JournalTOCs

International Journal of Research in Dermatology
Number of Followers: 1

This is an Open Access Journal

Open Access journal
ISSN (Online) 2455-4529
Published by Medip Academy

[12 journals]

Cytotoxic, cytostatic, and keratolytic activity of anti-dandruff shampoo
formulations
- Authors: Siddhivinayak S. Barve, Swapnil Deshpande, Pranjali P. Dhawal
  Pages: 61 - 66
  Abstract: Background: Dandruff is characterized by increased sebum production, yeast colonization, and hyper-keratinization leading to an itchy-flaky scalp. Ancillary non-microbial reasons for flaky scalp include ultraviolet rays and excessive heat from the sun. Thus, apart from traditional anti-fungal activity, anti-dandruff formulations should also possess the keratolytic activity and should be safe to use. Methods: Selsun, a shampoo formulation with 2.5% selenium sulfide (SS2.5), was tested in-vitro for its cytotoxic and cytostatic activities via cell viability of primary human dermal fibroblasts (HDFs). Its keratolytic activity was determined by assessing anti-proliferative activity on immortalized human keratinocyte (HaCaT) cell line. The shampoo was compared with 3 other shampoo formulations, one containing 2% ketoconazole (K2), second containing 2% ketoconazole with 1% zinc pyrithione (K2ZP1), and third containing 1% zinc pyrithione (ZP1). Results: Of the tested samples, SS2.5 and K2ZP1 showed cytostatic and keratolytic activity where the IC50 values on normal HDFs i.e., 0.521 mg/ml and 0.220 mg/ml, respectively, were higher than those on HaCaT cells (0.162 mg/ml and 0.198 mg/ml, respectively). SS2.5 displayed the highest keratolytic activity at IC50 of 0.162 mg/ml, followed by K2ZP1 (0.198 mg/ml) and K2 (0.267 mg/ml). On normal HDFs, SS2.5 showed the highest IC50 value (0.521 mg/ml), followed by K2 at 0.264 mg/mL, K2ZP1 at 0.220 mg/ml, and ZP1 at 0.139 mg/ml. Conclusions: SS2.5 was found to possess the highest cytostatic and keratolytic activities among all the shampoo formulations tested, thereby confirming its safety profile.
  PubDate: 2023-01-17
  DOI: 10.18203/issn.2455-4529.IntJResDermatol20230036
  Issue No: Vol. 9, No. 2 (2023)
Evaluation of effectiveness and tolerability of a moisturiser as an
adjuvant to isotretinoin therapy for acne: a real-world evidence
- Authors: Sushil T. Tahiliani, Vinay V. Saraf, Sonali P. Jadhav, Priya V. Poojary, Abhijit J. Vaidya, Sandesh V. Sawant, Madhumita S. Panda, Jaideep A. Gogtay
  Pages: 67 - 72
  Abstract: Background: Moisturizers are recommended as an adjuvant to acne therapies especially topical/systemic retinoids to counteract their cutaneous side-effects. Moisturisers also reduce inflammation and the intensity of acne. The compliment study was designed to evaluate effectiveness and tolerability of moisturiser (Excela, Cipla Ltd., Mumbai, India) in patients prescribed isotretinoin for managing their acne in real-world scenario. Methods: This open-label, observational, prospective, non-comparative multicentre study was conducted between June 2019 and January 2020. Patients who were prescribed Excela moisturiser as an adjuvant to isotretinoin for acne management were enrolled. After four weeks, the investigator graded the patient’s skin on smoothness and softness on a five-point scale and dryness, scaling and redness on a four-point scale. Its organoleptic characteristics and tolerability were evaluated using the subject assessment questionnaire. Results: We enrolled 200 patients (average age: 24.02±5.44 years). Investigators rated smoothness and softness of the skin as very good to excellent in 129 (64.5%) and 113 (56.5%) patients. No patient reported severe skin dryness, scaling or redness. Very good to excellent spreadability and appeal was rated by 132 (66.0%) and 133 (66.5%) patients, respectively. Eighty (40%) patients rated the moisturiser as non-greasy/non-sticky. Itching (1%), redness (0.5%), cold (0.5%), and cough (0.5%) were reported as adverse events but were of mild intensity and unrelated to the study product. No patient experienced serious adverse event or moisturiser-related adverse event. Conclusions: Overall, Excela moisturiser was effective and tolerable in patients with acne who were prescribed isotretinoin at the end of 4-week-long treatment period.
  PubDate: 2023-02-23
  DOI: 10.18203/issn.2455-4529.IntJResDermatol20230453
  Issue No: Vol. 9, No. 2 (2023)
Recurrent vesicular palmoplantar dermatitis: a clinical study in children
and adolescents
- Authors: Mrudula S., Thokchom Nandakishore, Linda Kongbam, Bhavya Valsalan, Nischith V., Lalthlamuana Ralte
  Pages: 73 - 77
  Abstract: Background: Previously known as dyshidrosis, recurrent vesicular palmoplantar dermatitis (RVPD) is presented as severe eruption of non -erythematous, symmetrical vesicles or bullae located along the lateral sides of fingers, on the palmar or plantar areas, and developing into a chronic and recurrent condition. Although very frequently observed on the hands, there are no specific studies about such eczema in children and adolescents. Objectives of current study was to study clinical profile of RVPD in children and adolescents, and monitor the association of RVPD with seasonal variations, hyperhidrosis, atopy and nickel sulphate. Methods: A cross sectional study was carried out in fifty patients affected by RVPD coming to out- patient department of dermatology in regional institute of medical sciences, Imphal, Manipur for a period of 24 months (October 2019 to September 2021) were collected using questionnaire. Data including age, sex, seasonal variation, hyperhidrosis, and atopy were collected. Relevant laboratory investigations like KOH examination, patch testing etc. were performed. Children (<12 years) and adolescents (13-18 years) irrespective of sex coming to opd were included and those unwilling to participate and treated elsewhere were excluded. Ethical approval was obtained from research ethics board and statistical analysis was done using IBM SPSS version 21. Results: Majority (44%) of patients were in the age group 1-5 years. Hyperhidrosis (12%) was identified as second most contributing factor for RVPD after idiopathic cases. Atopy was the most common associated factor followed by seasonal warm weather exacerbation. Conclusions: RVPD onset may occur at an early age, developing into a chronic and recurrent infection. Hyperhidrosis and atopic status was established in the clinical profile.
  PubDate: 2023-02-23
  DOI: 10.18203/issn.2455-4529.IntJResDermatol20230454
  Issue No: Vol. 9, No. 2 (2023)
Oral, conjunctival and Auricular Kaposi’s sarcoma in a HIV-negative
patient : an unusual presentation
- Authors: Ibtissame Boubnane, Salma Jebli, Kaoutar Znati, Karima Senouci
  Pages: 78 - 80
  Abstract: Kaposi’s sarcoma is an unusual multicentric malignant neoplastic disease, that characterized by the proliferation of spindle-shaped cells. This tumor is habitually involving in the skin of the lower extremities. However, it is rarely developing in the mucosa or skin of the head and neck. Herein, we report an uncommon presentation of Kaposi sarcoma affecting auricle,oral and ocula rmucosa in an immunocompetent patient. The diagnosis was made on clinical and histopathological finding.
  PubDate: 2023-02-23
  DOI: 10.18203/issn.2455-4529.IntJResDermatol20230455
  Issue No: Vol. 9, No. 2 (2023)
A case of successful yoga prana vidya energy healing treatment of contact
dermatitis caused by Holigarna ferruginea Marchand
- Authors: Venkata Satyanarayana Nanduri, Leelavathi Nayak
  Pages: 81 - 84
  Abstract: Contact dermatitis is a rash or a condition that makes skin red or inflamed with rashes and pain after direct contact with an allergen or an irritant such as soap, cosmetics, fragrances, jewellery and plants. This paper presents a case of Holigarna ferruginea Marchand induced allergic contact dermatitis successfully healed using yoga prana vidya (YPV) healing protocols. This paper uses a case study method collecting patient data before and after healing, and details of YPV intervention applied by trained certified healers for treating this patient. After one day healing, the patient's body temperature became normal. After 2 days of healing, rashes and itching reduced. After further 5 days of healing, the blister on the patient's right hand also completely healed. As an integrated holistic system, the YPV system of healing has been found to be a less expensive modality without the use of any medications and without touching the patient. The successful treatment of contact dermatitis using YPV techniques opens potential avenues for applying these techniques for numerous other skin ailments. Further research is recommended.
  PubDate: 2023-02-23
  DOI: 10.18203/issn.2455-4529.IntJResDermatol20230456
  Issue No: Vol. 9, No. 2 (2023)