Publisher: Medip Academy   (Total: 12 journals)   [Sort by number of followers]

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Intl. J. of Advances in Medicine     Open Access   (Followers: 5)
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Intl. J. of Clinical Trials     Open Access   (Followers: 5)
Intl. J. of Community Medicine and Public Health     Open Access   (Followers: 8)
Intl. J. of Contemporary Pediatrics     Open Access   (Followers: 11)
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International Journal of Contemporary Pediatrics
Number of Followers: 11  

  This is an Open Access Journal Open Access journal
ISSN (Print) 2349-3283 - ISSN (Online) 2349-3291
Published by Medip Academy Homepage  [12 journals]
  • Secondary attack rate among high-risk contacts of COVID-19 paediatric
           index cases: a study at the beginning of the pandemic in Pune city of
           Western Maharashtra, India

    • Authors: Ganesh R. Jagadale, Muralidhar P. Tambe, Yallapa Jadhav, Pradip S. Borle, Malangori A. Parande, Minal Hatnapure, Priyanka Salunke, Pradnya Shinde, Apeksha Paunikar, Arundhati Galande
      Pages: 1920 - 1925
      Abstract: Background: The COVID-19 was the emerging disease caused by SARS-COV2. Efficient transmission of this disease occurs through droplets and fomites. The susceptibility of children to coronavirus disease-19 (COVID-19) and transmission of COVID-19 from children to others is a relatively unexplored area. The aim of this study was to understand the transmission dynamics of severe acute respiratory syndrome coronavirus 2 in children. Study objectives were to estimate secondary attack rate of COVID-19 from paediatric index case during the early phase of pandemic in Pune city and to identify factors associated with transmission and development of the COVID-19 disease.Methods: This was a retrospective cohort study conducted in the month of June 2020. The sample includes 58 contacts of 11 laboratory confirmed pediatric index cases of COVID-19 from Pune municipal corporation after written informed consent. A confidential telephonic interview of parents was taken by using a prestructured questionnaire which includes socio-demographic data, family background, type of house, development of symptoms, outcome etc.Results: The mean age of primary pediatric case was 12.7±5.1 years. All of them were symptomatic. The SAR estimated was 55.2%. The factors significantly affecting SAR were comorbidity, no. of family members, type of family, overcrowding, no. of rooms, bedroom attached with toilet.Conclusions: The household SAR from paediatric patients is high and is closely associated with family size and other household characteristics. Hence, home quarantine should be advocated in smaller families with appropriate isolation facilities; more emphasis is given to co-morbid individuals.
      PubDate: 2021-11-23
      DOI: 10.18203/2349-3291.ijcp20214529
      Issue No: Vol. 8, No. 12 (2021)
       
  • Foot length as a surrogate maker to identify birth weight

    • Authors: Nitesh Upadhyay, Minhajuddin Ahmed
      Pages: 1926 - 1931
      Abstract: Background: Gestational age and birth weight is an important predicator for morbidity and mortality in neonates. Aim was to determine the correlation of foot length with birth weight and gestational age in neonates.Methods: This was a prospective observational study done in the neonatal unit department of pediatrics in Chirayu medical college and hospital, Bhopal. There were 1739 deliveries included during the study period from January 2016 to December 2020. Study group comprised of all live born babies delivered in within 24 hours of birth who fulfilled the inclusion criteria.Results: The study comprised of 1739 newborn babies, out of which 896 (51.51%) were males and 843 (48.49%) were females. Male:female ratio 1.06:1. In our study group, 337 (15.6%) babies were preterm and 1385 (84.39%) were of term gestation. We found a positive linear correlation of foot length with all birth weight groups in a newborn with a correlation coefficient (r=0.78) and p<0.001 was found. Similarly, a positive correlation of foot length and gestational age of newborn in both term and preterm babies with (r=0.83) with p<0.01. Foot length has 87.4% sensitivity and 91.7% specificity among low-birth-weight babies with respect to cut off foot length of 75.5 mm. Foot length has 78.7% sensitivity and 63.7% specificity among preterm babies.Conclusions: Foot length can be used as a screening tool to identify low birth weight (LBW) and preterm babies as it had a higher sensitivity and specificity.
      PubDate: 2021-11-23
      DOI: 10.18203/2349-3291.ijcp20214530
      Issue No: Vol. 8, No. 12 (2021)
       
  • Depression and coping strategies used among adolescents with cystic
           fibrosis

    • Authors: Surya Kant Tiwari, Rimple Sharma, Poonam Joshi, Sushil Kumar Kabra
      Pages: 1932 - 1938
      Abstract: Background: Cystic fibrosis (CF), an autosomal recessive monogenic chronic disorder affects the lungs, pancreas, and other exocrine glands, and manifests as recurrent respiratory infections, malabsorption, and a myriad of complications pertaining to other systems like hepatobiliary, endocrine and reproductive systems.  Objectives were to assess the level of depression among adolescents with CF, to assess the coping strategies used by adolescents with CF and to find an association between selected sociodemographic and clinical variables with depression.Methods: In a cross-sectional survey, 30 adolescents with CF in the age group of 12-18 years, attending the specialty clinic of a selected tertiary care facility were enrolled using a purposive sampling technique. Tools consisting of sociodemographic and clinical profile, patient health questionnaire (PHQ)-9, and ways of coping with CF were used for data collection.Results: Most of the adolescents with CF (66.7%) had depression of varying severity with 36.7% having moderate-severe to severe depression. The frequently used coping strategies by the adolescents with CF were hopefulness (76.66±11.29), followed by optimistic acceptance (70.23±13.04).  The individual coping strategy with the highest mean score was “having confidence on doctor and treatment” (3.83±0.37), while ‘I cry, eat, drink or take drugs’ had the lowest score (1.6±1.00).Conclusion: Depression is a common problem among adolescents with CF requiring regular screening and referral to experts for enhancing their coping strategy of optimistic acceptance. 
      PubDate: 2021-11-23
      DOI: 10.18203/2349-3291.ijcp20214531
      Issue No: Vol. 8, No. 12 (2021)
       
  • Impact of postnatal counseling on care of newborn

    • Authors: Vantaku Venkata Vijayalakshmi, K. Jhansi Padma, M. Madan Mohan, D. Manikyamba, A. Krishna Prasad
      Pages: 1939 - 1946
      Abstract: Background: Newborn care is an integral aspect of child health care practices. Globally 2.4 million children died in the neonatal period in 2019. Currently in India around 7.47 lakh neonates die annually. Advocating and adopting proper postnatal care of newborn in aspects of breastfeeding, immunization, warmth care, cord care, eye care etc will help in reducing neonatal morbidity and mortality.Methods: This was an hospital based cross sectional study of 100 postnatal mothers of babies admitted in NICU, in a tertiary care hospital. The knowledge of the mothers on various aspects of postnatal care was assessed by a pretest, followed by counseling and reassessment with a post test.Results: The study found that postnatal mothers had better awareness regarding breastfeeding, warmth care, cord care and oil massage. Poor knowledge was seen regarding eye care, immunization, recognition of danger signs and maternal nutrition and supplementation. Health care workers focused more on breastfeeding and warmth care practices than other aspects of postnatal care during antenatal counseling which could be a reason for this. A wide gap exists between contact with health workers and antenatal counseling. Knowledge gaps of the mothers improved significantly after counseling irrespective of their parity, education and location as seen by the increase in mean scores.Conclusions: Neonatal morbidity and mortality due to avoidable causes like hypoglycemia, hypothermia, sepsis can be achieved by practicing appropriate post-natal care practices. WHO recommendations on these practices should be widely propagated through frequent antenatal and post-natal counseling by health care workers.
      PubDate: 2021-11-23
      DOI: 10.18203/2349-3291.ijcp20214532
      Issue No: Vol. 8, No. 12 (2021)
       
  • Study of extrapulmonary tuberculosis in tertiary care hospital children
           with reference to cartridge based nucleic acid amplification test

    • Authors: Chirag Shah, Shantanu Jain, Pathik Patel
      Pages: 1947 - 1951
      Abstract: Background: Tuberculosis is an infectious disease cause by the mycobacterium tuberculosis which typically involve lung but can affect other site called extrapulmonary tuberculosis (EPTB). In EPTB lymph node tuberculosis is most common and most severe is tuberculous meningitis. Cartridge based nucleic acid amplification test (CBNAAT) have high sensitivity and perform both respiratory and non-respiratory specimen. The aim of this retrospective study is to find out the proportion of extra pulmonary tuberculosis in hospitalized patient and determine the association of CBNAAT in diagnosis EPTB and Rifampicin resistance.Methods: This is the retrospective observational study done at Civil Hospital Ahmedabad in between October 2017 to October 2019 among the admitted patient age 1 month to 12 year diagnosed cases of EPTB according to RNTCP guidelines. Data collection done by medical records as indoor case sheets and investigation data from laboratory department.Results: Incidence of EPTB among the hospitalized children is 1.95% and among total tuberculosis patient is 42.48%. Among 191 suspected EPTB cases 59 confirmed indicate sensitivity of 37.3% and no false positive cases indicate 100% positive predictive value. Sensitivity of CBNAAT was highest in gastric aspirate followed by CSF in present study.Conclusions: Tuberculosis is more common in male child less than 5-year-old with frequent risk factor is rural residential area, lower socioeconomic class and contact with active cases. In my study is CNS tuberculosis is most common. In my study mortality is higher among 1-to-5-year age group with co morbid condition are SAM and septicemia.
      PubDate: 2021-11-23
      DOI: 10.18203/2349-3291.ijcp20214533
      Issue No: Vol. 8, No. 12 (2021)
       
  • Parenting styles and social-emotional development of preschool children

    • Authors: Pooja A. Sukumaran, Bhavani B. Balakrishna
      Pages: 1952 - 1957
      Abstract: Background: A preschool aged child’s social emotional development can be influenced in many ways; one of which being the early style the parent uses to raise them. Identifying social emotional development in pre-schoolers by behaviours related, but not limited to: play, self-esteem, tantrums, interaction with people, disposition, transitions, are used to assess the child’s social emotional development. The purpose of this study was to examine the relationship between social emotional development of preschool children and parenting styles.Methods: A non-experimental survey design was adopted for the study. 200 parents having preschool children were selected by purposive sampling technique. Data were collected using a 5-point rating scale for identifying the parenting style. A 3-point rating scale was used to assess the social emotional development of preschool children.Results: Majority (88.5%) of the parents used authoritative parenting style, 8.5% used authoritarian parenting style and 3% used permissive parenting style. Majority of the children had near optimum social emotional development. The present study revealed that the correlation value between Social emotional development of preschool children and authoritative parenting style (r=0.286, p≤0.001) and authoritarian parenting style (r=0.452, p≤0.001) were highly significant at 0.001 level. There was no significant correlation between permissive parenting style and social emotional development of preschool children (r=0.052, p=0.461).Conclusions: The overall finding of the study showed that parenting style influenced the social and emotional development of preschool children. In this study majority of children had near optimum social and emotional development.
      PubDate: 2021-11-23
      DOI: 10.18203/2349-3291.ijcp20214534
      Issue No: Vol. 8, No. 12 (2021)
       
  • Clinicoetiological profile of urinary tract infection in pediatric
           population in a teaching hospital in south India

    • Authors: Poornima Venugopal, Carol Sara Cherian, Pooja Raghunath
      Pages: 1958 - 1964
      Abstract: Background: Urinary tract infection (UTI) is one of the most common bacterial infections seen in children. A wide range of organisms with varying antibiotic sensitivity patterns have been known to cause UTI. The objective of the study was to analyse the clinical presentation of UTI in children between 1-month to15 years of age and to analyse the causative microorganism and their drug susceptibility in UTI in children between 1 month to 15 years of age.Methods: A retrospective study was conducted in a teaching hospital in Kerala, between July 2018 and June 2020 among children 1 month to 15 years of age who presented with symptoms of UTI. Patients who had culture positive UTI were included in the study. Clinical data was obtained from inpatient and outpatient records. Antimicrobial susceptibility was done for positive urine culture by Kirby-Bauer disk diffusion method. Statistical analysis was done using Statistical package for social sciences (SPSS) software version 16.Results: Of the 1057 urine samples analysed, 18.44% had significant bacteuria. 43.07% were children less than one year of age with male predominance. Fever and dysuria were the most common clinical presentation. E. coli was the most prevalent pathogen isolated followed by Klebsiella pneumoniae. Enterococcus faecalis was the only gram-positive bacilli isolated. Highest resistance was shown to ampicillin, third generation cephalosporins and co-trimoxazole. Least resistance was shown to nitrofurantoin, fluoroquinolones, aminoglycosides, piperacillin- tazobactam and carbapenems.Conclusions: Regular surveillance programme is necessary for implementation of guidelines for empiric treatment of UTI.
      PubDate: 2021-11-23
      DOI: 10.18203/2349-3291.ijcp20214535
      Issue No: Vol. 8, No. 12 (2021)
       
  • Neurodevelopmental outcome of very low birth weight and extremely low
           birth weight newborn at 12 months of corrected age associated with
           prenatal risk factors

    • Authors: Balai Chandra Karmakar, Kausik Patra, Mrinmoy Bairagi
      Pages: 1965 - 1971
      Abstract: Background: Various neuro-developmental impairment (NDI) among very low birth weight babies (VLBW) and extremely low birth weight (ELBW) babies are common in Indian scenario. This study was designed to assess the impact between prenatal risk factors and neuro-developmental outcomes of premature infants.Methods: This descriptive study was conducted on 143 VLBW and ELBW babies admitted in SNCU of North Bengal Medical College, Darjeeling, West Bengal and discharged babies were followed up.Results: Total 143 neonates were studied among male 82 (57.3%) and female 61 (42.7%) and AGA: SGA ratio was 1.97. Birth weight ranged from 500 to 1500grams with mean was 1199.6±244.14 and the median was 1240 gm. The mean gestational age (Mean± SD) was 29.65±2.032 weeks with range 24-32 weeks and the median was 30 weeks. 28 (19.6%) had PIH, 39 (27.3%) had multiple gestation, 18 (12.6%) had perinatal infection and 25 (17.5%) had birth asphyxia. CRIB II score ranged from 3-18 with mean was 8.021±3.883 and median was 7. 73.4% (105/143) were discharged alive. Significant positive correlations were found among birth weight, gestational age, perinatal infection (p<0.001). Adverse neonatal outcome was associated with CRIB II score ≥10. Total CRIB II score with parameters of NDI like developmental delay, cerebral palsy, visual abnormality, absent ABR showed good correlation (p<0.001). Fisher Exact test revealed significant association between total score and Cerebral palsy (p=0.0005), visual abnormality (p=0.0005), absent ABR (p=0.0002).Conclusions: Perinatal risk factors influence future NDI in very low and extremely low birth weight babies. They should be identified and treated promptly to achieve good outcome. 
      PubDate: 2021-11-23
      DOI: 10.18203/2349-3291.ijcp20214536
      Issue No: Vol. 8, No. 12 (2021)
       
  • Clinical profile and outcome of multisystem inflammatory syndrome in
           children in a tertiary care centre of North Kerala: a prospective study

    • Authors: Naveena Sajeevan, Mohammed Manakkatt T. P., Kavitha Pavithran, Urmila Muraleekrishnan K. V.
      Pages: 1972 - 1976
      Abstract: Multisystem inflammatory syndrome in children (MIS-C) is a newly emerged disease following the outbreak of COVID-19. The nomenclature is given by WHO. Similar condition is named as paediatric inflammatory multisystem syndrome-temporally associated with SARS-CoV2 virus (PIMS-TS), by RCPCH. To study the clinical profile and outcome of MIS-C in 2 months to 18 years old. The 25 children, admitted in PICU and pediatrics ward were included in the study. The 79% required PICU admission and two required mechanical ventilation. One child expired. Children presented with conjunctival congestion (53%), diarrhoea (47%), cervical lymphadenopathy (37%), shock (31.5%), vomiting (36.8%), rashes (36.8%), mucosal erythema (36.8%), cough (10.5%) and headache (10.5%). Inflammatory markers were elevated in all the children. On initial echocardiography, 4 children (21%) had LV dysfunction with LVEF <50%. Six children (31.5%) were treated with IVIG and IV methylprednisolone, changed to oral prednisolone after 3 days and continued for 2 weeks. Three children (18%) were treated with IVIG and oral prednisolone. Two children (12%) were treated with IVIG alone. Eight children (47%) were treated with methylprednisolone alone. The median duration of hospitalisation was 5 days. 18 children (94.7%) were discharged to home within one week of admission. One 8 months old baby presented with shock, succumbed to death in spite of giving IV methyl prednisolone and IVIG. In our study we observed that early diagnosis and treatment with IVIG or steroids offers good outcome for the condition. Of the 19 children studied, 17 children were discharged within one week.
      PubDate: 2021-11-23
      DOI: 10.18203/2349-3291.ijcp20214537
      Issue No: Vol. 8, No. 12 (2021)
       
  • Neonatal hepatitis in a term newborn: sequelae to in utero COVID-19
           infection

    • Authors: Pushwinder Kaur
      Pages: 1977 - 1979
      Abstract: Neonatal hepatitis is a common disease entity seen among newborns. It is known as inflammation of liver parenchyma in newborns, specifically in first month of life. Most common cause of neonatal hepatitis is viral infection which infects liver in utero or in postnatal period. Newborns carrying neonatal hepatitis mostly present with jaundice, failure to gain weight and hepatosplenomegaly. Neonatal hepatitis due to in utero COVID infection is diagnosed by conjugated hyperbilirubinemia, raised SGOT and SGPT levels and raised COVID antibody levels.  Treatment includes addition of fat-soluble vitamins, phenobarbitone and supportive care. Here author is reporting a rare case of 11 days old newborn with neonatal hepatitis, who presented with severe jaundice (TSB/DB- 44/22) hepatosplenomegaly and hypoxemia with mild respiratory distress. Maternal history revealed high grade fever with low cell count during 5th month of gestation, though COVID RAT was negative and RT-PCR was not done. Baby was managed in NICU with IV antibiotics, IV fluids, oxygen by prongs, oral fat-soluble vitamin supplementation, adequate calorie intake and phenobarbitone. Baby responded very well to the treatment and discharged in healthy condition after 7 days. Paucity of data documenting in utero COVID-19 infection as cause of neonatal hepatitis led us to report this rare case.
      PubDate: 2021-11-23
      DOI: 10.18203/2349-3291.ijcp20214538
      Issue No: Vol. 8, No. 12 (2021)
       
  • X-linked agammaglobulinemia rare disease with a rarer presentation

    • Authors: Ramakrishna Myathari, Anand Gupta
      Pages: 1980 - 1983
      Abstract: X-linked agammaglobulinemia (XLA) is a rare disorder, characterized by absence of mature B cells leading to severe antibodies deficiency. This translates to recurrent sinopulmonary infections in affected children. The most common age group of presentation is 6 months to 2 years. Being an X-linked recessive disorder males are affected, females are carriers. Intravenous immunoglobulins and antibiotics remains the corner stone of treatment. Here in, we report a case of 11-year-old male having recurrent episodes of fever with one episode of hospitalization 3 years back. Child was treated at healthcare facility elsewhere for recurrent fever. He presented to our institute with signs and symptoms suggestive of meningitis, investigated, had culture proven Staphylococcus aureus meningitis with a low Absolute Lymphocyte Count (ALC). On further work up found to have low serum immunoglobulins (IgG, IgM, IgA) and Flowcytometry showing absence of B cells (CD19/CD20). Child was diagnosed to have XLA. This case highlights the importance of having strong clinical suspicion of XLA, despite not having recurrent sinopulmonary infections.
      PubDate: 2021-11-23
      DOI: 10.18203/2349-3291.ijcp20214539
      Issue No: Vol. 8, No. 12 (2021)
       
  • A rare presentation of systemic lupus erythematosus with lupus hepatitis

    • Authors: Sushrutha K. P., Thanuja Basavanagowda, Savitha M. R., Prashanth S., A. Ramu
      Pages: 1984 - 1986
      Abstract: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by multisystem inflammation and the presence of circulating autoantibodies directed against self-antigens. Prevalence of SLE in children and adolescents is 1-6 per 100,000 population. Liver dysfunction occurs in approximately in 50-60% of the patients with SLE.And the incidence of lupus hepatitis in diagnosed SLE patients is 9.3%. We are reporting a case of 11-year-old female child who presented with fever, skin rashes, oral ulcers, irritability and positive antinuclear antibody (ANA) with deranged liver function test (LFT) in the form of elevated transaminases, bilirubin level and altered coagulation profile. Hepatitis serology was negative, with low C3 levels, diagnosed as SLE with lupus hepatitis with lupus nephritis stage IV with psychosis. Clinical improvement along with improvement in terms of laboratory findings was seen on corticosteroids therapy. It is important to differentiate lupus hepatitis from autoimmune hepatitis (AIH) as AIH presents similar to lupus hepatitis, has poor prognosis. While lupus hepatitis being rare cause for mortality in patients with SLE has good response with early intervention with corticosteroids therapy.
      PubDate: 2021-11-23
      DOI: 10.18203/2349-3291.ijcp20214540
      Issue No: Vol. 8, No. 12 (2021)
       
  • Non-suicidal intentional ingestion of iron tablets and severe
           intoxication: the result of adolescent boy’s impulsive risky behaviour
           in the school

    • Authors: Krutika Rahul Tandon, Rahul Tandon, Amola Khandwala, Tanvi Mehta
      Pages: 1987 - 1989
      Abstract: Acute iron poisoning is a potentially fatal intoxication in children. As the Iron preparations are commonly administered to pregnant women, lactating mothers, toddlers, it is easily available at home. So younger children are prone to consume it accidently. Although iron is a therapeutic drug in recommended dosages, excessive iron in the free state can produce toxicity by affecting multiple cellular processes by catalysing redox reactions with lipid peroxidation and free radical formation. The severity of intoxication depends on the amount of elemental iron ingested. Serious toxicity is usually associated with a dose of >40 mg/kg of elemental iron. Levels more than 100 mg/kg are almost always fatal. We report a case where a 12-year male child intentionally taken 60 tablets of iron (ferrous fumarate) at his school as a part of competition or bet to other schoolmate and presented with acute iron poisoning with hepatic encephalopathy to us. Important initial laboratory parameters were AST-4,879 U/L, Prothrombin time-60 sec and Iron level-213 microgram/dl. With timely specific management i.e., deferoxamine infusion along with all required intensive care supportive management in PICU the patient was discharged successfully. We chose to report this case to highlight the risky behaviour of adolescence who usually grows physically and emotionally earlier but their prefrontal lobes are yet immature to take proper and correct decision. Thus, impulse activity may prove fatal for them.
      PubDate: 2021-11-23
      DOI: 10.18203/2349-3291.ijcp20214541
      Issue No: Vol. 8, No. 12 (2021)
       
  • An uncommon organism causing necrotizing pneumonia in a toddler

    • Authors: Manju Reka S. B., Arulkumaran Arunagirinathan, Anupriya Chandrasekaran, Yuvarajan S.
      Pages: 1990 - 1992
      Abstract: Necrotizing pneumonia (NP) is an uncommon complication of bacterial pneumonia in children, which must be looked into if a severe pneumonia has poor response to recommended antibiotics. The present case is a toddler with NP in whom fever and cough persisted despite treatment with first-line antimicrobial therapy, computed tomography (CT) scan revealed consolidation with multiple cavities, pseudomonas aeruginosa was the pathogen isolated from bronchoalveolar lavage, which a very uncommon organism is causing NP. Community acquired necrotizing pneumonia caused by pseudomonas is not reported in paediatric population. Hence, we report this case.
      PubDate: 2021-11-23
      DOI: 10.18203/2349-3291.ijcp20214542
      Issue No: Vol. 8, No. 12 (2021)
       
  • Compound heterozygous delta beta thalassemia with IVS 1-5 (G>C) mutation
           presenting as thalassemia major phenotype

    • Authors: Neha Goel, Kanika Kapoor, Srilatha Bajaj, Sumita Saluja
      Pages: 1993 - 1995
      Abstract: Delta beta thalassemia is an unusual variant of thalassemia with elevated level of fetal hemoglobin (HbF). Unlike beta thalassemia, delta beta thalassemia heterozygotes have milder phenotype and homozygotes present as thalassemia intermedia phenotype.  We report a 11-month-old male child who presented with severe anemia, and hepatosplenomegaly, thalassemia major phenotype. On evaluation was diagnosed as compound heterozygous for δβ0/β thalassemia with IVS 1-5 (G>C) mutation. This case highlights the importance of genotyping of patients with δβ thalassemia and co-inheritance of δβ thalassemia deletion with point mutation for β-thalassemia results in severe clinical phenotype as thalassemia major. 
      PubDate: 2021-11-23
      DOI: 10.18203/2349-3291.ijcp20214543
      Issue No: Vol. 8, No. 12 (2021)
       
  • Aerosolized type II transmembrane serine protease 2 inhibitor to combat
           COVID-19: a proposal

    • Authors: Chandan Raybarman, Surajit Bhattacharjee
      Pages: 1996 - 1997
      Abstract: Type II transmembrane serine protease (TMPRSS2) is expressed at the cell surface with COVID-19 infection. And COVID-19 infection misuse TMPRSS2 to advance their spread, making this protease potential focuses for intervention in COVID-19 infection. TMPRSS2 blocker may be the appropriate option to arrest cellular entry of COVID-19 by deregulating spike priming. Therefore a trial may be intended to watch the adequacy of aerosolized spraying of TMPRSS2 inhibitors to break the viral entry to the objective cells that empower to break the COVID-19 transmission. Targeting TMPRSS2 through aerosolized TMPRSS2 inhibitor is important to examine a possibly viable remedial technique in the treatment of COVID-19.
      PubDate: 2021-11-23
      DOI: 10.18203/2349-3291.ijcp20214544
      Issue No: Vol. 8, No. 12 (2021)
       
  • Atypical hand foot mouth disease presenting as vesiculobullous lesion

    • Authors: Nihil E. Lohidakshan, Chakravarthi R. Srinivas, Sruthi Alanghat
      Pages: 1998 - 1999
      Abstract: Hand, food, and mouth disease (HFMD) is a highly contagious disease caused by enteroviruses affecting young children under 5 years. Among enteroviruses (EVs), the main pathogens of HFMD are coxsackievirus A16 (CV-A16) and EV-A71 (EV-71).1 The clinical features include a prodromal phase which has low-grade fever, malaise and sore throat. This initial phase is usually followed by enanthem and erythematous papular skin lesions, predominantly affecting palms and soles. The dorsal surface of hands, feet, and perioral skin are rarely affected. Atypical HFMD presents as a widely distributed rash with varying morphology that makes clinical diagnosis and treatment challenging.2 Our objective is to present atypical cutaneous manifestations of HFMD caused by CA6.
      PubDate: 2021-11-23
      DOI: 10.18203/2349-3291.ijcp20214545
      Issue No: Vol. 8, No. 12 (2021)
       
 
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