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Publisher: Elsevier   (Total: 3044 journals)

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Showing 1 - 200 of 3044 Journals sorted alphabetically
AASRI Procedia     Open Access   (Followers: 15)
Academic Pediatrics     Hybrid Journal   (Followers: 22, SJR: 1.402, h-index: 51)
Academic Radiology     Hybrid Journal   (Followers: 21, SJR: 1.008, h-index: 75)
Accident Analysis & Prevention     Partially Free   (Followers: 84, SJR: 1.109, h-index: 94)
Accounting Forum     Hybrid Journal   (Followers: 23, SJR: 0.612, h-index: 27)
Accounting, Organizations and Society     Hybrid Journal   (Followers: 29, SJR: 2.515, h-index: 90)
Achievements in the Life Sciences     Open Access   (Followers: 4)
Acta Anaesthesiologica Taiwanica     Open Access   (Followers: 5, SJR: 0.338, h-index: 19)
Acta Astronautica     Hybrid Journal   (Followers: 343, SJR: 0.726, h-index: 43)
Acta Automatica Sinica     Full-text available via subscription   (Followers: 3)
Acta Biomaterialia     Hybrid Journal   (Followers: 25, SJR: 2.02, h-index: 104)
Acta Colombiana de Cuidado Intensivo     Full-text available via subscription   (Followers: 1)
Acta de Investigación Psicológica     Open Access   (Followers: 2)
Acta Ecologica Sinica     Open Access   (Followers: 8, SJR: 0.172, h-index: 29)
Acta Haematologica Polonica     Free   (SJR: 0.123, h-index: 8)
Acta Histochemica     Hybrid Journal   (Followers: 3, SJR: 0.604, h-index: 38)
Acta Materialia     Hybrid Journal   (Followers: 215, SJR: 3.683, h-index: 202)
Acta Mathematica Scientia     Full-text available via subscription   (Followers: 5, SJR: 0.615, h-index: 21)
Acta Mechanica Solida Sinica     Full-text available via subscription   (Followers: 9, SJR: 0.442, h-index: 21)
Acta Oecologica     Hybrid Journal   (Followers: 10, SJR: 0.915, h-index: 53)
Acta Otorrinolaringologica (English Edition)     Full-text available via subscription   (Followers: 1)
Acta Otorrinolaringológica Española     Full-text available via subscription   (Followers: 3, SJR: 0.311, h-index: 16)
Acta Pharmaceutica Sinica B     Open Access   (Followers: 2)
Acta Poética     Open Access   (Followers: 4)
Acta Psychologica     Hybrid Journal   (Followers: 23, SJR: 1.365, h-index: 73)
Acta Sociológica     Open Access  
Acta Tropica     Hybrid Journal   (Followers: 6, SJR: 1.059, h-index: 77)
Acta Urológica Portuguesa     Open Access  
Actas Dermo-Sifiliograficas     Full-text available via subscription   (Followers: 4)
Actas Dermo-Sifiliográficas (English Edition)     Full-text available via subscription   (Followers: 3)
Actas Urológicas Españolas     Full-text available via subscription   (Followers: 4, SJR: 0.383, h-index: 19)
Actas Urológicas Españolas (English Edition)     Full-text available via subscription   (Followers: 2)
Actualites Pharmaceutiques     Full-text available via subscription   (Followers: 5, SJR: 0.141, h-index: 3)
Actualites Pharmaceutiques Hospitalieres     Full-text available via subscription   (Followers: 4, SJR: 0.112, h-index: 2)
Acupuncture and Related Therapies     Hybrid Journal   (Followers: 3)
Acute Pain     Full-text available via subscription   (Followers: 13)
Ad Hoc Networks     Hybrid Journal   (Followers: 11, SJR: 0.967, h-index: 57)
Addictive Behaviors     Hybrid Journal   (Followers: 15, SJR: 1.514, h-index: 92)
Addictive Behaviors Reports     Open Access   (Followers: 5)
Additive Manufacturing     Hybrid Journal   (Followers: 7, SJR: 1.039, h-index: 5)
Additives for Polymers     Full-text available via subscription   (Followers: 21)
Advanced Drug Delivery Reviews     Hybrid Journal   (Followers: 134, SJR: 5.2, h-index: 222)
Advanced Engineering Informatics     Hybrid Journal   (Followers: 11, SJR: 1.265, h-index: 53)
Advanced Powder Technology     Hybrid Journal   (Followers: 17, SJR: 0.739, h-index: 33)
Advances in Accounting     Hybrid Journal   (Followers: 9, SJR: 0.299, h-index: 15)
Advances in Agronomy     Full-text available via subscription   (Followers: 15, SJR: 2.071, h-index: 82)
Advances in Anesthesia     Full-text available via subscription   (Followers: 25, SJR: 0.169, h-index: 4)
Advances in Antiviral Drug Design     Full-text available via subscription   (Followers: 3)
Advances in Applied Mathematics     Full-text available via subscription   (Followers: 6, SJR: 1.054, h-index: 35)
Advances in Applied Mechanics     Full-text available via subscription   (Followers: 10, SJR: 0.801, h-index: 26)
Advances in Applied Microbiology     Full-text available via subscription   (Followers: 22, SJR: 1.286, h-index: 49)
Advances In Atomic, Molecular, and Optical Physics     Full-text available via subscription   (Followers: 16, SJR: 3.31, h-index: 42)
Advances in Biological Regulation     Hybrid Journal   (Followers: 4, SJR: 2.277, h-index: 43)
Advances in Botanical Research     Full-text available via subscription   (Followers: 3, SJR: 0.619, h-index: 48)
Advances in Cancer Research     Full-text available via subscription   (Followers: 25, SJR: 2.215, h-index: 78)
Advances in Carbohydrate Chemistry and Biochemistry     Full-text available via subscription   (Followers: 9, SJR: 0.9, h-index: 30)
Advances in Catalysis     Full-text available via subscription   (Followers: 5, SJR: 2.139, h-index: 42)
Advances in Cellular and Molecular Biology of Membranes and Organelles     Full-text available via subscription   (Followers: 12)
Advances in Chemical Engineering     Full-text available via subscription   (Followers: 26, SJR: 0.183, h-index: 23)
Advances in Child Development and Behavior     Full-text available via subscription   (Followers: 10, SJR: 0.665, h-index: 29)
Advances in Chronic Kidney Disease     Full-text available via subscription   (Followers: 10, SJR: 1.268, h-index: 45)
Advances in Clinical Chemistry     Full-text available via subscription   (Followers: 28, SJR: 0.938, h-index: 33)
Advances in Colloid and Interface Science     Full-text available via subscription   (Followers: 18, SJR: 2.314, h-index: 130)
Advances in Computers     Full-text available via subscription   (Followers: 16, SJR: 0.223, h-index: 22)
Advances in Dermatology     Full-text available via subscription   (Followers: 12)
Advances in Developmental Biology     Full-text available via subscription   (Followers: 11)
Advances in Digestive Medicine     Open Access   (Followers: 5)
Advances in DNA Sequence-Specific Agents     Full-text available via subscription   (Followers: 5)
Advances in Drug Research     Full-text available via subscription   (Followers: 22)
Advances in Ecological Research     Full-text available via subscription   (Followers: 41, SJR: 3.25, h-index: 43)
Advances in Engineering Software     Hybrid Journal   (Followers: 25, SJR: 0.486, h-index: 10)
Advances in Experimental Biology     Full-text available via subscription   (Followers: 7)
Advances in Experimental Social Psychology     Full-text available via subscription   (Followers: 40, SJR: 5.465, h-index: 64)
Advances in Exploration Geophysics     Full-text available via subscription   (Followers: 3)
Advances in Food and Nutrition Research     Full-text available via subscription   (Followers: 48, SJR: 0.674, h-index: 38)
Advances in Fuel Cells     Full-text available via subscription   (Followers: 15)
Advances in Genetics     Full-text available via subscription   (Followers: 15, SJR: 2.558, h-index: 54)
Advances in Genome Biology     Full-text available via subscription   (Followers: 11)
Advances in Geophysics     Full-text available via subscription   (Followers: 6, SJR: 2.325, h-index: 20)
Advances in Heat Transfer     Full-text available via subscription   (Followers: 21, SJR: 0.906, h-index: 24)
Advances in Heterocyclic Chemistry     Full-text available via subscription   (Followers: 8, SJR: 0.497, h-index: 31)
Advances in Imaging and Electron Physics     Full-text available via subscription   (Followers: 2, SJR: 0.396, h-index: 27)
Advances in Immunology     Full-text available via subscription   (Followers: 35, SJR: 4.152, h-index: 85)
Advances in Inorganic Chemistry     Full-text available via subscription   (Followers: 9, SJR: 1.132, h-index: 42)
Advances in Insect Physiology     Full-text available via subscription   (Followers: 3, SJR: 1.274, h-index: 27)
Advances in Integrative Medicine     Hybrid Journal   (Followers: 6)
Advances in Life Course Research     Hybrid Journal   (Followers: 8, SJR: 0.764, h-index: 15)
Advances in Lipobiology     Full-text available via subscription   (Followers: 2)
Advances in Magnetic and Optical Resonance     Full-text available via subscription   (Followers: 9)
Advances in Marine Biology     Full-text available via subscription   (Followers: 15, SJR: 1.645, h-index: 45)
Advances in Mathematics     Full-text available via subscription   (Followers: 10, SJR: 3.261, h-index: 65)
Advances in Medical Sciences     Hybrid Journal   (Followers: 6, SJR: 0.489, h-index: 25)
Advances in Medicinal Chemistry     Full-text available via subscription   (Followers: 5)
Advances in Microbial Physiology     Full-text available via subscription   (Followers: 4, SJR: 1.44, h-index: 51)
Advances in Molecular and Cell Biology     Full-text available via subscription   (Followers: 22)
Advances in Molecular and Cellular Endocrinology     Full-text available via subscription   (Followers: 10)
Advances in Molecular Toxicology     Full-text available via subscription   (Followers: 7, SJR: 0.324, h-index: 8)
Advances in Nanoporous Materials     Full-text available via subscription   (Followers: 4)
Advances in Oncobiology     Full-text available via subscription   (Followers: 3)
Advances in Organometallic Chemistry     Full-text available via subscription   (Followers: 15, SJR: 2.885, h-index: 45)
Advances in Parallel Computing     Full-text available via subscription   (Followers: 7, SJR: 0.148, h-index: 11)
Advances in Parasitology     Full-text available via subscription   (Followers: 7, SJR: 2.37, h-index: 73)
Advances in Pediatrics     Full-text available via subscription   (Followers: 24, SJR: 0.4, h-index: 28)
Advances in Pharmaceutical Sciences     Full-text available via subscription   (Followers: 13)
Advances in Pharmacology     Full-text available via subscription   (Followers: 15, SJR: 1.718, h-index: 58)
Advances in Physical Organic Chemistry     Full-text available via subscription   (Followers: 7, SJR: 0.384, h-index: 26)
Advances in Phytomedicine     Full-text available via subscription  
Advances in Planar Lipid Bilayers and Liposomes     Full-text available via subscription   (Followers: 3, SJR: 0.248, h-index: 11)
Advances in Plant Biochemistry and Molecular Biology     Full-text available via subscription   (Followers: 8)
Advances in Plant Pathology     Full-text available via subscription   (Followers: 5)
Advances in Porous Media     Full-text available via subscription   (Followers: 4)
Advances in Protein Chemistry     Full-text available via subscription   (Followers: 18)
Advances in Protein Chemistry and Structural Biology     Full-text available via subscription   (Followers: 19, SJR: 1.5, h-index: 62)
Advances in Psychology     Full-text available via subscription   (Followers: 61)
Advances in Quantum Chemistry     Full-text available via subscription   (Followers: 5, SJR: 0.478, h-index: 32)
Advances in Radiation Oncology     Open Access  
Advances in Small Animal Medicine and Surgery     Hybrid Journal   (Followers: 2, SJR: 0.1, h-index: 2)
Advances in Space Research     Full-text available via subscription   (Followers: 348, SJR: 0.606, h-index: 65)
Advances in Structural Biology     Full-text available via subscription   (Followers: 8)
Advances in Surgery     Full-text available via subscription   (Followers: 7, SJR: 0.823, h-index: 27)
Advances in the Study of Behavior     Full-text available via subscription   (Followers: 30, SJR: 1.321, h-index: 56)
Advances in Veterinary Medicine     Full-text available via subscription   (Followers: 16)
Advances in Veterinary Science and Comparative Medicine     Full-text available via subscription   (Followers: 13)
Advances in Virus Research     Full-text available via subscription   (Followers: 5, SJR: 1.878, h-index: 68)
Advances in Water Resources     Hybrid Journal   (Followers: 43, SJR: 2.408, h-index: 94)
Aeolian Research     Hybrid Journal   (Followers: 5, SJR: 0.973, h-index: 22)
Aerospace Science and Technology     Hybrid Journal   (Followers: 318, SJR: 0.816, h-index: 49)
AEU - Intl. J. of Electronics and Communications     Hybrid Journal   (Followers: 8, SJR: 0.318, h-index: 36)
African J. of Emergency Medicine     Open Access   (Followers: 5, SJR: 0.344, h-index: 6)
Ageing Research Reviews     Hybrid Journal   (Followers: 8, SJR: 3.289, h-index: 78)
Aggression and Violent Behavior     Hybrid Journal   (Followers: 408, SJR: 1.385, h-index: 72)
Agri Gene     Hybrid Journal  
Agricultural and Forest Meteorology     Hybrid Journal   (Followers: 15, SJR: 2.18, h-index: 116)
Agricultural Systems     Hybrid Journal   (Followers: 30, SJR: 1.275, h-index: 74)
Agricultural Water Management     Hybrid Journal   (Followers: 39, SJR: 1.546, h-index: 79)
Agriculture and Agricultural Science Procedia     Open Access  
Agriculture and Natural Resources     Open Access   (Followers: 1)
Agriculture, Ecosystems & Environment     Hybrid Journal   (Followers: 54, SJR: 1.879, h-index: 120)
Ain Shams Engineering J.     Open Access   (Followers: 5, SJR: 0.434, h-index: 14)
Air Medical J.     Hybrid Journal   (Followers: 5, SJR: 0.234, h-index: 18)
AKCE Intl. J. of Graphs and Combinatorics     Open Access   (SJR: 0.285, h-index: 3)
Alcohol     Hybrid Journal   (Followers: 9, SJR: 0.922, h-index: 66)
Alcoholism and Drug Addiction     Open Access   (Followers: 8)
Alergologia Polska : Polish J. of Allergology     Full-text available via subscription   (Followers: 1)
Alexandria Engineering J.     Open Access   (Followers: 1, SJR: 0.436, h-index: 12)
Alexandria J. of Medicine     Open Access  
Algal Research     Partially Free   (Followers: 8, SJR: 2.05, h-index: 20)
Alkaloids: Chemical and Biological Perspectives     Full-text available via subscription   (Followers: 3)
Allergologia et Immunopathologia     Full-text available via subscription   (Followers: 1, SJR: 0.46, h-index: 29)
Allergology Intl.     Open Access   (Followers: 4, SJR: 0.776, h-index: 35)
Alpha Omegan     Full-text available via subscription   (SJR: 0.121, h-index: 9)
ALTER - European J. of Disability Research / Revue Européenne de Recherche sur le Handicap     Full-text available via subscription   (Followers: 8, SJR: 0.158, h-index: 9)
Alzheimer's & Dementia     Hybrid Journal   (Followers: 47, SJR: 4.289, h-index: 64)
Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring     Open Access   (Followers: 5)
Alzheimer's & Dementia: Translational Research & Clinical Interventions     Open Access   (Followers: 3)
American Heart J.     Hybrid Journal   (Followers: 48, SJR: 3.157, h-index: 153)
American J. of Cardiology     Hybrid Journal   (Followers: 45, SJR: 2.063, h-index: 186)
American J. of Emergency Medicine     Hybrid Journal   (Followers: 39, SJR: 0.574, h-index: 65)
American J. of Geriatric Pharmacotherapy     Full-text available via subscription   (Followers: 6, SJR: 1.091, h-index: 45)
American J. of Geriatric Psychiatry     Hybrid Journal   (Followers: 16, SJR: 1.653, h-index: 93)
American J. of Human Genetics     Hybrid Journal   (Followers: 31, SJR: 8.769, h-index: 256)
American J. of Infection Control     Hybrid Journal   (Followers: 24, SJR: 1.259, h-index: 81)
American J. of Kidney Diseases     Hybrid Journal   (Followers: 32, SJR: 2.313, h-index: 172)
American J. of Medicine     Hybrid Journal   (Followers: 46, SJR: 2.023, h-index: 189)
American J. of Medicine Supplements     Full-text available via subscription   (Followers: 3)
American J. of Obstetrics and Gynecology     Hybrid Journal   (Followers: 193, SJR: 2.255, h-index: 171)
American J. of Ophthalmology     Hybrid Journal   (Followers: 56, SJR: 2.803, h-index: 148)
American J. of Ophthalmology Case Reports     Open Access   (Followers: 4)
American J. of Orthodontics and Dentofacial Orthopedics     Full-text available via subscription   (Followers: 6, SJR: 1.249, h-index: 88)
American J. of Otolaryngology     Hybrid Journal   (Followers: 24, SJR: 0.59, h-index: 45)
American J. of Pathology     Hybrid Journal   (Followers: 26, SJR: 2.653, h-index: 228)
American J. of Preventive Medicine     Hybrid Journal   (Followers: 21, SJR: 2.764, h-index: 154)
American J. of Surgery     Hybrid Journal   (Followers: 34, SJR: 1.286, h-index: 125)
American J. of the Medical Sciences     Hybrid Journal   (Followers: 12, SJR: 0.653, h-index: 70)
Ampersand : An Intl. J. of General and Applied Linguistics     Open Access   (Followers: 5)
Anaerobe     Hybrid Journal   (Followers: 4, SJR: 1.066, h-index: 51)
Anaesthesia & Intensive Care Medicine     Full-text available via subscription   (Followers: 55, SJR: 0.124, h-index: 9)
Anaesthesia Critical Care & Pain Medicine     Full-text available via subscription   (Followers: 9)
Anales de Cirugia Vascular     Full-text available via subscription  
Anales de Pediatría     Full-text available via subscription   (Followers: 2, SJR: 0.209, h-index: 27)
Anales de Pediatría (English Edition)     Full-text available via subscription  
Anales de Pediatría Continuada     Full-text available via subscription   (SJR: 0.104, h-index: 3)
Analytic Methods in Accident Research     Hybrid Journal   (Followers: 2, SJR: 2.577, h-index: 7)
Analytica Chimica Acta     Hybrid Journal   (Followers: 37, SJR: 1.548, h-index: 152)
Analytical Biochemistry     Hybrid Journal   (Followers: 166, SJR: 0.725, h-index: 154)
Analytical Chemistry Research     Open Access   (Followers: 8, SJR: 0.18, h-index: 2)
Analytical Spectroscopy Library     Full-text available via subscription   (Followers: 11)
Anesthésie & Réanimation     Full-text available via subscription   (Followers: 1)
Anesthesiology Clinics     Full-text available via subscription   (Followers: 22, SJR: 0.421, h-index: 40)
Angiología     Full-text available via subscription   (SJR: 0.124, h-index: 9)
Angiologia e Cirurgia Vascular     Open Access  
Animal Behaviour     Hybrid Journal   (Followers: 157, SJR: 1.907, h-index: 126)
Animal Feed Science and Technology     Hybrid Journal   (Followers: 5, SJR: 1.151, h-index: 83)
Animal Reproduction Science     Hybrid Journal   (Followers: 5, SJR: 0.711, h-index: 78)
Annales d'Endocrinologie     Full-text available via subscription   (Followers: 1, SJR: 0.394, h-index: 30)
Annales d'Urologie     Full-text available via subscription  
Annales de Cardiologie et d'Angéiologie     Full-text available via subscription   (SJR: 0.177, h-index: 13)
Annales de Chirurgie de la Main et du Membre Supérieur     Full-text available via subscription  
Annales de Chirurgie Plastique Esthétique     Full-text available via subscription   (Followers: 2, SJR: 0.354, h-index: 22)
Annales de Chirurgie Vasculaire     Full-text available via subscription   (Followers: 1)

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Journal Cover Advances in Molecular and Cell Biology
  [22 followers]  Follow
    
   Full-text available via subscription Subscription journal
   ISSN (Print) 1569-2558
   Published by Elsevier Homepage  [3044 journals]
  • Chloride‐Transporting Proteins in Mammalian Organisms: An Overview
    • Abstract: 2006
      Publication year: 2006
      Source:Advances in Molecular and Cell Biology, Volume 38



      PubDate: 2012-12-17T07:19:13Z
       
  • Physiological Functions of the CLC Chloride Transport Proteins
    • Abstract: 2006
      Publication year: 2006
      Source:Advances in Molecular and Cell Biology, Volume 38



      PubDate: 2012-12-17T07:19:13Z
       
  • Structure and Function of CLC Chloride Channels and Transporters
    • Abstract: 2006
      Publication year: 2006
      Source:Advances in Molecular and Cell Biology, Volume 38



      PubDate: 2012-12-17T07:19:13Z
       
  • Pharmacology of CLC Chloride Channels and Transporters
    • Abstract: 2006
      Publication year: 2006
      Source:Advances in Molecular and Cell Biology, Volume 38



      PubDate: 2012-12-17T07:19:13Z
       
  • The Physiology and Pharmacology of the CFTR Cl− Channel
    • Abstract: 2006
      Publication year: 2006
      Source:Advances in Molecular and Cell Biology, Volume 38



      PubDate: 2012-12-17T07:19:13Z
       
  • Gating of Cystic Fibrosis Transmembrane Conductance Regulator Chloride
           Channel
    • Abstract: 2006
      Publication year: 2006
      Source:Advances in Molecular and Cell Biology, Volume 38



      PubDate: 2012-12-17T07:19:13Z
       
  • Functional Properties of Ca2+‐Dependent Cl− Channels and Bestrophins:
           Do They Correlate'
    • Abstract: 2006
      Publication year: 2006
      Source:Advances in Molecular and Cell Biology, Volume 38



      PubDate: 2012-12-17T07:19:13Z
       
  • Cell Volume Homeostasis: The Role of Volume‐Sensitive Chloride
           Channels
    • Abstract: 2006
      Publication year: 2006
      Source:Advances in Molecular and Cell Biology, Volume 38



      PubDate: 2012-12-17T07:19:13Z
       
  • GABAergic Synaptic Transmission
    • Abstract: 2006
      Publication year: 2006
      Source:Advances in Molecular and Cell Biology, Volume 38



      PubDate: 2012-12-17T07:19:13Z
       
  • Physiology of Cation‐Chloride Cotransporters
    • Abstract: 2006
      Publication year: 2006
      Source:Advances in Molecular and Cell Biology, Volume 38



      PubDate: 2012-12-17T07:19:13Z
       
  • Plasma Membrane Cl−/HCO3− Exchange Proteins
    • Abstract: 2006
      Publication year: 2006
      Source:Advances in Molecular and Cell Biology, Volume 38



      PubDate: 2012-12-17T07:19:13Z
       
  • Orchestration of Vectorial Chloride Transport by Epithelia
    • Abstract: 2006
      Publication year: 2006
      Source:Advances in Molecular and Cell Biology, Volume 38



      PubDate: 2012-12-17T07:19:13Z
       
  • Contributors to Volume 38
    • Abstract: 2006
      Publication year: 2006
      Source:Advances in Molecular and Cell Biology, Volume 38



      PubDate: 2012-12-17T07:19:13Z
       
  • The Cytoskeleton of the Platelet
    • Abstract: 2006
      Publication year: 2006
      Source:Advances in Molecular and Cell Biology, Volume 37

      Platelets contain a membrane cytoskeleton, a cytoplasmic core cytoskeleton, and a microtubule system that are closely connected and act in concert to maintain the resting platelet discoid shape. A system of intracellular activatory and inhibitory signaling molecules interacts directly or indirectly with these cytoskeletal structures and tightly controls the cytoskeletal function. During platelet adhesion, activation, and aggregation, these cytoskeletal structures are rearranged resulting in the formation of a variety of F‐actin‐based structures, including filopodia and lamellipodia. Cytoskeletal remodeling is initiated by membrane receptors and signaling proteins that are in close contact with the platelet cytoskeleton. In turn, the cytoskeleton serves as a scaffold that binds and localizes signaling molecules at the right place and the right time to warrant platelet hemostatic function.

      PubDate: 2012-12-17T07:19:13Z
       
  • The Actin Cytoskeleton in the Apical Domain of Epithelial Cells
    • Abstract: 2006
      Publication year: 2006
      Source:Advances in Molecular and Cell Biology, Volume 37



      PubDate: 2012-12-17T07:19:13Z
       
  • The Connection Between Actin ATPase and Polymerization
    • Abstract: 2006
      Publication year: 2006
      Source:Advances in Molecular and Cell Biology, Volume 37

      Remodeling of the actin filament system in cells results from strictly regulated polymerization and depolymerization of actin, where hydrolysis of actin‐bound ATP is crucial. Actin–actin interactions are influenced by the state of the bound nucleotide, and many microfilament regulators influence the actin ATPase by binding preferentially either to ATP/ADP·Pi‐ or ADP‐bound actin. This chapter summarizes observations made concerning the actin ATPase and its role in the biological activity of actin and actin filaments.

      PubDate: 2012-12-17T07:19:13Z
       
  • Spectrin Function: A Survey of Genetic Systems from Drosophila to Humans
    • Abstract: 2006
      Publication year: 2006
      Source:Advances in Molecular and Cell Biology, Volume 37

      Spectrin and ankyrin are major components of a plasma membrane‐associated scaffold known as the spectrin cytoskeleton. Spectrin is thought to cross‐link actin filaments in a two‐dimensional submembrane network and ankyrin links the network to a number of integral membrane activities, including the sodium pump, voltage‐dependent sodium channels, and L1‐family cell adhesion molecules. Genetic studies have established that the spectrin cytoskeleton is required for the normal accumulation of these integral proteins at their normal sites of function. Defects in spectrin and ankyrin have been implicated in human disease, and studies in model genetic organisms are making it possible to elucidate the mechanisms behind their effects. Cell culture studies have also shed new light on the processes that govern formation of polarized membrane domains. This chapter surveys the results and their implications for the assembly and function of the spectrin cytoskeleton.

      PubDate: 2012-12-17T07:19:13Z
       
  • Structure and Function of Villin
    • Abstract: 2006
      Publication year: 2006
      Source:Advances in Molecular and Cell Biology, Volume 37

      Villin is an epithelial cell‐specific protein that belongs to a family of actin‐binding proteins that display structural and functional homology and include among other proteins, gelsolin, severin, fragmin, adseverin/scinderin, supervillin, and protovillin. Villin is unique among these proteins in that it can sever, cap, nucleate, and crosslink actin filaments. The actin modifying functions of villin are regulated by calcium, phosphoinositides, and tyrosine phosphorylation of the villin protein. Villin also self‐associates and this property of villin is likewise determined by its ligand‐binding properties. Overexpression of villin regulates actin redistribution, cell morphology, cell migration, and cell death. Studies done with the villin knockout mice substantiate the significance of villin in actin reorganization and maintenance of epithelial cell plasticity. In this chapter I discuss how the ligand‐binding properties of villin are mechanistically important to its functions in cell migration and cell death.

      PubDate: 2012-12-17T07:19:13Z
       
  • Roles of the Actin Cytoskeleton and Myosins in the Endomembrane System
    • Abstract: 2006
      Publication year: 2006
      Source:Advances in Molecular and Cell Biology, Volume 37

      The positioning of the endomembrane system (biosynthetic/secretory and endocytic pathways) and the constant movement of constituents between these compartments requires the involvement of the cytoskeleton and cytoskeletal‐based motors. Whereas much is known about the roles of the microtubule (MT) cytoskeleton in these events, considerably less is known about the roles of the actin cytoskeleton. Recent work has shown that the Golgi complex is linked to an actin‐based network that is important for Golgi morphology and the trafficking of Golgi‐derived membranes. Moreover, many of the cellular players used to transport cargo near the actin‐rich network subjacent to the plasma membrane (PM) may function near the Golgi.

      PubDate: 2012-12-17T07:19:13Z
       
  • The BRG1 and the Actin Filament System
    • Abstract: 2006
      Publication year: 2006
      Source:Advances in Molecular and Cell Biology, Volume 37

      The DNA in eukaryotic cells is organized with proteins into chromatin. The chromatin structure is dynamic, altered when factors that use DNA as a template need access or to silence regions of the chromosome. The alteration of the chromatin structure is primarily the responsibility of ATP‐dependent chromatin‐remodeling complexes and histone‐modifying complexes. ATP‐dependent chromatin‐remodeling factors of the SWI/SNF family affect the actin filament orgainzation in the cytoplasm. The SWI/SNF family of chromatin‐remodeling complexes is required in transcription of many genes, and the effect on the actin filament organization depends on cell type context, in particular, the various signaling pathways activated in each cell type. In many cell types, SWI/SNF complexes affect the protein level of adhesion molecules and Rho pathway effector molecules. Actin, together with actin‐related proteins (ARPs) are also present in the nucleus and are implicated in mRNA export, transcription, DNA repair, and chromatin remodeling. Actin associate to all three types of eukaryotic RNA polymerases (pol). In addition, actin and ARPs are part of several chromatin‐remodeling complexes purified from yeast, Drosophila, and mammalian cells. The function of actin and ARPs in the nucleus is still unclear, and it is proposed that they work as motor proteins or as structural proteins in different complexes.

      PubDate: 2012-12-17T07:19:13Z
       
  • Ionic Waves Propagation Along the Dendritic Cytoskeleton as a Signaling
           Mechanism
    • Abstract: 2006
      Publication year: 2006
      Source:Advances in Molecular and Cell Biology, Volume 37

      We outline the physical conditions that enable cytoskeletal polymers, such as actin filaments (AFs) and microtubules, to act as electrical transmission lines for ion flows along their lengths. For AFs we propose a model in which each protein subunit is an electric element with a capacitive, inductive, and resistive property due to the molecular structure of the filament and viscosity of the solution. Based on the conductivity rules that apply to electrical circuits, we discuss the properties of ionic waves that propagate along actin filaments. We then discuss the dynamics of C‐termini states in microtubules and their networks, including the interactions with ions and signal transmission via microtubule‐associated proteins. Experiments on ionic conductivity along AFs and microtubules validate the basic assumptions postulated in our models. As a consequence of these results we propose a new signaling mechanism in the cell, especially in neurons, that involves clouds of ions surrounding protein filaments which may travel without significant decay along the axon or the dendritic tree. These signals may be utilized to control various membrane properties, for example, the transition rate of ion channel opening and closing, local membrane conductivity, and vesicle trafficking.

      PubDate: 2012-12-17T07:19:13Z
       
  • The Functional Role of Actin Cytoskeleton Dynamics and Signaling
    • Abstract: 2006
      Publication year: 2006
      Source:Advances in Molecular and Cell Biology, Volume 37

      In this chapter we summarize experimental evidence supporting the hypothesis that rapid modifications of actin cytoskeleton dynamics may represent cellular sensory machinery, receiving extracellular signals and mediating early cell responses. A model “from structure to function” for actin cytoskeleton dynamics and signaling is presented. Nongenomic signaling pathways triggering rapid actin reorganization are analyzed and their regulatory role in various cell functions is discussed. The emerging data thus obtained on impaired actin cytoskeleton dynamics and signaling in malignant cells are addressed and potential strategies that can be applied for the manipulation of cancer cells based on these findings are provided. It is concluded that rapid modifications of actin cytoskeleton dynamics regulated by specific signaling pathways play a pivotal role in early nongenomic cell responses. Studying and understanding actin dynamics and signaling in malignant cells may represent a novel and challenging domain for cancer treatment in the future.

      PubDate: 2012-12-17T07:19:13Z
       
  • Regulation of the Actin Cytoskeleton by Phospholipids
    • Abstract: 2006
      Publication year: 2006
      Source:Advances in Molecular and Cell Biology, Volume 37

      The actin cytoskeleton plays a central role in various motile and morphogenetic cellular and developmental processes. The assembly and disassembly of actin filaments during these processes are precisely controlled by an array of actin‐binding proteins (ABPs). Studies have shown that phosphoinositides, especially PI(4,5)P2 and PI(3,4,5)P3, regulate the activities of many ABPs in vitro and have key roles in actin‐dependent cellular processes such as cytokinesis, phagocytosis, endocytosis, and cell migration. These phosphoinositides typically downregulate the activities of proteins promoting actin filament disassembly and upregulate proteins promoting actin filament assembly. Thus, PI(4,5)P2 and PI(3,4,5)P3 induce actin filament assembly both in vitro and in a number of distinct cellular processes.

      PubDate: 2012-12-17T07:19:13Z
       
  • Lipid Interactions of Cytoskeletal Proteins
    • Abstract: 2006
      Publication year: 2006
      Source:Advances in Molecular and Cell Biology, Volume 37

      At least 18 different cytoskeletal proteins have been shown to interact in vitro with, and in some cases are regulated by, specific membrane lipids, mostly phosphoinositides, whose synthesis is themselves regulated by extracellular signals. These lipid interactions are mediated by structurally diverse specific binding sites. Lipid interactions can serve to target proteins, such as spectrin, myosin X, dynamin, or annexin 2, to the plasma membrane or inactivate processes counteracting actin polymerization and stimulate proteins, such as Wiskott–Aldrich syndrome protein (WASP), involved in nucleating actin polymerization. In other cases (ezrin, talin), phosphoinositides serve to activate proteins involved in actin‐membrane linkage. Such interactions may occur highly localized in lipid rafts.

      PubDate: 2012-12-17T07:19:13Z
       
  • Embryo Morphogenesis and the Role of the Actin Cytoskeleton
    • Abstract: 2006
      Publication year: 2006
      Source:Advances in Molecular and Cell Biology, Volume 37

      During embryogenesis, the tissues of the developing embryo must be bent, tugged, and sculpted in a series of morphogenetic episodes that flow from one to another to generate the final shape of the fetus. The mechanisms underlying these events share startling similarities across a great variety of animals. A primary component of morphogenesis is the actin cytoskeleton, which drives all of the cell shape changes, the tissue bending, and the fusion events that characterize embryogenesis. In this chapter we explore how regulation of the actin cytoskeleton contributes to morphogenetic episodes in worm, fly, fish, mouse, and chick embryos. In particular, we focus on how each of the different structures formed by actin function in morphogenesis and consider how recent research has expanded our knowledge of this area.

      PubDate: 2012-12-17T07:19:13Z
       
  • Mechanisms of Ion Transport Regulation by Microfilaments
    • Abstract: 2006
      Publication year: 2006
      Source:Advances in Molecular and Cell Biology, Volume 37

      A major function of transporting epithelia is vectorial ion movement. This is accomplished by ion channels, pumps, antiporters, and symporters. The activity of these transport proteins is regulated by diverse signaling transduction and membrane trafficking events, many of which involve the actin cytoskeleton. This chapter will focus on the role of actin microfilaments and associated proteins in regulation of ion transport. The apical Na+H+ antiporter NHE3 will be examined in detail in this context due to its general biological importance as well as recent advances that have helped to elucidate the mechanisms of regulation of this protein. Appreciation of the mechanisms of NHE3 regulation should serve as a framework with which to understand cytoskeletal regulation of other transport proteins as well.

      PubDate: 2012-12-17T07:19:13Z
       
  • Domain‐Specific Phosphorylation as a Regulator of Intermediate
           Filaments
    • Abstract: 2006
      Publication year: 2006
      Source:Advances in Molecular and Cell Biology, Volume 37

      Intermediate filaments (IFs) are cytoskeletal structures that maintain cell and tissue integrity. In addition, they have been implicated in a number of other functions, including maintenance of cell shape, subcellular organelle positioning, support to cell migration, radial growth of axons, and scaffolding of signaling molecules. Many of the recognized tasks are affected by phosphorylation, which is the key mechanism to regulate both the organization of IFs and the association of IFs with interacting molecules. Another important function of IF phosphorylation is the disassembly of cytoplasmic and karyoskeletal IF networks during mitosis. An intriguing feature of IFs is the tripartite structure of their building blocks, with a highly conserved central rod domain, which is flanked by variable length N‐ and C‐terminal regions. While the rod domain is crucial for the assembly of IFs, a common feature of the distal domains is that they represent the main targets of phosphorylation. Since phosphate targeting seems to have domain‐specific functions, this chapter aims at summarizing the different roles of N‐ and C‐terminal phosphorylation of IFs.

      PubDate: 2012-12-17T07:19:13Z
       
  • Contributors to Volume 37
    • Abstract: 2006
      Publication year: 2006
      Source:Advances in Molecular and Cell Biology, Volume 37



      PubDate: 2012-12-17T07:19:13Z
       
  • Abbreviations and Acronyms
    • Abstract: 2006
      Publication year: 2006
      Source:Advances in Molecular and Cell Biology, Volume 37



      PubDate: 2012-12-17T07:19:13Z
       
  • Chapter 1 Lipid Rafts and Caveolae Organization
    • Abstract: 2005
      Publication year: 2005
      Source:Advances in Molecular and Cell Biology, Volume 36



      PubDate: 2012-12-17T07:19:13Z
       
  • Chapter 2 Caveolae and the Regulation of Cellular Cholesterol Homeostasis
    • Abstract: 2005
      Publication year: 2005
      Source:Advances in Molecular and Cell Biology, Volume 36



      PubDate: 2012-12-17T07:19:13Z
       
  • Chapter 3 The Caveolae Internalization Machinery
    • Abstract: 2005
      Publication year: 2005
      Source:Advances in Molecular and Cell Biology, Volume 36



      PubDate: 2012-12-17T07:19:13Z
       
  • Chapter 4 Lipid Raft-Mediated Entry of Bacteria into Host Cells
    • Abstract: 2005
      Publication year: 2005
      Source:Advances in Molecular and Cell Biology, Volume 36



      PubDate: 2012-12-17T07:19:13Z
       
  • Chapter 5 The Caveolin Interaction with Endothelial Nitric Oxide Synthase
           (eNOS)
    • Abstract: 2005
      Publication year: 2005
      Source:Advances in Molecular and Cell Biology, Volume 36



      PubDate: 2012-12-17T07:19:13Z
       
  • Chapter 6 Caveolae and Estrogen Receptor Signaling
    • Abstract: 2005
      Publication year: 2005
      Source:Advances in Molecular and Cell Biology, Volume 36



      PubDate: 2012-12-17T07:19:13Z
       
  • Chapter 7 eNOS Regulation by Sphingosine 1-Phosphate and Caveolin
    • Abstract: 2005
      Publication year: 2005
      Source:Advances in Molecular and Cell Biology, Volume 36



      PubDate: 2012-12-17T07:19:13Z
       
  • Chapter 8 Insulin Signaling and Caveolae
    • Abstract: 2005
      Publication year: 2005
      Source:Advances in Molecular and Cell Biology, Volume 36



      PubDate: 2012-12-17T07:19:13Z
       
  • Chapter 9 Caveolin-3, Caveolae, and Hereditary Muscle Diseases
    • Abstract: 2005
      Publication year: 2005
      Source:Advances in Molecular and Cell Biology, Volume 36



      PubDate: 2012-12-17T07:19:13Z
       
  • Chapter 10 Caveolae and Caveolins in the Vascular System: Functional Roles
           in Endothelia, Macrophages, and Smooth Muscle Cells
    • Abstract: 2005
      Publication year: 2005
      Source:Advances in Molecular and Cell Biology, Volume 36



      PubDate: 2012-12-17T07:19:13Z
       
  • Chapter 11 Caveolin Proteins in Cardiopulmonary Disease and Lung Cancers
    • Abstract: 2005
      Publication year: 2005
      Source:Advances in Molecular and Cell Biology, Volume 36



      PubDate: 2012-12-17T07:19:13Z
       
 
 
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