Publisher: American Society for Cell Biology (Total: 2 journals) [Sort by number of followers]
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Molecular Biology of the Cell
Journal Prestige (SJR): 2.935 ![]() Citation Impact (citeScore): 4 Number of Followers: 26 ![]() ISSN (Print) 1059-1524 - ISSN (Online) 1939-4586 Published by American Society for Cell Biology [2 journals] |
- Preprint Highlight: mRNA Location and Translation Rate Determine Protein
Targeting to Dual Destinations
Open Access Article
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Authors: Adriana R. Mantegazza
Abstract: Molecular Biology of the Cell, Volume 34, Issue 7, June 01, 2023.
NET1 is a guanine nucleotide exchange factor for RhoA GTPase that plays different roles in the nucleus and cytoplasm. While perinuclear and peripheral mRNA translation sites have been identified, the mechanisms of spatial translation regulation and impacts on protein function are not generally understood. Here, the authors use genetic tools to manipulate NET1 mRNA targeting sequences, as well as proximity ligation, mass spectrometry, and imaging. They show that mRNA localization, translation rate, and the order of appearance of targeting domains during translation determine the extent of protein synthesis in each location, promoting site-specific NET1 function. This novel regulation of protein targeting by RNA translation rate and location uncovers the potential to engineer mRNA localization to optimize protein function and will likely impact research on cell biology, immunology, and beyond. This preprint has been assigned the following badges: New Hypothesis, New Methods, Open Software, Cross-Validation. Read the preprint on bioRxiv (Gasparski et al., 2023): https://doi.org/10.1101/2023.04.24.538105.
Citation: Molecular Biology of the Cell
PubDate: 2023-05-30T05:09:12Z
DOI: 10.1091/mbc.P23-05-0015
Issue No: Vol. 34, No. 7 (2023)
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- Preprint Highlight: Contractile ring mechanosensation and its
anillin-dependent tuning during early embryogenesis
Open Access Article
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Authors: Jennifer Landino
Abstract: Molecular Biology of the Cell, Volume 34, Issue 7, June 01, 2023.
Dividing cells assemble and constrict a contractile ring made up of actin and myosin anchored to the cell cortex. How the contractile ring senses the mechanics of the cell cortex is not known. With asymmetric ring closure in C. elegans as a model, the authors used novel 4D imaging and image segmentation methods to carefully track ring closure over time. They found that ring-directed cortical flow underlies mechanosensation and supports a positive feedback loop between ring closure, cortical flow, and myosin accumulation. These findings suggest that differences in cell cortex stiffness may determine the orientation and type of cell division–i.e., asymmetric vs. symmetric ring closure. As tissue morphogenesis often relies on specifically oriented cell divisions, defining mechanisms of ring closure is essential for understanding multicellular development. This preprint has been assigned the following badges: New Methods, New Hypothesis. Read the preprint on bioRxiv (Hsu et al., 2023): https://doi.org/10.1101/2022.09.09.506560.
Citation: Molecular Biology of the Cell
PubDate: 2023-05-30T05:09:08Z
DOI: 10.1091/mbc.P23-05-0016
Issue No: Vol. 34, No. 7 (2023)
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- Challenges and opportunities in maintaining research momentum at a
primarily undergraduate institution-
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Authors: Mariana Torrente, Ozlem Dilek
Abstract: Molecular Biology of the Cell, Volume 34, Issue 7, June 01, 2023.
Citation: Molecular Biology of the Cell
PubDate: 2023-05-19T02:49:50Z
DOI: 10.1091/mbc.E23-01-0026
Issue No: Vol. 34, No. 7 (2023)
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- Role of 2-hydroxy acyl-CoA lyase HACL2 in odd-chain fatty acid production
via α-oxidation in vivo-
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Authors: Keisuke Mori, Tatsuro Naganuma, Akio Kihara
Abstract: Molecular Biology of the Cell, Ahead of Print.
Citation: Molecular Biology of the Cell
PubDate: 2023-06-07T04:25:26Z
DOI: 10.1091/mbc.E23-02-0042
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- Divergent regulation of α-arrestin ARRDC3 function by ubiquitination
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Authors: Helen Wedegaertner, Oye Bosompra, Irina Kufareva, JoAnn Trejo
Abstract: Molecular Biology of the Cell, Ahead of Print.
Citation: Molecular Biology of the Cell
PubDate: 2023-05-24T03:48:28Z
DOI: 10.1091/mbc.E23-02-0055
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- Enabled primarily controls filopodial morphology, not actin organization,
in the TSM1 growth cone in Drosophila-
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Authors: Hsiao Yu Fang, Rameen Forghani, Akanni Clarke, Philip G. McQueen, Aravind Chandrasekaran, Kate M. O'Neill, Wolfgang Losert, Garegin A. Papoian, Edward Giniger
Abstract: Molecular Biology of the Cell, Ahead of Print.
Citation: Molecular Biology of the Cell
PubDate: 2023-05-24T03:48:08Z
DOI: 10.1091/mbc.E23-01-0003
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- High extracellular glucose promotes cell motility by modulating cell
deformability and contractility via cAMP-RhoA-ROCK axis in human breast
cancer cells-
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Authors: Mijung Oh, Skylar Batty, Nayan Banerjee, Tae-Hyung Kim
Abstract: Molecular Biology of the Cell, Ahead of Print.
Citation: Molecular Biology of the Cell
PubDate: 2023-05-17T03:46:28Z
DOI: 10.1091/mbc.E22-12-0560
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- The short-chain fatty acid acetate coordinates with CD30 to modulate T
cell survival-
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Authors: Junfang Lyu, Ziyi Li, Jessica Roberts, Yue A. Qi, Jianhua Xiong
Abstract: Molecular Biology of the Cell, Ahead of Print.
Citation: Molecular Biology of the Cell
PubDate: 2023-05-10T03:47:55Z
DOI: 10.1091/mbc.E23-01-0032
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- Polychaetoid/ZO-1 strengthens cell junctions under tension while
localizing differently than core adherens junction proteins-
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Authors: Anja Schmidt, Tara Finegan, Matthias Häring, Deqing Kong, Alexander G Fletcher, Zuhayr Alam, Jörg Grosshans, Fred Wolf, Mark Peifer
Abstract: Molecular Biology of the Cell, Ahead of Print.
Citation: Molecular Biology of the Cell
PubDate: 2023-05-10T03:47:25Z
DOI: 10.1091/mbc.E23-03-0077
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- Polo-like kinase 4 homodimerization and condensate formation regulate its
own protein levels but are not required for centriole assembly-
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Authors: John M. Ryniawec, Daniel W. Buster, Lauren K. Slevin, Cody J. Boese, Anastasia Amoiroglou, Spencer M. Dean, Kevin C. Slep, Gregory C. Rogers
Abstract: Molecular Biology of the Cell, Ahead of Print.
Citation: Molecular Biology of the Cell
PubDate: 2023-05-10T03:47:22Z
DOI: 10.1091/mbc.E22-12-0572
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- The Tetrahymena bcd1 mutant implicates endosome trafficking in ciliate,
cortical pattern formation-
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Authors: Eric S. Cole, Wolfgang Maier, Ewa Joachimiak, Yu-yang Jiang, Chinkyu Lee, Erik Collet, Carl Chmelik, Daniel P. Romero, Douglas Chalker, Nurudeen K. Alli, Tina M. Ruedlin, Courtney Ozzello, Jacek Gaertig
Abstract: Molecular Biology of the Cell, Ahead of Print.
Citation: Molecular Biology of the Cell
PubDate: 2023-05-10T03:47:02Z
DOI: 10.1091/mbc.E22-11-0501
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- The calcium binding Cab45 regulates the polarized apical secretion of
soluble proteins in epithelial cells-
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Authors: Dandan Liu, Simona Paladino, Chiara Zurzolo, Stéphanie Lebreton
Abstract: Molecular Biology of the Cell, Ahead of Print.
Citation: Molecular Biology of the Cell
PubDate: 2023-05-10T03:46:55Z
DOI: 10.1091/mbc.E22-12-0549
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- Acetate regulates GAPDH acetylation and T helper 1 cell differentiation
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Authors: Xizhong Jing, Junfang Lyu, Jianhua Xiong
Abstract: Molecular Biology of the Cell, Ahead of Print.
Citation: Molecular Biology of the Cell
PubDate: 2023-05-03T04:02:37Z
DOI: 10.1091/mbc.E23-02-0070
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- Outer Arm Dynein Light Chain LC1 Is Required for Normal Motor Assembly
Kinetics, Ciliary Stability and Motility-
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Authors: Miho Sakato-Antoku, Stephen M. King
Abstract: Molecular Biology of the Cell, Ahead of Print.
Citation: Molecular Biology of the Cell
PubDate: 2023-05-03T04:02:18Z
DOI: 10.1091/mbc.E23-03-0104
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- Loops and the activity of loop extrusion factors constrain chromatin
dynamics-
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Authors: Mary Lou P. Bailey, Ivan Surovtsev, Jessica F. Williams, Hao Yan, Tianyu Yuan, Kevin Li, Katherine Duseau, Simon G. J. Mochrie, Megan C. King
Abstract: Molecular Biology of the Cell, Ahead of Print.
Citation: Molecular Biology of the Cell
PubDate: 2023-04-26T03:52:37Z
DOI: 10.1091/mbc.E23-04-0119
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- Microtubule competition and cell growth recenter the nucleus after
anaphase in fission yeast-
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Authors: Kimberly Bellingham-Johnstun, Annelise Thorn, Julio M. Belmonte, Caroline Laplante
Abstract: Molecular Biology of the Cell, Ahead of Print.
Citation: Molecular Biology of the Cell
PubDate: 2023-04-26T03:52:17Z
DOI: 10.1091/mbc.E23-01-0034
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- The role of kinetochore dynein in checkpoint silencing is restricted to
disassembly of the corona-
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Authors: Amy H. Ide, Keith F. DeLuca, O'Neil Wiggan, Steven M. Markus, Jennifer G. DeLuca
Abstract: Molecular Biology of the Cell, Ahead of Print.
Citation: Molecular Biology of the Cell
PubDate: 2023-04-26T03:51:37Z
DOI: 10.1091/mbc.E23-04-0130
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- Endothelial Tip-Stalk Cell Selection requires BMP9-induced βIV-spectrin
Expression During Sprouting Angiogenesis-
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Authors: Tasmia Ahmed, Aaron Ramonett, Eun-A Kwak, Sanjay Kumar, Paola Cruz Flores, Hannah R. Ortiz, Paul R. Langlais, Thomas J. Hund, Karthikeyan Mythreye, Nam Y. Lee
Abstract: Molecular Biology of the Cell, Ahead of Print.
Citation: Molecular Biology of the Cell
PubDate: 2023-04-26T03:51:17Z
DOI: 10.1091/mbc.E23-02-0064
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- Megalin, cubilin, and Dab2 drive endocytic flux in kidney proximal tubule
cells-
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Authors: Youssef Rbaibi, Kimberly R. Long, Katherine E. Shipman, Qidong Ren, Catherine J. Baty, Ossama B. Kashlan, Ora A. Weisz
Abstract: Molecular Biology of the Cell, Ahead of Print.
Citation: Molecular Biology of the Cell
PubDate: 2023-04-26T03:50:57Z
DOI: 10.1091/mbc.E22-11-0510
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- Multiple tethers of organelle contact sites are involved in
α-synuclein toxicity in yeast-
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Authors: Mara Del Vecchio, Lucia Amado, Alexandra P. Cogan, Els Meert, Joelle Rosseels, Vanessa Franssens, Sander K. Govers, Joris Winderickx, Ayelén González Montoro
Abstract: Molecular Biology of the Cell, Ahead of Print.
Citation: Molecular Biology of the Cell
PubDate: 2023-04-19T04:53:05Z
DOI: 10.1091/mbc.E23-01-0029
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- Glutamylation is a negative regulator of microtubule growth
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Authors: Jiayi Chen, Antonina Roll-Mecak
Abstract: Molecular Biology of the Cell, Ahead of Print.
Citation: Molecular Biology of the Cell
PubDate: 2023-04-19T04:52:27Z
DOI: 10.1091/mbc.E23-01-0030
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- Non-muscle myosin IIB is a driver of cellular reprogramming
-
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Authors: Amanda E. Balaban, Ly T.S. Nguyen, Eleana Parajón, Douglas N. Robinson
Abstract: Molecular Biology of the Cell, Ahead of Print.
Citation: Molecular Biology of the Cell
PubDate: 2023-04-19T04:52:06Z
DOI: 10.1091/mbc.E21-08-0386
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- Paxillin Regulates Rab5-mediated Vesicle Motility through Modulating
Microtubule Acetylation-
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Authors: Nicholas M. Zehrbach, Fatemeh Dubois, Christopher E. Turner
Abstract: Molecular Biology of the Cell, Ahead of Print.
Citation: Molecular Biology of the Cell
PubDate: 2023-04-12T04:09:08Z
DOI: 10.1091/mbc.E22-10-0455
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- Microenvironmental mechanoactivation through Yap/Taz suppresses
chondrogenic gene expression-
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Authors: Grey F. Hallström, Dakota L. Jones, Ryan C. Locke, Edward D. Bonnevie, Sung Yeon Kim, Lorielle Laforest, Diana Cruz Garcia, Robert L. Mauck
Abstract: Molecular Biology of the Cell, Ahead of Print.
Citation: Molecular Biology of the Cell
PubDate: 2023-04-12T04:08:08Z
DOI: 10.1091/mbc.E22-12-0543
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- The RhoGEF protein Plekhg5 regulates medioapical and junctional actomyosin
dynamics of apical constriction during Xenopus gastrulation-
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Authors: Austin Baldwin, Ivan K. Popov, Ray Keller, John Wallingford, Chenbei Chang
Abstract: Molecular Biology of the Cell, Ahead of Print.
Citation: Molecular Biology of the Cell
PubDate: 2023-04-12T04:07:48Z
DOI: 10.1091/mbc.E22-09-0411
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- Quantitative analysis of morphogenesis and growth dynamics in an obligate
intracellular bacterium-
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Authors: Wanda M. Figueroa-Cuilan, Oihane Irazoki, Marissa Feeley, Erika Smith, Trung Nguyen, Felipe Cava, Erin D. Goley
Abstract: Molecular Biology of the Cell, Ahead of Print.
Citation: Molecular Biology of the Cell
PubDate: 2023-04-05T01:39:45Z
DOI: 10.1091/mbc.E23-01-0023
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- Woronin body hitchhiking on early endosomes is dispensable for septal
localization in Aspergillus nidulans-
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Authors: Livia D. Songster, Devahuti Bhuyan, Jenna R. Christensen, Samara L. Reck-Peterson
Abstract: Molecular Biology of the Cell, Ahead of Print.
Citation: Molecular Biology of the Cell
PubDate: 2023-04-05T01:38:45Z
DOI: 10.1091/mbc.E23-01-0025
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- ULK4 and Fused/STK36 interact to mediate assembly of a motile flagellum
-
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Authors: Ciaran J. McCoy, Humbeline Paupelin-Vaucelle, Peter Gorilak, Tom Beneke, Vladimir Varga, Eva Gluenz
Abstract: Molecular Biology of the Cell, Ahead of Print.
Citation: Molecular Biology of the Cell
PubDate: 2023-03-29T03:52:15Z
DOI: 10.1091/mbc.E22-06-0222
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- Dendritic effects of genetically encoded actin labelling probes in
cultured hippocampal neurons-
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Authors: Attila Ignácz, Domonkos Nagy-Herczeg, Angelika Hausser, Katalin Schlett
Abstract: Molecular Biology of the Cell, Ahead of Print.
Citation: Molecular Biology of the Cell
PubDate: 2023-03-29T03:51:02Z
DOI: 10.1091/mbc.E22-08-0331
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- Regulation of neurofilament length and transport by a dynamic cycle of
phospho-dependent polymer severing and annealing-
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Authors: Atsuko Uchida, Juan Peng, Anthony Brown
Abstract: Molecular Biology of the Cell, Ahead of Print.
Citation: Molecular Biology of the Cell
PubDate: 2023-03-29T03:50:54Z
DOI: 10.1091/mbc.E23-01-0024
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- The Arp2/3 Complex Enhances Cell Migration on Elastic Substrates
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Authors: Devin B Mair, Ceylin Elmasli, June Hyung Kim, Amanda D. Barreto, Supeng Ding, Luo Gu, Seth H Weinberg, Taeyoon Kim, Deok-Ho Kim, Rong Li
Abstract: Molecular Biology of the Cell, Ahead of Print.
Citation: Molecular Biology of the Cell
PubDate: 2023-03-29T03:50:15Z
DOI: 10.1091/mbc.E22-06-0243
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