahmet L. Orhan
      Abstract: Angiology, Ahead of Print.

      Citation: Angiology
      PubDate: 2021-08-27T01:33:14Z
      DOI: 10.1177/00033197211040358
       
  • Admission Hyperglycemia is Associated with Global Registry of Acute
           Coronary Events Score and Complications Following Acute Myocardial
           Infarction During 1-Year Follow-Up

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      Authors: Yuhan Qin, Yong Qiao, Dong Wang, Chengchun Tang, Gaoliang Yan
      Abstract: Angiology, Ahead of Print.
      We explored the effect of admission hyperglycemia (AH) on the Global Registry of Acute Coronary Events (GRACE) risk score and major adverse cardiovascular and cerebrovascular event (MACCE) incidence during 1-year follow-up in acute myocardial infarction (AMI) patients. In this retrospective observational study enrolling 1098 AMI patients, hyperglycemia was defined as blood glucose level ≥180 mg/dl at admission. Overall, 158 and 84 patients of 272 diabetic and 826 non-diabetic patients were diagnosed with AH, respectively. Glucose levels at admission were closely associated with the GRACE score in patients with/without diabetes. MACCEs occurred in 222 patients; patients with AH showed significantly higher MACCE incidence (28.1%). Multivariate Cox logistic regression analysis indicated that AH was an independent risk factor for 1-year MACCEs. Subgroup analysis demonstrated that hyperglycemia increases MACCE risk in non-diabetic patients but not in diabetic patients. The admission glucose level combined with GRACE risk score showed a certain predictive value for MACCE incidence according to ROC analysis (OR = 0.798, p < .001). AH was strongly associated with a higher GRACE risk score in ST-segment elevation myocardial infarction patients. Thus, AH was an independent risk factor and had a high predictive value for MACCE during 1-year follow-up after AMI.
      Citation: Angiology
      PubDate: 2021-08-24T10:34:09Z
      DOI: 10.1177/00033197211039915
       
  • CHA2DS2-VASc-HSF Score may Better Predict the Development of Total
           Coronary Artery Occlusion in Acute Coronary Syndrome

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      Authors: Sara C. Sanlialp, Musa Sanlialp, Serdar Guler
      Abstract: Angiology, Ahead of Print.

      Citation: Angiology
      PubDate: 2021-08-19T10:30:38Z
      DOI: 10.1177/00033197211040348
       
  • Indicators of Amputation in Patients With Critical Limb Ischemia

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      Authors: Yusuf Ata, Derih Ay, Mesut Engin, Ufuk Aydin, Tamer Turk
      Abstract: Angiology, Ahead of Print.

      Citation: Angiology
      PubDate: 2021-08-07T11:52:32Z
      DOI: 10.1177/00033197211037890
       
  • Assessment of Association Between Venous Occlusion and Infection of
           Cardiac Implantable Electronic Devices

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      Authors: Andreas Keyser, Carsten Jungbauer, Janine Rennert, Birgit Linnemann, Christof Schmid, Simon Schopka
      Abstract: Angiology, Ahead of Print.
      The increasing number of patients treated with cardiac implantable electronic devices (CIEDs) and indications for complex pacing requires system revisions. Currently, data on venous patency in repeat CIED surgery involving lead (re)placement or extraction are largely missing. This study aimed to assess venous patency and risk factors in patients referred for repeat CIED lead surgery, emphasizing CIED infection. All consecutive patients requiring extraction, exchange, or additional placement of ≥1 CIED leads during reoperative procedures from January 2015 to March 2020 were evaluated in this retrospective study. Venography was performed in 475 patients. Venous patency could be assessed in 387 patients (81.5%). CIED infection with venous occlusion was detected in 74 patients compared with venous occlusion without infection in 14 patients (P < .05). Concerning venous patency, novel oral anticoagulant medication appeared to be protective (P < .05; odds ratio [OR]: .35). Infection of the CIED appeared to be strongly associated with venous occlusion (OR: 16.0). The sensitivity was only 64.15%, but the specificity was 96.1%. Number of leads involved and previous CIED procedures were not associated with venous occlusion. In conclusion, in patients with CIED, venous occlusion was strongly associated with device infection, but not with the number of leads or previous CIED procedures.
      Citation: Angiology
      PubDate: 2021-08-07T04:18:24Z
      DOI: 10.1177/00033197211038376
       
  • Characteristics, Management, and Prognosis of Spontaneous Coronary
           Intramural Hematoma

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      Authors: Shufu Chang, Yuxiang Dai, Xiaoyue Song, Chenguang Li, Hao Lu, Zheyong Huang, Jianying Ma, Juying Qian, Junbo Ge
      Abstract: Angiology, Ahead of Print.
      Spontaneous coronary intramural hematoma (SCIH) was one type of spontaneous coronary artery dissection without obvious intimal tear, which is easy to misdiagnose. We aimed to study the characteristics, management, and prognosis of SCIH in our center. All the SCIH patients (n = 30) diagnosed by coronary angiography from January 1, 2012 to December 31, 2018 were enrolled. The demographic characteristics, history, therapy, and follow-up were collected. The mean age of the patients was 51.8 ± 9.5 years. Most of the patients were females (66.7%) with hypertension. Patients with diffuse lesion, focal lesion, and multiple vessels were 70%, 13.3%, and 16.7%, respectively. Conservative treatment was the first choice (76.7%). The mean follow-up time was 29.3 ± 13.5 months. None of the patients had unplanned readmission due to worsening symptoms. Nine patients underwent coronary artery computed tomography reexamination after 10.3 ± 7.5 months, which showed complete recovery of SCIH. Eight patients were hospitalized for coronary angiography 6.4 ± 4.7 months later, which did not show any sign of SCIH. Spontaneous coronary intramural hematoma was most common in post-menopausal women with hypertension. Possibly, antiplatelet drugs should be avoided in SCIH. Waiting for the hematoma to heal was preferable and had a good prognosis.
      Citation: Angiology
      PubDate: 2021-08-04T08:01:16Z
      DOI: 10.1177/00033197211036220
       
  • Biomarkers of Coronary Microvascular Dysfunction in Patients With
           Microvascular Angina: A Narrative Review

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      Authors: Vincenzo Sucato, Egle Corrado, Girolamo Manno, Francesco Amata, Gabriella Testa, Giuseppina Novo, Alfredo R Galassi
      Abstract: Angiology, Ahead of Print.
      The current gold standard for diagnosis of coronary microvascular dysfunction (CMD) in the absence of myocardial diseases, whose clinical manifestation is microvascular angina (MVA), is reactivity testing using adenosine or acetylcholine during coronary angiography. This invasive test can be difficult to perform, expensive, and harmful. The identification of easily obtainable blood biomarkers which reflect the pathophysiology of CMD, characterized by high reliability, precision, accuracy, and accessibility may reduce risks and costs related to invasive procedures and even facilitate the screening and diagnosis of CMD. In this review, we summarized the results of several studies that have investigated the possible relationships between blood biomarkers involved with CMD and MVA. More specifically, we have divided the analyzed biomarkers into 3 different groups, according to the main mechanisms underlying CMD: biomarkers of “endothelial dysfunction,” “vascular inflammation,” and “oxidative stress.” Finally, in the last section of the review, we consider mixed mechanisms and biomarkers which are not included in the 3 major categories mentioned above, but could be involved in the pathogenesis of CMD.
      Citation: Angiology
      PubDate: 2021-08-02T02:22:36Z
      DOI: 10.1177/00033197211034267
       
  • Associations of Circulating microRNA-221 and 222 With the Severity of
           Coronary Artery Lesions in Acute Coronary Syndrome Patients

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      Authors: Xin Yu, Jian-feng Xu, Ming Song, Lei Zhang, Yi-hui Li, Lu Han, Meng-xiong Tang, Wei Zhang, Ming Zhong, Zhi-hao Wang
      Abstract: Angiology, Ahead of Print.
      Circulating levels of microRNA-221 and 222 (miR-221/222) in patients with coronary artery disease (CAD) are elevated, yet the relationship between circulating miR-221/222 and the severity of coronary lesions in patients with acute coronary syndrome (ACS) remains unknown. In this study, the relative expression levels of circulating miR-221/222 in patients with ACS (n = 267) and controls (n = 71) were compared by real-time fluorescence quantitative-polymerase chain reaction (RT-qPCR). The ACS group was further divided into unstable angina pectoris (UA) group (n = 191) and acute myocardial infarction (AMI) group (n = 76). Significant upregulation of circulating miR-221/222 was observed in ACS. A positive linear correlation between circulating miR-221/222 and Gensini scores was demonstrated. The area under the curve (AUC) of circulating miR-221/222 in the diagnosis of coronary artery stenosis ≥50% was 0.605 and 0.643, respectively. The circulating miRNA-221/222 expression levels in ACS patients were elevated and positively associated with the severity of the coronary artery lesions. Circulating miR-221/222 may be novel biomarkers for the diagnosis of coronary artery stenosis ≥50% and the occurrence of ACS.
      Citation: Angiology
      PubDate: 2021-07-31T01:28:33Z
      DOI: 10.1177/00033197211034286
       
  • Plasma Leukocyte Cell-Derived Chemotaxin 2 (LECT2) as a Risk Factor of
           Coronary Artery Disease: A Cross-Sectional Study

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      Authors: Mengqiu Wei, Jun Liu, Hailin Pan, Ziting Zhou, Kai Guo
      Abstract: Angiology, Ahead of Print.
      Many studies have shown that leukocyte cell-derived chemotaxin 2 (LECT2) is associated with metabolic disorders, which is a risk factor of arteriosclerosis. We assessed the level of LECT-2 in patients with coronary artery disease (CAD) and its severity and prognosis. We selected 666 participants who underwent coronary angiography in our hospital and included patients with non-CAD, patients with stable angina pectoris (SAP), patients with unstable angina (UA), patients with non-ST-segment elevation myocardial infarction (NSTEMI) and patients with ST-segment elevation myocardial infarction (STEMI). The serum level of LECT-2 was higher in patients with CAD than in patients with non-CAD and was an independent predictor for CAD. Subgroup analysis showed that compared with the SAP group, the UA, NSTEMI, and STEMI groups had higher serum levels of LECT-2. In addition, the level of LECT-2 was related to the SYNTAX score and SYNTAX II score. Finally, patients with acute myocardial infarction (AMI) with elevated levels of LECT-2 had a higher risk of major adverse cardiovascular events (MACEs) within 12 months than those with lower levels of LECT-2. Plasma LECT-2 levels may be useful for the diagnosis of CAD and as predictors of MACE in patients with AMI.
      Citation: Angiology
      PubDate: 2021-07-28T09:12:46Z
      DOI: 10.1177/00033197211028023
       
  • Angiographic and Clinical Profile of Patients With COVID-19 Referred for
           Coronary Angiography During SARS-CoV-2 Outbreak: Results From a
           Collaborative, European, Multicenter Registry

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      Authors: J.M. Montero-Cabezas, J.G. Córdoba-Soriano, F. Díez-Delhoyo, J. Abellán-Huerta, H. Girgis, J.C. Rama-Merchán, S. García-Blas, J.B. van Rees, J. van Ramshorst, A. Jurado-Román
      Abstract: Angiology, Ahead of Print.
      Data regarding angiographic characteristics, clinical profile, and inhospital outcomes of patients with coronavirus disease 2019 (COVID-19) referred for coronary angiography (CAG) are scarce. This is an observational study analyzing confirmed patients with COVID-19 referred for CAG from 10 European centers. We included 57 patients (mean age: 66 ± 15 years, 82% male) , of whom 18% had previous myocardial infarction (MI) and 29% had renal insufficiency and chronic pulmonary disease. ST-segment elevation myocardial infarction (STEMI) was the most frequent indication for CAG (58%). Coronavirus disease 2019 was confirmed after CAG in 86% and classified as mild in 49%, with 21% fully asymptomatic. A culprit lesion was identified in 79% and high thrombus burden in 42%; 7% had stent thrombosis. At 40 days follow-up, 16 (28%) patients experienced a major adverse cardiovascular event (MACE): 12 deaths (92% noncardiac), 1 MI, 2 stent thrombosis, and 1 stroke. In an European multicenter registry, patients with confirmed COVID-19 infection referred for CAG during the first wave of the severe acute respiratory syndrome coronavirus 2 pandemic presented mostly with STEMI and were predominantly males with comorbidities. Severity of COVID-19 was in general noncritical and 21% were asymptomatic at the time of CAG. Culprit coronary lesions with high thrombus burden were frequently identified, with a rate of stent thrombosis of 7%. The incidence of MACE at 40 days was high (28%), mostly due to noncardiac death.
      Citation: Angiology
      PubDate: 2021-07-28T09:11:32Z
      DOI: 10.1177/00033197211028760
       
  • Venous Thromboembolism and Critical Limb Events in Patients with Atrial
           Fibrillation: A Nationwide Population-Based Cohort Study

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      Authors: Ming-Shyan Lin, Chang-Min Chung, Mei-Yen Chen, Pao-Hsien Chu, Shih-Tai Chang, Teng-Yao Yang, Victor C-C Wu, Wey-Yil Lin, Yu-Sheng Lin
      Abstract: Angiology, Ahead of Print.
      Little is known about whether venous thromboembolism (VTE) causes worse critical limb events in populations with atrial fibrillation (AF). A retrospective cohort study using claims data from Taiwan’s National Health Insurance program between 2001 and 2013 compared AF patients with or without VTE. Outcomes were percutaneous transluminal angioplasty (PTA), amputation, systemic thromboembolism, all-cause mortality, cardiovascular death, ischemic stroke, and acute myocardial infarction. Patients (n = 316,817) with newly diagnosed AF were analyzed; of those, 2514 (0.79%) had VTE history. After inverse probability of treatment weighting, a history of VTE was significantly associated with higher risks of PTA (3.3 vs 2.2%; subdistribution hazard ratio [SHR] 1.47; 95% confidence interval [CI] 1.17–1.84); above knee amputation (0.7 vs 0.3%; HR 2.15; 95% CI 1.10–4.21); systemic thromboembolism (5.8 vs 3.9%; SHR 1.48; 95% CI 1.21–1.80); all-cause mortality (53 vs 46.4%; HR 1.20, 95% CI 1.12–1.29); and cardiovascular death (34.8 vs 29.4%; HR 1.25, 95% CI 1.14–1.36). In conclusion, VTE might increase the risk of critical lower limb events (PTA and above-knee amputation), systemic thromboembolism, and mortality in the AF population. However, current data cannot confirm a causal relationship between VTE and clinical outcomes in this population.
      Citation: Angiology
      PubDate: 2021-07-21T03:10:24Z
      DOI: 10.1177/00033197211033747
       
  • The CHA2DS2-VASc Risk Score Predicts Total Occlusion in Infarct-Related
           Arteries in Patients With Non-ST Elevation Myocardial Infarction

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      Authors: Erdoğan Yaşar, Adil Bayramoğlu, Yasin Karakuş, Tolga Çakmak
      Abstract: Angiology, Ahead of Print.
      Early detection of total coronary artery occlusion (TO) in non-ST elevation myocardial infarction (NSTEMI) patients may be beneficial since invasive treatments are initiated more rapidly in appropriate patients. Previous studies have shown that the CHA2DS2-VASc (congestive heart failure, hypertension, age ≥75 years, diabetes mellitus, previous stroke, vascular disease, age between 65 and 74 years, female gender) score is associated with thrombus burden in acute coronary syndromes. We investigated the association between the CHA2DS2-VASc risk score and TO in patients with NSTEMI who underwent coronary angiography. TIMI (thrombolysis in myocardial infarction) flow 0 was defined as TO and TIMI flow 1-3 was defined as non-total occlusion (non-TO). The NSTEMI patients (n = 400) included were separated into two groups: those with (n = 138) and without (n = 262) TO. We observed that the CHA2DS2-VASc score was higher in the TO group (3.86 ± 2.32 vs 2.15 ± 1.79, P
      Citation: Angiology
      PubDate: 2021-07-17T03:14:16Z
      DOI: 10.1177/00033197211031324
       
  • The Association Between Serum Endocan Level and Short-Term Prognosis of
           Patients With Acute Ischemic Stroke

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      Authors: Feng Han, Weifang Liao, Xunxin Duan, Yuying Shi, Zhijian Hu
      Abstract: Angiology, Ahead of Print.
      This cohort study was designed to assess the association between serum endocan levels and the prognosis of acute ischemic stroke. A total of 227 patients were recruited consecutively. Study outcome data on death and major disability (modified Rankin Scale score ≥3) were collected at 3 months after stroke onset. After 3 months of follow-up, death and disability occurred in 48 and 85 patients, respectively, while the primary (death) and secondary (death or disability) outcome incident rate was 21.15% and 37.44%, respectively. The multivariable adjusted odds ratio (OR) (95% confidence interval, 95% CIs) of the highest endocan quartile for death or major disability was 1.21 (1.10, 4.13) compared with the lowest quartile. After adjusting for confounding factors, the increase in the risk of death was not significant. Receiver operating characteristic curve analysis showed that endocan predicted primary and secondary outcomes with C-statistical values (95% CIs) of 0.61 (0.55–0.67, P = .001) and 0.68 (0.59–0.76, P < .001), respectively. Elevated endocan levels were independently related to increased risk of poor outcome at 3 months after ischemic stroke onset. Endocan is a potential prognostic factor for ischemic stroke.
      Citation: Angiology
      PubDate: 2021-07-16T11:42:59Z
      DOI: 10.1177/00033197211030732
       
  • Promising Parameters in Predicting High SYNTAX II Score and In-Hospital
           Mortality for Non-ST-Elevation Myocardial Infarction

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      Authors: Mehmet Kadri Akboga, Ibrahim Halil Inanc, Ridvan Yalcin
      Abstract: Angiology, Ahead of Print.

      Citation: Angiology
      PubDate: 2021-07-16T09:08:57Z
      DOI: 10.1177/00033197211026047
       
  • Impact of Hypertension on the Prognosis of COVID-19 Disease and
           Uncertainties that Need to be Clarified

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      Authors: Sara Cetin Sanlialp, Musa Sanlialp
      Abstract: Angiology, Ahead of Print.

      Citation: Angiology
      PubDate: 2021-07-15T05:22:40Z
      DOI: 10.1177/00033197211032784
       
  • High-Sensitivity Cardiac Troponin T Assessment to Improve Cardiovascular
           Risk Prognostication in Patients with Chronic Kidney Disease: Ready for
           Prime Time'

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      Authors: Panagiotis I. Georgianos, Vassilios Liakopoulos
      Abstract: Angiology, Ahead of Print.

      Citation: Angiology
      PubDate: 2021-07-14T10:52:11Z
      DOI: 10.1177/00033197211032776
       
  • C-Reactive Protein/Albumin Ratio Predicts Acute Kidney Injury in Patients
           With Moderate to Severe Chronic Kidney Disease and Non-ST-Segment
           Elevation Myocardial Infarction

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      Authors: Baris Simsek, Tufan Cinar, Duygu Inan, Kazim Serhan Ozhan, Sena Sert Sekerci, Veysel Ozan Tanık, Gonul Zeren, Ilhan Ilker Avci, Ümit Yaşar Sinan, Baris Gungor, Can Yucel Karabay
      Abstract: Angiology, Ahead of Print.
      In this study, we aimed to evaluate the predictive value of admission C-reactive protein/albumin ratio (CAR) for acute kidney injury (AKI) in cases with moderate to severe chronic kidney disease (CKD) not on dialysis who presented with non-ST-segment elevation myocardial infarction (NSTEMI) and underwent coronary angiography (CAG). This cross-sectional and observational study included 420 NSTEMI patients. The study population was categorized based on the CAR tertiles as groups T1, T2, and T3. The primary outcome of the study was AKI development; 92 (21.9%) cases developed AKI. The frequency of AKI was significantly higher in the T3 group compared with the T2 and T1 groups (34% vs 17% vs 14%, P < .001). Age, estimated glomerular filtration rate, contrast media volume, and CAR (odds ratio: 1.36; 95% CI: 1.17-1.57; P < .01) were significant predictors of AKI. In a receiver operating characteristic curve analysis, CAR levels >0.20 predicted AKI development with a sensitivity of 74% and a specificity of 45%. We observed that the CAR may be a promising inflammatory parameter for AKI in NSTEMI patients with moderate to severe CKD after CAG.
      Citation: Angiology
      PubDate: 2021-07-14T09:03:35Z
      DOI: 10.1177/00033197211029093
       
  • Systemic Immune-Inflammation Index May Predict the Development of
           Contrast-Induced Nephropathy in Patients With ST-Segment Elevation
           Myocardial Infarction

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      Authors: Ali Bağcı, Fatih Aksoy, Hasan Aydin Baş
      Abstract: Angiology, Ahead of Print.
      The aim of this study was to investigate the predictive capacity of a systemic immune-inflammation index (SII) in the detection of contrast-induced nephropathy (CIN) following ST-segment elevation myocardial infarction (STEMI). A total of 477 STEMI patients were enrolled in the study. The patients were divided into 2 groups according to CIN development. A cutoff point of 5.91 for logarithm-transformed SII was identified with 73.0% sensitivity and 57.5% specificity to predict CIN following STEMI. According to a pairwise analysis of receiver operating characteristic curve analysis, the predictive power of SII in detecting CIN following STEMI was similar to that of high-sensitivity C-reactive protein and better than the neutrophil/lymphocyte ratio or platelet/lymphocyte ratio. As a result, SII can be used as one of the independent predictors of CIN after STEMI.
      Citation: Angiology
      PubDate: 2021-07-12T08:56:54Z
      DOI: 10.1177/00033197211030053
       
  • Baseline Anemia Is an Independent Predictor of Long-Term Mortality in
           Patients Undergoing Transcatheter Aortic Valve Implantation

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      Authors: Serdal Baştuğ, Cem Çöteli, Muhammet Cihat Çelik, Haci Ahmet Kasapkara, Nihal Akar Bayram, Murat Akcay, Tahir Durmaz
      Abstract: Angiology, Ahead of Print.
      This study aimed to investigate the relationship between baseline anemia and long-term mortality in a single-center retrospective study involving patients undergoing transcatheter aortic valve implantation (TAVI). The study population included 412 consecutive patients undergoing TAVI at a center for severe aortic valve stenosis between August 2011 and November 2018. The primary end point of the study was all-cause mortality. Baseline anemia was present in 50% of our study cohort. During the median follow-up of 29 months, all-cause mortality was observed in 40.3% of the whole study population and was more frequently observed in the anemic group compared with the nonanemic group (53.5% vs 27.1%, P < .001, respectively). Cox-regression analysis revealed that Society of Thoracic Surgeons Predicted Risk of Mortality score, previous stroke, pericardial tamponade, and neutrophil–lymphocyte ratio count are independent predictors of long-term mortality after TAVI. Additionally, the presence of anemia at baseline was an independent predictor of long-term mortality with a 2.3-fold difference in the anemic group compared with the nonanemic group (hazard ratio: 2.31, 95% CI: 1.59-3.37, P < .001). Baseline anemia was observed in half of our patient population undergoing TAVI, and baseline anemia was found to be an independent predictor of long-term mortality after TAVI.
      Citation: Angiology
      PubDate: 2021-07-12T08:55:54Z
      DOI: 10.1177/00033197211029801
       
  • The Association Between Cardio-Ankle Vascular Index and Primary Idiopathic
           Complete Atrioventricular Block in an Elderly Population

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      Authors: Turhan Turan, Faruk Kara, Selim Kul, Muhammet Rasit Sayın, Sinan Sahin, Mustafa Oğuz Varol, Ali Riza Akyuz, Ali Bayraktar, Ömer Faruk Çırakoğlu, Levent Korkmaz
      Abstract: Angiology, Ahead of Print.
      The most common cause of complete atrioventricular block (CAVB) is age-related fibrotic degeneration and is referred to as primary idiopathic complete atrioventricular block (iCAVB). This study aims to investigate the relationship between iCAVB and arterial stiffness using the cardio-ankle vascular index (CAVI).In this study, of 205 CAVB patients, 41 patients with iCAVB implanted with a dual-chamber permanent pacemaker and 40 age- and gender-matched controls were studied. Arterial stiffness was assessed by a VaSera VS-1000 CAVI instrument. The CAVI values of patients with iCAVB were significantly higher compared with the controls (9.63 ± 1.42 vs 8.57 ± 1.12, P < .001). Idiopathic complete atrioventricular block frequency was higher among patients with abnormal CAVI values than those with borderline and normal CAVI (P = .04). In multivariate analysis, only CAVI was an independent predictor of iCAVB after adjusting for other relevant factors (odds ratio, 2.575; 95% CI [1.390-4.770]; P = .003). The present study demonstrated that CAVI, as a marker of arterial stiffness, was increased among elderly patients with iCAVB. Thus, we provide a possible additional mechanism linking easily measured CAVI with iCAVB.
      Citation: Angiology
      PubDate: 2021-07-08T09:20:17Z
      DOI: 10.1177/00033197211028780
       
  • Long-Term Follow-Up of Patients With Isolated Side Branch Coronary Artery
           Disease

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      Authors: Sukru Arslan, Ahmet Yildiz, Okay Abaci, Urfan Jafarov, Servet Batit, Onur Kilicarslan, Tugay Yumuk, Omer Dogan, Cuneyt Kocas, Cem Bostan
      Abstract: Angiology, Ahead of Print.
      The data with respect to stable coronary artery disease (SCAD) are mainly confined to main vessel disease. However, there is a lack of information and long-term outcomes regarding isolated side branch disease. This study aimed to evaluate long-term major adverse cardiac and cerebrovascular events (MACCEs) in patients with isolated side branch coronary artery disease (CAD). A total of 437 patients with isolated side branch SCAD were included. After a median follow-up of 38 months, the overall MACCE and all-cause mortality rates were 14.6% and 5.9%, respectively. Among angiographic features, 68.2% of patients had diagonal artery and 82.2% had ostial lesions. In 28.8% of patients, the vessel diameter was ≥2.75 mm. According to the American College of Cardiology lesion classification, 84.2% of patients had either class B or C lesions. Age, ostial lesions, glycated hemoglobin A1c, and neutrophil levels were independent predictors of MACCE. On the other hand, side branch location, vessel diameter, and lesion complexity did not affect outcomes. Clinical risk factors seem to have a greater impact on MACCE rather than lesion morphology. Therefore, the treatment of clinical risk factors is of paramount importance in these patients.
      Citation: Angiology
      PubDate: 2021-07-08T09:19:41Z
      DOI: 10.1177/00033197211028024
       
  • Systemic Immune-Inflammation Index Is a Predictor of Contrast-Induced
           Nephropathy in Patients With ST-Segment Elevation Myocardial Infarction

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      Authors: Recep Öztürk, Duygu İnan, Barış Güngör
      Abstract: Angiology, Ahead of Print.
      We evaluated the predictive value of admission systemic immune-inflammation index (SII) for the risk of contrast-induced nephropathy (CIN) in patients with ST-segment elevation myocardial infarction (STEMI) treated with primary percutaneous coronary intervention (pPCI). The neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and SII (platelet × NLR) levels were calculated in 1621 consecutive patients with STEMI. The relationship of these parameters with CIN development within 72 hours of pPCI was analyzed. Of the study population, 343 (21.1%) cases developed CIN. The frequency of CIN was 11.1% in the first SII quartile, 11.6% in the second SII quartile, 26.8% in the third SII quartile, and 35% in the fourth SII quartile, which differed significantly between groups (P < .01). Age, baseline glomerular filtration rate, contrast media volume, hypertension, C-reactive protein levels, and the quartiles of SII were independent predictors of CIN. Patients in the third SII quartile versus first SII quartile (OR: 2.906, 95% CI, 1.903-4.437; P < .001), and fourth SII quartile versus first SII quartile (OR: 4.168, 95% CI, 2.754-6.313; P < .001) had a significantly higher risk for CIN in the multivariable model. The SII may be a promising inflammatory parameter to predict CIN after pPCI.
      Citation: Angiology
      PubDate: 2021-07-07T09:27:48Z
      DOI: 10.1177/00033197211029094
       
  • Does Sex Influence Outcomes in Myocardial Infarction With Nonobstructive
           Coronary Arteries'

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      Authors: Abdul-Quddus Mohammed, Fuad A. Abdu, Lu Liu, Guoqing Yin, Bin Xu, Siling Xu, Cailin Feng, Xian Lv, Rui Fan, Wenliang Che, Yawei Xu
      Abstract: Angiology, Ahead of Print.
      We examined differences in clinical profiles, predictors, and outcomes among patients with myocardial infarction (MI) with nonobstructive coronary arteries (MINOCAs) by sex. Data of 259 (132 males and 127 females) patients with MINOCA were consecutively collected. The primary clinical end point was major adverse cardiovascular events (MACE), including cardiovascular death, nonfatal MI, stroke, heart failure, and angina rehospitalization. Female patients with MINOCA were likely to be older than male patients with higher non-ST elevation myocardial infarction rate. Total cholesterol, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol levels were higher in female patients while male patients were more likely to have a smoking history, greater ST elevation myocardial infarction rate, higher diastolic blood pressure, and more alcohol use. During the 2-year follow-up, the incidence of MACE in males and females was similar (18% vs 20.2%, respectively; P = .673). The multivariable predictors of MACE in the female group were age, hypertension, and left ventricular ejection fraction (LVEF), whereas diabetes, smoking, and LVEF were multivariable predictors of MACE in the male group. In conclusion, there were differences in the clinical profiles between sexes. Clinical outcome was similar between male and female patients with MINOCA, whereas predictive risk factors varied.
      Citation: Angiology
      PubDate: 2021-07-07T09:27:12Z
      DOI: 10.1177/00033197211028428
       
  • Identifying the Vulnerable Carotid Atherosclerotic Plaque in Patients With
           Asymptomatic Carotid Stenosis

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      Authors: Kosmas I. Paraskevas, Andrew N. Nicolaides, Jasjit S. Suri, Luca Saba
      Abstract: Angiology, Ahead of Print.

      Citation: Angiology
      PubDate: 2021-07-02T09:08:57Z
      DOI: 10.1177/00033197211028416
       
  • Effects of Pacemaker Implantation on Sudden Cardiac Death Rate and Quality
           of Life in Atrial Fibrillation Patients With Ventricular Pauses

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      Authors: Yao-Dong Li, Yi-Fan Hong, Jian-Hua Ma, Gui-Qiu Cao, Xian-Hui Zhou, Jiang-Hua Zhang, Qiang Xing, Bao-Peng Tang
      Abstract: Angiology, Ahead of Print.
      Ventricular arrest is a rare arrhythmic disease in the clinic; 35% to 55% of cases are associated with atrial fibrillation (AF). It is well known that ventricular arrest for ≥3 seconds can lead to brain symptoms such as dizziness and even syncope, but it is not clear whether ventricular pauses (≥3 seconds) with AF will lead to sudden cardiac death. If the implantation of a pacemaker can improve the quality of life of patients with permanent AF with ventricular arrest and whether it has a long-term protective effect on sudden cardiac death. To this end, we conducted a prospective follow-up observation study, which was conducted through telephone interviews and clinical hospital observation to obtain information on the quality of life, survival rate, and other details. The results show that for patients with permanent AF with ventricular arrest, pacemaker implantation cannot reduce sudden cardiac death, cardiovascular events, and stroke nor can it improve the cumulative survival rate. Fortunately, the implantation of pacemakers can improve the quality of life of patients.
      Citation: Angiology
      PubDate: 2021-07-02T09:08:19Z
      DOI: 10.1177/00033197211028022
       
  • Points to Be Resolved Regarding the Use of the Triglyceride Glucose Index
           for Cardiovascular Disease

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      Authors: Sara Cetin Sanlialp
      Abstract: Angiology, Ahead of Print.

      Citation: Angiology
      PubDate: 2021-06-30T09:38:46Z
      DOI: 10.1177/00033197211028429
       
  • The ATRIA and Modified-ATRIA Scores in Evaluating the Risk of No-Reflow in
           

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      Authors: Ozge Ozcan Abacioglu, Arafat Yildirim, Nermin Yildiz Koyunsever, Salih Kilic
      Abstract: Angiology, Ahead of Print.
      The no-reflow (NR) phenomenon is frequently encountered in acute coronary syndrome. We evaluated the association between anticoagulation and risk factors in atrial fibrillation (ATRIA) and modified ATRIA risk scores and NR in ST-elevation myocardial infarction (STEMI). Consecutive patients (n = 551) who underwent primary percutaneous coronary intervention between December 2019 and June 2020 due to STEMI were included. The mean age of the patients was 60.5 ± 10.8 years (n = 369, 67% male). The ATRIA and modified anticoagulation and risk factors in atrial fibrillation-hyperlipidemia, smoking, male (m-ATRIA-HS) scores were calculated. The NR group had higher frequency of diabetes mellitus (DM), serum creatine kinase-MB (CK-MB) levels, and corrected thrombolysis in myocardial infarction frame count (cTFC) (P = .002, P = .006, and P < .001, respectively). In regression analysis, ATRIA, m-ATRIA-HS, thrombus grade, and cTFC were independent predictors of NR. Age, higher CK-MB, and neutrophil-to-lymphocyte ratio and DM were the other predictors for NR. Pairwise comparison of receiver operating characteristics curve analysis showed that the m-ATRIA-HS (>2, area under curve [AUC]: 0.715) has better performance than ATRIA score (>1, AUC: 0.656), with a P < .022 and z statistics 2.279. In conclusion, ATRIA, especially the m-ATRIA-HS, can be used to evaluate NR risk in STEMI.
      Citation: Angiology
      PubDate: 2021-06-28T11:13:53Z
      DOI: 10.1177/00033197211026420
       
  • Diagnostic and Prognostic Value of Serum Endocan Levels in Patients With
           COVID-19

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      Authors: Selim Görgün, Şener Cindoruk, Emre Özgen, Metin Yadigaroğlu, Mehmet Tevfik Demir, Murat Yücel, Çetin Kürşad Akpınar, Murat Güzel
      Abstract: Angiology, Ahead of Print.
      We aimed to evaluate whether there was a relationship between endocan (human endothelial cell-specific molecule-1) levels and disease prognosis in patients who presented to the emergency department with coronavirus disease 2019 (COVID-19). A total of 60 patients with COVID-19 who were hospitalized from the emergency department to clinical wards and a control group consisting of healthy adult individuals (n = 28), were included in the study. The majority (93.3%) of the patients were discharged after recovery; 6.7% died. The median endocan value was 243.5 ng/mL in the patient group versus 201.5 ng/mL in the control group (P = .002). The median endocan level was 240.5 ng/mL in those discharged with recovery and 558 ng/mL in those who died (P = .001). There was no significant relationship in hospitalization duration, sex, tomography findings, and clinical outcomes. A 202 ng/mL serum endocan level had 86.7% sensitivity and 50% specificity for COVID-19. Serum endocan levels may be a useful biomarker both for the diagnosis of COVID-19 and to predict mortality.
      Citation: Angiology
      PubDate: 2021-06-28T09:45:50Z
      DOI: 10.1177/00033197211026044
       
  • Association Between White Blood Cell Counts and Brachial-Ankle Pulse Wave
           Velocity in Chinese Hypertensive Adults: A Cross-Sectional Study

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      Authors: Buyun Jia, Chongfei Jiang, Yun Song, Chenfangyuan Duan, Lishun Liu, Chengzhang Liu, Xiping Xu, Xianhui Qin, Guangliang Chen
      Abstract: Angiology, Ahead of Print.
      Increased arterial stiffness is highly prevalent in patients with hypertension and is associated with cardiovascular (CV) risk. Increased white blood cell (WBC) counts may also be an independent risk factor for arterial stiffness and CV events. The aim of the study was to investigate the relationship between differential WBC counts and brachial-ankle pulse wave velocity (baPWV) in hypertensive adults. A total of 14 390 participants were included in the final analysis. A multivariate linear regression model was applied for the correlation analysis of WBC count and baPWV. Higher WBC counts were associated with a greater baPWV: adjusted β = 10 (95% CI, 8-13, P < .001). The same significant association was also found when WBC count was assessed as categories or quartiles. In addition, the effect of differential WBC subtypes, including neutrophil count and lymphocyte count on baPWV, showed the similar results. These findings showed that baPWV has positive associations with differential WBC counts in hypertensive adults.
      Citation: Angiology
      PubDate: 2021-06-24T09:03:21Z
      DOI: 10.1177/00033197211021199
       
  • Should We Use Fasting Glucose and the Glycated Hemoglobin (HbA1c) in
           Evaluation of Coronary Artery Disease'

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      Authors: Sara Cetin Sanlialp, Musa Sanlialp
      Abstract: Angiology, Ahead of Print.

      Citation: Angiology
      PubDate: 2021-06-18T10:15:19Z
      DOI: 10.1177/00033197211026418
       
  • Relationship Between C-Reactive Protein to Albumin Ratio and
           Infarct-Related Artery Patency in Patients With ST-Segment Elevation
           Myocardial Infarction

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      Authors: Kadriye Gayretli Yayla, Cagri Yayla, Mehmet Akif Erdol, Mustafa Karanfil, Ahmet Goktug Ertem, Adnan Burak Akcay
      Abstract: Angiology, Ahead of Print.
      The C-reactive protein to albumin ratio (CAR) is a predictive marker of systemic inflammatory state in atherosclerotic coronary disease when compared with the predictive value of these 2 markers separately. We investigated the relationship between CAR and infarct-related artery (IRA) patency in patients with ST-segment elevation myocardial infarction (STEMI). The study population (n = 1047) was divided into 2 groups according to IRA patency which was assessed by the Thrombolysis in Myocardial Infarction (TIMI) flow grade. Nonpatent flow was defined as TIMI grade 0 (no-reflow), 1, and 2 flows, and normal flow was defined as TIMI 3 flow. There was a significant positive correlation between CAR and SYNTAX score (r = 0.312, P < .001) and a negative correlation between CAR and TIMI grade flow (r = −0.210, P < .001). At a cutoff level of 0.693, the CAR predicted TIMI no-reflow with a sensitivity of 65.4% and a specificity of 65.5% (area under the curve: 0.670, 95% CI: 0.62-0.71, P < .001). Multivariate logistic regression analyses showed that CAR was an independent predictor of IRA patency (0.003 [0.001-0.029]; P < .001). A higher CAR is a significant and independent predictor of IRA patency in patients with STEMI.
      Citation: Angiology
      PubDate: 2021-06-16T09:52:17Z
      DOI: 10.1177/00033197211024047
       
  • Relationship Between High-Sensitivity C-Reactive Protein and Long-Term
           Outcomes in Elderly Patients With 3-Vessel Disease

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      Authors: Yue Liu, Ce Zhang, Lin Jiang, Lianjun Xu, Jian Tian, Xueyan Zhao, Xinxing Feng, Dong Wang, Yin Zhang, Kai Sun, Jingjing Xu, Ru Liu, Bo Xu, Wei Zhao, Rutai Hui, Runlin Gao, Zhan Gao, Lei Song, Jinqing Yuan
      Abstract: Angiology, Ahead of Print.
      The prognostic value of high-sensitivity C-reactive protein (hsCRP) in complex coronary artery disease has not been fully established. We aimed to determine the association between hsCRP and long-term outcomes in elderly patients with 3-vessel disease (TVD). From April 2004 to February 2011, 3069 patients aged ≥65 years with TVD were consecutively enrolled and received medical treatment alone, percutaneous coronary intervention, or coronary artery bypass grafting. The patients were divided into 2 groups according to their hsCRP levels:
      Citation: Angiology
      PubDate: 2021-06-10T09:36:39Z
      DOI: 10.1177/00033197211021195
       
  • The Preventive Effect of Alprostadil on the Contrast-Induced Nephropathy
           of Coronary Heart Disease Treated by Percutaneous Coronary Intervention in
           Moderate and High-Risk Population Stratified by Mehran Score

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      Authors: Xiaogang Liu, Peng Zhang, Jing Zhang, Xue Zhang, Shicheng Yang, Naikuan Fu
      Abstract: Angiology, Ahead of Print.
      The Mehran risk score (MRS) was used to classify patients with coronary heart disease and evaluate the preventive effect of alprostadil on contrast-induced nephropathy (CIN) after percutaneous coronary intervention. The patients (n = 1146) were randomized into an alprostadil and control group and then divided into 3 groups on the basis of the MRS: low-risk, moderate-risk, and high-risk groups. The primary end point was the occurrence of CIN (alprostadil + hydration vs simple hydration treatment); secondary end points included serum creatinine, blood urea nitrogen, creatinine clearance rate, cystatin C, interleukin-6, C-reactive protein, proteinuria, and differences in the incidence of major adverse events. In the low-risk, moderate-risk, and high-risk groups, the incidence of CIN in the control and alprostadil group was 2.9 versus 2.6% (P = .832), 11.4 versus 4.9% (P = .030), 19.1 versus 7.7% (P = .041), respectively. Multivariate logistic regression analysis showed that alprostadil treatment was a favorable protective factor for moderate-risk and high-risk CIN patients (OR = 0.343, 95% CI: 0.124-0.951, P = .040). Alprostadil can be used as a preventive treatment for moderate- and high-risk CIN patients classified by the MRS. The reduction of CIN by alprostadil may be related to an anti-inflammatory effect.
      Citation: Angiology
      PubDate: 2021-06-08T08:39:35Z
      DOI: 10.1177/00033197211015540
       
  • Genome-Wide Association Studies in Patients With Coronary Artery Disease

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      Authors: Cagri Yayla, Kadriye Gayretli Yayla, Koray Demirtaş
      Abstract: Angiology, Ahead of Print.

      Citation: Angiology
      PubDate: 2021-06-03T09:11:38Z
      DOI: 10.1177/00033197211022076
       
  • Prognostic Value of Baseline d-Dimer Level in Patients With Coronary
           Artery Disease: A Meta-Analysis

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      Authors: Hongliang Zhang, Jing Yao, Zhiwei Huang, Zhenyan Zhao, Bincheng Wang, Jie Zhao
      Abstract: Angiology, Ahead of Print.
      The prognostic significance of d-dimer level in patients with coronary artery disease (CAD) is not fully established. This meta-analysis aimed to examine the association between elevated d-dimer level at baseline and adverse outcomes in patients with CAD. Two independent authors comprehensively searched PubMed and Embase databases from their inception to December 31, 2020. All observational studies reporting the values of baseline d-dimer level in predicting the major adverse cardiovascular events (MACEs) or survival outcomes in patients with CAD were included. The prognostic values were calculated by pooling adjusted RR with 95% CI for the highest versus the lowest d-dimer level. Thirteen studies consisting of 25 600 patients with CAD were identified. Comparison between the highest and lowest d-dimer level showed that the pooled multivariable adjusted RR was 1.69 (95% CI, 1.53-1.86) for all-cause mortality, 2.37 (95% CI, 1.52-3.69) for cardiovascular mortality, and 1.44 (95% CI, 1.19-1.74) for MACEs, respectively. Elevated blood level of d-dimer at baseline was independently associated with higher risk of MACEs, cardiovascular death, and all-cause mortality in patients with CAD. The baseline d-dimer level may have important prognostic value in patients with CAD.
      Citation: Angiology
      PubDate: 2021-06-03T09:00:30Z
      DOI: 10.1177/00033197211019805
       
  • Perivascular Adipose Tissue: Pathophysiological Links With Inflammation,
           Atherosclerosis, and Thrombosis

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      Authors: Niki Katsiki, Dimitri P. Mikhailidis
      Abstract: Angiology, Ahead of Print.

      Citation: Angiology
      PubDate: 2021-05-25T08:35:19Z
      DOI: 10.1177/00033197211014676
       
  • For Prediction of “No-Reflow,” How Precise is
           PRECISE-DAPT'

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      Authors: Adrian W. Messerli, Taha Ahmed
      Abstract: Angiology, Ahead of Print.

      Citation: Angiology
      PubDate: 2021-05-21T09:37:55Z
      DOI: 10.1177/00033197211018356
       
  • Comparing Symptomatic and Asymptomatic Carotid Artery Atherosclerosis in
           Patients With Bilateral Carotid Vulnerable Plaques Using Magnetic
           Resonance Imaging

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      Authors: Ruijing Xin, Dandan Yang, Huimin Xu, Hualu Han, Jin Li, Yingyu Miao, Ziwei Du, Qian Ding, Shasha Deng, Zihan Ning, Rui Shen, Rui Li, Cheng Li, Chun Yuan, Xihai Zhao
      Abstract: Angiology, Ahead of Print.
      We compared plaque characteristics between symptomatic and asymptomatic sides in patients with bilateral carotid vulnerable plaques using magnetic resonance imaging (MRI). Participants (n = 67; mean age: 65.8 ± 7.7 years, 61 males) with bilateral carotid vulnerable plaques were included. Vulnerable plaques were characterized by intraplaque hemorrhage (IPH), large lipid-rich necrotic core (LRNC), or fibrous cap rupture (FCR) on MRI. Symptomatic vulnerable plaques showed greater plaque burden, LRNC volume (median: 221.4 vs 134.8 mm3, P = .003), IPH volume (median: 32.2 vs 22.5 mm3, P = .030), maximum percentage (Max%) LRNC (median: 51.3% vs 41.8%, P = .002), Max%IPH (median: 13.4% vs 9.5%, P = .022), cumulative slices of LRNC (median: 10 vs 8, P = .005), and more juxtaluminal IPH and/or thrombus (29.9% vs 6.0%, P = .001) and FCR (37.3% vs 16.4%, P = .007) than asymptomatic ones. After adjusting for plaque burden, differences in juxtaluminal IPH and/or thrombus (odds ratio [OR]: 5.49, 95% CI: 1.61-18.75, P = .007) and FCR (OR: 2.90, 95% CI: 1.16-7.24, P = .022) between bilateral sides remained statistically significant. For patients with bilateral carotid vulnerable plaques, symptomatic plaques had greater burden, more juxtaluminal IPH and/or thrombus, and FCR compared with asymptomatic ones. The differences in juxtaluminal IPH and/or thrombus and FCR between bilateral sides were independent of plaque burden.
      Citation: Angiology
      PubDate: 2021-05-21T09:14:52Z
      DOI: 10.1177/00033197211012531
       
  • A Possible Case of Hypertensive Crisis With Intracranial Haemorrhage After
           an mRNA Anti-COVID-19 Vaccine

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      Authors: Vasilios G. Athyros, Michael Doumas
      Abstract: Angiology, Ahead of Print.

      Citation: Angiology
      PubDate: 2021-05-21T09:07:57Z
      DOI: 10.1177/00033197211018323
       
  • Aortic Stiffness, Inflammation, and Incidence of Cardiovascular Events in
           Elderly Participants From the General Population

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      Authors: Benjamin Nilsson Wadström, Margaretha Persson, Gunnar Engström, Peter M. Nilsson
      Abstract: Angiology, Ahead of Print.
      Low-grade inflammation and arterial stiffness are key factors in the development of vascular aging. However, the interplay between arterial stiffness and inflammation for cardiovascular (CV) disease is unclear. Aortic pulse wave velocity (aPWV) and the inflammatory markers, high-sensitivity C-reactive protein (CRP) and orosomucoid, were measured in 2710 participants (median age: 72 years). These participants were followed up for a mean of 7.6 years for a composite CV disease end point. Per 1 interquartile range increment of CRP and orosomucoid, respectively, aPWV increased by 0.19 m/s (95% CI: 0.07-0.32) and 0.19 m/s (0.11-0.27), after multifactorial adjustment. Mediation analysis showed that aPWV, after multifactorial adjustment, mediated 8% (−4, 20) of the CV disease risk associated with CRP and 8% (−4, 18) of orosomucoid risk. The associated risk increased with combinations of high aPWV and high CRP or orosomucoid. We found no evidence that arterial PWV acted as an important mediator of the relationship between systemic inflammation and CV disease risk in this elderly population. The results instead indicate an additive effect. Our study supports the view that arterial stiffness and chronic inflammation affects CV risk mainly through separate causal pathways.
      Citation: Angiology
      PubDate: 2021-05-20T09:07:45Z
      DOI: 10.1177/00033197211017406
       
  • Retinal Layer Thickness After Transcatheter Aortic Valve Replacement

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      Authors: Kadriye Gayretli Yayla, Cagri Yayla
      Abstract: Angiology, Ahead of Print.

      Citation: Angiology
      PubDate: 2021-05-13T09:24:46Z
      DOI: 10.1177/00033197211017399
       
  • Predictors of Favorable Angiographic Outcomes After Drug-Coated Balloon
           Use for de novo Small Vessel Coronary Disease (DCB-ONLY)

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      Authors: Woong Chol Kang, Sang Min Park, Albert Youngwoo Jang, Pyung Chun Oh, Eun-Seok Shin, Cheol Woong Yu, Seung-Jin Oh, Yong Hoon Kim, Hoyoun Won, Sang-Rok Lee, Sang Yeub Lee, Young Joon Hong, Sung Yun Lee, Byung Ok Kim, Sang-Wook Kim
      Abstract: Angiology, Ahead of Print.
      We evaluated the angiographic parameter and clinical outcomes of drug-coated balloon (DCB) to assess the optimal angiographic criteria in de novo small vessel disease (SVD). Patients (n = 424, mean age: 64.4 ± 11.2 years, men: 69.8%) at 20 sites in Korea were prospectively enrolled. The primary end point was late luminal loss (LLL) at 9-month follow-up angiography. Secondary end points included restenosis rates, target lesion failure (TLF), and DCB-related thrombosis during the 12-month follow-up period. We included 403 patients for analysis excluding 21 patients who required bailout stenting. Baseline mean reference vessel .diameter was 2.52 ± 0.39 mm and mean minimal luminal diameter (MLD) was 0.71 ± 0.40 mm. The mean MLD was 1.54 ± 0.37 mm after DCB. Late luminal loss was −0.01 ± 0.43 mm and restenosis was noted in 26 patients (12.2%). Minimal luminal diameter >1.6 mm and %diameter stenosis (DS)
      Citation: Angiology
      PubDate: 2021-05-13T09:17:16Z
      DOI: 10.1177/00033197211015534
       
  • Beyond Left Ventricular Ejection Fraction Improvement in the Optimization
           of Cardiac Resynchronization Therapy

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      Authors: Jose B. Cruz Rodriguez
      Abstract: Angiology, Ahead of Print.

      Citation: Angiology
      PubDate: 2021-05-12T09:47:50Z
      DOI: 10.1177/00033197211015551
       
  • Percutaneous Intervention in Diffuse Coronary Disease: Overlapping Versus
           Single Very Long Stent Technique. Results From the OVERLONG Registry

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      Authors: Martín Negreira-Caamaño, José Abellán-Huerta, Fernando Lozano-Ruiz-Poveda, Ignacio Sánchez-Pérez, María T. López-Lluva, Pedro Pérez-Díaz, Javier González López, Alfonso Jurado-Román
      Abstract: Angiology, Ahead of Print.
      Background:Both stent length and stent overlap are associated with worse outcomes in the percutaneous treatment of diffuse coronary artery disease (dCAD). However, evidence comparing these issues is scarce. We aimed to compare the results between the use of single very long stent (VLS) and ≥2 overlapping stents (OS) in the treatment of dCAD.Methods:Seven hundred twenty-four consecutive lesions were included: 275 treated with a single VLS (≥40 mm) and 449 with ≥2 OS. Procedural characteristics were assessed, and survival analysis was performed to compare the incidence of major adverse cardiovascular events (MACE; composite of cardiovascular death, nonfatal myocardial infarction, target lesion revascularization [TLR], or stent thrombosis) during a median follow-up of 31 months.Results:Procedures with VLS required less contrast volume (268 ± 122 vs 302 ± 113 cm3; P < .01), fluoroscopy time (16 ± 8 vs 21 ± 16 minutes; P < .01), and procedure duration (37 ± 18 vs 47 ± 27 minutes; P < .01) than the OS procedures. The VLS group showed lower incidence of MACE (4.4% vs 10.7%; P < .01), driven mainly by lower TLR rate (1.1% vs 4.7%; P < .01). The use of OS was an independent predictor of MACE.Conclusions:In this study, the use of VLS for the treatment of dCAD was associated with better outcomes compared to OS.
      Citation: Angiology
      PubDate: 2021-05-10T08:48:26Z
      DOI: 10.1177/00033197211014686
       
  • Relationship Between Fasting Glucose, HbA1c Levels, and the SYNTAX Score 2
           in Patients With Non-ST-Elevation Myocardial Infarction

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      Authors: Alparslan Kilic, Onur Baydar
      Abstract: Angiology, Ahead of Print.
      We evaluated if admission glycosylated hemoglobin (HbA1c) and fasting glucose levels are correlated with the severity of coronary artery disease (CAD) in non-ST-elevation myocardial infarction (NSTEMI), nondiabetic, patients. Coronary artery disease severity, according to the anatomical synergy between percutaneous coronary intervention (PCI) with taxus and cardiac surgery (SYNTAX) score 2 (SSII), was retrospectively evaluated in 359 nondiabetic patients hospitalized with NSTEMI who underwent coronary angiography. Glucose intolerance was assessed by serum fasting glucose and HbA1c levels. We stratified patients according to tertiles of SSII (≤21.5, 21.5-30.6, and ≥30.6). These score ranges were defined as SSII low, SSII mid, and SSII high, respectively. The average age of the patients was 57.1 ± 10.9 years; 189 (52.1%) patients were males. The average fasting glucose was 114 ± 52 mg/dL, HbA1c was 5.8% ± 0.9%, and SSII was 18.9 ± 10.3. A stronger correlation was found between HbA1c and SSII than fasting glucose and SSII (r1 = 0.901, P < .001, r2 = 0.378, P < .001, respectively), and HbA1c level and hypertension were independent risk factors for SSII high (odds ratio [OR]: 2.2 (95% CI: 0.5-9.0, P < .001; OR: 1.1 (1.0-1.3), P = .007, respectively). In conclusion, in nondiabetic patients with NSTEMI, HbA1c levels correlated with CAD severity as measured by the SSII.
      Citation: Angiology
      PubDate: 2021-05-07T09:16:47Z
      DOI: 10.1177/00033197211014678
       
  • Two-Year Clinical Outcomes According to Pre-PCI TIMI Flow Grade and
           Reperfusion Timing in Non-STEMI After Newer-Generation Drug-Eluting Stents
           Implantation

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      Authors: Yong Hoon Kim, Ae-Young Her, Myung Ho Jeong, Byeong-Keuk Kim, Sung-Jin Hong, Seunghwan Kim, Chul-Min Ahn, Jung-Sun Kim, Young-Guk Ko, Donghoon Choi, Myeong-Ki Hong, Yangsoo Jang
      Abstract: Angiology, Ahead of Print.
      The 2-year clinical outcomes according to pre-percutaneous coronary intervention (PCI) thrombolysis in myocardial infarction (TIMI) flow grade and reperfusion timing were investigated in patients with non-ST-segment elevation myocardial infarction (NSTEMI) who received newer-generation drug-eluting stents. A total of 7506 NSTEMI patients were divided into 2 groups: early (PCI ≤ 24 hours: n = 6398; pre-PCI TIMI 0/1 [n = 2729], pre-PCI TIMI 2/3 [n = 3669]) and delayed (PCI > 24 hours: n = 1108; pre-PCI TIMI 0/1 [n = 428], pre-PCI TIMI 2/3 [n = 680]) invasive groups. Major adverse cardiac events were defined as all-cause death, recurrent myocardial infarction, or any repeat revascularization. All-cause death (P = 0.005 and 0.009, respectively) and cardiac death (P = .003 and 0.046, respectively) were significantly higher in pre-PCI TIMI 0/1 patients than in pre-PCI TIMI 2/3 patients both in the early and delayed invasive groups. In pre-PCI TIMI 0/1 patients, all-cause death rate was significantly higher in the delayed group (P = .023). In pre-PCI TIMI 2/3 patients, the clinical end point was similar between the 2 groups. An early invasive strategy is preferred to a delayed invasive strategy in reducing all-cause death in patients with pre-PCI TIMI 0/1. However, in patients with pre-PCI TIMI 2/3, both treatment strategies are acceptable.
      Citation: Angiology
      PubDate: 2021-05-07T09:02:56Z
      DOI: 10.1177/00033197211012537
       
  • Intracoronary Imaging Versus Coronary Angiography to Guide Drug-Coated
           Balloon Intervention in Coronary Artery Disease: A Propensity-Matched
           Pilot Study Analysis

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      Authors: Sai Lv, Xiaoteng Ma, Yujie Zhou, Yingxin Zhao, Xiaoli Liu, Yuyang Liu, Dongmei Shi
      Abstract: Angiology, Ahead of Print.
      Limited data exist about the effect of intracoronary imaging (ICI)-guided drug-coated balloon (DCB) intervention on clinical end points. In all, 1157 patients with coronary artery disease treated with DCB between December 2014 and December 2017 at Beijing Anzhen Hospital were included in the final analysis in this cohort study. The primary end point was the incidence of target lesion failure (TLF), a composite of cardiac death, target vessel myocardial infarction (MI), and target lesion revascularization, and the key secondary end point was the incidence of cardiac death or target vessel MI. The median follow-up for clinical events was 32.0 months (IQR 25.0-40.0). Intracoronary imaging was used in 90 (7.8%) patients. There was no statistically significant difference in TLF (12.2% vs 12.5%, P = .80) between ICI-guided and angiography-guided group. Cardiac death or target vessel MI rates (1.1% vs 3.7%, P = .17) were numerically lower for the ICI-guided cohort. In the propensity score–based analysis, TLF (10.5% vs 16.2%, P = .19) and cardiac death or target vessel MI rates (1.2% vs 2.3%, P = .51) tended to be lower for the ICI-guided cohort. In this observational study, TLF rate tended to decrease in the ICI-guided DCB treatment group compared with angiography-guided procedures. Larger studies are needed.
      Citation: Angiology
      PubDate: 2021-05-07T09:02:04Z
      DOI: 10.1177/00033197211012518
       
  • Impact of Lymphocyte-Related Blood Parameters on Short- and Long-Term
           Outcomes of Patients Undergoing Thoracic Endovascular Aortic Repair

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      Authors: Fan Yang, Jitao Liu, Lyufan Chen, Ruixin Fan, Hongke Zeng, Qingshan Geng, Jianfang Luo
      Abstract: Angiology, Ahead of Print.
      Lymphocyte-related blood parameters (LRBP), including neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio, and lymphocyte-monocyte ratio, could reflect a patient’s overall inflammatory status. We aimed to clarify the association between preoperative LRBP and outcomes of type B aortic dissection (TBAD) patients undergoing thoracic endovascular aortic repair (TEVAR). A total of 841 patients were enrolled from 2010 to 2017. Twenty-six (3.1%) patients died during hospitalization and 71 (8.7%) patients died after a median follow-up of 47.3 months. Multivariate analyses showed that the NLR was the only independent predictor for in-hospital death (odds ratio, 1.15; 95% confidence interval [CI], 1.09-1.22; P < .001); 4.1 was identified as the optimum threshold for NLR after applying the X-tile program. Propensity score matching (PSM) was performed to diminish bias and yielded 174 matched pairs. Neutrophil-lymphocyte ratio >4.1 was demonstrated to be independently associated with follow-up mortality before (hazard ratio [HR], 2.53; 95% CI, 1.44-4.43; P = .001) and after PSM (HR, 3.11; 95% CI, 1.35-7.15; P = .008). The relationship between LRBP and follow-up reintervention or stroke were not significant (P > .05 for both). Elevated NLR was an independent indicator for in-hospital and follow-up mortality in patients with TBAD undergoing TEVAR; this might provide additional risk stratification.
      Citation: Angiology
      PubDate: 2021-05-06T09:24:44Z
      DOI: 10.1177/00033197211012514
       
  • The Atherogenic Index of Plasma: A Powerful and Reliable Predictor for
           Coronary Artery Disease in Patients With Type 2 Diabetes

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      Authors: Kuo Zhou, Zheng Qin, Jinfan Tian, Kongyong Cui, Yunfeng Yan, Shuzheng Lyu
      Abstract: Angiology, Ahead of Print.
      We evaluated the predictive power of the atherogenic index of plasma (AIP) for coronary artery disease (CAD) in patients with type 2 diabetes mellitus (T2DM). A total of 3278 patients who underwent coronary angiography were consecutively enrolled, including 2052 patients with CAD and 1226 patients with T2DM but without CAD. Patients in the CAD group had higher levels of triglyceride (TG), total cholesterol, low-density lipoprotein cholesterol, AIP and a lower level of high-density lipoprotein cholesterol (HDL-C). In correlation analyses, AIP correlated positively with body mass index, log (homeostasis model assessment of insulin resistance), TG, remnant lipoprotein cholesterol, non–HDL-C, but negatively with age and HDL-C. Multivariate logistic regression analyses demonstrated that AIP was an independent risk factor for CAD in diabetic patients and was validated by multiple models. Furthermore, the ORs for CAD risk were raised with increasing AIP quartiles; ORs of AIP quartiles Q2–Q4 compared with Q1 were 1.56, 1.70, and 2.22, respectively (Ps < .001), which suggested AIP was the lipid parameter that most strongly associated with incident CAD. In conclusion, AIP is a powerful and reliable biomarker for predicting CAD risk beyond individual lipid profiles in patients with T2DM.
      Citation: Angiology
      PubDate: 2021-05-05T09:39:39Z
      DOI: 10.1177/00033197211012129
       
  • Comparative Trial of the Effects of Left Ventricular and Biventricular
           Pacing on Indices of Cardiac Function and Clinical Course of Patients With
           Heart Failure: Rationale and Design of the READAPT Randomized Trial

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      Authors: Polychronis Dilaveris, Christos-Konstantinos Antoniou, Christina Chrysohoou, Panagiotis Xydis, Konstantinos Konstantinou, Panagiota Manolakou, Athanasios Kordalis, Konstantinos Gatzoulis, Costas Tsioufis
      Abstract: Angiology, Ahead of Print.
      Nonresponse to cardiac resynchronization therapy (CRT) has been related with right ventricular dysfunction. Ventriculoarterial coupling (VAC) assesses energy efficiency of the failing heart and stroke work maximization for a given contractility, for both systemic and pulmonary circulations. Preferential left ventricular pacing (pLVP) can overcome iatrogenic right ventricular dysfunction by achieving left ventricle resynchronization and by allowing for intrinsic activation of the right side, with ramifications extending beyond cardiac output and atrial fibrillation occurrence. In the present article, we detail the design of a single-center randomized clinical trial to evaluate the effects of a pLVP algorithm. More specifically, following randomization of 220 CRT-eligible patients to standard biventricular pacing and pLVP, their clinical course will be followed for 12 months, through echocardiography to study indices of systolic and diastolic function of ventricles, left and right side VAC to evaluate efficiency, and cardiopulmonary exercise test to objectively document improvements in functional status, as well as a self-reported quality of life questionnaire. Device programming will be based on echocardiography-evaluated maximization of stroke volume and subsequent interventricular and atrioventricular delay adjustments delegated to the device. Findings of this trial may provide evidence for alternative programming of the devices, linking pLVP to improved clinical outcomes.
      Citation: Angiology
      PubDate: 2021-05-03T09:22:13Z
      DOI: 10.1177/00033197211012520
       
  • Inflammatory Gene Expression in Neck Perivascular and Subcutaneous Adipose
           Tissue in Men With Carotid Stenosis

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      Authors: Vlatka Pandzic Jaksic, Danijela Grizelj, Ana Livun, Marko Ajduk, Drago Boscic, Ana Vlasic, Maruska Marusic, Branimir Gizdic, Rajko Kusec, Ozren Jaksic
      Abstract: Angiology, Ahead of Print.
      The inflammatory phenotype of neck adipose tissue (NAT) might reflect its involvement in the pathogenesis of carotid atherosclerosis. We investigated inflammatory gene expression in the subcutaneous and the perivascular (pericarotid) adipose tissue from patients with carotid stenosis (CS) undergoing endarterectomy and a control group of patients without significant carotid atherosclerosis undergoing thyroid surgery. Only male patients were included (n = 13 in each study group). Clinical and biochemical data along with serum leptin, adiponectin, and monocyte chemoattractant protein 1 (MCP-1) were collected. Adipose tissue samples were obtained from both the subcutaneous and pericarotid compartments. Real-time polymerase chain reaction was used to measure gene expression of macrophage markers and adipokines. The CS group had higher subcutaneous and pericarotid visfatin gene expression and higher pericarotid expression of MCP-1 and CD68 genes. The ratio between pericarotid CD206 and CD68 gene expression was similar between study groups. Adiponectin gene expression in both NAT compartments did not differ between groups, but it was negatively associated with body weight. These observations suggest that NAT, and especially the pericarotid compartment, express enhanced inflammatory properties in patients with CS, but the proportion of anti-inflammatory macrophages in advanced atherosclerosis seems to be maintained.
      Citation: Angiology
      PubDate: 2021-04-28T07:39:25Z
      DOI: 10.1177/00033197211012539
       
  • A Multifactorial Approach in Type 2 Diabetes Over 3 Years Decelerates
           Progression of Subclinical Arterial Disease in Routine Clinical Practice

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      Authors: George Konstantonis, Aikaterini Arida, Evaggelia Aissopou, Athanasios Protogerou, Nikolaοs Tentolouris, Petros P. Sfikakis, Konstantinos Makrilakis
      Abstract: Angiology, Ahead of Print.
      The beneficial effect of multifactorial treatment of cardiovascular (CV) risk factors (RFs) in type 2 diabetes (T2D) is well established from randomized clinical trials. We prospectively evaluated the impact of such treatment in a real-world setting, on the development of subclinical arterial damage (SAD), as determined by structural/functional noninvasive biomarkers of vascular pathology (atheromatosis, carotid hypertrophy, arteriosclerosis). We prospectively studied 116 persons with T2D, treated with a multifactorial approach for CV RFs at a tertiary medical center, and 324 individuals without diabetes, for 3.2 years. The primary outcome was changes in vascular biomarkers related to SAD. At baseline, participants in the diabetes group had higher prevalence of SAD. At study end, the changes in clinical, biochemical, and lifestyle characteristics, as well as antihypertensive and lipid-lowering treatments, were comparable between the 2 groups. During follow-up, classical CV RFs (smoking, blood pressure, low-density lipoprotein-cholesterol, triglycerides) and behavioral features were significantly improved in both groups. Multivariate analysis, after adjusting for all classic CV RFs and use of antihypertensive/lipid-lowering therapies, demonstrated that all evaluated SAD biomarkers were similarly changed in the 2 groups. In conclusion, implementation of a multimodality approach of T2D treatment is feasible and efficacious in decelerating progression of SAD in routine clinical practice.
      Citation: Angiology
      PubDate: 2021-04-28T07:30:24Z
      DOI: 10.1177/00033197211010622
       
  • The Role of Uric Acid in the Acute Myocardial Infarction: A Narrative
           Review

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      Authors: Atalay Demiray, Baris Afsar, Adrian Covic, Masanari Kuwabara, Charles J. Ferro, Miguel A. Lanaspa, Richard J. Johnson, Mehmet Kanbay
      Abstract: Angiology, Ahead of Print.
      Increased serum uric acid (SUA) levels have been associated with various pathologic processes such as increased oxidative stress, inflammation, and endothelial dysfunction. Thus, it is not surprising that increased SUA is associated with various adverse outcomes including cardiovascular (CV) diseases. Recent epidemiological evidence suggests that increased SUA may be related to acute myocardial infarction (AMI). Accumulating data also showed that elevated UA has pathophysiological role in the development of AMI. However, there are also studies showing that SUA is not related to the risk of AMI. In this narrative review, we summarized the recent literature data regarding SUA and AMI after providing some background information for the association between UA and coronary artery disease. Future studies will show whether decreasing SUA levels is beneficial for outcomes related to AMI and the optimum SUA levels for best outcomes in CV diseases.
      Citation: Angiology
      PubDate: 2021-04-27T07:47:50Z
      DOI: 10.1177/00033197211012546
       
  • Can C-Reactive Protein to Albumin Ratio Predict In-Hospital Death Rate Due
           to COVID-19 in Patients With Hypertension'

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      Authors: Faysal Saylik, Tayyar Akbulut, Safak Kaya
      Abstract: Angiology, Ahead of Print.
      Hypertension is one of the main morbidity and mortality risk factors in patients with coronavirus disease 2019 (COVID-19). We investigated the association between the C-reactive protein (CRP) to albumin ratio (CAR) and in-hospital mortality in patients with hypertensive COVID-19. A total of 176 patients with hypertension diagnosed with COVID-19 were included in this study. The CAR was compared between survivors and nonsurvivors. Logistic regression analysis was used to detect independent predictors of mortality due to COVID-19 in patients with hypertension. A cutoff value of CAR was obtained for predicting in-hospital death in patients with hypertensive COVID-19. Kaplan-Meier analysis was performed for survival analysis in the study population. The CAR values were significantly higher in nonsurvivors than in survivors with hypertension. Moreover, the CAR was an independent predictor of in-hospital death in patients with hypertensive COVID-19, as shown in multivariable logistic regression analysis. Receiver operating characteristic analysis yielded a cutoff value of 20.75 for the CAR for predicting in-hospital death in patients with hypertension. Kaplan-Meier curve analysis showed that patients with hypertensive COVID-19 with a CAR value of ≥20.75 had a higher incidence of in-hospital death. The CAR might be used as an independent predictor of in-hospital mortality in patients with hypertensive COVID-19.
      Citation: Angiology
      PubDate: 2021-04-27T07:38:10Z
      DOI: 10.1177/00033197211012145
       
  • Decreased Flow-Mediated Dilatation in Children With Type 1 Diabetes: A
           Systematic Review and Meta-Analysis

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      Authors: Lei Cao, Miao Hou, Wanping Zhou, Ling Sun, Jie Shen, Ye Chen, Yunjia Tang, Bo Wang, Xuan Li, Haitao Lv
      Abstract: Angiology, Ahead of Print.
      Type 1 diabetes (T1DM) is a strong risk factor for the development of cardiovascular disease. Flow-mediated dilatation (FMD) is an early noninvasive marker of endothelial function and it predicts future cardiovascular disease. However, the changes in FMD among T1DM children are still controversial. The present meta-analysis aimed to investigate whether FMD is impaired in children with T1DM. PubMed, EMBASE, Cochrane library, and Web of Science were searched for studies comparing FMD in children with T1DM and healthy controls. The Newcastle-Ottawa quality assessment scale for case–control studies was used to assess study quality. Data were pooled using a random effects models to obtain the weighted mean differences (WMD) in FMD and 95% CIs. Overall, 19 studies with 1245 patients and 872 healthy controls were included in this meta-analysis. Children with T1DM had significantly lower FMDs compared with healthy controls (WMD: −2.58; 95% CI: −3.36 to −1.81; P < .001). Meta-regression analysis revealed that low-density lipoprotein cholesterol levels impacted the observed difference in FMD between T1DM and healthy children. This meta-analysis showed that T1DM children have impaired endothelial function, which indicates they are at higher risk of developing cardiovascular disease in later life.
      Citation: Angiology
      PubDate: 2021-04-26T08:08:10Z
      DOI: 10.1177/00033197211010096
       
  • The Triglyceride-Glucose Index, a Predictor of Insulin Resistance, Is
           Associated With Subclinical Atherosclerosis

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      Authors: Onur Baydar, Alparslan Kilic, John Okcuoglu, Ziya Apaydin, Mehmet Mustafa Can
      Abstract: Angiology, Ahead of Print.
      Insulin resistance is one of the most important risk factors that accelerate atherosclerosis. The goal of this study is to investigate the relationship between the triglyceride glucose (TyG) index and functional vessel disease measured using pulse wave velocity (PWV), in a nondiabetic asymptomatic Turkish population. Nondiabetic, healthy patients (n = 1095) with no previous history of coronary heart disease were enrolled. Functional vessel disease was detected by measuring PWV. The TyG index was calculated using the following equation: log [fasting triglycerides (mg/dL) × fasting glucose (mg/dL)/2]. The study population was divided into 2 groups based on their TyG index. The high TyG index group had higher PWV, corrected PWV, left ventricular mass index, body mass index, rates of hypertension, and was predominately male. Age, gender, blood urea nitrogen level, and TyG index were detected as independent risk factors of PWV in linear regression analysis. Triglyceride glucose index and age were also independent risk factors of the corrected PWV in logistic regression analysis. These findings show a relationship between TyG index and subclinical vessel disease, even in patients without a history of atherosclerotic cardiovascular disease or diabetes.
      Citation: Angiology
      PubDate: 2021-04-23T07:09:01Z
      DOI: 10.1177/00033197211007719
       
  • The Association of a PRECISE-DAPT Score With No-Reflow in Patients With
           ST-Segment Elevation Myocardial Infarction

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      Authors: Murat Selçuk, Tufan Çınar, Faysal Şaylık, Önder Demiroz, Ersin Yıldırım
      Abstract: Angiology, Ahead of Print.
      This study aimed to evaluate the association of admission PREdicting bleeding Complications In patients undergoing Stent implantation and subsEquent Dual Anti Platelet Therapy (PRECISE-DAPT) score with the development of no-reflow (NR) in patients with ST-elevation myocardial infarction (STEMI) treated with primary percutaneous coronary intervention (PCI). In this observational, retrospective study, 335 consecutive STEMI patients who were treated with primary PCI were included. We classified the study population into 2 groups: patients with a PRECISE-DAPT score
      Citation: Angiology
      PubDate: 2021-04-21T07:08:40Z
      DOI: 10.1177/00033197211010602
       
  • Hazard-Ratio Likelihood for In-Hospital Death

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      Authors: Fatih Yılmaz
      Abstract: Angiology, Ahead of Print.

      Citation: Angiology
      PubDate: 2021-04-20T07:16:38Z
      DOI: 10.1177/0003319721990265
       
  • The Impact of Ranolazine Treatment on Liver Tests in Patients With
           Coronary Artery Disease and Nonalcoholic Fatty Liver Disease

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      Authors: Konstantinos P. Imprialos, Konstantinos Stavropoulos, Michael Doumas, Vasilios G. Athyros
      Abstract: Angiology, Ahead of Print.

      Citation: Angiology
      PubDate: 2021-04-08T07:58:28Z
      DOI: 10.1177/00033197211005597
       
  • Myocardial Injury and the Risk of Stroke in Patients With Chronic Kidney
           Disease (From the Chronic Renal Insufficiency Cohort Study)

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      Authors: Jamal Hajjari, Scott E. Janus, Zainab Albar, Sadeer G. Al-Kindi
      Abstract: Angiology, Ahead of Print.
      Patients with chronic kidney disease (CKD) are at increased risk for stroke. High-sensitivity troponin (hsTP), a marker of myocardial injury, has been associated with stroke risk in patients without CKD, but whether this applies to patients with CKD is not known. We assessed whether hsTP levels is associated with incident stroke in patients with mild-to-moderate CKD without a history of stroke enrolled in the Chronic Renal Insufficiency Cohort. Patients were followed for incident stroke, and the association with hsTP was assessed. A total of 3477 patients without prior stroke were included in this investigation. Over a median follow-up of 7.3 years, 101 (2.8%) patients had an incident stroke. Baseline hsTP was associated with a 9-year risk of stroke (quartile 1: 1.8%, quartile 2: 3.8%, quartile 3: 4.9%, quartile 4: 7.3%; P < .001). After adjusting for traditional stroke risk factors, patients in the fourth quartile (hazard ratio: 2.52, 95% CI: 1.10-5.76, P = .021) had higher risk of stroke when compared with the lowest quartile of hsTP. In conclusion, hsTP levels are associated with increased risk of incident stroke in patients with mild to moderate CKD, and this association remains significant despite the adjustment for traditional risk factors and CKD.
      Citation: Angiology
      PubDate: 2021-04-07T08:22:19Z
      DOI: 10.1177/00033197211005595
       
  • Evaluation of the Impact of Ranolazine Treatment on Liver Function Tests
           in Patients With Coronary Heart Disease and Nonalcoholic Fatty Liver
           Disease

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      Authors: Kerim Esenboğa, Alparslan Kurtul, Hüseyin Nazman, Cemre Gül Tekin, Nil Özyüncü, Türkan Seda Tan, Eralp Tutar, Sibel Tekin Turhan
      Abstract: Angiology, Ahead of Print.
      Nonalcoholic fatty liver disease (NAFLD) is the most common liver pathology in the developed world. Nonalcoholic fatty liver disease is associated with a higher risk of cardiovascular disease. We investigated the impact of ranolazine on liver tests in patients with NAFLD and coronary artery disease (CAD). Patients who had established CAD and NAFLD (as assessed by raised serum transaminase activity, sonographic criteria, and the absence of any other obvious liver disease) were allocated to “on ranolazine” (n = 40) or “not on ranolazine” (n = 35) groups. Serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were measured in all patients at baseline and at the end of the study. After 6 months of ranolazine treatment, both ALT and AST activities were significantly lower in patients in the “on ranolazine” group compared with “not on ranolazine” patients (change from baseline: ALT, −11.0 ± 1.7 IU/L, P < .001; AST, −5.2 ± 1.9 IU/L, P =.009). In conclusion, the present study showed that treatment with ranolazine for 6 months led to a significant reduction in the activities of both serum aminotransferases in patients with stable CAD and NAFLD.
      Citation: Angiology
      PubDate: 2021-04-07T08:21:20Z
      DOI: 10.1177/00033197211005590
       
  • AST/ALT Ratio and Peripheral Artery Disease in a Chinese Hypertensive
           Population: A Cross-Sectional Study

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      Authors: Hui Liu, Xiaoyuan Zha, Congcong Ding, Lihua Hu, Minghui Li, Yu Yu, Wei Zhou, Tao Wang, Lingjuan Zhu, Huihui Bao, Xiaoshu Cheng
      Abstract: Angiology, Ahead of Print.
      Previous studies reported that the aspartate aminotransferase (AST) to alanine aminotransferase (ALT) ratio (AST/ALT) was a risk factor in cardiovascular disease. Peripheral artery disease (PAD) is an important risk factor for cardiovascular death. However, only a few studies investigated the correlations between the AST/ALT ratio and PAD. We analyzed data from 10 900 patients with hypertension from the Chinese Hypertension Registry Study; 350 patients had PAD (prevalence 3.2%). After adjusting for potential confounders, the AST/ALT ratio was independently and positively associated with risk of PAD (OR: 1.31, 95% CI, 1.13-1.59), and a significant increased risk of PAD for the third AST/ALT ratio tertile (T3) compared with the first tertile (T1; OR: 1.49, 95% CI, 1.09-2.04, P trend = .005) was found. Moreover, when we combined T1 and T2 into one group and used it as a reference group, the risk of PAD increased with the increase in AST/ALT; the risk ratio was 1.52 (95% CI, 1.20-1.95). A higher AST/ALT ratio (≥1.65) was associated with PAD risk in Chinese adults with hypertension. Our results suggest that the AST/ALT ratio may help identify patients at high risk of vascular end points and might be a convenient, economical, and effective tool for evaluating the risk of atherosclerosis.
      Citation: Angiology
      PubDate: 2021-03-29T09:21:02Z
      DOI: 10.1177/00033197211004410
       
  • AST to ALT Ratio and Peripheral Arterial Disease in a Hypertensive
           Population—Is There a Link'

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      Authors: Emir Muzurović, Aart J. van der Lely, Mark Gurnell
      Abstract: Angiology, Ahead of Print.

      Citation: Angiology
      PubDate: 2021-03-24T09:30:12Z
      DOI: 10.1177/00033197211004387
       
  • Slow and Steady May Not Win This Race!

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      Authors: Manu Rajachandran, Ranjan Dahal
      Abstract: Angiology, Ahead of Print.

      Citation: Angiology
      PubDate: 2021-03-09T09:47:12Z
      DOI: 10.1177/0003319721999166
       
 
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