Publisher: Codon Publications   (Total: 3 journals)   [Sort by number of followers]

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Allergologia et Immunopathologia     Full-text available via subscription   (Followers: 2, SJR: 0.504, CiteScore: 1)
J. of Kidney Cancer and VHL     Open Access  
J. of Renal and Hepatic Disorders     Open Access  
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Journal of Renal and Hepatic Disorders
Number of Followers: 0  

  This is an Open Access Journal Open Access journal
ISSN (Online) 2207-3744
Published by Codon Publications Homepage  [3 journals]
  • Fibrolamellar Carcinoma with DNAJB1-PRKACA Fusion in a 16-Year-Old

    • Authors: Varsha Prakash, Neha Varshney
      Pages: 1 - 7
      Abstract: Fibrolamellar hepatocellular carcinoma (FLC) is a unique primary liver malignancy arising in noncirrhotic livers of young adults with an incidence of 0.02 per 100,000 in the USA (1). In the 5th edition of the WHO classification of the digestive system tumors published in 2019, fibrolamellar carcinoma is categorized as a subset of hepatocellular carcinoma (HCC). In 2014, the unique DNAJB1-PRKACA chimeric fusion protein was identified. Later studies proved this chimeric fusion protein as the main pathological driver in the disease manifestation of fibrolamellar carcinoma. Despite the invention of specific molecular genetic alteration in FLC, its oncogenic role and implication in FLC treatment remain an enigma. Surgical resection remains the primary therapeutic option, and the recurrence rate is extremely high (1). We present a case of fibrolamellar carcinoma in a pediatric patient with the PRKACA rearrangement resulting in DNAJB1-PRKACA fusion.
      PubDate: 2022-07-19
      DOI: 10.15586/jrenhep.v6i2.147
      Issue No: Vol. 6, No. 2 (2022)
       
 
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