| Publisher: Hayat Sağlık ve Sosyal Hizmetler Vakfı (Total: 1 journals) [Sort by number of followers]
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Anatolian Clinic the Journal of Medical Sciences
Number of Followers: 0  Open Access journalISSN (Print) 2149-5254 - ISSN (Online) 2458-8849 Published by Hayat Sağlık ve Sosyal Hizmetler Vakfı  [1 journal]
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- Medicine in philately: Pandemics from past to present
Authors: Mehtap PEKESEN; Ahmet Doğan ATAMAN, Ahmet ÖZDİNÇ
Abstract: Aim: There have been many pandemics that have left deep traces in human history. Many pandemics have caused crises in societies and negative consequences on health, the economy, social, and global security. Pandemics are foreseen to exist in the future as they have in the past and present. Therefore, examining past pandemics can serve to better understand, analyze and manage future pandemic processes. From this point of view, this article aims to emphasize past pandemics through philately medicine, draw attention to possible pandemics in the future, and raise awareness about the precautions to be taken.Methods: This article aims to describe the discovery and development of pandemics around the world through historical stamps, postal history, and other related items. Philately is the study of stamps, postal history, and other related items. But philately is much more than stamp collecting. Philately involves the study of the design and educational impact of the material. This article presents the history of medicine stamps produced worldwide from the past to the present to highlight the history of the pandemic. The stamp captions are based on a scan of the 6-volume Scott Catalog of Standard Postage Stamps (2017). The copyright of the stamps used in the article belongs to the philatelist authorResults: This article presents pandemic stamps produced worldwide between 1962 and 2020. In the article, a total of 17 philatelic materials (historical stamps) are presented on the subject of describing the prehistoric life of people, infectious diseases that cause pandemics, transmission routes of epidemics, prevention, treatment approaches, losses in pandemics and struggles against pandemics.Conclusion: This research provides an overview of the development and history of pandemics around the world, using philatelic medicine materials produced worldwide during pandemics from the past to the present.
PubDate: Fri, 20 Jan 2023 00:00:00 +030
- Abdulhak Molla and the beginning of smallpox vaccination at the Tibbiye
Authors: Mahmut Alpertunga KARA
Abstract: Aim: The contributions of Chief Physician Abdulhak Molla to the modernization of Turkish medicine and the beginning of smallpox vaccine application in Medical School were examined.Methods: The basic sources of the period and the monographs on the subject were reviewed and cross reading was made.Results: Abdülhak Molla held high-level positions during the years when Turkey was undergoing a critical transformation towards modernization. In addition to his personal characteristics, his environment and especially his brotherhood of Mustafa Behçet Efendi played a role in Molla’s activities. The two brothers played a role in the establishment of Tıbbiye, a pioneering institution in the modernization of both medical education and health services, with their successive missions and shared visions. The start of smallpox vaccination exemplifies the results of the transformation experienced in this period.Conclusion: Abdülhak Molla has contributed to Turkish medicine by maintaining the vision of modernization during the transformation process he has been involved in.
PubDate: Fri, 20 Jan 2023 00:00:00 +030
- Effects of chronic administration of thymoquinone on penicillin induced
epileptiform activity in rats
Authors: Ersin BEYAZÇİÇEK; Duru Aslıhan AVCİ, Özge BEYAZÇİÇEK
Abstract: Aim: Thymoquinone (TQ) is derived from Nigella Sativa (NS) which is a traditional medicinal plant used as a spice, and medication in traditional medicine. This study aims to investigate the chronic effects of TQ, which has been shown anticancer, antioxidant, and neuroprotective effects, on experimental penicillin-induced epilepsy models in rats.Methods: Forty-nine adult male Wistar rats were used in this study. The rats were divided into 7 groups as; sham (S), control (penicillin, CONT), diazepam (DZM), 10 mg/kg TQ (TQ10), 50 mg/kg TQ (TQ50), 10 mg/kg TQ+DZM (TQ10+DZM) and 50 mg/kg TQ+DZM (TQ50+DZM). TQ was administered intraperitoneally for 21 days. Epileptiform activity (EA) was initiated by intracortical administration of penicillin. Electrocorticographic (ECoG) data obtained from the recordings were analyzed. The latency, frequency, and amplitude of EA waves were analyzed statistically.Results: There was no EA in the sham group. However, it was observed that the first spike-wave latency increased significantly in TQ10 and TQ50 groups compared to the CONT group. Except for some time periods, there was no significant difference between the groups according to spike-wave frequency, and spike-wave amplitude. Conclusion: It was observed that the application of chronic thymoquinone on the experimental penicillin-induced EA model in rats did not affect the frequency and amplitude of spike-wave representing epileptic seizures. However, TQ was found to prolong the latency of the first EA.
PubDate: Fri, 20 Jan 2023 00:00:00 +030
- Fasting plasma glucose and body mass index as predictors of neoadjuvant
chemotherapy response in breast cancer
Authors: Özgecan DÜLGAR; Seval AY, Mahmut GÜMÜŞ
Abstract: Aim: Obesity is a well-known modifiable risk factor for breast cancer. Impaired fasting glucose is a component of metabolic syndrome and a significant risk for diabetes. We aimed to research the effect of these two major components of metabolic syndrome on neoadjuvant chemotherapy (NAC) response in breast cancer.Methods: We conducted 161 patients who had received NAC from January 2016 to January 2022. Fasting plasma glucose levels were measured at least two times and BMI was recorded before starting NAC. Impaired fasting glucose is defined as plasma glucose levels of 100 to 125 mg per dL. Analyses were compared into two groups according to FPG levels below or above 100 mg/dl and according to BMI obese (BMI30≥ kg/m2), or non-obese (BMI <30 kg/m2). The pathologic response was evaluated, and patients were divided into five groups according to the Miller-Payne grading system classified from grade V to I, complete pathologic response, loss of more than 90% of tumor cells, reduced 30% and 90% of tumor cells, lost less than 30% of tumor cells, and had no reduction in cellularity and no change malignant cells respectivelyResults: In the pathologic responses, 70.8% of patients with impaired fasting glucose levels were grade 1 non-reduction with NAC. Disease free-survival was shorter in the group that had impaired fasting glucose than in the group that had normal fasting plasma glucose (FPG) (p=0.031). In univariate analysis clinical stage 3 (p <0.001), postmenopausal status (p=0.037), human epidermal growth factor receptor 2 (HER-2) negativity (p<0.001), estrogen receptor (ER) positivity (p <0.001), progesterone receptor (PR) positivity (p <0.001) rate were higher in grade 1 unresponsive patients compared to patients with pathological response grade 2, grade 3 and grade 4. In multivariate analysis showed that fasting plasma glucose, clinical stage, HER-2 status, and ER status were independent predictor factors for pathological complete response (pCR). BMI had no impact on pCR. Our trial showed that the ratio of pCR in patients with impaired fasting glucose was 2.5 times lower than that in patients who had normal FPG levels [HR: 2.5, 95%CI 1.08–5.92, p = 0.03].Conclusion: Fasting plasma glucose significantly impacted both pCR and recurrence.
PubDate: Fri, 20 Jan 2023 00:00:00 +030
- Effects of creatine monohydrate supplementation in renal ischemia and
reperfusion injury
Authors: Fatma HELVACIOĞLU; Tayfun GÖKTAŞ, Hande Ozge ALTUNKAYNAK-CAMCA, Tuğçe ŞİRİNOĞLU
Abstract: Aim: Ischemia and reperfusion injury, can occur during kidney transplantations surgery, showing their effects by disrupting cellular energy metabolism and increasing oxidative stress. Creatine monohydrate, a popular sport supplement, is an endogenous compound. It is known that it reduces oxidative stress through effecting the energy metabolism of cells and has an antioxidant effect. It was aimed to evaluate the possible effect of creatine monohydrate against the increased oxidative stress and structural damage mediated by experimentally induced renal ischemia-reperfusion injury in this study.Methods: Twenty-four male Sprague Dawley (270-380 gr) rats were used in the study. Rats were randomly divided into four groups: Group-1: Control group, Group-2: Ischemia/Reperfusion group, Group-3: Ischemia / Reperfusion+ Creatine monohydrate (2g/kg/day), Group-4: Creatine monohydrate (2g/kg/day). After anesthesia, a midline abdominal incision was performed in the related groups and renal ischemia was induced by clamping left renal artery during 45 min. At the end of ischemia the non-traumatic clamp was removed and kidney reperfusion was noted as return of blush color. Afterward, abdominal posterior wall was closed. Creatine monohydrate (2 g/kg/day) was dissolved in distilled water and given to the rats with oral gavage in Group-3 and Group-4 for 3 days After 72 hours of reperfusion, cardiac blood and left kidney tissues were taken under general anesthesia and they were sacrificed. Kidney tissues were evaluated by light and electron microscopy. Total antioxidant and oxidant stress parameters were also measured in the plasma samples. Results: In the ischemia and reperfusion model, significant erythrocyte stasis was detected in the glomerular capillaries at ultrastructural level. In addition, it was observed that the integrity of the glomerular endothelial cells and podocytes could not be preserved, while the tubule lumen was occluded as a result of the swelling of epithelial cells. The statistically significant increase in the total antioxidant level in the creatine administered groups was interpreted as an indicator of the positive progress of the remodeling process.Conclusion: As a result, it was observed that creatine monohydrate supplementation did not show a significant beneficial effect a structural level, since the circulation could not be fully restored due to erythrocyte stasis caused by the procedure.
PubDate: Fri, 20 Jan 2023 00:00:00 +030
- The frequency of osteoporosis in the thoracic surgery patient population:
An opportunity assessment from thorax computed tomography scans
Authors: Mahmut SUBAŞI; Abdulkadir EREN
Abstract: Aim: To investigate the frequency of osteoporosis in thoracic surgery patients and highlight the clinical significance for physicians.Methods: Thoracic computed tomographies (CT) of 306 patients were examined for medullary density of the T12 vertebra. Men and women, as well as those under 70 and over 70, were compared in terms of Hounsfield units (HU). To evaluate the diagnostic performance of the age parameter in predicting osteoporosis, receiver operating characteristic (ROC) analysis, and logistic regression analysis were used. The rib cortical defects identified in this study group and their causes were explained.Results: HUs of 51 subjects (or 16.7%) were less than 110 (osteoporosis); 177 people (57.8%) were higher than 160 (normal). HU values ranged from 111 to 159 (borderline) for 78 individuals (25.5%). There was no significant difference between males and females. It was discovered that the difference between the population under 70 and the population over 70 was statistically significant (p<0.001). For predicting osteoporosis, the age exhibited an area under the curve of 0.857 (CI 0.806-0.908). The threshold value was 57 for women and 55 for men. Osteoporosis was shown to be accurately predicted by age with a 95.7 percent accuracy rate (p<0.001). Six patients were determined to have rib cortical defects seen on CT scans during the evaluation for osteoporosis, and two more patients had fractures noted during surgery.Conclusion: Within the 306 patients, only 57.8% had bone density within the normal range. The age parameter is valuable with high accuracy (95%) in predicting osteoporosis. The presence of osteoporosis over the age of 57 in women and over 55 in men should be evaluated and measures should be taken to protect the bones during the operation and postoperative care.
PubDate: Fri, 20 Jan 2023 00:00:00 +030
- Is modified constraint-induced movement therapy effective in improving
motor performance in patients with hemiplegia'
Authors: Emre SAHİN; Merve AKDENİZ LEBLEBİCİER, İsmail SARACOGLU, Aysun ÖZLÜ
Abstract: Aim: To investigate the effect of modified constraint-induced movement therapy (mCIMT) on upper extremity motor recovery, performance, and functional independence in addition to conventional rehabilitation in stroke patients.Methods: The study included 40 participants, including 20 chronic stroke cases in the intervention group (IG) (64.45±9.18 years) and 20 chronic stroke cases in the control group (CG) (64.45±9.18 years) who met the selection criteria. IG received mCIMT with regular physiotherapy, while CG received only regular physiotherapy. The patients were evaluated with the Motor Activity Log-28 (MAL-28), the Functional Independence Measure (FIM), and the Fugl-Meyer Upper Extremity Scale (FMUES) before treatment, immediately after treatment (post-treatment), and at three months after treatment (follow-up).Results: The MAL-28 and FIM scores significantly increased in both groups compared with the baseline values after treatment and at the third-month follow-up (p<0.05). After treatment and at the third-month follow-up, the FMUES scores significantly increased in both groups compared with the baseline values (p<0.001).Conclusion: This study showed that mCIMT added to conventional therapy improved upper extremity motor function, performance, and functional independence in chronic stroke patients; however, mCIMT had no additional benefit to conventional therapy.
PubDate: Fri, 20 Jan 2023 00:00:00 +030
- Karhavi kolon iltihabı
Authors: Kemal HÜSEYİN
Abstract: Anadolu Kliniği, 1936; Cilt 4 Sayı 4'de yayınlanan Dr. Kemal Hüseyin'in kaleme aldığı "Karhavi kolon iltihabı" isimli yazısını içermektedir.
PubDate: Fri, 20 Jan 2023 00:00:00 +030
- The relationship of Ankle-Brachial Index with glycemic level, diabetes
complications and oxidative stress index
Authors: İhsan BOYACI
Abstract: Aim: The ankle-brachial index (ABI) is a method to screen peripheral arterial disease and evaluate cardiovascular prognosis. The aim of this study was to examine the relationship of ABI with glycemic level, biochemical parameters, micro-macrovascular complications, and oxidative stress index (OSI) in patients with type 2 diabetes (T2D) and to determine the factors that may pose a risk for ischemia.Methods: This cross-sectional retrospective study was designed with 153 participants who were divided as healthy control, prediabetes, and manifest T2D according to glycemic levels. Examination of ABI and carotid artery, and diabetic neuropathy and retinopathy as well as anthropometric measurements, OSI, and biochemical parameters were performed.Results: There was a significant difference between the groups in terms of age and duration of diabetes according to ABI levels. ABI ischemia levels and glycemic levels were also significantly different. ABI groups were meaningfully different from levels of fasting glucose, postprandial glucose, insulin resistance, creatinine, and albuminuria. Likewise, a significant difference was observed between the ABI ischemic group and macrovascular complications. There was a significant difference between macrovascular complication groups and ABI, OSI, and hemoglobin A1c (HbA1c). Carotid doppler examination showed a significant difference between the OSI and the cohort divided into 6 groups. On the other hand, there was a noteworthy alteration in HbA1c and OSI of the microvascular complication groups. Factors that may pose a risk for ischemia were determined as duration of diabetes, fasting insulin level, postprandial glucose, and insulin resistance. The overall accuracy of the model was calculated as 68.6%. Conclusion: For peripheral artery disease screening in T2D, the duration of diabetes can be taken into account rather than waiting for a certain age, and the screening can be brought forward accordingly. Duration of diabetes, fasting insulin level, postprandial glucose, and insulin resistance can be suggested as risk factors for ischemia.
PubDate: Fri, 20 Jan 2023 00:00:00 +030
- To what extent are YouTube videos reliable for corneal transplantation
information'
Authors: Seray YÖRÜKOĞLU; İbrahim Ethem AY, Hamidu Hamisi GOBEKA, Mustafa DOĞAN
Abstract: Aim: To assess the reliability of corneal transplantation information in YouTube videos.Methods: The first 100 videos that appeared on the screen after typing “cornea transplant” into YouTube’s video search engine were listed on 04.03.2022. Upload date, broadcasting time, total views, daily view rate, video source and length (seconds), and number of likes and comments made were all recorded parameters. Two ophthalmologists evaluated and scored the videos blindly and independently using the Journal of the American Medical Association (JAMA), Quality Criteria for Consumer Health Information (DISCERN), Global Quality (GQ) indices.Results: When the source of the videos was evaluated, it was determined that 10 videos were uploaded by an ophthalmologist, 35 videos included a certain episode from a television program, 14 videos were uploaded by a health institution and 22 videos were uploaded by other sources. It was observed that the duration of the videos, whose source is television programs, was significantly (p<0.05) longer. According to the DISCERN classification, 21% of the videos are “very weak”, 45.7% “poor”, 17.3% “moderate”, 13.6% “good”, 2.5% “excellent” was. There was a significant difference between DISCERN classification and video duration (p<0.01) and video likes (p=0.013). According to the sources, there was no significant difference when the DISCERN, JAMA, and GQ scores were evaluated. It has been determined that there is a high correlation between the number of likes, the number of views, the rate of viewing and the number of comments on the video (p<0.01).Conclusion: YouTube is a platform that is frequently used as a source of information in the field of health and there is a significant amount of content about corneal transplantation. It has been determined that these ingredients are very weak and of poor quality at a high rate. It should not be forgotten that most patients rely on YouTube as the only source of information, so it should be considered that the content should be of high quality, up-to-date and accurate.
PubDate: Fri, 20 Jan 2023 00:00:00 +030
- Evaluation of fracture strength of teeth with external cervical root
resorption treated with different repair materials: An in vitro study
Authors: Melike BAYRAM; Emre BAYRAM, Şeyma Nur GERÇEKCİOĞLU, Tunahan DÖKEN
Abstract: Aim: The aim of this in vitro study is to evaluate the fracture strength of teeth with external cervical root resorption treated with different repair materials (MTA Angelus, RetroMTA, Biodentin).Methods: In this study, 75 single-rooted maxillary central human teeth were used. 15 samples were separated as positive control group without any treatment. Simulated external cervical resorption defects were created in the remaining 60 specimens. In the cervical third of the buccal surface of these teeth, just below the cementoenamel junction, resorption cavities of 2 mm deep, 2 mm long and 4 mm wide were prepared using a diamond bur under water cooling. The teeth were separated into 4 groups to be treated with different repair materials (n=15). The negative control group was left empty without any material. In the other 3 groups, MTA Angelus, RetroMTA and Biodentin were prepared according to the manufacturer’s instructions and applied to the cavities. All specimens were kept in an incubator at 37°C and 95% relative humidity for 14 days and then embedded in acrylic blocks. The fracture resistance of the teeth was measured in Newtons using a universal tester. Data were analyzed with one-way ANOVA and post hoc tukey test at 5% significance level.Results: No statistically significant difference was found between the Biodentin, RetroMTA and MTA Angelus groups. The fracture strength values of the repair materials used were significantly higher than the negative control group and significantly lower than the positive control group.Conclusion: With this study, it was determined that the fracture strength of teeth with ECR decreased. However, teeth were found to be more resistant to fracture when these defects were repaired with MTA, Biodentin, and RetroMTA.
PubDate: Fri, 20 Jan 2023 00:00:00 +030
- Rapid sequence intubation experiences in the pediatric emergency
department
Authors: Raziye Merve YARADILMIŞ; İlknur BODUR, Muhammed Mustafa GÜNEYLİOĞLU, Betül ÖZTÜRK, Aytaç GÖKTUĞ, Orkun AYDIN, Ali GÜNGÖR, Can Demir KARACAN, Nilden TUYGUN
Abstract: Aim: Patient selection and management of rapid sequence intubation (RSI) application in the emergency department can be challenging for clinicians. In this study, we aimed to describe the demographic information, clinical characteristics, and medical conditions of the patients who underwent RSI in our hospital’s pediatric emergency department and to present patient management strategies.Methods: Cases between 1 month to 18 years old who underwent RSI in the emergency department between January 2021 and January 2022 were analyzed retrospectively.Results: Eleven patients; 7 girls (63,6%) and 4 boys (36,4%) were included in the study. The median age of the patients was 6(2-15) [minimum (min)-maximum (max)]. The median time from symptom onset to presentation was 120 minutes (min-max 15 minutes-2 weeks). RSI indications were trauma (n=5), intracranial mass (n=4), ventriculoperitoneal shunt dysfunction (n=1), and refractory status epilepticus (n=1). All patients had focal neurological deficits on examination. Glasgow Coma Scale median score was 8 (min-max 4-15). The first neuroimaging method was cranial tomography in ten (90.9%) patients. Intracranial hemorrhage was present in 45.4% (5 patients) of the patients. No complications were observed in any of the patients during the RSI application. One patient died due to intracranial hemorrhage and shunt dysfunction. Neurological deficits (dysarthria, gait disturbance, hemiparesis, and visual impairment) were detected in five patients during their first-month follow-up.Conclusion: This retrospective study identified critically ill children who were admitted to the emergency department with acute neurological symptoms and underwent RSI to prevent increased intracranial pressure and further brain damage.
PubDate: Fri, 20 Jan 2023 00:00:00 +030
- The treatment of different odontogenic cysts in children only using
acrylic appliance-guided decompression: A long-term clinical study
Authors: Enes ÖZKAN; Bilal ÖZMEN
Abstract: Aim: Various odontogenic cysts may rarely occur in the jawbones during childhood, including radicular cysts, dentigerous cysts, and odontogenic keratocysts. Treatment for such cysts ranges from conservative approaches to radical surgical procedures. The present study evaluates the effect of the decompression alone method for treating various odontogenic cysts in children.Methods: A retrospective cohort study was performed that included pediatric patients who applied to the pedodontics clinic between 2014 and 2016. Data such as age, gender, anatomical location, reasons for admission, histopathological diagnosis and dimensions of the cysts, and associated teeth were recorded. All odontogenic cysts were treated using the decompression method with an acrylic obturator. All patients were evaluated clinically and radiologically one, three, six, and 12 months after the operation and annually thereafter.Results: As a result of the pathological examination, it was determined that 10 of the 16 odontogenic cysts were dentigerous cysts, 5 were radicular cysts and 1 was an odontogenic keratocyst. The patients consisted of 4 girls and 12 boys, with a mean age of 108.68±21.01 months. The average duration of the decompression was 7.3±1.41 months and the average follow-up was 9.6±2,56 years. In four patients, spontaneous eruption of the impacted permanent teeth was not observed; these were erupted using orthodontic treatment. In two cases of dentigerous cysts, the impacted teeth were extracted and the cyst was enucleated. In the remaining 14 cases, the permanent teeth erupted (spontaneous+orthodontic guided) successfully (87.5%), and the cysts healed completely after decompression treatment. Conclusion: To avoid developmental problems, conservative procedures should be preferred for the treatment of odontogenic cysts in children. Decompression therapy using an acrylic obturator is an effective treatment for odontogenic cysts in pediatric patients; this approach protects and maintains permanent teeth. However, new clinical studies with larger sample sizes are needed to support these results.
PubDate: Fri, 20 Jan 2023 00:00:00 +030
- An investigation of the opinions and preferences of orthodontists in
Turkey regarding the use of clear aligners in orthodontic treatment:
Original article
Authors: Tugba HALİLOGLU OZKAN; Derya DURSUN
Abstract: Aim: To evaluate orthodontists’ perspectives on clear aligner treatment in Turkey.Methods: A novel web-based survey consisting of 14 questions was developed and sent to 2027 members of the Turkish Orthodontic Society via e-mail to evaluate the reasons for why or why not they prefer clear aligners, their opinions about different brands in the market and their perspective on the future of this treatment modality. The association between demographic data and multiple choice questions was examined using Kruskal Wallis and Mann-Whitney U tests. The association between Likert-type questions and practice characteristics was analyzed using a one-way analysis of variance (ANOVA) and Turkey’s post hoc tests.Results: 62.7% of the 218 respondents currently treat their patients using clear aligners and 76.7% of them prefer Invisalign (Align Technology, California, USA), a clear aligner brand. The main reasons given by orthodontists to use clear aligners were ‘not to lag behind in technology’ and ‘to have prestige in the community’. The majority of participants (83.8%) treat fewer patients with clear aligners than with fixed appliances. 70% of the surveyed orthodontists do not believe that treatment with clear aligners will completely replace treatments with fixed appliances in the near future. 28.6% of the participants stated that they do not intend to use clear aligner treatment in at least the next 1-2 years due to ‘low financial income’ and ‘complexity of clear aligner treatments.Conclusion: The majority of the surveyed orthodontists currently use clear aligners in their practice, not because they believe clear aligners are more effective or more comfortable than braces or because they are more profitable, but rather to have prestige in the community and not to lag behind in technology. Therefore, it seems that fixed appliance treatment will maintain its place in orthodontic practice as an option for the near future.
PubDate: Fri, 20 Jan 2023 00:00:00 +030
