Publisher: Serbian Chemical Society (Total: 1 journals)   [Sort alphabetically]

Showing 1 - 1 of 1 Journals sorted by number of followers
J. of the Serbian Chemical Society     Open Access   (SJR: 0.223, CiteScore: 1)
Similar Journals
Journal Cover
Journal of the Serbian Chemical Society
Journal Prestige (SJR): 0.223
Citation Impact (citeScore): 1
Number of Followers: 0  

  This is an Open Access Journal Open Access journal
ISSN (Print) 0352-5139 - ISSN (Online) 1820-7421
Published by Serbian Chemical Society Homepage  [1 journal]
  • Apoptosis induction in HeLa cervical cancer cell line by steroidal

    • Authors: Lidija Aleksić, Andrea Nikolić, Vesna Kojić, Marija Sakač, Suzana Јovanović-Šanta
      Pages: 969 - 981
      Abstract: Steroids are good candidates for drug development, thanks to their low general toxicity and possibility for structure modifications connected with change of their activity. Several 16,17-secoandrost-4-ene-16,17a-dinitrile com­pounds were syn­thesized and screened for anticancer effect previously, inc­luding 6-oxo and 6-hy­droxyimino compounds. This research is continued with the attempts for dif­fer­ent synthetic strategy and evaluation of anticancer effect mechanism. Syn­thesis of 3-hydroxyimino compounds was successful, but inseparable mix of isomers was excluded from biological tests. Tested seco­di­nitriles expressed cyto­toxic effect on HeLa cervix cancer cells as a model sys­tem, with submicromolar to molar IC50 values, where 6-substituted derivatives were more effective. After 72 h treatment with equitoxic concentrations equal IC50 values of test com­pounds the mechanism of this effect was studied using flow cytometry and specific fluorescent dyes. Mod­est change in both G0/G1 and G2/M resting phases and change in mito­chondrial membrane potential were noticed, while the most prono­unced effect was apoptosis induction. Total apoptosis was in range 50.72–58.31 % in all cell samples treated with secodi­nit­riles, compared to 7.44 % in control samples. Total percent of dead cells, including both apoptotic and necrotic, ranged from 55.24 to 65.34 %, com­pared to 10.68 % in control. Selectivity towards cancer cells is very important feat­ure of these compounds indicating their potential use as lead compounds in the drug development for the treatment of cancers of steroid hormone-dependent tissues.
      PubDate: 2022-08-01
      DOI: 10.2298/JSC210723035A
      Issue No: Vol. 87, No. 9 (2022)
  • Melissopalynology analysis, determination of physicochemical parameters,
           sugars and phenolics in Maltese honey collected in different seasons

    • Authors: Adrian Bugeja Douglas, Milica Nešović, Branko Šikoparija, Predrag Radišić , Tomislav Tosti, Jelena Trifković, Luigi Russi, Everaldo Attard, Živoslav Tešić, Uroš Gašić
      Pages: 983 - 995
      Abstract: Malta, a country renowned for its honey, has not been extensively mentioned in studies based on honey. In addition to many parameters, the col­lection period affects honey quality, precisely due to the different floral com­position that exists during a certain season. Therefore, the significance of this study refers to the provision of data on honey from Malta collected during the autumn, spring, and summer seasons. Melissopalynological analysis, deter­mi­nation of physicochemical parameters, and the use of analytical chromato­graphic methods enabled detailed analysis of this honey. Principal component analysis (PCA) provided the differentiation of Maltese honey depending on the harvest season. Lotus pollen, followed by Eucalyptus, predominated in all honey samples. Characteristic compounds for summer honey were pinocem­brin, galangin, kaempferol, chrysin, p-hydroxybenzoic acid, vanillic acid and maltotriose, while quercetin 3-O-galactoside, ferulic acid, ellagic acid, proto­catechuic acid, luteolin 7-O-glucoside and melibiose were specific for autumn honey. A higher amount of p-coumaric acid, genistein, catechin, as well as the content of many sugars were found in spring samples. To the best of our knowledge, this is the first scientific work dealing with a detailed chemical analysis of Mal­tese honey.
      PubDate: 2022-07-22
      DOI: 10.2298/JSC211214033B
      Issue No: Vol. 87, No. 9 (2022)
  • Statistical optimization of lipase production from oil mill effluent by
           Acinetobacter sp. KSPE71

    • Authors: Selvapriya Kumarswamy, Jayanthi Singaram
      Pages: 997 - 1010
      Abstract: The present study investigated the valorisation of oil-rich residues of coconut oil mill effluent (COME) as a potential growth medium for the micro­bial production of extracellular lipase. The bacterial species isolated from oil mill effluent, Acinetobacter sp. KSPE71 was tested for its efficiency to grow and produce lipase in undiluted COME and 0.2 % yeast extract and 0.2 % NH4Cl sup­plemented COME. In this connection, the process parameters such as pH, tem­pe­rature, agitation speed, and inoculum size were optimized to max­i­mize the produc­tion using a central composite design in the Response surface methodology. At the optimized state of pH 7.5, 35 °C, 150 rpm with 0.6 % ino­culum size, a maximum of 3.95 U mL-1 activity was obtained, four-fold higher than the basal condition. At this stage, 73 % of the lipid content was degraded. The present work results imply that the oil mill effluent can be used as a cheaper production medium for lipase and the new isolate Acinetobacter sp. KSPE71 as a potential lipase pro­ducer. The degradation of oil waste along with the production of the valuable pro­duct has multiple advantages of cost reduct­ion of lipase and environmental concern.
      PubDate: 2022-07-22
      DOI: 10.2298/JSC220119038K
      Issue No: Vol. 87, No. 9 (2022)
  • Advanced dye removal by multifunctional layered double hydroxide based
           materials: Adsorption and kinetic studies

    • Authors: Milica Hadnađev Kostić, Tatjana Vulić, Đurđica Karanović, Marija Milanović
      Pages: 1011 - 1024
      Abstract: Due to favourable properties layered double hydroxides (LDHs) have been widely investigated for organic dye removal processes. In order to study the adsorption of methyl orange, bimetal (ZnAl and MgAl) and trimetal (ZnCuAl and MgCuAl) adsorbents were synthesized and thermally treated. The influence of adsorbent metal nature and content on structural (X-ray diffract­ion, Raman analysis), textural (low temperature nitrogen adsorption) and ads­orption pro­perties was investigated. Adsorption behaviour, mech­anisms, and stability of synthesized LDHs and their calcined mixed oxides were studied with the aim to elucidate the adsorbent-dye interactions, enabling optimization of experimental design. All LDH adsorbents and LDH derived mixed oxide adsorbents had high removal efficiency rate, especially Zn-con­taining mixed oxides where complete decolourization (100 % of dye removal) was achieved almost instantly due to super-fast adsorbent-adsorbate interact­ion. Two pos­sible adsorption mechanisms initiated by interfacial phenomena were in correl­ation with the structural and textural properties, as well as with the “memory effect” reconstruction phenomenon. These results present a solid base for further investigation and design of LDH-based adsorbents for the Methyl orange removal, considering their favourable structural and textural properties and excellent adsorption capacities.
      PubDate: 2022-08-01
      DOI: 10.2298/JSC220228034H
      Issue No: Vol. 87, No. 9 (2022)
  • Laboratory data clustering in defining population cohorts: Case study on
           metabolic indicators

    • Authors: Ivan Pavićević, Goran Miljuš, Olgica Nedić
      Pages: 1025 - 1033
      Abstract: The knowledge on the general population health is important for creating public policies and organization of medical services. However, per­sonal data are often limited, and mathematical models are employed to achieve a general overview. Cluster analysis was used in this study to assess general trends in po­pulation health based on laboratory data. Metabolic indicators were chosen to test the model and define population cohorts. Data on blood analysis of 33,049 persons, namely the concentrations of glucose, total cholesterol and triglycerides, were col­lected in a public health laboratory and used to define metabolic cohorts employing computational data clustering (CLARA method). The population was shown to be distributed in 3 clusters: persons with hyper­cholesterolemia with or without changes in the concentration of triglycerides or glucose, persons with reference or close to reference concentrations of all three analytes and persons with predo­mi­nantly elevated all three parameters. Clus­tering of biochemical data, thus, is a use­ful statistical tool in defining popul­ation groups in respect to certain health aspect.
      PubDate: 2022-07-22
      DOI: 10.2298/JSC220106037P
      Issue No: Vol. 87, No. 9 (2022)
  • Oxide coatings with immobilized Ce-ZSM5 as visible light photocatalysts

    • Authors: Nikola Božović, Kristina Mojsilović, Srna Stojanović, Ljiljana Damjanović-Vasilić, Maria Serdechnova, Carsten Blawert, Mikhail L. Zheludkevich, Stevan Stojadinović, Rastko Vasilić
      Pages: 1035 - 1048
      Abstract: The preparation and properties of oxide coatings with immobilized ZSM-5 zeolite obtained by plasma electrolytic oxidation on aluminum support were investigated and discussed. Pure and Ce-exchanged ZSM-5 were immo­bilized on aluminum supports from a silicate-based electrolyte under ultra-low duty cycle pulsed direct current conditions. The obtained composite coatings were characterized with respect to their morphology, phase and chemical com­position, as well as photocatalytic activity and anti-corrosion properties. All mentioned properties of the obtained coatings were dependent on the proces­sing time. The coatings with Ce-exchanged ZSM-5 showed higher photocat­alytic activity and more effective corrosion protection than those with pure ZSM-5. The highest photocatalytic activity was observed for coatings pro­cessed for 30 min. It is suggested that the surface morphology, Ce-content and number of defects influenced the photocatalytic activity of the composite coat­ings.
      PubDate: 2022-08-26
      DOI: 10.2298/JSC211203058B
      Issue No: Vol. 87, No. 9 (2022)
  • Extraordinary regularities of zinc dendrites’ growth under
           appropriate electrolysis conditions

    • Authors: Dimitar Gramatikov, Svetomir Hadži Jordanov
      Pages: 1049 - 1062
      Abstract: A case study is given of dendritic growth during zinc electrolysis in conditions that promote it. Subject of the main interest was how the electrolysis parameters affect the duration of dendrites life. The selected set of parameters did provide a surprisingly regular dendrite’s life, i.e., period from start of the electrolysis until dendrites detachment from the cathode. Dendrite’s growth did proceed with lowering of the zinc current efficiency, and the end of life was manifested by intensive hydrogen evolution due to corrosion of detached zinc deposit in the acid electrolyte. Current efficiency was successfully followed by the bubble counting technique, invented especially for kinetic studies of gas including reactions. The acquired results on dendrites’ life duration were so exact that it was easy to unify all five mono-variable dependencies into one five-variable expression. The calculated values of life duration did differ from the measured ones by only ±3 %! This is a proof that the developed expression accurately presents the real nature of dendritic growth under the applied con­ditions, i.e., 0.5 to 2 M zinc (II) ions, 0.41 to 3.06 M H2SO4, 10 to 2500 mg dm-3 copper (II) ions, 0.14 to 14 g dm-3 hexamethylenetetramine, and 4.25 to 103 mA dm-2 current density. The eventual broader region of Zn dendrites’ strict regular growth is not excluded.
      PubDate: 2022-07-22
      DOI: 10.2298/JSC220122029G
      Issue No: Vol. 87, No. 9 (2022)
  • The RP-HPLC method for analysis of usnic acid as potential marker of
           herbal drugs-based formulations containing Usnea barbata

    • Authors: Vanja Tadić, Ana R. Žugić, Sofija Đorđević, Irena Žižović, Irena Homšek, Dušan Mišić, Ivana Nešić
      Pages: 1063 - 1073
      Abstract: The aim of this study was to develop and validate a sensitive RP-HPLC method for the determination of usnic acid, as a potential marker sub­stance of the herbal product for oromucosal use being a complex mixture of plant extracts and an essential oil, including the extract of Usnea barbata. Ana­lysis of usnic acid in the tested formulation was performed through an extract­ion with methanol, prior to injection onto the HPLC column (Zorbax Eclipse XDB-C18 600 Bar (4.6 mm×100 mm, 1.8 μm)). The employed gradient pro­cedure of the solvents (phosphoric acid (pH 2.5) and acetonitrile), at flow rate of 0.1 mL min-1 allowed for the efficient and reproducible separation of usnic acid from the other compounds present in the investigated complex mixture. The established suitability, linearity, precision, accuracy and selectivity/spe­cif­icity of this assay implied its applicability for the reli­able examination in the stability study of the investigated multi-ingredient herbal preparation.
      PubDate: 2022-08-01
      DOI: 10.2298/JSC201216045T
      Issue No: Vol. 87, No. 9 (2022)
  • Star-shaped poly(ε-caprolactones) with well-defined architecture as
           potential drug carriers

    • Authors: Marijana Ponjavić, Marija S. Nikolić, Sanja Jevtić, Sanja Jeremić, Lidija Đokić, Jasna Đonlagić
      Pages: 1075 - 1090
      Abstract: The present study reports the potential application of star-shaped poly(ε-caprolactones) with different number of arms as new drug delivery mat­rix. Linear and star-shaped PCL ibuprofen loaded microspheres were prepared using oil-in-water (o/w) solvent evaporation technique and characterized with FTIR, DSC, XRD and SEM analysis. High yield, encapsulation efficiency and drug loadings were obtained for all microspheres. FTIR analysis revealed the existence of interactions between polymer matrix and drug, while the DSC ana­lysis suggested that drug was encapsulated in an amorphous form. SEM ana­lysis confirmed that regular, spherical in shape star-shaped microspheres, with diameter between 80 and 90 μm, were obtained, while quite larger micro­spheres, 110 μm, were pre­pared from linear PCL. The advantage of using star-shaped PCL microspheres in­stead of linear PCL was seen from drug release profiles which demonstrated higher amount of drug released from star-shaped polymer matrix as a consequence of their branched, flexible structure. Micro­spheres prepared from the polymers with the most branched structure showed the highest amount of the released drug after 24 h. Finally, cytotoxicity tests, performed using normal human fibroblasts (MRC5), indicated the absence of cytotoxicity at lower concentrations of microspheres proving the great potential of star-shaped PCL systems in comparison to linear ones.
      PubDate: 2022-07-22
      DOI: 10.2298/JSC220202032P
      Issue No: Vol. 87, No. 9 (2022)
  • Leaching of heavy metals from wood biomass ash, before and after binding
           in cement composite

    • Authors: Dijana Drljača, Ljiljana Vukić, Dajana Dragić, Aleksandra Borković, Tatjana Botić, Pero Dugić, Saša Papuga, Marko Šolić, Snežana Maletić, Petar Gvero, Jelena Savković
      Pages: 1091 - 1108
      Abstract: Wood ash is a complex mixture of inorganic and organic compounds. It is heterogeneous in composition, which can vary considerably. Ash is mainly disposed of in landfills, which creates a risk for air, soil and groundwater con­tamination by trace elements. In order for wood biomass ash to be used as a secondary raw material, it is necessary to perform leaching tests, to determine which microelements it contains, and which of them could be released into the environment during the ash disposal. Sequential extraction (SE) showed that in the exchangeable and carbonate fraction, the most volatile metals As, Cd, Zn and Pb are released the most from the ash of deciduous trees, while the leach­ing of ash from coniferous trees is significantly lower. The evaluation of risk assessment code (RAC) for the tested biomass ash samples, indicates that Pb is a high-risk leaching element due to its condensation on the ash particles. By performing toxicity characteristic leaching procedure (TCLP) and synthetic precipitation leaching procedure (SPLP) tests, it was established that the rel­eased concentrations of tested metals are below the maximum allowable con­cen­tration, given by the regulation. The leaching tests of composites, prepared from wood ash in combination with cement, indicate that the leaching of ash is reduced to a minimum, and that all heavy metals are bound in a cement matrix, which indicates the possibility of using wood ash for construction purposes.
      PubDate: 2022-08-01
      DOI: 10.2298/JSC220217054D
      Issue No: Vol. 87, No. 9 (2022)
School of Mathematical and Computer Sciences
Heriot-Watt University
Edinburgh, EH14 4AS, UK
Tel: +00 44 (0)131 4513762

Your IP address:
Home (Search)
About JournalTOCs
News (blog, publications)
JournalTOCs on Twitter   JournalTOCs on Facebook

JournalTOCs © 2009-