Publisher: Ternopil State Medical University   (Total: 5 journals)   [Sort by number of followers]

Showing 1 - 5 of 5 Journals sorted alphabetically
Clinical Dentistry     Open Access   (Followers: 3)
Intl. J. of Medicine and Medical Research     Open Access   (Followers: 1)
Medical Informatics and Engineering     Open Access   (Followers: 1)
Медична освіта     Open Access  
Фармацевтичний часопис     Open Access  
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Medical Informatics and Engineering
Number of Followers: 1  

  This is an Open Access Journal Open Access journal
ISSN (Print) 1996-1960 - ISSN (Online) 1997-7468
Published by Ternopil State Medical University Homepage  [5 journals]
  • SYSTEMIC BIOMEDICINE AS THE BASIS OF PERSONALIZED AND PRECISION MEDICINE

    • Authors: O. P. Mintser, L. Yu. Babintseva, S. I. Mokhnachov, O. O. Sukhanova
      Abstract: Background. The issue of determining the role of systemic biomedicine in achieving the goal of personalized medicine is considered. It was found that in various studies the concept of personalized medicine has names: precision, targeted, individualized and personalized medicine. In our study, the listed concepts are considered as synonyms. Materials and methods. A theoretical analysis and generalization of information about the role of systemic biomedicine in achieving the goal of personalized medicine was carried out. The research results are systematized according to databases of scientific periodicals: PubMed, Web of Science, Scopus, ScienceDirect, etc. Classical methods of information search and processing were used at various stages of the research. Results. It is noted that the use of principles and methods of systemic biomedicine provides new opportunities in the study of chronic multifactorial human diseases. Modern developments in the field of machine learning (with an emphasis on deep learning) may allow in the future to perform the process of personalized diagnosis of early metabolic disorders in the clinic. Conclusions. It is necessary to solve the issues of identifying the choice of a solution in personalized medicine, classifying the risks of a similar strategy, mathematical methods of comparing possible approaches.
      PubDate: 2023-10-09
      DOI: 10.11603/mie.1996-1960.2023.1-2.13963
       
  • INFORMATIONAL ASPECTS OF QUANTITATIVE ASSESSMENT OF THE INDIVIDUAL MENTAL
           HEALTH

    • Authors: O. P. Mintser, A. M. Novyk
      Pages: 4 - 23
      Abstract: Background. Assessment of a person's mental health is probably the most important and most difficult component of determining the health of an individual and a population. The purpose of the work was to analyze the conceptual possibility of quantitative assessment of mental health and to determine the criterion of mental health of the individual and the population. Materials and methods. A theoretical analysis and generalization of information on the assessment of human mental health and determination of the criterion of mental health of an individual and the population was carried out. The research results were systematized using the following databases of scientific periodicals: Web of Science, PubMed, Scopus, ScienceDirect etc. Classical methods of information search were applied at various stages of the research. Results. Answering the question contained in the purpose of the study, one should express the opinion that at the current period of development of medicine, there is no method of integral assessment of mental health. Additional work is needed to study factors related to mental health and decision-making processes regarding the policy of assessment and strengthening of mental health. There is a need for reliable and reliable indicators of the state of mental health of the individual and the population, as well as for the substantiation of indicators to track the validity and fairness of the data. Conclusions. Most importantly - the creation of an integral quantitative criterion for assessing human mental health. The level of electronic research in the field of mental health is constantly increasing. This is due to the extremely rapid growth in the implementation of information technologies, including the Internet of Things, robotics, artificial intelligence, applied to the provision of psychiatric services.
      PubDate: 2023-10-09
      DOI: 10.11603/mie.1996-1960.2023.1-2.13958
       
  • ANALYSIS OF THE USE OF MODERN IN VIVO MICROSCOPY METHODS FOR THE DIAGNOSIS
           AND TREATMENT OF MALIGNANT NEOPLASMS

    • Authors: Ye. A. Kryuchуna, A. A. Kryuchyn
      Pages: 24 - 43
      Abstract: Background. In vivo endoscopic optical microscopy provides a tool to assess tissue architecture and morphology similar to standard histological examination without the need for tissue removal. Real-time in vivo imaging has become an integral tool for the investigation and understanding of cellular processes in health and disease at single-cell resolution, has revolutionized visualization of tumor-microenvironment interactions in real time. At the same time, there are still many unresolved questions regarding the clear interpretation of the results obtained with the intravital microscopy, indications for the clinical application of each of the technologies, the formation of clinical protocols with the inclusion of appropriate methods for different nosology, modification of surgical instruments with the involvement of optical systems, etc. Materials and methods. Theoretical analysis, generalization, and systematization of research results were carried out in accordance with PRISMA Group recommendations using such leading scientometric databases as PubMed, Medline, PILOTS Ovid EMBASE, Ovid Cochrane Central Register of Controlled Trials, Ovid Cochrane Database of Systematic Reviews, Ovid PsycINFO, Global Health Library CINAHL, and the Web of Science and Scopus, for the period from 2003 to 2023 by keywords: intravital microscopy, intravital multipho-ton microscopy, fluorescence confocal microscopy, photodynamic diagnostics, optical coherence tomography, confocal laser endomicroscopy, atomic force microscopy, computer image processing. Results. In this article, we focus on optical imaging technologies in vivo that have the powerful potential to significantly improve the diagnosis and therapy of malignant tumors: fluorescence confocal microscopy, optical coherence tomography, light sheet microscopy, two-photon and high-resolution microscopy, atomic force microscopy, electron microscopy, etc. We investigated the technological principles, preclinical and clinical studies analyzing the sensitivity and specificity of the above methods in the diagnosis and treatment of various types of malignant neoplasms, methods of computer image processing, discussed the prospects for improving the above technologies, further prospects for the development of the latest optical devices for the diagnosis and treatment of malignant neoplasms. We also address the advantages and limitations of this high-resolution technologies. Conclusions. Major technological advances are rapidly expanding the frontiers of intravital microscopy, which is likely to play an increasingly important role in preclinical, clinical cancer research, diagnosis and treatment of malignant neoplasms in the coming years.
      PubDate: 2023-10-09
      DOI: 10.11603/mie.1996-1960.2023.1-2.13956
       
  • INFORMATIVE EVALUATIONS OF THE VALUE OF THE O2/CO2 RATIO IN THE PHYSIOLOGY
           OF BREATHING

    • Authors: O. P. Mintser, V. S. Shchukin
      Pages: 44 - 56
      Abstract: Background. The article, based on the analysis of known facts related to the physiology of human breathing, suggests the existence of a new group of physiological constants related to the estimation of the О2/СО2 ratio during gas exchange. Considering this ratio as an important constant of homeostasis allows us to draw some conclusions that may be of practical importance. The aim of the study. Discussion of the possibility of recognizing the ratio О2/СО2 ~ 1 as a physiological constant of homeostasis of the human body, Materials and methods. Results. The article consists of three messages. In the first, the facts of the physiology of breathing are given, the meaning and contradictions of the respiratory coefficient and dead space are analyzed, and the necessary provisions of the physiology of breathing are considered. In the second message, the necessary provisions of gas analysis are given, and, finally, in the third, the possibility of extracting new physiological constants is analyzed. Conclusions. Preliminary conclusions have been drawn on the first report. 1. Between "taking into account (as a null hypothesis)" the fact of the existence of the ratio О2/СО2 ~ 1 and recognizing it as a constant of homeostasis, there is a long distance, on which the conclusions that logically and reasonably follow from the fact of recognizing the existence of a new physiological constant are "located". 2. Consideration of the use of the ratio pO2 ~ pCO2 can provide a new approach to a more complete understanding of the risk of chronic diseases, behavioral strategies to ensure a healthy lifestyle, in particular, understanding in which a person relies on fats, carbohydrates or proteins for energy, and for specialists - an idea about the physiology of gas exchange and the peculiarities of metabolism, which were not previously studied in the epidemiology of chronic diseases.
      PubDate: 2023-10-09
      DOI: 10.11603/mie.1996-1960.2023.1-2.13962
       
  • PRELIMINARY RESULTS OF THE APPLICATION OF COMPUTERIZED BREATHING CONTROL
           AS AN AUXILIARY METHOD OF PSYCHOLOGICAL REHABILITATION

    • Authors: A. V. Sharypanov, V. V. Vyshnevskyi, I. A. Chaikovsky, O. V. Syvak, L. A. Pukavska
      Pages: 57 - 69
      Abstract: Background. The urgency of conducting research of this type is due to the large number of people who need psychological rehabilitation as a result of the COVID-19 pandemic and the war in Ukraine. The goal of the work was to verify the effectiveness of automated breathing control technology application during consultations of psychologists with clients who had a high level of anxiety. Materials and methods. Results. Breathing techniques, including yogic ones, have long been known as having no contraindications for a physically healthy person. The effectiveness of breathing formulas, which are used during breathing exercises, for example for calming and relaxation, has been tested by time. The effectiveness of yogic breathing techniques is related to the ability of yogis to "hear their own pulse", which is achieved by long term trainings. The usefulness of binding such activity to the internal rhythms of a specific person is explained by the scientific directions of "chronobiology" and "chronomedicine". However, most people who could benefit from breathing exercises do not have time to learn to hear their own pulse because they need immediate help. In their work, psychologists teach clients the skills of stabilization and self-regulation, as well as their practical application in everyday life to quickly improve their psycho-emotional state thanks to the physiological characteristics of a person and without involving additional resources. Clients are encouraged to use abdominal breathing by square or 4-7-8 technique. Here, time intervals are measured in absolute units, such as seconds, steps, etc. Conclusions. The widespread use of mobile devices and low-cost wireless heart rate monitors has made it possible to implement automated technology for breathing control in which breathing formulas are personalized by pulse beats detected in real time. Preliminary results of a monitoring study in which computerized breathing control was implemented as an additional auxiliary method during psychological rehabilitation are presented.
      PubDate: 2023-10-09
      DOI: 10.11603/mie.1996-1960.2023.1-2.13952
       
  • DIGITAL DATA MANAGEMENT IN PATHOLOGY

    • Authors: L. Yu. Babintseva
      Pages: 70 - 79
      Abstract: Background. Digitalization processes are actively taking place in all spheres of human activity, associated with the saturation of the physical world with electronic and digital devices, means, systems and the establishment of electronic and communication interaction between them with the help of digital technologies. One of the information environments based on digital images of drugs is digital pathology. An overview of digital data management trends in modern pathology was made. The purpose of the study: to provide insight and summarize information about digital data management in pathology. Materials and methods. With the help of databases: Medline, Embase, PubMed, Web of Science, Cochrane Library, Cinahl etc., a theoretical analysis and generalization of information about modern digital data management in pathology, prospects for future research were carried out. Results. Large amounts of pathology data generated in clinical practice and in the course of scientific research make the task of improving the quality of their management urgent. Modern digital data management in pathology represents a technology aimed at providing personalized and targeted healthcare now and in the near future. Advances in medical information technologies are turning large volumes of multidimensional pathology data into useful information to drive the development and implementation of new approaches to diagnosis, treatment, and prevention of complex diseases. Conclusions. Trends in digital data management in pathology are related to the development of digitalization software and hardware, in particular image analysis tools, emulation of diagnostic procedures, management of large volumes of high-resolution images, as well as the implementation artificial intelligence.
      PubDate: 2023-10-09
      DOI: 10.11603/mie.1996-1960.2023.1-2.13960
       
  • DEVELOPMENT OF BIPOLAR ELECTRODE MODELS FOR EFFEC-TIVE HEAT DISTRIBUTION
           DURING RADIOFREQUENCY ABLATION OF VARICOSE VEINS

    • Authors: V. G. Solovyov, Yu. M. Lankin, I. Yu. Romanova
      Pages: 80 - 91
      Abstract: Background. The research is devoted to modeling the design of bipolar elec-trodes for effective heat distribution during radiofrequency ablation of varicose veins. Materials and methods. Mathematical modeling of the distribution of heat fields during vein ablation was carried out for three designs of ablators and the best in terms of the uniformity of the distribution of the heat field along the electrode was found. Results. Three variants of designs of bipolar electrodes for RFA are considered. The variant of the ablator with an electrode in the form of a bipolar wire winding with a rectangular section around the insulator is more acceptable from the point of view of the uniformity of the distribution of the thermal field along the electrode. Temperature control of biological tissue using data on the functional dependence of the specific conductivity of biological tissue on temperature can be applied only until structural changes in the tissue are achieved, after which the process of temperature control is complicated. If it is impossible to maintain the set temperature for the required time, the thermal capacity of the insulator can be used as an additional source of heat. To do this, after reaching the set temperature of the inner surface of the vein, the voltage is turned off, but the heat from the insulator and electrodes is transferred to the wall of the vein, which leads to heating of the inner surface of the vein and partial cooling of its outer surface. Conclusions. The maintenance of the given temperature distribution is decided by the selection of appropriate materials with the given coefficient of thermal conductivity and heat capacity, the choice of the value of the supply voltage and the geometrical parameters of the electrode. In the case of uneven distribution of the thermal field in the control zone and the appearance of areas with structural changes in the tissue, such areas can acquire unpredictable properties of the functional dependence of the specific conductivity of biological tissue on temperature. In such cases, the use of a stabilized voltage source can help, as the voltage will be redistributed between the areas, equalizing the heating and allowing to achieve positive results when heating the biological tissue.
      PubDate: 2023-10-09
      DOI: 10.11603/mie.1996-1960.2023.1-2.14007
       
  • EDUCATIONAL-SCIENTIFIC PROGRAM BY SPECIALTY 224 "TECHNOLOGIES OF MEDICAL
           DIAGNOSIS AND TREATMENT"

    • Authors: O. P. Mintser, T. M. Babkina, O. V. Shcherbina, S. V. Klymenko, V. V. Krasnov, P. O. Korol, L. I. Sergiienko
      Pages: 98 - 108
      Abstract: Background. The development of the health care industry is impossible without the use of modern technologies, which have recently become one of the decisive factors for ensuring high-quality and effective medical diagnosis and treatment of patients. Due to the involvement of information and communication and digital technologies, microelectronics, such directions as telemedicine, digital health care, mobile medicine, 3D printing (additive technologies) and others have emerged. At the same time, without laboratory and instrumental studies, it becomes impossible not only to make a clinical diagnosis, but also to control the safety of treatment. The doctor's decision-making about diagnosis, prevention and treatment of the patient depends on the level of reliability of the research. Material and methods. The development of the theory and practice of application of technologies of diagnostics and treatment of diseases of internal organs, including informational ones is analyzed by methods of expert assessment. Unified modern technologies of clinical laboratory and radiological research methods that help improve the quality of care; methods of radiation therapy that increase the effectiveness of treatment of cancer and non-cancer diseases, as well as methods of decision-making in the diagnosis, treatment and prognosis of the patient's condition. Results. A modern idea of the training program for future specialists of the degree of Doctor of Philosophy in the specialty 224 "Technologies of medical diagnosis and treatment" (according to the international classification 0914 "Medical diagnostic and treatment technology") of the branch of knowledge 22 "Health care" is presented. Upon completion of their studies, third-level higher education students must master general scientific (philosophical) competencies, acquire universal research skills and language competencies. The topics of the training courses are designed to promote the ability to integrate knowledge and solve complex problems in multidisciplinary and transdisciplinary contexts. Conclusion. The content of the proposed educational-scientific program in specialty 224 "Technologies of medical diagnostics and treatment" is aimed at training highly qualified and competitive specialists of the degree of Doctor of Philosophy, acquisition by them in the course of training of necessary theoretical knowledge and a complex of practical abilities, skills and competences to perform innovative research, also the implementation of the obtained results in practical health care.
      PubDate: 2023-10-09
      DOI: 10.11603/mie.1996-1960.2023.1-2.13964
       
  • EDUCATIONAL-SCIENTIFIC PROGRAM BY SPECIALTY 091 "BIOLOGY AND
           BIOCHEMISTRY"

    • Authors: L. Yu. Babintseva, N. G. Gorovenko, I.V. Dziublyk, D. L. Kyryk, S. O. Soloviov, S. V. Podolska, L. V. Vyunytska
      Pages: 109 - 119
      Abstract: Background. Biology of the 21st century is an interdisciplinary and transdisciplinary field of knowledge that is not only rapidly developing, but also requires proactive specialists integrated into the European and global scientific and educational space. Therefore, biology as a science of life is reflected in the development of many sciences and technologies of the modern world - from personalized medicine to the biological foundations of human psychology, from the development of new bionic materials and devices to cell engineering and artificial insemination. The modern vision of training future specialists of the degree of Doctor of Philosophy in the specialty 091 "Biology and Biochemistry" (according to the international codification 0511 Biology and 0512 Biochemistry) in the branch of knowledge 09 "Biology" is presented. Material and methods. Among the features of modern biology, we highlight: the study of the relationship between biological and social development of man; close connection with a number of high-tech areas, including molecular biology, molecular genetics, systems biomedicine. Practically all new trends and features are related to the use of information, communication and digital technologies. Results. Life is considered at different levels of its organization - from the molecule to the biosphere. For a deeper understanding of the biochemical principles of the functioning of cells in vivo and in vitro as the basis of modern biology, this year the boundaries of the specialty were expanded and a component was added -biological chemistry, the research of which covers several directions, in particular, static, dynamic and functional biochemistry. We note that new discoveries in the field of biochemistry significantly strengthen the level of modern world medicine, and generalizations of biochemistry help to illuminate the evolution of the organic world and the question of the origin of life on Earth. Upon completion of their studies, third-level higher education students must master general scientific (philosophical) competencies, acquire universal research skills and language competencies. The topics of the training courses are designed to promote the ability to integrate knowledge and solve complex problems in multidisciplinary and transdisciplinary contexts. Conclusion. The content of the proposed educational-scientific program in specialty 091 "Biology and Biochemistry" is aimed at training highly qualified and competitive specialists of the degree of Doctor of Philosophy, acquisition by them in the course of training of necessary theoretical knowledge and a complex of practical abilities, skills and competences to perform innovative research, also the implementation of the obtained results in practical health care.
      PubDate: 2023-10-09
      DOI: 10.11603/mie.1996-1960.2023.1-2.13965
       
 
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Publisher: Ternopil State Medical University   (Total: 5 journals)   [Sort by number of followers]

Showing 1 - 5 of 5 Journals sorted alphabetically
Clinical Dentistry     Open Access   (Followers: 3)
Intl. J. of Medicine and Medical Research     Open Access   (Followers: 1)
Medical Informatics and Engineering     Open Access   (Followers: 1)
Медична освіта     Open Access  
Фармацевтичний часопис     Open Access  
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JournalTOCs
School of Mathematical and Computer Sciences
Heriot-Watt University
Edinburgh, EH14 4AS, UK
Email: journaltocs@hw.ac.uk
Tel: +00 44 (0)131 4513762
 


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