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Keio J. of Medicine     Partially Free   (SJR: 0.267, CiteScore: 1)
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Keio Journal of Medicine
Journal Prestige (SJR): 0.267
Citation Impact (citeScore): 1
Number of Followers: 0  
 
  Partially Free Journal Partially Free Journal
ISSN (Print) 0022-9717 - ISSN (Online) 1880-1293
Published by Keio University Homepage  [1 journal]
  • The Unlikely Development of CAR T Cells: a Brief History and Prospects for
           the Future

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: Keio J Med. 2023;72(1):26. doi: 10.2302/kjm.ABSTRACT_72_1-1.ABSTRACTThe quest to cure cancer has been one of the Holy Grails of medicine. The discovery I am going to share with you, CAR T cells, is a promising new form of therapy of cancer that offers the prospect of curing cancer using the immune system. CAR T cells are the first form of synthetic biology to enter the practice of medicine. The notion of using the immune system to fight cancer is an old idea. Over a century ago, bacteria were ground up and injected into patients with late-stage cancers, and occasionally the cancer would disappear. However, we now have precise tools for genetic editing and gene insertion like CRISPR/Cas9 to rewrite the DNA code, offering the possibility to improve the immune system over what has evolved in ...
      PubDate: Sat, 03 Jun 2023 21:25:03 +010
      DOI: 10.2302/kjm.abstract_72_1-1.abstractthe quest to cure cancer has been one of the holy grails of medi
       
  • Addressing the Threat of Emerging Viral Infections

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: Keio J Med. 2023;72(1):27. doi: 10.2302/kjm.ABSTRACT_72_1-2.ABSTRACTEmerging infections are caused when microorganisms that are maintained in a reservoir where they cause no harm, transmit from the reservoir to a new host. I have been studying the replication, molecular basis for pathogenesis, and host responses to emerging viruses, including influenza virus, Ebola virus, and SARS-CoV-2, and using the knowledge gained from these studies to develop antivirals and vaccines.Influenza viruses cause epidemics every winter, but occasionally new influenza viruses emerge and spread worldwide (pandemic). We established a technique that allows us to make influenza viruses artificially. This technique is now widely used for basic research and for the development of vaccines against highly pathogenic ...
      PubDate: Sat, 03 Jun 2023 21:25:03 +010
      DOI: 10.2302/kjm.abstract_72_1-2.abstractemerging infections are caused when microorganisms that are main
       
  • The Unlikely Development of CAR T Cells: a Brief History and Prospects for
           the Future

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: Keio J Med. 2023;72(1):26. doi: 10.2302/kjm.ABSTRACT_72_1-1.ABSTRACTThe quest to cure cancer has been one of the Holy Grails of medicine. The discovery I am going to share with you, CAR T cells, is a promising new form of therapy of cancer that offers the prospect of curing cancer using the immune system. CAR T cells are the first form of synthetic biology to enter the practice of medicine. The notion of using the immune system to fight cancer is an old idea. Over a century ago, bacteria were ground up and injected into patients with late-stage cancers, and occasionally the cancer would disappear. However, we now have precise tools for genetic editing and gene insertion like CRISPR/Cas9 to rewrite the DNA code, offering the possibility to improve the immune system over what has evolved in ...
      PubDate: Sat, 03 Jun 2023 21:25:03 +010
      DOI: 10.2302/kjm.abstract_72_1-1.abstractthe quest to cure cancer has been one of the holy grails of medi
       
  • Addressing the Threat of Emerging Viral Infections

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: Keio J Med. 2023;72(1):27. doi: 10.2302/kjm.ABSTRACT_72_1-2.ABSTRACTEmerging infections are caused when microorganisms that are maintained in a reservoir where they cause no harm, transmit from the reservoir to a new host. I have been studying the replication, molecular basis for pathogenesis, and host responses to emerging viruses, including influenza virus, Ebola virus, and SARS-CoV-2, and using the knowledge gained from these studies to develop antivirals and vaccines.Influenza viruses cause epidemics every winter, but occasionally new influenza viruses emerge and spread worldwide (pandemic). We established a technique that allows us to make influenza viruses artificially. This technique is now widely used for basic research and for the development of vaccines against highly pathogenic ...
      PubDate: Sat, 03 Jun 2023 21:25:03 +010
      DOI: 10.2302/kjm.abstract_72_1-2.abstractemerging infections are caused when microorganisms that are main
       
  • The Unlikely Development of CAR T Cells: a Brief History and Prospects for
           the Future

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: Keio J Med. 2023;72(1):26. doi: 10.2302/kjm.ABSTRACT_72_1-1.ABSTRACTThe quest to cure cancer has been one of the Holy Grails of medicine. The discovery I am going to share with you, CAR T cells, is a promising new form of therapy of cancer that offers the prospect of curing cancer using the immune system. CAR T cells are the first form of synthetic biology to enter the practice of medicine. The notion of using the immune system to fight cancer is an old idea. Over a century ago, bacteria were ground up and injected into patients with late-stage cancers, and occasionally the cancer would disappear. However, we now have precise tools for genetic editing and gene insertion like CRISPR/Cas9 to rewrite the DNA code, offering the possibility to improve the immune system over what has evolved in ...
      PubDate: Sat, 03 Jun 2023 21:25:03 +010
      DOI: 10.2302/kjm.abstract_72_1-1.abstractthe quest to cure cancer has been one of the holy grails of medi
       
  • Addressing the Threat of Emerging Viral Infections

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: Keio J Med. 2023;72(1):27. doi: 10.2302/kjm.ABSTRACT_72_1-2.ABSTRACTEmerging infections are caused when microorganisms that are maintained in a reservoir where they cause no harm, transmit from the reservoir to a new host. I have been studying the replication, molecular basis for pathogenesis, and host responses to emerging viruses, including influenza virus, Ebola virus, and SARS-CoV-2, and using the knowledge gained from these studies to develop antivirals and vaccines.Influenza viruses cause epidemics every winter, but occasionally new influenza viruses emerge and spread worldwide (pandemic). We established a technique that allows us to make influenza viruses artificially. This technique is now widely used for basic research and for the development of vaccines against highly pathogenic ...
      PubDate: Sat, 03 Jun 2023 21:25:03 +010
      DOI: 10.2302/kjm.abstract_72_1-2.abstractemerging infections are caused when microorganisms that are main
       
  • The Unlikely Development of CAR T Cells: a Brief History and Prospects for
           the Future

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: Keio J Med. 2023;72(1):26. doi: 10.2302/kjm.ABSTRACT_72_1-1.ABSTRACTThe quest to cure cancer has been one of the Holy Grails of medicine. The discovery I am going to share with you, CAR T cells, is a promising new form of therapy of cancer that offers the prospect of curing cancer using the immune system. CAR T cells are the first form of synthetic biology to enter the practice of medicine. The notion of using the immune system to fight cancer is an old idea. Over a century ago, bacteria were ground up and injected into patients with late-stage cancers, and occasionally the cancer would disappear. However, we now have precise tools for genetic editing and gene insertion like CRISPR/Cas9 to rewrite the DNA code, offering the possibility to improve the immune system over what has evolved in ...
      PubDate: Mon, 29 May 2023 01:46:04 +010
      DOI: 10.2302/kjm.abstract_72_1-1.abstractthe quest to cure cancer has been one of the holy grails of medi
       
  • Addressing the Threat of Emerging Viral Infections

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: Keio J Med. 2023;72(1):27. doi: 10.2302/kjm.ABSTRACT_72_1-2.ABSTRACTEmerging infections are caused when microorganisms that are maintained in a reservoir where they cause no harm, transmit from the reservoir to a new host. I have been studying the replication, molecular basis for pathogenesis, and host responses to emerging viruses, including influenza virus, Ebola virus, and SARS-CoV-2, and using the knowledge gained from these studies to develop antivirals and vaccines.Influenza viruses cause epidemics every winter, but occasionally new influenza viruses emerge and spread worldwide (pandemic). We established a technique that allows us to make influenza viruses artificially. This technique is now widely used for basic research and for the development of vaccines against highly pathogenic ...
      PubDate: Mon, 29 May 2023 01:46:04 +010
      DOI: 10.2302/kjm.abstract_72_1-2.abstractemerging infections are caused when microorganisms that are main
       
  • The Unlikely Development of CAR T Cells: a Brief History and Prospects for
           the Future

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: Keio J Med. 2023;72(1):26. doi: 10.2302/kjm.ABSTRACT_72_1-1.ABSTRACTThe quest to cure cancer has been one of the Holy Grails of medicine. The discovery I am going to share with you, CAR T cells, is a promising new form of therapy of cancer that offers the prospect of curing cancer using the immune system. CAR T cells are the first form of synthetic biology to enter the practice of medicine. The notion of using the immune system to fight cancer is an old idea. Over a century ago, bacteria were ground up and injected into patients with late-stage cancers, and occasionally the cancer would disappear. However, we now have precise tools for genetic editing and gene insertion like CRISPR/Cas9 to rewrite the DNA code, offering the possibility to improve the immune system over what has evolved in ...
      PubDate: Mon, 29 May 2023 01:46:04 +010
      DOI: 10.2302/kjm.abstract_72_1-1.abstractthe quest to cure cancer has been one of the holy grails of medi
       
  • Addressing the Threat of Emerging Viral Infections

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: Keio J Med. 2023;72(1):27. doi: 10.2302/kjm.ABSTRACT_72_1-2.ABSTRACTEmerging infections are caused when microorganisms that are maintained in a reservoir where they cause no harm, transmit from the reservoir to a new host. I have been studying the replication, molecular basis for pathogenesis, and host responses to emerging viruses, including influenza virus, Ebola virus, and SARS-CoV-2, and using the knowledge gained from these studies to develop antivirals and vaccines.Influenza viruses cause epidemics every winter, but occasionally new influenza viruses emerge and spread worldwide (pandemic). We established a technique that allows us to make influenza viruses artificially. This technique is now widely used for basic research and for the development of vaccines against highly pathogenic ...
      PubDate: Mon, 29 May 2023 01:46:04 +010
      DOI: 10.2302/kjm.abstract_72_1-2.abstractemerging infections are caused when microorganisms that are main
       
  • The Unlikely Development of CAR T Cells: a Brief History and Prospects for
           the Future

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: Keio J Med. 2023;72(1):26. doi: 10.2302/kjm.ABSTRACT_72_1-1.ABSTRACTThe quest to cure cancer has been one of the Holy Grails of medicine. The discovery I am going to share with you, CAR T cells, is a promising new form of therapy of cancer that offers the prospect of curing cancer using the immune system. CAR T cells are the first form of synthetic biology to enter the practice of medicine. The notion of using the immune system to fight cancer is an old idea. Over a century ago, bacteria were ground up and injected into patients with late-stage cancers, and occasionally the cancer would disappear. However, we now have precise tools for genetic editing and gene insertion like CRISPR/Cas9 to rewrite the DNA code, offering the possibility to improve the immune system over what has evolved in ...
      PubDate: Mon, 29 May 2023 01:46:04 +010
      DOI: 10.2302/kjm.abstract_72_1-1.abstractthe quest to cure cancer has been one of the holy grails of medi
       
  • Addressing the Threat of Emerging Viral Infections

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: Keio J Med. 2023;72(1):27. doi: 10.2302/kjm.ABSTRACT_72_1-2.ABSTRACTEmerging infections are caused when microorganisms that are maintained in a reservoir where they cause no harm, transmit from the reservoir to a new host. I have been studying the replication, molecular basis for pathogenesis, and host responses to emerging viruses, including influenza virus, Ebola virus, and SARS-CoV-2, and using the knowledge gained from these studies to develop antivirals and vaccines.Influenza viruses cause epidemics every winter, but occasionally new influenza viruses emerge and spread worldwide (pandemic). We established a technique that allows us to make influenza viruses artificially. This technique is now widely used for basic research and for the development of vaccines against highly pathogenic ...
      PubDate: Mon, 29 May 2023 01:46:04 +010
      DOI: 10.2302/kjm.abstract_72_1-2.abstractemerging infections are caused when microorganisms that are main
       
  • The Unlikely Development of CAR T Cells: a Brief History and Prospects for
           the Future

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: Keio J Med. 2023;72(1):26. doi: 10.2302/kjm.ABSTRACT_72_1-1.ABSTRACTThe quest to cure cancer has been one of the Holy Grails of medicine. The discovery I am going to share with you, CAR T cells, is a promising new form of therapy of cancer that offers the prospect of curing cancer using the immune system. CAR T cells are the first form of synthetic biology to enter the practice of medicine. The notion of using the immune system to fight cancer is an old idea. Over a century ago, bacteria were ground up and injected into patients with late-stage cancers, and occasionally the cancer would disappear. However, we now have precise tools for genetic editing and gene insertion like CRISPR/Cas9 to rewrite the DNA code, offering the possibility to improve the immune system over what has evolved in ...
      PubDate: Mon, 29 May 2023 01:46:04 +010
      DOI: 10.2302/kjm.abstract_72_1-1.abstractthe quest to cure cancer has been one of the holy grails of medi
       
  • Addressing the Threat of Emerging Viral Infections

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: Keio J Med. 2023;72(1):27. doi: 10.2302/kjm.ABSTRACT_72_1-2.ABSTRACTEmerging infections are caused when microorganisms that are maintained in a reservoir where they cause no harm, transmit from the reservoir to a new host. I have been studying the replication, molecular basis for pathogenesis, and host responses to emerging viruses, including influenza virus, Ebola virus, and SARS-CoV-2, and using the knowledge gained from these studies to develop antivirals and vaccines.Influenza viruses cause epidemics every winter, but occasionally new influenza viruses emerge and spread worldwide (pandemic). We established a technique that allows us to make influenza viruses artificially. This technique is now widely used for basic research and for the development of vaccines against highly pathogenic ...
      PubDate: Mon, 29 May 2023 01:46:04 +010
      DOI: 10.2302/kjm.abstract_72_1-2.abstractemerging infections are caused when microorganisms that are main
       
  • The Unlikely Development of CAR T Cells: a Brief History and Prospects for
           the Future

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: Keio J Med. 2023;72(1):26. doi: 10.2302/kjm.ABSTRACT_72_1-1.ABSTRACTThe quest to cure cancer has been one of the Holy Grails of medicine. The discovery I am going to share with you, CAR T cells, is a promising new form of therapy of cancer that offers the prospect of curing cancer using the immune system. CAR T cells are the first form of synthetic biology to enter the practice of medicine. The notion of using the immune system to fight cancer is an old idea. Over a century ago, bacteria were ground up and injected into patients with late-stage cancers, and occasionally the cancer would disappear. However, we now have precise tools for genetic editing and gene insertion like CRISPR/Cas9 to rewrite the DNA code, offering the possibility to improve the immune system over what has evolved in ...
      PubDate: Mon, 29 May 2023 01:46:04 +010
      DOI: 10.2302/kjm.abstract_72_1-1.abstractthe quest to cure cancer has been one of the holy grails of medi
       
  • Addressing the Threat of Emerging Viral Infections

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: Keio J Med. 2023;72(1):27. doi: 10.2302/kjm.ABSTRACT_72_1-2.ABSTRACTEmerging infections are caused when microorganisms that are maintained in a reservoir where they cause no harm, transmit from the reservoir to a new host. I have been studying the replication, molecular basis for pathogenesis, and host responses to emerging viruses, including influenza virus, Ebola virus, and SARS-CoV-2, and using the knowledge gained from these studies to develop antivirals and vaccines.Influenza viruses cause epidemics every winter, but occasionally new influenza viruses emerge and spread worldwide (pandemic). We established a technique that allows us to make influenza viruses artificially. This technique is now widely used for basic research and for the development of vaccines against highly pathogenic ...
      PubDate: Mon, 29 May 2023 01:46:04 +010
      DOI: 10.2302/kjm.abstract_72_1-2.abstractemerging infections are caused when microorganisms that are main
       
  • The Unlikely Development of CAR T Cells: a Brief History and Prospects for
           the Future

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: Keio J Med. 2023;72(1):26. doi: 10.2302/kjm.ABSTRACT_72_1-1.ABSTRACTThe quest to cure cancer has been one of the Holy Grails of medicine. The discovery I am going to share with you, CAR T cells, is a promising new form of therapy of cancer that offers the prospect of curing cancer using the immune system. CAR T cells are the first form of synthetic biology to enter the practice of medicine. The notion of using the immune system to fight cancer is an old idea. Over a century ago, bacteria were ground up and injected into patients with late-stage cancers, and occasionally the cancer would disappear. However, we now have precise tools for genetic editing and gene insertion like CRISPR/Cas9 to rewrite the DNA code, offering the possibility to improve the immune system over what has evolved in ...
      PubDate: Sun, 21 May 2023 12:33:02 +010
      DOI: 10.2302/kjm.abstract_72_1-1.abstractthe quest to cure cancer has been one of the holy grails of medi
       
  • Addressing the Threat of Emerging Viral Infections

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: Keio J Med. 2023;72(1):27. doi: 10.2302/kjm.ABSTRACT_72_1-2.ABSTRACTEmerging infections are caused when microorganisms that are maintained in a reservoir where they cause no harm, transmit from the reservoir to a new host. I have been studying the replication, molecular basis for pathogenesis, and host responses to emerging viruses, including influenza virus, Ebola virus, and SARS-CoV-2, and using the knowledge gained from these studies to develop antivirals and vaccines.Influenza viruses cause epidemics every winter, but occasionally new influenza viruses emerge and spread worldwide (pandemic). We established a technique that allows us to make influenza viruses artificially. This technique is now widely used for basic research and for the development of vaccines against highly pathogenic ...
      PubDate: Sun, 21 May 2023 12:33:02 +010
      DOI: 10.2302/kjm.abstract_72_1-2.abstractemerging infections are caused when microorganisms that are main
       
  • The Unlikely Development of CAR T Cells: a Brief History and Prospects for
           the Future

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: Keio J Med. 2023;72(1):26. doi: 10.2302/kjm.ABSTRACT_72_1-1.ABSTRACTThe quest to cure cancer has been one of the Holy Grails of medicine. The discovery I am going to share with you, CAR T cells, is a promising new form of therapy of cancer that offers the prospect of curing cancer using the immune system. CAR T cells are the first form of synthetic biology to enter the practice of medicine. The notion of using the immune system to fight cancer is an old idea. Over a century ago, bacteria were ground up and injected into patients with late-stage cancers, and occasionally the cancer would disappear. However, we now have precise tools for genetic editing and gene insertion like CRISPR/Cas9 to rewrite the DNA code, offering the possibility to improve the immune system over what has evolved in ...
      PubDate: Sun, 21 May 2023 12:33:02 +010
      DOI: 10.2302/kjm.abstract_72_1-1.abstractthe quest to cure cancer has been one of the holy grails of medi
       
  • Addressing the Threat of Emerging Viral Infections

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: Keio J Med. 2023;72(1):27. doi: 10.2302/kjm.ABSTRACT_72_1-2.ABSTRACTEmerging infections are caused when microorganisms that are maintained in a reservoir where they cause no harm, transmit from the reservoir to a new host. I have been studying the replication, molecular basis for pathogenesis, and host responses to emerging viruses, including influenza virus, Ebola virus, and SARS-CoV-2, and using the knowledge gained from these studies to develop antivirals and vaccines.Influenza viruses cause epidemics every winter, but occasionally new influenza viruses emerge and spread worldwide (pandemic). We established a technique that allows us to make influenza viruses artificially. This technique is now widely used for basic research and for the development of vaccines against highly pathogenic ...
      PubDate: Sun, 21 May 2023 12:33:02 +010
      DOI: 10.2302/kjm.abstract_72_1-2.abstractemerging infections are caused when microorganisms that are main
       
  • The Unlikely Development of CAR T Cells: a Brief History and Prospects for
           the Future

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: Keio J Med. 2023;72(1):26. doi: 10.2302/kjm.ABSTRACT_72_1-1.ABSTRACTThe quest to cure cancer has been one of the Holy Grails of medicine. The discovery I am going to share with you, CAR T cells, is a promising new form of therapy of cancer that offers the prospect of curing cancer using the immune system. CAR T cells are the first form of synthetic biology to enter the practice of medicine. The notion of using the immune system to fight cancer is an old idea. Over a century ago, bacteria were ground up and injected into patients with late-stage cancers, and occasionally the cancer would disappear. However, we now have precise tools for genetic editing and gene insertion like CRISPR/Cas9 to rewrite the DNA code, offering the possibility to improve the immune system over what has evolved in ...
      PubDate: Sun, 21 May 2023 12:33:02 +010
      DOI: 10.2302/kjm.abstract_72_1-1.abstractthe quest to cure cancer has been one of the holy grails of medi
       
  • Addressing the Threat of Emerging Viral Infections

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: Keio J Med. 2023;72(1):27. doi: 10.2302/kjm.ABSTRACT_72_1-2.ABSTRACTEmerging infections are caused when microorganisms that are maintained in a reservoir where they cause no harm, transmit from the reservoir to a new host. I have been studying the replication, molecular basis for pathogenesis, and host responses to emerging viruses, including influenza virus, Ebola virus, and SARS-CoV-2, and using the knowledge gained from these studies to develop antivirals and vaccines.Influenza viruses cause epidemics every winter, but occasionally new influenza viruses emerge and spread worldwide (pandemic). We established a technique that allows us to make influenza viruses artificially. This technique is now widely used for basic research and for the development of vaccines against highly pathogenic ...
      PubDate: Sun, 21 May 2023 12:33:02 +010
      DOI: 10.2302/kjm.abstract_72_1-2.abstractemerging infections are caused when microorganisms that are main
       
  • The Unlikely Development of CAR T Cells: a Brief History and Prospects for
           the Future

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: Keio J Med. 2023;72(1):26. doi: 10.2302/kjm.ABSTRACT_72_1-1.ABSTRACTThe quest to cure cancer has been one of the Holy Grails of medicine. The discovery I am going to share with you, CAR T cells, is a promising new form of therapy of cancer that offers the prospect of curing cancer using the immune system. CAR T cells are the first form of synthetic biology to enter the practice of medicine. The notion of using the immune system to fight cancer is an old idea. Over a century ago, bacteria were ground up and injected into patients with late-stage cancers, and occasionally the cancer would disappear. However, we now have precise tools for genetic editing and gene insertion like CRISPR/Cas9 to rewrite the DNA code, offering the possibility to improve the immune system over what has evolved in ...
      PubDate: Sun, 21 May 2023 12:33:02 +010
      DOI: 10.2302/kjm.abstract_72_1-1.abstractthe quest to cure cancer has been one of the holy grails of medi
       
  • Addressing the Threat of Emerging Viral Infections

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: Keio J Med. 2023;72(1):27. doi: 10.2302/kjm.ABSTRACT_72_1-2.ABSTRACTEmerging infections are caused when microorganisms that are maintained in a reservoir where they cause no harm, transmit from the reservoir to a new host. I have been studying the replication, molecular basis for pathogenesis, and host responses to emerging viruses, including influenza virus, Ebola virus, and SARS-CoV-2, and using the knowledge gained from these studies to develop antivirals and vaccines.Influenza viruses cause epidemics every winter, but occasionally new influenza viruses emerge and spread worldwide (pandemic). We established a technique that allows us to make influenza viruses artificially. This technique is now widely used for basic research and for the development of vaccines against highly pathogenic ...
      PubDate: Sun, 21 May 2023 12:33:02 +010
      DOI: 10.2302/kjm.abstract_72_1-2.abstractemerging infections are caused when microorganisms that are main
       
  • The Unlikely Development of CAR T Cells: a Brief History and Prospects for
           the Future

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: Keio J Med. 2023;72(1):26. doi: 10.2302/kjm.ABSTRACT_72_1-1.ABSTRACTThe quest to cure cancer has been one of the Holy Grails of medicine. The discovery I am going to share with you, CAR T cells, is a promising new form of therapy of cancer that offers the prospect of curing cancer using the immune system. CAR T cells are the first form of synthetic biology to enter the practice of medicine. The notion of using the immune system to fight cancer is an old idea. Over a century ago, bacteria were ground up and injected into patients with late-stage cancers, and occasionally the cancer would disappear. However, we now have precise tools for genetic editing and gene insertion like CRISPR/Cas9 to rewrite the DNA code, offering the possibility to improve the immune system over what has evolved in ...
      PubDate: Tue, 16 May 2023 18:01:40 +010
      DOI: 10.2302/kjm.abstract_72_1-1.abstractthe quest to cure cancer has been one of the holy grails of medi
       
  • Addressing the Threat of Emerging Viral Infections

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: Keio J Med. 2023;72(1):27. doi: 10.2302/kjm.ABSTRACT_72_1-2.ABSTRACTEmerging infections are caused when microorganisms that are maintained in a reservoir where they cause no harm, transmit from the reservoir to a new host. I have been studying the replication, molecular basis for pathogenesis, and host responses to emerging viruses, including influenza virus, Ebola virus, and SARS-CoV-2, and using the knowledge gained from these studies to develop antivirals and vaccines.Influenza viruses cause epidemics every winter, but occasionally new influenza viruses emerge and spread worldwide (pandemic). We established a technique that allows us to make influenza viruses artificially. This technique is now widely used for basic research and for the development of vaccines against highly pathogenic ...
      PubDate: Tue, 16 May 2023 18:01:40 +010
      DOI: 10.2302/kjm.abstract_72_1-2.abstractemerging infections are caused when microorganisms that are main
       
  • The Unlikely Development of CAR T Cells: a Brief History and Prospects for
           the Future

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: Keio J Med. 2023;72(1):26. doi: 10.2302/kjm.ABSTRACT_72_1-1.ABSTRACTThe quest to cure cancer has been one of the Holy Grails of medicine. The discovery I am going to share with you, CAR T cells, is a promising new form of therapy of cancer that offers the prospect of curing cancer using the immune system. CAR T cells are the first form of synthetic biology to enter the practice of medicine. The notion of using the immune system to fight cancer is an old idea. Over a century ago, bacteria were ground up and injected into patients with late-stage cancers, and occasionally the cancer would disappear. However, we now have precise tools for genetic editing and gene insertion like CRISPR/Cas9 to rewrite the DNA code, offering the possibility to improve the immune system over what has evolved in ...
      PubDate: Tue, 16 May 2023 18:01:40 +010
      DOI: 10.2302/kjm.abstract_72_1-1.abstractthe quest to cure cancer has been one of the holy grails of medi
       
  • Addressing the Threat of Emerging Viral Infections

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: Keio J Med. 2023;72(1):27. doi: 10.2302/kjm.ABSTRACT_72_1-2.ABSTRACTEmerging infections are caused when microorganisms that are maintained in a reservoir where they cause no harm, transmit from the reservoir to a new host. I have been studying the replication, molecular basis for pathogenesis, and host responses to emerging viruses, including influenza virus, Ebola virus, and SARS-CoV-2, and using the knowledge gained from these studies to develop antivirals and vaccines.Influenza viruses cause epidemics every winter, but occasionally new influenza viruses emerge and spread worldwide (pandemic). We established a technique that allows us to make influenza viruses artificially. This technique is now widely used for basic research and for the development of vaccines against highly pathogenic ...
      PubDate: Tue, 16 May 2023 18:01:40 +010
      DOI: 10.2302/kjm.abstract_72_1-2.abstractemerging infections are caused when microorganisms that are main
       
  • The Unlikely Development of CAR T Cells: a Brief History and Prospects for
           the Future

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: Keio J Med. 2023;72(1):26. doi: 10.2302/kjm.ABSTRACT_72_1-1.ABSTRACTThe quest to cure cancer has been one of the Holy Grails of medicine. The discovery I am going to share with you, CAR T cells, is a promising new form of therapy of cancer that offers the prospect of curing cancer using the immune system. CAR T cells are the first form of synthetic biology to enter the practice of medicine. The notion of using the immune system to fight cancer is an old idea. Over a century ago, bacteria were ground up and injected into patients with late-stage cancers, and occasionally the cancer would disappear. However, we now have precise tools for genetic editing and gene insertion like CRISPR/Cas9 to rewrite the DNA code, offering the possibility to improve the immune system over what has evolved in ...
      PubDate: Tue, 16 May 2023 18:01:40 +010
      DOI: 10.2302/kjm.abstract_72_1-1.abstractthe quest to cure cancer has been one of the holy grails of medi
       
  • Addressing the Threat of Emerging Viral Infections

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: Keio J Med. 2023;72(1):27. doi: 10.2302/kjm.ABSTRACT_72_1-2.ABSTRACTEmerging infections are caused when microorganisms that are maintained in a reservoir where they cause no harm, transmit from the reservoir to a new host. I have been studying the replication, molecular basis for pathogenesis, and host responses to emerging viruses, including influenza virus, Ebola virus, and SARS-CoV-2, and using the knowledge gained from these studies to develop antivirals and vaccines.Influenza viruses cause epidemics every winter, but occasionally new influenza viruses emerge and spread worldwide (pandemic). We established a technique that allows us to make influenza viruses artificially. This technique is now widely used for basic research and for the development of vaccines against highly pathogenic ...
      PubDate: Tue, 16 May 2023 18:01:40 +010
      DOI: 10.2302/kjm.abstract_72_1-2.abstractemerging infections are caused when microorganisms that are main
       
  • The Unlikely Development of CAR T Cells: a Brief History and Prospects for
           the Future

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: Keio J Med. 2023;72(1):26. doi: 10.2302/kjm.ABSTRACT_72_1-1.ABSTRACTThe quest to cure cancer has been one of the Holy Grails of medicine. The discovery I am going to share with you, CAR T cells, is a promising new form of therapy of cancer that offers the prospect of curing cancer using the immune system. CAR T cells are the first form of synthetic biology to enter the practice of medicine. The notion of using the immune system to fight cancer is an old idea. Over a century ago, bacteria were ground up and injected into patients with late-stage cancers, and occasionally the cancer would disappear. However, we now have precise tools for genetic editing and gene insertion like CRISPR/Cas9 to rewrite the DNA code, offering the possibility to improve the immune system over what has evolved in ...
      PubDate: Tue, 16 May 2023 18:01:40 +010
      DOI: 10.2302/kjm.abstract_72_1-1.abstractthe quest to cure cancer has been one of the holy grails of medi
       
  • Addressing the Threat of Emerging Viral Infections

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: Keio J Med. 2023;72(1):27. doi: 10.2302/kjm.ABSTRACT_72_1-2.ABSTRACTEmerging infections are caused when microorganisms that are maintained in a reservoir where they cause no harm, transmit from the reservoir to a new host. I have been studying the replication, molecular basis for pathogenesis, and host responses to emerging viruses, including influenza virus, Ebola virus, and SARS-CoV-2, and using the knowledge gained from these studies to develop antivirals and vaccines.Influenza viruses cause epidemics every winter, but occasionally new influenza viruses emerge and spread worldwide (pandemic). We established a technique that allows us to make influenza viruses artificially. This technique is now widely used for basic research and for the development of vaccines against highly pathogenic ...
      PubDate: Tue, 16 May 2023 18:01:40 +010
      DOI: 10.2302/kjm.abstract_72_1-2.abstractemerging infections are caused when microorganisms that are main
       
  • The Unlikely Development of CAR T Cells: a Brief History and Prospects for
           the Future

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: Keio J Med. 2023;72(1):26. doi: 10.2302/kjm.ABSTRACT_72_1-1.ABSTRACTThe quest to cure cancer has been one of the Holy Grails of medicine. The discovery I am going to share with you, CAR T cells, is a promising new form of therapy of cancer that offers the prospect of curing cancer using the immune system. CAR T cells are the first form of synthetic biology to enter the practice of medicine. The notion of using the immune system to fight cancer is an old idea. Over a century ago, bacteria were ground up and injected into patients with late-stage cancers, and occasionally the cancer would disappear. However, we now have precise tools for genetic editing and gene insertion like CRISPR/Cas9 to rewrite the DNA code, offering the possibility to improve the immune system over what has evolved in ...
      PubDate: Wed, 10 May 2023 22:15:06 +010
      DOI: 10.2302/kjm.abstract_72_1-1.abstractthe quest to cure cancer has been one of the holy grails of medi
       
  • Addressing the Threat of Emerging Viral Infections

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: Keio J Med. 2023;72(1):27. doi: 10.2302/kjm.ABSTRACT_72_1-2.ABSTRACTEmerging infections are caused when microorganisms that are maintained in a reservoir where they cause no harm, transmit from the reservoir to a new host. I have been studying the replication, molecular basis for pathogenesis, and host responses to emerging viruses, including influenza virus, Ebola virus, and SARS-CoV-2, and using the knowledge gained from these studies to develop antivirals and vaccines.Influenza viruses cause epidemics every winter, but occasionally new influenza viruses emerge and spread worldwide (pandemic). We established a technique that allows us to make influenza viruses artificially. This technique is now widely used for basic research and for the development of vaccines against highly pathogenic ...
      PubDate: Wed, 10 May 2023 22:15:06 +010
      DOI: 10.2302/kjm.abstract_72_1-2.abstractemerging infections are caused when microorganisms that are main
       
  • The Unlikely Development of CAR T Cells: a Brief History and Prospects for
           the Future

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: Keio J Med. 2023;72(1):26. doi: 10.2302/kjm.ABSTRACT_72_1-1.ABSTRACTThe quest to cure cancer has been one of the Holy Grails of medicine. The discovery I am going to share with you, CAR T cells, is a promising new form of therapy of cancer that offers the prospect of curing cancer using the immune system. CAR T cells are the first form of synthetic biology to enter the practice of medicine. The notion of using the immune system to fight cancer is an old idea. Over a century ago, bacteria were ground up and injected into patients with late-stage cancers, and occasionally the cancer would disappear. However, we now have precise tools for genetic editing and gene insertion like CRISPR/Cas9 to rewrite the DNA code, offering the possibility to improve the immune system over what has evolved in ...
      PubDate: Wed, 10 May 2023 22:15:06 +010
      DOI: 10.2302/kjm.abstract_72_1-1.abstractthe quest to cure cancer has been one of the holy grails of medi
       
  • Addressing the Threat of Emerging Viral Infections

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: Keio J Med. 2023;72(1):27. doi: 10.2302/kjm.ABSTRACT_72_1-2.ABSTRACTEmerging infections are caused when microorganisms that are maintained in a reservoir where they cause no harm, transmit from the reservoir to a new host. I have been studying the replication, molecular basis for pathogenesis, and host responses to emerging viruses, including influenza virus, Ebola virus, and SARS-CoV-2, and using the knowledge gained from these studies to develop antivirals and vaccines.Influenza viruses cause epidemics every winter, but occasionally new influenza viruses emerge and spread worldwide (pandemic). We established a technique that allows us to make influenza viruses artificially. This technique is now widely used for basic research and for the development of vaccines against highly pathogenic ...
      PubDate: Wed, 10 May 2023 22:15:06 +010
      DOI: 10.2302/kjm.abstract_72_1-2.abstractemerging infections are caused when microorganisms that are main
       
  • The Unlikely Development of CAR T Cells: a Brief History and Prospects for
           the Future

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: Keio J Med. 2023;72(1):26. doi: 10.2302/kjm.ABSTRACT_72_1-1.ABSTRACTThe quest to cure cancer has been one of the Holy Grails of medicine. The discovery I am going to share with you, CAR T cells, is a promising new form of therapy of cancer that offers the prospect of curing cancer using the immune system. CAR T cells are the first form of synthetic biology to enter the practice of medicine. The notion of using the immune system to fight cancer is an old idea. Over a century ago, bacteria were ground up and injected into patients with late-stage cancers, and occasionally the cancer would disappear. However, we now have precise tools for genetic editing and gene insertion like CRISPR/Cas9 to rewrite the DNA code, offering the possibility to improve the immune system over what has evolved in ...
      PubDate: Wed, 10 May 2023 22:15:06 +010
      DOI: 10.2302/kjm.abstract_72_1-1.abstractthe quest to cure cancer has been one of the holy grails of medi
       
  • Addressing the Threat of Emerging Viral Infections

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: Keio J Med. 2023;72(1):27. doi: 10.2302/kjm.ABSTRACT_72_1-2.ABSTRACTEmerging infections are caused when microorganisms that are maintained in a reservoir where they cause no harm, transmit from the reservoir to a new host. I have been studying the replication, molecular basis for pathogenesis, and host responses to emerging viruses, including influenza virus, Ebola virus, and SARS-CoV-2, and using the knowledge gained from these studies to develop antivirals and vaccines.Influenza viruses cause epidemics every winter, but occasionally new influenza viruses emerge and spread worldwide (pandemic). We established a technique that allows us to make influenza viruses artificially. This technique is now widely used for basic research and for the development of vaccines against highly pathogenic ...
      PubDate: Wed, 10 May 2023 22:15:06 +010
      DOI: 10.2302/kjm.abstract_72_1-2.abstractemerging infections are caused when microorganisms that are main
       
  • The Unlikely Development of CAR T Cells: a Brief History and Prospects for
           the Future

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: Keio J Med. 2023;72(1):26. doi: 10.2302/kjm.ABSTRACT_72_1-1.ABSTRACTThe quest to cure cancer has been one of the Holy Grails of medicine. The discovery I am going to share with you, CAR T cells, is a promising new form of therapy of cancer that offers the prospect of curing cancer using the immune system. CAR T cells are the first form of synthetic biology to enter the practice of medicine. The notion of using the immune system to fight cancer is an old idea. Over a century ago, bacteria were ground up and injected into patients with late-stage cancers, and occasionally the cancer would disappear. However, we now have precise tools for genetic editing and gene insertion like CRISPR/Cas9 to rewrite the DNA code, offering the possibility to improve the immune system over what has evolved in ...
      PubDate: Wed, 10 May 2023 22:15:06 +010
      DOI: 10.2302/kjm.abstract_72_1-1.abstractthe quest to cure cancer has been one of the holy grails of medi
       
  • Addressing the Threat of Emerging Viral Infections

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: Keio J Med. 2023;72(1):27. doi: 10.2302/kjm.ABSTRACT_72_1-2.ABSTRACTEmerging infections are caused when microorganisms that are maintained in a reservoir where they cause no harm, transmit from the reservoir to a new host. I have been studying the replication, molecular basis for pathogenesis, and host responses to emerging viruses, including influenza virus, Ebola virus, and SARS-CoV-2, and using the knowledge gained from these studies to develop antivirals and vaccines.Influenza viruses cause epidemics every winter, but occasionally new influenza viruses emerge and spread worldwide (pandemic). We established a technique that allows us to make influenza viruses artificially. This technique is now widely used for basic research and for the development of vaccines against highly pathogenic ...
      PubDate: Wed, 10 May 2023 22:15:06 +010
      DOI: 10.2302/kjm.abstract_72_1-2.abstractemerging infections are caused when microorganisms that are main
       
  • The Unlikely Development of CAR T Cells: a Brief History and Prospects for
           the Future

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: Keio J Med. 2023;72(1):26. doi: 10.2302/kjm.ABSTRACT_72_1-1.ABSTRACTThe quest to cure cancer has been one of the Holy Grails of medicine. The discovery I am going to share with you, CAR T cells, is a promising new form of therapy of cancer that offers the prospect of curing cancer using the immune system. CAR T cells are the first form of synthetic biology to enter the practice of medicine. The notion of using the immune system to fight cancer is an old idea. Over a century ago, bacteria were ground up and injected into patients with late-stage cancers, and occasionally the cancer would disappear. However, we now have precise tools for genetic editing and gene insertion like CRISPR/Cas9 to rewrite the DNA code, offering the possibility to improve the immune system over what has evolved in ...
      PubDate: Thu, 04 May 2023 04:45:51 +010
      DOI: 10.2302/kjm.abstract_72_1-1.abstractthe quest to cure cancer has been one of the holy grails of medi
       
  • Addressing the Threat of Emerging Viral Infections

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: Keio J Med. 2023;72(1):27. doi: 10.2302/kjm.ABSTRACT_72_1-2.ABSTRACTEmerging infections are caused when microorganisms that are maintained in a reservoir where they cause no harm, transmit from the reservoir to a new host. I have been studying the replication, molecular basis for pathogenesis, and host responses to emerging viruses, including influenza virus, Ebola virus, and SARS-CoV-2, and using the knowledge gained from these studies to develop antivirals and vaccines.Influenza viruses cause epidemics every winter, but occasionally new influenza viruses emerge and spread worldwide (pandemic). We established a technique that allows us to make influenza viruses artificially. This technique is now widely used for basic research and for the development of vaccines against highly pathogenic ...
      PubDate: Thu, 04 May 2023 04:45:51 +010
      DOI: 10.2302/kjm.abstract_72_1-2.abstractemerging infections are caused when microorganisms that are main
       
  • The Unlikely Development of CAR T Cells: a Brief History and Prospects for
           the Future

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: Keio J Med. 2023;72(1):26. doi: 10.2302/kjm.ABSTRACT_72_1-1.ABSTRACTThe quest to cure cancer has been one of the Holy Grails of medicine. The discovery I am going to share with you, CAR T cells, is a promising new form of therapy of cancer that offers the prospect of curing cancer using the immune system. CAR T cells are the first form of synthetic biology to enter the practice of medicine. The notion of using the immune system to fight cancer is an old idea. Over a century ago, bacteria were ground up and injected into patients with late-stage cancers, and occasionally the cancer would disappear. However, we now have precise tools for genetic editing and gene insertion like CRISPR/Cas9 to rewrite the DNA code, offering the possibility to improve the immune system over what has evolved in ...
      PubDate: Thu, 04 May 2023 04:45:51 +010
      DOI: 10.2302/kjm.abstract_72_1-1.abstractthe quest to cure cancer has been one of the holy grails of medi
       
  • Addressing the Threat of Emerging Viral Infections

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: Keio J Med. 2023;72(1):27. doi: 10.2302/kjm.ABSTRACT_72_1-2.ABSTRACTEmerging infections are caused when microorganisms that are maintained in a reservoir where they cause no harm, transmit from the reservoir to a new host. I have been studying the replication, molecular basis for pathogenesis, and host responses to emerging viruses, including influenza virus, Ebola virus, and SARS-CoV-2, and using the knowledge gained from these studies to develop antivirals and vaccines.Influenza viruses cause epidemics every winter, but occasionally new influenza viruses emerge and spread worldwide (pandemic). We established a technique that allows us to make influenza viruses artificially. This technique is now widely used for basic research and for the development of vaccines against highly pathogenic ...
      PubDate: Thu, 04 May 2023 04:45:51 +010
      DOI: 10.2302/kjm.abstract_72_1-2.abstractemerging infections are caused when microorganisms that are main
       
  • The Unlikely Development of CAR T Cells: a Brief History and Prospects for
           the Future

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: Keio J Med. 2023;72(1):26. doi: 10.2302/kjm.ABSTRACT_72_1-1.ABSTRACTThe quest to cure cancer has been one of the Holy Grails of medicine. The discovery I am going to share with you, CAR T cells, is a promising new form of therapy of cancer that offers the prospect of curing cancer using the immune system. CAR T cells are the first form of synthetic biology to enter the practice of medicine. The notion of using the immune system to fight cancer is an old idea. Over a century ago, bacteria were ground up and injected into patients with late-stage cancers, and occasionally the cancer would disappear. However, we now have precise tools for genetic editing and gene insertion like CRISPR/Cas9 to rewrite the DNA code, offering the possibility to improve the immune system over what has evolved in ...
      PubDate: Thu, 04 May 2023 04:45:51 +010
      DOI: 10.2302/kjm.abstract_72_1-1.abstractthe quest to cure cancer has been one of the holy grails of medi
       
  • Addressing the Threat of Emerging Viral Infections

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: Keio J Med. 2023;72(1):27. doi: 10.2302/kjm.ABSTRACT_72_1-2.ABSTRACTEmerging infections are caused when microorganisms that are maintained in a reservoir where they cause no harm, transmit from the reservoir to a new host. I have been studying the replication, molecular basis for pathogenesis, and host responses to emerging viruses, including influenza virus, Ebola virus, and SARS-CoV-2, and using the knowledge gained from these studies to develop antivirals and vaccines.Influenza viruses cause epidemics every winter, but occasionally new influenza viruses emerge and spread worldwide (pandemic). We established a technique that allows us to make influenza viruses artificially. This technique is now widely used for basic research and for the development of vaccines against highly pathogenic ...
      PubDate: Thu, 04 May 2023 04:45:51 +010
      DOI: 10.2302/kjm.abstract_72_1-2.abstractemerging infections are caused when microorganisms that are main
       
  • The Unlikely Development of CAR T Cells: a Brief History and Prospects for
           the Future

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: Keio J Med. 2023;72(1):26. doi: 10.2302/kjm.ABSTRACT_72_1-1.ABSTRACTThe quest to cure cancer has been one of the Holy Grails of medicine. The discovery I am going to share with you, CAR T cells, is a promising new form of therapy of cancer that offers the prospect of curing cancer using the immune system. CAR T cells are the first form of synthetic biology to enter the practice of medicine. The notion of using the immune system to fight cancer is an old idea. Over a century ago, bacteria were ground up and injected into patients with late-stage cancers, and occasionally the cancer would disappear. However, we now have precise tools for genetic editing and gene insertion like CRISPR/Cas9 to rewrite the DNA code, offering the possibility to improve the immune system over what has evolved in ...
      PubDate: Thu, 04 May 2023 04:45:51 +010
      DOI: 10.2302/kjm.abstract_72_1-1.abstractthe quest to cure cancer has been one of the holy grails of medi
       
  • Addressing the Threat of Emerging Viral Infections

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: Keio J Med. 2023;72(1):27. doi: 10.2302/kjm.ABSTRACT_72_1-2.ABSTRACTEmerging infections are caused when microorganisms that are maintained in a reservoir where they cause no harm, transmit from the reservoir to a new host. I have been studying the replication, molecular basis for pathogenesis, and host responses to emerging viruses, including influenza virus, Ebola virus, and SARS-CoV-2, and using the knowledge gained from these studies to develop antivirals and vaccines.Influenza viruses cause epidemics every winter, but occasionally new influenza viruses emerge and spread worldwide (pandemic). We established a technique that allows us to make influenza viruses artificially. This technique is now widely used for basic research and for the development of vaccines against highly pathogenic ...
      PubDate: Thu, 04 May 2023 04:45:51 +010
      DOI: 10.2302/kjm.abstract_72_1-2.abstractemerging infections are caused when microorganisms that are main
       
  • The Unlikely Development of CAR T Cells: a Brief History and Prospects for
           the Future

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: Keio J Med. 2023;72(1):26. doi: 10.2302/kjm.ABSTRACT_72_1-1.ABSTRACTThe quest to cure cancer has been one of the Holy Grails of medicine. The discovery I am going to share with you, CAR T cells, is a promising new form of therapy of cancer that offers the prospect of curing cancer using the immune system. CAR T cells are the first form of synthetic biology to enter the practice of medicine. The notion of using the immune system to fight cancer is an old idea. Over a century ago, bacteria were ground up and injected into patients with late-stage cancers, and occasionally the cancer would disappear. However, we now have precise tools for genetic editing and gene insertion like CRISPR/Cas9 to rewrite the DNA code, offering the possibility to improve the immune system over what has evolved in ...
      PubDate: Thu, 04 May 2023 04:45:51 +010
      DOI: 10.2302/kjm.abstract_72_1-1.abstractthe quest to cure cancer has been one of the holy grails of medi
       
  • Addressing the Threat of Emerging Viral Infections

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: Keio J Med. 2023;72(1):27. doi: 10.2302/kjm.ABSTRACT_72_1-2.ABSTRACTEmerging infections are caused when microorganisms that are maintained in a reservoir where they cause no harm, transmit from the reservoir to a new host. I have been studying the replication, molecular basis for pathogenesis, and host responses to emerging viruses, including influenza virus, Ebola virus, and SARS-CoV-2, and using the knowledge gained from these studies to develop antivirals and vaccines.Influenza viruses cause epidemics every winter, but occasionally new influenza viruses emerge and spread worldwide (pandemic). We established a technique that allows us to make influenza viruses artificially. This technique is now widely used for basic research and for the development of vaccines against highly pathogenic ...
      PubDate: Thu, 04 May 2023 04:45:51 +010
      DOI: 10.2302/kjm.abstract_72_1-2.abstractemerging infections are caused when microorganisms that are main
       
  • The Unlikely Development of CAR T Cells: a Brief History and Prospects for
           the Future

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: Keio J Med. 2023;72(1):26. doi: 10.2302/kjm.ABSTRACT_72_1-1.ABSTRACTThe quest to cure cancer has been one of the Holy Grails of medicine. The discovery I am going to share with you, CAR T cells, is a promising new form of therapy of cancer that offers the prospect of curing cancer using the immune system. CAR T cells are the first form of synthetic biology to enter the practice of medicine. The notion of using the immune system to fight cancer is an old idea. Over a century ago, bacteria were ground up and injected into patients with late-stage cancers, and occasionally the cancer would disappear. However, we now have precise tools for genetic editing and gene insertion like CRISPR/Cas9 to rewrite the DNA code, offering the possibility to improve the immune system over what has evolved in ...
      PubDate: Thu, 27 Apr 2023 01:19:30 +010
      DOI: 10.2302/kjm.abstract_72_1-1.abstractthe quest to cure cancer has been one of the holy grails of medi
       
  • Addressing the Threat of Emerging Viral Infections

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: Keio J Med. 2023;72(1):27. doi: 10.2302/kjm.ABSTRACT_72_1-2.ABSTRACTEmerging infections are caused when microorganisms that are maintained in a reservoir where they cause no harm, transmit from the reservoir to a new host. I have been studying the replication, molecular basis for pathogenesis, and host responses to emerging viruses, including influenza virus, Ebola virus, and SARS-CoV-2, and using the knowledge gained from these studies to develop antivirals and vaccines.Influenza viruses cause epidemics every winter, but occasionally new influenza viruses emerge and spread worldwide (pandemic). We established a technique that allows us to make influenza viruses artificially. This technique is now widely used for basic research and for the development of vaccines against highly pathogenic ...
      PubDate: Thu, 27 Apr 2023 01:19:30 +010
      DOI: 10.2302/kjm.abstract_72_1-2.abstractemerging infections are caused when microorganisms that are main
       
  • The Unlikely Development of CAR T Cells: a Brief History and Prospects for
           the Future

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: Keio J Med. 2023;72(1):26. doi: 10.2302/kjm.ABSTRACT_72_1-1.ABSTRACTThe quest to cure cancer has been one of the Holy Grails of medicine. The discovery I am going to share with you, CAR T cells, is a promising new form of therapy of cancer that offers the prospect of curing cancer using the immune system. CAR T cells are the first form of synthetic biology to enter the practice of medicine. The notion of using the immune system to fight cancer is an old idea. Over a century ago, bacteria were ground up and injected into patients with late-stage cancers, and occasionally the cancer would disappear. However, we now have precise tools for genetic editing and gene insertion like CRISPR/Cas9 to rewrite the DNA code, offering the possibility to improve the immune system over what has evolved in ...
      PubDate: Thu, 27 Apr 2023 01:19:30 +010
      DOI: 10.2302/kjm.abstract_72_1-1.abstractthe quest to cure cancer has been one of the holy grails of medi
       
  • Addressing the Threat of Emerging Viral Infections

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: Keio J Med. 2023;72(1):27. doi: 10.2302/kjm.ABSTRACT_72_1-2.ABSTRACTEmerging infections are caused when microorganisms that are maintained in a reservoir where they cause no harm, transmit from the reservoir to a new host. I have been studying the replication, molecular basis for pathogenesis, and host responses to emerging viruses, including influenza virus, Ebola virus, and SARS-CoV-2, and using the knowledge gained from these studies to develop antivirals and vaccines.Influenza viruses cause epidemics every winter, but occasionally new influenza viruses emerge and spread worldwide (pandemic). We established a technique that allows us to make influenza viruses artificially. This technique is now widely used for basic research and for the development of vaccines against highly pathogenic ...
      PubDate: Thu, 27 Apr 2023 01:19:30 +010
      DOI: 10.2302/kjm.abstract_72_1-2.abstractemerging infections are caused when microorganisms that are main
       
  • The Unlikely Development of CAR T Cells: a Brief History and Prospects for
           the Future

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: Keio J Med. 2023;72(1):26. doi: 10.2302/kjm.ABSTRACT_72_1-1.ABSTRACTThe quest to cure cancer has been one of the Holy Grails of medicine. The discovery I am going to share with you, CAR T cells, is a promising new form of therapy of cancer that offers the prospect of curing cancer using the immune system. CAR T cells are the first form of synthetic biology to enter the practice of medicine. The notion of using the immune system to fight cancer is an old idea. Over a century ago, bacteria were ground up and injected into patients with late-stage cancers, and occasionally the cancer would disappear. However, we now have precise tools for genetic editing and gene insertion like CRISPR/Cas9 to rewrite the DNA code, offering the possibility to improve the immune system over what has evolved in ...
      PubDate: Thu, 27 Apr 2023 01:19:30 +010
      DOI: 10.2302/kjm.abstract_72_1-1.abstractthe quest to cure cancer has been one of the holy grails of medi
       
  • Addressing the Threat of Emerging Viral Infections

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: Keio J Med. 2023;72(1):27. doi: 10.2302/kjm.ABSTRACT_72_1-2.ABSTRACTEmerging infections are caused when microorganisms that are maintained in a reservoir where they cause no harm, transmit from the reservoir to a new host. I have been studying the replication, molecular basis for pathogenesis, and host responses to emerging viruses, including influenza virus, Ebola virus, and SARS-CoV-2, and using the knowledge gained from these studies to develop antivirals and vaccines.Influenza viruses cause epidemics every winter, but occasionally new influenza viruses emerge and spread worldwide (pandemic). We established a technique that allows us to make influenza viruses artificially. This technique is now widely used for basic research and for the development of vaccines against highly pathogenic ...
      PubDate: Thu, 27 Apr 2023 01:19:30 +010
      DOI: 10.2302/kjm.abstract_72_1-2.abstractemerging infections are caused when microorganisms that are main
       
  • The Unlikely Development of CAR T Cells: a Brief History and Prospects for
           the Future

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: Keio J Med. 2023;72(1):26. doi: 10.2302/kjm.ABSTRACT_72_1-1.ABSTRACTThe quest to cure cancer has been one of the Holy Grails of medicine. The discovery I am going to share with you, CAR T cells, is a promising new form of therapy of cancer that offers the prospect of curing cancer using the immune system. CAR T cells are the first form of synthetic biology to enter the practice of medicine. The notion of using the immune system to fight cancer is an old idea. Over a century ago, bacteria were ground up and injected into patients with late-stage cancers, and occasionally the cancer would disappear. However, we now have precise tools for genetic editing and gene insertion like CRISPR/Cas9 to rewrite the DNA code, offering the possibility to improve the immune system over what has evolved in ...
      PubDate: Sun, 23 Apr 2023 09:38:07 +010
      DOI: 10.2302/kjm.abstract_72_1-1.abstractthe quest to cure cancer has been one of the holy grails of medi
       
  • Addressing the Threat of Emerging Viral Infections

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: Keio J Med. 2023;72(1):27. doi: 10.2302/kjm.ABSTRACT_72_1-2.ABSTRACTEmerging infections are caused when microorganisms that are maintained in a reservoir where they cause no harm, transmit from the reservoir to a new host. I have been studying the replication, molecular basis for pathogenesis, and host responses to emerging viruses, including influenza virus, Ebola virus, and SARS-CoV-2, and using the knowledge gained from these studies to develop antivirals and vaccines.Influenza viruses cause epidemics every winter, but occasionally new influenza viruses emerge and spread worldwide (pandemic). We established a technique that allows us to make influenza viruses artificially. This technique is now widely used for basic research and for the development of vaccines against highly pathogenic ...
      PubDate: Sun, 23 Apr 2023 09:38:07 +010
      DOI: 10.2302/kjm.abstract_72_1-2.abstractemerging infections are caused when microorganisms that are main
       
  • The Unlikely Development of CAR T Cells: a Brief History and Prospects for
           the Future

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: Keio J Med. 2023;72(1):26. doi: 10.2302/kjm.ABSTRACT_72_1-1.ABSTRACTThe quest to cure cancer has been one of the Holy Grails of medicine. The discovery I am going to share with you, CAR T cells, is a promising new form of therapy of cancer that offers the prospect of curing cancer using the immune system. CAR T cells are the first form of synthetic biology to enter the practice of medicine. The notion of using the immune system to fight cancer is an old idea. Over a century ago, bacteria were ground up and injected into patients with late-stage cancers, and occasionally the cancer would disappear. However, we now have precise tools for genetic editing and gene insertion like CRISPR/Cas9 to rewrite the DNA code, offering the possibility to improve the immune system over what has evolved in ...
      PubDate: Sun, 23 Apr 2023 09:38:07 +010
      DOI: 10.2302/kjm.abstract_72_1-1.abstractthe quest to cure cancer has been one of the holy grails of medi
       
  • Addressing the Threat of Emerging Viral Infections

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: Keio J Med. 2023;72(1):27. doi: 10.2302/kjm.ABSTRACT_72_1-2.ABSTRACTEmerging infections are caused when microorganisms that are maintained in a reservoir where they cause no harm, transmit from the reservoir to a new host. I have been studying the replication, molecular basis for pathogenesis, and host responses to emerging viruses, including influenza virus, Ebola virus, and SARS-CoV-2, and using the knowledge gained from these studies to develop antivirals and vaccines.Influenza viruses cause epidemics every winter, but occasionally new influenza viruses emerge and spread worldwide (pandemic). We established a technique that allows us to make influenza viruses artificially. This technique is now widely used for basic research and for the development of vaccines against highly pathogenic ...
      PubDate: Sun, 23 Apr 2023 09:38:07 +010
      DOI: 10.2302/kjm.abstract_72_1-2.abstractemerging infections are caused when microorganisms that are main
       
  • The Unlikely Development of CAR T Cells: a Brief History and Prospects for
           the Future

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: Keio J Med. 2023;72(1):26. doi: 10.2302/kjm.ABSTRACT_72_1-1.ABSTRACTThe quest to cure cancer has been one of the Holy Grails of medicine. The discovery I am going to share with you, CAR T cells, is a promising new form of therapy of cancer that offers the prospect of curing cancer using the immune system. CAR T cells are the first form of synthetic biology to enter the practice of medicine. The notion of using the immune system to fight cancer is an old idea. Over a century ago, bacteria were ground up and injected into patients with late-stage cancers, and occasionally the cancer would disappear. However, we now have precise tools for genetic editing and gene insertion like CRISPR/Cas9 to rewrite the DNA code, offering the possibility to improve the immune system over what has evolved in ...
      PubDate: Sun, 23 Apr 2023 09:38:07 +010
      DOI: 10.2302/kjm.abstract_72_1-1.abstractthe quest to cure cancer has been one of the holy grails of medi
       
  • Addressing the Threat of Emerging Viral Infections

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: Keio J Med. 2023;72(1):27. doi: 10.2302/kjm.ABSTRACT_72_1-2.ABSTRACTEmerging infections are caused when microorganisms that are maintained in a reservoir where they cause no harm, transmit from the reservoir to a new host. I have been studying the replication, molecular basis for pathogenesis, and host responses to emerging viruses, including influenza virus, Ebola virus, and SARS-CoV-2, and using the knowledge gained from these studies to develop antivirals and vaccines.Influenza viruses cause epidemics every winter, but occasionally new influenza viruses emerge and spread worldwide (pandemic). We established a technique that allows us to make influenza viruses artificially. This technique is now widely used for basic research and for the development of vaccines against highly pathogenic ...
      PubDate: Sun, 23 Apr 2023 09:38:07 +010
      DOI: 10.2302/kjm.abstract_72_1-2.abstractemerging infections are caused when microorganisms that are main
       
  • The Unlikely Development of CAR T Cells: a Brief History and Prospects for
           the Future

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: Keio J Med. 2023;72(1):26. doi: 10.2302/kjm.ABSTRACT_72_1-1.ABSTRACTThe quest to cure cancer has been one of the Holy Grails of medicine. The discovery I am going to share with you, CAR T cells, is a promising new form of therapy of cancer that offers the prospect of curing cancer using the immune system. CAR T cells are the first form of synthetic biology to enter the practice of medicine. The notion of using the immune system to fight cancer is an old idea. Over a century ago, bacteria were ground up and injected into patients with late-stage cancers, and occasionally the cancer would disappear. However, we now have precise tools for genetic editing and gene insertion like CRISPR/Cas9 to rewrite the DNA code, offering the possibility to improve the immune system over what has evolved in ...
      PubDate: Sun, 23 Apr 2023 09:38:07 +010
      DOI: 10.2302/kjm.abstract_72_1-1.abstractthe quest to cure cancer has been one of the holy grails of medi
       
  • Addressing the Threat of Emerging Viral Infections

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: Keio J Med. 2023;72(1):27. doi: 10.2302/kjm.ABSTRACT_72_1-2.ABSTRACTEmerging infections are caused when microorganisms that are maintained in a reservoir where they cause no harm, transmit from the reservoir to a new host. I have been studying the replication, molecular basis for pathogenesis, and host responses to emerging viruses, including influenza virus, Ebola virus, and SARS-CoV-2, and using the knowledge gained from these studies to develop antivirals and vaccines.Influenza viruses cause epidemics every winter, but occasionally new influenza viruses emerge and spread worldwide (pandemic). We established a technique that allows us to make influenza viruses artificially. This technique is now widely used for basic research and for the development of vaccines against highly pathogenic ...
      PubDate: Sun, 23 Apr 2023 09:38:07 +010
      DOI: 10.2302/kjm.abstract_72_1-2.abstractemerging infections are caused when microorganisms that are main
       
  • The Unlikely Development of CAR T Cells: a Brief History and Prospects for
           the Future

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: Keio J Med. 2023;72(1):26. doi: 10.2302/kjm.ABSTRACT_72_1-1.ABSTRACTThe quest to cure cancer has been one of the Holy Grails of medicine. The discovery I am going to share with you, CAR T cells, is a promising new form of therapy of cancer that offers the prospect of curing cancer using the immune system. CAR T cells are the first form of synthetic biology to enter the practice of medicine. The notion of using the immune system to fight cancer is an old idea. Over a century ago, bacteria were ground up and injected into patients with late-stage cancers, and occasionally the cancer would disappear. However, we now have precise tools for genetic editing and gene insertion like CRISPR/Cas9 to rewrite the DNA code, offering the possibility to improve the immune system over what has evolved in ...
      PubDate: Sun, 23 Apr 2023 09:38:07 +010
      DOI: 10.2302/kjm.abstract_72_1-1.abstractthe quest to cure cancer has been one of the holy grails of medi
       
  • Addressing the Threat of Emerging Viral Infections

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: Keio J Med. 2023;72(1):27. doi: 10.2302/kjm.ABSTRACT_72_1-2.ABSTRACTEmerging infections are caused when microorganisms that are maintained in a reservoir where they cause no harm, transmit from the reservoir to a new host. I have been studying the replication, molecular basis for pathogenesis, and host responses to emerging viruses, including influenza virus, Ebola virus, and SARS-CoV-2, and using the knowledge gained from these studies to develop antivirals and vaccines.Influenza viruses cause epidemics every winter, but occasionally new influenza viruses emerge and spread worldwide (pandemic). We established a technique that allows us to make influenza viruses artificially. This technique is now widely used for basic research and for the development of vaccines against highly pathogenic ...
      PubDate: Sun, 23 Apr 2023 09:38:07 +010
      DOI: 10.2302/kjm.abstract_72_1-2.abstractemerging infections are caused when microorganisms that are main
       
  • The Unlikely Development of CAR T Cells: a Brief History and Prospects for
           the Future

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: Keio J Med. 2023;72(1):26. doi: 10.2302/kjm.ABSTRACT_72_1-1.ABSTRACTThe quest to cure cancer has been one of the Holy Grails of medicine. The discovery I am going to share with you, CAR T cells, is a promising new form of therapy of cancer that offers the prospect of curing cancer using the immune system. CAR T cells are the first form of synthetic biology to enter the practice of medicine. The notion of using the immune system to fight cancer is an old idea. Over a century ago, bacteria were ground up and injected into patients with late-stage cancers, and occasionally the cancer would disappear. However, we now have precise tools for genetic editing and gene insertion like CRISPR/Cas9 to rewrite the DNA code, offering the possibility to improve the immune system over what has evolved in ...
      PubDate: Sun, 16 Apr 2023 01:54:08 +010
      DOI: 10.2302/kjm.abstract_72_1-1.abstractthe quest to cure cancer has been one of the holy grails of medi
       
  • Addressing the Threat of Emerging Viral Infections

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: Keio J Med. 2023;72(1):27. doi: 10.2302/kjm.ABSTRACT_72_1-2.ABSTRACTEmerging infections are caused when microorganisms that are maintained in a reservoir where they cause no harm, transmit from the reservoir to a new host. I have been studying the replication, molecular basis for pathogenesis, and host responses to emerging viruses, including influenza virus, Ebola virus, and SARS-CoV-2, and using the knowledge gained from these studies to develop antivirals and vaccines.Influenza viruses cause epidemics every winter, but occasionally new influenza viruses emerge and spread worldwide (pandemic). We established a technique that allows us to make influenza viruses artificially. This technique is now widely used for basic research and for the development of vaccines against highly pathogenic ...
      PubDate: Sun, 16 Apr 2023 01:54:08 +010
      DOI: 10.2302/kjm.abstract_72_1-2.abstractemerging infections are caused when microorganisms that are main
       
  • The Unlikely Development of CAR T Cells: a Brief History and Prospects for
           the Future

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: Keio J Med. 2023;72(1):26. doi: 10.2302/kjm.ABSTRACT_72_1-1.ABSTRACTThe quest to cure cancer has been one of the Holy Grails of medicine. The discovery I am going to share with you, CAR T cells, is a promising new form of therapy of cancer that offers the prospect of curing cancer using the immune system. CAR T cells are the first form of synthetic biology to enter the practice of medicine. The notion of using the immune system to fight cancer is an old idea. Over a century ago, bacteria were ground up and injected into patients with late-stage cancers, and occasionally the cancer would disappear. However, we now have precise tools for genetic editing and gene insertion like CRISPR/Cas9 to rewrite the DNA code, offering the possibility to improve the immune system over what has evolved in ...
      PubDate: Sun, 16 Apr 2023 01:54:08 +010
      DOI: 10.2302/kjm.abstract_72_1-1.abstractthe quest to cure cancer has been one of the holy grails of medi
       
  • Addressing the Threat of Emerging Viral Infections

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: Keio J Med. 2023;72(1):27. doi: 10.2302/kjm.ABSTRACT_72_1-2.ABSTRACTEmerging infections are caused when microorganisms that are maintained in a reservoir where they cause no harm, transmit from the reservoir to a new host. I have been studying the replication, molecular basis for pathogenesis, and host responses to emerging viruses, including influenza virus, Ebola virus, and SARS-CoV-2, and using the knowledge gained from these studies to develop antivirals and vaccines.Influenza viruses cause epidemics every winter, but occasionally new influenza viruses emerge and spread worldwide (pandemic). We established a technique that allows us to make influenza viruses artificially. This technique is now widely used for basic research and for the development of vaccines against highly pathogenic ...
      PubDate: Sun, 16 Apr 2023 01:54:08 +010
      DOI: 10.2302/kjm.abstract_72_1-2.abstractemerging infections are caused when microorganisms that are main
       
  • The Unlikely Development of CAR T Cells: a Brief History and Prospects for
           the Future

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: Keio J Med. 2023;72(1):26. doi: 10.2302/kjm.ABSTRACT_72_1-1.ABSTRACTThe quest to cure cancer has been one of the Holy Grails of medicine. The discovery I am going to share with you, CAR T cells, is a promising new form of therapy of cancer that offers the prospect of curing cancer using the immune system. CAR T cells are the first form of synthetic biology to enter the practice of medicine. The notion of using the immune system to fight cancer is an old idea. Over a century ago, bacteria were ground up and injected into patients with late-stage cancers, and occasionally the cancer would disappear. However, we now have precise tools for genetic editing and gene insertion like CRISPR/Cas9 to rewrite the DNA code, offering the possibility to improve the immune system over what has evolved in ...
      PubDate: Sun, 16 Apr 2023 01:54:08 +010
      DOI: 10.2302/kjm.abstract_72_1-1.abstractthe quest to cure cancer has been one of the holy grails of medi
       
  • Addressing the Threat of Emerging Viral Infections

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: Keio J Med. 2023;72(1):27. doi: 10.2302/kjm.ABSTRACT_72_1-2.ABSTRACTEmerging infections are caused when microorganisms that are maintained in a reservoir where they cause no harm, transmit from the reservoir to a new host. I have been studying the replication, molecular basis for pathogenesis, and host responses to emerging viruses, including influenza virus, Ebola virus, and SARS-CoV-2, and using the knowledge gained from these studies to develop antivirals and vaccines.Influenza viruses cause epidemics every winter, but occasionally new influenza viruses emerge and spread worldwide (pandemic). We established a technique that allows us to make influenza viruses artificially. This technique is now widely used for basic research and for the development of vaccines against highly pathogenic ...
      PubDate: Sun, 16 Apr 2023 01:54:08 +010
      DOI: 10.2302/kjm.abstract_72_1-2.abstractemerging infections are caused when microorganisms that are main
       
  • The Unlikely Development of CAR T Cells: a Brief History and Prospects for
           the Future

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: Keio J Med. 2023;72(1):26. doi: 10.2302/kjm.ABSTRACT_72_1-1.ABSTRACTThe quest to cure cancer has been one of the Holy Grails of medicine. The discovery I am going to share with you, CAR T cells, is a promising new form of therapy of cancer that offers the prospect of curing cancer using the immune system. CAR T cells are the first form of synthetic biology to enter the practice of medicine. The notion of using the immune system to fight cancer is an old idea. Over a century ago, bacteria were ground up and injected into patients with late-stage cancers, and occasionally the cancer would disappear. However, we now have precise tools for genetic editing and gene insertion like CRISPR/Cas9 to rewrite the DNA code, offering the possibility to improve the immune system over what has evolved in ...
      PubDate: Sun, 16 Apr 2023 01:54:08 +010
      DOI: 10.2302/kjm.abstract_72_1-1.abstractthe quest to cure cancer has been one of the holy grails of medi
       
  • Addressing the Threat of Emerging Viral Infections

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: Keio J Med. 2023;72(1):27. doi: 10.2302/kjm.ABSTRACT_72_1-2.ABSTRACTEmerging infections are caused when microorganisms that are maintained in a reservoir where they cause no harm, transmit from the reservoir to a new host. I have been studying the replication, molecular basis for pathogenesis, and host responses to emerging viruses, including influenza virus, Ebola virus, and SARS-CoV-2, and using the knowledge gained from these studies to develop antivirals and vaccines.Influenza viruses cause epidemics every winter, but occasionally new influenza viruses emerge and spread worldwide (pandemic). We established a technique that allows us to make influenza viruses artificially. This technique is now widely used for basic research and for the development of vaccines against highly pathogenic ...
      PubDate: Sun, 16 Apr 2023 01:54:08 +010
      DOI: 10.2302/kjm.abstract_72_1-2.abstractemerging infections are caused when microorganisms that are main
       
  • The Unlikely Development of CAR T Cells: a Brief History and Prospects for
           the Future

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: Keio J Med. 2023;72(1):26. doi: 10.2302/kjm.ABSTRACT_72_1-1.ABSTRACTThe quest to cure cancer has been one of the Holy Grails of medicine. The discovery I am going to share with you, CAR T cells, is a promising new form of therapy of cancer that offers the prospect of curing cancer using the immune system. CAR T cells are the first form of synthetic biology to enter the practice of medicine. The notion of using the immune system to fight cancer is an old idea. Over a century ago, bacteria were ground up and injected into patients with late-stage cancers, and occasionally the cancer would disappear. However, we now have precise tools for genetic editing and gene insertion like CRISPR/Cas9 to rewrite the DNA code, offering the possibility to improve the immune system over what has evolved in ...
      PubDate: Sun, 16 Apr 2023 01:54:08 +010
      DOI: 10.2302/kjm.abstract_72_1-1.abstractthe quest to cure cancer has been one of the holy grails of medi
       
  • Addressing the Threat of Emerging Viral Infections

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: Keio J Med. 2023;72(1):27. doi: 10.2302/kjm.ABSTRACT_72_1-2.ABSTRACTEmerging infections are caused when microorganisms that are maintained in a reservoir where they cause no harm, transmit from the reservoir to a new host. I have been studying the replication, molecular basis for pathogenesis, and host responses to emerging viruses, including influenza virus, Ebola virus, and SARS-CoV-2, and using the knowledge gained from these studies to develop antivirals and vaccines.Influenza viruses cause epidemics every winter, but occasionally new influenza viruses emerge and spread worldwide (pandemic). We established a technique that allows us to make influenza viruses artificially. This technique is now widely used for basic research and for the development of vaccines against highly pathogenic ...
      PubDate: Sun, 16 Apr 2023 01:54:08 +010
      DOI: 10.2302/kjm.abstract_72_1-2.abstractemerging infections are caused when microorganisms that are main
       
  • The Unlikely Development of CAR T Cells: a Brief History and Prospects for
           the Future

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: Keio J Med. 2023;72(1):26. doi: 10.2302/kjm.ABSTRACT_72_1-1.ABSTRACTThe quest to cure cancer has been one of the Holy Grails of medicine. The discovery I am going to share with you, CAR T cells, is a promising new form of therapy of cancer that offers the prospect of curing cancer using the immune system. CAR T cells are the first form of synthetic biology to enter the practice of medicine. The notion of using the immune system to fight cancer is an old idea. Over a century ago, bacteria were ground up and injected into patients with late-stage cancers, and occasionally the cancer would disappear. However, we now have precise tools for genetic editing and gene insertion like CRISPR/Cas9 to rewrite the DNA code, offering the possibility to improve the immune system over what has evolved in ...
      PubDate: Sun, 16 Apr 2023 01:54:08 +010
      DOI: 10.2302/kjm.abstract_72_1-1.abstractthe quest to cure cancer has been one of the holy grails of medi
       
  • Addressing the Threat of Emerging Viral Infections

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: Keio J Med. 2023;72(1):27. doi: 10.2302/kjm.ABSTRACT_72_1-2.ABSTRACTEmerging infections are caused when microorganisms that are maintained in a reservoir where they cause no harm, transmit from the reservoir to a new host. I have been studying the replication, molecular basis for pathogenesis, and host responses to emerging viruses, including influenza virus, Ebola virus, and SARS-CoV-2, and using the knowledge gained from these studies to develop antivirals and vaccines.Influenza viruses cause epidemics every winter, but occasionally new influenza viruses emerge and spread worldwide (pandemic). We established a technique that allows us to make influenza viruses artificially. This technique is now widely used for basic research and for the development of vaccines against highly pathogenic ...
      PubDate: Sun, 16 Apr 2023 01:54:08 +010
      DOI: 10.2302/kjm.abstract_72_1-2.abstractemerging infections are caused when microorganisms that are main
       
  • The Unlikely Development of CAR T Cells: a Brief History and Prospects for
           the Future

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: Keio J Med. 2023;72(1):26. doi: 10.2302/kjm.ABSTRACT_72_1-1.ABSTRACTThe quest to cure cancer has been one of the Holy Grails of medicine. The discovery I am going to share with you, CAR T cells, is a promising new form of therapy of cancer that offers the prospect of curing cancer using the immune system. CAR T cells are the first form of synthetic biology to enter the practice of medicine. The notion of using the immune system to fight cancer is an old idea. Over a century ago, bacteria were ground up and injected into patients with late-stage cancers, and occasionally the cancer would disappear. However, we now have precise tools for genetic editing and gene insertion like CRISPR/Cas9 to rewrite the DNA code, offering the possibility to improve the immune system over what has evolved in ...
      PubDate: Sun, 16 Apr 2023 01:54:08 +010
      DOI: 10.2302/kjm.abstract_72_1-1.abstractthe quest to cure cancer has been one of the holy grails of medi
       
  • Addressing the Threat of Emerging Viral Infections

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: Keio J Med. 2023;72(1):27. doi: 10.2302/kjm.ABSTRACT_72_1-2.ABSTRACTEmerging infections are caused when microorganisms that are maintained in a reservoir where they cause no harm, transmit from the reservoir to a new host. I have been studying the replication, molecular basis for pathogenesis, and host responses to emerging viruses, including influenza virus, Ebola virus, and SARS-CoV-2, and using the knowledge gained from these studies to develop antivirals and vaccines.Influenza viruses cause epidemics every winter, but occasionally new influenza viruses emerge and spread worldwide (pandemic). We established a technique that allows us to make influenza viruses artificially. This technique is now widely used for basic research and for the development of vaccines against highly pathogenic ...
      PubDate: Sun, 16 Apr 2023 01:54:08 +010
      DOI: 10.2302/kjm.abstract_72_1-2.abstractemerging infections are caused when microorganisms that are main
       
  • The Unlikely Development of CAR T Cells: a Brief History and Prospects for
           the Future

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: Keio J Med. 2023;72(1):26. doi: 10.2302/kjm.ABSTRACT_72_1-1.ABSTRACTThe quest to cure cancer has been one of the Holy Grails of medicine. The discovery I am going to share with you, CAR T cells, is a promising new form of therapy of cancer that offers the prospect of curing cancer using the immune system. CAR T cells are the first form of synthetic biology to enter the practice of medicine. The notion of using the immune system to fight cancer is an old idea. Over a century ago, bacteria were ground up and injected into patients with late-stage cancers, and occasionally the cancer would disappear. However, we now have precise tools for genetic editing and gene insertion like CRISPR/Cas9 to rewrite the DNA code, offering the possibility to improve the immune system over what has evolved in ...
      PubDate: Sun, 16 Apr 2023 01:54:08 +010
      DOI: 10.2302/kjm.abstract_72_1-1.abstractthe quest to cure cancer has been one of the holy grails of medi
       
  • Addressing the Threat of Emerging Viral Infections

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: Keio J Med. 2023;72(1):27. doi: 10.2302/kjm.ABSTRACT_72_1-2.ABSTRACTEmerging infections are caused when microorganisms that are maintained in a reservoir where they cause no harm, transmit from the reservoir to a new host. I have been studying the replication, molecular basis for pathogenesis, and host responses to emerging viruses, including influenza virus, Ebola virus, and SARS-CoV-2, and using the knowledge gained from these studies to develop antivirals and vaccines.Influenza viruses cause epidemics every winter, but occasionally new influenza viruses emerge and spread worldwide (pandemic). We established a technique that allows us to make influenza viruses artificially. This technique is now widely used for basic research and for the development of vaccines against highly pathogenic ...
      PubDate: Sun, 16 Apr 2023 01:54:08 +010
      DOI: 10.2302/kjm.abstract_72_1-2.abstractemerging infections are caused when microorganisms that are main
       
  • The Unlikely Development of CAR T Cells: a Brief History and Prospects for
           the Future

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: Keio J Med. 2023;72(1):26. doi: 10.2302/kjm.ABSTRACT_72_1-1.ABSTRACTThe quest to cure cancer has been one of the Holy Grails of medicine. The discovery I am going to share with you, CAR T cells, is a promising new form of therapy of cancer that offers the prospect of curing cancer using the immune system. CAR T cells are the first form of synthetic biology to enter the practice of medicine. The notion of using the immune system to fight cancer is an old idea. Over a century ago, bacteria were ground up and injected into patients with late-stage cancers, and occasionally the cancer would disappear. However, we now have precise tools for genetic editing and gene insertion like CRISPR/Cas9 to rewrite the DNA code, offering the possibility to improve the immune system over what has evolved in ...
      PubDate: Sun, 16 Apr 2023 01:54:08 +010
      DOI: 10.2302/kjm.abstract_72_1-1.abstractthe quest to cure cancer has been one of the holy grails of medi
       
  • Addressing the Threat of Emerging Viral Infections

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: Keio J Med. 2023;72(1):27. doi: 10.2302/kjm.ABSTRACT_72_1-2.ABSTRACTEmerging infections are caused when microorganisms that are maintained in a reservoir where they cause no harm, transmit from the reservoir to a new host. I have been studying the replication, molecular basis for pathogenesis, and host responses to emerging viruses, including influenza virus, Ebola virus, and SARS-CoV-2, and using the knowledge gained from these studies to develop antivirals and vaccines.Influenza viruses cause epidemics every winter, but occasionally new influenza viruses emerge and spread worldwide (pandemic). We established a technique that allows us to make influenza viruses artificially. This technique is now widely used for basic research and for the development of vaccines against highly pathogenic ...
      PubDate: Sun, 16 Apr 2023 01:54:08 +010
      DOI: 10.2302/kjm.abstract_72_1-2.abstractemerging infections are caused when microorganisms that are main
       
  • The Unlikely Development of CAR T Cells: a Brief History and Prospects for
           the Future

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: Keio J Med. 2023;72(1):26. doi: 10.2302/kjm.ABSTRACT_72_1-1.ABSTRACTThe quest to cure cancer has been one of the Holy Grails of medicine. The discovery I am going to share with you, CAR T cells, is a promising new form of therapy of cancer that offers the prospect of curing cancer using the immune system. CAR T cells are the first form of synthetic biology to enter the practice of medicine. The notion of using the immune system to fight cancer is an old idea. Over a century ago, bacteria were ground up and injected into patients with late-stage cancers, and occasionally the cancer would disappear. However, we now have precise tools for genetic editing and gene insertion like CRISPR/Cas9 to rewrite the DNA code, offering the possibility to improve the immune system over what has evolved in ...
      PubDate: Sun, 16 Apr 2023 01:54:08 +010
      DOI: 10.2302/kjm.abstract_72_1-1.abstractthe quest to cure cancer has been one of the holy grails of medi
       
  • Addressing the Threat of Emerging Viral Infections

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      Authors: The Keio Journal of Medicine
      Abstract: Keio J Med. 2023;72(1):27. doi: 10.2302/kjm.ABSTRACT_72_1-2.ABSTRACTEmerging infections are caused when microorganisms that are maintained in a reservoir where they cause no harm, transmit from the reservoir to a new host. I have been studying the replication, molecular basis for pathogenesis, and host responses to emerging viruses, including influenza virus, Ebola virus, and SARS-CoV-2, and using the knowledge gained from these studies to develop antivirals and vaccines.Influenza viruses cause epidemics every winter, but occasionally new influenza viruses emerge and spread worldwide (pandemic). We established a technique that allows us to make influenza viruses artificially. This technique is now widely used for basic research and for the development of vaccines against highly pathogenic ...
      PubDate: Sun, 16 Apr 2023 01:54:08 +010
      DOI: 10.2302/kjm.abstract_72_1-2.abstractemerging infections are caused when microorganisms that are main
       
  • The Unlikely Development of CAR T Cells: a Brief History and Prospects for
           the Future

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: Keio J Med. 2023;72(1):26. doi: 10.2302/kjm.ABSTRACT_72_1-1.ABSTRACTThe quest to cure cancer has been one of the Holy Grails of medicine. The discovery I am going to share with you, CAR T cells, is a promising new form of therapy of cancer that offers the prospect of curing cancer using the immune system. CAR T cells are the first form of synthetic biology to enter the practice of medicine. The notion of using the immune system to fight cancer is an old idea. Over a century ago, bacteria were ground up and injected into patients with late-stage cancers, and occasionally the cancer would disappear. However, we now have precise tools for genetic editing and gene insertion like CRISPR/Cas9 to rewrite the DNA code, offering the possibility to improve the immune system over what has evolved in ...
      PubDate: Sun, 16 Apr 2023 01:54:08 +010
      DOI: 10.2302/kjm.abstract_72_1-1.abstractthe quest to cure cancer has been one of the holy grails of medi
       
  • Addressing the Threat of Emerging Viral Infections

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: Keio J Med. 2023;72(1):27. doi: 10.2302/kjm.ABSTRACT_72_1-2.ABSTRACTEmerging infections are caused when microorganisms that are maintained in a reservoir where they cause no harm, transmit from the reservoir to a new host. I have been studying the replication, molecular basis for pathogenesis, and host responses to emerging viruses, including influenza virus, Ebola virus, and SARS-CoV-2, and using the knowledge gained from these studies to develop antivirals and vaccines.Influenza viruses cause epidemics every winter, but occasionally new influenza viruses emerge and spread worldwide (pandemic). We established a technique that allows us to make influenza viruses artificially. This technique is now widely used for basic research and for the development of vaccines against highly pathogenic ...
      PubDate: Sun, 16 Apr 2023 01:54:08 +010
      DOI: 10.2302/kjm.abstract_72_1-2.abstractemerging infections are caused when microorganisms that are main
       
  • The Unlikely Development of CAR T Cells: a Brief History and Prospects for
           the Future

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: Keio J Med. 2023;72(1):26. doi: 10.2302/kjm.ABSTRACT_72_1-1.ABSTRACTThe quest to cure cancer has been one of the Holy Grails of medicine. The discovery I am going to share with you, CAR T cells, is a promising new form of therapy of cancer that offers the prospect of curing cancer using the immune system. CAR T cells are the first form of synthetic biology to enter the practice of medicine. The notion of using the immune system to fight cancer is an old idea. Over a century ago, bacteria were ground up and injected into patients with late-stage cancers, and occasionally the cancer would disappear. However, we now have precise tools for genetic editing and gene insertion like CRISPR/Cas9 to rewrite the DNA code, offering the possibility to improve the immune system over what has evolved in ...
      PubDate: Fri, 31 Mar 2023 16:34:52 +010
      DOI: 10.2302/kjm.abstract_72_1-1.abstractthe quest to cure cancer has been one of the holy grails of medi
       
  • Addressing the Threat of Emerging Viral Infections

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: Keio J Med. 2023;72(1):27. doi: 10.2302/kjm.ABSTRACT_72_1-2.ABSTRACTEmerging infections are caused when microorganisms that are maintained in a reservoir where they cause no harm, transmit from the reservoir to a new host. I have been studying the replication, molecular basis for pathogenesis, and host responses to emerging viruses, including influenza virus, Ebola virus, and SARS-CoV-2, and using the knowledge gained from these studies to develop antivirals and vaccines.Influenza viruses cause epidemics every winter, but occasionally new influenza viruses emerge and spread worldwide (pandemic). We established a technique that allows us to make influenza viruses artificially. This technique is now widely used for basic research and for the development of vaccines against highly pathogenic ...
      PubDate: Fri, 31 Mar 2023 16:34:52 +010
      DOI: 10.2302/kjm.abstract_72_1-2.abstractemerging infections are caused when microorganisms that are main
       
  • The Unlikely Development of CAR T Cells: a Brief History and Prospects for
           the Future

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: Keio J Med. 2023;72(1):26. doi: 10.2302/kjm.ABSTRACT_72_1-1.ABSTRACTThe quest to cure cancer has been one of the Holy Grails of medicine. The discovery I am going to share with you, CAR T cells, is a promising new form of therapy of cancer that offers the prospect of curing cancer using the immune system. CAR T cells are the first form of synthetic biology to enter the practice of medicine. The notion of using the immune system to fight cancer is an old idea. Over a century ago, bacteria were ground up and injected into patients with late-stage cancers, and occasionally the cancer would disappear. However, we now have precise tools for genetic editing and gene insertion like CRISPR/Cas9 to rewrite the DNA code, offering the possibility to improve the immune system over what has evolved in ...
      PubDate: Fri, 31 Mar 2023 16:34:52 +010
      DOI: 10.2302/kjm.abstract_72_1-1.abstractthe quest to cure cancer has been one of the holy grails of medi
       
  • Addressing the Threat of Emerging Viral Infections

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: Keio J Med. 2023;72(1):27. doi: 10.2302/kjm.ABSTRACT_72_1-2.ABSTRACTEmerging infections are caused when microorganisms that are maintained in a reservoir where they cause no harm, transmit from the reservoir to a new host. I have been studying the replication, molecular basis for pathogenesis, and host responses to emerging viruses, including influenza virus, Ebola virus, and SARS-CoV-2, and using the knowledge gained from these studies to develop antivirals and vaccines.Influenza viruses cause epidemics every winter, but occasionally new influenza viruses emerge and spread worldwide (pandemic). We established a technique that allows us to make influenza viruses artificially. This technique is now widely used for basic research and for the development of vaccines against highly pathogenic ...
      PubDate: Fri, 31 Mar 2023 16:34:52 +010
      DOI: 10.2302/kjm.abstract_72_1-2.abstractemerging infections are caused when microorganisms that are main
       
  • The Unlikely Development of CAR T Cells: a Brief History and Prospects for
           the Future

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: Keio J Med. 2023;72(1):26. doi: 10.2302/kjm.ABSTRACT_72_1-1.ABSTRACTThe quest to cure cancer has been one of the Holy Grails of medicine. The discovery I am going to share with you, CAR T cells, is a promising new form of therapy of cancer that offers the prospect of curing cancer using the immune system. CAR T cells are the first form of synthetic biology to enter the practice of medicine. The notion of using the immune system to fight cancer is an old idea. Over a century ago, bacteria were ground up and injected into patients with late-stage cancers, and occasionally the cancer would disappear. However, we now have precise tools for genetic editing and gene insertion like CRISPR/Cas9 to rewrite the DNA code, offering the possibility to improve the immune system over what has evolved in ...
      PubDate: Fri, 31 Mar 2023 16:34:52 +010
      DOI: 10.2302/kjm.abstract_72_1-1.abstractthe quest to cure cancer has been one of the holy grails of medi
       
  • Addressing the Threat of Emerging Viral Infections

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: Keio J Med. 2023;72(1):27. doi: 10.2302/kjm.ABSTRACT_72_1-2.ABSTRACTEmerging infections are caused when microorganisms that are maintained in a reservoir where they cause no harm, transmit from the reservoir to a new host. I have been studying the replication, molecular basis for pathogenesis, and host responses to emerging viruses, including influenza virus, Ebola virus, and SARS-CoV-2, and using the knowledge gained from these studies to develop antivirals and vaccines.Influenza viruses cause epidemics every winter, but occasionally new influenza viruses emerge and spread worldwide (pandemic). We established a technique that allows us to make influenza viruses artificially. This technique is now widely used for basic research and for the development of vaccines against highly pathogenic ...
      PubDate: Fri, 31 Mar 2023 16:34:52 +010
      DOI: 10.2302/kjm.abstract_72_1-2.abstractemerging infections are caused when microorganisms that are main
       
  • Multiple Mutations within Individual Oncogenes: Examples and Clinical
           Implications

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      Authors: The Keio Journal of Medicine
      Abstract: Keio J Med. 2023 Mar 21. doi: 10.2302/kjm.2022-0026-OA. Online ahead of print.ABSTRACTGain-of-function mutations had been believed to function as a single mutation in oncogenes, although some secondary mutations, such as EGFR T790M mutations, are frequently acquired in patients that are resistant to tyrosine kinase inhibitor treatment. Recently, we and other investigators have reported that multiple mutations (MMs) frequently occur in the same oncogene before any therapy. In a recent pan-cancer study, we identified 14 pan-cancer oncogenes (such as PIK3CA and EGFR) and 6 cancer type-specific oncogenes that are significantly affected by MMs. Of these, 9% of cases with at least one mutation have MMs that are cis-presenting on the same allele. Interestingly, MMs show distinct mutational patter...
      PubDate: Fri, 31 Mar 2023 16:34:52 +010
      DOI: 10.2302/kjm.2022-0026-oa. online ahead of print.abstractgain-of-function mutations had been believed
       
  • Network Approaches to Uncover Pathogenesis and Therapeutic Targets of
           Inflammatory Bowel Diseases

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      Authors: The Keio Journal of Medicine
      Abstract: Keio J Med. 2023 Mar 10. doi: 10.2302/kjm.2022-0015-IR. Online ahead of print.ABSTRACTInflammatory bowel diseases (IBD) are currently recognized to involve chronic intestinal inflammation in genetically susceptible individuals. Patients with IBD mainly develop gastrointestinal inflammation, but it is sometimes accompanied by extraintestinal manifestations such as arthritis, erythema nodosum, episcleritis, pyoderma gangrenosum, uveitis, and primary sclerosing cholangitis. These clinical aspects imply the importance of interorgan networks in IBD. In the gastrointestinal tract, immune cells are influenced by multiple local environmental factors including microbiota, dietary environment, and intercellular networks, which further alter molecular networks in immune cells. Therefore, deciphering ...
      PubDate: Fri, 31 Mar 2023 16:34:52 +010
      DOI: 10.2302/kjm.2022-0015-ir. online ahead of print.abstractinflammatory bowel diseases (ibd) are curren
       
  • Pupil Dynamics-derived Sleep Stage Classification of a Head-fixed Mouse
           Using a Recurrent Neural Network

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      Authors: The Keio Journal of Medicine
      Abstract: Keio J Med. 2023 Feb 4. doi: 10.2302/kjm.2022-0020-OA. Online ahead of print.ABSTRACTThe standard method for sleep state classification is thresholding the amplitudes of electroencephalography (EEG) and electromyography (EMG) data, followed by manual correction by an expert. Although popular, this method has some shortcomings: (1) the time-consuming manual correction by human experts is sometimes a bottleneck hindering sleep studies, (2) EEG electrodes on the skull interfere with wide-field imaging of the cortical activity of a head-fixed mouse under a microscope, (3) invasive surgery to fix the electrodes on the thin mouse skull risks brain tissue injury, and (4) metal electrodes for EEG and EMG recording are difficult to apply to some experimental apparatus such as that for functional ma...
      PubDate: Fri, 31 Mar 2023 16:34:52 +010
      DOI: 10.2302/kjm.2022-0020-oa. online ahead of print.abstractthe standard method for sleep state classifi
       
  • Clinical Complete Response of Recurrent Gastric Cancer after Third-line
           CPT-11 Chemotherapy

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      Authors: The Keio Journal of Medicine
      Abstract: In conclusion, even if irAEs occur in a patient, continuing chemotherapy should be considered. However, if cCR is achieved, discontinuation of chemotherapy might be a strategic treatment option.PMID:36740273
      DOI :10.2302/kjm.2022-0004-CR (Source: The Keio Journal of Medicine)
      PubDate: Fri, 31 Mar 2023 16:34:52 +010
       
  • Pupil Dynamics-derived Sleep Stage Classification of a Head-fixed Mouse
           Using a Recurrent Neural Network

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: Keio J Med. 2023 Feb 4. doi: 10.2302/kjm.2022-0020-OA. Online ahead of print.ABSTRACTThe standard method for sleep state classification is thresholding the amplitudes of electroencephalography (EEG) and electromyography (EMG) data, followed by manual correction by an expert. Although popular, this method has some shortcomings: (1) the time-consuming manual correction by human experts is sometimes a bottleneck hindering sleep studies, (2) EEG electrodes on the skull interfere with wide-field imaging of the cortical activity of a head-fixed mouse under a microscope, (3) invasive surgery to fix the electrodes on the thin mouse skull risks brain tissue injury, and (4) metal electrodes for EEG and EMG recording are difficult to apply to some experimental apparatus such as that for functional ma...
      PubDate: Fri, 31 Mar 2023 16:34:52 +010
      DOI: 10.2302/kjm.2022-0020-oa. online ahead of print.abstractthe standard method for sleep state classifi
       
  • Clinical Complete Response of Recurrent Gastric Cancer after Third-line
           CPT-11 Chemotherapy

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: In conclusion, even if irAEs occur in a patient, continuing chemotherapy should be considered. However, if cCR is achieved, discontinuation of chemotherapy might be a strategic treatment option.PMID:36740273
      DOI :10.2302/kjm.2022-0004-CR (Source: The Keio Journal of Medicine)
      PubDate: Fri, 31 Mar 2023 16:34:52 +010
       
  • Pupil Dynamics-derived Sleep Stage Classification of a Head-fixed Mouse
           Using a Recurrent Neural Network

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: Keio J Med. 2023 Feb 4. doi: 10.2302/kjm.2022-0020-OA. Online ahead of print.ABSTRACTThe standard method for sleep state classification is thresholding the amplitudes of electroencephalography (EEG) and electromyography (EMG) data, followed by manual correction by an expert. Although popular, this method has some shortcomings: (1) the time-consuming manual correction by human experts is sometimes a bottleneck hindering sleep studies, (2) EEG electrodes on the skull interfere with wide-field imaging of the cortical activity of a head-fixed mouse under a microscope, (3) invasive surgery to fix the electrodes on the thin mouse skull risks brain tissue injury, and (4) metal electrodes for EEG and EMG recording are difficult to apply to some experimental apparatus such as that for functional ma...
      PubDate: Fri, 31 Mar 2023 16:34:52 +010
      DOI: 10.2302/kjm.2022-0020-oa. online ahead of print.abstractthe standard method for sleep state classifi
       
  • Clinical Complete Response of Recurrent Gastric Cancer after Third-line
           CPT-11 Chemotherapy

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: In conclusion, even if irAEs occur in a patient, continuing chemotherapy should be considered. However, if cCR is achieved, discontinuation of chemotherapy might be a strategic treatment option.PMID:36740273
      DOI :10.2302/kjm.2022-0004-CR (Source: The Keio Journal of Medicine)
      PubDate: Fri, 31 Mar 2023 16:34:52 +010
       
  • Pupil Dynamics-derived Sleep Stage Classification of a Head-fixed Mouse
           Using a Recurrent Neural Network

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: Keio J Med. 2023 Feb 4. doi: 10.2302/kjm.2022-0020-OA. Online ahead of print.ABSTRACTThe standard method for sleep state classification is thresholding the amplitudes of electroencephalography (EEG) and electromyography (EMG) data, followed by manual correction by an expert. Although popular, this method has some shortcomings: (1) the time-consuming manual correction by human experts is sometimes a bottleneck hindering sleep studies, (2) EEG electrodes on the skull interfere with wide-field imaging of the cortical activity of a head-fixed mouse under a microscope, (3) invasive surgery to fix the electrodes on the thin mouse skull risks brain tissue injury, and (4) metal electrodes for EEG and EMG recording are difficult to apply to some experimental apparatus such as that for functional ma...
      PubDate: Fri, 31 Mar 2023 16:34:52 +010
      DOI: 10.2302/kjm.2022-0020-oa. online ahead of print.abstractthe standard method for sleep state classifi
       
  • Clinical Complete Response of Recurrent Gastric Cancer after Third-line
           CPT-11 Chemotherapy

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: In conclusion, even if irAEs occur in a patient, continuing chemotherapy should be considered. However, if cCR is achieved, discontinuation of chemotherapy might be a strategic treatment option.PMID:36740273
      DOI :10.2302/kjm.2022-0004-CR (Source: The Keio Journal of Medicine)
      PubDate: Fri, 31 Mar 2023 16:34:52 +010
       
  • Pupil Dynamics-derived Sleep Stage Classification of a Head-fixed Mouse
           Using a Recurrent Neural Network

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: Keio J Med. 2023 Feb 4. doi: 10.2302/kjm.2022-0020-OA. Online ahead of print.ABSTRACTThe standard method for sleep state classification is thresholding the amplitudes of electroencephalography (EEG) and electromyography (EMG) data, followed by manual correction by an expert. Although popular, this method has some shortcomings: (1) the time-consuming manual correction by human experts is sometimes a bottleneck hindering sleep studies, (2) EEG electrodes on the skull interfere with wide-field imaging of the cortical activity of a head-fixed mouse under a microscope, (3) invasive surgery to fix the electrodes on the thin mouse skull risks brain tissue injury, and (4) metal electrodes for EEG and EMG recording are difficult to apply to some experimental apparatus such as that for functional ma...
      PubDate: Fri, 31 Mar 2023 16:34:52 +010
      DOI: 10.2302/kjm.2022-0020-oa. online ahead of print.abstractthe standard method for sleep state classifi
       
  • Clinical Complete Response of Recurrent Gastric Cancer after Third-line
           CPT-11 Chemotherapy

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: In conclusion, even if irAEs occur in a patient, continuing chemotherapy should be considered. However, if cCR is achieved, discontinuation of chemotherapy might be a strategic treatment option.PMID:36740273
      DOI :10.2302/kjm.2022-0004-CR (Source: The Keio Journal of Medicine)
      PubDate: Fri, 31 Mar 2023 16:34:52 +010
       
  • Pupil Dynamics-derived Sleep Stage Classification of a Head-fixed Mouse
           Using a Recurrent Neural Network

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: Keio J Med. 2023 Feb 4. doi: 10.2302/kjm.2022-0020-OA. Online ahead of print.ABSTRACTThe standard method for sleep state classification is thresholding the amplitudes of electroencephalography (EEG) and electromyography (EMG) data, followed by manual correction by an expert. Although popular, this method has some shortcomings: (1) the time-consuming manual correction by human experts is sometimes a bottleneck hindering sleep studies, (2) EEG electrodes on the skull interfere with wide-field imaging of the cortical activity of a head-fixed mouse under a microscope, (3) invasive surgery to fix the electrodes on the thin mouse skull risks brain tissue injury, and (4) metal electrodes for EEG and EMG recording are difficult to apply to some experimental apparatus such as that for functional ma...
      PubDate: Fri, 31 Mar 2023 16:34:52 +010
      DOI: 10.2302/kjm.2022-0020-oa. online ahead of print.abstractthe standard method for sleep state classifi
       
  • Clinical Complete Response of Recurrent Gastric Cancer after Third-line
           CPT-11 Chemotherapy

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: In conclusion, even if irAEs occur in a patient, continuing chemotherapy should be considered. However, if cCR is achieved, discontinuation of chemotherapy might be a strategic treatment option.PMID:36740273
      DOI :10.2302/kjm.2022-0004-CR (Source: The Keio Journal of Medicine)
      PubDate: Fri, 31 Mar 2023 16:34:52 +010
       
  • Pupil Dynamics-derived Sleep Stage Classification of a Head-fixed Mouse
           Using a Recurrent Neural Network

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: Keio J Med. 2023 Feb 4. doi: 10.2302/kjm.2022-0020-OA. Online ahead of print.ABSTRACTThe standard method for sleep state classification is thresholding the amplitudes of electroencephalography (EEG) and electromyography (EMG) data, followed by manual correction by an expert. Although popular, this method has some shortcomings: (1) the time-consuming manual correction by human experts is sometimes a bottleneck hindering sleep studies, (2) EEG electrodes on the skull interfere with wide-field imaging of the cortical activity of a head-fixed mouse under a microscope, (3) invasive surgery to fix the electrodes on the thin mouse skull risks brain tissue injury, and (4) metal electrodes for EEG and EMG recording are difficult to apply to some experimental apparatus such as that for functional ma...
      PubDate: Fri, 31 Mar 2023 16:34:52 +010
      DOI: 10.2302/kjm.2022-0020-oa. online ahead of print.abstractthe standard method for sleep state classifi
       
  • Clinical Complete Response of Recurrent Gastric Cancer after Third-line
           CPT-11 Chemotherapy

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: In conclusion, even if irAEs occur in a patient, continuing chemotherapy should be considered. However, if cCR is achieved, discontinuation of chemotherapy might be a strategic treatment option.PMID:36740273
      DOI :10.2302/kjm.2022-0004-CR (Source: The Keio Journal of Medicine)
      PubDate: Fri, 31 Mar 2023 16:34:52 +010
       
  • Pupil Dynamics-derived Sleep Stage Classification of a Head-fixed Mouse
           Using a Recurrent Neural Network

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: Keio J Med. 2023 Feb 4. doi: 10.2302/kjm.2022-0020-OA. Online ahead of print.ABSTRACTThe standard method for sleep state classification is thresholding the amplitudes of electroencephalography (EEG) and electromyography (EMG) data, followed by manual correction by an expert. Although popular, this method has some shortcomings: (1) the time-consuming manual correction by human experts is sometimes a bottleneck hindering sleep studies, (2) EEG electrodes on the skull interfere with wide-field imaging of the cortical activity of a head-fixed mouse under a microscope, (3) invasive surgery to fix the electrodes on the thin mouse skull risks brain tissue injury, and (4) metal electrodes for EEG and EMG recording are difficult to apply to some experimental apparatus such as that for functional ma...
      PubDate: Fri, 31 Mar 2023 16:34:52 +010
      DOI: 10.2302/kjm.2022-0020-oa. online ahead of print.abstractthe standard method for sleep state classifi
       
  • Clinical Complete Response of Recurrent Gastric Cancer after Third-line
           CPT-11 Chemotherapy

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: In conclusion, even if irAEs occur in a patient, continuing chemotherapy should be considered. However, if cCR is achieved, discontinuation of chemotherapy might be a strategic treatment option.PMID:36740273
      DOI :10.2302/kjm.2022-0004-CR (Source: The Keio Journal of Medicine)
      PubDate: Fri, 31 Mar 2023 16:34:52 +010
       
  • Pupil Dynamics-derived Sleep Stage Classification of a Head-fixed Mouse
           Using a Recurrent Neural Network

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: Keio J Med. 2023 Feb 4. doi: 10.2302/kjm.2022-0020-OA. Online ahead of print.ABSTRACTThe standard method for sleep state classification is thresholding the amplitudes of electroencephalography (EEG) and electromyography (EMG) data, followed by manual correction by an expert. Although popular, this method has some shortcomings: (1) the time-consuming manual correction by human experts is sometimes a bottleneck hindering sleep studies, (2) EEG electrodes on the skull interfere with wide-field imaging of the cortical activity of a head-fixed mouse under a microscope, (3) invasive surgery to fix the electrodes on the thin mouse skull risks brain tissue injury, and (4) metal electrodes for EEG and EMG recording are difficult to apply to some experimental apparatus such as that for functional ma...
      PubDate: Fri, 31 Mar 2023 16:34:52 +010
      DOI: 10.2302/kjm.2022-0020-oa. online ahead of print.abstractthe standard method for sleep state classifi
       
  • Clinical Complete Response of Recurrent Gastric Cancer after Third-line
           CPT-11 Chemotherapy

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: In conclusion, even if irAEs occur in a patient, continuing chemotherapy should be considered. However, if cCR is achieved, discontinuation of chemotherapy might be a strategic treatment option.PMID:36740273
      DOI :10.2302/kjm.2022-0004-CR (Source: The Keio Journal of Medicine)
      PubDate: Fri, 31 Mar 2023 16:34:52 +010
       
  • Pupil Dynamics-derived Sleep Stage Classification of a Head-fixed Mouse
           Using a Recurrent Neural Network

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: Keio J Med. 2023 Feb 4. doi: 10.2302/kjm.2022-0020-OA. Online ahead of print.ABSTRACTThe standard method for sleep state classification is thresholding the amplitudes of electroencephalography (EEG) and electromyography (EMG) data, followed by manual correction by an expert. Although popular, this method has some shortcomings: (1) the time-consuming manual correction by human experts is sometimes a bottleneck hindering sleep studies, (2) EEG electrodes on the skull interfere with wide-field imaging of the cortical activity of a head-fixed mouse under a microscope, (3) invasive surgery to fix the electrodes on the thin mouse skull risks brain tissue injury, and (4) metal electrodes for EEG and EMG recording are difficult to apply to some experimental apparatus such as that for functional ma...
      PubDate: Fri, 31 Mar 2023 16:34:52 +010
      DOI: 10.2302/kjm.2022-0020-oa. online ahead of print.abstractthe standard method for sleep state classifi
       
  • Clinical Complete Response of Recurrent Gastric Cancer after Third-line
           CPT-11 Chemotherapy

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: In conclusion, even if irAEs occur in a patient, continuing chemotherapy should be considered. However, if cCR is achieved, discontinuation of chemotherapy might be a strategic treatment option.PMID:36740273
      DOI :10.2302/kjm.2022-0004-CR (Source: The Keio Journal of Medicine)
      PubDate: Fri, 31 Mar 2023 16:34:52 +010
       
  • Pupil Dynamics-derived Sleep Stage Classification of a Head-fixed Mouse
           Using a Recurrent Neural Network

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: Keio J Med. 2023 Feb 4. doi: 10.2302/kjm.2022-0020-OA. Online ahead of print.ABSTRACTThe standard method for sleep state classification is thresholding the amplitudes of electroencephalography (EEG) and electromyography (EMG) data, followed by manual correction by an expert. Although popular, this method has some shortcomings: (1) the time-consuming manual correction by human experts is sometimes a bottleneck hindering sleep studies, (2) EEG electrodes on the skull interfere with wide-field imaging of the cortical activity of a head-fixed mouse under a microscope, (3) invasive surgery to fix the electrodes on the thin mouse skull risks brain tissue injury, and (4) metal electrodes for EEG and EMG recording are difficult to apply to some experimental apparatus such as that for functional ma...
      PubDate: Fri, 31 Mar 2023 16:34:52 +010
      DOI: 10.2302/kjm.2022-0020-oa. online ahead of print.abstractthe standard method for sleep state classifi
       
  • Clinical Complete Response of Recurrent Gastric Cancer after Third-line
           CPT-11 Chemotherapy

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: In conclusion, even if irAEs occur in a patient, continuing chemotherapy should be considered. However, if cCR is achieved, discontinuation of chemotherapy might be a strategic treatment option.PMID:36740273
      DOI :10.2302/kjm.2022-0004-CR (Source: The Keio Journal of Medicine)
      PubDate: Fri, 31 Mar 2023 16:34:52 +010
       
  • Pupil Dynamics-derived Sleep Stage Classification of a Head-fixed Mouse
           Using a Recurrent Neural Network

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: Keio J Med. 2023 Feb 4. doi: 10.2302/kjm.2022-0020-OA. Online ahead of print.ABSTRACTThe standard method for sleep state classification is thresholding the amplitudes of electroencephalography (EEG) and electromyography (EMG) data, followed by manual correction by an expert. Although popular, this method has some shortcomings: (1) the time-consuming manual correction by human experts is sometimes a bottleneck hindering sleep studies, (2) EEG electrodes on the skull interfere with wide-field imaging of the cortical activity of a head-fixed mouse under a microscope, (3) invasive surgery to fix the electrodes on the thin mouse skull risks brain tissue injury, and (4) metal electrodes for EEG and EMG recording are difficult to apply to some experimental apparatus such as that for functional ma...
      PubDate: Fri, 31 Mar 2023 16:34:52 +010
      DOI: 10.2302/kjm.2022-0020-oa. online ahead of print.abstractthe standard method for sleep state classifi
       
  • Clinical Complete Response of Recurrent Gastric Cancer after Third-line
           CPT-11 Chemotherapy

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: In conclusion, even if irAEs occur in a patient, continuing chemotherapy should be considered. However, if cCR is achieved, discontinuation of chemotherapy might be a strategic treatment option.PMID:36740273
      DOI :10.2302/kjm.2022-0004-CR (Source: The Keio Journal of Medicine)
      PubDate: Fri, 31 Mar 2023 16:34:52 +010
       
  • Pupil Dynamics-derived Sleep Stage Classification of a Head-fixed Mouse
           Using a Recurrent Neural Network

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: Keio J Med. 2023 Feb 4. doi: 10.2302/kjm.2022-0020-OA. Online ahead of print.ABSTRACTThe standard method for sleep state classification is thresholding the amplitudes of electroencephalography (EEG) and electromyography (EMG) data, followed by manual correction by an expert. Although popular, this method has some shortcomings: (1) the time-consuming manual correction by human experts is sometimes a bottleneck hindering sleep studies, (2) EEG electrodes on the skull interfere with wide-field imaging of the cortical activity of a head-fixed mouse under a microscope, (3) invasive surgery to fix the electrodes on the thin mouse skull risks brain tissue injury, and (4) metal electrodes for EEG and EMG recording are difficult to apply to some experimental apparatus such as that for functional ma...
      PubDate: Fri, 31 Mar 2023 16:34:52 +010
      DOI: 10.2302/kjm.2022-0020-oa. online ahead of print.abstractthe standard method for sleep state classifi
       
  • Clinical Complete Response of Recurrent Gastric Cancer after Third-line
           CPT-11 Chemotherapy

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: In conclusion, even if irAEs occur in a patient, continuing chemotherapy should be considered. However, if cCR is achieved, discontinuation of chemotherapy might be a strategic treatment option.PMID:36740273
      DOI :10.2302/kjm.2022-0004-CR (Source: The Keio Journal of Medicine)
      PubDate: Fri, 31 Mar 2023 16:34:52 +010
       
  • Pupil Dynamics-derived Sleep Stage Classification of a Head-fixed Mouse
           Using a Recurrent Neural Network

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: Keio J Med. 2023 Feb 4. doi: 10.2302/kjm.2022-0020-OA. Online ahead of print.ABSTRACTThe standard method for sleep state classification is thresholding the amplitudes of electroencephalography (EEG) and electromyography (EMG) data, followed by manual correction by an expert. Although popular, this method has some shortcomings: (1) the time-consuming manual correction by human experts is sometimes a bottleneck hindering sleep studies, (2) EEG electrodes on the skull interfere with wide-field imaging of the cortical activity of a head-fixed mouse under a microscope, (3) invasive surgery to fix the electrodes on the thin mouse skull risks brain tissue injury, and (4) metal electrodes for EEG and EMG recording are difficult to apply to some experimental apparatus such as that for functional ma...
      PubDate: Fri, 31 Mar 2023 16:34:52 +010
      DOI: 10.2302/kjm.2022-0020-oa. online ahead of print.abstractthe standard method for sleep state classifi
       
  • Clinical Complete Response of Recurrent Gastric Cancer after Third-line
           CPT-11 Chemotherapy

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: In conclusion, even if irAEs occur in a patient, continuing chemotherapy should be considered. However, if cCR is achieved, discontinuation of chemotherapy might be a strategic treatment option.PMID:36740273
      DOI :10.2302/kjm.2022-0004-CR (Source: The Keio Journal of Medicine)
      PubDate: Fri, 31 Mar 2023 16:34:52 +010
       
  • Pupil Dynamics-derived Sleep Stage Classification of a Head-fixed Mouse
           Using a Recurrent Neural Network

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: Keio J Med. 2023 Feb 4. doi: 10.2302/kjm.2022-0020-OA. Online ahead of print.ABSTRACTThe standard method for sleep state classification is thresholding the amplitudes of electroencephalography (EEG) and electromyography (EMG) data, followed by manual correction by an expert. Although popular, this method has some shortcomings: (1) the time-consuming manual correction by human experts is sometimes a bottleneck hindering sleep studies, (2) EEG electrodes on the skull interfere with wide-field imaging of the cortical activity of a head-fixed mouse under a microscope, (3) invasive surgery to fix the electrodes on the thin mouse skull risks brain tissue injury, and (4) metal electrodes for EEG and EMG recording are difficult to apply to some experimental apparatus such as that for functional ma...
      PubDate: Fri, 31 Mar 2023 16:34:52 +010
      DOI: 10.2302/kjm.2022-0020-oa. online ahead of print.abstractthe standard method for sleep state classifi
       
  • Clinical Complete Response of Recurrent Gastric Cancer after Third-line
           CPT-11 Chemotherapy

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: In conclusion, even if irAEs occur in a patient, continuing chemotherapy should be considered. However, if cCR is achieved, discontinuation of chemotherapy might be a strategic treatment option.PMID:36740273
      DOI :10.2302/kjm.2022-0004-CR (Source: The Keio Journal of Medicine)
      PubDate: Fri, 31 Mar 2023 16:34:52 +010
       
  • Pupil Dynamics-derived Sleep Stage Classification of a Head-fixed Mouse
           Using a Recurrent Neural Network

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: Keio J Med. 2023 Feb 4. doi: 10.2302/kjm.2022-0020-OA. Online ahead of print.ABSTRACTThe standard method for sleep state classification is thresholding the amplitudes of electroencephalography (EEG) and electromyography (EMG) data, followed by manual correction by an expert. Although popular, this method has some shortcomings: (1) the time-consuming manual correction by human experts is sometimes a bottleneck hindering sleep studies, (2) EEG electrodes on the skull interfere with wide-field imaging of the cortical activity of a head-fixed mouse under a microscope, (3) invasive surgery to fix the electrodes on the thin mouse skull risks brain tissue injury, and (4) metal electrodes for EEG and EMG recording are difficult to apply to some experimental apparatus such as that for functional ma...
      PubDate: Fri, 31 Mar 2023 16:34:52 +010
      DOI: 10.2302/kjm.2022-0020-oa. online ahead of print.abstractthe standard method for sleep state classifi
       
  • Clinical Complete Response of Recurrent Gastric Cancer after Third-line
           CPT-11 Chemotherapy

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: In conclusion, even if irAEs occur in a patient, continuing chemotherapy should be considered. However, if cCR is achieved, discontinuation of chemotherapy might be a strategic treatment option.PMID:36740273
      DOI :10.2302/kjm.2022-0004-CR (Source: The Keio Journal of Medicine)
      PubDate: Fri, 31 Mar 2023 16:34:52 +010
       
  • Pupil Dynamics-derived Sleep Stage Classification of a Head-fixed Mouse
           Using a Recurrent Neural Network

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: Keio J Med. 2023 Feb 4. doi: 10.2302/kjm.2022-0020-OA. Online ahead of print.ABSTRACTThe standard method for sleep state classification is thresholding the amplitudes of electroencephalography (EEG) and electromyography (EMG) data, followed by manual correction by an expert. Although popular, this method has some shortcomings: (1) the time-consuming manual correction by human experts is sometimes a bottleneck hindering sleep studies, (2) EEG electrodes on the skull interfere with wide-field imaging of the cortical activity of a head-fixed mouse under a microscope, (3) invasive surgery to fix the electrodes on the thin mouse skull risks brain tissue injury, and (4) metal electrodes for EEG and EMG recording are difficult to apply to some experimental apparatus such as that for functional ma...
      PubDate: Fri, 31 Mar 2023 16:34:52 +010
      DOI: 10.2302/kjm.2022-0020-oa. online ahead of print.abstractthe standard method for sleep state classifi
       
  • Clinical Complete Response of Recurrent Gastric Cancer after Third-line
           CPT-11 Chemotherapy

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: In conclusion, even if irAEs occur in a patient, continuing chemotherapy should be considered. However, if cCR is achieved, discontinuation of chemotherapy might be a strategic treatment option.PMID:36740273
      DOI :10.2302/kjm.2022-0004-CR (Source: The Keio Journal of Medicine)
      PubDate: Fri, 31 Mar 2023 16:34:52 +010
       
  • Pupil Dynamics-derived Sleep Stage Classification of a Head-fixed Mouse
           Using a Recurrent Neural Network

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: Keio J Med. 2023 Feb 4. doi: 10.2302/kjm.2022-0020-OA. Online ahead of print.ABSTRACTThe standard method for sleep state classification is thresholding the amplitudes of electroencephalography (EEG) and electromyography (EMG) data, followed by manual correction by an expert. Although popular, this method has some shortcomings: (1) the time-consuming manual correction by human experts is sometimes a bottleneck hindering sleep studies, (2) EEG electrodes on the skull interfere with wide-field imaging of the cortical activity of a head-fixed mouse under a microscope, (3) invasive surgery to fix the electrodes on the thin mouse skull risks brain tissue injury, and (4) metal electrodes for EEG and EMG recording are difficult to apply to some experimental apparatus such as that for functional ma...
      PubDate: Fri, 31 Mar 2023 16:34:52 +010
      DOI: 10.2302/kjm.2022-0020-oa. online ahead of print.abstractthe standard method for sleep state classifi
       
  • Clinical Complete Response of Recurrent Gastric Cancer after Third-line
           CPT-11 Chemotherapy

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: In conclusion, even if irAEs occur in a patient, continuing chemotherapy should be considered. However, if cCR is achieved, discontinuation of chemotherapy might be a strategic treatment option.PMID:36740273
      DOI :10.2302/kjm.2022-0004-CR (Source: The Keio Journal of Medicine)
      PubDate: Fri, 31 Mar 2023 16:34:52 +010
       
  • Pupil Dynamics-derived Sleep Stage Classification of a Head-fixed Mouse
           Using a Recurrent Neural Network

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: Keio J Med. 2023 Feb 4. doi: 10.2302/kjm.2022-0020-OA. Online ahead of print.ABSTRACTThe standard method for sleep state classification is thresholding the amplitudes of electroencephalography (EEG) and electromyography (EMG) data, followed by manual correction by an expert. Although popular, this method has some shortcomings: (1) the time-consuming manual correction by human experts is sometimes a bottleneck hindering sleep studies, (2) EEG electrodes on the skull interfere with wide-field imaging of the cortical activity of a head-fixed mouse under a microscope, (3) invasive surgery to fix the electrodes on the thin mouse skull risks brain tissue injury, and (4) metal electrodes for EEG and EMG recording are difficult to apply to some experimental apparatus such as that for functional ma...
      PubDate: Fri, 31 Mar 2023 16:34:52 +010
      DOI: 10.2302/kjm.2022-0020-oa. online ahead of print.abstractthe standard method for sleep state classifi
       
  • Clinical Complete Response of Recurrent Gastric Cancer after Third-line
           CPT-11 Chemotherapy

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: In conclusion, even if irAEs occur in a patient, continuing chemotherapy should be considered. However, if cCR is achieved, discontinuation of chemotherapy might be a strategic treatment option.PMID:36740273
      DOI :10.2302/kjm.2022-0004-CR (Source: The Keio Journal of Medicine)
      PubDate: Fri, 31 Mar 2023 16:34:52 +010
       
  • Pupil Dynamics-derived Sleep Stage Classification of a Head-fixed Mouse
           Using a Recurrent Neural Network

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: Keio J Med. 2023 Feb 4. doi: 10.2302/kjm.2022-0020-OA. Online ahead of print.ABSTRACTThe standard method for sleep state classification is thresholding the amplitudes of electroencephalography (EEG) and electromyography (EMG) data, followed by manual correction by an expert. Although popular, this method has some shortcomings: (1) the time-consuming manual correction by human experts is sometimes a bottleneck hindering sleep studies, (2) EEG electrodes on the skull interfere with wide-field imaging of the cortical activity of a head-fixed mouse under a microscope, (3) invasive surgery to fix the electrodes on the thin mouse skull risks brain tissue injury, and (4) metal electrodes for EEG and EMG recording are difficult to apply to some experimental apparatus such as that for functional ma...
      PubDate: Fri, 31 Mar 2023 16:34:52 +010
      DOI: 10.2302/kjm.2022-0020-oa. online ahead of print.abstractthe standard method for sleep state classifi
       
  • Clinical Complete Response of Recurrent Gastric Cancer after Third-line
           CPT-11 Chemotherapy

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: In conclusion, even if irAEs occur in a patient, continuing chemotherapy should be considered. However, if cCR is achieved, discontinuation of chemotherapy might be a strategic treatment option.PMID:36740273
      DOI :10.2302/kjm.2022-0004-CR (Source: The Keio Journal of Medicine)
      PubDate: Fri, 31 Mar 2023 16:34:52 +010
       
  • Pupil Dynamics-derived Sleep Stage Classification of a Head-fixed Mouse
           Using a Recurrent Neural Network

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: Keio J Med. 2023 Feb 4. doi: 10.2302/kjm.2022-0020-OA. Online ahead of print.ABSTRACTThe standard method for sleep state classification is thresholding the amplitudes of electroencephalography (EEG) and electromyography (EMG) data, followed by manual correction by an expert. Although popular, this method has some shortcomings: (1) the time-consuming manual correction by human experts is sometimes a bottleneck hindering sleep studies, (2) EEG electrodes on the skull interfere with wide-field imaging of the cortical activity of a head-fixed mouse under a microscope, (3) invasive surgery to fix the electrodes on the thin mouse skull risks brain tissue injury, and (4) metal electrodes for EEG and EMG recording are difficult to apply to some experimental apparatus such as that for functional ma...
      PubDate: Fri, 31 Mar 2023 16:34:52 +010
      DOI: 10.2302/kjm.2022-0020-oa. online ahead of print.abstractthe standard method for sleep state classifi
       
  • Clinical Complete Response of Recurrent Gastric Cancer after Third-line
           CPT-11 Chemotherapy

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: In conclusion, even if irAEs occur in a patient, continuing chemotherapy should be considered. However, if cCR is achieved, discontinuation of chemotherapy might be a strategic treatment option.PMID:36740273
      DOI :10.2302/kjm.2022-0004-CR (Source: The Keio Journal of Medicine)
      PubDate: Fri, 31 Mar 2023 16:34:52 +010
       
  • Pupil Dynamics-derived Sleep Stage Classification of a Head-fixed Mouse
           Using a Recurrent Neural Network

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: Keio J Med. 2023 Feb 4. doi: 10.2302/kjm.2022-0020-OA. Online ahead of print.ABSTRACTThe standard method for sleep state classification is thresholding the amplitudes of electroencephalography (EEG) and electromyography (EMG) data, followed by manual correction by an expert. Although popular, this method has some shortcomings: (1) the time-consuming manual correction by human experts is sometimes a bottleneck hindering sleep studies, (2) EEG electrodes on the skull interfere with wide-field imaging of the cortical activity of a head-fixed mouse under a microscope, (3) invasive surgery to fix the electrodes on the thin mouse skull risks brain tissue injury, and (4) metal electrodes for EEG and EMG recording are difficult to apply to some experimental apparatus such as that for functional ma...
      PubDate: Fri, 31 Mar 2023 16:34:52 +010
      DOI: 10.2302/kjm.2022-0020-oa. online ahead of print.abstractthe standard method for sleep state classifi
       
  • Clinical Complete Response of Recurrent Gastric Cancer after Third-line
           CPT-11 Chemotherapy

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: In conclusion, even if irAEs occur in a patient, continuing chemotherapy should be considered. However, if cCR is achieved, discontinuation of chemotherapy might be a strategic treatment option.PMID:36740273
      DOI :10.2302/kjm.2022-0004-CR (Source: The Keio Journal of Medicine)
      PubDate: Fri, 31 Mar 2023 16:34:52 +010
       
  • Pupil Dynamics-derived Sleep Stage Classification of a Head-fixed Mouse
           Using a Recurrent Neural Network

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: Keio J Med. 2023 Feb 4. doi: 10.2302/kjm.2022-0020-OA. Online ahead of print.ABSTRACTThe standard method for sleep state classification is thresholding the amplitudes of electroencephalography (EEG) and electromyography (EMG) data, followed by manual correction by an expert. Although popular, this method has some shortcomings: (1) the time-consuming manual correction by human experts is sometimes a bottleneck hindering sleep studies, (2) EEG electrodes on the skull interfere with wide-field imaging of the cortical activity of a head-fixed mouse under a microscope, (3) invasive surgery to fix the electrodes on the thin mouse skull risks brain tissue injury, and (4) metal electrodes for EEG and EMG recording are difficult to apply to some experimental apparatus such as that for functional ma...
      PubDate: Fri, 31 Mar 2023 16:34:52 +010
      DOI: 10.2302/kjm.2022-0020-oa. online ahead of print.abstractthe standard method for sleep state classifi
       
  • Clinical Complete Response of Recurrent Gastric Cancer after Third-line
           CPT-11 Chemotherapy

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: In conclusion, even if irAEs occur in a patient, continuing chemotherapy should be considered. However, if cCR is achieved, discontinuation of chemotherapy might be a strategic treatment option.PMID:36740273
      DOI :10.2302/kjm.2022-0004-CR (Source: The Keio Journal of Medicine)
      PubDate: Fri, 31 Mar 2023 16:34:52 +010
       
  • Pupil Dynamics-derived Sleep Stage Classification of a Head-fixed Mouse
           Using a Recurrent Neural Network

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: Keio J Med. 2023 Feb 4. doi: 10.2302/kjm.2022-0020-OA. Online ahead of print.ABSTRACTThe standard method for sleep state classification is thresholding the amplitudes of electroencephalography (EEG) and electromyography (EMG) data, followed by manual correction by an expert. Although popular, this method has some shortcomings: (1) the time-consuming manual correction by human experts is sometimes a bottleneck hindering sleep studies, (2) EEG electrodes on the skull interfere with wide-field imaging of the cortical activity of a head-fixed mouse under a microscope, (3) invasive surgery to fix the electrodes on the thin mouse skull risks brain tissue injury, and (4) metal electrodes for EEG and EMG recording are difficult to apply to some experimental apparatus such as that for functional ma...
      PubDate: Fri, 31 Mar 2023 16:34:52 +010
      DOI: 10.2302/kjm.2022-0020-oa. online ahead of print.abstractthe standard method for sleep state classifi
       
  • Clinical Complete Response of Recurrent Gastric Cancer after Third-line
           CPT-11 Chemotherapy

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: In conclusion, even if irAEs occur in a patient, continuing chemotherapy should be considered. However, if cCR is achieved, discontinuation of chemotherapy might be a strategic treatment option.PMID:36740273
      DOI :10.2302/kjm.2022-0004-CR (Source: The Keio Journal of Medicine)
      PubDate: Fri, 31 Mar 2023 16:34:52 +010
       
  • Pupil Dynamics-derived Sleep Stage Classification of a Head-fixed Mouse
           Using a Recurrent Neural Network

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: Keio J Med. 2023 Feb 4. doi: 10.2302/kjm.2022-0020-OA. Online ahead of print.ABSTRACTThe standard method for sleep state classification is thresholding the amplitudes of electroencephalography (EEG) and electromyography (EMG) data, followed by manual correction by an expert. Although popular, this method has some shortcomings: (1) the time-consuming manual correction by human experts is sometimes a bottleneck hindering sleep studies, (2) EEG electrodes on the skull interfere with wide-field imaging of the cortical activity of a head-fixed mouse under a microscope, (3) invasive surgery to fix the electrodes on the thin mouse skull risks brain tissue injury, and (4) metal electrodes for EEG and EMG recording are difficult to apply to some experimental apparatus such as that for functional ma...
      PubDate: Fri, 31 Mar 2023 16:34:52 +010
      DOI: 10.2302/kjm.2022-0020-oa. online ahead of print.abstractthe standard method for sleep state classifi
       
  • Clinical Complete Response of Recurrent Gastric Cancer after Third-line
           CPT-11 Chemotherapy

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: In conclusion, even if irAEs occur in a patient, continuing chemotherapy should be considered. However, if cCR is achieved, discontinuation of chemotherapy might be a strategic treatment option.PMID:36740273
      DOI :10.2302/kjm.2022-0004-CR (Source: The Keio Journal of Medicine)
      PubDate: Fri, 31 Mar 2023 16:34:52 +010
       
  • Reoperative Aortic Valve Replacement for Structural Valve Deterioration
           through a Lower Hemisternotomy after a Previous Bentall Procedure in a
           Patient with Tracheostomy

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: This report describes a reoperative aortic valve replacement (re-AVR) for structural valve deterioration (SVD) through a lower hemisternotomy. This procedure was performed on a 71-year-old man with a tracheostomy who had previously undergone a Bentall procedure with a bioprosthetic valve to replace an enlarged ascending aortic aneurysm. Comorbidities included chronic renal failure requiring hemodialysis. Fourteen months after the Bentall procedure, the patient presented with sudden dyspnea and was transferred to another hospital. Upon suffering acute heart failure, the patient required mechanical ventilation and was transferred to our hospital for intubation. The patient subsequently developed severe pneumonia. As a result of prolonged ventilation, the patient underwent tracheostomy and wa...
      PubDate: Fri, 31 Mar 2023 16:34:52 +010
       
  • Food Protein-induced Enterocolitis Syndrome

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: Keio J Med. 2023 Jan 19. doi: 10.2302/kjm.2022-0016-IR. Online ahead of print.ABSTRACTFood protein-induced enterocolitis syndrome (FPIES) is a type of non-IgE-mediated gastrointestinal food allergy. FPIES is characterized by repetitive vomiting without classic IgE-mediated allergic skin or respiratory symptoms 1-4 h after causative food ingestion. The condition may be classified as acute or chronic, typical or atypical, and liquid or solid according to the course of symptoms, presence of IgE antibodies, and causative food, respectively. Since the development of international consensus guidelines in 2017, epidemiological studies have been conducted in many countries. FPIES is a relatively rare disease, with a prevalence of 0.015%-0.7%. However, the number of patients has been increasing in ...
      PubDate: Fri, 31 Mar 2023 16:34:52 +010
      DOI: 10.2302/kjm.2022-0016-ir. online ahead of print.abstractfood protein-induced enterocolitis syndrome
       
  • Reoperative Aortic Valve Replacement for Structural Valve Deterioration
           through a Lower Hemisternotomy after a Previous Bentall Procedure in a
           Patient with Tracheostomy

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: This report describes a reoperative aortic valve replacement (re-AVR) for structural valve deterioration (SVD) through a lower hemisternotomy. This procedure was performed on a 71-year-old man with a tracheostomy who had previously undergone a Bentall procedure with a bioprosthetic valve to replace an enlarged ascending aortic aneurysm. Comorbidities included chronic renal failure requiring hemodialysis. Fourteen months after the Bentall procedure, the patient presented with sudden dyspnea and was transferred to another hospital. Upon suffering acute heart failure, the patient required mechanical ventilation and was transferred to our hospital for intubation. The patient subsequently developed severe pneumonia. As a result of prolonged ventilation, the patient underwent tracheostomy and wa...
      PubDate: Fri, 31 Mar 2023 16:34:52 +010
       
  • Food Protein-induced Enterocolitis Syndrome

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: Keio J Med. 2023 Jan 19. doi: 10.2302/kjm.2022-0016-IR. Online ahead of print.ABSTRACTFood protein-induced enterocolitis syndrome (FPIES) is a type of non-IgE-mediated gastrointestinal food allergy. FPIES is characterized by repetitive vomiting without classic IgE-mediated allergic skin or respiratory symptoms 1-4 h after causative food ingestion. The condition may be classified as acute or chronic, typical or atypical, and liquid or solid according to the course of symptoms, presence of IgE antibodies, and causative food, respectively. Since the development of international consensus guidelines in 2017, epidemiological studies have been conducted in many countries. FPIES is a relatively rare disease, with a prevalence of 0.015%-0.7%. However, the number of patients has been increasing in ...
      PubDate: Fri, 31 Mar 2023 16:34:52 +010
      DOI: 10.2302/kjm.2022-0016-ir. online ahead of print.abstractfood protein-induced enterocolitis syndrome
       
  • Reoperative Aortic Valve Replacement for Structural Valve Deterioration
           through a Lower Hemisternotomy after a Previous Bentall Procedure in a
           Patient with Tracheostomy

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: This report describes a reoperative aortic valve replacement (re-AVR) for structural valve deterioration (SVD) through a lower hemisternotomy. This procedure was performed on a 71-year-old man with a tracheostomy who had previously undergone a Bentall procedure with a bioprosthetic valve to replace an enlarged ascending aortic aneurysm. Comorbidities included chronic renal failure requiring hemodialysis. Fourteen months after the Bentall procedure, the patient presented with sudden dyspnea and was transferred to another hospital. Upon suffering acute heart failure, the patient required mechanical ventilation and was transferred to our hospital for intubation. The patient subsequently developed severe pneumonia. As a result of prolonged ventilation, the patient underwent tracheostomy and wa...
      PubDate: Fri, 31 Mar 2023 16:34:52 +010
       
  • Food Protein-induced Enterocolitis Syndrome

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: Keio J Med. 2023 Jan 19. doi: 10.2302/kjm.2022-0016-IR. Online ahead of print.ABSTRACTFood protein-induced enterocolitis syndrome (FPIES) is a type of non-IgE-mediated gastrointestinal food allergy. FPIES is characterized by repetitive vomiting without classic IgE-mediated allergic skin or respiratory symptoms 1-4 h after causative food ingestion. The condition may be classified as acute or chronic, typical or atypical, and liquid or solid according to the course of symptoms, presence of IgE antibodies, and causative food, respectively. Since the development of international consensus guidelines in 2017, epidemiological studies have been conducted in many countries. FPIES is a relatively rare disease, with a prevalence of 0.015%-0.7%. However, the number of patients has been increasing in ...
      PubDate: Fri, 31 Mar 2023 16:34:52 +010
      DOI: 10.2302/kjm.2022-0016-ir. online ahead of print.abstractfood protein-induced enterocolitis syndrome
       
  • Reoperative Aortic Valve Replacement for Structural Valve Deterioration
           through a Lower Hemisternotomy after a Previous Bentall Procedure in a
           Patient with Tracheostomy

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: This report describes a reoperative aortic valve replacement (re-AVR) for structural valve deterioration (SVD) through a lower hemisternotomy. This procedure was performed on a 71-year-old man with a tracheostomy who had previously undergone a Bentall procedure with a bioprosthetic valve to replace an enlarged ascending aortic aneurysm. Comorbidities included chronic renal failure requiring hemodialysis. Fourteen months after the Bentall procedure, the patient presented with sudden dyspnea and was transferred to another hospital. Upon suffering acute heart failure, the patient required mechanical ventilation and was transferred to our hospital for intubation. The patient subsequently developed severe pneumonia. As a result of prolonged ventilation, the patient underwent tracheostomy and wa...
      PubDate: Fri, 31 Mar 2023 16:34:52 +010
       
  • Food Protein-induced Enterocolitis Syndrome

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: Keio J Med. 2023 Jan 19. doi: 10.2302/kjm.2022-0016-IR. Online ahead of print.ABSTRACTFood protein-induced enterocolitis syndrome (FPIES) is a type of non-IgE-mediated gastrointestinal food allergy. FPIES is characterized by repetitive vomiting without classic IgE-mediated allergic skin or respiratory symptoms 1-4 h after causative food ingestion. The condition may be classified as acute or chronic, typical or atypical, and liquid or solid according to the course of symptoms, presence of IgE antibodies, and causative food, respectively. Since the development of international consensus guidelines in 2017, epidemiological studies have been conducted in many countries. FPIES is a relatively rare disease, with a prevalence of 0.015%-0.7%. However, the number of patients has been increasing in ...
      PubDate: Fri, 31 Mar 2023 16:34:52 +010
      DOI: 10.2302/kjm.2022-0016-ir. online ahead of print.abstractfood protein-induced enterocolitis syndrome
       
  • Reoperative Aortic Valve Replacement for Structural Valve Deterioration
           through a Lower Hemisternotomy after a Previous Bentall Procedure in a
           Patient with Tracheostomy

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: This report describes a reoperative aortic valve replacement (re-AVR) for structural valve deterioration (SVD) through a lower hemisternotomy. This procedure was performed on a 71-year-old man with a tracheostomy who had previously undergone a Bentall procedure with a bioprosthetic valve to replace an enlarged ascending aortic aneurysm. Comorbidities included chronic renal failure requiring hemodialysis. Fourteen months after the Bentall procedure, the patient presented with sudden dyspnea and was transferred to another hospital. Upon suffering acute heart failure, the patient required mechanical ventilation and was transferred to our hospital for intubation. The patient subsequently developed severe pneumonia. As a result of prolonged ventilation, the patient underwent tracheostomy and wa...
      PubDate: Fri, 31 Mar 2023 16:34:52 +010
       
  • Food Protein-induced Enterocolitis Syndrome

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: Keio J Med. 2023 Jan 19. doi: 10.2302/kjm.2022-0016-IR. Online ahead of print.ABSTRACTFood protein-induced enterocolitis syndrome (FPIES) is a type of non-IgE-mediated gastrointestinal food allergy. FPIES is characterized by repetitive vomiting without classic IgE-mediated allergic skin or respiratory symptoms 1-4 h after causative food ingestion. The condition may be classified as acute or chronic, typical or atypical, and liquid or solid according to the course of symptoms, presence of IgE antibodies, and causative food, respectively. Since the development of international consensus guidelines in 2017, epidemiological studies have been conducted in many countries. FPIES is a relatively rare disease, with a prevalence of 0.015%-0.7%. However, the number of patients has been increasing in ...
      PubDate: Fri, 31 Mar 2023 16:34:52 +010
      DOI: 10.2302/kjm.2022-0016-ir. online ahead of print.abstractfood protein-induced enterocolitis syndrome
       
  • Reoperative Aortic Valve Replacement for Structural Valve Deterioration
           through a Lower Hemisternotomy after a Previous Bentall Procedure in a
           Patient with Tracheostomy

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: This report describes a reoperative aortic valve replacement (re-AVR) for structural valve deterioration (SVD) through a lower hemisternotomy. This procedure was performed on a 71-year-old man with a tracheostomy who had previously undergone a Bentall procedure with a bioprosthetic valve to replace an enlarged ascending aortic aneurysm. Comorbidities included chronic renal failure requiring hemodialysis. Fourteen months after the Bentall procedure, the patient presented with sudden dyspnea and was transferred to another hospital. Upon suffering acute heart failure, the patient required mechanical ventilation and was transferred to our hospital for intubation. The patient subsequently developed severe pneumonia. As a result of prolonged ventilation, the patient underwent tracheostomy and wa...
      PubDate: Fri, 31 Mar 2023 16:34:52 +010
       
  • Food Protein-induced Enterocolitis Syndrome

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: Keio J Med. 2023 Jan 19. doi: 10.2302/kjm.2022-0016-IR. Online ahead of print.ABSTRACTFood protein-induced enterocolitis syndrome (FPIES) is a type of non-IgE-mediated gastrointestinal food allergy. FPIES is characterized by repetitive vomiting without classic IgE-mediated allergic skin or respiratory symptoms 1-4 h after causative food ingestion. The condition may be classified as acute or chronic, typical or atypical, and liquid or solid according to the course of symptoms, presence of IgE antibodies, and causative food, respectively. Since the development of international consensus guidelines in 2017, epidemiological studies have been conducted in many countries. FPIES is a relatively rare disease, with a prevalence of 0.015%-0.7%. However, the number of patients has been increasing in ...
      PubDate: Fri, 31 Mar 2023 16:34:52 +010
      DOI: 10.2302/kjm.2022-0016-ir. online ahead of print.abstractfood protein-induced enterocolitis syndrome
       
  • Reoperative Aortic Valve Replacement for Structural Valve Deterioration
           through a Lower Hemisternotomy after a Previous Bentall Procedure in a
           Patient with Tracheostomy

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: This report describes a reoperative aortic valve replacement (re-AVR) for structural valve deterioration (SVD) through a lower hemisternotomy. This procedure was performed on a 71-year-old man with a tracheostomy who had previously undergone a Bentall procedure with a bioprosthetic valve to replace an enlarged ascending aortic aneurysm. Comorbidities included chronic renal failure requiring hemodialysis. Fourteen months after the Bentall procedure, the patient presented with sudden dyspnea and was transferred to another hospital. Upon suffering acute heart failure, the patient required mechanical ventilation and was transferred to our hospital for intubation. The patient subsequently developed severe pneumonia. As a result of prolonged ventilation, the patient underwent tracheostomy and wa...
      PubDate: Fri, 31 Mar 2023 16:34:52 +010
       
  • Food Protein-induced Enterocolitis Syndrome

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: Keio J Med. 2023 Jan 19. doi: 10.2302/kjm.2022-0016-IR. Online ahead of print.ABSTRACTFood protein-induced enterocolitis syndrome (FPIES) is a type of non-IgE-mediated gastrointestinal food allergy. FPIES is characterized by repetitive vomiting without classic IgE-mediated allergic skin or respiratory symptoms 1-4 h after causative food ingestion. The condition may be classified as acute or chronic, typical or atypical, and liquid or solid according to the course of symptoms, presence of IgE antibodies, and causative food, respectively. Since the development of international consensus guidelines in 2017, epidemiological studies have been conducted in many countries. FPIES is a relatively rare disease, with a prevalence of 0.015%-0.7%. However, the number of patients has been increasing in ...
      PubDate: Fri, 31 Mar 2023 16:34:52 +010
      DOI: 10.2302/kjm.2022-0016-ir. online ahead of print.abstractfood protein-induced enterocolitis syndrome
       
  • Reoperative Aortic Valve Replacement for Structural Valve Deterioration
           through a Lower Hemisternotomy after a Previous Bentall Procedure in a
           Patient with Tracheostomy

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: This report describes a reoperative aortic valve replacement (re-AVR) for structural valve deterioration (SVD) through a lower hemisternotomy. This procedure was performed on a 71-year-old man with a tracheostomy who had previously undergone a Bentall procedure with a bioprosthetic valve to replace an enlarged ascending aortic aneurysm. Comorbidities included chronic renal failure requiring hemodialysis. Fourteen months after the Bentall procedure, the patient presented with sudden dyspnea and was transferred to another hospital. Upon suffering acute heart failure, the patient required mechanical ventilation and was transferred to our hospital for intubation. The patient subsequently developed severe pneumonia. As a result of prolonged ventilation, the patient underwent tracheostomy and wa...
      PubDate: Fri, 31 Mar 2023 16:34:52 +010
       
  • Food Protein-induced Enterocolitis Syndrome

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: Keio J Med. 2023 Jan 19. doi: 10.2302/kjm.2022-0016-IR. Online ahead of print.ABSTRACTFood protein-induced enterocolitis syndrome (FPIES) is a type of non-IgE-mediated gastrointestinal food allergy. FPIES is characterized by repetitive vomiting without classic IgE-mediated allergic skin or respiratory symptoms 1-4 h after causative food ingestion. The condition may be classified as acute or chronic, typical or atypical, and liquid or solid according to the course of symptoms, presence of IgE antibodies, and causative food, respectively. Since the development of international consensus guidelines in 2017, epidemiological studies have been conducted in many countries. FPIES is a relatively rare disease, with a prevalence of 0.015%-0.7%. However, the number of patients has been increasing in ...
      PubDate: Fri, 31 Mar 2023 16:34:52 +010
      DOI: 10.2302/kjm.2022-0016-ir. online ahead of print.abstractfood protein-induced enterocolitis syndrome
       
  • Reoperative Aortic Valve Replacement for Structural Valve Deterioration
           through a Lower Hemisternotomy after a Previous Bentall Procedure in a
           Patient with Tracheostomy

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: This report describes a reoperative aortic valve replacement (re-AVR) for structural valve deterioration (SVD) through a lower hemisternotomy. This procedure was performed on a 71-year-old man with a tracheostomy who had previously undergone a Bentall procedure with a bioprosthetic valve to replace an enlarged ascending aortic aneurysm. Comorbidities included chronic renal failure requiring hemodialysis. Fourteen months after the Bentall procedure, the patient presented with sudden dyspnea and was transferred to another hospital. Upon suffering acute heart failure, the patient required mechanical ventilation and was transferred to our hospital for intubation. The patient subsequently developed severe pneumonia. As a result of prolonged ventilation, the patient underwent tracheostomy and wa...
      PubDate: Fri, 31 Mar 2023 16:34:52 +010
       
  • Food Protein-induced Enterocolitis Syndrome

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: Keio J Med. 2023 Jan 19. doi: 10.2302/kjm.2022-0016-IR. Online ahead of print.ABSTRACTFood protein-induced enterocolitis syndrome (FPIES) is a type of non-IgE-mediated gastrointestinal food allergy. FPIES is characterized by repetitive vomiting without classic IgE-mediated allergic skin or respiratory symptoms 1-4 h after causative food ingestion. The condition may be classified as acute or chronic, typical or atypical, and liquid or solid according to the course of symptoms, presence of IgE antibodies, and causative food, respectively. Since the development of international consensus guidelines in 2017, epidemiological studies have been conducted in many countries. FPIES is a relatively rare disease, with a prevalence of 0.015%-0.7%. However, the number of patients has been increasing in ...
      PubDate: Fri, 31 Mar 2023 16:34:52 +010
      DOI: 10.2302/kjm.2022-0016-ir. online ahead of print.abstractfood protein-induced enterocolitis syndrome
       
  • Reoperative Aortic Valve Replacement for Structural Valve Deterioration
           through a Lower Hemisternotomy after a Previous Bentall Procedure in a
           Patient with Tracheostomy

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: This report describes a reoperative aortic valve replacement (re-AVR) for structural valve deterioration (SVD) through a lower hemisternotomy. This procedure was performed on a 71-year-old man with a tracheostomy who had previously undergone a Bentall procedure with a bioprosthetic valve to replace an enlarged ascending aortic aneurysm. Comorbidities included chronic renal failure requiring hemodialysis. Fourteen months after the Bentall procedure, the patient presented with sudden dyspnea and was transferred to another hospital. Upon suffering acute heart failure, the patient required mechanical ventilation and was transferred to our hospital for intubation. The patient subsequently developed severe pneumonia. As a result of prolonged ventilation, the patient underwent tracheostomy and wa...
      PubDate: Fri, 31 Mar 2023 16:34:52 +010
       
  • Food Protein-induced Enterocolitis Syndrome

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: Keio J Med. 2023 Jan 19. doi: 10.2302/kjm.2022-0016-IR. Online ahead of print.ABSTRACTFood protein-induced enterocolitis syndrome (FPIES) is a type of non-IgE-mediated gastrointestinal food allergy. FPIES is characterized by repetitive vomiting without classic IgE-mediated allergic skin or respiratory symptoms 1-4 h after causative food ingestion. The condition may be classified as acute or chronic, typical or atypical, and liquid or solid according to the course of symptoms, presence of IgE antibodies, and causative food, respectively. Since the development of international consensus guidelines in 2017, epidemiological studies have been conducted in many countries. FPIES is a relatively rare disease, with a prevalence of 0.015%-0.7%. However, the number of patients has been increasing in ...
      PubDate: Fri, 31 Mar 2023 16:34:52 +010
      DOI: 10.2302/kjm.2022-0016-ir. online ahead of print.abstractfood protein-induced enterocolitis syndrome
       
  • Reoperative Aortic Valve Replacement for Structural Valve Deterioration
           through a Lower Hemisternotomy after a Previous Bentall Procedure in a
           Patient with Tracheostomy

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: This report describes a reoperative aortic valve replacement (re-AVR) for structural valve deterioration (SVD) through a lower hemisternotomy. This procedure was performed on a 71-year-old man with a tracheostomy who had previously undergone a Bentall procedure with a bioprosthetic valve to replace an enlarged ascending aortic aneurysm. Comorbidities included chronic renal failure requiring hemodialysis. Fourteen months after the Bentall procedure, the patient presented with sudden dyspnea and was transferred to another hospital. Upon suffering acute heart failure, the patient required mechanical ventilation and was transferred to our hospital for intubation. The patient subsequently developed severe pneumonia. As a result of prolonged ventilation, the patient underwent tracheostomy and wa...
      PubDate: Fri, 31 Mar 2023 16:34:52 +010
       
  • Food Protein-induced Enterocolitis Syndrome

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: Keio J Med. 2023 Jan 19. doi: 10.2302/kjm.2022-0016-IR. Online ahead of print.ABSTRACTFood protein-induced enterocolitis syndrome (FPIES) is a type of non-IgE-mediated gastrointestinal food allergy. FPIES is characterized by repetitive vomiting without classic IgE-mediated allergic skin or respiratory symptoms 1-4 h after causative food ingestion. The condition may be classified as acute or chronic, typical or atypical, and liquid or solid according to the course of symptoms, presence of IgE antibodies, and causative food, respectively. Since the development of international consensus guidelines in 2017, epidemiological studies have been conducted in many countries. FPIES is a relatively rare disease, with a prevalence of 0.015%-0.7%. However, the number of patients has been increasing in ...
      PubDate: Fri, 31 Mar 2023 16:34:52 +010
      DOI: 10.2302/kjm.2022-0016-ir. online ahead of print.abstractfood protein-induced enterocolitis syndrome
       
  • Reoperative Aortic Valve Replacement for Structural Valve Deterioration
           through a Lower Hemisternotomy after a Previous Bentall Procedure in a
           Patient with Tracheostomy

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: This report describes a reoperative aortic valve replacement (re-AVR) for structural valve deterioration (SVD) through a lower hemisternotomy. This procedure was performed on a 71-year-old man with a tracheostomy who had previously undergone a Bentall procedure with a bioprosthetic valve to replace an enlarged ascending aortic aneurysm. Comorbidities included chronic renal failure requiring hemodialysis. Fourteen months after the Bentall procedure, the patient presented with sudden dyspnea and was transferred to another hospital. Upon suffering acute heart failure, the patient required mechanical ventilation and was transferred to our hospital for intubation. The patient subsequently developed severe pneumonia. As a result of prolonged ventilation, the patient underwent tracheostomy and wa...
      PubDate: Fri, 31 Mar 2023 16:34:52 +010
       
  • Food Protein-induced Enterocolitis Syndrome

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: Keio J Med. 2023 Jan 19. doi: 10.2302/kjm.2022-0016-IR. Online ahead of print.ABSTRACTFood protein-induced enterocolitis syndrome (FPIES) is a type of non-IgE-mediated gastrointestinal food allergy. FPIES is characterized by repetitive vomiting without classic IgE-mediated allergic skin or respiratory symptoms 1-4 h after causative food ingestion. The condition may be classified as acute or chronic, typical or atypical, and liquid or solid according to the course of symptoms, presence of IgE antibodies, and causative food, respectively. Since the development of international consensus guidelines in 2017, epidemiological studies have been conducted in many countries. FPIES is a relatively rare disease, with a prevalence of 0.015%-0.7%. However, the number of patients has been increasing in ...
      PubDate: Fri, 31 Mar 2023 16:34:52 +010
      DOI: 10.2302/kjm.2022-0016-ir. online ahead of print.abstractfood protein-induced enterocolitis syndrome
       
  • Reoperative Aortic Valve Replacement for Structural Valve Deterioration
           through a Lower Hemisternotomy after a Previous Bentall Procedure in a
           Patient with Tracheostomy

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: This report describes a reoperative aortic valve replacement (re-AVR) for structural valve deterioration (SVD) through a lower hemisternotomy. This procedure was performed on a 71-year-old man with a tracheostomy who had previously undergone a Bentall procedure with a bioprosthetic valve to replace an enlarged ascending aortic aneurysm. Comorbidities included chronic renal failure requiring hemodialysis. Fourteen months after the Bentall procedure, the patient presented with sudden dyspnea and was transferred to another hospital. Upon suffering acute heart failure, the patient required mechanical ventilation and was transferred to our hospital for intubation. The patient subsequently developed severe pneumonia. As a result of prolonged ventilation, the patient underwent tracheostomy and wa...
      PubDate: Fri, 31 Mar 2023 16:34:52 +010
       
  • Food Protein-induced Enterocolitis Syndrome

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: Keio J Med. 2023 Jan 19. doi: 10.2302/kjm.2022-0016-IR. Online ahead of print.ABSTRACTFood protein-induced enterocolitis syndrome (FPIES) is a type of non-IgE-mediated gastrointestinal food allergy. FPIES is characterized by repetitive vomiting without classic IgE-mediated allergic skin or respiratory symptoms 1-4 h after causative food ingestion. The condition may be classified as acute or chronic, typical or atypical, and liquid or solid according to the course of symptoms, presence of IgE antibodies, and causative food, respectively. Since the development of international consensus guidelines in 2017, epidemiological studies have been conducted in many countries. FPIES is a relatively rare disease, with a prevalence of 0.015%-0.7%. However, the number of patients has been increasing in ...
      PubDate: Fri, 31 Mar 2023 16:34:52 +010
      DOI: 10.2302/kjm.2022-0016-ir. online ahead of print.abstractfood protein-induced enterocolitis syndrome
       
  • Reoperative Aortic Valve Replacement for Structural Valve Deterioration
           through a Lower Hemisternotomy after a Previous Bentall Procedure in a
           Patient with Tracheostomy

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: This report describes a reoperative aortic valve replacement (re-AVR) for structural valve deterioration (SVD) through a lower hemisternotomy. This procedure was performed on a 71-year-old man with a tracheostomy who had previously undergone a Bentall procedure with a bioprosthetic valve to replace an enlarged ascending aortic aneurysm. Comorbidities included chronic renal failure requiring hemodialysis. Fourteen months after the Bentall procedure, the patient presented with sudden dyspnea and was transferred to another hospital. Upon suffering acute heart failure, the patient required mechanical ventilation and was transferred to our hospital for intubation. The patient subsequently developed severe pneumonia. As a result of prolonged ventilation, the patient underwent tracheostomy and wa...
      PubDate: Fri, 31 Mar 2023 16:34:52 +010
       
  • Food Protein-induced Enterocolitis Syndrome

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: Keio J Med. 2023 Jan 19. doi: 10.2302/kjm.2022-0016-IR. Online ahead of print.ABSTRACTFood protein-induced enterocolitis syndrome (FPIES) is a type of non-IgE-mediated gastrointestinal food allergy. FPIES is characterized by repetitive vomiting without classic IgE-mediated allergic skin or respiratory symptoms 1-4 h after causative food ingestion. The condition may be classified as acute or chronic, typical or atypical, and liquid or solid according to the course of symptoms, presence of IgE antibodies, and causative food, respectively. Since the development of international consensus guidelines in 2017, epidemiological studies have been conducted in many countries. FPIES is a relatively rare disease, with a prevalence of 0.015%-0.7%. However, the number of patients has been increasing in ...
      PubDate: Fri, 31 Mar 2023 16:34:52 +010
      DOI: 10.2302/kjm.2022-0016-ir. online ahead of print.abstractfood protein-induced enterocolitis syndrome
       
  • Age Group Differences in Daily Life Changes among Community Residents
           during the COVID-19 Pandemic: A Pilot Study on Intergenerational
           Comparison

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: This study investigated lifestyle changes and the self-reported mental health status of Japanese community residents during the COVID-19 pandemic. Differences in demography, daily lifestyle changes, and approaches to problem solving were analyzed in two age cohorts (<60 vs ≥60 years). The prevalence of moderate/increased psychological distress was 31.7%, with no significant difference between the cohorts. Compared with the pre-COVID-19 era, more than 80% of the participants stopped eating out and spent more time at home, and more than 70% used public transport less frequently. There were significant differences between the cohorts for the time spent at home, opportunities to eat meals outside of home, and shopping in stores. Participants aged under 60 years were less likely to use tel...
      PubDate: Fri, 31 Mar 2023 16:34:52 +010
       
  • In Vivo Intestinal Research Using Organoid Transplantation

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: Keio J Med. 2022 Dec 25;71(4):73-81. doi: 10.2302/kjm.2022-0019-IR. Epub 2022 Dec 1.ABSTRACTOur understanding of the biology of the intestinal epithelium has advanced since the establishment of an organoid culture system. Although organoids have enabled investigation of the mechanism of self-renewal of human intestinal stem cells in vitro, it remains difficult to clarify the behavior of human normal and diseased intestinal epithelium in vivo. Recently, we developed a xenotransplantation system in which human intestinal organoids are engrafted onto epithelium-depleted mouse colons. This xenograft recapitulated the original tissue structures. Upon xenotransplantation, normal colon organoids developed normal colon crypt structures without tumorigenesis, whereas tumor-derived organoids formed ...
      PubDate: Fri, 31 Mar 2023 16:34:52 +010
      DOI: 10.2302/kjm.2022-0019-ir. epub 2022 dec 1.abstractour understanding of the biology of the intestinal
       
  • Targeting Tumor Microenvironment in Liver Cancers: Rationale, Current
           Progress, and Future Perspective

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: Keio J Med. 2022;71(3):71. doi: 10.2302/kjm.71-004-ABST.ABSTRACTSurgical treatments offer the chance for cure in primary or metastatic liver cancers. However, many patients experience disease progression after surgical interventions, or cannot undergo surgery as they present with unresectable disease at diagnosis. In such cases, available treatment options (local and systemic) have been limited in efficacy, which led to dismal survival rates in advanced hepatocellular carcinoma (HCC), intrahepatic colangiocarcinoma (ICC) or metastatic pancreatic ductal adenocarcinoma (PDAC). More recent developments in oncology have offered renewed hope for advanced liver cancer patients. Hypofractionated radiation has shown feasibility and promise in unresectable setting, and is now being tested in a rand...
      PubDate: Fri, 31 Mar 2023 16:34:52 +010
      DOI: 10.2302/kjm.71-004-abst.abstractsurgical treatments offer the chance for cure in primary or metastat
       
  • Dissecting the Roles of Innate Cells in the Skin and Intractable Skin
           Diseases

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: Keio J Med. 2022;71(2):53. doi: 10.2302/kjm.71-003-ABST.ABSTRACTThe skin is not merely a physical barrier but also an active immunological interface, exposed to various external stimuli including microbes. Over the recent years, our laboratory has defined hair follicles as control towers that regulates immune cells residing in the skin. Hair follicles produce chemokines and cytokines that are crucial for the localization and tissue-residency of immune cells including the Langerhans cells, resident memory T cells, and innate lymphoid cells. We also discovered that disruption of the ADAM17-EGF receptor axis and ADAM10-Notch signaling axis leads to dysbiosis on the skin surface and in the hair follicles, respectively. The former leads to microbiome predominance of Staphylococcus aureus and re...
      PubDate: Fri, 31 Mar 2023 16:34:52 +010
      DOI: 10.2302/kjm.71-003-abst.abstractthe skin is not merely a physical barrier but also an active immunol
       
  • Serum Neurogranin Measurement as a Biomarker of Central Nervous System
           Infections: A Preliminary Study

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: In conclusion, it may be useful to measure blood neurogranin levels in patients suspected of having central nervous system infections, especially in those for whom computed tomography, magnetic resonance imaging, or lumbar puncture cannot be performed.PMID:35718469
      DOI :10.2302/kjm.2021-0019-OA (Source: The Keio Journal of Medicine)
      PubDate: Fri, 31 Mar 2023 16:34:52 +010
       
  • Brain-machine Interface (BMI)-based Neurorehabilitation for Post-stroke
           Upper Limb Paralysis

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: Keio J Med. 2022 Jun 17. doi: 10.2302/kjm.2022-0002-OA. Online ahead of print.ABSTRACTBecause recovery from upper limb paralysis after stroke is challenging, compensatory approaches have been the main focus of upper limb rehabilitation. However, based on fundamental and clinical research indicating that the brain has a far greater potential for plastic change than previously thought, functional restorative approaches have become increasingly common. Among such interventions, constraint-induced movement therapy, task-specific training, robotic therapy, neuromuscular electrical stimulation (NMES), mental practice, mirror therapy, and bilateral arm training are recommended in recently published stroke guidelines. For severe upper limb paralysis, however, no effective therapy has yet been esta...
      PubDate: Fri, 31 Mar 2023 16:34:52 +010
      DOI: 10.2302/kjm.2022-0002-oa. online ahead of print.abstractbecause recovery from upper limb paralysis a
       
  • Serum Neurogranin Measurement as a Biomarker of Central Nervous System
           Infections: A Preliminary Study

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: In conclusion, it may be useful to measure blood neurogranin levels in patients suspected of having central nervous system infections, especially in those for whom computed tomography, magnetic resonance imaging, or lumbar puncture cannot be performed.PMID:35718469
      DOI :10.2302/kjm.2021-0019-OA (Source: The Keio Journal of Medicine)
      PubDate: Fri, 31 Mar 2023 16:34:52 +010
       
  • Brain-machine Interface (BMI)-based Neurorehabilitation for Post-stroke
           Upper Limb Paralysis

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: Keio J Med. 2022 Jun 17. doi: 10.2302/kjm.2022-0002-OA. Online ahead of print.ABSTRACTBecause recovery from upper limb paralysis after stroke is challenging, compensatory approaches have been the main focus of upper limb rehabilitation. However, based on fundamental and clinical research indicating that the brain has a far greater potential for plastic change than previously thought, functional restorative approaches have become increasingly common. Among such interventions, constraint-induced movement therapy, task-specific training, robotic therapy, neuromuscular electrical stimulation (NMES), mental practice, mirror therapy, and bilateral arm training are recommended in recently published stroke guidelines. For severe upper limb paralysis, however, no effective therapy has yet been esta...
      PubDate: Fri, 31 Mar 2023 16:34:52 +010
      DOI: 10.2302/kjm.2022-0002-oa. online ahead of print.abstractbecause recovery from upper limb paralysis a
       
  • Serum Neurogranin Measurement as a Biomarker of Central Nervous System
           Infections: A Preliminary Study

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: In conclusion, it may be useful to measure blood neurogranin levels in patients suspected of having central nervous system infections, especially in those for whom computed tomography, magnetic resonance imaging, or lumbar puncture cannot be performed.PMID:35718469
      DOI :10.2302/kjm.2021-0019-OA (Source: The Keio Journal of Medicine)
      PubDate: Fri, 31 Mar 2023 16:34:52 +010
       
  • Brain-machine Interface (BMI)-based Neurorehabilitation for Post-stroke
           Upper Limb Paralysis

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: Keio J Med. 2022 Jun 17. doi: 10.2302/kjm.2022-0002-OA. Online ahead of print.ABSTRACTBecause recovery from upper limb paralysis after stroke is challenging, compensatory approaches have been the main focus of upper limb rehabilitation. However, based on fundamental and clinical research indicating that the brain has a far greater potential for plastic change than previously thought, functional restorative approaches have become increasingly common. Among such interventions, constraint-induced movement therapy, task-specific training, robotic therapy, neuromuscular electrical stimulation (NMES), mental practice, mirror therapy, and bilateral arm training are recommended in recently published stroke guidelines. For severe upper limb paralysis, however, no effective therapy has yet been esta...
      PubDate: Fri, 31 Mar 2023 16:34:52 +010
      DOI: 10.2302/kjm.2022-0002-oa. online ahead of print.abstractbecause recovery from upper limb paralysis a
       
  • Serum Neurogranin Measurement as a Biomarker of Central Nervous System
           Infections: A Preliminary Study

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: In conclusion, it may be useful to measure blood neurogranin levels in patients suspected of having central nervous system infections, especially in those for whom computed tomography, magnetic resonance imaging, or lumbar puncture cannot be performed.PMID:35718469
      DOI :10.2302/kjm.2021-0019-OA (Source: The Keio Journal of Medicine)
      PubDate: Fri, 31 Mar 2023 16:34:52 +010
       
  • Brain-machine Interface (BMI)-based Neurorehabilitation for Post-stroke
           Upper Limb Paralysis

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: Keio J Med. 2022 Jun 17. doi: 10.2302/kjm.2022-0002-OA. Online ahead of print.ABSTRACTBecause recovery from upper limb paralysis after stroke is challenging, compensatory approaches have been the main focus of upper limb rehabilitation. However, based on fundamental and clinical research indicating that the brain has a far greater potential for plastic change than previously thought, functional restorative approaches have become increasingly common. Among such interventions, constraint-induced movement therapy, task-specific training, robotic therapy, neuromuscular electrical stimulation (NMES), mental practice, mirror therapy, and bilateral arm training are recommended in recently published stroke guidelines. For severe upper limb paralysis, however, no effective therapy has yet been esta...
      PubDate: Fri, 31 Mar 2023 16:34:52 +010
      DOI: 10.2302/kjm.2022-0002-oa. online ahead of print.abstractbecause recovery from upper limb paralysis a
       
  • Serum Neurogranin Measurement as a Biomarker of Central Nervous System
           Infections: A Preliminary Study

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: In conclusion, it may be useful to measure blood neurogranin levels in patients suspected of having central nervous system infections, especially in those for whom computed tomography, magnetic resonance imaging, or lumbar puncture cannot be performed.PMID:35718469
      DOI :10.2302/kjm.2021-0019-OA (Source: The Keio Journal of Medicine)
      PubDate: Fri, 31 Mar 2023 16:34:52 +010
       
  • Brain-machine Interface (BMI)-based Neurorehabilitation for Post-stroke
           Upper Limb Paralysis

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: Keio J Med. 2022 Jun 17. doi: 10.2302/kjm.2022-0002-OA. Online ahead of print.ABSTRACTBecause recovery from upper limb paralysis after stroke is challenging, compensatory approaches have been the main focus of upper limb rehabilitation. However, based on fundamental and clinical research indicating that the brain has a far greater potential for plastic change than previously thought, functional restorative approaches have become increasingly common. Among such interventions, constraint-induced movement therapy, task-specific training, robotic therapy, neuromuscular electrical stimulation (NMES), mental practice, mirror therapy, and bilateral arm training are recommended in recently published stroke guidelines. For severe upper limb paralysis, however, no effective therapy has yet been esta...
      PubDate: Fri, 31 Mar 2023 16:34:52 +010
      DOI: 10.2302/kjm.2022-0002-oa. online ahead of print.abstractbecause recovery from upper limb paralysis a
       
  • Serum Neurogranin Measurement as a Biomarker of Central Nervous System
           Infections: A Preliminary Study

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: In conclusion, it may be useful to measure blood neurogranin levels in patients suspected of having central nervous system infections, especially in those for whom computed tomography, magnetic resonance imaging, or lumbar puncture cannot be performed.PMID:35718469
      DOI :10.2302/kjm.2021-0019-OA (Source: The Keio Journal of Medicine)
      PubDate: Fri, 31 Mar 2023 16:34:52 +010
       
  • Brain-machine Interface (BMI)-based Neurorehabilitation for Post-stroke
           Upper Limb Paralysis

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: Keio J Med. 2022 Jun 17. doi: 10.2302/kjm.2022-0002-OA. Online ahead of print.ABSTRACTBecause recovery from upper limb paralysis after stroke is challenging, compensatory approaches have been the main focus of upper limb rehabilitation. However, based on fundamental and clinical research indicating that the brain has a far greater potential for plastic change than previously thought, functional restorative approaches have become increasingly common. Among such interventions, constraint-induced movement therapy, task-specific training, robotic therapy, neuromuscular electrical stimulation (NMES), mental practice, mirror therapy, and bilateral arm training are recommended in recently published stroke guidelines. For severe upper limb paralysis, however, no effective therapy has yet been esta...
      PubDate: Fri, 31 Mar 2023 16:34:52 +010
      DOI: 10.2302/kjm.2022-0002-oa. online ahead of print.abstractbecause recovery from upper limb paralysis a
       
  • Developing mRNA for Therapy

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: Keio J Med. 2022;71(1):31. doi: 10.2302/kjm.71-001-ABST.ABSTRACTMessenger RNA was discovered in 1961 and it took 60 years until the first mRNA became FDA-approved product in the form of COVID-19 mRNA vaccine. During those years a lot of progress has been made by hundreds of scientists. It was 1978 when the first-time isolated mRNA delivered into mammalian cells produced the encoded protein. In vitro transcription introduced in 1984 made it possible to generate any desired mRNA from the encoding plasmid using phage RNA polymerases. In the early 90s mRNA was used for therapy as well as vaccine against infectious diseases and cancer. Inflammatory nature of the mRNAs limited their in vivo use. Replacing uridine with pseudouridine made the mRNA non-immunogenic, more stable and highly translatab...
      PubDate: Fri, 31 Mar 2023 16:34:52 +010
      DOI: 10.2302/kjm.71-001-abst.abstractmessenger rna was discovered in 1961 and it took 60 years until the
       
  • Molecular mechanisms of building blocks of life towards medicinal
           applications

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: Keio J Med. 2022;71(1):32. doi: 10.2302/kjm.71-002-ABST.ABSTRACTMembrane and membrane-spanning proteins, and non-coding RNA are biomolecules to play central roles in beginning of life and distinguishing higher-order eukaryotes. We have determined the structures of membrane protein-lipids complexes and non-coding RNA-protein complexes by X-ray crystallography and Cryo-EM single particle analysis, and combined with complementary functional analyses, elucidate their molecular mechanisms at atomic resolutions, to promote creating drugs and medical technologies with two venture companies.PMID:35342150
      DOI :10.2302/kjm.71-002-ABST (Source: The Keio Journal of Medicine)
      PubDate: Fri, 31 Mar 2023 16:34:52 +010
       
  • Developing mRNA for Therapy

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: Keio J Med. 2022;71(1):31. doi: 10.2302/kjm.71-001-ABST.ABSTRACTMessenger RNA was discovered in 1961 and it took 60 years until the first mRNA became FDA-approved product in the form of COVID-19 mRNA vaccine. During those years a lot of progress has been made by hundreds of scientists. It was 1978 when the first-time isolated mRNA delivered into mammalian cells produced the encoded protein. In vitro transcription introduced in 1984 made it possible to generate any desired mRNA from the encoding plasmid using phage RNA polymerases. In the early 90s mRNA was used for therapy as well as vaccine against infectious diseases and cancer. Inflammatory nature of the mRNAs limited their in vivo use. Replacing uridine with pseudouridine made the mRNA non-immunogenic, more stable and highly translatab...
      PubDate: Fri, 31 Mar 2023 16:34:52 +010
      DOI: 10.2302/kjm.71-001-abst.abstractmessenger rna was discovered in 1961 and it took 60 years until the
       
  • Molecular mechanisms of building blocks of life towards medicinal
           applications

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: Keio J Med. 2022;71(1):32. doi: 10.2302/kjm.71-002-ABST.ABSTRACTMembrane and membrane-spanning proteins, and non-coding RNA are biomolecules to play central roles in beginning of life and distinguishing higher-order eukaryotes. We have determined the structures of membrane protein-lipids complexes and non-coding RNA-protein complexes by X-ray crystallography and Cryo-EM single particle analysis, and combined with complementary functional analyses, elucidate their molecular mechanisms at atomic resolutions, to promote creating drugs and medical technologies with two venture companies.PMID:35342150
      DOI :10.2302/kjm.71-002-ABST (Source: The Keio Journal of Medicine)
      PubDate: Fri, 31 Mar 2023 16:34:52 +010
       
  • Developing mRNA for Therapy

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: Keio J Med. 2022;71(1):31. doi: 10.2302/kjm.71-001-ABST.ABSTRACTMessenger RNA was discovered in 1961 and it took 60 years until the first mRNA became FDA-approved product in the form of COVID-19 mRNA vaccine. During those years a lot of progress has been made by hundreds of scientists. It was 1978 when the first-time isolated mRNA delivered into mammalian cells produced the encoded protein. In vitro transcription introduced in 1984 made it possible to generate any desired mRNA from the encoding plasmid using phage RNA polymerases. In the early 90s mRNA was used for therapy as well as vaccine against infectious diseases and cancer. Inflammatory nature of the mRNAs limited their in vivo use. Replacing uridine with pseudouridine made the mRNA non-immunogenic, more stable and highly translatab...
      PubDate: Fri, 31 Mar 2023 16:34:52 +010
      DOI: 10.2302/kjm.71-001-abst.abstractmessenger rna was discovered in 1961 and it took 60 years until the
       
  • Molecular mechanisms of building blocks of life towards medicinal
           applications

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: Keio J Med. 2022;71(1):32. doi: 10.2302/kjm.71-002-ABST.ABSTRACTMembrane and membrane-spanning proteins, and non-coding RNA are biomolecules to play central roles in beginning of life and distinguishing higher-order eukaryotes. We have determined the structures of membrane protein-lipids complexes and non-coding RNA-protein complexes by X-ray crystallography and Cryo-EM single particle analysis, and combined with complementary functional analyses, elucidate their molecular mechanisms at atomic resolutions, to promote creating drugs and medical technologies with two venture companies.PMID:35342150
      DOI :10.2302/kjm.71-002-ABST (Source: The Keio Journal of Medicine)
      PubDate: Fri, 31 Mar 2023 16:34:52 +010
       
  • Developing mRNA for Therapy

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: Keio J Med. 2022;71(1):31. doi: 10.2302/kjm.71-001-ABST.ABSTRACTMessenger RNA was discovered in 1961 and it took 60 years until the first mRNA became FDA-approved product in the form of COVID-19 mRNA vaccine. During those years a lot of progress has been made by hundreds of scientists. It was 1978 when the first-time isolated mRNA delivered into mammalian cells produced the encoded protein. In vitro transcription introduced in 1984 made it possible to generate any desired mRNA from the encoding plasmid using phage RNA polymerases. In the early 90s mRNA was used for therapy as well as vaccine against infectious diseases and cancer. Inflammatory nature of the mRNAs limited their in vivo use. Replacing uridine with pseudouridine made the mRNA non-immunogenic, more stable and highly translatab...
      PubDate: Fri, 31 Mar 2023 16:34:52 +010
      DOI: 10.2302/kjm.71-001-abst.abstractmessenger rna was discovered in 1961 and it took 60 years until the
       
  • Molecular mechanisms of building blocks of life towards medicinal
           applications

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: Keio J Med. 2022;71(1):32. doi: 10.2302/kjm.71-002-ABST.ABSTRACTMembrane and membrane-spanning proteins, and non-coding RNA are biomolecules to play central roles in beginning of life and distinguishing higher-order eukaryotes. We have determined the structures of membrane protein-lipids complexes and non-coding RNA-protein complexes by X-ray crystallography and Cryo-EM single particle analysis, and combined with complementary functional analyses, elucidate their molecular mechanisms at atomic resolutions, to promote creating drugs and medical technologies with two venture companies.PMID:35342150
      DOI :10.2302/kjm.71-002-ABST (Source: The Keio Journal of Medicine)
      PubDate: Fri, 31 Mar 2023 16:34:52 +010
       
  • Developing mRNA for Therapy

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: Keio J Med. 2022;71(1):31. doi: 10.2302/kjm.71-001-ABST.ABSTRACTMessenger RNA was discovered in 1961 and it took 60 years until the first mRNA became FDA-approved product in the form of COVID-19 mRNA vaccine. During those years a lot of progress has been made by hundreds of scientists. It was 1978 when the first-time isolated mRNA delivered into mammalian cells produced the encoded protein. In vitro transcription introduced in 1984 made it possible to generate any desired mRNA from the encoding plasmid using phage RNA polymerases. In the early 90s mRNA was used for therapy as well as vaccine against infectious diseases and cancer. Inflammatory nature of the mRNAs limited their in vivo use. Replacing uridine with pseudouridine made the mRNA non-immunogenic, more stable and highly translatab...
      PubDate: Fri, 31 Mar 2023 16:34:52 +010
      DOI: 10.2302/kjm.71-001-abst.abstractmessenger rna was discovered in 1961 and it took 60 years until the
       
  • Molecular mechanisms of building blocks of life towards medicinal
           applications

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: Keio J Med. 2022;71(1):32. doi: 10.2302/kjm.71-002-ABST.ABSTRACTMembrane and membrane-spanning proteins, and non-coding RNA are biomolecules to play central roles in beginning of life and distinguishing higher-order eukaryotes. We have determined the structures of membrane protein-lipids complexes and non-coding RNA-protein complexes by X-ray crystallography and Cryo-EM single particle analysis, and combined with complementary functional analyses, elucidate their molecular mechanisms at atomic resolutions, to promote creating drugs and medical technologies with two venture companies.PMID:35342150
      DOI :10.2302/kjm.71-002-ABST (Source: The Keio Journal of Medicine)
      PubDate: Fri, 31 Mar 2023 16:34:52 +010
       
  • Developing mRNA for Therapy

    • Free pre-print version: Loading...

      Authors: The Keio Journal of Medicine
      Abstract: Keio J Med. 2022;71(1):31. doi: 10.2302/kjm.71-001-ABST.ABSTRACTMessenger RNA was discovered in 1961 and it took 60 years until the first mRNA became FDA-approved product in the form of COVID-19 mRNA vaccine. During those years a lot of progress has been made by hundreds of scientists. It was 1978 when the first-time isolated mRNA delivered into mammalian cells produced the encoded protein. In vitro transcription introduced in 1984 made it possible to generate any desired mRNA from the encoding plasmid using phage RNA polymerases. In the early 90s mRNA was used for therapy as well as vaccine against infectious diseases and cancer. Inflammatory nature of the mRNAs limited their in vivo use. Replacing uridine with pseudouridine made the mRNA non-immunogenic, more stable and highly translatab...
      PubDate: Fri, 31 Mar 2023 16:34:52 +010
      DOI: 10.2302/kjm.71-001-abst.abstractmessenger rna was discovered in 1961 and it took 60 years until the
       
 
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