Publisher: University of Science and Technology, Yemen   (Total: 5 journals)   [Sort alphabetically]

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Yemeni Journal for Medical Sciences
Number of Followers: 0  

  This is an Open Access Journal Open Access journal
ISSN (Print) 2227-9601 - ISSN (Online) 2227-961X
Published by University of Science and Technology, Yemen Homepage  [5 journals]
  • Prevalence of Extended Spectrum Beta‑Lactamase in Pseudomonas aeruginosa
           isolated from patients at Sharda Hospital, Greater Noida, Western UP

    • Authors: Tarana Sarwat , Sneha Mohan , Satendra P. Singh , Dalip K. Kakru
      First page: 1
      Abstract: ABSTRACT Introduction: Pseudomonas aeruginosa is an important pathogen causing healthcare-associated infections especially in immunocompromised patients. It poses a threat to public health due to its inherent resistance to various antimicrobial agents and its ability to acquire new resistance through multiple mechanisms. Infections due to extended spectrum β-lactamase (ESBL) producing isolates of P. aeruginosa continue to be a challenge for clinicians as these result in high mortality and morbidity due to antimicrobial resistance. The aim of this study was to determine the prevalence of Cefotaximase-Munich (CTX-M) producing strains of P. aeruginosa in Sharda hospital, Greater Noida. Methods: Strains of P. aeruginosa isolated from various clinical samples were subjected to phenotypic detection for ESBL production by disc combination method. Positive strains were then subjected to polymerase chain reaction (PCR) for detection of blaCTX-M gene. Results: Out of 166 isolates of P. aeruginosa, 54 (32.53%) were phenotypically confirmed to produce ESBL. Out of these 54 isolates, 39 (72.22%) were positive for blaCTX-M gene. Multidrug resistance was found in 70 (42.17%) isolates. Imipenem was the most effective drug with a sensitivity of 64.86% whereas aztreonam was found to be least effective with sensitivity of only 36.74%. Conclusion: Current study highlights the phenotypic and molecular characterization of CTX-M gene in P.aeruginosa in our hospital set-up. With judicious use of antimicrobials and strict infection control practices, it might be possible to limit the effect of these drug destroying enzymes. Keywords: CTX-M gene, Extended spectrum beta lactamases, Hospital acquired infections, multidrug resistance, Pseudomonas aeruginosa.
      PubDate: 2022-06-14
      DOI: 10.20428/yjms.v16i1.1915
      Issue No: Vol. 16, No. 1 (2022)
  • Hepatitis B and C among Multi-Transfused Pediatric Thalassemic Patients in
           Sana'a City, Yemen: A Single-Center Retrospective Study

    • Authors: Ahmed S. Hudna, Adeeb A. Salah, Ahmed A. S. Almaqrami, Adam F. Senan, Farook A. Berman, Ibrahim M. Ali, Mohammed A. Al-Khalqi, Omar H. Al-Shoaibi, Waheeb M. Ali, Yahya A. Al-Arashani
      Pages: 7 - 13
      Abstract: Objective: To determine the prevalence of hepatitis B and C infections and their association with repeated blood transfusions among thalassemic children attending the Yemen Society for Thalassemia and Genetic Blood Disorders (YSTGBD) in Sana’a city, Yemen.
      Methods: This retrospective cross-sectional study analyzed the medical records of 195 thalassemic children aged <18 years taken who were attending the YSTGBD from January 2008 to December 2018. Data about the gender and age of the child, time of thalas- semia diagnosis, frequency of monthly blood transfusions, hepatitis B virus (HBV) vaccination status, hepatitis B infection and hepatitis C virus (HCV) seropositivity were retrieved from the records into a data collection sheet. Data were then analyzed and summarized as frequencies and proportions. The association between the independent variables and infection with hepatitis B and/or hepatitis C was tested using the chi-square test.
      Results: The majority of thalassemic children attending the YSTGBD were males (58.5%), aged 8 years or older (81.0%), diag- nosed with thalassemia at 6 months of age or older (71.8%, were receiving ≤500 ml of transfused blood per month (88.7%) and had been vaccinated against HBV (72.8%). Regarding the serostatus for viral hepatitis, 15.4% (30/195) of children were seroposi- tive for the antibodies against HCV, 13.3% (26/195) were infected with hepatitis B as confirmed by HBsAg seropositivity, and 4.1% (8/195) were concomitantly seropositive for HBsAg and anti-HCV. Not getting vaccinated against HBV was significantly associated with infection with HBV (P <0.001), where 45.3% of unvaccinated children were seropositive compared to 1.4% of vaccinated children. In contrast, gender, age, age at thalassemia diagnosis and the quantity of monthly transfused blood were not significantly associated with infection with hepatitis B, anti-HCV seropositivity, or concomitant seropositivity for HBsAg and anti- HCV among thalassemic children.
      Conclusions: Viral hepatitis is a major problem for thalassemic children seeking healthcare in institutions of concern in Yemen, but it is rather difficult to assess the status of hepatitis C infection because of the lack of confirmatory tests. On the other hand, vaccination against HBV is significantly associated with a lower prevalence of hepatitis B among thalassemic children, highlighting the need for vaccinating all thalassemic children before enrollment in specialized centers of care. Thalassemic children should be screened for blood-borne viruses, including hepatitis viruses, before the establishment of regular blood transfusions.
      PubDate: 2022-12-27
      DOI: 10.20428/yjms.v16i1.2008
      Issue No: Vol. 16, No. 1 (2022)
  • Nasal Carriage of Staphylococcus aureus among staff and Students of
           University of Sciences and Technology, Aden-Yemen

    • Authors: Mohammed A. A. Al-Baghdadi
      Pages: 14 - 22
      Abstract: Background: Colonization of human nose by Staphylococcus aureus represent up to 30% of the human population. S. aureus must defeats the host’s defense mechanisms in order to colonize the nasal epithelial cells of human. Some factors such as bacterial interaction in human nose can prevent such colonization.
      Aim: The aim of current study was to determine the prevalence of nasal colonization by S. aureus among the staff and students of University of Science & Technology, Aden; as well as the associated risk factors for nasal carriage.
      Subjects and Methods: The type of study was an institution-based cross-sectional study which performed during the period from January to March 2020. The total samples were 1030 nasal swabs obtained from all the staff and students, the specimens were transported to the laboratory and the swabs were processed within 4 hrs. of collection.
      Results: The mean age of the study sample was 21.4 (±5.8 SD). The prevalence S. aureus isolated from nasal carriages was 31%. S. aureus nasal carriage show high frequency among age group 27-36 (32.4%) followed by those at age of 17-26 years (31%), however, there was no a statistically significant association in relation to the age groups (P=0.9). Regarding gender, it was considered a risk factor. S. aureus more common in male than female. The pattern of sleep, smoking, and frequent touching the nose were statistically associated with the S. aureus nasal colonization. Those who had nasal sensitivity was considered risk factor (RR=1.3) but with non-significant association with S. aureus nasal colonization (P=0.4).
      Conclusion: The current study revealed that community acquired was the potential colonizers of S. aureus. With the prevalence of 31% of the study sample, age, gender, and smoking, and other were potential risks. Regular screening of carriers is required for prevention of community acquired infections.
      PubDate: 2022-12-27
      DOI: 10.20428/yjms.v16i1.2009
      Issue No: Vol. 16, No. 1 (2022)
  • Graftless Maxillary Sinus Lifting with Simultaneous Dental Implant
           placement in Extraction Socket and Edentulous Ridge: A prospective
           Clinical Study

    • Authors: Mohammed Mansoor Albadani, Mohammed Ali Al-wesabi, Sadam Ahmed Elayah
      Pages: 23 - 33
      Abstract: Aim: The present study aimed to evaluate the amount of bone formed after graftless maxillary sinus lifting procedure in edentulous ridges compared to newly extracted teeth sites when a simultaneous dental implant planned to be inserted.
      Subjects and methods: Twenty patients who needed dental implant in the posterior maxilla having a reduced vertical bone height were divided into two groups, fresh extraction socket group (10 cases) and patients with edentulous ridges at the site of indicated implant. All implants were from the same company with the same diameter and length. Dental Cone Beam Computed Tomography (CBCT) examination was performed to assess the bone gain height radiographically at 6 months after surgery.
      Results: The mean height of sinus elevation in extraction socket group was statistically significant higher than edentulous ridge group (4.02±0.84 and 2.63±1.56; respectively, P=0.023). Percentage change in the edentulous ridge group was (56.79±40.33), which is higher than that of extraction socket group (29.79±23.68) yet the difference was not significant (P=0.085).
      Conclusion: Dental implants at the site of pneumatized bone with simultaneous sinus lifting without bone graft showed a good and successful outcome in regard to bone gain and increased bone height with the fresh extraction socket cases.
      PubDate: 2022-12-27
      DOI: 10.20428/yjms.v16i1.2010
      Issue No: Vol. 16, No. 1 (2022)
  • Development of Nanoliposome of Labisia pumila Standardized Extract

    • Authors: Mohammed Ali Ahmed Saeed, Abdul Hakeem Memon, Armaghan Shafaei, Moh'd Shahrul Ridzuan Hamil, Amirin Sadikun, Zhari Ismail
      Pages: 34 - 42
      Abstract: Background: Labisia pumila Labisia pumila Labisia pumila Labisia pumila Labisia pumila Labisia pumila Labisia pumila Labisia pumila Labisia pumila has been used traditionally for the treatment of several ailments such as gonorrhoea, dysmenorrhoea
      and as tonics for females females.
      Aims: To investigate the standardization procedure of Labisia pumila Labisia pumila Labisia pumila Labisia pumila Labisia pumila Labisia pumila Labisia pumila Labisia pumila Labisia pumila extract (LPE) and evaluation of its nanoliposomes.
      Labisia pumila Labisia pumila Labisia pumila Labisia pumila Labisia pumila Labisia pumila Labisia pumila Labisia pumila Labisia pumila Labisia pumila extract was standardized by high performance liquid chromatography (HPLC), and gallic acid, caffeic
      acid, rutin and 2,4 2,4-Di -tert tert-butylphenol were quantified in the extract. Then, the standardized extract was prepared as nanoliposome
      using soy bean phospholipid by the film method and after that was characterized by zetasizer, zeta potential, UV -Vis
      spectrophotometer and FTIR techniques techniques.
      For the standardization, the mean percentage recovery values of the concentration studied were 98.49 98.49±1.43, 97.01 97.01±2.04,
      97.7097.70±1.55 and 99.43 99.43±3.04 % for gallic acid, caffeic acid, rutin and 2,42,4-Di -tert tert-butylphenol, respectively. The accuracy values were
      between 95.06 and 104.86% for the marker compounds, while the corresponding precision values were betwee n 0.09 and 5.18% for
      withinwithin-day and between between-day analysis, respectively. The average particle size for LLP was 174.20±4.58 nm with zeta potential of
      particles surface charge from −43.40 to − 44.40 mV. The polydispersity index was 0.19±0.02 and the morpholo gy and presence of
      liposomes were further confirmed by transmission electron microscopy which revealed the presence of spherical liposomes of < 200
      HPLC method for the simultaneous determination of selected marker compounds has been develop ed; the method was
      reliable, repeatable and reproducible. The method was successfully applied in standardization of LPE. LPE was successfully pr epared
      as nanoliposome using soybean phospholipid.
      PubDate: 2022-12-27
      DOI: 10.20428/yjms.v16i1.2011
      Issue No: Vol. 16, No. 1 (2022)
School of Mathematical and Computer Sciences
Heriot-Watt University
Edinburgh, EH14 4AS, UK
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