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Journal of the ASEAN Federation of Endocrine Societies
Journal Prestige (SJR): 0.136
Number of Followers: 0  

  This is an Open Access Journal Open Access journal
ISSN (Print) 0857-1074 - ISSN (Online) 2308-118X
Published by ASEAN Federation of Endocrine Societies Homepage  [1 journal]
  • A Comparison of Statin Treatment Algorithms based on the ACC/AHA and
           Philippine Guidelines for Primary Prevention of Dyslipidemia in
           Statin-Naive Filipino Patients

    • Authors: Bayani Pocholo Maglinte, Alex Junia, Jeremyjones Robles
      Abstract: Objectives. This cross-sectional study evaluates the degree of agreement between the 2018 American College of Cardiology/American Heart Association (ACC/AHA2018) and 2020 Philippine guideline (PG2020) treatment algorithms for the primary prevention of dyslipidemia among Filipinos. Methodology. This review included 159 charts of tatin-naive Filipinos who are 45-79 years old. Using risk profile and lipid measurements, statin treatment recommendation was determined through the PG2020 algorithm and ACC/AHA-ASCVD Risk Estimator Plus web application. The degree of agreement was measured by Cohen’s kappa statistic with the two algorithms as independent raters. Results. A total of 159 patients were included in the final analysis. There was a slight agreement with a kappa coefficient of 0.209 or 4.4% (95% CI 0.078-0.340, p=0.003). Statin treatment was recommended in 69 out of 159 patients (43.4%) by the PG2020 overlapping with ACC/AHA2018 in 56 cases (81.2%). On the other hand, 109 cases (68.6%) were recommended for statin treatment by ACC/AHA2018 overlapping with PG2020 in only 51.4%. Conclusions. The low degree of agreement between the two treatment algorithms highlights the key demographic and ethnic variations in dyslipidemia management necessitating outcome-based studies to translate these differences. Overestimation of ASCVD risk calculation in the ACC/AHA2018 and consideration of important, unique risk factors among Filipinos favors the applicability of the Philippine guideline.
      PubDate: 2022-09-14
  • Glycaemic Changes among Children and Adolescents with Type 1 Diabetes
           Mellitus Before and During Ramadan Fasting using Continuous Glucose

    • Authors: Sze Teik Teoh, Suhaimi Hussain, Janet Yeow Hua Hong
      Abstract: Objectives . This study described and compared glycaemic changes with the use of the following Continuous Glucose Monitoring (CGM) metrics: time in range, time in hyperglycaemia and time in hypoglycaemia from retrospective CGM data among children and adolescents with Type 1 Diabetes Mellitus (T1DM), before and during Ramadan to better understand the impact of fasting during this season. Methodology. This study was conducted in 2 tertiary centres: Hospital Putrajaya (HPJ) and Hospital Universiti Sains Malaysia (HUSM) from February to May 2020. Muslim T1DM patients between ages 8 to18 who intended to fast during Ramadan were given Ramadan-focused education. CGM iPro2® (Medtronic) was used before and during Ramadan, complemented by finger-prick glucose monitoring or self-monitoring of blood glucose (SMBG). Results. Of the 32 patients, only 24 (12 female) were analysed. Mean age was 13.6 ± 3.1 years old, mean HbAlc was 9.6 ± 1.9% and mean duration of illness was 5.4 ± 3.4 years. Majority (91.7%) were on multiple dose injections (MDI) while only 8.3% were on continuous subcutaneous insulin infusion (CSII). All fasted in Ramadan without acute complications. Retrospective CGM analysis revealed similar results in time in range (TIR), time in hyperglycaemia and time in hypoglycaemia before and during Ramadan, indicating no increased hypoglycaemic or hyperglycaemic events related to fasting. Glycaemic variability before Ramadan as measured by the LBGI, HBGI and MAG, were similar to values during Ramadan. Conclusion. Ramadan fasting among T1DM children and adolescents, by itself, is not associated with short-term glycaemic deterioration. T1DM youths can fast safely in Ramadan with the provision of focused education and regular SMBG.
      PubDate: 2022-09-08
  • An Atypical Presentation of Primary Hyperparathyroidism with Multiple
           Spontaneous Tendon Ruptures

    • Authors: Jielin Yew, Shui Boon Soh
      Abstract: Primary hyperparathyroidism (PHPT) is a common endocrine condition, increasingly presenting asymptomatically and detected on routine laboratory examination in developed countries. Multiple spontaneous tendon ruptures as the initial presentation of PHPT is extremely rare. We present the case of a 28-year-old male diagnosed with severe hypercalcemia secondary to PHPT after presenting with complications of multiple spontaneous tendon ruptures,and discuss the management issues in PHPT for this patient.
      PubDate: 2022-09-08
  • Use of Combination of Oral Levothyroxine and Liothyronine in Severe
           Hypothyroidism with Massive Pericardial Effusion

    • Authors: Poh Shean Wong, Sue Wen Lim, Chin Voon Tong, Masni Mohamad, Zanariah Hussein
      Abstract: Thyroid hormone plays an important role in cardiovascular function. Pericardial effusions are commonly seen in cases of severe hypothyroidism. However, large to massive pericardial effusions with cardiac tamponade are exceptionally rare. Herein, we present two cases of severe hypothyroidism with massive pericardial effusion. Our first case demonstrates that a patient with large pericardial effusion can be managed conservatively with aggressive thyroid hormone replacement therapy. In our second case, pericardiocentesis was performed in addition to thyroid hormone replacement therapy as the underlying aetiology of effusion could not be reasonably limited to hypothyroidism. These two cases served to highlight and demonstrate rapid normalisation of thyroid function test by using aggressive oral thyroid hormone replacement therapy using liothyronine, in combination with levothyroxine, which led to resolution of pericardial effusion and prevent its re-accumulation.
      PubDate: 2022-09-05
  • Genetic Variants Associated with Poor Responsiveness to Sulfonylureas in
           Filipinos with Type 2 Diabetes Mellitus

    • Authors: Elizabeth Paz-Pacheco, Jose Nevado Jr., Eva Maria Cutiongco-de la Paz, Gabriel Jasul Jr., Aimee Yvonne Criselle Aman, Elizabeth Laurize Alejandro - Ribaya, Mark David Francisco, Ma. Luz Vicenta Guanzon, May Uyking - Naranjo, Ma. Cecilia Añonuevo - Cruz, Maria Patricia Deanna Maningat, Cristina Jaring, Paulette Nacpil - Dominguez, Aniza Pala-Mohamad, Abigail Uy-Canto, John Paul Quisumbing, Annabelle Marie Lat, Diane Carla Bernardo, Noemie Marie Mansibang, Vincent Sean Ribaya, Karell Jo Angelique Calpito, Julius Patrick Ferrer, Jessica Biwang, Jodelyn Melegrito, Christian Deo Deguit, Carlos Emmanuel Panerio
      Abstract: Introduction. Sulfonylureas (SUs) are commonly used drugs for type 2 diabetes mellitus (T2DM) in the Philippines. This
      study aimed to associate genetic variants with poor response to gliclazide and glimepiride among Filipinos. Methodology. Two independent, dichotomous longitudinal substudies enrolled 139 and 113 participants in the gliclazide
      and glimepiride substudies, respectively. DNA from blood samples underwent customized genotyping for candidate
      genes using microarray. Allelic and genotypic features and clinical associations were determined using exact statistical
      methods. Results. Three months after sulfonylurea monotherapy, 18 (13%) were found to be poorly responsive to gliclazide, while
      7 (6%) had poor response to glimepiride. Seven genetic variants were nominally associated (p<0.05) with poor gliclazide
      response, while three variants were nominally associated with poor glimepiride response. For gliclazide response, 3
      carboxypeptidase-associated variants (rs319952 and rs393994 of AGBL4 and rs2229437 of PRCP) had the highest
      genotypic association; other variants include rs9806699, rs7119, rs6465084 and rs1234315. For glimepiride response,
      2 variants were nominally associated: CLCN6-NPPA-MTHFR gene cluster – rs5063 and rs17367504 – and rs2299267
      from the PON2 loci. Conclusion. Genetic variants were found to have a nominal association with sulfonylurea response among Filipinos.
      These findings can guide for future study directions on pharmacotherapeutic applications for sulfonylurea treatment in
      this population.
      PubDate: 2022-09-01
  • Comparison of Maternal and Neonatal Outcomes among High-Risk Filipino
           Women with Gestational Diabetes Diagnosed Before and After 24 weeks of

    • Authors: Kriselle Rae Dy, Christy Yao
      Abstract: Objectives. This study determined the prevalence, clinical characteristics and pregnancy outcomes of high-risk women diagnosed with gestational diabetes mellitus (GDM) before and after 24 weeks of gestation. Methodology. This retrospective study included all singleton deliveries with GDM at the Pasig City General Hospital from January 2018 to December 2019. Subjects were grouped into those who were diagnosed with GDM before 24 weeks of gestation (<24 weeks, n=61) and thereafter (≥24 weeks, n=219). Outcomes examined were preeclampsia, cesarean delivery, preterm birth, macrosomia, large-for-gestational age, small-for-gestational age, neonatal hypoglycemia, neonatal ICU admission, congenital malformations and perinatal mortality. Results. The group diagnosed with GDM before 24 weeks was significantly older (33.0 ± 5.7 years versus 29.4 ± 5.9 years, p<0.001), had higher 2-hour 75 g oral glucose tolerance test (OGTT) results (158.2 ± 20.0 mg/dL versus 150.0 ± 23.7 mg/dL, p=0.014), and had more pregnancies with preeclampsia (23.0% versus 9.6%, p=0.005). Conclusion. High-risk women diagnosed with GDM before 24 weeks of gestation had a higher incidence of preeclampsia compared with high-risk women diagnosed with GDM after 24 weeks of gestation.
      PubDate: 2022-08-27
  • Risk Factors for Inpatient Hypoglycemia in a Tertiary Care Hospital in

    • Authors: Chici Pratiwi, Martin Rumende, Ida Ayu Made Kshanti , Pradana Soewondo
      Abstract: Introduction. Hypoglycemia is an important and harmful complication that often occurs in inpatient and outpatient settings. This study aims to assess the incidence of inpatient hypoglycemia and its related factors. We also assessed mortality and length of hospital stay. Methodology. We performed a retrospective cohort study among patients with type 2 diabetes mellitus admitted to a tertiary hospital in Indonesia. Using multivariate regression, we analyzed age, sex, body mass index, comorbidities, history of hypoglycemia, hyperglycemia treatment administered, nutritional intake, and medical instruction as the related risk factors for inpatient hypoglycemia. Results. From 475 subjects, 80 (16.8%) had inpatient hypoglycemia, of which, 7.4% experienced severe hypoglycemia. We found that patients with a history of hypoglycemia (RR: 4.6; 95% CI: 2.8-7.6), insulin and/or sulfonylurea treatment (RR 6.4; 95% CI: 1.6-26.5), and inadequate nutritional intake (RR 2.6; 95% CI: 1.5-4.3) were more likely to have hypoglycemic events compared to those who did not. The length of hospital stay for patients in the hypoglycemic group is significantly longer than those in the non-hypoglycemic group (13 vs 7 days, p<0.001), but their mortality rates did not differ (16% vs 10.9%, p=0.18). Conclusion. Inpatient hypoglycemia may be affected by a history of hypoglycemia and inadequate nutritional intake. Patients who had inpatient hypoglycemia tend to have a longer median length of hospital stay.
      PubDate: 2022-08-24
  • Efficacy and Safety of Semaglutide for Weight Loss in Obesity without

    • Authors: Hanna Clementine Tan, Oliver Allan Dampil, Maricar Mae Marquez
      Abstract: Background. The weight loss benefit of semaglutide in patients with diabetes is well-documented, but its clinical utility in treating obesity among patients without diabetes is less described. We therefore assessed the efficacy and safety of subcutaneous semaglutide as treatment for obesity in patients without diabetes. Methodology. A comprehensive search of PubMed/MEDLINE, Cochrane and Google scholar was performed to identify trials on the efficacy and safety of subcutaneous semaglutide on patients with obesity without diabetes. Primary outcome was expressed as percent mean weight difference. Secondary outcomes including risk for gastrointestinal adverse events, discontinuation of treatment and serious adverse events were expressed as risk ratios. These were calculated using the random effects model. Results. The study included 4 randomized controlled trials having a total of 3,613 individuals with obesity without diabetes. The mean difference for weight reduction was -11.85%, favoring semaglutide [95% confidence interval (CI) (-12.81,-10.90), p<0.00001]. Secondary outcomes showed that the risk of developing gastrointestinal adverse events was 1.59 times more likely with semaglutide (RR 1.59, 95%CI [1.34, 1.88], p<0.00001). Risk for discontinuation due to adverse events was twice as likely in the semaglutide group (RR 2.19, 95%CI [1.36,3.55], p=0.001) and the risk for serious adverse events was 1.6 times more likely for semaglutide (RR1.60, 95% CI [1.24, 2.07], p=0.0003). Serious events were mostly of gastrointestinal and hepatobiliary disorders such as acute pancreatitis and cholelithiasis. Conclusion. Among individuals with obesity without type 2 diabetes, subcutaneous semaglutide is effective for weight loss with an 11.85% reduction from baseline compared to placebo. This supports the use of semaglutide for weight management in obesity. However, risk of gastrointestinal adverse events, discontinuation of treatment and serious adverse events were higher in the semaglutide group versus placebo.
      PubDate: 2022-08-22
  • Prevalence of Diabetes among Community-living Older Persons in the

    • Authors: Maria Stella Giron, Shelley Ann de la Vega
      Abstract: Objective. To estimate the prevalence of diabetes among Filipino older persons living in the community. Methodology. A cross-sectional analysis was done on a random sample of persons ages 60 years and older from the Focused Interventions for Frail Older Adults Research and Development Program (2018-2019). A diagnosis of diabetes was established by self-reported physician’s diagnosis or if the person was on any antihyperglycemic drugs. Results. The prevalence of self-reported diabetes was 20.5%, with no difference in age, sex, education, or body mass index between older persons with and without diabetes. The presence of 2 or more comorbidities was significantly more common among older persons with diabetes (p<0.001). Visual impairment (p<0.01), hypertension (p<0.001) and hyperlipidemia (p <0.001) were more frequent among those with diabetes. Conclusion. Diabetes is prevalent among community-living older Filipinos. Therefore, effective public health measures for diabetes prevention and management are needed for the ever-growing older population, who are at the highest risk for morbidity and mortality.
      PubDate: 2022-08-22
  • Severe Pericardial Effusion due to Autoimmune Hypothyroidism with
           Levothyroxine Withdrawal and Systemic Lupus Erythematosus

    • Authors: Sylvernon Israel, Katherine Ann Tan, Ma. Felisse Carmen Gomez, Florence Rochelle Gan, Jean Uy-Ho
      Abstract: The presence of autoantibodies is a common link between autoimmune hypothyroidism (AH) and Systemic Lupus Erythematosus (SLE). The coexistence of AH (Hashimoto’s Thyroiditis) and SLE is common; however, massive pericardial effusion (PEEF) with signs of tamponade is extremely rare and only a few cases have been reported in literature. We present a case of a 54-year-old female who came in with progressive dyspnea who was found out to have massive PEEF from overt AH and concurrent SLE, which was successfully managed medically. This gave us valuable insight that massive pericardial effusion occurring in overt hypothyroidism may be secondarily caused by other co-existing disease entities such as SLE. The importance of the correct diagnosis cannot be overemphasized, as this largely contributed to the successful management of this case.
      PubDate: 2022-08-17
  • Detection of Hemostasis Abnormalities in Type 2 Diabetes Mellitus using

    • Authors: Putu Moda Arsana, Novi Khila Firani, Siti Fatonah, Affa Kiysa Waafi, Adinda Dian Novitasari
      Abstract: Introduction. Type 2 DM (T2DM) is associated with inflammation and vascular dysfunction which impact hemostasis. Thromboelastography (TEG) as a hemostasis assessment method, is not routinely applied in T2DM. Methodology. A cross-sectional study was conducted among T2DM patients attending the Endocrinology Clinic of Saiful Anwar Hospital, Indonesia. Glycemic profiles were determined using fasting plasma glucose (FPG), 2-hour postprandial plasma glucose (2hPPG), and glycosylated hemoglobin (HbA1c). Therapy for T2DM was classified into insulin and non-insulin regimens. The primary and secondary hemostasis profile were examined using TEG and was classified as hypo- hyper- and normo- Result. A total of 57 T2DM patients were included. Kruskal-Wallis test did not reveal a significant association between glycemic profiles and groups of hemostasis. However, the median HbA1c was higher in the hypercoagulable group of primary hemostasis and fibrinolysis. The median FPG and 2hPPG were higher in the normo-coagulable group of secondary hemostasis. Logistic regression did not indicate a significant association between type of therapy for diabetes and hemostasis profile. Conclusion. This study did not find significant associations between glycemic levels and type of DM therapy with hemostasis profiles using the TEG method in patients with T2DM.
      PubDate: 2022-08-12
  • The Effect of Glucocorticoids on TAF1 Gene Transcription in X-linked
           Dystonia Parkinsonism

    • Authors: Sam Ezrael Dela Cruz, Pia Bagamasbad
      Abstract: Objective. X-linked Dystonia Parkinsonism (XDP) is associated with a SINE-VNTR- Alu (SVA) retrotransposon insertion in an intron of the TAF1 gene that alters gene transcription and splicing. In this study, we determined if the SVA insertion introduces glucocorticoid (GC)-responsive cis-regulatory elements that may contribute to dysregulated TAF1 transcription and XDP disease progression. Methodology. We performed in silico analysis to identify potential GC receptor (GR) binding sites within the XDP-SVA. We also conducted promoter-reporter assays on HeLa and HEK293T cells to assess the intrinsic promoter activity of three XDP-SVA variants representing different hexameric repeat lengths associated with differences in disease onset. We treated XDP fibroblast cell models with GR agonist (CORT) or antagonist (RU486), then subjected TAF1 and the XDP-associated aberrant transcript, TAF1-32i to gene expression analysis. Results. A transcription factor binding site search revealed three binding sites for GR within the XDP-SVA—two within the SINE region and one in the Alu region. Promoter-reporter assays showed induction of XDP-SVA promoter activity upon CORT treatment that was dependent on the cell line and XDP-SVA hexamer repeat length. Gene expression analysis showed that baseline TAF1 levels differed between control and patient fibroblast cell lines, and treatment with CORT led to an increasing trend in the expression of the aberrant TAF1-32i transcript but did not reach statistical significance. Treatment with RU486 increased TAF1 mRNA expression only in the control cell lines. Conclusion. Using reporter assays, the XDP-SVA was shown to exhibit CORT-dependent transcriptional activation. Gene expression analysis also showed that GC signaling may influence TAF1 and TAF1-32i expression, possibly through interaction with the XDP-SVA. Our data provide a potential link between stress and XDP progression.
      PubDate: 2022-08-07
  • Bisphenol S Increases Cell Number and Stimulates Migration of Endometrial
           Epithelial Cells

    • Authors: Kimberly Benjamin, Cielo Mae Marquez, Madeleine Morta, Emmanuel Marc Reyes, Lemnuel Aragones, Michael Velarde
      Abstract: Objective. To determine whether bisphenol S (BPS), a common substitute for bisphenol A (BPA), induces cell proliferation and migration in human endometrial epithelial cells (Ishikawa) and adult mouse uterine tissues. Methodology. Human endometrial Ishikawa cells were exposed to low doses of BPS (1 nM and 100 nM) for 72 hours. Cell proliferation was assessed through the viability assays MTT and CellTiter-Glo®. Wound healing assays were also used to evaluate the migration potential of the cell line. The expression of genes related to proliferation and migration was also determined. Similarly, adult mice were exposed to BPS at a dose of 30 mg/kg body weight/day for 21 days, after which, the uterus was sent for histopathologic assessment. Results. BPS increased cell number and stimulated migration in Ishikawa cells, in association with the upregulation of estrogen receptor beta (ESR2) and vimentin (VIM). In addition, mice exposed to BPS showed a significantly higher mean number of endometrial glands within the endometrium. Conclusion. Overall, in vitro and in vivo results obtained in this study showed that BPS could significantly promote endometrial epithelial cell proliferation and migration, a phenotype also observed with BPA exposure. Hence, the use of BPS in BPA-free products must be reassessed, as it may pose adverse reproductive health effects to humans.
      PubDate: 2022-08-06
  • Adrenocortical Carcinoma with Cushing’s Syndrome and Extensive Tumor
           Thrombosis of the Inferior Vena Cava in a 30-year-old Filipino Female

    • Authors: Kristine Abas, Maria Honolina Gomez, Jennifer Mapanao-Gonong, Rosella Arellano
      Abstract: Adrenocortical carcinoma (ACC) is a rare and aggressive neoplasm with poor prognosis. We report a case of a 30-year-old female who presented with profound classic features of an adrenocorticotrophic hormone (ACTH)-independent Cushing’s syndrome (CS) and a large adrenal mass with massive venous tumor thrombosis of the entire inferior vena cava (IVC), left renal and adrenal veins confirmed by imaging. Adrenal biopsy histopathology and immunohistochemistry confirmed ACC. Systemic palliative chemotherapy was administered. This rare case presents a unique and atypical presentation of an extensive tumor thrombosis of IVC. With the advanced stage at diagnosis, aggressive nature and poor prognosis of the disease, there is still a need to determine viable therapeutic options for metastatic ACC associated with venous invasion.
      PubDate: 2022-08-06
  • Neonatal Outcomes of Pregnancies Complicated by Maternal Hyperthyroidism

    • Authors: Adlina Awanis Mamat , Noraida Ramli, Najib Majdi Yaacob, Suhaimi Hussain
      Abstract: Objective. This study aimed to determine the proportion, clinical characteristics, hormonal status, median time for normalization of serum thyroxine (FT4) and thyroid-stimulating hormone (TSH) and factors affecting time to thyroid function test (TFT) normalization of neonates born to mothers with maternal hyperthyroidism admitted in our institution. Methodology. This was a retrospective cohort study that included 170 newborns admitted to the Neonatal Intensive Care Unit (NICU) of Hospital Universiti Sains Malaysia (HUSM) with a history of maternal hyperthyroidism from January 2013 until December 2018. We analyzed their baseline demographic and clinical characteristics, maternal thyroid status and antibody levels. Finally, we analyzed newborn thyroid function and thyroid antibodies. Results. The proportion of neonates born to mothers with maternal hyperthyroidism was 0.8% (170 of 20198 neonates within the study period). Seven (4.1%) developed overt hyperthyroidism, while four (2.4%) had thyroid storm. The median time for thyroid function test normalization was 30 days (95% CI: 27.1 to 32.8). The median time for TFT normalization was longer among neonates of mothers with positive thyroid antibodies [46.6 days ( 39.4)] and of mothers who received anti-thyroid treatment [31.7 days (95% CI, 23.5 to 39.9)]. Conclusion. Neonates born to mothers with hyperthyroidism is uncommon. These babies were observed to have a longer time for normalization of thyroid function tests if their mothers had thyroid antibodies or received anti-thyroid treatment.
      PubDate: 2022-08-05
  • Prevalence of Bacterial Urinary Tract Infection Among Patients with Type 2
           Diabetes Mellitus on Sodium-Glucose Cotransporter-2 Inhibitors

    • Authors: Pankaj Ferwani, Aasim Maldar, Nishitkumar Shah, Phulrenu Chauhan, Manoj Chadha
      Abstract: Background. Genitourinary tract infections, mycotic as well as bacterial, as defined by clinical symptoms, are one of the common adverse effects associated with the use of sodium-glucose cotransporter-2 inhibitors (SGLT2i) in type 2 diabetes mellitus (T2DM) patients in clinical trials. However, Indian data in terms of the prevalence of culture-proven bacterial type of urinary tract infection (UTI), and the causative organism is limited. Objective. This study aimed to determine the prevalence and causative agents of bacterial UTI among patients with T2DM on SGLT2i. Methodology. This was a prospective longitudinal study involving all patients with T2DM who were prescribed with SGLT2i, uncontrolled on other oral anti-diabetic medications, from June 2019 to February 2020. Prevalence of bacterial UTI was evaluated at baseline and 12 weeks after initiation of SGLT2i. Results. A total of 80 patients were started on SGLT2i. One female patient on canagliflozin had significant asymptomatic bacteriuria and the causative agent was Acinetobacter baumannii. One male patient on dapagliflozin had symptomatic urinary tract infection with negative urine culture study. Four patients developed genital mycotic infection. Conclusion. In this real-world study, SGLT2i as a class, was well tolerated with favorable safety profile, and risk of developing significant bacteriuria and/or symptomatic UTI was minimal.
      PubDate: 2022-07-24
  • Validation of Genome-Wide Association Studies (GWAS)-Identified Type 2
           Diabetes Mellitus Risk Variants in Pakistani Pashtun Population

    • Authors: Asif Jan, Zakiullah, Fazli Khuda, Rani Akbar
      Abstract: Objective. Recent GWAS largely conducted in European populations have successfully identified multiple genetic risk
      variants associated with Type 2 Diabetes Mellitus (T2DM). However, the effects conferred by these variants in the
      Pakistani population have not yet been fully elucidated. The objective of this study was to examine European GWAS-identified T2DM risk variants in the Pakistani Pashtun population to better understand the shared genetic basis of T2DM in the European and Pakistani cohorts. Methodology. A total of 100 T2DM patients and 100 healthy volunteers of Pashtun ethnicity were enrolled in this study.
      Both groups were genotyped for 8 selected single nucleotide polymorphisms (SNPs) using the Sequenom MassARRAY®
      platform. The association between selected SNPs and T2DM was determined by using appropriate statistical tests. Results. Of the 8 studied SNPs, 5 SNPs, SLC30A8/ rs13266634 (p=0.031, OR=2.13), IGF2BP2/ rs4402960 (p=0.001,
      OR=3.01), KCNJ11/ rs5219 (p=0.042, OR=1.78), PPARG/ rs1801282 (p=0.042, OR=2.81) and TCF7L2/ rs7903146
      (p=0.00006, 3.41) had significant association with T2DM. SNP GLIS3/ rs7041847 (p=0.051, OR=2.01) showed no
      sufficient evidence of association. SNPs KCNQ1/ rs2237892 (p=0.140, OR=1.61) and HHEX/IDE/s1111875 (p=0.112,
      OR=1.31) showed opposite allelic effects and were not validated for T2DM risk in the study population. Among the studied SNPs, TCF7L2/ rs7903146 showed the most significant association. Conclusion. Our study finding indicates that selected genome-wide significant T2DM risk variants previously identified
      in European descent also increase the risk of developing T2DM in the Pakistani Pashtun population.
      PubDate: 2022-06-16
  • Factors Associated with Dietary Behaviour among Patients with Type 2
           Diabetes Mellitus in Rural Indonesia

    • Authors: Anggraini Dwi Kurnia, Nur Lailatul Masruroh, Nur Melizza, Yoyok Bekti Prasetyo, Herdianti Nur Hidayani
      Abstract: Background. Type 2 Diabetes Mellitus (T2DM) is one of the fastest-growing diseases and most serious major health problems worldwide. Few studies have focused on the association of social support with diabetes-related dietary behaviour. Objective. To examine the relationship between social support and dietary behaviour among patients with diabetes in a rural area of Indonesia. Methodology. This was a descriptive cross-sectional study that included 120 physically healthy patients above 18 years old with type 2 diabetes mellitus for at least 6 months. Data analysis was done using a stepwise regression model. Results. The mean age was 61.97 years (SD = 7.85, range = 52-74); 86.7% of the participants were females. Social support (β = 0.272, p = <0.001), diabetes medications (β = 0.169, p = 0.003), duration of diabetes (β = 0.118, p = 0.0047), and presence of diabetes complications (β = 0.197, p = 0.008) were significant predictors of dietary behaviour and accounted for 34.2% of the variance. Conclusion. Social support, diabetes medications, presence of diabetes complications, and duration of diabetes were associated with improved dietary behaviour. Therefore, social support should be considered when designing dietary interventions for patients with type 2 diabetes mellitus.
      PubDate: 2022-06-16
  • Collision of Two Tumors

    • Authors: Marisa Khatijah Borhan, Florence Hui Sieng Tan, Nur Shazwaniza Awang Basry
      Abstract: Acollision tumor involving metastasis to a pituitary adenoma is rare. We describe a case of a 68-year-old Bidayuh woman with underlying treatment-responsive lung adenocarcinoma, who presented with mass effect, panhypopituitarism and polyuria. Her initial imaging study reported pituitary macroadenoma, and she was treated with hormone replacement therapy. She then underwent transsphenoidal tumor debulking surgery with subsequent histopathological findings of a collision tumor of an adenocarcinoma with metastasis to a non-functioning pituitary adenoma.
      PubDate: 2022-06-16
  • Lower Plasma Selenoprotein P Levels in Regularly Exercising Young Adults

    • Authors: Swe Mar Oo, Min Thar Htut, Ye Win Htun, Aye Aye Mon, May Pyone Kyaw
      Abstract: Objective. Physical exercise can provide many health benefits in humans. Exercise-induced reactive oxygen species (ROS) formation and its downstream signaling cascades are reported to induce mitochondrial biogenesis in exercising tissues. Selenoprotein P (SELENOP) is the antioxidant hepatokine, whose hypersecretion is associated with various metabolic diseases.  It was reported to impair exercise-induced reactive oxygen species signaling and inhibit subsequent mitochondrial biogenesis in mice. However, the relationship between selenoprotein P and mitochondrial dynamic in humans has not yet been reported. While reduction of plasma selenoprotein P becomes an attractive therapeutic target for metabolic diseases, the role of regular exercise in this regard is still unknown. This study aimed to analyze the influence of regular habitual exercise on plasma selenoprotein P levels and its association with leucocyte mitochondrial DNA copy number in healthy young adults. Methodology. Plasma selenoprotein P levels and leucocyte mitochondrial DNA copy numbers were compared in 44 regularly exercising subjects and 44 non-exercising controls, and the correlation between the two parameters was analyzed. Plasma selenoprotein P levels were measured by Enzyme-linked Immunosorbent Assay, and leucocyte mitochondrial DNA copy numbers were measured using the qPCR method. Results. The regular-exercise group had lower plasma selenoprotein P levels with higher leucocyte mitochondrial DNA copy numbers than the non-exercise group. There was a tendency of negative correlation between the two variables in our studied population.  Conclusion. Regular habitual exercise has a beneficial effect on reducing plasma selenoprotein P levels while raising mitochondrial DNA copy numbers.
      PubDate: 2022-04-30
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