Publisher: Medip Academy   (Total: 12 journals)   [Sort by number of followers]

Showing 1 - 12 of 12 Journals sorted alphabetically
Intl. J. of Advances in Medicine     Open Access   (Followers: 5)
Intl. J. of Basic & Clinical Pharmacology     Open Access   (Followers: 4)
Intl. J. of Clinical Trials     Open Access   (Followers: 5)
Intl. J. of Community Medicine and Public Health     Open Access   (Followers: 8)
Intl. J. of Contemporary Pediatrics     Open Access   (Followers: 11)
Intl. J. of Otorhinolaryngology and Head and Neck Surgery     Open Access   (Followers: 1)
Intl. J. of Reproduction, Contraception, Obstetrics and Gynecology     Open Access   (Followers: 17)
Intl. J. of Research in Dermatology     Open Access   (Followers: 1)
Intl. J. of Research in Medical Sciences     Open Access   (Followers: 7)
Intl. J. of Research in Orthopaedics     Open Access   (Followers: 1)
Intl. J. of Scientific Reports     Open Access   (Followers: 4)
Intl. Surgery J.     Open Access   (Followers: 5)
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International Journal of Basic & Clinical Pharmacology
Number of Followers: 4  

  This is an Open Access Journal Open Access journal
ISSN (Print) 2319-2003 - ISSN (Online) 2279-0780
Published by Medip Academy Homepage  [12 journals]
  • Antibiotic resistance in aerobic bacterial isolates from infected diabetic
           foot ulcers in North Eastern Tanzania: an urgent call to establish a
           hospital antimicrobial stewardship committee

    • Authors: Ahmed Shabhay, Pius Horumpende, Martin Mujuni, Edna Joy Munisi, Stephen Mshana, Zarina Shabhay, Andrew Mganga, Kondo Chilonga, David Msuya, Jaffu O. Chilongola, Jeff Van Baal, Samwel Chugulu
      Pages: 1163 - 1169
      Abstract: Background: Diabetic foot ulcers (DFU) is among major health problems which impact the socio economic burden globally. We aimed at assessing the susceptibility pattern of antimicrobials in DFU infections among patients admitted in the surgical department at Kilimanjaro Christian Medical Centre (KCMC).Methods: This descriptive cross-sectional study was conducted from September 2018 through March 2019. Pus swabs were collected on the first day of admission by deep wound swabbing after irrigation with normal saline solution. Kirby-Bauer method was done according to the Clinical and Laboratory Standard Institute (CLSI) guidelines.Results: Sixty diabetic ulcer patients had 62 bacterial isolates. Majority of the isolates were gram negative 49/62 (79.03%). The most common isolate was Escherichia coli 15/62 (24.19%) followed by Pseudomonas aeruginosa 14/62 (22.58%), Proteus mirabilis 8/62 (12.9%) and Staphylococcus aureus 5/62 (8.06%). Klebsiella pneumoniae, coagulase negative Staphylococcus, Proteus vulgaris, and Streptococcus pyogenes each contributed 4/62 (6.25%) isolates. Of the 49/62 (79.3%) gram negative isolates, 8/49 (16.33%) were mono resistant, 30/49 (61.22%) were multiresistant, and 11/49 (22.45%) were susceptible. Of the multi-resistant isolates, E. coli 12/15 (80.00%), and P. aeruginosa 7/14 (50.00%) were predominant. A total of 39/62 (62.90%) isolates in patients contributed to poorer outcomes including loss of body part. Patients with ulcers infected by P. aeruginosa 11/39 (28.21%) had the highest number of surgical removal of body parts followed by E. coli 8/39 (20.51%). Gram negative bacteria were highly susceptible to amikacin 91.18%, meropenem 93.33% and imipenem 95.24%. Isolates susceptibility to ceftriaxone was 32%.Conclusions: Amikacin, meropenem and imipenem can be safely used as broad-spectrum antimicrobials in DFU. The standard of care remains culture and sensitivity of isolated microorganisms in combating diabetic foot ulcers infections.
      PubDate: 2021-09-23
      Issue No: Vol. 10, No. 10 (2021)
  • Assessment of safety and efficacy of a dietary supplement KaraLiv™ in
           supporting liver health: a double-blind, parallel, placebo-controlled
           randomized clinical trial

    • Authors: Krishna Rajendran, Rajendran Ramaswamy, Kudiganti Venkateshwarlu, Ravikumar Rajendran, K. Sunil Naik
      Pages: 1170 - 1181
      Abstract: Background: The liver is responsible for many critical functions within the body. If the liver becomes diseased or injured, loss of those critical functions can cause significant damage to the body. KaraLivTM is a novel herbal formulation which contains a blend of different herbal extract ingredients. The current study tested the safety and efficacy of KaraLivTM versus a placebo control in supporting liver function.Methods: The study is a randomized, double-blind, parallel, and placebo-controlled study. A total of 60 patients were divided into 2 groups of 30 each. One group was given KaraLivTM and the other group was given a placebo for a period of 56 days. Treatment results were assessed by evaluating the levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), bilirubin, and alkaline phosphatase (ALP) in both groups.Results: The herbal supplement KaraLivTM significantly supported healthy liver function compared to the placebo following the 56 days of treatment. The treatment (KaraLivTM) group showed a statistically significant improvement in assessed liver enzyme levels compared to the placebo group.Conclusions: The all-natural herbal supplement KaraLivTM is a safe and effective product that can significantly help support healthy liver function.
      PubDate: 2021-09-23
      Issue No: Vol. 10, No. 10 (2021)
  • An observational study on Awareness of Teratogenic drugs among
           Undergraduate Medical Students from two medical institutes of Central

    • Authors: Devendra Singh Kushwah, Beenu Kushwah
      Pages: 1181 - 1185
      Abstract: Background: Teratogenicity caused by drugs can be avoided to major extent just by creating more awareness about rational use of drugs among treating doctors. Deleterious effects of a drug upon developing foetus are directly related with the stage of embryological development at the time of exposure. Attainment of right knowledge at right time about teratogenicity of a particular drug is very crucial which requires more awareness among general doctors in a country like India where most of the pregnant females are manged by these doctors only in peripheral regions. Present study was an observational study to assess basic knowledge of undergraduate medical students regarding teratogenicity in order to make necessary changes in existing mode of training of this particular topic.Methods: Present study was a questionnaire based cross sectional observational study to assess basic knowledge of undergraduate medical students regarding different aspects of teratogenicity. It included 250 students of two medical colleges of central India.Results: Out of 250 students 146 students reported on time. Maximum students (71%) were aware about the teratogenicity property of certain harmful drugs. Although 90% of students knew that early first trimester is the most susceptible time, only 21% could state the importance of doing counselling regarding use of drugs even before pregnancy.Conclusions: Based on the findings of present study it is obvious that more emphasis should be put on improving knowledge about teratogenic drugs during early years of medical training in order to bring about necessary changes in existing practices of treating doctors.
      PubDate: 2021-09-23
      Issue No: Vol. 10, No. 10 (2021)
  • Comparative analysis of efficacy and tolerability of tramadol versus
           diclofenac in treatment of knee osteoarthritis

    • Authors: Rima Kanjiya, Ravi Kotadia
      Pages: 1186 - 1190
      Abstract: Background: Present study was conducted on patients of osteoarthritis (OA) treated with the traditional drug diclofenac sodium and compares it with tramadol, with the primary objective for determining effectiveness and tolerability based on WOMAC scores.Methods: The study was conducted as a randomized clinical study of the effectiveness and tolerability of tramadol versus diclofenac in the treatment of knee OA, at Tertiary care institute of Gujarat in the department of orthopedics. Consecutive patients were allotted serially in two groups; tramadol group (n=75) One tablet orally twice daily for 8 weeks. Diclofenac group (n75) patients received 75 mg oral dose of diclofenac 2 times daily for a period of 8 weeks. Overall improvement was evaluated through various parameters.Results: About 33% decrease in the scoring of stiffness domain of the WOMAC OA index questionnaire in the tramadol group and a 21% decline in the diclofenac group was observed. There was a 65% decrease in the scoring of knee joint tenderness questionnaire in the tramadol group and a 44% reduction in the diclofenac group. Tramadol was found to be more effective in improving the WOMAC OA index. WOMAC score (overall) and knee joint tenderness scores were also improved by tramadol than diclofenac.Conclusions: There was a significant improvement in the standard of life in patients suffering from knee OA when treated with tramadol. Tolerability was better with tramadol than diclofenac.
      PubDate: 2021-09-23
      Issue No: Vol. 10, No. 10 (2021)
  • A perceptional analysis of online and offline mode of lectures in second
           year undergraduate medical students at SMIMER medical college, Surat

    • Authors: Antra M. Patel, Kirti Saxena, Arvind Singh Panwar
      Pages: 1191 - 1195
      Abstract: Background: The COVID-19 pandemic demanded lockdown to control the spread of disease, inevitably medical colleges are also affected and online mode of teaching has become a solution for continuity of teaching in medical colleges. The main purpose of study to identify perception of medical students towards online and offline mode of lectures by parameters as follows: knowledge, understanding, skills and methodology.Methods: This was a prospective, cross-sectional study with duration of three months. A well- articulated set of questionnaires based on knowledge, understanding, skills and methodology parameters will be circulated among the second-year undergraduate medical students from SMIMER, Surat.Results: About 82% of the students perceived that offline mode of lectures provide more information of subject and helps with better retention of knowledge. Only 21.5% students were in favour of online mode for being able to understand lecture content. For the development of the practical skills and clinical training, 97% of the participants favoured offline mode. However, 67% of the participants believe online mode of lectures save their time and work well with their schedule.Conclusions: Majority of students perceived that offline mode of lectures provide more information of subjects and better retention of knowledge. According to them offline mode of lectures is easy to understand and improved conceptual thinking. For development of clinical and practical skills offline mode of lectures is mandatory. But, majority of students perceived that online learning provide flexibility in participation of lectures and time saving method.
      PubDate: 2021-09-23
      Issue No: Vol. 10, No. 10 (2021)
  • Study on drug profile used in common pregnancy influenced issues and its

    • Authors: Semmalar G. V., Kaviya Anisha S. J., Terry Sheetal B., Saravanakumar R. T., Latha K.
      Pages: 1196 - 1201
      Abstract: Background: Pregnancy influenced issues are common among pregnant women treated by medications that causes complication in mother and fetus. The study aims to identify patients with pregnancy influenced issues like gestational diabetes mellitus, gestational hypertension, gastroesophageal reflux disease and anaemia. To assess the drug used pattern along with antibiotic therapy and to observe the above disease related complications.Methods: A hospital based prospective observational study was conducted at department of obstetrics and gynecology in Rajah Muthiah Medical College and Hospital. Totally 100 patients enrolled and data was collected using data collection form.Results: Out of 100 patients, high prevalence occurred in 26-30 years of age. Primarily gestational hypertension (39%), treated with Tab. Labetatol and complications were premature delivery, low birth weight. Anaemia (25%) cases treated with Tab. Ferrous sulphate, Iron sucrose and Folic Acid, Preterm delivery as complication. Gestational diabetes mellitus (18%) treated with Metformin and Human Insulin and complications were preterm delivery, maternal obesity, increased child weight. GERD (8%) treated with Pantoprazole, Ondansetron, Bifilac and complications were weight loss, dehydration, low birth weight. In pre-operative cases, 79% received antibiotics as monotherapy and 21% as dual therapy. In post-operative cases, 41% received antibiotics as monotherapy and 59% as dual therapy. Metronidazole (95%) given in both post and pre- operative conditions.Conclusions: The present study provides valuable insight about the overall drugs used in pregnancy related diseases and complications arise. We hope our data will make necessary recommendations to all health care professionals and pregnant women to ensure all pregnancy related safety measures were taken.
      PubDate: 2021-09-23
      Issue No: Vol. 10, No. 10 (2021)
  • Online learning during COVID-19 pandemic - a cross sectional survey of
           students’ perception

    • Authors: Vemuri V. Rani
      Pages: 1202 - 1208
      Abstract: Background: The corona virus pandemic had an impact on the student’s education especially the medical and dental students. There was no option but to continue the education by using the online platforms to take lectures. This survey aims at finding out the students’ perception towards these online classes.Methods: After ethics committee approval, a pre-validated questionnaire was administered as a Google form to the first, second bachelor of medicine and bachelor of surgery (MBBS) students and first, second bachelor of dental surgery (BDS) students, data was analyzed using descriptive statistics in Microsoft excel.Results: Out of 400 students who were sent the questionnaire 169 answered, with a response rate of 42.25%. 43 (25.44%) students had responded that the availability of the PowerPoint presentation for future reference makes it better for their study. 59 (34.91%) students said the main problem with the online lectures was Internet connectivity and technical issues /buffering during the class. Mean was 3 and above for three questions regarding the interaction during online classes and missing face to face interaction with both faculty and students.Conclusions: There is a positive attitude towards online learning, but the students miss the face-to-face interaction with the faculty and students. There is a necessity for improving the required infrastructure as well as training the faculty for the use of online platforms for planning and undertaking the sessions in an interactive way keeping in view the future occurrence of similar situations.
      PubDate: 2021-09-23
      Issue No: Vol. 10, No. 10 (2021)
  • An observational comparative study of intraocular pressure changes in
           post-operative cataract patients treated with dexamethasone, difluprednate
           and prednisolone in a tertiary care centre

    • Authors: Sadhana K. Hingorani, Anupama S. Desai, Manisha B. Shastri
      Pages: 1209 - 1214
      Abstract: Background: Cataract is opacity of lens which is treated surgically. Topical corticosteroids are routinely used in the treatment of post-operative inflammation following cataract surgery. This study aims to compare the intraocular pressure changes caused by various topical steroids (prednisolone, dexamethasone and difluprednate) in post cataract patients. To compare compliance and to detect any significant adverse effects.Methods: Patients admitted in ophthalmology department for cataract surgery operated by phacoemulsification were taken as subjects. Total number of patients enrolled in the study were 354. Subjects were separated into 3 groups depending on topical steroids which were prescribed after surgery: group 1 - difluprednate, group 2 -dexamethasone and group 3 - prednisolone. Changes in intraocular pressure (IOP) of patients were measured by ophthalmology department preoperatively and postoperatively after 1st, 2nd, 3rd, 4th week of surgery. These data were collected and analysed. Adverse effects, Compliance of patients and number of bottles of drug used after surgery were also noted.Results: On comparing IOP, there was significant variation (p<0.027) between 3 drugs after one week of drug administration. When group 1 was compared with group 2 or group 3 there was no significant difference Average cost of difluprednate is about 3 times higher than the cost of dexamethasone or prednisolone.Conclusions: All the three topical steroids cause a rise in intraocular pressure in post cataract patients. But in group 1 (difluprednate) there was a rise in IOP up to three weeks after surgery but after 3rd week IOP remained stable. Adverse effects were seen more in group 2 and group 3. 
      PubDate: 2021-09-23
      Issue No: Vol. 10, No. 10 (2021)
  • Monoclonal antibodies in COVID-19 management: a scoping review

    • Authors: Umayal Adaikkalavan, Jeeja Mathummal Cherumanalil, Salwa Pannikkottuthodi, Hasna Poovancheri
      Pages: 1215 - 1220
      Abstract: Coronavirus disease 2019 (COVID-19) was declared as pandemic on March 11th 2020 by the world health organization (WHO). Vaccination is for preventing COVID-19 morbidity but when people are infected, treatment is required and even after one and half years the effective cure is yet to be discovered. In this context monoclonal antibodies (mAbs) are promising innovative therapeutic agents in controlling COVID-19 infection. Researchers have found more than 50 mAbs against COVID-19 and they are at different stages of development.  Scientists are pacing the research on mAbs. mAbs are innovative therapeutic agents in this context a scoping narrative review was done. At present we have evidences from numerous randomized controlled trials (RCT) on mAbs in effective control of respiratory and coagulation related complications due to COVID-19 infection. Many have got emergency use approval and few of which were withdrawn due to absence of enough evidences or adverse reactions. Examples are bamlanivimab, etesevimab, casirivimab and imdevimab. Other than these many investigational (mAbs) are under scrutiny. With the current evidences the article will give an insight to new and repurposed mAbs which are still under investigation in the management of COVID-19 infections.
      PubDate: 2021-09-23
      Issue No: Vol. 10, No. 10 (2021)
  • Berbamine application beyond cancer

    • Authors: Navneet O. Soni
      Pages: 1221 - 1226
      Abstract: The main purpose of this review was to ascertain the clinical application and future non oncological uses of Berbaminebamine (BERBAMINE). Berbaminebamine, as a STAT3 (signal transducer and activator of transcription) inhibitor, antioxidant, anti-inflammatory and modulator of many signalling pathways, should be investigated in autoimmune diseases.  Berbaminebamine has been found to have pharmacological activity in the following cancers: breast cancer, lung cancer, prostate cancer, pancreatic cancer, ovarian cancer, glioblastoma, colon cancer, bladder cancer, chronic myeloid leukemia, hepatocellular carcinoma, triple negative breast cancer and osteosarcoma. Ischemic reperfusion injury, melanoma, COVID-19 and allergy diseases are among the conditions for which it is beneficial. It may aid in the treatment of obesity, metabolic syndrome, inflammatory syndrome, sepsis, COVID-19, dengue fever, Nipah virus infection, influenza, solid tumors, lymphoma, cancer, hematological malignancies, skin inflammatory disorder and atopic dermatitis.  BERBAMINE can be used as versatile molecule in alcoholic liver disease, diabetic nephropathy and antiviral, anti-inflammatory.
      PubDate: 2021-09-23
      Issue No: Vol. 10, No. 10 (2021)
School of Mathematical and Computer Sciences
Heriot-Watt University
Edinburgh, EH14 4AS, UK
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