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International Journal of Research in Dermatology
Number of Followers: 1  

  This is an Open Access Journal Open Access journal
ISSN (Online) 2455-4529
Published by Medip Academy Homepage  [12 journals]
  • Zymbilan┬«-PSO cream with nano-encapsulated RetileX-A┬«-PRO mitigates the
           clinical severity and relieves the symptoms of chronic plaque psoriasis:
           an interventional clinical study

    • Authors: Jan Wadstein
      Pages: 503 - 507
      Abstract: Background: Skin psoriasis is a serious inflammatory disorder with increased risk of rheumatic, cardiometabolic and psychosocial complications. At present, >50% of patients are dissatisfied with their treatment; thus, novel approaches are in high clinical demand. Retinoids are a major group of anti-psoriatic compounds; nonetheless, dose-dependent topical side effects have limited their effective topical application. RetileX-A®-PRO (Pharma Medico, Aarhus, Denmark) is a novel nano-encapsulated retinol ester designed to minimise the risk of skin irritation. The proprietary nano-encapsulation technology used in this compound can protect retinoid molecules from degradation, and thereby prolong and stabilise its release profile. The safety and efficacy of RetileX-A®-PRO were evaluated in this study.Methods: 45 patients (58% female, aged 18-80 years) with mild to moderate skin psoriasis were enrolled in a 4-week interventional study. Participants were treated once daily with Zymbilan®-PSO cream with RetileX-A®-PRO and evaluated both objectively and subjectively at baseline, after 8 hours and at endpoint.Results: Our observations demonstrated that Zymbilan®-PSO cream possesses both short-term and long-term anti-psoriatic effects. Shortly after application, objective skin characteristics were improved, and itching reduced in >84% of subjects. At endpoint, 87% of skin lesions improved, 9% did not change and 4% progressed as assessed by a dermatologist. Patients’ self-evaluation yielded similar results: 78% judged Zymbilan®-PSO cream as a ‘good’ to ‘very good’ skin care product with suitable cosmetic parameters. No side effects recorded in 95% of participants.Conclusions: In conclusion, Zymbilan®-PSO cream is a well-tolerated treatment that can mitigate both clinical severity and subjective symptoms of chronic skin psoriasis.
      PubDate: 2021-06-24
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20212544
      Issue No: Vol. 7, No. 4 (2021)
  • A study of clinical profile and quality of life in patients with scabies

    • Authors: Bindushree R., Abhineetha Hosthota
      Pages: 508 - 512
      Abstract: Background: Scabies is an ectoparasitic dermatosis caused by Sarcoptes scabiei and is a public health issue in all countries regardless of socioeconomic status. Scabies can lead to stigmatization, depression, insomnia, and may significantly affect the quality of life. The aim of the study was to find the demographic profile, clinical morphology and quality of life in patients suffering from scabies.Methods: This was a prospective, non-interventional, hospital-based cross-sectional study. Adult patients with scabies reporting to the dermatology department were enrolled in the study. Demographic details, clinical findings, past history and family history was recorded in a proforma. Questionnaire about quality of life was given to the patients and a detailed analysis was done.Results: A total of 120 cases of scabies were enrolled in this clinical study. The most affected age group was between 18 and 30 years. Most common site involved was interdigital spaces (83%) followed by genitalia (48%) and abdomen (42%). The most common lesion was excoriation (91%) followed by papule (88%) and nodules (33%). Out of 120 patients, 111(92%) patients experienced difficulty in working at the work place, 83.3% of patients had feeling of embarrassment, social relationship was affected in 82.5% of patients. Majority of the patients (38.5%) had mild impairment of quality of life.Conclusions: Feeling of embarrassment, difficulty in work place, social stigmata and depression were frequently observed in patients with scabies. In our study scabies mildly affected the quality of life.
      PubDate: 2021-06-24
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20212327
      Issue No: Vol. 7, No. 4 (2021)
  • Seasons and pediatric dermatoses: a cross-sectional observational study in
           an urban skin hospital

    • Authors: Laxmi B. Horatti, Kumar Dilip N. R., A. R. Shashikiran
      Pages: 513 - 516
      Abstract: Background: It is a well-known that climatic conditions and seasonal variation have a direct effect on skin and the prevalence of certain skin diseases change directly with changing seasons. The presence of certain skin diseases in children reflect the status of health, hygiene and personal cleanliness of the society. The aim of the study was to know the prevalence of various skin conditions in different seasons.Methods: All fresh cases of children under 12 years of age attending the skin OPD were recorded and were divided based on the three seasons i.e.; summer winter and rainy. The results were statistically evaluated.Results: The top six conditions of our study were impetigo, miliaria, pityriasis alba, scabies, xerosis and papular urticaria. Impetigo and miliaria were more common during summer season, xerosis during winter season and scabies during rainy season.Conclusions: Different climatic conditions have varied effect on the skin and may lead to various dermatoses. To effectively corelate between seasons and skin conditions more such extensive studies on different population and ethnic groups have to be conducted.
      PubDate: 2021-06-24
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20212545
      Issue No: Vol. 7, No. 4 (2021)
  • Cutaneous manifestations of chronic alcoholism in cases attending rural
           tertiary cases center: a descriptive cross-sectional study

    • Authors: P. Vidya Sagar, Vijayabhaskar Reddy, Navaneetha Reddy
      Pages: 517 - 521
      Abstract: Background: Alcoholism is a potentially fatal condition damages skin directly or through organ dysfunction. Studies suggested that dermatological manifestations have also been found to be a marker of alcohol misuse. The aim of the study was to assess the various cutaneous manifestations of alcohol dependence.Methods: This study consisted of 205 cases diagnosed with alcohol dependency attending dermatology department and psychiatry wards, above 18 years of age. A detailed clinical examination and dermatological examination including hair, nails, oral and genital mucosa was performed. Alcoholic liver disease was diagnosed on clinical findings, abdominal sonogram and LFT.Results: Among the study cases 50.25% cases had alcoholic liver disease. The severity of alcohol dependence score ranged from 1-60 with Ameena score of 24.68. It was seen that 45.23% (90) of alcoholics were mildly dependent, 41.7% (83) of alcoholics were moderately dependent, and 13.07% (26) were severely dependent on alcohol. Seborrheic dermatitis, urticaria, hyperhidrosis was among the commonly encountered dermatoses.Conclusions: Cutaneous manifestations are a significant pointer to underlying, perhaps undetected problem of alcohol dependency and an awareness of these signs is imperative to alter a dermatologist to problems of alcohol abuse even in a busy clinic.
      PubDate: 2021-06-24
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20212546
      Issue No: Vol. 7, No. 4 (2021)
  • Clinical profile of cutaneous adverse effects induced by topical
           corticosteroids and their source of information

    • Authors: Aliza Zaidi, Kshitij Saxena, Ven R. Koti, Anukriti Singh, Ayesha Khalid, Reyan A. Jamil
      Pages: 522 - 530
      Abstract: Background: Steroids are a wide range of chemical molecules that have varying physiological effects. Corticosteroids own anti-inflammatory and immunosuppressive effects. They also have anti-proliferative effects on keratinocytes. The present study was undertaken to study the clinical aspects of the use of topical corticosteroids leading to adverse effects and to know the source of information leading to its abuse.Methods: A cross-sectional observational study was carried out on cutaneous adverse effects of TC attending the dermatology outpatient department of Era’s Lucknow medical college and hospital between December 2018 and November 2020. The patients who applied TC for more than 1 month were taken into account. Patients who had cutaneous adverse effects suggestive of TC without details of agents were excluded.Results: Present study explored the patterns of use of topical corticosteroid, and its associated adverse effects in a total of 380 patients (aged 3 to 71 years; mean age 27.33±11.78 years; 52.9% males). Itching (72.4%), burning skin (64.5%) and skin color change (62.4%) were the three most common presenting complaints. Dermatophytoses (66.6%), acne (17.4%) and skin lightening (6.3%) were the three most common indications for use of topical corticosteroids.Conclusions: The present study showed that the practice of using non-dermatologist prescribed topical corticosteroid use is highly prevalent and is associated with a high burden of adverse effects. To prevent this there is a need to spread awareness regarding harms associated with abuse of non-dermatologist prescribed topical corticosteroid use.
      PubDate: 2021-06-24
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20212547
      Issue No: Vol. 7, No. 4 (2021)
  • Predictors of insulin resistance among women with acne vulgaris and
           polycystic ovarian syndrome presenting to a tertiary care hospital in
           North India

    • Authors: Mini Chandra, Koshinder Vats, Palak Garg, Abhishek Tibrewal
      Pages: 531 - 537
      Abstract: Background: Acne vulgaris is now being increasingly associated with hyperandrogenism or metabolic syndrome. The aim of the study was to know the burden and determinants of insulin resistance among females suffering from acne and polycystic ovarian syndrome (PCOS).Methods: This prospective observational study included non-pregnant females with acne and PCOS aged 14 to 36 years. PCOS was diagnosed using Rotterdam criteria. Insulin resistance (IR) was confirmed using HOMA-IR values. Important history was ascertained, and hormonal essays were done. SPSS version 22 was used for the analyses.Results: The average age of the 81 subjects was 22 (IQR: 19-23) years and median duration of acne was 8 (7-9) months. Their median (IQR) insulin level was 10.5 (8.4 - 18.5), fasting blood glucose was 82 (73.2 - 90) and HOMA-IR value was 2 (1.7 - 3.9). A total of 27 (33.3%) were diagnosed with IR. Subjects having IR had significantly lower FSH (median=3.1, IQR: 2.3-6.3), LH (3.0, 1.2-3.3) and insulin level (median=26.0, 18.5-28.5) versus those without IR (p=0.04, p=0.04 and p<0.001 respectively). Subjects with IR were more likely to be having irregular menses, weight gain, and acanthosis nigricans versus those without IR.  Conclusions: One-third of the patients with acne and PCOS also had IR according to the HOMA-IR values. All women with acne and PCOS should be considered for underlying IR and examined for other sign of impaired glucose tolerance.
      PubDate: 2021-06-24
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20212548
      Issue No: Vol. 7, No. 4 (2021)
  • Clinicopathological correlation in the diagnosis of granulomatous
           cutaneous disorders: a retrospective study

    • Authors: Manisha Nijhawan, Divya Yadav, Shivi Nijhawan, Damini Shaktawat
      Pages: 538 - 542
      Abstract: Background: To ascertain the various cutaneous granulomatous disorders and clinicopathological concordance in skin biopsies.Methods: The study included the patients with skin biopsy showing granulomatous infiltrate in a tertiary care center. The cases were categorized according to level of concordance into consistent, corroborative and inconsistent based on the concurrence between clinical and histological diagnosis.Results: Of the total 155 granulomatous disorder, 75.48% showed clinicopathological concordance, 19.35% showed corroborative diagnosis while 5.16% were inconsistent. The maximum number of biopsies performed were in the group of young adult (19-49 years, 57.41%). The most common type of granuloma found was of tuberculoid type and disorders were Hansen’s disease, fungal infection and cutaneous tuberculosis.Conclusions: Our study showed that the coordination of dermatologist and pathologist plays a pivotal role in making accurate diagnosis of granulomatous cutaneous dermatoses.
      PubDate: 2021-06-24
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20212549
      Issue No: Vol. 7, No. 4 (2021)
  • Syphilis on the rise-a retrospective study at a tertiary care hospital in
           Northeast India

    • Authors: Nandakishore Thokchom, Bharath Meka, Linda Kongbam, Mrudula S., Erika Salam, Tana Ananto, Deepa Yumnam, Bhavya Valsalan
      Pages: 543 - 546
      Abstract: Background: Syphilis is an important sexually transmitted disease known for quite a long time. Its recognition and efficient treatment have become all the more necessary in the era of HIV epidemic in many clinical situations.Methods: A retrospective observational study of 7 years (January 2013 to December 2019) in 43 patients of confirmed syphilis attending regional institute of medical sciences (RIMS), Imphal.Results: During 7-year study period a sharp rise in syphilis cases were present from 2018 till the end of the study. Out of 43 patients, 39 were males. The most common age group was 25-40 years. Half of them were married. Maximum were heterosexuals and only 8 were homosexuals. Premarital and extra marital exposures were seen in 18 and 3 patients respectively. Patients presented in different forms-primary (48.6%), latent (25.7%) and secondary syphilis (22.8%). No cases of congenital syphilis and neurosyphilis were seen. VDRL titres ranged from 1:4 to 1:32. Six patients had HIV co-infection. No atypical presentations were seen.Conclusions: Increasing cases of syphilis have been observed in recent years. Syphilis screening and prompt treatment amongst risk groups have become crucial along with proper surveillance and public health measures to prevent disease transmission.
      PubDate: 2021-06-24
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20212550
      Issue No: Vol. 7, No. 4 (2021)
  • Mask associated dermatosis: unmasking the challenges- a cross sectional

    • Authors: Ketki ., Sonali Gupta, Vijay Paliwal, Rachita Mathur, Deepak K. Mathur
      Pages: 547 - 551
      Abstract: Background: The novel coronavirus, referred to as SARS-COV 2 causing COVID 19, has become a great health challenge to the mankind. After its origin from Wuhan, China, it spread all over the globe within a short period of time. World Health Organization (WHO) officially declared COVID 19 as pandemic on 11th March, 2020. Aerosoles or droplets are the commonest mode of infection through respiratory tract making it mandatory to wear masks as a preventive measure.Methods: It is a cross-sectional study conducted over patients attending the out patients department of Dermatology. They were observed for presence of dermatosis over the face and categorized according to nature of dermatoses.Results: We observed 385 patients, 200 (52%) patients had new dermatoses and 185 (48%) patients noticed flare of existing dermatoses. The predominant new dermatoses were dermatophytosis, indentations, sweat induced dermatitis, urticaria, pressure urticaria developing with indentations, contact dermatitis to metal and other materials in 49 (24.5%%), 42 (21%), 42 (21%) ,38(19%), 19 (9.5%) and 10 (5%) cases respectively. The flared dermatoses were acne, rosacea , plane warts and molluscum contagiosum in 120 (64.8%), 24 (12.9%), 22 (11.9%) and 17 (9.2%) cases respectively. Koebnerisation of vitiligo and lichen planus was also seen in few subjects.Conclusions: The prolonged use of face mask may cause various infective and non infective facial dermatoses. In the current scenario, it is mandatory to wear face mask as a preventive measure hence it is important to wear the mask properly. However, care of the mask as well as breaks from the mask are important factors to avoid the development of mask associated dermatosis.
      PubDate: 2021-06-24
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20212551
      Issue No: Vol. 7, No. 4 (2021)
  • Chronic urticaria: a clinico-etiological study and autologous serum skin
           test role in chronic idiopathic urticaria

    • Authors: Purnachandra Badabagni, Sruthi Thammineedi, Ramadevi Birudala
      Pages: 552 - 557
      Abstract: Background: Appearance of wheals daily for more than six weeks is chronic urticarial (CU). No cause is identified in about 50-70% of chronic urticaria patients and are labelled as chronic idiopathic urticaria (CIU). The aim of the present study is to study the clinical and etiological pattern of chronic urticaria and to find out the incidence of autoimmune urticaria by performing autologous serum skin test (ASST) in patients with CIU.Methods: This was a cross sectional study enrolling 100 chronic urticaria patients satisfying including and excluding criteria. The study was done for a period of 1 year. ASST was done in all the CIU patients after recording detailed history, complete physical and systemic examination.Results: Most of the patients (33%) were in 21-30 years age group with female preponderance (66%). Students (38%) followed by house wives (27%) were majorly involved. 21% patients had history of atopy and 8% had abnormal thyroid function tests. Causative factors noticed in 46% patients and remaining were idiopathic (54%). Infections (32.6%) constituted the major etiological factor followed by physical urticaria (30.4%), food (23.9%), medication (11%) and inhalants (2.1%). In infective agents, 46.6% were bacterial followed by helminthic (33.3%). In 29.6% of CIU patients, the ASST was positive indicating auto-immune urticaria.Conclusions: The etiology cannot be identified in most number of patients and hence they were labelled as CIU and the common causative agents observed were infections followed by physical urticaria, food and medication. ASST is considered as the relevant screening test to detect autoimmune urticaria.
      PubDate: 2021-06-24
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20212552
      Issue No: Vol. 7, No. 4 (2021)
  • The study of epidemiological, clinical, histopathological and dermoscopic
           features of lichen planus

    • Authors: Laxmi B. Horatti, Abhiram Rayapati, Dilip Kumar N. R., Shashikiran A. R.
      Pages: 558 - 564
      Abstract: Background: Lichen planus (LP) is a common papulosquamous condition seen by the dermatologists. It can involve the skin, mucous mebranes, hair and nails. There are many subtypes of LP with various clinical, histopathological and dermoscopic features. In this study we intended to study the epidemiological, clinical, histopathological and dermoscopic features of LP.Methods: A total of 73 patients of LP, above the age of 18 years who qualified the inclusion and exclusion criteria were included in the study. A proforma of epidemiological details was noted, clinical and dermoscopic examination of the lesions were done. The punch biopsy specimens of cutaneous lesions were subjected to histopathological examination and the findings noted.Results: Out of the 73 patients included in the study, 44 were males and 29 females with a ratio of 1.51:1. Classic LP was the commonest type of LP. Wickham’s striae (WS) was the most typical and commonest dermoscopic feature of cutaneous LP except lichen planus pigmentosus. Hyperkeratosis, hypergranulosis, acanthosis, band shaped lymphocytic infiltrate, melanophages, basal cell degeneration and saw tooth shaped rete ridges were the significant histopathological features.Conclusions: LP is more common in young adults and shows a male preponderance. WS is the most important diagnostic feature seen on dermoscopy of all the cutaneous types of LP excluding LPP. Interface dermatitis with a band of lymphocytic infiltrates and dermal melanophages is a notable feature of histopathology of LP.
      PubDate: 2021-06-24
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20212553
      Issue No: Vol. 7, No. 4 (2021)
  • Dermatologic manifestation of COVID-19: a systematic review

    • Authors: Annisa Alviariza, Luh M. Budiani
      Pages: 565 - 571
      Abstract: Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infections, causing disease known as COVID-19, has been associated with a myriad of symptoms, including dermatological ones. Despite there has been a consensus on pulmonary and systemic signs and symptoms of COVID-19, the same cannot be said of dermatological ones. We write in attempt to find a common theme of dermatological manifestations of COVID-19. We conducted literature searches from Medline databases as well as Google Scholar using keywords “cutaneous manifestations of COVID-19” and “dermatologic manifestations of COVID-19”. We included case series in our pooled descriptive analysis to describe types of cutaneous eruptions, localizations, and associated symptoms among COVID-19 patients with confirmed real time-polymerase chain reaction (RT-PCR) results. We included 12 case series in our pooled analyses with 2 more analyzed separately due to non-comparable data presentations. The results identified common types of cutaneous eruptions associated with COVID-19 to be maculopapular rash, urticaria, vesicular rash, vascular rash. Eruptions tend to be localized on the trunks, with lesser frequency found on extremities, and eruptions are often accompanied by pruritus of varying intensity. These various eruptions are associated with two distinct pathological pathways, namely inflammation of skin tissues, causing inflammatory rashes, and hypercoagulable state which is associated with vascular rashes. Our literature review identified several common types of cutaneous eruptions associated with COVID-19 with different proposed pathophysiological mechanisms for inflammatory and vascular rashes. This review is limited by its data sources which includes only case series as well as the fact that at this stage in the pandemic, little biomolecular research has been conducted to definitively associate SARS-CoV-2 infection with cutaneous manifestations.
      PubDate: 2021-06-24
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20212554
      Issue No: Vol. 7, No. 4 (2021)
  • Rapid development of multiple nonmelanoma skin cancers secondary to
           ruxolitinib: a case report

    • Authors: Trevor A. Nessel, Jeffrey B. Morris, Tyler Roshak, Bryan D. Sofen
      Pages: 572 - 574
      Abstract: Janus kinase (JAK) inhibitors are immunosuppressive medications that function by deactivating the JAK-STAT pathway causing inhibition of cellular growth. Ruxolitinib is a JAK inhibitor that is commonly used to treat disease processes such as myelofibrosis, polycythemia vera and graft versus host disease, with some evidence of benefit with prostate cancer as well. Side effects of ruxolitinib include increased risk of infection, pancytopenia, cardiovascular disease and malignancy relating to the medication’s immunosuppressive effects. Here we reported a 69-year-old male with prostate cancer being treated with ruxolitinib who developed multiple nonmelanoma skin cancers over a 13-month period.
      PubDate: 2021-06-24
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20212555
      Issue No: Vol. 7, No. 4 (2021)
  • Recurrent pyogenic granuloma within a port wine stain

    • Authors: Muhammed Haneefa, Mohammed Alshahrani, Sayed Agha A. Shah, Abdulmajeed Alshahrani
      Pages: 575 - 577
      Abstract: Pyogenic granuloma (PG) is a common vascular growth usually seen on the face and extremities following trauma, drugs like retinoids, antineoplastic agents or pregnancy. PG and port-wine stain (PWS) represent different types of vascular lesions that may rarely occur in association. PG arising in a PWS is usually reported following trauma, pregnancy or laser treatment of PWS. Any growth in a long-standing vascular lesion creates panic in the patient and a challenge to the physician, especially in the head and neck area. We report a case of recurrent PG emerging de novo in three different locations within the same PWS in a 24 year old male. A review of literature about the coexistence of both conditions is presented here, together with dermoscopic features.
      PubDate: 2021-06-24
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20212556
      Issue No: Vol. 7, No. 4 (2021)
  • Multifocal cutaneous epithelioid hemangiodothelioma on the same lower limb

    • Authors: Mehdi Khallaayoune, Elgaitibi Fatima Azzahra, Meziane Mariame, Senouci Karima
      Pages: 578 - 580
      Abstract: Epithelioid hemangioendothelioma (EHE) is a rare low-grade vascular tumour mainly affecting bones, deep soft tissues and exceptionally the skin. Multifocal cutaneous involvement is uncommon and should raise suspicion for metastasizing extracutaneous epithelioid hemangiodothelioma. Hereby we report the case of a young patient with multifocal cutaneous EHE involving the same lower limb. We emphasize the necessity for dermatologists to evoke the diagnosis of EHE in patients presenting with nonspecific tumours of the extremities. Prompt management and diagnosis are essential in this potential aggressive tumour.
      PubDate: 2021-06-24
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20212557
      Issue No: Vol. 7, No. 4 (2021)
  • Erythrokeratoderma variabilis: a case report

    • Authors: Yogesh Devaraj, Ranga Swaroop Mukunda, Rashmi R. Mallya, Taranpreet Kaur Kalra, Shaila Shree Devendra
      Pages: 581 - 583
      Abstract: Erythrokeratodermia variabilis (EKV) was first described by Mendes da Costa. It is a rare heterogeneous group of inherited cornification disorders characterized by two distinct types of skin lesions: fixed hyperkeratotic plaques and sharply marginated, pruritic, migratory erythematous lesions. We report a case of EKV in a 44-year-old male patient.
      PubDate: 2021-06-24
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20212558
      Issue No: Vol. 7, No. 4 (2021)
  • Hair: more than just an appendage

    • Authors: Harshitha Reddy, Srikanth Shanmugam, Manobalan Karunanandhan
      Pages: 584 - 586
      Abstract: Hypotrichosis is a relatively common feature of a number of complex hereditary syndromes. However, the isolated variant, called hereditary hypotrichosis simplex (HHS), is uncommon. We present a 4 years old child and his father who presented to us with features suggestive of HHS. No other associated ectodermal and systemic abnormalities were noted.
      PubDate: 2021-06-24
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20212559
      Issue No: Vol. 7, No. 4 (2021)
  • Clinicopathological and dermoscopic correlation of pigmented basal cell

    • Authors: Duttala Indira Reddy, Sivaramakrishnan Sangaiah, Vignesh N. R., Sukanya G.
      Pages: 587 - 589
      Abstract: Basal cell carcinoma (BCC), also known as basal cell epithelioma is the most common cutaneous malignancy affecting fair skinned individuals arising from sun exposed skin especially head and neck area. It is a slow growing tumor which rarely metastasizes. UV radiation is the most important predisposing factor. It includes mainly four variants: (a) nodular, (b) pigmented, (c) superficial BCC, (d) sclerosing or morphea form of which most common is nodular variant. Dermoscopy of pigmented BCC shows well focussed arborizing vessels which is the hallmark. The best modality of treatment is surgical excison of tumour, electrodesiccation and curettage, cryosurgery, and Mohs micrographic surgery.
      PubDate: 2021-06-24
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20212560
      Issue No: Vol. 7, No. 4 (2021)
  • Paint brush hair: a case report

    • Authors: Rajesh Munusamy, Aishwarya Lakshmi Sekar
      Pages: 590 - 592
      Abstract: Trichorrhexis nodosa (TN) is an hair shaft disorder presenting with whitish nodes all over the hair (diffuse form) or localized to an area (localized form) and could be either congenital or acquired. TNis ultimately a response to physical or chemical trauma that leads to formation of nodes along the hair shaft. Here, we reported a case of TNof the beard, diagnosed clinically and through trichoscopy. Patient was advised to shave his beard hair and to avoid brushing completely. On follow-up, the patient was symptomatically better. Based on this, TNof the beard was confirmed.
      PubDate: 2021-06-24
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20212561
      Issue No: Vol. 7, No. 4 (2021)
  • Extensive erythema elevatum diutinum associated with IgA monoclonal
           gammopathy: a rare case report

    • Authors: Manish Rijhwani, Divya Yadav, Manisha Nijhawan, Arvind Verma
      Pages: 593 - 595
      Abstract: Erythema elevatum diutinum (EED) is a rare form of leukocytoclastic vasculitis with an unclear pathogenesis. Almost 250 cases of EED have been reported in the literature, associated with several diseases and presented with various clinical features. Term 'diutinum' means chronic, describes one of the main characteristic features. The duration is very long, varying between one to more than 39 years. We report a rare presentation of EED in a 58-years-old man who presented with extensive and symmetrical, persistent, erythematous to violaceous   plaques over trunk and limbs and popular-nodular lesions present over pinna and dorsum of hands with burning sensation and itching over few lesions, in association with IgA monoclonal gammopathy.
      PubDate: 2021-06-24
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20212562
      Issue No: Vol. 7, No. 4 (2021)
  • Cutaneous hyperalgesia in the setting of COVID-19 infection: reporting 2
           cases from North India

    • Authors: Ipshita Bhattacharya, Ananta Kanwar, Keshav Sachdeva, Vishnu Choudhary
      Pages: 596 - 599
      Abstract: COVID-19 (Coronavirus disease) infection can manifest with a variety of dermatological and neurological symptoms which might have similar underlying patho-mechanisms. Here we report 2 cases of rt-PCR (Real time PCR) positive COVID infection who developed cutaneous hyperalgesia during the illness and review the case reports, case series, and other literature available on this symptom. We found that out of the total 13 reported cases (including the two cases reported here), most common onset of this symptom was within the first 3 days of illness (median duration ten days). Common sites of involvement included abdomen and back, but chest, arms and legs could also be involved. Warm baths, gabapentin and pregabalin showed good efficacy in relieving the symptom. The exact pathogenesis remains unclear but is hypothesised to be due to the neurotrophic properties of the virus and/or the inflammatory cytokines released during the illness. Further studies are necessary to expand the scope of knowledge in this regard.
      PubDate: 2021-06-24
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20212563
      Issue No: Vol. 7, No. 4 (2021)
  • Juvenile type II Waardenburg syndrome: a rare case report in Kerala

    • Authors: Abhijith V., John Thomas, Jisha James, Niveditha Dileep
      Pages: 600 - 604
      Abstract: Rare diseases are many in number but their treatments are less, as most of these rare diseases are genetical and there is no complete cure for a genetic disorder. Waardenburg syndrome (WS) is one among that type of rare genetic disorder thus the treatment is limited but the number of cases are increasing. This was the case report of a newborn baby showing major symptoms of WS. The patient got it through paternally. To make a final conclusion, various diagnostic tests were conducted including the family history as the patient's father had premature grey hairs and white patches on the body. Even though there is no complete cure for this disease condition, the sign and symptoms can be controlled before making it into a major disability. This case report typically dealt with the major types, clinical presentation, diagnosis and supportive therapy for a patient diagnosed with WS. Also showed the crucial role of consanguineous parents on this syndrome because the children affecting this rare syndrome are increasing. This report showed that further studies are required to check how the colour of the hair is changing in WS patients and what is happening to the gene involved in the production of melanin. Also, studies are required the find why WS typically affecting the major sensory organs such as eyes, ears, nose and skin.
      PubDate: 2021-06-24
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20212564
      Issue No: Vol. 7, No. 4 (2021)
  • Eosinophil rich infiltrate in secondary syphilis a rare histopathological

    • Authors: Vidya D. Kharkar, Harish B. Rajendran
      Pages: 605 - 608
      Abstract: Secondary syphilis is a sexually transmitted infection, which is referred to as “the great imitator” and has a wide spectrum of clinical manifestations. Syphilis is classically associated with plasma cells and the presence of eosinophils usually argues against a diagnosis of syphilis. The differential diagnosis for eosinophil-rich skin lesions often includes a drug reaction, arthropod-bite reaction, allergic contact dermatitis, and a response to a helminth infestation. However, many unrelated entities, such as infections, neoplasms, and inflammatory dermatoses can have prominent eosinophilic infiltrate. We report a case of secondary syphilis which on histopathology showing psoriasiform hyperplasia with superficial perivascular infiltrate and on higher magnification these infiltrate were predominantly lymphohistiocytic along with the moderate amount of eosinophils with a paucity of plasma cells. This case report is presented to highlight the need for including secondary syphilis as one of the differential diagnoses in the presence of eosinophil-rich infiltrate when it is suspected clinically.
      PubDate: 2021-06-24
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20212565
      Issue No: Vol. 7, No. 4 (2021)
  • An immunologic intrigue: psoriasis vulgaris developing on pemphigus

    • Authors: Deepali C. Tarate, Rachita Misri, Vinod K. Khuranna
      Pages: 609 - 612
      Abstract: Pemphigus foliaceous is an autoimmune blistering disease characterized by superficial flaccid blisters, erosions, scales and crusts on the seborrheic areas of the face and trunk. Mucosal involvement is seldom seen. The first report by Bloom in 1929, stated the coexistence of pemphigus foliaceous and psoriasis vulgaris. Since then, very few cases of psoriasis coexistent with autoimmune bullous diseases have been reported in which psoriasis had preceded or simultaneously presented with pemphigus foliaceous. We reported a rare case where psoriasis vulgaris developed in case of pemphigus foliaceous after 20 years.
      PubDate: 2021-06-24
      DOI: 10.18203/issn.2455-4529.IntJResDermatol20212566
      Issue No: Vol. 7, No. 4 (2021)
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Heriot-Watt University
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