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Gynecology Obstetrics & Reproductive Medicine     Open Access   (Followers: 1)
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Gynecology Obstetrics & Reproductive Medicine
Number of Followers: 1  

  This is an Open Access Journal Open Access journal
ISSN (Print) 1300-4751
Published by Medical Network Homepage  [1 journal]
  • Fetal Thymus Size in Pregnant Women with COVID-19 Infection

    • Authors: Sule Goncu Ayhan, Deniz Oluklu, Selcan Sinaci, Aysegul Atalay, Seyit Ahmet Erol, Eda Ozden Tokalioglu, Muradiye Yildirim, Ozlem Moraloglu Tekin, Dilek Sahin
      Pages: 84 - 88
      Abstract: OBJECTIVE: To determine the effect of SARS-CoV-2 infection on fetal thymus size by ultrasound. STUDY DESIGN: In this prospective study sonographic fetal thymus size was measured in pregnant women attending our hospital with confirmed SARS-CoV-2 infection by RT-PCR test and age-matched control group. The anteroposterior thymic and the intrathoracic mediastinal diameter was determined in the three-vessel view and their quotient, the thymic-thoracic ratio, was calculated. Results were compared between these two groups. RESULTS: Thirty-six SARS-CoV-2-infected and 47 control group pregnant women were included in this study. Two groups were similar in terms of demographic features and no difference was found for fetal thymus size. CONCLUSION: COVID-19 seems to have no adverse effect on fetal thymus size in mild and moderate patients during the acute phase of the infection.
      PubDate: 2021-08-02
      DOI: 10.21613/GORM.2021.1222
      Issue No: Vol. 27, No. 2 (2021)
  • Does Larger Fetal Ascending Aorta Than the Pulmonary Artery Indicate Major
           Cardiac Anomaly'

    • Authors: Safak Yilmaz Baran, Alev Arslan, Gulsen Dogan Durdag, Hakan Kalayci, Seda Yuksel Simsek, Songul Alemdaroglu
      Pages: 89 - 93
      Abstract: OBJECTIVE: This study investigated the cases in which the fetal ascending aorta is larger than the main pulmonary artery on the three-vessel view and aimed to determine the relationship between the larger ascending aorta and major cardiac anomalies.STUDY DESIGN: Pregnancies between 18-24 gestational weeks who underwent detailed second-trimester screening during 2015-2019 were evaluated. Cases whose fetal ascending aorta diameter was larger than fetal main pulmonary artery diameter on the three-vessel view despite normal four-chamber view were analyzed. Prenatal and postnatal echocardiography studies were performed for each case.RESULTS: Fetal ascending aorta diameter larger than fetal main pulmonary artery diameter on the three-vessel view despite normal four-chamber view was detected in 21 fetuses in a total of 3810 pregnancies (0.55%), and 10 (47.6%) of them had major congenital heart disease. The diagnosis of Tetralogy of Fallot, double outlet right ventricle, ventricular septal defect, pulmonary valve stenosis, and moderate to severe tricuspid regurgitation were confirmed with prenatal/postnatal echocardiography studies. The highest ratio of ascending aorta/main pulmonary artery was 1.4 in a fetus with a double outlet right ventricle and pulmonary valve stenosis.CONCLUSION: The fetal ratio of ascending aorta/main pulmonary artery larger than 1 on the three-vessel view may be a sign of certain cardiac anomalies. Nevertheless, this rate is not an indicator of a serious cardiac defect in all cases. Fetal advanced echocardiography and early postnatal cardiac evaluation should be done to confirm the diagnosis.
      PubDate: 2021-08-02
      DOI: 10.21613/GORM.2020.1060
      Issue No: Vol. 27, No. 2 (2021)
  • Pregnancy Wastage Due to Fetal Congenital Malformations

    • Authors: Vijayata Sangwan, Shivani Khandelwal, Rajiv Mahendru, Pinkey Lakra, Sunita Siwach
      Pages: 94 - 98
      Abstract: OBJECTIVES: To study the pattern of various congenital anomalies in rural Haryana.
      STUDY DESIGN: This was a retrospective study conducted over 1 and ½ years (from January 2015 to June 2016) in a tertiary care center in Haryana, India.RESULTS: Out of 11,178 births, 227 babies had gross congenital malformations 2.03%. In literature, the most common birth defect reported in western countries is cardiovascular anomalies while in India and eastern countries, it’s the neural tube defect. In our study also, neural tube defects were the most common congenital anomalies accounting for 64.31% of total anomalies. They were more common in unbooked patients (70%) and the rural population. So, the main cause appears to be a lack of awareness and illiteracy.CONCLUSION: There is a need for increased awareness and folic acid supplementation routinely in the periconceptional period to decrease the incidence of congenital anomalies.
      PubDate: 2021-08-02
      DOI: 10.21613/GORM.2020.1095
      Issue No: Vol. 27, No. 2 (2021)
  • Placental Maspin Gene Expression Pattern May Be Used to Distinguish
           Between Preeclampsia and Intrauterine Growth Restriction

    • Authors: Gogsen Onalan, Yunus Kasim Terzi, Yusuf Aytac Tohma, Erkan Yurtcu, Esra Kuscu, Feride Iffet Sahin, Hulusi Bulent Zeyneloglu
      Pages: 99 - 104
      Abstract: Objective: Maspin is one of the members of serin protease inhibitor superfamily, and acts as a tumor suppressor protein. Here we report maspin expression in placental tissues of preeclampsia or intrauterine growth retardation pregnancies.Study Design: Maspin expression level was analyzed by semi-quantitative RT-PCR method. For this purpose, placental tissue samples were obtained from pregnancies 13 with intrauterine growth retardation, and 6 with preeclampsia, and also 12 tissues from women without preeclampsia or intrauterine growth retardation history were included as controls. Results: Maspin expression was found to be 11-fold higher in placentas from preeclampsia patients than placentas from intrauterine growth retardation patients (p=0.036). However, there was no difference between preeclampsia and control groups (p=0.76), and intrauterine growth retardation and control groups (p=0.849).Conclusion: As far as we know this is the first study reporting expression level of maspin in placental tissues of pregnancies with intrauterine growth retardation. These findings support that molecular pathology between preeclampsia and IUGR might be different at the molecular level and maspin levels in the placenta may be used to differentiate preeclampsia from IUGR.
      PubDate: 2021-08-02
      DOI: 10.21613/GORM.2019.969
      Issue No: Vol. 27, No. 2 (2021)
  • Are the Mean Platelet Volume and Neutrophil/Lymphocyte Ratio Predictive
           for Gestational Cholestasis'

    • Authors: Hasan Eroglu, Harun Egemen Tolunay, Kemal Sarsmaz, Gokcen Orgul, Dilek Sahin, Aykan Yucel
      Pages: 105 - 108
      Abstract: OBJECTIVES: We aimed to determine whether mean platelet volume value and/or neutrophil/lymphocyte ratio values are useful as a predictive marker for gestational cholestasis.
      STUDY DESIGN: Retrospective analysis of the data of patients diagnosed with pregnancy cholestasis between 2018-2019 in a perinatology clinic. 352 pregnant women were enrolled in the study (122 pregnant women with Intrahepatic cholestasis as study group and 230 pregnant women with no morbidity as the control group)
      RESULTS: Mean platelet volume was significantly higher in pregnant women with intrahepatic cholestasis compared to the healthy controls, 9.30 (7-18) and 8.6 (6.7-11.5), respectively. The neutrophil/lymphocyte ratio was significantly higher in pregnant women with intrahepatic cholestasis compared to the healthy controls, 3.93 (0.46-13.75) and 4.25 (0.87-17.1), respectively. There was a statistically significant difference between the two groups for mean platelet volume (p <0.001). In the roc analysis, 8.85 fL for mean platelet volume had a sensitivity of 65% and a specificity of 59%.CONCLUSION: When compared with healthy pregnancies, mean platelet volume value in gestational cholestasis increases significantly. However, the predictive strength of mean platelet volume for cholestasis is not strong enough to recommend its usage as a single parameter in clinical practice.
      PubDate: 2021-08-02
      DOI: 10.21613/GORM.2020.1064
      Issue No: Vol. 27, No. 2 (2021)
  • Differences in Sexual Function Between Trimesters During Pregnancy: An
           Observational Study

    • Authors: Sunullah Soysal, Abdullah Sarioz, Umran Kilincdemir Turgut, Gokce Anik Ilhan, Yusuf Arman, Begum Yildizhan, Tanju Pekin
      Pages: 109 - 115
      Abstract: OBJECTIVE: The aim of this study was to evaluate differences in sexual function between trimesters, and factors (in addition to pregnancy) that influence sexual function during pregnancy.STUDY DESIGN: This observational study was conducted at a tertiary referral center with 372 pregnant women. Seventy-two of the women did not complete the questionnaire (rejections or missing data) and the overall response rate was 80.6%. Among the remaining women, 43 of them excluded due to depression. Beck Depression Inventory was used to evaluate depression. Index of female sexual function questionnaire was used to assess sexual function. Index of female sexual function had a total and six sub-domain scores which assess the quality and frequency of sexual intercourse, desire, overall satisfaction, ability to achieve orgasm, and degree of clitoral sensation (c.sensation).RESULTS: Total index of female sexual function and quality, satisfaction, orgasm, and c.sensation sub-domain scores were lowest in the third trimester. Older age, lower level of education, and lower level of income negatively affected total index of female sexual function scores. Quality scores were lowest in older women and women with lower education. Frequency scores were highest during the second trimester. Desire scores were highest in women aged between 18 and 25 years, in women who were newly married (1-3 years), and during the second trimester. Satisfaction scores were lowest in women older than 35 years, and highest in newly married women. Orgasm scores were highest in women aged 18-25 years, in newly married women. CONCLUSIONS: Sexual function in women during the third trimester of pregnancy is generally affected negatively.
      PubDate: 2021-08-02
      DOI: 10.21613/GORM.2020.1073
      Issue No: Vol. 27, No. 2 (2021)
  • The Usefulness of Intrapartum Transperineal Ultrasonography for the
           Prediction of Mode of Delivery

    • Authors: Erdinc Saridogan, Ozlem Moraloglu Tekin
      Pages: 116 - 122
      Abstract: OBJECTIVE: We aimed to assess the accuracy of intrapartum transperineal ultrasonography that is non-invasive, easy to learn, rapid to perform, comfortable for pregnant women, and low-cost method to evaluate the progress of labor objectively.STUDY DESIGN: We evaluated two hundred-ten singleton pregnant women at term with cephalic presentation who went into active labor via intrapartum transperineal ultrasonography using the angle of progression and head-perineum distance. Maternal characteristics, conventional vaginal examination findings, mode of delivery, and neonatal results were noted. The data were compared using correlation and regression analysis.
      RESULTS: The relationships between the descent of clinical fetal head station, the increase of angle of progression (p=0.001), and the decrease of head-perineum distance (p=0.001) were statistically significant. The receiver operating characteristics curve showed that measurement of angle of progression with <110.5 degrees (p=0.001) and measurement of head-perineum distance with >52.5 millimeters (p=0.001) were associated with emergent cesarean delivery. For the prediction of delivery mode, both angle of progression and head-perineum distance had high sensitivity and specificity.CONCLUSIONS: Intrapartum transperineal ultrasonography parameters were in agreement with each other and conventional vaginal examination for determination of delivery mode. Head-perineum distance was a parity-dependent measurement whilst angle of progression was parity-independent.
      PubDate: 2021-08-02
      DOI: 10.21613/GORM.2020.1031
      Issue No: Vol. 27, No. 2 (2021)
  • Oxytocin Versus Dinoprostone For Labor Induction in Multiparous Women with
           Unfavorable Cervix

    • Authors: Gul Nihal Buyuk, Umit Yasemin Sert, Zeynep Asli Oskovi Kaplan, Serkan Kahyaoglu
      Pages: 123 - 127
      Abstract: OBJECTIVE: Dinoprostone is a drug of choice in our daily practice for the induction of labor. The aim of our study; to compare the use of oxytocin with dinoprostone (PGE2- Propess©) used in term multiparous pregnant women to ripen the cervix.STUDY DESIGN: A total of 507 patients were included in the study. Group A, consisted of 262 women with term multiparous pregnancy Bishop score ≤6 underwent induction of labor with a vaginal insert containing 10-mg timed-release dinoprostone (Propess© -prostaglandin E2). Group B, consisted of 245 cases of pregnancy with Bishop score ≤6 underwent induction of labor with iv oxytocin and was matched for the patient's age and parity. The following data were recorded: age, gestational age, body mass index, the time from the drug administration to the vaginal labor, delivery mode, indications of induction, cesarean indication, birth weight, Apgar score, and need of neonatal intensive care unit. RESULTS: The primary outcome of the in group B interval from induction to vaginal delivery was similar between the two groups. In group A, 41 patients and in group B, 23 patients had a cesarean section. Cesarean section rate was lower in the oxytocin group (cesarean rate 15.6% versus 9.3%, p<0.05). CONCLUSION: It appears; Dinoprostone ovule increases the cesarean rate in terms, multiparous cases with inappropriate cervical score and does not shorten the duration of delivery. Therefore, the use of oxytocin for cervical ripening in multiparous women may be a more appropriate option.
      PubDate: 2021-08-02
      DOI: 10.21613/GORM.2020.1039
      Issue No: Vol. 27, No. 2 (2021)
  • Miscarriage Rates Due to Endometriosis: A Retrospective Cohort Study

    • Authors: Pinar Calis, Gizem Isik, Dilara Duygulu, Nuray Bozkurt, Deniz Karcaaltincaba
      Pages: 128 - 131
      Abstract: OBJECTIVE: To find the differences of miscarriage rates between pregnant patients with and without endometriosis. STUDY DESIGN: The retrospective cohort study was conducted in the Department of Obstetrics and Gynecology, School of Medicine, Gazi University between January-2015 and December-2018. Patients were divided into two groups; endometriosis and non-endometriosis according to their pathology report and ultrasound examination. In both groups, miscarriage rates and in vitro fertilization pregnancy ratios were analyzed. Miscarriage rates in in vitro fertilization pregnancies and in endometriosis group who had and didn't have surgery also analyzed.RESULTS: Sixty-two patients in the study group and 65 patients in the control group were included. There was no significant difference in miscarriage rates between endometriosis and non-endometriosis group (20/62 (32%) and 13/65 (20%), respectively, p=0.124). There was a statistically significant difference in miscarriage rates between in vitro fertilization and non-in vitro fertilization group (p=0.004). Apart from that, in in vitro fertilization group, the miscarriage rate was higher in the endometrioma subgroup than non-endometrioma (p=0.008).CONCLUSION: There was an only significant difference in miscarriage rate in the in vitro fertilization group between endometrioma and non-endometrioma patients. In the future, there should be more studies to define the actual pathophysiology for miscarriage with endometriosis.
      PubDate: 2021-08-02
      DOI: 10.21613/GORM.2020.1058
      Issue No: Vol. 27, No. 2 (2021)
  • Is There a Role of 25-Hydroxy Vitamin D in the Pathogenesis of Mild and
           Moderate-to-Severe Endometriosis'

    • Authors: Nevin Tuten, Serdar Acikgoz, Zahid Mammadov, Eduard Malik, Abdullah Tuten, Onur Guralp
      Pages: 132 - 137
      Abstract: Objective: To evaluate the possible associations between serum 25-hydroxy vitamin D levels and clinical and laboratory parameters in endometriosis.Study design: A total of 53 women with endometriosis and 37 women without endometriosis were evaluated in a, case-controlled study. The demographic features, clinical, and laboratory parameters of the two groups were compared.Results: The serum 25-hydroxy vitamin D levels were significantly decreased in both stage 1-2 and stage 3-4 groups compared to the controls (p<0.001 and p<0.001); although the difference between the stage 1-2 and stage 3-4 groups remained nonsignificant. The serum 25-hydroxy vitamin D levels had no correlation with the presence of infertility, deep infiltrating endometriosis, or Douglas pouch obliteration. The women who had bilateral endometrioma had significantly lower levels of 25-hydroxy vitamin D compared to the women with unilateral endometrioma (8.4±2.7 ng/mL vs 11.1±5.6 ng/mL, p=0.047). Mean serum 25-hydroxy vitamin D levels in women with and without dysmenorrhea were not significantly different from each other in the endometriosis and non-endometriosis subgroups. Serum 25-hydroxy vitamin D had no correlation with dysmenorrhea-VAS scores (r=-0.157, p=0.267).Conclusion: The mean serum 25-hydroxy vitamin D levels were significantly decreased in both mild and moderate to severe endometriosis groups compared to the controls. The serum 25-hydroxy vitamin D levels had no correlation with the presence of infertility, deep infiltrating endometriosis, or Douglas pouch obliteration. The women who had bilateral endometrioma had significantly lower levels of 25-hydroxy vitamin D compared to the women with unilateral endometrioma.
      PubDate: 2021-08-02
      DOI: 10.21613/GORM.2019.949
      Issue No: Vol. 27, No. 2 (2021)
  • The Effect of Elevated Basal Follicle Stimulating Hormone Levels on
           Assisted Reproductive Technology Cycle Outcomes

    • Authors: Inci Kahyaoglu, Hatice Yilmaz Dogru, Sezin Erturk Aksakal, Iskender Kaplanoglu, Serdar Dilbaz, Leyla Mollamahmutoglu
      Pages: 138 - 142
      Abstract: OBJECTIVE: Despite the availability of better biomarkers, basal day 3 follicle-stimulating hormone is widely available and often used as the first-line test in ovarian reserve evaluation. The aim of this study was to evaluate the outcomes of cycles with elevated (>12 IU/mL) basal follicle-stimulating hormone values. STUDY DESIGN: Cycles with basal day 3 follicle-stimulating hormone values >12 IU/mL were divided into four cohorts according to follicle-stimulating hormone levels: group I, follicle-stimulating hormone between 12-15 IU/m, group II between 15-20 IU/mL, group III between 20-25 IU/mL and group IV >25 IU/mL. Both demographic characteristics and controlled ovarian stimulation parameters were retrospectively reviewed. RESULTS: Total antral follicle count was significantly higher in group I compared to the other three groups (p=0.001). Number of follicles ≥17 mm on human chorionic gonadotropin (hCG) day, number of retrieved oocytes, mature oocytes and fertilized oocytes were significantly higher in group I compared to the other groups (p=0.003, p=0.001, p=0.001, and p=0.001, respectively). No significant difference was found between groups regarding cancellation rates. The rate of embryo transfer per started cycle was significantly higher in group I compared to group III and group IV (p=0.001). Clinical pregnancy rates per embryo transfer were comparable among the groups.CONCLUSION: Despite the retrieval of lower quantities of oocytes, reasonable pregnancy rates could be achieved if embryo transfer was performed in cycles with follicle-stimulating hormone values over 12 IU/mL.
      PubDate: 2021-08-02
      DOI: 10.21613/GORM.2019.998
      Issue No: Vol. 27, No. 2 (2021)
  • Comparison of hCG Versus Gonadotropin-Releasing Hormone Agonist to Induce
           Oocyte Maturation in Assisted Reproductive Technology Cycles: A
           Retrospective Cohort Study

    • Authors: Gulay Beydilli Nacak, Elif Tozkir, Enis Ozkaya, Ebru Cogendez, Fatih Kaya
      Pages: 143 - 149
      Abstract: OBJECTIVE: To compare some cycle characteristics and outcomes using a protocol consisting of a GnRH agonist trigger or hCG trigger after cotreatment with GnRH antagonist.STUDY DESIGN: Thirty-three patients under 35 years of age with polycystic ovarian syndrome, polycystic ovarian morphology, or previous high response who underwent ovulation trigger by GnRH agonist trigger and 132 patients under 35 years of age with the polycystic ovarian syndrome, polycystic ovarian morphology, or previous high response who underwent ovulation trigger by hCG for IVF treatment. Patients were non-randomly assigned to an ovarian stimulation protocol consisting of either GnRH agonist trigger after cotreatment with GnRH antagonist (study group) or hCG trigger after antagonist protocol (control group).RESULTS: The positive pregnancy test was obtained in 70 women in the control group whereas in 13 cases in the study group (p=0.161). No case in the study group needed hospitalization whereas there were 15 cases in the control group who were required to be hospitalized due to ovarian hyperstimulation related symptoms (p=0.04).CONCLUSIONS: The use of a protocol consisting of a GnRH agonist trigger after GnRH antagonist cotreatment and freeze-all strategy reduces the risk of ovarian hyperstimulation syndrome in high-risk patients undergoing IVF without affecting pregnancy rates.
      PubDate: 2021-08-02
      DOI: 10.21613/GORM.2020.1034
      Issue No: Vol. 27, No. 2 (2021)
  • Association of Bacterial Vaginosis and Skin Disorders in Patients with
           Autoimmune Antibody Positivity

    • Authors: Burcu Beksac, Hanife Guler Donmez
      Pages: 150 - 153
      Abstract: OBJECTIVE: To investigate the association of bacterial vaginosis and skin disorders in patients with autoimmune antibody positivity.
      STUDY DESIGN: This retrospective study consisted of 80 patients with autoimmune antibody positivity. All patients were evaluated for the presence of bacterial vaginosis and skin disorders. Cervicovaginal smears were used for the definitive diagnosis of bacterial vaginosis. RESULT: We found bacterial vaginosis in 13.75% (11/80) of the cases. 1 (9.1%) and 10 (90.9%) cases had skin disorders in bacterial vaginosis positive and negative groups respectively (p=0.531). CONCLUSION: There is no relationship between bacterial vaginosis and the presence of skin disorders in patients with autoimmune antibody positivity.
      PubDate: 2021-08-02
      DOI: 10.21613/GORM.2020.1103
      Issue No: Vol. 27, No. 2 (2021)
  • Psychometric Properties of the Turkish Version of Prolapse and
           Incontinence Knowledge Questionnaire

    • Authors: Arife Korkut, Ilkim Citak Karakaya, Semiha Yenisehir, Mehmet Gurhan Karakaya
      Pages: 154 - 162
      Abstract: OBJECTIVE: This study aimed to translate and culturally adapt the prolapse and incontinence knowledge questionnaire into Turkish, and to investigate the psychometric properties of the Turkish version prolapse and incontinence knowledge questionnaire.STUDY DESIGN: Psychometric properties of the Turkish version prolapse and incontinence knowledge questionnaire, which was developed according to standard scientific translation procedures, were analyzed on 206 volunteer women (31.79±8.79-year-old), after being tested for its comprehensibility and content validity. The participants were questioned about their physical and socio-demographic characteristics, obstetrical-gynecological histories and menstrual states, current medical complaints, and reasons for applying to the clinics. In addition to Turkish version prolapse and incontinence knowledge questionnaire, they completed the Turkish incontinence quiz, global pelvic floor bother questionnaire, pelvic floor distress inventory-20 and pelvic floor impact questionnaire. Retests were performed on 27 participants, after one week. Internal consistency, test-retest reliability, and construct validity of the Turkish version prolapse and incontinence knowledge questionnaire were investigated. RESULTS: Internal consistencies of the Turkish version prolapse and incontinence knowledge questionnaire subscales (Turkish version prolapse and incontinence knowledge questionnaire-UI and Turkish version prolapse and incontinence knowledge questionnaire-pelvic organ prolapse) were high (Cronbach α=0.754 for both); item-total correlations were 0.127-0.576 and 0.217-0.509, respectively. Also, test-retest reliabilities of the subscales and the overall scale were high (Intraclass correlation coefficient =0.949, 0.911 and 0.878, respectively). Turkish version prolapse and Incontinence knowledge questionnaire scores were highly correlated with incontinence quiz scores and weakly correlated with pelvic floor distress inventory-20 and pelvic floor impact questionnaire-7 scores (p<0.05).CONCLUSION: It was concluded that Turkish version prolapse and incontinence knowledge questionnaire is a reliable and valid tool to measure Turkish women’s knowledge and awareness about urinary incontinence and pelvic organ prolapse.
      PubDate: 2021-08-02
      DOI: 10.21613/GORM.2020.1099
      Issue No: Vol. 27, No. 2 (2021)
  • Evaluation of the Results of Patients Who Were Treated with Laparoscopic
           Simple Tunnel Hysterosacropexy Method to Prevent Uterine Prolapse: A New

    • Authors: Erdal Seker, Evindar Elci
      Pages: 163 - 168
      Abstract: OBJECTIVES: To evaluate the results of patients with uterine prolapse who underwent laparoscopic simple tunnel hysterosacropexy as uterine protective surgery. In this surgical procedure, the parietal peritoneum which was cut off in traditional surgery is preserved. STUDY DESIGN: Data from women with apical prolapse of stage 2 or higher who underwent laparoscopic simple tunnel hysterosacropexy between October 1, 2017, and March 31, 2019, at the University of Health Sciences Diyarbakır Gazi Yasargil Education and Research Hospital, Diyarbakır, Turkey was retrospectively assessed. Patients were treated with laparoscopic simple tunnel hysterosacropexy; the meshes were anchored to the posterior cervical area, even in the presence of advanced multi-compartment vaginal prolapse. Data on the prolapse stage and urogenital functions were collected through clinical examinations, questionnaires at baseline, and 6 months after the operation. Results were analyzed using Wilcoxon Signed Ranks Test and Based on positive ranks. Data are presented as mean, minimum, maximum or percentage according to variables. RESULT: Overall, 12 women were included in the analysis; the mean follow-up was 6 months. There were significant improvements in the complaints and POP-Q values of patients included in the study. There were not any complications during the intraoperative period and postoperative follow-ups. During the first six-month follow-up, there were not any recurrence of prolapse. The mean operative time was 146 minutes; there were no intraoperative visceral or vascular injuries. There was no recurrence or vaginal erosion. CONCLUSION: In patients with stage 2 and more severe uterine prolapse, laparoscopic simple tunnel hysterosacropexy can be performed without cutting the peritoneum. Since the peritoneum is not cut during the surgery; intestinal injury prevalence and mesh exposure rates are lower.
      PubDate: 2021-08-02
      DOI: 10.21613/GORM.2020.1079
      Issue No: Vol. 27, No. 2 (2021)
  • A Prospective Study to Evaluate the Predictivity of Risk Malignancy Index
           in Adnexal Masses

    • Authors: Narin Yar Elmastas, Mehmet Obut, Senem Yaman Tunc
      Pages: 169 - 174
      Abstract: OBJECTIVE: To evaluate the efficiency of CA-125, menopausal status, ultrasound features and risk malignancy index in predicting malignancy in patients with an adnexal mass.STUDY DESIGN: This study was designed prospectively and 212 patients who applied to our hospital and met the study criteria were included. Preoperatively RMI value was calculated for the differentiation of benign from malignant patients. The diagnosis was confirmed by histopathology. Kolmogorov-Smirnov, Yates correction, Pearson Chi-Square and Student's t-test were used for statistical analysis. ROC curves were drawn as diagnostic tests and the test results were presented.RESULTS: Of 212 patients included in our study, 174 (82%) patients’ were reported as benign, 6 (3%) borderline and 32 (15%) malignant. In predicting malignancy, the malignity risk index with 200 cutoff value the sensitivity and specivity was 87% and 80% respectively. However, when the cutoff value of malignity risk index taken as 112, the sensitivity was unchanged but the specificity increased to 90%. Similarly, when CA-125's cutoff value was taken as 46U/mL, the sensitivity did not change but the specificity increased from 68% to 72%.CONCLUSION: Malignancy risk index is a method that has high sensitivity and specificity. Preoperative-op RMI calculation can provide accurate predictions for the establishment of an appropriate surgical plan for pelvic masses or referral to tertiary centers.
      PubDate: 2021-08-02
      DOI: 10.21613/GORM.2020.1057
      Issue No: Vol. 27, No. 2 (2021)
  • Should Echocardiographic Evaluation Be Performed Routinely in the First 72
           Hours in Extremely Low Birth Weight Babies'

    • Authors: Ruya Colak, Senem Alkan Ozdemir, Ezgi Yangin Ergon, Ferit Kulali, Oguz Han Kalkanli, Tulin Gokmen Yildirim, Murat Muhtar Yilmazer, Cuneyt Zihni, Sebnem Calkavur
      Pages: 175 - 180
      Abstract: Objective: Hemodynamically significant patent ductus arteriosus(hsPDA) is resulting in severe mortality and morbidity in infants with extremely low birth weight(ELBW). In our study, we aimed to evaluate the necessity of performing routine echocardiography(ECHO) in the first 72hours in ELBW infants.Study Design:This study was planned retrospectively and observationally.Between June2016 and December2018,36 patients diagnosed with hemodynamically significant PDA(hsPDA) who were hospitalized in the neonatal intensive care unit(NICU),with ≤28Gw or ≤1000g were included in this study.These babies were routinely performed ECHO for PDA between 24-72hours,although they were asymptomatic in the period from June2016 to December2017(n:23).Between January2018 and December2018, patients without PDA symptoms were expected to complete 72hours for routine PDA screening (n:13).The patients were divided into 2 groups as early ECHO group(EEG)(n=23) and late ECHO group (LEG)(n=13).In the presence of at least one of the clinical signs of systemic hypoperfusion and/or pulmonary hyperperfusion, symptomatic PDA was accepted and closure treatment was applied with ibuprofen(n: 23) or paracetamol(n: 5).While the two groups were compared in terms of demographic features,ECHO findings,and the state of taking closure therapy,patients receiving closure therapy were compared in terms of mortality and premature morbidity.Results:The average birth weight of 36 patients was 855.9(± 241.5)g, and the average week of birth was 26.4(± 2.1)Gw.It was observed that the two groups were similar in terms of demographic characteristics.Although the findings of ECHO and treatment rates were similar between the two groups,it was observed that the EEG had earlier closure treatment(p = 0.03). In patients receiving closure treatment, performing early(n:17)and late(n:11) echocardiography showed no statistical difference in the long-term results.Conclusion:Performing early ECHO without symptoms in infants with ELBW may provoke the clinician to give PDA closure treatment earlier. In infants with ELBW,unnecessary closure treatment can be prevented by closely monitoring the symptoms of PDA and performing ECHO when necessary.
      PubDate: 2021-08-02
      DOI: 10.21613/GORM.2021.1168
      Issue No: Vol. 27, No. 2 (2021)
  • Primary Anterior Abdominal Wall Leiomyoma - a Rare Case with a Common

    • Authors: Muhammad Izzuddin Hamzan, Ariffuddin Ishak, Normala Basiron
      Pages: 181 - 183
      Abstract: Extra-peritoneal leiomyoma is a rare condition with the recognised etiologic factor being direct seeding of the site by a prior uterine surgery with a right metabolic environment. We report a rare case of abdominal wall leiomyoma developing in a fertile woman with no known predisposing factor and highlight the common approach to establish the diagnosis so as to deliver appropriate treatment to the patient.
      PubDate: 2021-08-02
      DOI: 10.21613/GORM.2018.914
      Issue No: Vol. 27, No. 2 (2021)
  • Jejunal Fistula Complicating Ovarian Serous Carcinoma: Case Report of a
           Rare Phenomenon and Review of the Literature

    • Authors: Isin Ureyen, Tayfun Toptas, Sezin Ates Tatar, Gulsum Ekin, Faruk Gulec, Aysel Uysal
      Pages: 184 - 186
      Abstract: Invasion of the wall of the digestive system by ovarian cancer cells isn’t so rare. On the other hand, fistula formation between the tumor and digestive system is an uncommon status. We described a patient with ovarian serous carcinoma that was fistulized into jejenum and formed a region composed of stool and tumor surrounded and limited by small intestines recognized during surgery. This diagnosis should be kept in mind while preparing a patient for ovarian cancer surgery if the patient has acute abdomen or abdominal pain incompatible with the extent of the tumor.
      PubDate: 2021-08-02
      DOI: 10.21613/GORM.2018.816
      Issue No: Vol. 27, No. 2 (2021)
  • Effects Of Hormonal Supplements In Women with Poor Ovarian Response
           Undergoing Assisted Reproductive Technology

    • Authors: Silan Melis Bozan, Gurkan Bozdag
      Pages: 187 - 190
      Abstract: Poor ovarian response remains one of the major challenges of assisted reproductive technology. Over the years, various interventions have been proposed to improve reproductive outcomes in poor responders, yet few have been shown to be beneficial. Recent studies indicate that hormonal pretreatments might increase clinical pregnancy rate, live birth rate and the number of oocytes retrieved in women with poor ovarian response undergoing assisted reproductive technology. Areas covered: Following extensive research of the up to date literature, this review aims to cover current considerations and controversies regarding the use of hormonal supplements such as dehydroepiandrosterone, transdermal testosterone and growth hormone. Expert opinion: There is limited data for the validity of using growth hormone and androgens or androgen modulating agents during assisted reproductive technology cycles in women suffering from poor ovarian response. However, there is a need to support the available data with further randomized controlled trials seeking for live birth rate as the primary outcome.
      PubDate: 2021-08-02
      DOI: 10.21613/GORM.2019.923
      Issue No: Vol. 27, No. 2 (2021)
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