Publisher: Smart Science and Technology LLC   (Total: 3 journals)

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Precision Medicine
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ISSN (Online) 2377-9888
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  • Diverging processes of symbiotic bacteria on vent mussels in the eastern
           Pacific Ocean

    • Authors: Phuong-Thao Ho; Yong-Jin Won
      Abstract: Chemoautolithotrophic bacteria thriving in deep-sea hydrothermal vents and cold seeps play an important role as primary producers in these remote, extreme ecosystems, and some of them have evolved symbiotic relationships with diverse marine invertebrate animals. These symbiotic bacteria harness energy through oxidation of reduced gases such as hydrogen sulfide, methane, hydrogen emissions, and eventually, their organic materials are transferred to their host invertebrates. Using symbiont-specific, multi-loci Next Generation Sequencing (NGS) data, geographical population genetics for symbiotic bacteria of Bathymodiolinae vent mussels were examined, with samples from nine vent localities. This is one of the most dominant and widespread taxa in global chemosynthetic environments on the sea floor, along the East Pacific Rise, Galápagos Rift, and the Pacific-Antarctic Ridge. The hope of this study is to gain insights into the evolution of bacteria in space and time. Particularly, the symbiotic bacteria of these Bathymodiolinae species have free-living and intracellular symbiotic stages, which allowed examination of their population dynamics and evolution in benthic environments. Per the results, it appears that two sister parapatric Bathymodiolinae species harbor the same symbiont species, thiotrophic Gamma-proteobacteria, regarding 16S rRNA encoding gene, but completely divergent lineages living in the north and south of the Easter Microplate regarding six protein-coding genes. Such divergence of bacteria seems to be initiated by orogeny of the Easter Microplate dated 2.5–5.3 million years ago, and equivalent to synonymous substitution rates of 0.77–1.62% per nucleotide per million years of protein-coding genes.
      PubDate: 2020-03-28
      Issue No: Vol. 3 (2020)
       
  • A new non-invasive tool for guiding H. pylori treatment

    • Authors: Erin Beckman; Ilaria Saracino, Giulia Fiorini, Courtney Clark, Vladimir Slepnev, Denise patel, clarissa gomez, Reddy Ponaka, Vecheslav Elagin, Berardino Vaira
      Abstract: Current guidelines recommend that all patients with documented H. pylori infection should be treated with an appropriate antibacterial therapy. Clarithromycin-based regimens are commonly used as a first line therapy in H. pylori positive patients, however soon after the introduction of clarithromycin-based therapies, treatment failures associated with resistance to clarithromycin were reported. In this study, we evaluated the feasibility of using a non-invasive sample type, stool, to detect the presence of H. pylori by molecular methods while concurrently detecting mutations associated with the resistance to clarithromycin. The sensitivity for H. pylori detection by PCR was 93.8% compared to composite reference methods with gastric tissue biopsy. Out of 213 true positives that were sequenced, 36.2% showed point mutations associated with CLA resistance (A2142C, A2142G, A2143G). The correlation of sequencing and PCR was 98%.  The correlation of sequencing and eradication of the infection was 86%.  The results of this test may be used as a tool for guiding treatment of H. pylori
      PubDate: 2020-03-28
      Issue No: Vol. 3 (2020)
       
 
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Publisher: Smart Science and Technology LLC   (Total: 3 journals)

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Heriot-Watt University
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Email: journaltocs@hw.ac.uk
Tel: +00 44 (0)131 4513762
 


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