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Journal of Experimental and Clinical Medicine
Journal Prestige (SJR): 0.113
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  This is an Open Access Journal Open Access journal
ISSN (Print) 1309-4483 - ISSN (Online) 1309-5129
Published by Ondokuz Mayıs University Homepage  [3 journals]
  • The prevalence of TPH1 and TPH2 genetic polymorphisms susceptible to
           irritable bowel syndrome (IBS) among unrelated, healthy Malays in Malaysia

    • Authors: Rasmaizatul Akma ROSDİ; Nurfadhlina MUSA, Zalına ZAHARI, Mohd Khairi ZAHRİ @ JOHARİ, Mulham ALFATAMA, Boon Yin KHOO
      Abstract: Tryptophan hydroxylase (TPH) gene which encodes the first rate-limiting enzyme in the serotonin biosynthesis pathway is one of the leading candidate genes in the etiology of the most common gastrointestinal (GI) disease, the irritable bowel syndrome (IBS). The SNPs in the gene would distract the serotonergic function which led to the susceptibility to the syndrome. This study is aimed to determine the genotype distributions and allele frequencies of the three SNPs from two TPH genes; TPH1 and TPH2 genes among healthy, unrelated Malays in Malaysia. Nested-multiplex-allele specific PCR (NMAS-PCR) was subjected to 404 archived Malays’ DNA to genotype rs211105, rs4537731 and rs4570625 variants following the validation of genotyping results obtained through the direct Sanger sequencing. Results showed the genotype frequencies of AA in rs211105 and rs4537731 among Malays was 59.2 and 51.5%. The heterozygous of GT was found to be slightly higher than GG with 47.5 to 43.3% in rs4570625. Meanwhile, the mutant allele frequencies of rs211105 (G) and rs4537731 (T) were considerably comparable with 30.3 to 33.0% accordingly. Concurrently, no departure of HWE was detected except in rs4537731. This study described low frequencies of TPH1 and TPH2 SNPs mutant variants associated with the IBS among unrelated, healthy Malays. Data generated from this study is important to enhance our knowledge on the association of IBS pharmacogenetic profiles and the ethnic differences. Future studies on Malaysian IBS patients are recommended to determine the influence of rs211105, rs4537731 and rs4570625 to the syndrome locally.
      PubDate: Sat, 29 Oct 2022 00:00:00 +030
  • Effect of irisin on the epilepsy induced by penicillin G: An
           electrophysiological study

    • Authors: Yasemin ŞAHİN YILDIZ; Şerif DEMİR, Ersin BEYAZÇİÇEK, Ali GÖK, Özge BEYAZÇİÇEK
      Abstract: Epilepsy is a neurological disease characterized by sudden and synchronized seizures caused by abnormal and excessive electrical discharges in brain neurons. The purpose of this study was to electrophysiologically examine the effects of acute administration of irisin, which is thought to be neuroprotective and increase cell proliferation, at different doses (10 and 100 nM) on the penicillin-induced experimental epilepsy in rats. Forty-nine adult male Wistar rats were used in the study. The rats were divided into 7 groups: sham, control group (penicillin), irisin group, the pre- and during-seizure groups of 10 nM and 100 nM irisin. All the substances except penicillin were administered intraperitoneally. The rats were anesthetized using urethane. The bone tissue on the left cerebral cortex was removed and the electrodes were placed in the somatomotor cortex. Thirty minutes before penicillin administration, irisin was administered to the pre-seizure penicillin group at doses of 10 nM and 100 nM. Then, penicillin (500 IU/2 µl) was injected intracortically, and ECoG recording was continued for 120 minutes. On the other hand, 10 nM and 100 nM of irisin were administered to the during-seizure penicillin group after penicillin was injected intracortically and the seizure occurred, and ECoG recording was continued for 120 minutes. The ECoG recordings were analyzed using the PowerLab Chart v.8 software. In conclusion, it was found that irisin prolonged the latency of initial epileptic activity and decreased the number and amplitude of spike-waves in the penicillin-induced experimental epilepsy model. These results suggest that irisin might have an antiepileptic potential.
      PubDate: Sat, 29 Oct 2022 00:00:00 +030
  • Study of Bacteria Isolated from COVID-19 and Non-COVID-19 Intensive Care
           Units and Determination of Their Antibiotic Susceptibility Profiles

    • Authors: Çetin KILINÇ; Nilay COPLU, Melike YAŞAR DUMAN, Büşra ÇALIŞIR, Enis Fuat TÜFEKCİ, Muhammet GÜLHAN, Ayşe YILMAZ, Veysel Garani SOYLU
      Abstract: Nosocomial infections are infections that occur 48-72 hours after hospitalization, especially caused by bacteria, and pose a high risk for patients in the intensive care units (ICUs), including Covid-ICU. This study was aimed to reveal the distribution and antibiotic susceptibility profiles of bacteria isolated from various clinical samples of non-Covid-ICU and Covid-ICU patients. Bacterial strains isolated from ICUs patients in Kastamonu Training and Research Hospital between March 2020 and October 2020 were included in this study. The identification of the strains was carried out using the Vitek 2 compact automated system (BioMerieux, France) as well as standard microbiological methods. Antibiotic susceptibility tests were studied using the Vitek 2 automated system and the results were interpreted based on the European Committee for Antimicrobial Susceptibility Tests (EUCAST) guideline. There were 302 patients in the non-Covid-ICU and 440 patients in the Covid-ICU. A total of 470 strains, 370 from non-Covid-ICU and 100 from Covid-ICU, were isolated. Acinetobacter spp was the most frequently isolated species for both ICUs. Acinetobacter spp isolated from non-Covid-ICU had higher resistance rates to meropenem (p= 0.043), ceftazidime (p= 0.014), and levofloxacin (p=
      PubDate: Sat, 29 Oct 2022 00:00:00 +030
  • Lung Ultrasound in the Follow-up of Stable Idiopathic Pulmonary Fibrosis

    • Authors: Oya BAYDAR TOPRAK; Ezgi ÖZYILMAZ, İsmail HANTA, Sedat KULECİ, Efraim GÜZEL
      Abstract: Aim: Idiopathic pulmonary fibrosis is the most common and severe form of idiopathic interstitial pneumonia and is responsible for 20% of interstitial lung disease (ILD) cases. In this study, it was planned to evaluate the relationship of these two methods in detecting lung changes in IPF using a 12-zone lung ultrasound protocol with the current standard evaluation method, high-resolution computed tomography.Method: 22 patients diagnosed with idiopathic pulmonary fibrosis by multidisciplinary evaluation were included in the study and HRCT and pulmonary functional tests and LUS protocol of 12 lung regions were used.Results: The mean age ± SD of the patients was 69.0 ± 7.59 years. 21 (95.5%) were male. While 17 (77.3%) of the patients included in the study were diagnosed with radiological evidence, the diagnosis of the rest was confirmed histopathologically. While 5 of the patients (22.7%) did not receive any special treatment, 13 of the remaining patients were taking pirfenidone and 4 were taking nintedanib. When the HRCT total fibrotic score was evaluated with the total LUS score, a correlation coefficient of 0.702 (P:0.000) was obtained.Conclusion: In stable idiopathic pulmonary fibrosis, lung ultrasonography can be a readily accessible, non-irradiating, short-term, and rapidly informative monitoring technique that can be utilized at the bedside or during consultation instead of high reolution thorax computerized tomography.
      PubDate: Sat, 29 Oct 2022 00:00:00 +030
  • Miscarriage in a patient with Glanzmann Thrombasthenia and low ovarian
           reserve: a case report

    • Authors: Işılsu Ezgi ULUIŞIK; Mert SONKAYA, Nur DOKUZEYLÜL GÜNGÖR
      Abstract: Glanzmann thrombasthenia (GT) is an autosomal recessive hemorrhagic disorder mostly complicated by mucocutaneous bleeding. The severity of this bleeding disorder varies from mild bruising to frequent severe bleeding. Prepartum, peripartum and postpartum bleeding risks are increased in these patients. In addition to the hemorrhagic complications which endanger maternal and fetal wellbeing, the risk of miscarriage is increased due to maternal antibodies to the platelets which are also found on conceptus-derived trophoblast (placental) cells. This case report is about a patient with GT, complicated by infertility, low ovarian reserve, HPV positivity and bilateral dermoid cyst, who had a miscarriage in 7+1 week.
      PubDate: Sat, 29 Oct 2022 00:00:00 +030
  • Evaluation Of Mammographic Features In Women With Adenomyosis

    • Authors: Nezaket KADIOĞLU; Ayçağ YORGANCI, Harika GÜMGÜMCÜ, Mahmut Kuntay KOKANALI, Şebnem ÖZYER, Yaprak ÜSTÜN
      Abstract: AbstractAim: This study aimed to investigate the mammographic features in women with adenomyosis to determine the relationship between adenomyosis and breast disease. Methods: In this study, the mammographic features of women with adenomyosis were recorded. For the control group, women who had mammography without any gynaecologic complaints and with normal pelvic ultrasound were selected. Results: The adenomyosis group had higher breast density, more micro and macro calcifications, and higher BIRADS-mammography classification than the control group. When patients with low mammographic density (Density A - B, n = 80) and high mammographic density (Density C - D, n = 60) were compared, there were no statistically significant differences between the groups except the presence of adenomyosis. When patients were compared according to the BIRADS 1 - 2 (n=114) and BIRADS 3 - 4 (n=26) category, age ≥ 49.5, gravidity ≥ 3, parity ≥ 2, and the presence of adenomyosis were significantly higher in the BIRADS 3 - 4 category. In the logistic regression analysis, the presence of adenomyosis was found to be the sole factor for BIRADS 3-4 category. Conclusion: The results of our study suggested that patients with adenomyosis have an increased risk of higher mammographic breast density and BIRADS 3 classification.
      PubDate: Sat, 29 Oct 2022 00:00:00 +030

    • Authors: Recep ERİN; Yeşim BAYOĞLU TEKİN, Hatice KÜÇÜK, Özcan EREL
      Abstract: Objective: Dynamic thiol disulfide homeostasis (TDH) is critical in cervical carcinogenesis at HPV infection as a sign of antioxidant consumption native and total thiol levels decrease in progress to cervical intraepithelial lesions. TDH is the main actor in signaling pathways, apoptosis, antioxidant and detoxification reactions. In this study, we aimed to evaluate the effect of TDH intraepithelial progression of cervical precancerous lesions on HPV positive women.Methods: This was a prospective cross-sectional study. Subjects were selected from newly diagnosed high risk HPV DNA-positive patients. TDH results were calculated as the levels of disulfide, native and total thiol, the ratios of disulfide/total thiol (SS/SH+SS), disul-fide/native thiol (SS/SH) and native thiol/total thiol (SH/SH+SS).Results: A total of 146 women were included in the study. Study groups were as group one; control included 66 participants, group two; HPV DNA-positive women without preinvasive cervical lesion included 30 participants and group three; HPV DNA-positive women with preinvasive cervical lesion included 50 participants. Native and total thiol levels were ele-vated on HPV-positive women without preinvasive cervical lesions. There were no signifi-cant differences between groups related to the ratios of SS/SH, SS/ Total SH, SH/ Total SH levels. Conclusions: HPV infection related to oxidative stress has effects on oxidant/antioxidant balance and could be demonstrated in systemic circulation by TDH parameters. Consump-tion of thiol substances play role in the cervical neoplastic process, replacement with antiox-idants would be a treatment option for HPV infections.
      PubDate: Sat, 29 Oct 2022 00:00:00 +030
  • Comparison of diadynamic current, interferential current and
           transcutaneous electrical nerve stimulation therapies in patients with
           chronic low back pain

    • Authors: Alper UYSAL; Murat GÜNTEL
      Abstract: The aim of this study is to compare the effects of diadynamic current (DDT), interferential current (IFT) and transcutaneous electrical nerve stimulation (TENS) therapies on pain and disability levels in patients with chronic low back pain (CLBP). Patients with chronic low back pain between the ages of 18-65 were included in the study. The patients were divided into 3 groups. The first group received DDT, the second group IFT, and the third group TENS. The patients were evaluated in terms of pain and disability levels before the treatment, at the 0th day after the treatment, and at the 1st month after the treatment. Thus, these three treatment modalities were compared in terms of their effectiveness. A total of 83 patients were included in the study. There was no statistically significant difference between the groups in terms of age, gender, BMI, disease duration, pain, and disability levels of the patients before treatment. A statistically significant difference was found between the 0th day before and after the treatment and the 1st month before and after the treatment in terms of pain and disability levels in all three groups. The VAS scores of the individuals in the IFT group were significantly lower on the 0th day and 1st month after the treatment than in the DDT and TENS groups. Although there was no statistically significant difference, when looked clinically, the RMDQ scores of the individuals in the IFT group tended to decrease more than those in the DDT and TENS groups. All three treatment modalities are effective in patients with CLBP. However, IFC seems to be superior.
      PubDate: Sat, 29 Oct 2022 00:00:00 +030
  • Comparison of the treatment effects of extracorporeal shock wave therapy
           and trigger point injection in myofascial pain syndrome

    • Authors: Alper UYSAL; Murat GÜNTEL
      Abstract: Myofascial pain syndrome (MPS) is a common chronic musculoskeletal disease and the lifetime prevalence is about 85%. Comparison of the effects of ESWT (extracorporeal shock wave therapy) and trigger point injection (TPI) treatments on sleep quality in myofascial pain syndrome has rarely been studied. The aim of this study was to compare the effects of TPI + Dry Needling (DN) and ESWT treatments on pain, neck disability level, and sleep quality in patients with myofascial pain syndrome. 63 patients diagnosed with myofascial pain syndrome were included in the study. The patients were divided into two groups. ESWT was given to 32 patients and TPI to 31 patients. These two treatment regimens were compared in terms of pain (VAS), sleep quality (PSQI), and neck disability (NDI). In terms of mean VAS, NDI, and PSQI values, there was no statistically significant difference between the groups in the mean of pre-treatment, post-treatment day 0, and post-treatment 1 month. A similar and significant improvement was observed in both groups in terms of the evaluated parameters and based on our results, we can recommend both treatment options to MPS patients.
      PubDate: Sat, 29 Oct 2022 00:00:00 +030
  • Stem Cell and Biomaterials

    • Authors: Rukiye DEMİR
      Abstract: Stem cells are cells that are not yet differentiated, can divide asymmetrically, differentiate into different cell types, and perform functional tissue repair. They are recognized as major cellular candidates for the regeneration of damaged tissues. Biomaterials and biomaterial scaffolds are very important in tissue engineering applications using stem cells. Recently, studies examining stem cell biomaterial interactions in different aspects have attracted attention. In this review, current information about the general properties of stem cells and biomaterials, stem cell-biomaterial interactions, three-dimensional (3D) tissue scaffolds used in stem cell studies and 3D bioprinting are given.
      PubDate: Sat, 29 Oct 2022 00:00:00 +030
  • Risk factors associated with the development of trocar site hernia after
           laparoscopic bariatric-metabolic surgery

    • Authors: Muzaffer AL
      Abstract: The aim of this study investigate the effects of three laparoscopic bariatric-metabolic surgery (BMS) techniques [sleeve gastrectomy (SG), SG with transit bipartition (SG-TB), one anastomosis gastric by-pass (OAGB)] and patients’ sociodemographic and clinical features on trocar site hernia (TSH) development after laparoscopic BMS. This was a retrospective study conducted between January 2015 and February 2022. A total of 54 obese patients, 18 who developed TSH and 36 who did not develop TSH during follow-up after laparoscopic BMS, were included in the study. Mean age was 55.28 ± 7.98 years in the TSH group and 40.58 ± 11.47 years in the non-TSH group (p < 0.001). Seventeen (94.4%) of the TSH group and 23 (63.9%) of the non-TSH group were females (p = 0.021). TSH developed in 1 patient who underwent SG (5.6%), 1 patient who underwent OAGB (5.6%), and 16 patients who underwent SG-TB (88.9%). Multiple logistic regression analysis revealed that high age (p=0.018) and undergoing SG-TB (p=0.018) were independently associated with TSH development. In order to reduce TSH risk and to increase the chance for early diagnosis in patients with advanced age or SG-TB recipients, we believe that taking additional intraoperative precautions and performing closer follow-up will be necessary.
      PubDate: Sat, 29 Oct 2022 00:00:00 +030
  • Sex and Age-Dependent Changes of the Cerebral Cortex in Young Adult
           Sudanese: A Brain Segmentation Study

    • Authors: Wegdan AHMED
      Abstract: Introduction: The present study aims to measure the cortical structures of cerebral hemispheres including cortical thickness (CT) grey and white matter volume (GMV and WMV) and volume fraction (GMVF and WMVF), in addition to the volume (V) and cortical area pial (CAP) in normal young adult Sudanese, to investigate the effect of sex and age on these cortical structures.Material and Methods: The study included 139 healthy young adult Sudanese subjects (80 males and 59 females). Participant's ages were ranging from 20-40 years. T1-weighted MR brain images with a thickness 1mm were obtained. MR images of the subjects were analyzed using the automatic segmentation software (BrainSuite). Cortical structures of the cerebral hemispheres were estimated using the output data of the process of the software.Result: Sex differences were noticed in the GMV (325.76±38.74cm3), WMV (182.09±26.70cm3), V (507.85±62.20cm3), and CAP (1263.22±127.42cm2) of the cerebral hemisphere (P0.05). Changes with age were seen in the GMV, GMVF, WMVF, and CAP of the cerebral hemisphere (P0.05).Conclusion: Sex and age are important factors to consider when evaluating the cortical structures of the cerebral hemisphere. Sex affects GMV, WMV, V, and CAP; but not on the CT, WMVF, and GMVF. Age affects GMV, CAP, WMVF, and GMVF; but not on the CT, V, and WMV.
      PubDate: Sat, 29 Oct 2022 00:00:00 +030
  • The Role of Alveolo-Arterial Oxygen Gradient and Pneumonia Severity Index

    • Authors: Hale KEFELİ ÇELİK; Zahide DOĞANAY, Tuğçehan SEZER AKMAN
      Abstract: Purpose of the study is to determine the success rates of alveolo-arterial oxygen gradient (AaDO2) and the pneumonia severity index (PSI) in predicting mortality for the patients diagnosed with COVID-19 pneumonia. This retrospective study included patients who were treated with the diagnosis of COVID-19 pneumonia in the ICUs. Demographic characteristics, arterial blood gas values, radiological images and laboratory data of the patients were used through the hospital database and patient files. Group I patients consist of alive and Group II patients consist of deceased persons. 150 of 263 patients included in this study are in Group I and 113 are in Group II. RT-PCR test was positive in 20.9% of the patients. The most common symptom was dyspnea with 76.5% and the most common additional disease was hypertension with 58.1%.65% of patients had radiological involvement in both lungs, and the most common finding was the ground-glass opacity at 70.7%.In predicting mortality, PSI value was 135 in group I and 174 in group II (p
      PubDate: Sat, 29 Oct 2022 00:00:00 +030
  • Why do we do EEG' Experience of two years from a new pediatric
           neurology center

    • Authors: Emine TEKİN; Betül DİLER
      Abstract: Electroencephalography (EEG) is very important for pediatric neurologists. The request reasons and results of EEGs from a newly established center were enrolled. Total of 2021 (1299 sleep + awake, 652 sleep, 70 awake) EEGs evaluated. Patients included 1005 girls and 1016 boys. 65% of the EEGs were normal and 30% was epileptic. Electroencephalography was performed due to epilepsy, fainting, first afebrile seizure, febrile seizure, speech retardation, dizziness, headache, movement disorders, gaze abnormalities, behavioral disorders, tremor, sleep disorders, tic, autism spectrum disorders, infantile spasm, encephalopathy, vision loss and abdominal pain in decreasing order. Significantly more common EEGs were performed due to tics (p:0,006), autism spectrum disorders (p:0,04) and speech retardation(p:
      PubDate: Sat, 29 Oct 2022 00:00:00 +030
  • An evaluation of IGF-1 and IGFBP-3 levels in patients receiving growth
           hormone therapy and these parameters therapeutic efficacy

    • Authors: Abdulvahit AŞIK; Semih BOLU
      Abstract: Serum insulin-like growth factor-1 (IGF-1) and insulin-like growth factor-binding protein-3 (IGFBP-3) levels in healthy children reflect endogenous growth hormone (GH) levels, and their daily variations are very low. This study investigated the relationship between growth response and serum IGF-1 and IGFBP-3 levels before and on the first year of treatment in children with GH deficiency (GHD) started on GH therapy. The records of 44 patients diagnosed with GHD, under follow-up at the Adıyaman Education and Research Hospital Pediatric Endocrinology Clinic, and receiving GH therapy for at least one year were examined retrospectively. Patients’ ages, pubertal development stages, peak GH-responses to GH stimulation tests and height standard deviation scores (SDS) measured before and at the first year of treatment, and IGF-1 and IGFBP-3 levels were recorded. Girls represented 27 (61.4%) of the cases in the study and boys 17 (3.6%), with ages ranging between 0.5 and 16.6 years (mean=11.5±3.3). Partial GHD was present in 33 patients (75%) and complete GHD in 11 (25%). Basal height SDS, IGF-1 and IGFBP-3 values were compared with those after one year of treatment. Patients with basal IGF-1 levels < -2 SDS exhibited significantly higher growth responses (p < .05). All three parameters’ mean values were significantly higher after one year compared to baseline. Δ IGF-1 and Δ IGFBP-3 values investigated in the fırst year of treatment together with basal IGF-1 levels can be a useful diagnostic tool in showing growth response in children with GHD started on GH therapy.
      PubDate: Sat, 29 Oct 2022 00:00:00 +030
  • Evaluation of Patients Undergoing Colpocleisis: A Single-Center Experience

    • Authors: Selim GÜLÜCÜ; Neşet GÜMÜŞBURUN
      Abstract: The aim was to evaluate patients who underwent colpoclesis due to pelvic organ prolapse (POP). This cross-sectional study included patients who had undergone colpoclesis surgery. Age, gravity, parity, systemic diseases, examination findings, anesthetic methods used, surgical complications, additional operations, and length of hospital stay were recorded. At evaluation, patients were divided into two groups: partial colpoclesis and total colpoclesis. The mean age of patients was 73.25±5.45 (60-80), gravidity was 4.58±2.38 (2-11), and parity was 4.08±1.45 (2-7). While uterine prolapse was observed in 47 (97.9%) patients, one patient was found to have vaginal cuff prolapse. Partial colpoclesia was performed in 28 (58.3%) of the patients. While 16 of the patients (33.3%) had no additional systemic disease, the remaining patients had at least one systemic disease, with hypertension being the most common at 58.3%. Twenty-eight of the patients (58.3%) underwent surgery under general anesthesia and the rest under spinal anesthesia. While no postoperative complication occurred in 46 (95.8%) of the patients, blood transfusion (erythrocyte suspension) was observed in one patient and delirium was observed in another patient after surgery. The postoperative discharge time of patients was 3.66±2.10 (2-9) days. Statistically significant differences were found between the partial and total colpoclesis groups in terms of age, gravity and parity (p=0.002, p=0.022, and p=0.030, respectively). There were no significant differences between groups in discharge time (p = 0.143) and type of anesthesia (p=0.104). Colpoclesis surgery can be safely performed in elderly patients diagnosed with pelvic organ prolapse who are not sexually active. This method should be recommended as an option, especially in patients with complicated systemic diseases. Although short-term serious complications are not uncommon in patients, routine follow-up of patients with partial colpoclesis for long-term complications should be continued.
      PubDate: Sat, 29 Oct 2022 00:00:00 +030
  • Understanding physicians’ moral distress in the Covid 19 pandemic

    • Authors: Selin KESKİN KIZILTEPE; Asli KURTGÖZ
      Abstract: Moral distress is a significant problem for health care professionals, resulting in reduced job satisfaction, burnout and job retirement This study aims to explore the experiences of emergency physicians related to moral distress during the Covid 19 pandemic. We conducted in-depth semi-structured interviews of 25 physicians working in the emergency department to describe their experiences related to moral distress. Data were analyzed using thematic analysis through the six-step process. Three major themes were identified: (I) The impact of the Covid-19 pandemic on moral distress; (II) The effect of moral distress on physicians; (III) Suggestions to prevent/reduce moral distress. In the light of the results of our study, the moral distress experienced by physicians has been exacerbated due to the increase in the factors causing moral distress to be during the pandemic period as well.
      PubDate: Sat, 29 Oct 2022 00:00:00 +030
           SEA REGION

    • Authors: Nida KIYICI; Recep SANCAK, Gonca HANCIOĞLU, Şefika İlknur KÖKÇÜ KARADAĞ
      Abstract: Background: In the present study, the prevalence of allergic diseases among occupational diseases in hairdressers was examined in Samsun Province, which is located in the Black Sea Region. The purpose was to determine whether hairdresser employees use adequate protective equipment, and to increase the training levels of hairdressers in this respect.Materials and Methods: The Study Group consisted of hairdressers working in the Black Sea Region. A total of 700 hairdressers were included in the study. The data were prepared to determine working conditions, occupational and environmental allergic diseases. The ISAAC Questionnaire Form was modified according to our Study Group. The data obtained were analyzed in computer medium by using the IBM SPSS V23 Package Program. The Mann Whitney U and McNemar Tests were used in the evaluation of the data.Results: It was determined that 310 of the hairdressers who participated in the study worked in female hairdressers, and 390 worked in male hairdressers. It was determined that 97.4% of the female hairdressers who worked in female hairdressers and who participated in the study used protective equipment, 33.5% of them had respiratory complaints before professional life, 9.4% had itching on the skin; 54.5% of them had respiratory complaints after their professional life, and 28.4% had skin itching. A total of 44.2% had an allergic reaction to hair dye, and 42.9% to decolorizer. A total of 25.5% of had obstruction, and 24.2% had cough as allergic reactions. It was determined that 31.6% of those who did not have respiratory complaints before professional life had respiratory complaints after their professional lives. In male hairdressers who participated in the study, it was determined that 63.8% of them used protective equipment, 11.3% had respiratory complaints before professional life, and 31.0% had respiratory complaints after professional life. It was also determined that 30.0% had allergic reactions to hair spray, and 26.2% had allergic reaction to perfume. It was determined that 23.3% had allergic reactions as sneezing and 20.5% obstruction.Conclusion: In the present study, the relation between the allergic diseases of hairdressers and their professions was examined. It was determined that the hairdressing profession increases allergic diseases.
      PubDate: Sat, 29 Oct 2022 00:00:00 +030
  • Establishment of Biocidal Activity Evaluation Study Protocol in Healthcare
           Facility for Routine Monitoring of Antibacterial Activity of Disinfectants

    • Authors: Mostafa EİSSA
      Abstract: Mitigation of the nosocomial infection risk is of prime importance in any healthcare facility to protect patients as well as the working staff's health. To ensure accomplishing this target, one of the crucial good practices is the establishment of rigorous sanitization and disinfection programs that should be executed as part of GxP activity in hospitals. The cornerstone of this task is the implementation of a biocidal validation protocol to evaluate the commercially available antimicrobial formulae in the market against the microorganisms that could be found in the environment. In the present study, a biochemically identified – at least to the genus level -Gram-negative microorganism was found on three different occasions belonging to the Burkholderia cepacia complex (BCC). The disinfectant validation program was executed using four chemically different antimicrobial formulae that embraced alcohols, amphoteric detergent and peroxygen products. A preliminary neutralization study design evaluation was established before the biocidal assessment to ensure effective stoppage of the antimicrobial activity after a specific contact time with the microorganism using a bacterial count range between 40 and 100 Colony Forming Unit (CFU) which was determined by serial dilution. An acceptable neutralization (in terms of toxicity and efficacy) was achieved through a combination of chemical and dilution methods. Contact surface method for testing the biocides was applied using three different coupons that were made for the material of construction of the covers or lining of the walls, floors and metallic surfaces. Microbial reduction level exceeded 15,800 times the original count of ≥ 1 x 106 CFU/coupon with all groups and replicates at zero- and two-weeks storage time of the prepared and diluted disinfecting solution. The disinfectants that have been challenged in this study showed acceptable activity against the vegetative organism of concern in the healthcare industry with 2-hydroxypropane being slightly the least active among the group.
      PubDate: Sat, 29 Oct 2022 00:00:00 +030
  • Cupping therapy combined with conventional Physical Therapy improves pain

    • Authors: Nida KİANİ; Furqan Ahmed SİDDİQİ, Warda Ajaz QAZİ, Ruqia BEGUM, Shoaib KAYANİ, Arva NAEEM, Sanna PERVAİZ
      Abstract: Background: Cupping therapy is a traditional therapy treatment used since ancient era. It is a therapy of alternate medicine, gaining popularity in physical medicine because of minimal adverse effects, reduction in pain and muscle tenderness. Very little literature is available on the combine effect of cupping therapy and conventional physical therapy in order to treat low back pain in female patients. Aim: To evaluate effects of cupping therapy combined with conventional Physical therapy in order to improve the pain and health related quality of life among female patients with low back pain. Experimental Procedure: Randomized control trial done on diagnosed cases of 40 low back pain female patients in Fauji Foundation Hospital, Rawalpindi. Experimental Group (A) received cupping therapy once every two weeks for 4 weeks combined with conventional physical therapy including hot pack, interferential therapy and strengthening exercises for back done 3 times per week for 4 weeks. Control group (B) did not received cupping therapy, only conventional Physical therapy was given and their outcomes were observed at the baseline and at the end of 4 weeks sessions.Results: Results showed significant improvement in the measured variables of pain and low back disability as well as in physical health, psychological health, and social relations whereas no such significant improvement was seen in environmental health. Conclusion: Combined effect of cupping therapy along with conventional physical therapy helps in reducing not only low back pain symptoms but also improve the health related quality of life among female patients.
      PubDate: Sat, 29 Oct 2022 00:00:00 +030
  • The impact of family history of preeclampsia and alteration of
           MMP-13/TIMP-1 balance in the occurrence of preeclampsia

    • Authors: Asparuh NİKOLOV; Nikola POPOVSKİ, Irena HRİSTOVA
      Abstract: Tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) suppresses the activity of matrix metalloproteinase-13 (MMP-13). The MMP-13/TIMP-1 complex has been proposed to be one of the regulators of collagen types I and III turnover in healthy pregnancy. This study is intended to investigate the distribution of serum levels of MMP-13, TIMP-1 and ratio of MMP-13/TIMP-1 in women with preeclampsia (PE) with a family history of preeclampsia. 37 patients with PE were examined, mean age 24.9±6 years and 32 age matched healthy subjects, mean age 24.7±5.4 years. Patients were divided in two subgroups: subjects with family history of PE (n=18); (PE+FHPE) and subjects without family history of PE (n=19); (PE-FHPE). MMP-13 and TIMP-1 levels were measured via enzyme-linked immunosorbent assay (ELISA), while the ratio was calculated. Either MMP-13 or TIMP-1 alone did not exhibit any obvious differences between normal and PE pregnancies. MMP-13/TIMP-1 ratio was statistically significantly higher in PE than healthy pregnant women: 0.2 (0.1÷0.5) vs. 0.065 (0.05÷0.2) (p
      PubDate: Sat, 29 Oct 2022 00:00:00 +030
  • The Relationship between Demographic Indicators and Mortality Rate of
           Covid-19 Disease Comparatively and Retrospectively in Different Waves of
           Covid-19 Disease in Iran

    • Authors: Kamran AGHAKHANİ; Siamak SOLTANİ, Azadeh MEMARİAN, Shahrokh Mehrpisheh SHAHROKH MEHRPİSHEH
      Abstract: Coronavirus disease-19 (COVID-19) is a novel emerging infectious disease caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). In this study, we aimed to examine the relationship between demographic indicators and mortality rates in Covid-19 disease in different Covid-19 waves in Iran. In this retrospective cross-sectional study, the study population consisted of 9874 patients of Covid-19 admitted to Hazrat Rasoul Akram Hospital of Tehran, from the beginning of the disease to the end of the fifth wave. Demographic variables such as age and sex as well as clinical variables such as hospitalization date and mortality rate were collected and evaluated. The analysis was performed using SPSS software version 26. The mean age of 9874 participants was 58.9 ± 17.0 years. In this study 5510 (55.8%) of patients were male. 1762 (17.8%) patients died. The fifth wave had the highest number of patients (31.1%) and the trend in the number of patients was increasing from wave second to fifth. However, the percentage of death was lower in waves fourth (14.5%) and fifth (15.3%). The mean age of deceased patients was significantly greater than alive patients (69.25 ± 14.60 vs. 56.76 ± 16.75, P=0.0001). The frequency of male deaths was significantly higher than female deaths (P=0.0001). The results of the present study indicate that the frequency of mortality in recent waves, despite a significant increase in hospitalization, has been decreased. It can also be said that mortality increases with age as well as male gender, and males are more prone to death due to covid-19 disease with age.
      PubDate: Sat, 29 Oct 2022 00:00:00 +030
  • Placental Chorioangioma With Dysgenesis Of Corpus Callosum : A Case Report

      Abstract: Chorioangioma is the most common benign tumor of placenta which results from vascular malformations. Their clinical significance changes according to their associated complications such as preeclampsia, premature release of placenta, polyhydramnios, intrauterine growth restriction , fetal anemia, fetal cardiomegaly and fetomaternal hemorrhage . This case is about a 32 years old patient whose pregnancy was complicated by a large placental chorioangioma at 3rd trimester.
      PubDate: Sat, 29 Oct 2022 00:00:00 +030

    • Authors: Fadime KARAMAN ATASEVER; İnci GÜNGÖR
      Abstract: Syphilis is a chronic bacterial infection caused by Treponema pallidum, which is a common endemic in low-income countries while it occurs at lower rates in middle-income and high-income countries. Syphilis is a significiant individual and public health problem given the increased risk of HIV infection and lifelong morbidities in children born to infected mothers (1). Syphilis can be diagnosed at any stage and can affect multiple or a single organ, mimicking many diseases (2) .It is known as the 'great imitator' as it manifests itself in various forms which are often causing misdiagnosis with other conditions (8) . Ocular findings can be seen in all stages of syphilis (7). We have reported a patient of ocular syphilis with a diagnosis of the secondary syphilis stage in this case report.
      PubDate: Sat, 29 Oct 2022 00:00:00 +030
  • Drug repositioning approach to target ‎viral and host cells in the terms
           of COVID-19 treatment: A review of ‎in vivo experiments and clinical

    • Authors: Ali SHAHALİ; Vajihe AKBARİ, Rasool SOLTANİ, Shirinsadat BADRİ, Rashid ALİJANİ ARDESHİR
      Abstract: While the COVID-19 pandemic is expanding at an alarming rate, there is currently no treatment ‎option for this disease. Therefore, it is necessary to find an effective treatment special ‎for hospitalized COVID-19 patients at the earliest possible time. One of the promising options which should be investigated is the possible effects of old drugs or ‎drug repositioning. This strategy has less risk with more economical advantages and can be beneficial for the long-term control of this pandemic. Our study aimed to give an overview, update the current status of drugs candidates (both virus-targeting and host-targeting drugs) for repurposing in COVID-19 infection, and assess the possible mechanism of their effect, in vivo antiviral efficacy, and clinical studies
      PubDate: Sat, 29 Oct 2022 00:00:00 +030
  • The Effects of Maternal Anticoagulant Therapy on Cord Blood Levels of
           VEGF-A and Soluble Flt-1 in Women with Recurrent Miscarriage

    • Authors: Şahin TAKÇI; Ayşe KORKMAZ TOYGAR, Şule YİĞİT, Murat YURDAKÖK
      Abstract: Angiogenic imbalance of the placenta is one of the prominent pathophysiologic mechanisms leading to pregnancy complications like recurrent miscarriage. Low molecular weight heparin and low dose aspirin are frequently used in the management of recurrent miscarriages. Vascular endothelial growth factor (VEGF) and its soluble receptor-sFlt-1-plays a major role in angiogenesis. This study aims to investigate cord blood VEGF-A and sFlt-1 levels of women with recurrent miscarriages who receive anticoagulant treatment. Term newborns whose mothers were treated with LMWH and low-dose aspirin due to recurrent miscarriage were prospectively included. A control group consisted of healthy gestational age-matched infants who were born in the same period without an adverse perinatal outcome. The concentrations of VEGF-A and sFlt 1 in umbilical cord blood were assayed by ELISA and compared between the study and control groups. Forty-four infants with a maternal LMWH and low dose aspirin treatment during pregnancy and 42 healthy infants as a control group were included in the study. There were no significant differences in demographics, cord blood VEGF-A and sFlt-1 levels between the groups. There was also no correlation between the cumulative LMWH dosage and serum levels of these angiogenic factors.Cord blood VEGF-A and sFlt-1 levels were comparable in women with recurrent miscarriage under anticoagulant treatment and healthy subjects. Further studies are needed to compare women who have recurrent miscarriage with or without heparin treatment to better understand the effects of anticoagulant treatment on circulatory profile of cord blood angiogenic factors.
      PubDate: Sat, 29 Oct 2022 00:00:00 +030
  • Is Hashimoto Thyroiditis a Risk Factor in Male Infertility'

    • Authors: Murat ÖNAL; Mehmet AĞAR, Aynur Adeviye ERŞAHİN, Kağan GÜNGÖR
      Abstract: Hashimoto's thyroiditis is known as thyroid dysfunction and is one of the most common endocrine diseases worldwide. This study seeks to investigate thyroid dysfunction in the male reproductive system. Normal thyroid function is crucial for male reproduction. Semen quality parameters are among the most critical factors affecting male fertility. The main aim of this research was to investigate the effect of thyroid dysfunction on semen quality parameters such as sperm motility, number, and morphology. This cross-sectional retrospective case-control study was conducted between December 2021 and May 2022 in Bahcesehir University Göztepe Medicalpark Hospital Invitro Fertilization center. Patients with Hashimoto's thyroiditis (n=52) were included in the study as the case group. The control group was selected from age and body mass index (BMI)-matched patients who underwent semen analysis (n=57). The participants’ age and BMI were 30.90±4.45 and 24.49±1.46, respectively. When we evaluated semen analysis results, we found the number of sperms (p
      PubDate: Sat, 29 Oct 2022 00:00:00 +030
  • Hematopoetic Stem Cell Transplantation in Children

    • Authors: Canan  ALBAYRAK
      Abstract: Bone marrow transplantation is now called hematopoietic stem cell transplantation (HSCT) because, apart from bone marrow, peripheral blood and umbilical cord blood can also be used as stem cell sources. HSCT can be performed in three ways. One is autologous stem cell transplantation. The other is allogeneic stem cell transplantation. Another type of transplantation applied in recent years is haploidentic transplantation. More than 20% of all allogeneic HSCTs are performed in patients under 20 years of age. HSCT has become a well-established lifesaving treatment procedure for many patients with hematological malignancies, hemoglobinopathies, inborn errors, or bone marrow failure syndromes. HSCT is now integrated as an essential part in many treatment concepts and protocols. HSCT is a treatment that provides an increase in success compared to other treatments when it is performed in suitable patients and in accordance with the standards. Selection of the appropriate transplant type, appropriate donor, appropriate preparation regimen, and close monitoring of complications are essential.
      PubDate: Sat, 29 Oct 2022 00:00:00 +030
  • The Role of Inflammatory Markers in the Diagnosis of Extraperitoneal

    • Authors: Selim GÜLÜCÜ; Neşet GÜMÜŞBURUN
      Abstract: ABSTRACTOBJECTİVE: This study was concerned with the examination of patients who underwent surgery for subcutaneous endometriosis in our clinic and the relationship between subcutaneous endometriosis and inflammatory markers.MATERİALS AND METHODS: Patient demographics and information on history and duration of previous surgery, lesion size, number of lesions, location, recurrence, symptoms, type and number of deliveries, recurrence status, and imaging method were recorded. Laboratory analysis recorded TSH, blood count (Hb), WBC, mean platelet volume (MPV), neutrophil/lymphocyte ratio (NLR), monocyte/platelet ratio (MPR), lymphocyte/monocyte ratio (LMR), platelet/lymphocyte ratio (PLR) and CA -125 values of patients.RESULTS: The study included 28 patients and it was found that the mean age of the patients was 32.67±5.56 years. Five (17.9%) and 18 (64.3%) of the patients complained of a palpable mass and cyclic pain, respectively. Five patients (17.9%) were asymptomatic. Endometriosis associated with the scar line was localized in 18 (64.3%) of the patients. In three (10.7%) of the patients, the endometriosis was localized in the perineal line and in 7 (25%) of the patients in the rectus abdominis. No significant difference was found in the patients' routine laboratory results and inflammatory markers. CONCLUSION: In the present study, there was no significant association between the levels of inflammatory markers in patients who underwent surgery for subcutaneous endometriosis at different sites and with different symptoms.
      PubDate: Sat, 29 Oct 2022 00:00:00 +030
  • Development and pilot testing of remote active learning tool as
           antimicrobial stewardship co-interventions

    • Authors: I Wayan SURANADİ; I Gusti Agung Gede Utara HARTAWAN, Antonius Budi SANTOSO, Ni Nengah Dwi FATMAWATİ
      Abstract: Purpose: Online education tool is known for its cost-effectivity as antimicrobial stewardship intervention, yet only a limited number of studies was done in developing country settings. This pilot was therefore conducted to assess the feasibility, acceptability, and effect of the prescriber-directed distance learning model and analyze feedback for future intervention.Patients and methods: The research procedure was outlined in preparation, conduct, and evaluation phase under antimicrobial resistance control committee supervision. The preparatory phase included learning tool planning and finalization to be disseminated in the conduct phase. Educational intervention delivery was preceded and followed with pre- and posttest to assess attendings’ knowledge, attitude, and practice regarding AMS and collect feedbacks on intervention components. Test scores were compared using paired t-test, and feedbacks were analyzed as aggregates as barriers or facilitators of AMS intervention.Results: A total of 203 subjects were included in the analysis with 99% recruitment rate and 96.7% adherence rate. Proportions of subjects with adequate knowledge and attitudinal scores improved from initially 36.9% and 21.2% before intervention into 83.3% and 51.7%, respectively. Mean knowledge score in pretest (6.1±1.2) increased significantly in posttest (7.6±1.1) with p-value less than 0.001. Knowledge on antimicrobial classification and prescription workflow were the main topics with the least number of correct answers. Facilitators identified in the feedback were access to workflow, guideline, resistance pattern, and course, while antimicrobial availability was regarded as a barrier to optimal AMS implementation.Conclusion: The findings suggest the feasibility and acceptability of the evaluated protocol. Protocol modification and expansion of study recruitment hold the potential to improve AMS intervention efficacy.
      PubDate: Sat, 29 Oct 2022 00:00:00 +030
  • Management of Subcutaneous Emphysema Due to Penetrating Oropharyngeal

    • Authors: Emel TAHİR; Emre DEMİREL, Hatice ALBAYRAK, Nazik  AŞILIOĞLU, Sinan ATMACA
      Abstract: Background: Penetrating trauma to the oropharynx is a rare problem in children. Although the majority of cases heal with no long-term consequences it can result in fatal complications. In this case report we discuss how a spoon-related oropharyngeal trauma case was treated. Case: A 7-year-old child fell facedown while eating ice cream, the spoon became inserted in his. A vertical 3-4 cm laceration in the midline of the posterior wall of the pharynx was discovered. There was subcutaneous and retropharyngeal air values extending into the upper mediastinum in his computed tomography scan. While the patient was intubated and monitored in the pediatric intensive care unit. Broad-spectrum antibiotics were initiated to prevent infectious complications. As his subcutaneous emphysema regressed, he was successfully extubated.Conclusion: In penetrating trauma of the oropharynx; to avoid fatal complications, early commencement of antibiotic therapy, and close monitoring of the in the intensive care unit is vital.
      PubDate: Sat, 29 Oct 2022 00:00:00 +030
  • Investigation of Pediatric Innocent Murmur with Echocardiography

    • Authors: Naile TUFAN PEKKÜÇÜKŞEN; Tuğba TAŞ, Sadi TÜRKAY
      Abstract: AbstractIntroduction: Innocent murmurs are common in childhood. Usually, they are heard without any structural and physiological abnormalities. The murmur is usually weak and short. But even if it is thought to be innocent, echocardiography (ECHO) is occasionally requested by primary doctor or families. The aim of this study is evaluation of childhood innocent murmur with ECHO and possible minor findings with normal clinical status. Method: This is a descriptive - retrospective chart review. We reviewed the charts of children and adolescents who were referred with asymptomatic murmur to Pediatric cardiology clinic at Fatih University Hospital between 01/ 2010 – 12/2011. We excluded cases who are found with any type of congenital/acquired cardiac diseases. Due to the nature of this study, we only included first to third degrees of murmurs. All participants are analyzed based on demographic, clinical, and ECHO finding data. Results: We reviewed 610 charts. 115 cases (18%) were excluded. 495 cases (82%) were included in the study. 209 (42.2%) of them were female and 286 (57.7%) were male. Age range was between 1 and 202 months (52,2 ± 41,9), height was between 50 and 175cm (102,2 ± 28,8) and body weight was between 3.70 and 97kgs (18,8 ± 12,89). Minimal Tricuspid valve regurgitation (TVR) was seen in 200 children (40.4%) and minimal TVR+ physiological Mitral valve regurgitation (MVR) was seen in 65 children (11.6%). Patent foramen ovale (PFO) was seen in 306 children (54,8%). Left ventricular (LV) muscular band (false tendon) was seen in 171 children (30,6%). Minimal TVR + physiological MVR+ LV muscular band (false tendon) was seen in 26 children (4,7%), trivial arteria valve regurgitation (AVR) was seen in 7 children (1,4%), and minimal TVR + minimal pulmonary regurgitation (PR) was seen in 11 cases (2%).Discussion: Even though the nature of murmur in physical exam supports the diagnosis of innocent murmur, evaluation with ECHO is commonly requested by families and physicians. In our study we excluded 18% of cases due to the presence of primary cardiac diseases. Included cases also exhibited some cardiac findings but none of those cause any shown cardiac dysfunction in near future. We advise innocent murmur group to be followed by primary physician unless they have any cardiac symptoms.
      PubDate: Sat, 29 Oct 2022 00:00:00 +030
  • Knowledge and Perceptions of the Use of Complementary and Alternative
           Medicine in Dental Clinic Students in Makassar, Indonesia

    • Authors: Ayub ANWAR
      Abstract: To find out the knowledge and perspectives of professional students of the Faculty of Dentistry of Hasanuddin University regarding complementary and alternative medicine in the field of dentistry. The clinical students of class 2014 and 2015 are the respondents in this study. Each received an online questionnaire in the form of Google Form, which consists of questions about knowledge and perspectives on complementary and alternative medicine, along with additional questions about the characteristics of the respondents (gender, class). The data are then analyzed with statistical analysis. The mean correct answers to five items of the clinical question from 148 participating students were 2.22 ± 1.14. Of the 740 correct answers expected (5 correct answers from each student) for 5 clinical questions, only 329 correct answers (44.45%) were obtained. The percentage of students who have little to no knowledge about CAM is 85.8% (127 students). Only 29 students (19.6%) disagreed that CAM was necessary for health and dental services. Twenty-one out of one hundred forty-eight students stated that they knew CAM. More than half of the students are interested in learning more about CAM and agree that CAM education should be integrated into the curriculum.
      PubDate: Sat, 29 Oct 2022 00:00:00 +030
  • Evaluation of Sleep Quality and Physical Activity Levels of University
           Students During the COVID-19 Pandemic

    • Authors: Ramazan GÜNEŞER; Aydın HİM
      Abstract: The aim of our study was to investigate the sleep quality and physical activity levels of university students during the COVID-19 pandemic. The study was conducted on 128 volunteer students who were studying at Bolu Abant Izzet Baysal University, Vocational School of Health. The data was collected online through the socio-demographic data form, the Pittsburgh Sleep Quality Index (PSQI), and the International Physical Activity Questionnaires (IPAQ). The average PSQI score of the students was 8.87±3.47 with 81.3% of the students having poor sleep quality and 18.8% of the students having good sleep quality. The total physical activity score was 1259.73±2183.33 (MET-Min/week). The percentage of students who had no vigorous physical activity was 80.5% and while 59.4% did not do moderate physical activity, and 5.5% did not have adequate walking activity. About 53.1% of the students were not physically active, 32% had low physical activity, and only 14.8% had adequate physical activity. COVID-19 pandemic has had several adverse effects on students' sleep quality and physical activity levels. During the pandemic, we think that students had difficulty forming regular biological rhythms, especially sleep and physical activity, due to various reasons such as concerns about education, quarantine and social isolation. In order to reduce the negative effects of the disease by keeping the immune system strong, necessary information and guidance should be made about quality sleep and adequate physical activity.
      PubDate: Sat, 29 Oct 2022 00:00:00 +030

    • Authors: Aslıhan AKBULUT; Kaan ORHAN
      Abstract: COVID-19 is a pandemic that threatens public health worldwide. Dentists working at great risk play an important role in protecting public health against the coronavirus. The aim of this study was to evaluate the dental patients’ knowledge, attitudes, behaviors, and fear for COVID-19. A self-report questionnaire-based survey was conducted from 10.26.2020 to 01.12.2021. 1110 dental patients were recruited to the survey who applied to the Department of Dentomaxillofacial Radiology of XXXX University Dental School. The survey was divided into 4 divisions: the first part patient’s knowledge about COVID-19, the second division attitudes, the third division the patient’s behavior, fourth part patient’s fear for COVID-19. Cronbach's alpha coefficient was calculated for the reliability of the COVID-19 Fear scale. Significance was evaluated at the p
      PubDate: Sat, 29 Oct 2022 00:00:00 +030
  • Early Predictors of Return of Spontaneous Circulation in Patients
           Undergoing Cardiopulmonary Resuscitation

    • Authors: Ercan NALBANT; Mehmet ALTUNTAŞ, Ali ÇELİK, Özcan YAVAŞİ, Gökhan ERSUNAN, Özlem BİLİR, Gürkan ALTUNTAŞ
      Abstract: Introduction Decisions about when to start, how long to continue and how to end cardiopulmonary resuscitation (CPR) are important in the management of these critically ill patients. The aim of our study is to determine the factors that can help in the early prediction of patients in whom spontaneous circulation can be restored during CPR. Methods Patients who had arrest due to non-traumatic causes were included in the study. The patients whose spontaneous circulation (ROSC) was restored in the emergency service and who were hospitalized in intensive care were included in ROSC (+) group, while the patients who did not have ROSC and who became exitus were included in ROSC (-) group. Patients’ demographic characteristics, chronic diseases, places of arrest, admission laboratory values and possible causes of death were compared between ROSC groups.Results This study was conducted with the retrospective examination of 309, 118 (38.2%) female and 191 (61.8%) male, cardiopulmonary arrest cases. ROSC was achieved in 94 (30.4%) of the patients who underwent CPR. It was found that a 0,1 unit increase in pH value increased the probability of ROSC by 38% [OR: 1,38 (95% CI: 1,22-1,55), p
      PubDate: Sat, 29 Oct 2022 00:00:00 +030
  • The effects of methanolic plant extract on the cardiovascular system of
           induced preeclampticWistar rats

    • Authors: Kenneth ATOE; Macdonald IDU
      Abstract: This work investigated the effects of methanolic plant extract on the cardiovascular system of induced preeclamptic Wistar rats. Preeclampsia is associated with increase in high blood pressure and proteinuria. Studies have shown the only medically acceptable treatment is the removal of the fetus from the mother, however there is considerable lack of studies done to show the use of herbal medicine in the treatment and management of preeclampsia. This study reveals the use of plant extract and its effect on cardiovascular system. Three plants extract; Jatropha curcas, Alchornea cordifolia andSecamone afzelii were used for the study. Results showed that there were no observable lesion or abnormally in the cardiovascular system and the use of all three plant extracts significantly reduced blood pressure and proteinuria, thus indicating a reduction of preeclampsia from severe to mild.
      PubDate: Sat, 29 Oct 2022 00:00:00 +030
  • Investigation, design and synthesis of new anticancer agents with
           anticancer effect potential on MCF-7 Breast Cancer Cells by Machine
           Learning Method

    • Authors: Suat Utku KESKİN; Muhammet Volkan BÜLBÜL, Semiha Mervenur KALENDER, Sümeyye ÖZYAMAN, Arif MERMER
      Abstract: Cancer is one of the diseases with a high mortality rate, which occurs when cells multiply uncontrollably, acquire an invasive character and metastasize. Breast cancer is one of the cancer types with an increasing incidence worldwide. Chemotherapy is a method used in the treatment of cancer diseases, and the chemotherapeutic drugs used inhibit the growth and proliferation of cancer cells due to their cytotoxic properties. Today, machine learning techniques offer significant advantages by helping several steps of the drug discovery process, reducing the time spent in the laboratory, the use of consumables and chemical materials, and the maximum time predicted for the discovery of a drug with traditional methods. In our study, it was aimed to determine the 3 Schiff base derivatives with the most active cytotoxic effect on breast cancer cells from the large data set using machine learning. In our study, 7 Schiff base derivatives were determined from a large data set containing 98 compounds, and the 3 most active compounds with cytotoxic properties on breast cancer cells and their IC50 values were determined by machine learning method. In the future, it is thought that compound 1 can be used as an alternative to pharmacological applications to be used in preclinical studies as a therapeutic agent, supported by in vitro and in vivo applications, in order to be used in cancer treatments.
      PubDate: Sat, 29 Oct 2022 00:00:00 +030
  • The Relationship between Human Papillomavirus and Anxiety, Depression, and
           Sexual Dysfunction in Women

    • Authors: Naziye GÜRKAN; Tuğba GÜRBÜZ
      Abstract: We aimed to investigate the impact of Human Papillomavirus (HPV) positivity on women’s mental health and sexual dysfunction (SD). Anxiety, hopelessness, and depression were investigated in this study as common psychological problems. This prospective cross-sectional case-control study was done on 213 participants who attended gynecology clinic from February 2021 to May 2022. The Turkish version of Female Sexual Function Index (FSFI)-6 was used to measure SD in women. The Turkish version of Beck Depression Inventory (BDI), Beck Anxiety Inventory (BAI), and Beck Hopelessness Scale (BHS) was used to measure depression, anxiety and hopelessness in women. According to the HPV test results, the subjects were divided into two groups: 1st group as HPV positive and 2nd group as HPV negative. 97 women in the 1st group and 116 patients in the 2nd group were included in the study. The participants’ age and body mass index (BMI) were 33.91±3.74 and 24.88±3.01, respectively. There was a significant difference between the women with HPV-positive and HPV-negative in FSFI total scores and all subdomains (p-value
      PubDate: Sat, 29 Oct 2022 00:00:00 +030
  • Cerebral Palsy and Oral Health

    • Authors: Manolya İLHANLI; İlker İLHANLI, Peruze ÇELENK
      Abstract: Cerebral Palsy (CP) is a disease characterized by posture, motor and movement disorders, which are caused by non -progressive but permanent damage of the fetal or infant brain in the early stages of life. In addition to these disorders abnormal motion patterns, spasticity and weakness, vision and hearing problems, epilepsy, cognitive function disorders may be accompanied. Neuromuscular problems due to CP adversely affect oral health. In addition to orofacial problems, the influence of the extremities prevents the independence of the individual affected in many areas from oral hygiene to nutritional failures. Sialorrhea, dental caries, periodontal disease, bruxism, malocclusion, dental erosion, traumatic dental injuries, enamel defects, temporomandibular joint disorders and delay in dental eruption are frequently experienced in patients with CP. The aim of this study was to examine the publications related to oral health in CP patients in the literature and to compile oral health problems and methods of managing these problems in patients with CP. 'Cerebral Palsy, Oral Health, Oral, Dental, Health, Care, Hygiene, Caries, Dysphagia, Malocclusion, Bruxism, Tooth Brushing ’and combinations of these words are scanned in Turkish and English in health databases (PubMed, Cochrane, Embase, Medline and others). Studies containing at least one subject for oral health in CP patients have been included in the examination. Existing approaches and standards were investigated. The populations examined in the studies are considered to be any subtypes of the CP, to be included in our study. The references of all scanned articles were also sought and examined. As a result, CP, one of the diseases with special requirements, brings many oral health problems. These problems adversely affect the quality of life as well as the general health of the affected individual. It is important that health professionals especially dentists, patients, patients’ parents and caregivers should be aware of the oral health problems that may be encountered, should have information about protective and therapeutic methods and determine the risks and be encouraged to configure the correct treatment protocols.
      PubDate: Sat, 29 Oct 2022 00:00:00 +030
  • Evaluation of demographic characteristics and laboratory results of
           patients with Covid-19 treated in the intensive care unit

    • Authors: Nevin AYDIN; Osman ESEN, Umut KARAYALÇIN
      Abstract: Background: We aimed to investigate the clinical features, hemodynamic and respiratory profiles as well as prognostic outcomes of critically sick COVID-19 patients admitted to intensive care units (ICUs).Methods: This retrospective study was performed using data derived from 99 adult patients treated in the ICU. Demographic and clinical data as well as hemodynamic and respiratory profiles, theraputic outcomes were recorded. The relationship between these features and ICU stay was sought. Results: The average age was 65.94 ± 14.93 years (24 to 96), and 73 patients (73.7%) had comorbidities. Smokers constituted 13.1% of the Covid-19 patient population (n=13) in ICU. Thirty-one cases (31.3%) had received at least one dose of Covid-19 vaccine and 63 patients (63.6%) died in the ICU after their initial hospitalization. Blood products were utilized in 29 patients (29.3%) and delta mutation was detected in 23 (23.2%) of ICU patients. The mean duration of ICU stay was 16.90 ± 11.41 days (1 to 60). The duration of ICU stay was remarkably different between groups receiving different antibiotic regimens (p
      PubDate: Sat, 29 Oct 2022 00:00:00 +030
  • The Effects of Sperm Parameters and Sperm DNA Damage on pregnancy outcomes
           of women undergoing intrauterine insemination

    • Authors: Murat ÖNAL; Müstecep KAVRUT, Nur DOKUZEYLÜL GÜNGÖR, Tuğba GÜRBÜZ
      Abstract: In this study, we compared the effects of sperm parameters and sperm DNA damage on pregnancy outcomes of women undergoing intrauterine insemination (IUI) because of an ovulatory dysfunction (OD) and unexplained infertility (UEI). This study was retrospective, and semen samples were collected from records of 88 infertile couples referred to private clinic for infertility treatment from December 2019 to March 2020. The study has two groups: Groups 1: couples with UEI, and Group 2: fertile males with their partners having OD. The participants' age and body mass index (BMI) were 28.20 ± 3.08 and 25.45±2.25, respectively. In the control group,the pregnancy rate was 9/41 (%21.9), and one out of nine patients had a miscarriage. The pregnancy rate in the study group (UEI) was 8/47 (17%), and half of the pregnancies ended as miscarriage. Our results showed that sperm DNA damage increases the abortion rate but has not influenced the pregnancy rate in IUI.
      PubDate: Sat, 29 Oct 2022 00:00:00 +030
  • Does the Frequency of Ureaplasma Increase In Human Papillomavirus Positive

    • Authors: Asena AYAR MADENLİ
      Abstract: This study aimed to investigate the positive prevalence rate of Ureaplasma in Human papillomavirus (HPV) positive women. The role of sexually transmitted diseases (STD) in developing cervical cancer is evident. Clinical consequences can be prevented by screening and identifying risk factors. This retrospective cohort study was approved by the Ethics Committee of Sisli Memorial Hospital. Ureaplasma and HPV and PAP smear tests were performed for 526 sexually active women aged between 21 and 45 years (mean 31.66±4.91 years) visiting a Sisli Memorial Hospital for routine cervical screening. The association of HPV and Ureaplasma detection with cytological results were examined. The prevalence of Ureaplasma in asymptomatic women was 31%, high-risk HPV (HR-HPV) and Ureaplasma coincidence as 56.6% and the prevalence of Ureaplasma in HR-HPV was 91.5%. Most positive HPV was observed in the age range of 26-30 (50%). The most positive Ureaplasma was observed in the age range of 26-30 (51%). The highest simultaneous occurrence of two infections was observed in the age range of 26-30 (51%). Cervical screening abnormality was observed more in Ureaplasma-positive women. There was a statistically significant association between pap smear result and Ureaplasma (p-value < 0.001). There was a statistically significant association between HPV-positive and Ureaplasma (p-value < 0.001). There was a statistically significant association between HR-HPV and Ureaplasma (p-value < 0.001). Regarding the high prevalence of Ureaplasma in HR-HPV women, screening in women, especially in the age range of 26-30 years, is a breakthrough and can prevent adverse clinical consequences.
      PubDate: Sat, 29 Oct 2022 00:00:00 +030
  • Effect of lead exposure during perinatal period on kidney of adult
           offspring in rat: A stereological study

      Abstract: Lead is the most common toxic metal in nature, and its adverse effects on various organs, including the kidneys. Kidney development is a complex process that is influenced by various environmental factors. Although lead toxicity can occur at any age, it is important in pregnant mothers and infants. Therefore, in this study, the effects of low dose lead administration on kidney offspring in rat model were investigated using stereology technique.The animals were randomly divided into in to five groups. Group 1 (control) animals had access to normal drinking water plus 0.5 ml/liter of glacial acetic acid (as a lead acetate solvent) through the study. Group 2 animals were administrated 0.2% of lead acetate in drinking water for 30 days before mating. Group 3 rats received drinking water with 0.2% of lead for 21 days during pregnancy. Group 4 animals received 0.2% of lead acetate in drinking water for 21 days during lactation. Group 5 animals were given 0.2 % lead acetate in drinking water during pre-pregnancy (30 days), pregnancy (21 days) and lactation (21 days) periods. The left kidney was removed from male offspring 60 days after birth. The volume of the kidney, cortex, medulla, proximal convoluted tubules (PCT) and distal convoluted tubules (DCT), as well as the length of PCT and DCT, were analyzed by means of stereology.Results showed a decrease in the volume and length of the DCT and also some pathological effects in experimental groups, in comparison with the control group. Due to the ameliorating effect of lead in perinatal period even in low doses on offspring kidneys, cautiousness is needed in this period.
      PubDate: Sat, 29 Oct 2022 00:00:00 +030
  • Effects Of Cholecystectomy On Pipid Profile

    • Authors: Altan AYDIN; Doğan ÖZTÜRK
      Abstract: Introduction: Cholecystectomy is widely used to treat gallstone disease as one of the surgical procedures which have been most frequently performed worldwide. The bile acids pool has unchanged size, but it has fast circulation, which causes to expose the enterohepatic organs to increased flux of bile acids per day in cholecystectomized patients. This study aims to evaluate blood lipid levels before and after cholecystectomy.Methods: The total number of 80 consecutive patients underwent elective cholecystectomy were included in this study. Lipid parameters, biochemical analysis were obtained before surgery and after 12 weeks of cholecystectomy. Results: Mean age was 49±13. Sixty (75%) patients were female. None of the subjects died during perioperative course. Levels of total cholesterol (191.9 ±37.1 mg/dl vs. 186.1 ±36.8 mg/dl, respectively; p=0.006), LDL-C (142.6±41.7 mg/dl vs. 133.9±35.1 mg/dl, respectively; p
      PubDate: Sat, 29 Oct 2022 00:00:00 +030
  • Comparison of the Effects of Acupressure and Ice massage in Primary
           Dysmenorrhea: A Randomized Controlled Trial

    • Authors: Naimeh POURRAMEZANİ; Maryam FİROUZABADİ, Fatemeh ALAVİ, Mohadeseh BALVARDİ, Moazameh Sadat RAZAVİ NASAB
      Abstract: The aim of the study was to compare the effectiveness of acupressure and ice massage treatment methods in the treatment of primary dysmenorrhea. The 210 female students were randomly divided into three groups of acupressure, ice massage and control group. In the acupressure group, pressure was performed at the Hugo point through applying a medium pressure for 10 minutes' massage. The procedure was repeated for 5 times. In the ice massage group, 2 cm diameter circular ice pieces were used. Massage with ice was carried out rotationally for 10 minutes. Like the acupressure, the procedure was repeated for 5 times. In the control group, glass marbles were applied at the Hugo point with no pressure and massage for 10 minutes. The intensity of pain was measured prior to the intervention, during the intervention and following the intervention using visual analogue scale. At the beginning, the mean VAS scores were 7.41 ± 1.82, 6.74 ± 2.23, and 7.03 ± 1.72 in the participants in groups control, acupressure and ice massage, respectively (P = 0.13). After the intervention, the mean pain scores were significantly lower at all of the time points in groups acupressure and ice massage than in group control participants (P < 0.001). Although the pain scores showed a more decreasing trend after the intervention in group ice massage than that in group acupressure, the difference between the two groups was not statistically significant (P = 0.97). It was revealed that treatment with acupressure and ice massage can also be recommended as a complementary medicine treatment for the treatment of primary dysmenorrhea with no reported side effects.
      PubDate: Sat, 29 Oct 2022 00:00:00 +030
  • Plasma netrin-1 levels in Familial Mediterranean fever: a potential

    • Authors: Ebru ATALAR; Kevser GÖK, Esra FIRAT OĞUZ, Ahmet KOR, Yüksel MARAŞ
      Abstract: Netrins are primarily defined as being of guidance in axonal cell migration in the embryonic period. Cell migration has an important role in the occurrence of organogenesis and inflammation. In the etiopathogenesis of autoimmune diseases, there is said to be tissue destruction associated with uncontrolled activation of the immune system and uncontrolled migration of inflammatory cells to tissues. We aimed to determine whether netrin-1 has a role in the etiopathogenesis of the FMF disease. This study included 42 patients with Familial Mediterranean Fever (FMF) and 44 healthy control subjects. The plasma netrin 1 levels were measured, and relationships were examined between the netrin levels and demographic data, clinical findings and laboratory test results in both groups. No significant difference was determined between the groups in respect of the plasma netrin levels. The lack of difference between the two groups in this study in respect of plasma netrin levels could suggest that netrin-1 does not have an important role in the etiopathogenesis of FMF. There is a need for further in vivo and in vitro studies to examine netrin-1 and receptors in inflammation tissue samples and in normal tissue.
      PubDate: Sat, 29 Oct 2022 00:00:00 +030
  • Effect of Preemptive Ibuprofen and Dexketoprofen on Postoperative Pain
           After Septorhinoplasty

    • Authors: Özgür KEMAL; Ayşe ÇEÇEN, Esra KAVAZ, Mustafa TAŞTAN, Yavuz ÇEÇEN, Ersin KÖKSAL
      Abstract: Objective: Postoperative comfort is as significant as the postoperative results in patients who underwent septorhinoplasty. Intravenous NSAIDs are playing an increasingly large role in analgesia, antiinflammation and antipyresis in the hospitalized setting. The aim of this study is to assess the preemptive analgesic effect of intravenous ibuprofen and dexketoprofen on postoperative pain in patients undergoing septorhinoplasty.Methods: This study was performed with 76 patients who undergoing open septorhinoplasty between 2016 and 2017. The patients were separated into two groups; Group D (n=46) received preemptive intravenous dexketoprofen (50 mg), and Group I (n=30) received preemptive intravenous ibuprofen (800 mg). Pain was assessed at 30th min and 1st, 2nd, 6th,12th and 24th hrs postoperatively using a visual analogue scale (VAS). There was no statistically significant difference between the groups for sex, age, weight, height, ASA class, anesthesia and surgery duration.Results: VAS scores gradually decreased between 30 minutes and 24 hours in both groups and this decrease was statistically significant in both groups (Group D; p
      PubDate: Sat, 29 Oct 2022 00:00:00 +030
  • Sex-Related Differences in Anxiety in Experimental Functional Dyspepsia
           Induced by Chronic Stress

    • Authors: Osman SİNEN
      Abstract: Functional dyspepsia (FD) is associated with gastric sensorimotor dysfunction (including delayed gastric emptying (GE)) and psychosocial comorbidities. Anxiety is among the many psychiatric disorders that are related to FD. The aim of this study was to compare the effectiveness of chronic sequential stress to create an experimental FD model in male and female rats. The FD model was established by neonatal maternal separation (MS) early in life and repeated homotypic stress (RHS) in adulthood. Newborn pups from postnatal day 1 to day-21 underwent MS for 3 h. In adulthood, the control or maternally separated rats were loaded with RHS for 7 days comprised of 90-min restraint stress. The anxiety-like behaviors were evaluated by the open field (OF) and elevated plus maze (EPM) tests. To validate the experimental FD model, body weight and solid GE were measured in rats after the behavioral experiments. Compared with control males, body weight and GE were significantly (p
      PubDate: Sat, 29 Oct 2022 00:00:00 +030
  • Perioperative Anesthesia Management in a Patient with Eagle Syndrome

    • Authors: Ozgenur BACAKSIZ; Elif ŞENER
      Abstract: Eagle syndrome; prolonged styloid syndrome is a clinical picture caused by an elongated, enlarged and angulated styloid process. Most of the cases are asymptomatic. Symptomatic cases are presented as continuous intermittent pain in the face and anterolateral neck region, which can vary depending on position, reflection pain may be seen in the ipsilateral ear and temporomandibular joint. Patients with bilateral prolonged styloid process may present unilateral complaints. Symptom can manifest itself with foreign body sensation in the throat, episodes of dysphagia and syncope. Syncope episodes are one of the most serious clinical manifestations of the syndrome and are called 'Carotid-Styloid Syndrome'.Patient anamnesis and physical examination are the most importat steps for diagnosis. Palpation of the styloid process in the tonsillar fossa is a clue for Eagle syndrome.Diagnosis should be confirmed by imaginary examinations. Local anesthetic injection into the tonsillar fossa can be used for differential diagnosis. Post-injection pain relief is a symptom in favor of Eagle syndrome. Medical or surgical methods can be used in the treatment of Eagle syndrome.In this article, perioperative anesthesia management of a 38-year-old woman with Eagle syndrome, who was planned to undergo axillary lymph node biopsy in the Ondokuz Mayıs University Hospital, is presented as a case report.
      PubDate: Sat, 29 Oct 2022 00:00:00 +030
  • The comparison of the therapeutic effects of piroxicam gel and oral
           vitamin E in cyclic mastalgia

    • Authors: Razieh BEHZADMEHR; Tahmineh EZAZİ BOJNORDİ
      Abstract: Cyclic mastalgia is a common condition among women. There are different methods in reducing pain in such patients, but there is yet no consensus in this regard. This study aims to compare the therapeutic effects of topical piroxicam gel and oral vitamin E in patients with cyclic mastalgia. Seventy females with mild to moderate cyclic mastalgia were recruited from an outpatient clinic in this randomized, double-blind, placebo-controlled clinical trial. The patients received either topical 0.5% Piroxicam gel four times daily or vitamin E 400IU capsules once daily for two consecutive months. The visual analogue scale (VAS) was used to report pain one and two months later. Thirty-five patients completed the study in each group. Although both medications were effective and safe in reducing pain severity, topical piroxicam led to a significantly better pain control outcome. Almost half the patients required analgesics five months after the study stopped. In conclusion, comparing topical piroxicam gel and oral vitamin E in patients with cyclic mastalgia showed that the former is more efficient in pain control in mid-term. Both medications were safe and well-tolerated.
      PubDate: Sat, 29 Oct 2022 00:00:00 +030
  • Association of Body Mass Index & Android Obesity with Uterine Leiomyoma
           Among Premenopausal Women: A Case–Control Study

    • Authors: Zeynab KARAMİHAMİDABAD; Sara AZİMA, Fatemeh NAJİB, Marzieh AKBARZADEH
      Abstract: Uterine leiomyomas (ULs) or uterine fibroids are the most common genital tumors in women of reproductive age. Obesity and increased visceral fat and the production of inflammatory mediators might be risk factors for ULs. This study aimed to investigate the relationship between ULs and body fat distribution among Iranian women. This case-control study was performed on 280 women of reproductive age with ULs and without myoma in 2020. They referred to three women's clinics in Shiraz (Shahid Faghihi, Zeinabieh, and Motahhari clinics). The sample size for each group consisted of at least 140 subjects selected via consumptive sampling methods. ULs were pre-diagnosed by a gynecologist based on the findings of a vaginal ultrasound. Demographic information, fertility history and history of ULs, body mass index (BMI) and android obesity were recorded and compared in both groups. Chi-square and t-test were used to analyze the data. Most patients with ULs (64 people, 45.7%) aged 41-50 years old. Most of them (126, 90%) were housewives, and the level of education of most patients (74 people, 52.9%) was under high school diploma. The mean of BMI in women with myoma was 26.05±5.32 and in women without myoma was 25.81 ±4.38. There was no significant difference in the mean scores of BMI between the two groups, but the Android fat obesity was higher in patients with ULs. Almost few studies have attempted to identify specific risk factors for this tumor. Preventing weight gain and obesity, and lifestyle modification can prevent Uterine leiomyoma.
      PubDate: Sat, 29 Oct 2022 00:00:00 +030
  • Prognostic Factors Affecting Survival in Breast Cancer Patients Age 40 Or

    • Authors: Can AKGÜN; Bekir KURU, Saim Savaş YÜRÜKER, Ufuk KARABACAK, Necati ÖZEN
      Abstract: Objectives: The aims of this study were to identify the factors affecting survival and disease-free survival (DFS) in invasive breast cancer patients who underwent surgery for breast cancer age 40 or younger.Methods: Medical records of 216 women with breast carcinoma at age 40 or younger who underwent surgery at our Institution between October 2005 and May 2017 were retrospectively reviewed. One hundred and eighty eight invasive breast cancer patients that were eligible were categorized according to their clinical and pathological features. Univariate analyses of survival and DFS were performed by the Kaplan–Meier method and the log-rank test. Independent prognostic and predictive factors affecting survival and DFS were assessed by Cox regression proportional hazard method.Results: 10-year survival and DFS were 85 and 74%, respectively. Axillary involvement, pathologic tumor size, HER 2 + subtype and Triple Negative subtype were found to be the prognostic factors that independently affected survival and DFS.Conclusions: The prognosis is worse in patients with axillary involvement, tumors larger than 2 cm, and HER 2+ and Triple Negative subtypes. These adverse prognostic factors should be considered during treatment and follow-up of patients age 40 or younger.
      PubDate: Sat, 29 Oct 2022 00:00:00 +030
  • Values of Intensive Care Scores in Predicting Morbidity and Mortality in
           Patients Treated for COVID-19 Pneumonia

    • Authors: Hale KEFELİ ÇELİK; Zahide DOĞANAY, Ramazan Burak FERLİ
      Abstract: Some of the patients with COVID-19 pneumonia are followed up in intensive care units (ICU).This study aims to determine the success of intensive care scores used in patients followed up in the ICU with the diagnosis of COVID-19 pneumonia in predicting morbidity and mortality. This retrospective study included patients who were treated with the diagnosis of COVID-19 pneumonia in the ICUs of … Training and Research Hospital. The demographic characteristics, vital signs, arterial blood gas values, radiological imaging, and laboratory data of the patients were used by using the hospital database and patient files. Group I patients were determined as alive patients and Group II as dead patients. A total of 75 patients were included in the study, of which 34 (45.3%) were female and 41 (54.7%) were male.The median length of intensive care stay was 8 (5-15) days in Group I patients and 5 (2-8) days in Group II patients, which was found to be higher in alive patients (p=0.004).Radiological involvement was present in 93.3% (n=70) of the patients included in the study and involvement was seen in both lungs in 77.3% (n=58). Complications were observed in 54.7% (n=41) of the patients included in the study whereas the incidence of complications was 20% in Group I and 72% in Group II, which was statistically significant (p
      PubDate: Sat, 29 Oct 2022 00:00:00 +030
  • Clinical Toxicology of Propranolol and Metoprolol Overdose in Adults

    • Authors: Figen ÖZCAN; Mehmet ALTUNTAŞ, Celal KATI
      Abstract: Beta-adrenergic receptor antagonists potentially risk causing fatal poisoning when taken over the daily recommended doses. The aim of this study is to investigate the differences and potential dose-related effects of propranolol and metoprolol toxicity depending on their selectivity. This 7-year-long retrospective cohort study was conducted among on 43 adult patients who received overdose propranolol (n= 22) and metoprolol (n= 21). Patients were divided into groups, with a daily overdose ≥ 240 mg/day for propranolol, ≥ 200 mg/day for metoprolol, and toxic dose ≥ 400 mg/day for both drugs. The groups were compared in terms of admission symptoms, heart rate, blood pressure, electrocardiography findings, cardiovascular effects, toxicity severity scores, treatment, follow-up times, and outcomes. Thirty-four (79.1%) of the patients who exceeded the daily dose were female, and there were no statistically significant differences between the groups in terms of gender (p= 0,281). The mean age was 29 (18-72) years, and there were no statistically significant differences between groups in terms of mean age (p= 0,192). When the vitals of the patients who exceeded the daily dose was examined, it was found that 23 (54.8%) patients had bradycardia, and 20 (46.5%) patients had hypotension. 65.2% of the bradycardia patients and 70% of the hypotensive patients were in the propranolol overdose group (p= 0,030 p= 0,021, respectively). Mean dose of symptomatic propranolol overdose patients (n= 12) was found as 1256 (280-2000) mg, mean dose of symptomatic metoprolol overdose patients (n= 11) was found as 559 (250-1000) mg. When toxic dose (≥ 400 mg) intakes were compared, more cardiovascular effects were observed in the propranolol group (p= 0,014). As a result, it was determined that Propranolol overdose has more cardiovascular effects than metoprolol overdose and there is a linear dose-symptom relationship for Propranolol.
      PubDate: Sat, 29 Oct 2022 00:00:00 +030
  • Cardiovascular biomarkers in pulmonary hypertension- current applications
           and future directions

    • Authors: Asparuh NİKOLOV; Pavlina GLOGOVSKA
      Abstract: Biomarkers are non-invasive tools, which can be very useful in diagnosis and prognosis of a specific disease. Pulmonary hypertension (PH) is a serious health condition, characterized by increased pulmonary arterial pressure, elevated pulmonary vascular resistance often leading to right heart failure. It may significantly worse patients’ life quality and lead to lethal outcome if not treated properly. Nowadays, there is an increasing interest on PH markers and more specifically how they can contribute in the diagnosis, prognosis and monitoring of the development of this disease. Recent studies on biomarkers in PH suggest several novel and promising molecules, which can be potentially useful in PH work-up and follow-up strategies. This review focuses on biomarkers for diagnosis and prognosis of PH via well-known and some novel cardiovascular disease (CVD) indicators associated with heart failure, myocardial remodelling and injury. Current understandings assume that CVD biomarkers can indicate not only heart abnormalities, but also pulmonary vascular system injury.
      PubDate: Sat, 29 Oct 2022 00:00:00 +030
  • Change in GFR in relation to pulse rate, dipping blood pressure,
           anti-hypertensives, NLR and PLR in patients with chronic kidney disease

    • Authors: Hüseyin DURU
      Abstract: This study aimed to evaluate change in glomerular filtration rate (GFR) in chronic kidney disease (CKD) patients in relation to certain 24-h ambulatory blood pressure monitoring (ABPM) parameters, anti-hypertensives and inflammatory markers. A total of 206 adult CKD patients (mean±SD age: 51.3±17.1 years, 54.9% were females) were included in this retrospective study. Data on patient demographics, comorbidity and medications, 24-h ABPM parameters (pulse rate and dipping systolic and diastolic BP), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR)and GFR were recorded. The change in e-GFR values from baseline was evaluated with respect to study variables. There was a mean -1.5 mL/min/1.73m2(range -80.2 to 18.1) decline from baseline GFR during study period. The decrease in GFR from baseline was significantly lower in patients with vs. without diuretic therapy (median 1.2 vs. 0 mL/min/1.73m2, p=0.017). GFR change from baseline was positively correlated with patient age (r=0.145, p=0.040) as well as with the total (r=0.198, p=0.005), day-time (r=0.184, p=0.009) and night-time (r=0.219, p=0.003) pulse rate. No significant difference was noted in GFR change from baseline with respect to gender, antihypertensive medications other than diuretics, the dipping systolic or diastolic BP values or inflammatory markers. Our findings revealed significant correlation of age, pulse rate and diuretic usage but not dipping systolic or diastolic BP or inflammatory markers with the GFR change from baseline.
      PubDate: Sat, 29 Oct 2022 00:00:00 +030
  • Impact of COVID-19 Pandemic on the Diagnosis of Gastrointestinal Cancer

    • Authors: Tuğba ŞENEL; Talat AYYILDIZ
      Abstract: Coronavirus disease 2019 (COVID-19) pandemic has had a major impact every aspect of life all over the world with severe consequences. Demonstration of its effects in the field of healthcare is very important for countries to make future plans. This study aimed to evaluate the impact of COVID-19 pandemic on the number of gastrointestinal endoscopy procedures and resulting cancer detection rate at our center along with clinicopathological characteristics of the patients by comparing the pandemic period with the same time intervals of previous years. Ultimately, the study intended to better understand how pandemic changed attitudes of patients towards health, how individuals and healthcare centers behaved in response to such an extraordinary situation and whether they avoided seeking medical care. This was a retrospective and single-center study. The 6-month period from March 11 to September 11, 2020 (lockdown period) was compared with the same months of 2018 and 2019 (pre-pandemic period) in terms of the number of endoscopic procedures performed at our gastroenterology unit, malignancy detection rate and clinicopathological characteristics of patients. The data were analyzed using the SPSS Statistics 22.0 software package.A 33% reduction was observed in the number of endoscopic procedures during the pandemic compared to pre-pandemic years and the difference was significant (p
      PubDate: Sat, 29 Oct 2022 00:00:00 +030
  • Does Endoscopic Retrograde Cholangiopancreatography Procedures for Benign
           Pathology Treatment Cause Biliary Reflux'

    • Authors: Amira OTHMAN; Amal DEWEDAR, Hany ELSADEK, Hesham RADWAN, Abeer FİKRY
      Abstract: Bile reflux is caused by the backward flow of duodenal fluid into the stomach. A retrospective cohort study was performed to estimate the prevalence and risk factors of bile reflux gastritis post-ERCP, and its endoscopic and histopathologic consequences on gastric mucosa. The study enclosed 58 patients with refractory epigastric pain and dyspeptic symptoms.They were split into two categories.; the control group (CG): 30 subjects who had never undergone any biliary interventions, and the post-ERCP group (PEG): 28 subjects who have had at least one of the following procedures for benign pathology treatment: endoscopic sphincterotomy (ES) or endoscopic stenting. In CG, the ages ranged from 25 to 68 years with a mean age ± SD of 42.1±12.42. In PEG: the ages ranged from 27 to 59 years with mean age ± SD of 39.25 ± 7.47. All participants had undergone clinical and laboratory assessment and gastroscopy for gastric aspirate analysis as well as gastric mucosa biopsy for histopathological examination. The study showed that the prevalence of bile reflux gastritis was found to be (16.7 %) in CG and (71.43 %) in PEG with a P value of 0.000. In both groups, diabetes, obesity, increased gastric bilirubin, and increased gastric pH were risk factors for bile reflux gastritis (r= 0.28, 0.42, 0.84, 0.66 respectively). However, there were no correlations between age, sex, epigastric pain, heartburn, vomiting, and the occurance of bile reflux gastritis. In Conclusion, bile reflux gastritis is common post-ERCP being more among obese and diabetic patients.
      PubDate: Sat, 29 Oct 2022 00:00:00 +030
  • Analysis of Microscopic Characteristics of Cartilage, Synovial Membrane,
           and Subchondral Bone in Collagenase Induction Model of Knee Osteoarthritis
           Rattus Norvegicus

    • Authors: Caesar Haryo BİMOSENO; Dwikora Novembri UTOMO, Lukas WİDHİYANTO, Aries Rakhmat HİDAYAT
      Abstract: Introduction: Osteoarthritis (OA) is a degenerative arthritis disease of the synovial joints and is one of the most common causes of disability in adults. A study requires experimental animal models to be well understood. Collagenase was found to be able to induce OA in experimental animals. This study was conducted with the aim of analyzing the microscopic characteristics of cartilage tissue, synovial membrane, and subchondral bone in the knee of Rattus norvegicus rats after collagenase injection.Methods: In-vivo experiment using experimental animals Rattus norvegicus which was injected with collagenase was conducted. The sample will be divided into 3 groups: evaluation time at 7 days, 14 days, and 21 days. Synovial and cartilage will be evaluated based on OARSI while subchondral bone will be evaluated based on Subchondral Bone Score (SBS).Result: It was found that cartilage erosion and synovial membrane damage were the most severe in group 3. The level of damage based on OARSI and SBS scoring was also found to be progressive and worsened over time. Subchondral bone values increased in both control and treatment with the control peak at 0.87 and the treatment peak at 3.2.Conclusion: It was found that there was a clear and microscopically progressive difference 3 weeks after collagenase injection. Induction of OA using collagenase injection in experimental animals Rattus norvegicus can be a good model for making secondary OA.
      PubDate: Sat, 29 Oct 2022 00:00:00 +030
  • Use of Monoclonal Antibodies (Bevacizumab, Cetuximab, and Panitumumab) in
           Patients with Metastatic Colorectal Cancer: A Single Center Experience

    • Authors: Gülçin ŞAHİNGÖZ ERDAL; İlkay GÜLTÜRK, Aykut ÖZMEN, Seher Yıldız TACAR, Mesut YILMAZ, Deniz TURAL
      Abstract: Introduction: Despite all the advances in therapeutic modalities, Colorectal Cancer(CRC) continues to be the fourth most common cause of cancer-related deaths. The aim of this study was to share our experiences regarding the usage rates of monoclonal antibodies(mAbs) (such as Bevacizumab, Cetuximab, and Panitumumab), overall survival(OS) and progression-free survival(PFS) in patients with metastaticCRC(mCRC). Material metod: This retrospective study included 210 patients with mCRC who were followed up in our hospital's oncology clinic between January 2010 and October 2020 and who received mAb treatment, regardless of their stage at the time of diagnosis.Results: Fifty-two(24.8%) of the patients received a treatment regimen with Cetuximab and 46 with Panitumumab mAb, 29 patients(17.8%) received Cetuximab and Bevacizumab mAb treatment at different times, and 22 patients received Panitumumab and Bevacizumab mAb treatment, 112 of the patients received only Bevacizumab treatment. Panitumumab and Cetuximab mAb treatment was mostly taken in the 1st lines(69.6%, 76.9%, respectively). A statistically significant difference was found between the OSs of the cases according to the mAb treatment received(p=0.001). Administration of Panitumumab and Cetuximab mAb in the 1st or 2nd series didn’t make a significant difference to PFS.Discussion: The distribution of Panitumumab and Cetuximab mAb treatments was found to be balanced. They were preferred to give it in the first line. Patients who received anti EGFR mAb treatment had longer OS and PFS duration than those who received anti VEGF mAb only. It can be said that taking anti EGFR mAb treatment(being KRAS WT) has a positive effect on prognosis.
      PubDate: Sat, 29 Oct 2022 00:00:00 +030
  • Comparison of the pregnant and non-pregnant women of reproductive age
           hospitalized due to COVID-19 infection.

    • Authors: Özgür KILIÇ; Mehmet POLAT, Tibel TUNA, Eda KOPRU, M ELMALİ, İlkay BOZKURT, Davut GÜVEN, Melda DİLEK
      Abstract: COVID-19 affects pregnant women more severely than nonpregnant women of reproductive age. However, the rate of critical illness and fatality reported from other studies varied in a wide range in both groups. The study aims to investigate the clinical outcomes of COVID-19 in the pregnant and nonpregnant matched control patients admitted to the hospital. Pregnant and non-pregnant patients of reproductive age (18-45 years) infected with COVID-19 who were admitted to Ondokuz Mayıs University Hospital, Samsun, Turkey, from March 11 to December 11, 2020, were enrolled in the study. The clinical, radiological, and laboratory data of the patients were analyzed retrospectively. A total of 153 patients were investigated; 123 were nonpregnant and 30 were pregnant. Emergency delivery occurred in 5 (17%) pregnant women due to acute respiratory failure associated with COVID-19, and in 1 (3%) pregnant due to obstetric reasons. Four premature births, one perinatal death, and no stillbirth or miscarriage were reported. The rate of admission to the intensive care unit (ICU) [7/30 (23.3%) vs 3/123 (2.4%), p
      PubDate: Sat, 29 Oct 2022 00:00:00 +030

    • Authors: Fulya KÖSE; Bülent GÜNGÖRER, Hanifi ARSLAN, Abdullah Sadık GİRİŞGİN, Zerrin Defne DÜNDAR, Merve GÜVEN
      Abstract: AimThe aim of this study is to investigate whether the follow-up of patients on a mechanical ventilator using a tissue oxygenation device is superior to that using an O2 saturation probe.MethodOur study was conducted at the Necmettin Erbakan University Meram Medical School Emergency Medicine Critical Care Unit between 01/04/2016 and 01/06/2016. Patients over the age of 18, non-pregnant, and followed up on mechanical ventilators were prospectively recruited, and the saturations of the patients with tissue oxygenation devices and pulse oximetry were evaluated and compared. SPSS (ver. 19.0) was used for the statistical analysis of the collected data, and the descriptive measures of all the obtained variables were calculated.ResultsThe collected data revealed a statistically significant positive correlation between oxygen saturation measured by pulse oximetry and tissue oxygen saturation (StO2) in the patient group (n = 53), in which deceased and discharged patients were evaluated together. Both the hemoglobin levels and StO2 were low in the sepsis patients.ConclusionIt is important to follow tissue perfusion in intensive care patients, and this can be done with a noninvasive method. The results of our study reveal that perfusion should be followed with tissue oxygenation in patients on mechanical ventilators because low tissue oxygenation indicates increased patient mortality.
      PubDate: Sat, 29 Oct 2022 00:00:00 +030
  • Marginal ulcer after mini gastric by-pass and sleeve gastrectomy with
           transit bipartition

    • Authors: Muzaffer AL
      Abstract: The aim of this study to present the incidence of marginal ulcer among patients who underwent laparoscopic mini gastric by-pass (MGBP) or laparoscopic sleeve gastrectomy with transit bipartition (SG-TB), and to determine demographic, clinical and surgical risk factors associated with marginal ulcer development. This case-control study was designed as a retrospective analysis of an SG-TB and MGBP surgical series. The marginal ulcer group consisted of 8 patients who developed marginal ulcers during their follow-up. The control group was formed with a randomly selected sample of 18 people matching according to age, sex and operation type among the remaining 626 patients. The median age of all patients included in the study was 51 (27-62) years. 75.0% of the marginal ulcer group and 66.7% of the control group were males (p = 1.000). Marginal ulcer developed in 1.26% of all patients who underwent bariatric-metabolic surgery, in 6.45% of patients who underwent MGBP, and in 0.99% of patients who underwent SG-TB. It was observed that the ulcers of all cases recovered completely. No perforation was observed in any patient, no surgical intervention was required, and no marginal ulcer-related mortality was observed.There was no significant difference between the marginal ulcer group and the control group in terms of surgical, clinical and demographic features. Considering our practices and results, it was thought that post-operative PPI treatment for at least 6 months had a preventive effect on marginal ulcer development, and PPI treatment used after marginal ulcer development had an important role in healing.
      PubDate: Sat, 29 Oct 2022 00:00:00 +030
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