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International Journal of Research in Dermatology
Number of Followers: 1  

  This is an Open Access Journal Open Access journal
ISSN (Online) 2455-4529
Published by Medip Academy Homepage  [12 journals]
  • A multicenter, retrospective study to evaluate the effectiveness, safety,
           and utilization patterns of super bioavailable itraconazole 50 mg in
           superficial dermatophytic infections

    • Authors: Vinod Khanna, Juzer Hussain, Shruti Patel, Dixit Patel, Alok Chaturvedi, Ankita Shah
      Pages: 522 - 528
      Abstract: Background: Objectives of the study were to assess the clinical characteristics of patients with superficial dermatophytic infections, and to evaluate the safety and effectiveness of super bioavailable (SB) itraconazole 50 mg.Methods: In this cross-sectional observational study, data of patients with superficial dermatophytic infections treated as per physician’s discretion was collected retrospectively from 71 centers across India between April 2021 and March 2022. Patient’s demographics, prescribing patterns of SB-itraconazole, and clinician-rated effectiveness and safety were evaluated.Results: Of 432 analyzed patients, 72.22% (n=312) had new infections, 27.77% (n=120) had recalcitrant/recurrent infections. Majority of the patients were males (66%) and aged 21-40 years (72.45%). Tinea corporis (27.08%) was the most common fungal infection followed by Tinea cruris (20.60%). SB-itraconazole was most commonly prescribed with water (63.88%; n=276); majority (55.8%) of the patients received SB-itraconazole post-meals. Majority of the patients achieved clinical (naïve: 71.47%; recalcitrant: 79.17%) cures within 4 weeks. The efficacy was excellent/good in 71.95% of patients who received SB-itraconazole as the first choice over conventional itraconazole for overall benefits as per the clinician’s global assessment; and in 87.22% of patients who received concomitant acid-lowering drugs. Most (83.33%) patients reported excellent/good compliance with SB-itraconazole. The clinicians’ rated this newer formulation of itraconazole (SB-itraconazole) as excellent/good in efficacy (83.33%) and safety (79.17%) for most patients.Conclusions: SB-itraconazole was effective and safe in patients with superficial dermatophytic infections. The effectiveness of SB-itraconazole was similar with high response rates for naïve and recalcitrant cases. Further, the efficacy was excellent/good in most patients receiving SB-itraconazole as the first choice over conventional itraconazole, or who received concomitant acid-lowering drugs.
      PubDate: 2022-10-27
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20222363
      Issue No: Vol. 8, No. 6 (2022)
  • The scenario of lepra reactions in a tertiary care hospital in Central

    • Authors: Hosalli Amrutha, Suga Reddy, Nadiga Rajashekhar, Anirudh M. Reddy
      Pages: 529 - 534
      Abstract: Background: Leprosy is a chronic disease with a benign course. Even though it is a curable disease, due to presence of bacilli in tissue hypersensitivity reaction may develop called lepra reactions. This study is conducted to see the number of patients with reactions, their onset, presentation, course and response to treatment.Methods: This is a retrospective study conducted over the period of 2 years from January 2017 to December 2019 in a tertiary care hospital of JJM Medical College at Davanagere. All confirmed cases after doing biopsy were included in the study. All the cases were classified according to Ridley-Jopling classification. Treatment was started based on World Health Organization (WHO) criteria for paucibacillary and multibacillary, for the duration of 6 months and 12 months accordingly.Results: Over the period of 2 years 178 cases of leprosy were registered. The majority of patients were seen in borderline tuberculoid leprosy spectrum (BT) that is in 29.2% of the patients, followed by in lepromatous leprosy (LL) seen in 26.4% of the patients. Lepra reactions were seen in 41 (23.03%) patients. Type 2 reaction (T2R) were more commonly observed that is in 27 patients (65.8%), type 1 reaction (T1R) is seen in 14 patients (34.1%). T2R were observed more commonly in LL spectrum.Conclusions: Reactions are more damaging than the disease itself. Hence, early diagnosis and proper management is important to prevent further reactions. This is can be done by good clinical knowledge about the disease and reactions and proper follow up of cases.
      PubDate: 2022-10-27
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20222723
      Issue No: Vol. 8, No. 6 (2022)
  • Study of endocrinal profile and trichoscopic features in female pattern
           hair loss at tertiary care hospital

    • Authors: Ravina R. Naik, Pankaj Shukla
      Pages: 535 - 542
      Abstract: Background: Patterned hair loss is one of the commonest conditions for which both men and women seek dermatologist. Though term androgenetic alopecia is used synonymously for female pattern hair loss, role of androgens and other hormones in its causation remains controversial. Also, in literature few studies are present suggesting role of trichoscopy in female pattern hair loss. We sought to investigate role of endocrine disturbances and trichoscopic findings in female pattern hair loss as per Ludwig classification.Methods: This was a prospective case control study. 100 cases and 100 age matched controls were enrolled in study. Laboratory investigations were done in both groups and trichoscopic examination was done in cases, at frontal and occipital scalp. The data was analyzed using t test, McNemar test and as mean, standard deviation and as percentages.Results: The difference between the mean value of body mass index, hemoglobin, T4, prolactin, follicle stimulating hormone, testosterone and dehydroepiandrosterone were found to be statistically significant as compared to controls. On trichoscopy, hair diameter diversity was commonest findings, however focal atrichia, 2-3 hairs/hair unit, white dots, honey comb pigmentation (HCP) correlated with grade of hair loss.Conclusions: Our study supports role of hormonal disturbances in causation of female pattern hair loss and thus we recommend doing tests in early onset and severe degrees of hair loss. Though diagnosis is mainly clinical trichoscopy could be excellent tool which is simple, non-invasive and cost-effective tool and may help to differentiate Female patterned hair loss from other condition like chronic telogen effluvium.
      PubDate: 2022-10-27
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20222724
      Issue No: Vol. 8, No. 6 (2022)
  • Open label, single arm, interventional multi-centered study to evaluate
           the efficacy and biophysical response of topical Soteri Skin cream in
           following skin conditions: atopic dermatitis, eczema, psoriasis and

    • Authors: Guneet Bedi, Pratisha Dash
      Pages: 543 - 550
      Abstract: Background: Eczema, also known as dermatitis, is characterized by skin inflammation, which presents as pruritus, skin dryness and erythema. Soteri cream, which was used in the study, contains Helianthus annus oil, glycerin, sodium hyaluronate, niacinamide and various ceramides. Niacinamide upregulates epidermal ceramide synthesis; thereby, strengthening epidermal barrier.Methods: The study was conducted on 30 patients in total, out of which, 5 patients were of scalp (3) and palmar psoriasis (2), 10 of eczema, 10 of atopic dermatitis and 5 of rosacea. The above patients were the ones coming to Aayna clinic for their respective skin concerns. After doing clinical examination and taking written consent, patients were given Soteri skin cream, to apply twice daily on the area of concern. Follow up was done fortnightly for a month. Patient’s assessment in follow up visits was done with clinical photographic, along with dermoscopic photographic assessment after a month and by filling proforma for effects and side effects using VAS and SCORAD score (for atopic dermatitis).Results: Complete symptomatic and visual improvement was seen in 3 patients of eczema, 2 of rosacea, 1 of scalp psoriasis and 6 of atopic dermatitis.Conclusions: Soteri skin cream with its unique formulation of ceramides and niacinamide resulted in significant improvement in psoriasis, hand and nummular eczema, atopic dermatitis and rosacea. It is a steroid free, valuable line of treatment for chronic eczema. 
      PubDate: 2022-10-27
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20222725
      Issue No: Vol. 8, No. 6 (2022)
  • Management of skin and soft-tissue infections and acne with topical
           nadifloxacin: a comprehensive review

    • Authors: Snehal Muchhala, Rashmi Sarkar, Koushik Lahiri, Rajendra D. Kharkar, Rahul Rathod
      Pages: 551 - 563
      Abstract: Skin and soft tissue infections (SSTIs) and acne are multi-factorial skin conditions that involve microbial invasion of the skin and underlying soft tissues; though, both have different pathogenesis. Most of these infections are caused by bacteria, affecting all age groups. Early diagnosis and appropriate antimicrobial therapy remain the cornerstone of management of SSTIs and acne. Over the years, an increase in antibiotic resistance has been reported with mupirocin and fusidic acid that makes the management of SSTIs and acne increasingly challenging. Further, these antibiotics are unable to penetrate biofilms and show their action on the microorganisms embedded deep in the polymeric matrix. In this review, we have discussed the current evidence on the efficacy and safety profile of nadifloxacin compared to other currently available antimicrobial agents. An extensive search was performed through PubMed and Medline using relevant key words. This article has highlighted nadifloxacin’s broad antimicrobial spectrum, unique dual mechanism of action, distinct characteristics like ability to retain efficacy in acidic pH, low antibiotic resistance and superior action against biofilms. This review concludes that nadifloxacin, could be a potential empirical therapy in the management of SSTIs and acne.
      PubDate: 2022-10-27
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20222726
      Issue No: Vol. 8, No. 6 (2022)
  • A rare case of elephantiasic pretibial myxedema with secondary cutis
           verticis gyrata

    • Authors: Phyo Zaw Aung, Pacharee Simsamer, Thamthiwat Nararatwanchai
      Pages: 564 - 567
      Abstract: A 61-year-old man with a history of thyrotoxicosis, diabetes mellitus, hypertension, and dyslipidemia presented to the dermatology outpatient clinic with bilateral non-pitting edema, asymmetrical yellowish-brown plaques, and nodules associated with some areas of hyperpigmentation, Peau’d orange appearance and elephantiasis-like skin lesions over both low legs. It was diagnosed as pretibial myxedema attributed to thyrotoxicosis. Additionally, convoluted folds and deep furrows similar to the cerebral cortical surface were seen on the forehead suggesting secondary cutis verticis gyrata (CVG) and our approach to the patient will be discussed in this case report. 
      PubDate: 2022-10-27
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20222727
      Issue No: Vol. 8, No. 6 (2022)
  • Dermoscopy of livedoid vasculopathy in skin of color treated successfully
           with colchicine: a case report

    • Authors: Balachandra S. Ankad, Sushila K. Nagur, Balkrishna P. Nikam
      Pages: 568 - 570
      Abstract: Livedoid vasculopathy (LV) is recurrent and episodic thrombotic dermatosis characterized by pain and ulcerations. It requires early diagnosis, and treatment with combination of drugs. Dermoscopy is a non-invasive technique which enables clinician to visualize subsurface structures of the skin. Here, dermoscopy of LV in skin of color which was treated with colchicine is reported. 
      PubDate: 2022-10-27
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20222728
      Issue No: Vol. 8, No. 6 (2022)
  • Management of formocresol burn-case report

    • Authors: Vrushali Raju Nandkule, Pratiksha Harishchandra More, Shailee Shelke, Rutuja Raju Nandkule, Yogita Uttam Landge
      Pages: 571 - 573
      Abstract: Formocresol is widely used in pediatric endodontics as a pulpotomy medicament. Formocresol helps to fix soft tissues in oral cavity such as pulp. Care should be taken while using formocresol proper isolation techniques should be used during its application as an endodontic material, because of its hazardous effects on soft tissue. This article elaborates the case of chemical burns due to improper handling of formocresol during dental treatment. It demonstrates the underlying effect such as moderate pain burning sensation and patchy dark discoloration of skin and its resolution.
      PubDate: 2022-10-27
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20222729
      Issue No: Vol. 8, No. 6 (2022)
  • A rare case of infliximab induced myeloperoxidase-cytoplasmic
           antineutrophil cytoplasmic autoantibody positive cutaneous vasculitis

    • Authors: Carly J. Robinson, Neil K. Jairath, Jon C. Davis, Hongyu H. Yang
      Pages: 574 - 577
      Abstract: Drug-induced cutaneous vasculitis is a known autoimmune complication of tumor necrosis factor (TNF) inhibitors with many instances resulting in the production of newly formed antibodies. We report a 21-year-old female with a past medical history of Crohn’s disease controlled with infliximab who presented to dermatology with a purpuric rash and crusted plaques of her distal lower extremities. Biopsy of a lesion revealed perivascular lymphocytes, neutrophils and eosinophils, vessel wall damage, and dermal eosinophils consistent with a drug-induced vasculitis. Follow up labs assessing for antibodies revealed unusual findings of an elevated cytoplasmic-antineutrophil cytoplasmic autoantibody (C-ANCA) titer and myeloperoxidase (MPO) antibody level making this patient MPO-C-ANCA positive. The patient’s lesions were treated with both oral and topical steroids, colchicine, and transition of her infliximab to ustekinumab with subsequent improvement of her lesions and normalization of antibody titers.
      PubDate: 2022-10-27
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20222730
      Issue No: Vol. 8, No. 6 (2022)
  • Kaposi`s varicelliform eruption in a case of pustular psoriasis

    • Authors: Naveen Netaji Rao, Sharanjit Singh Toor
      Pages: 578 - 580
      Abstract: Kaposi`s varicelliform eruption (KVE) is a disseminated cutaneous infection with herpesvirus type 1 or 2, vaccinia virus, or coxsackievirus A16 in a patient with another underlying dermatosis. When herpesvirus type 1 or 2 is the pathogenic virus, the term ‘‘eczema herpeticum’’ (EH) is used, independent of the underlying dermatologic diagnosis that preceded the eruption. Presenting a case of generalised pustular psoriasis who while on immunosuppressant therapy cyclosporine developed KVE on the 3rd week of therapy. Based on the nature of cutaneous eruption and the bed side Tzanck smear test he was diagnosed as Psoriasis herpeticum. He was treated with oral acyclovir for 15 days with complete resolution of the lesions. KVE rarely occurs in psoriasis. It is more often in those patients who are on immunosuppressant therapy like oral methotrexate, cyclosporine etc. A high index of suspicion is needed while managing skin eruptions in a known case of psoriasis.
      PubDate: 2022-10-27
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20222731
      Issue No: Vol. 8, No. 6 (2022)
  • Systemic lupus erythematosus presenting with bullous lesions, cutaneous
           vasculitis and laryngeal ulcerations-a rare association

    • Authors: Mrudula Pulletikurti, K. V. T. Gopal, P. V. Krishnam Raju, B. Rekha Rani
      Pages: 581 - 584
      Abstract: Bullous SLE is an uncommon complication of SLE with autoantibodies to type VII collagen of dermo-epidermal junction. We report a 31-year-old female who presented with vesiculobullous lesions in the photo exposed areas along with vasculitic lesions over palms and soles and ulcerations in the larynx. She also had history of photosensitivity and hair loss. Investigations showed significant anaemia and high titres of antibodies (ANA, anti-ds-DNA, anti Sm) confirming SLE. Histopathology showing sub epidermal blister with neutrophils and immunofluorescence favoured diagnosis of bullous SLE. The patient responded well to high dose parenteral steroids and dapsone. In view of high probability of renal involvement, patient was referred to nephrologist and is under regular follow up.  
      PubDate: 2022-10-27
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20222732
      Issue No: Vol. 8, No. 6 (2022)
  • Cutaneous sarcoidosis: a marker of underlying systemic disease

    • Authors: L. Satyanka, K. V. T. Gopal, P. V. Krishnam Raju, B. Rekha Rani
      Pages: 585 - 588
      Abstract: Sarcoidosis/Mortimer’s malady is a multisystem disease defined by presence of epithelioid cell granulomas without caseation in various organs.It involves mainly the lungs, eyes, skin, lymph node etc. We reported a 40 year old female who presented with multiple plaques over different regions of the body with past history of ulcerated lesion of scalp which healed with cicatricial alopecia. On thorough evaluation she was found to have involvement of multiple internal organs. Based on the clinical features and histopathological findings, a diagnosis of cutaneous sarcoidosis (plaque type) was made. Patient treated with systemic and topical corticosteroids resulting in marked improvement in her skin lesions were seen and pulmonary complaints also resolved.
      PubDate: 2022-10-27
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20222733
      Issue No: Vol. 8, No. 6 (2022)
  • Current understanding of multi-country human monkeypox outbreak: a
           narrative review

    • Authors: Geoffrey Vas
      Pages: 589 - 592
      Abstract: Outbreaks of infectious diseases have occurred throughout history. They appear to be increasing in frequency, particularly because of the increasing emergence of viral diseases from animals. Monkeypox is a zoonotic orthopoxviral, similar to smallpox, although with lower mortality. Cases of human monkeypox are rarely seen outside of west and central Africa. The current outbreak is the first of its kind where the transmission is reported in Europe without known links to Africa. India reported the first case of monkeypox from the Southeast Asia region in the state of Kerala, on July 14, 2022. India till now (August 2022) has reported nine monkeypox cases and one death owing to the viral zoonosis infection. It causes flu-like symptoms such as fever, chills, and rash, usually mild, and most patients recover without therapy. As with most viral illnesses, the treatment's mainstay of clinical management for a typical monkeypox infection is supportive symptom management. Acting quickly and proactively, focusing on building surveillance, promptly identifying monkeypox infection, and implementing preventive measures will be vital for containing this pandemic.
      PubDate: 2022-10-27
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20222734
      Issue No: Vol. 8, No. 6 (2022)
  • Multiparametric composite glow and radiance scale: an objective,
           scientific assessment tool for skin glow and radiance evaluation

    • Authors: Ritambhara ., Mukta Sachdev
      Pages: 593 - 600
      Abstract: There are numerous instruments available to assess pigmentation in terms of color, melanin, and other factors, but there is no standardized or validated tool to assess a person's glow and radiance. The MSCR- glow and radiance index (G&R)-composite scale was created with the help of a bio-physics background and includes five important factors. The scale is intended to provide an objective, scientific assessment tool for a highly subjective perception caused by numerous skin features. It should be emphasized that the scale is highly sensitive in measuring minor changes in the skin and generating numerical data that can be assessed using various statistical method. The numerical interpretation is also equivalent to measurements produced with a scientific instrument employing optometry principle, as evidenced by comparisons with other instruments. The assessment scale is an amalgamation of sensory visual evaluation with bio-physics that defines the optometric of the skin. The scale has been used to objectively assess skin glow and was found to be a highly sensitive assessment tool to assess all kind of dermatological products designed to provide enhanced glow and radiance.
      PubDate: 2022-10-27
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20222735
      Issue No: Vol. 8, No. 6 (2022)
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