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J. of Applied Pharmaceutical Research     Open Access   (Followers: 1)
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Journal of Applied Pharmaceutical Research
Number of Followers: 1  

  This is an Open Access Journal Open Access journal
ISSN (Online) 2348-0335
Published by Creative Pharma Assent Homepage  [1 journal]
  • New treatment approaches for the management of Alzheimer's disease

    • Authors: Abhishek; Sourav Pahwa
      Abstract: This assessment is mainly concerned with the new treatment approaches for the management of Alzheimer’s disease and how these procedures can be beneficial for patients suffering from such diseases. With various other brain diseases, the number of Alzheimer’s disease cases is also increasing day by day in the world. So, it has become very important to be aware of the various new methods for the treatment of Alzheimer’s disease. The new treatment methods that are been used for the treatment of such brain disorders are found to be highly beneficial, as various new therapies and methods are being discovered for the treatment of such brain diseases. The various medications that are being used for the treatment of such diseases are beneficial only when taken under proper guidance and amount. Various precautions are very necessary during the treatment of such diseases, which can be helpful in the treatment. These treatment procedures may vary from person to person depending on their age factor and health.
      PubDate: Thu, 30 Jun 2022 00:00:00 +053
       
  • Thysanolaena maxima (roxb.) kuntze: a therapeutically less explored plant
           from northeastern India

    • Authors: Safal Sharma; Bibhas Pandit, Sushilta Pradhan, J P Mohanty
      Abstract: Thysanolaena maxima is a member of the Poaceae family of medicinal plants, and it is used to cure a variety of ailments, including boils, vomiting, stomach disorders, and infectious diseases like tuberculosis. Thysanolaena maxima has been found to possess a variety of chemicals, including terpenoids, polysaccharides, tannins, flavonoids, saponins, glycosides, phenols, and steroids. The current mini-review analyses its pharmacological profile, chemical components, and phytochemistry, with an emphasis on, cytotoxic, antioxidant and antimicrobial properties, in order to better assess the plant's medicinal potential. Traditional and modern medicine, as well as possible herbal therapy for a number of ailments, have a lot of potential for Thysanolaena maxima. Its active ingredients and pharmacological activities is yet to be thoroughly researched. This brief review has offered up-to-date work on Thysanolaena maxima's phtyochemical and other information, which will serve as a reference for future research
      PubDate: Thu, 30 Jun 2022 00:00:00 +053
       
  • A study on cost analysis of oral antihypertensive drugs available in India

    • Authors: Avanthi E; Allen Joe Rodrigues, Abhishek Achar, Mahesh G K; Anand Koppal
      Abstract: The major health care problem in developing world is shifting from communicable diseases to non-communicable disease which causes morbidities more than mortality affecting the personal efficiency. Hypertension is a major health care burden in developing countries like India causing both morbidity and mortality. Few studies shows that the hypertension prevalence has raised from 2% to 15% in rural population and 2% to 25% in urban population in last six decades in India. This research work aims to enumerate the price of commonly available oral antihypertensive drugs in India. It also aims to study the cost variation of oral antihypertensive drugs. The present study was carried out in the department of Pharmacology in a tertiary care medical college in south India. The cost analysis of individual drugs by different manufacturers were done. Percentage of cost variation was analysed. The variation in cost of most of the antihypertensive drugs is more than 100%. It’s found maximum in Amlodipine (5mg) with cost variation of 625%, Atenolol 100 mg with cost variation of 413%. In India there is a wide price variation among antihypertensive drugs. The major gap in the cost variation of antihypertensive drugs to be narrowed for the benefit of the patients. So the government and the prescribing doctors should think about the huge difference in cost and work in the direction of benefitting the patient.
      PubDate: Thu, 30 Jun 2022 00:00:00 +053
       
  • Development and validation of UV-spectrophotometric method for the
           determination of folic acid in bulk and tablet dosage forms

    • Authors: Takreem A. Elkhazein; Tahani A. Abdeljabar, Amal N. Abdelrahman, Mohamed E. Adam, Shaza W. Shantier
      Abstract: The purpose of this study was to create and verify a simple and accurate UV-Spectrophotometric technique for determining Folic acid in bulk and tablet dosage form. The approach was based on the measurement of folic acid solution absorbance at 255nm in 0.01M NaOH. In the concentration range of 10-50 g/ml, the constructed calibration curve was found to be linear (R2 = 0.9996). Limits of detection and quantification were 2.73 µg/ml, and 8.27 µg/ml, respectively. The precision of the developed method was confirmed by the obtained low RSD% values. Recoveries percentages were found 98.46%±1.42, 100.0%±0.20, 98.92%±1.12; n=3 for 50%, 100% and 150% levels, respectively indicating the method accuracy and freedom of interference from excipients. Folic acid content percent in the two analyzed brands were found to be equal 96.59%±0.005; n=3, and 97.28%±0.003; n=3 which complies with the official range (90-110%).
      PubDate: Thu, 30 Jun 2022 00:00:00 +053
       
  • Formulation and evaluation of theophylline sustained release matrix
           tablets using synthetic polymers

    • Authors: Navdeep Kaur; Mohit Kumar
      Abstract: The aim of present work was to develop theophylline sustained release tablets which could improve patient compliance towards the effective management of asthma The polymers, HPMC (Hydroxy propyl methyl cellulose) K4M, HPMC K100M, Eudragit, Chitosan in blending and granulation stage of processing and evaluate their physico-chemical properties. The precompression limits of the powder blends used for the preparation of sustained-release tablets were in an acceptable range of pharmacopeial specification with excellent flow and good compressibility. Wet granulation method prepared tablets using different grades of polymers HPMC K100, HPMC K4M, Eudragit, Chitosan. The active ingredient, release retardants, diluents, fraction of polymer are mixed to make wet mass for granulation. The in- vitro release was prolonged to 12 hours using HPMC K4M, HPMC K100M, Chitosan, Eudragit. F9 formulation prolonged the theophylline release in 12 hours. The effect of polymer on drug release was studied. Thus, sustained release matrix tablets can promise better patient compliance through reduction in over-all dose and dosage regimen, which can be of excessive support to treat chronic disease.
      PubDate: Thu, 30 Jun 2022 00:00:00 +053
       
  • Perioperative anaesthetic challenges in coronavirus disease associated
           mucormycosis: A retrospective study

    • Authors: Mamta Khandelwal; Sunita Meena, Sanjay Morwal, Priyanka Jain, Yogesh Modi
      Abstract: Background & Aim: Mucormycosis is a life-threatening fungal infection that occurs in immune-compromised patients. There were large number of mucormycosis cases reported during COVID pandemic (2019-21) mainly as post COVID sequelae. In the present retrospective study we aimed to evaluate the perioperative challenges faced in the anaesthetic management of Coronavirus disease associated Mucormycosis (CAM) patients who underwent surgery under general anesthesia. Methods: The perioperative records of CAM patients who underwent surgery from May 2021-July 2021 for mucormycosis were reviewed and evaluated in terms of difficult bag mask ventilation, difficult intubation and other intraoperative and post-operative complications. Observation and Results: The incidence of CAM and its associated surgery was significantly more in males than females and the mean age of the patients was 50 years. In 39.8% patients we encountered difficult bag mask ventilation. and in 17.5% patients more than two attempts for intubation were required. Conclusion: Mucormycosis patients posted for surgery may pose various anesthetic challenges especially in airway management and anesthesiologists must be well prepared for it
      PubDate: Thu, 30 Jun 2022 00:00:00 +053
       
 
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