Publisher: AIP   (Total: 28 journals)   [Sort alphabetically]

Showing 1 - 27 of 27 Journals sorted by number of followers
Physics Today     Hybrid Journal   (Followers: 77, SJR: 0.66, CiteScore: 1)
J. of Applied Physics     Hybrid Journal   (Followers: 69, SJR: 0.739, CiteScore: 2)
Physics of Fluids     Hybrid Journal   (Followers: 59, SJR: 1.19, CiteScore: 3)
Applied Physics Letters     Hybrid Journal   (Followers: 51, SJR: 1.382, CiteScore: 3)
J. of Chemical Physics     Hybrid Journal   (Followers: 37, SJR: 1.252, CiteScore: 2)
J. of Mathematical Physics     Hybrid Journal   (Followers: 26, SJR: 0.644, CiteScore: 1)
Review of Scientific Instruments     Hybrid Journal   (Followers: 21, SJR: 0.585, CiteScore: 1)
J. of Laser Applications     Full-text available via subscription   (Followers: 14, SJR: 0.741, CiteScore: 2)
J. of Renewable and Sustainable Energy     Hybrid Journal   (Followers: 14, SJR: 0.44, CiteScore: 1)
Applied Physics Reviews     Hybrid Journal   (Followers: 14, SJR: 4.156, CiteScore: 12)
Physics of Plasmas     Hybrid Journal   (Followers: 11, SJR: 0.576, CiteScore: 1)
Acoustics Today     Hybrid Journal   (Followers: 10)
APL Materials     Open Access   (Followers: 10, SJR: 1.63, CiteScore: 4)
AIP Advances     Open Access   (Followers: 7, SJR: 0.472, CiteScore: 1)
Biomicrofluidics     Open Access   (Followers: 6, SJR: 0.592, CiteScore: 2)
Low Temperature Physics     Hybrid Journal   (Followers: 6, SJR: 0.264, CiteScore: 1)
Structural Dynamics     Open Access   (Followers: 6, SJR: 1.625, CiteScore: 4)
Chaos : An Interdisciplinary J. of Nonlinear Science     Hybrid Journal   (Followers: 3, SJR: 0.716, CiteScore: 2)
J. of Physical and Chemical Reference Data     Hybrid Journal   (Followers: 3, SJR: 1.046, CiteScore: 3)
Virtual J. of Quantum Information     Hybrid Journal   (Followers: 3)
AIP Conference Proceedings     Full-text available via subscription   (Followers: 2)
Biointerphases     Open Access   (Followers: 1, SJR: 0.558, CiteScore: 2)
Chinese J. of Chemical Physics     Hybrid Journal   (Followers: 1, SJR: 0.24, CiteScore: 1)
Surface Science Spectra     Hybrid Journal   (Followers: 1, SJR: 0.416, CiteScore: 1)
APL Photonics     Open Access   (Followers: 1)
Scilight     Full-text available via subscription  
APL Bioengineering     Open Access  
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Biomicrofluidics
Journal Prestige (SJR): 0.592
Citation Impact (citeScore): 2
Number of Followers: 6  

  This is an Open Access Journal Open Access journal
ISSN (Online) 1932-1058
Published by AIP Homepage  [28 journals]
  • The role of acoustofluidics and microbubble dynamics for therapeutic
           applications and drug delivery

    • Authors: S. I. Kaykanat, A. K. Uguz
      Abstract: Biomicrofluidics, Volume 17, Issue 2, March 2023.
      Targeted drug delivery is proposed to reduce the toxic effects of conventional therapeutic methods. For that purpose, nanoparticles are loaded with drugs called nanocarriers and directed toward a specific site. However, biological barriers challenge the nanocarriers to convey the drug to the target site effectively. Different targeting strategies and nanoparticle designs are used to overcome these barriers. Ultrasound is a new, safe, and non-invasive drug targeting method, especially when combined with microbubbles. Microbubbles oscillate under the effect of the ultrasound, which increases the permeability of endothelium, hence, the drug uptake to the target site. Consequently, this new technique reduces the dose of the drug and avoids its side effects. This review aims to describe the biological barriers and the targeting types with the critical features of acoustically driven microbubbles focusing on biomedical applications. The theoretical part covers the historical developments in microbubble models for different conditions: microbubbles in an incompressible and compressible medium and bubbles encapsulated by a shell. The current state and the possible future directions are discussed.
      Citation: Biomicrofluidics
      PubDate: 2023-04-10T06:26:08Z
      DOI: 10.1063/5.0130769
       
  • Capillary rise behavior of lubricant in micropores with spiral bulge
           structures

    • Authors: Guotao Zhang, Liangliang Ma, Baohong Tong, Yanguo Yin, Enzhu Hu, Karl Dearn
      Abstract: Biomicrofluidics, Volume 17, Issue 2, March 2023.
      The highly efficient exudation of lubricant in porous self-lubricating materials significantly influences the formation of self-lubricating films. In this paper, micropores with inner spiral bulge structures are considered, and their influence on the capillary behaviors of the lubricant is discussed to reveal the capillary rising mechanism. The results show that the Taylor capillary lift phenomenon is produced in the spiral bulge structure of the micropore, and the capillary lift force is enhanced. The spiral structure decreases the effective diameter of micropores. The magnitudes of the pressure and velocity in the spiral structure pores are larger than those in smooth pores. The liquid in the upper part of the micropores forms a velocity vortex during its upward rotation along the spiral channel, which promotes the capillary rising behavior. For smaller pitches, the velocity vortex increases, and the rising speed of the lubricant grows. The inner spiral bulge structure gives the micropores an excellent capillary rising ability. The quantitative characterization and mechanism reveal that the capillary rising behavior can be used to guide the bionic designs of pores in self-lubricating materials.
      Citation: Biomicrofluidics
      PubDate: 2023-04-10T06:26:06Z
      DOI: 10.1063/5.0136632
       
  • Microneedle arrays integrated with microfluidic systems: Emerging
           applications and fluid flow modeling

    • Authors: Abdollah Ahmadpour, Pelin Kubra Isgor, Berk Ural, Busra Nimet Eren, Misagh Rezapour Sarabi, Metin Muradoglu, Savas Tasoglu
      Abstract: Biomicrofluidics, Volume 17, Issue 2, March 2023.
      Microneedle arrays are patches of needles at micro- and nano-scale, which are competent and versatile technologies that have been merged with microfluidic systems to construct more capable devices for biomedical applications, such as drug delivery, wound healing, biosensing, and sampling body fluids. In this paper, several designs and applications are reviewed. In addition, modeling approaches used in microneedle designs for fluid flow and mass transfer are discussed, and the challenges are highlighted.
      Citation: Biomicrofluidics
      PubDate: 2023-04-10T06:26:05Z
      DOI: 10.1063/5.0121578
       
  • Toward droplets displaying life-like interaction behaviors

    • Authors: Claudio L. A. Berli, Martín G. Bellino
      Abstract: Biomicrofluidics, Volume 17, Issue 2, March 2023.
      Developments in synthetic biology usually bring the conception of individual artificial cells. A key feature of living systems is, however, the interaction between individuals, in which living units can interact autonomously and display a role differentiation such as the case of entities chasing each other. On the other hand, droplets have become a very useful and exciting medium for modern microengineering and biomedical technologies. In this Perspective, we show a brief discussion-outlook of different approaches to recreate predator–prey interactions in both swimmer and crawling droplet systems toward a new generation of synthetic life with impact in both fundamental insights and relevant applications.
      Citation: Biomicrofluidics
      PubDate: 2023-04-10T06:26:04Z
      DOI: 10.1063/5.0142115
       
  • Addressable microfluidics technology for non-sacrificial analysis of
           biomaterial implants in vivo

    • Authors: Minh Nguyen, Anh Tong, Mark Volosov, Shreya Madhavarapu, Joseph Freeman, Roman Voronov
      Abstract: Biomicrofluidics, Volume 17, Issue 2, March 2023.
      Tissue regeneration-promoting and drug-eluting biomaterials are commonly implanted into animals as a part of late-stage testing before committing to human trials required by the government. Because the trials are very expensive (e.g., they can cost over a billion U.S. dollars), it is critical for companies to have the best possible characterization of the materials' safety and efficacy before it goes into a human. However, the conventional approaches to biomaterial evaluation necessitate sacrificial analysis (i.e., euthanizing a different animal for measuring each time point and retrieving the implant for histological analysis), due to the inability to monitor how the host tissues respond to the presence of the material in situ. This is expensive, inaccurate, discontinuous, and unethical. In contrast, our manuscript presents a novel microfluidic platform potentially capable of performing non-disruptive fluid manipulations within the spatial constraints of an 8 mm diameter critical calvarial defect—a “gold standard” model for testing engineered bone tissue scaffolds in living animals. In particular, here, addressable microfluidic plumbing is specifically adapted for the in vivo implantation into a simulated rat's skull, and is integrated with a combinatorial multiplexer for a better scaling of many time points and/or biological signal measurements. The collected samples (modeled as food dyes for proof of concept) are then transported, stored, and analyzed ex vivo, which adds previously-unavailable ease and flexibility. Furthermore, care is taken to maintain a fluid equilibrium in the simulated animal's head during the sampling to avoid damage to the host and to the implant. Ultimately, future implantation protocols and technology improvements are envisioned toward the end of the manuscript. Although the bone tissue engineering application was chosen as a proof of concept, with further work, the technology is potentially versatile enough for other in vivo sampling applications. Hence, the successful outcomes of its advancement should benefit companies developing, testing, and producing vaccines and drugs by accelerating the translation of advanced cell culturing tech to the clinical market. Moreover, the nondestructive monitoring of the in vivo environment can lower animal experiment costs and provide data-gathering continuity superior to the conventional destructive analysis. Lastly, the reduction of sacrifices stemming from the use of this technology would make future animal experiments more ethical.
      Citation: Biomicrofluidics
      PubDate: 2023-04-03T04:29:34Z
      DOI: 10.1063/5.0137932
       
  • Recent development of microfluidics-based platforms for respiratory virus
           detection

    • Authors: Jingyu Shi, Yu Zhang, Mo Yang
      Abstract: Biomicrofluidics, Volume 17, Issue 2, March 2023.
      With the global outbreak of SARS-CoV-2, the inadequacies of current detection technology for respiratory viruses have been recognized. Rapid, portable, accurate, and sensitive assays are needed to expedite diagnosis and early intervention. Conventional methods for detection of respiratory viruses include cell culture-based assays, serological tests, nucleic acid detection (e.g., RT-PCR), and direct immunoassays. However, these traditional methods are often time-consuming, labor-intensive, and require laboratory facilities, which cannot meet the testing needs, especially during pandemics of respiratory diseases, such as COVID-19. Microfluidics-based techniques can overcome these demerits and provide simple, rapid, accurate, and cost-effective analysis of intact virus, viral antigen/antibody, and viral nucleic acids. This review aims to summarize the recent development of microfluidics-based techniques for detection of respiratory viruses. Recent advances in different types of microfluidic devices for respiratory virus diagnostics are highlighted, including paper-based microfluidics, continuous-flow microfluidics, and droplet-based microfluidics. Finally, the future development of microfluidic technologies for respiratory virus diagnostics is discussed.
      Citation: Biomicrofluidics
      PubDate: 2023-04-03T04:29:34Z
      DOI: 10.1063/5.0135778
       
  • Naturally derived colloidal rods in microfluidic flows

    • Authors: Vincenzo Calabrese, Amy Q. Shen, Simon J. Haward
      Abstract: Biomicrofluidics, Volume 17, Issue 2, March 2023.
      Naturally derived colloidal rods (CR) are promising building blocks for developing sustainable soft materials. Engineering new materials based on naturally derived CR requires an in-depth understanding of the structural dynamics and self-assembly of CR in dispersion under processing conditions. With the advancement of microfabrication techniques, many microfluidic platforms have been employed to study the structural dynamics of CR under flow. However, each microfluidic design has its pros and cons which need careful evaluation in order to fully meet the experimental goal and correctly interpret the data. We analyze recent results obtained from naturally derived CR and relevant rod-like macromolecules under microfluidic flows, with emphasis on the dynamical behavior in shear- and extensional-dominated flows. We highlight the key concepts required in order to assess and evaluate the results obtained from different CR and microfluidic platforms as a whole and to aid interconnections with neighboring fields. Finally, we identify and discuss areas of interest for future research directions.
      Citation: Biomicrofluidics
      PubDate: 2023-04-03T04:29:33Z
      DOI: 10.1063/5.0142867
       
  • Acoustofluidic separation of proteins from platelets in human blood plasma
           using aptamer-functionalized microparticles

    • Authors: Song Ha Lee, Beomseok Cha, Jeongu Ko, Muhammad Afzal, Jinsoo Park
      Abstract: Biomicrofluidics, Volume 17, Issue 2, March 2023.
      Microfluidic liquid biopsy has emerged as a promising clinical assay for early diagnosis. Herein, we propose acoustofluidic separation of biomarker proteins from platelets in plasma using aptamer-functionalized microparticles. As model proteins, C-reactive protein and thrombin were spiked in human platelet-rich plasma. The target proteins were selectively conjugated with their corresponding aptamer-functionalized microparticles of different sizes, and the particle complexes served as a mobile carrier for the conjugated proteins. The proposed acoustofluidic device was composed of an interdigital transducer (IDT) patterned on a piezoelectric substrate and a disposable polydimethylsiloxane (PDMS) microfluidic chip. The PDMS chip was placed in a tilted arrangement with the IDT to utilize both vertical and horizontal components of surface acoustic wave-induced acoustic radiation force (ARF) for multiplexed assay at high-throughput. The two different-sized particles experienced the ARF at different magnitudes and were separated from platelets in plasma. The IDT on the piezoelectric substrate could be reusable, while the microfluidic chip can be replaceable for repeated assays. The sample processing throughput with the separation efficiency>95% has been improved such that the volumetric flow rate and flow velocity were 1.6 ml/h and 37 mm/s, respectively. For the prevention of platelet activation and protein adsorption to the microchannel, polyethylene oxide solution was introduced as sheath flows and coating on to the walls. We conducted scanning electron microscopy, x-ray photoemission spectroscopy , and sodium dodecyl sulfate- analysis before and after the separation to confirm the protein capture and separation. We expect that the proposed approach will provide new prospects for particle-based liquid biopsy using blood.
      Citation: Biomicrofluidics
      PubDate: 2023-04-03T04:29:33Z
      DOI: 10.1063/5.0140096
       
  • On-chip dielectrophoretic device for cancer cell manipulation: A numerical
           and artificial neural network study

    • Authors: Rasool Mohammadi, Hadi Afsaneh, Behnam Rezaei, Mahdi Moghimi Zand
      Abstract: Biomicrofluidics, Volume 17, Issue 2, March 2023.
      Breast cancer, as one of the most frequent types of cancer in women, imposes large financial and human losses annually. MCF-7, a well-known cell line isolated from the breast tissue of cancer patients, is usually used in breast cancer research. Microfluidics is a newly established technique that provides many benefits, such as sample volume reduction, high-resolution operations, and multiple parallel analyses for various cell studies. This numerical study presents a novel microfluidic chip for the separation of MCF-7 cells from other blood cells, considering the effect of dielectrophoretic force. An artificial neural network, a novel tool for pattern recognition and data prediction, is implemented in this research. To prevent hyperthermia in cells, the temperature should not exceed 35 °C. In the first part, the effect of flow rate and applied voltage on the separation time, focusing efficiency, and maximum temperature of the field is investigated. The results denote that the separation time is affected by both the input parameters inversely, whereas the two remaining parameters increase with the input voltage and decrease with the sheath flow rate. A maximum focusing efficiency of 81% is achieved with a purity of 100% for a flow rate of [math] and a voltage of [math]. In the second part, an artificial neural network model is established to predict the maximum temperature inside the separation microchannel with a relative error of less than 3% for a wide range of input parameters. Therefore, the suggested label-free lab-on-a-chip device separates the target cells with high-throughput and low voltages.
      Citation: Biomicrofluidics
      PubDate: 2023-03-06T05:15:21Z
      DOI: 10.1063/5.0131806
       
  • Nanogap traps for passive bacteria concentration and single-point confocal
           Raman spectroscopy

    • Authors: Jung Y. Han, Michael Yeh, Don L. DeVoe
      Abstract: Biomicrofluidics, Volume 17, Issue 2, March 2023.
      A microfluidic device enabling the isolation and concentration of bacteria for analysis by confocal Raman spectroscopy is presented. The glass-on-silicon device employs a tapered chamber surrounded by a 500 nm gap that serves to concentrate cells at the chamber apex during sample perfusion. The sub-micrometer gap retains bacteria by size exclusion while allowing smaller contaminants to pass unimpeded. Concentrating bacteria within the fixed volume enables the use of single-point confocal Raman detection for the rapid acquisition of spectral signatures for bacteria identification. The technology is evaluated for the analysis of E. cloacae, K. pneumoniae, and C. diphtheriae, with automated peak extraction yielding distinct spectral fingerprints for each pathogen at a concentration of 103 CFU/ml that compare favorably with spectra obtained from significantly higher concentration reference samples evaluated by conventional confocal Raman analysis. The nanogap technology offers a simple, robust, and passive approach to concentrating bacteria from dilute samples into well-defined optical detection volumes, enabling rapid and sensitive confocal Raman detection for label-free identification of focused cells.
      Citation: Biomicrofluidics
      PubDate: 2023-03-06T05:15:07Z
      DOI: 10.1063/5.0142118
       
 
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