Publisher: Pharmaceutical Society of Japan (Total: 3 journals)   [Sort alphabetically]

Showing 1 - 3 of 3 Journals sorted by number of followers
Biological & Pharmaceutical Bulletin     Full-text available via subscription   (Followers: 3, SJR: 0.626, CiteScore: 2)
Chemical and Pharmaceutical Bulletin     Full-text available via subscription   (Followers: 1, SJR: 0.364, CiteScore: 1)
Yakugaku Zasshi     Open Access   (Followers: 1, SJR: 0.154, CiteScore: 0)
Similar Journals
Journal Cover
Chemical and Pharmaceutical Bulletin
Journal Prestige (SJR): 0.364
Citation Impact (citeScore): 1
Number of Followers: 1  
 
  Full-text available via subscription Subscription journal
ISSN (Print) 0009-2363 - ISSN (Online) 1347-5223
Published by Pharmaceutical Society of Japan  [3 journals]
  • Design, Synthesis, and Biological Evaluation of mTOR-targeting PROTACs
           Based on MLN0128 and Pomalidomide

    • Free pre-print version: Loading...

      Authors: Qi Zhang, Peizheng Yan, Pan Zhao, Dongsheng Zhao, Heran Cao, Jing Lu, Beibei Mao
      Abstract: mTOR is an effective anti-tumor drug target. Several mTOR kinase inhibitors have entered clinical research, but there are still challenges of potential toxicity. As a new type of targeted drug, proteolysis targeting chimeras (PROTACs) have features of low dosage and low toxicity. However, this approach has been rarely reported to involve mTOR degradation. In this study, the mTOR kinase inhibitor MLN0128 was used as the ligand to the protein of interest and conjugated with pomalidomide by diverse...
      Citation: Chemical & pharmaceutical bulletin
      PubDate: 2022-11-27
      DOI: 10.1248/cpb.c22-00576
       
  • Advanced solid-state NMR analysis of two crystal forms of ranitidine
           hydrochloride: Detection of 1H-14N intra-/intermolecular correlations

    • Free pre-print version: Loading...

      Authors: Hidetomo Yokoo, Seiji Tanaka, Eiichi Yamamoto, Genichiro Tsuji, Yosuke Demizu, Nahoko Uchiyama
      Abstract: Understanding the characteristics of crystal polymorphism of active pharmaceutical ingredients and analyzing them with high sensitivity is important for quality of drug products, appropriate characterization strategies, and appropriate screening and selection processes. However, there are few methods to measure intra- and intermolecular correlations in crystals other than X-ray crystallography, for which it is sometimes difficult to obtain suitable single crystals. Recently, solid-state NMR has...
      Citation: Chemical & pharmaceutical bulletin
      PubDate: 2022-10-26
      DOI: 10.1248/cpb.c22-00628
       
  • Quantitative 31P-NMR for purity determination of sofosbuvir and
           method validation

    • Free pre-print version: Loading...

      Authors: Nahoko Uchiyama, Kohei Kiyota, Junko Hosoe, Takanori Komatsu, Naoki Sugimoto, Kyoko Ishizuki, Tatsuo Koide, Mika Murabayashi, Kengo Kobayashi, Yoshinori Fujimine, Toshiyuki Yokose, Katsuya Ofuji, Hitoshi Shimizu, Takashi Hasebe, Yumi Asai, Eri Ena, Junko Kikuchi, Kazuhiro Fujita, Yoshinobu Makino, Yoshiaki Iwamoto, Toru Miura, Yasuhiro Muto, Katsuo Asakura, Takako Suematsu, Hitomi Muto, Ai Kohama, Takashi Goto, Masu Yasuda, Tomohiko Ueda, Yukihiro Goda
      Abstract: Quantitative ¹H-NMR (¹H-qNMR) is useful for determining the absolute purity of organic molecules; however, it is sometimes difficult to identify the target signal(s) for quantitation because of their overlap and complexity. Therefore, we focused on the ^(31)P nucleus because of the simplicity of its signals and previously reported ^(31)P-qNMR in D(2)O. Here we report ^(31)P-qNMR of an organophosphorus compound, sofosbuvir (SOF), which is soluble in organic solvents. Phosphonoacetic acid (PAA)...
      Citation: Chemical & pharmaceutical bulletin
      PubDate: 2022-10-12
      DOI: 10.1248/cpb.c22-00639
       
  • Research Progress on the Mechanism of Reducing Toxicity and Increasing the
           Efficacy of Sini Decoction Compatibility

    • Free pre-print version: Loading...

      Authors: Chen Hao, Huang Yi, Liu Hong, Yang Ming, Tong Hengli, Gong Feipeng, Zhong Lingyun
      Abstract: Sini Decoction (SND) is the main prescription for treating Shaoyin disease in Zhang Zhongjing's Treatise on Typhoid Diseases in Han Dynasty. It is composed of Aconitum carmichaeli Debeaux, Glycyrrhiza uralensis Fisch ex DC and Zingiber officinale Roscoe. It has the effects of warming middle-jiao to dispel cold and revive the yang for resuscitation. Nowadays, it is mainly used in diseases in cardiovascular system, nervous system, digestive system and so on. In this paper, the effect and mechanism...
      Citation: Chemical & pharmaceutical bulletin
      PubDate: 2022-09-19
      DOI: 10.1248/cpb.c22-00380
       
 
JournalTOCs
School of Mathematical and Computer Sciences
Heriot-Watt University
Edinburgh, EH14 4AS, UK
Email: journaltocs@hw.ac.uk
Tel: +00 44 (0)131 4513762
 


Your IP address: 18.232.56.9
 
Home (Search)
API
About JournalTOCs
News (blog, publications)
JournalTOCs on Twitter   JournalTOCs on Facebook

JournalTOCs © 2009-