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SDÜ Sağlık Bilimleri Dergisi / SDU The Journal of Health Science
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  This is an Open Access Journal Open Access journal
ISSN (Print) 2146-1937 - ISSN (Online) 2146-247X
Published by Süleyman Demirel Üniversitesi Homepage  [4 journals]
  • Investigation of Escherichia coli O157:H7 in Raw Milk Offered for

      Abstract: Objective: Escherichia coli (E.coli) O157:H7 is one of the important causes of morbidity and mortality in terms of human health. Most infections due to E. coli O157:H7 are foodborne. In this study, it was aimed to determine the prevalence of E. coli O157:H7 in raw milk offered for consumption in Mersin.Materials and Methods: Sixty raw milk samples sold in various markets and grocery stores in Mersin provience were examined. Each milk sample was taken into a sterile container and brought to the bacteriology laboratory in the cold chain. 25 ml of milk samples were taken and inoculated into 225 ml of Tryptic Soy Broth, which was prepared for enrichment. After enrichment, it was cultured on MacConkey or Eozin Metilen Blue (EMB) agar. After the suspicious colonies that grew at the end of the incubation were confirmed as E. coli by IMVIC test, they were inoculated on Sorbitol-Mac-Conkey (SMAC) agar to investigate E. coli O157:H7. Antibiotic susceptibility test was performed by Kirby Bauer disk diffusion method according to Clinical and Laboratory Standards Institute (CLSI) guidelines to investigate the isolated isolates in terms of antimicrobial resistance profiles.Results: E. coli O157:H7 was isolated in two (3.3%) of 60 raw milk samples analyzed. E. coli O157:H7 isolates were found to be resistant to ampicillin and chloramphenicol, whereas only one isolate was resistant to gentamicin and ciprofloxacin, while the other isolate was susceptible. In addition, both isolates were found to be sensitive to tetracycline, nalidixic acid and cefuroxime.Conclusion: It was concluded that raw milk and dairy products may be a source for E. coli O157:H7 and pose a risk to public health.
      PubDate: Tue, 20 Dec 2022 00:00:00 +030
  • Design of Thymol Loaded Dental In Situ Gels; In Vitro Evaluation

    • Authors: Heybet Kerem POLAT; Sefa GÖZCÜ, Hüseyin AKŞİT
      Abstract: Objetive: The aim of the study was to develop thymol thermosensitive in situ gels based on poloxamers in order to prolong dental contact time, control drug release, and enhance dental bioavailability. Materials and Methods: Poloxamer 188 (P188) and poloxamer 407 (P407) were used in varying amounts to designed the in situ gels. Mucoadhesive excipient, like hydroxypropyl methylcellulose (HPMC), was transferred to the in situ gels to improve the formulation's ability to adhere to biological surfaces. For the created formulations, in vitro drug release, pH, clarity, and sol-gel transition temperature were all evaluated.Results: The all of in situ gels gelation temperatures of the developed formulations range from 33 to 37°C, pH values are around 7, and syringeability is defined as the amount of force necessary to discharge each formulation from a syringe fitted with a 20-gauge needle. The quantities of P407 and HPMC with the preparations, decreasing in vitro burst release while also increasing the viscosity but every in situ gel formulation releases for six hours. Conclusion:The results show that in situ gels containing P407 and P188 show promise for thymol dental application.
      PubDate: Tue, 20 Dec 2022 00:00:00 +030
  • Investigation of Entamoeba gingivalis and Trichomonas tenax in Patients
           with Periodontal Findings in Burdur Oral and Dental Health Center

    • Authors: Burcu ÖZDEMİR ÖĞRÜ; Mehmet Zeki YILDIRIM, Onur KÖSE
      Abstract: In the present study, it was aimed to determine the presence of Entamoeba gingivalis and Trichomonas tenax in individuals with periodontal disease who applied to Burdur Oral and Dental Health Center. Forty six patients with periodontal disease (30 gingivitis and 16 periodontitis) between the ages of 18-80 who applied to the Oral and Dental Health Center between April - November 2021 were included in this study. Supragingival dental plaque samples in the mouth of the patients were scraped with the help of a scaler. Trichrome staining was performed to examine the E. gingivalis, Giemsa staining was performed to examine the T. tenax, and samples were examined under a light microscobe. In the microscobic examination of the samples; E. gingivalis was detected in 25 patients (54.34 %), while T. tenax was not encountered in any of the samples. While there was no statistically significant difference betwen gender, age, tooth brushing habbits, smoking, systemic diseases, use of anticoagulant drugs and the presence of COVID-19 disease and E. gingivalis in the questionnaire (p > 0.05), a statistically significant difference was found between education status and the presence of E. gingivalis. As a result; one of the protozoans settled in the mouth E. gingivalis, has been detected widely, and it is thought that the prevalence of these parasites in different regions of Turkey should be determined and prevention and control methods should be developed with further studies to be carried out.  
      PubDate: Tue, 20 Dec 2022 00:00:00 +030
  • Examination of the Effect of Short-term Whole Body Vibration Training on
           Flexibility, Endurance and Dynamic Balance In Healthy Young People: A
           Randomized Controlled Study

    • Authors: Elif GUR KABUL; Bilge BAŞAKCI ÇALIK, Ummuhan BAŞ ASLAN, Fatma TAŞKIN
      Abstract: Objective: To investigate the effect of short-term (3 weeks) whole body vibration training (WBVT) in healthy young people. Materials and Methods: Seventy six healthy individuals (mean age=22.55±1.22 years, 41 females and 35 males) were included in the study. Participants were randomly divided into two groups as WBVT group (n=41) and control group (n=35). WBVT, consisting of 14 exercises for the trunk and lower extremities, was applied to the WBVT group 3 times a week for 3 weeks. The control group did not receive any training. Flexibility, lower extremity endurance, trunk endurance and dynamic balance respectively; measured with sit and reach test, sit and stand test, Biering Sorensen tests, lateral bridge and shuttle, Y balance test. All measurements were made at baseline and at the end of the 3rd week. Results: After 3 weeks, in WBVT group, curl up test (p=0.023), chair stand test (p=0.015) and Y balance test were perfomed on right anterior (p=0.003), right posteromedial (p=0.001), right posterolateral (p=0.001), left anterior (p=0.001), left posterolateral (p=0.000), and left posteromedial (p=0.000) aspects were significant. In the control group, the results in the right anterior (p=0.019) and left anterior (p=0.025) aspects of the Y balance test were significant. When the delta values were compared, the difference in the right (p=0.018) and left (p=0.006) posterolateral directions of the Y balance test; it was significant in favor of the WBVT group. Conclusion: It was observed that short-term whole body vibration training had positive effects on trunk flexor endurance and dynamic balance in healthy young people. New insights into the use of musculoskeletal rehabilitation and sports training programs can be provided by WBVT. Further studies are needed to examine the effectiveness of whole-body vibration training by comparing different loads, volumes and types.
      PubDate: Tue, 20 Dec 2022 00:00:00 +030
  • Comparison of Local Anesthetic Injection and Exercise Therapy Results in
           Patients with Chronic Cervical Myofascial Pain Syndrome

    • Authors: Handan Çağlar ÇAVDAR; Nihal BÜKER, Gülbüz SAMUT
      Abstract: Objective: The study was planned to evaluate patients with chronic cervical myofascial pain syndrome treated with lidocane injection and exercise and to compare the efficacy of treatments.Material and Method: The study included 73 patients (40 females, 33 males) aged between 25 and 65 years, who had been treated with exercise and lidocane injection due to the diagnosis of myofascial pain syndrome in our clinic 6 months ago, and volunteered to participate in the study. The mean age of the participants in the exercise group (n=38) was 44.16±10.63 years. The age of the participants in the lidokayn injection group (n=35) was 42.20±11.63 years. The exercise group was given stretching exercises for the neck and upper back muscles, and strengthening exercises for the neck muscles, 3 sets of 10 times a day. On the other hand, to the Lidokayn injection group participating in the study, 2 ml of 1% lidocaine was applied locally to the trigger points according to the injection technique defined by Travell and Simons. Patients' pain Visual Analogue Scale. pressure pain threshold Algometer, muscle spasm Palpable Muscle Spasm Scoring, cervical normal joint movement (CROM), disability level Neck Disability Scale, depression status Beck Depression Scale, anxiety status Beck Anxiety Inventory and quality of life SF-36 Short Form-36 scales. . Statistical significance level is (p<0.05).Results: The results of lidocaine ejection and exercise are similar in the treatment of MAS. We think that exercise therapy is more feasible in the treatment of MAS because it is non-invasive, easily applicable and more economical.
      PubDate: Tue, 20 Dec 2022 00:00:00 +030
  • Determination of Phytochemical Profile, Antiquorum Sensing and Antioxidant
           Activities of Tragopogon oligolepis

    • Authors: Ahu REİS; Tuğba MAZLUM ŞEN, Ebru ÖNEM, Özlem SARAL, Mutlu GÜLTEPE
      Abstract: Objective: In this study it was aimed to examine antiquorum sensing, antioxidant activities by using root and aerial parts extracts of Tragopogon oligolepis. Also phenolic content was detected using HPLC analysis.Material-Method: Antioxidant activity was detected by DPPH, FRAP methods and phenolic content HPLC. Antiquorum sensing activity was investigated by using pyocyanin and swarming motility assay on Pseudomonas aeruginosa PAO1. Results: Phytochemical profile findings showed that 12 components were detected in the root and 10 components in the aerial parts. The main components were found chlorogenic acid and o-coumaric acid. According to the obtained of antioxidant levels the aerial parts extracts of T. oligolepis had the best antioxidant property in our results. The amount of DPPH (0.60 ± 0.01 mg/ml) and phenolic content (6.55±0.18 mg GAE/g sample) was determined to be high in the aerial parts. In the FRAP analysis, high reducing power was found in the roots (12.62±0.36 μmol FeSO4/g sample). According to these results, although T. oligolepis extracts do not reach very high amounts in terms of antioxidant results, it is thought to be a plant that can be evaluated in terms of removing oxidant effects. The results of antiquorum sensing activity showed that both root and aerial parts extract showed strong inhibitory effect on swarming motility 62%, %65 rate respectively.Conclusions: Tragopogon oligolepis, an endemic species, can be evaluated as an antiquorum sensing inhibitor candidate with its phytochemical contents.
      PubDate: Tue, 20 Dec 2022 00:00:00 +030
  • In Vitro Genotoxicity of Rotenone in Human Lymphocytes

    • Authors: Dilek AŞCI ÇELİK; Vehbi Atahan TOĞAY
      Abstract: Objective: Rotenone is a lipophilic, broad-spectrum, insecticide and piscicide class pesticide that readily crosses cellular membranes. In this study, the effect of Rotenone on DNA of human peripheral blood lymphocytes was evaluated by the comet assay.Material-Method: In the study, peripheral blood lymphocytes taken from 8 volunteers, 4 male and 4 female, were treated with Rotenone at three different doses as 10, 50 or 100 µM, and for three different time periods of 1, 2 or 4 hours for each dose. Comet assay was applied and tail DNA percentage parameter was chosen as measure of DNA damage and statistically compared with negative and positive control groups.Results: Rotenone applications showed different results depending on incubation time and dose. Groups incubated with 10 or 50 µM Rotenone for 1 and 2 h caused an increase in DNA damage compared to the negative controls, but this increase was not statistically significant (p>0,05). There was a significant increase in DNA damage in the groups that were incubated with 10, 50 or 100 µM Rotenone for 4 h compared to the negative control group.Conclusion: When Rotenone exposure is short-term and at low doses, there is an increase in DNA damage, but this increase is not statistically significant. As the dose increases, statistically significant DNA damage also occurs in short-term exposures. Long-term exposure to Rotenone, on the other hand, shows significant DNA damage regardless of dose.
      PubDate: Tue, 20 Dec 2022 00:00:00 +030
  • A Comparison of the Short-Term Efficacy of Physiotherapy Approaches in
           Patients with Lateral Epicondylitis

    • Authors: Şahin ÇAKIR; Ayşenur TUNCER, Muhammed Furkan ARPACI, Mine ARGALI DENIZ
      Abstract: The study aimed to investigate the short-term effects of radial nerve self-mobilization [RNSM], manual therapy [MT], and extracorporeal shock wave therapy [ESWT] on pain, pain-free grip strength, functional status, and patient satisfaction in patients with Lateral Epicondylitis [LE] and to determine the superiority of these methods to each other. 48 patients diagnosed with LE were included in the study and were randomly divided into three groups. RNSM was applied to all patients as a home program. The first group [n=16] received only the RNSM as a home program, the MT group [n=16] received MT combined with RNSM, and the ESWT group [n=16] received ESWT combined with RNSM. The RNSM was applied five days per week, and the MT and ESWT for two sessions per week for three weeks. Pain severity, pain-free handgrip strength, functionality levels, and patient satisfaction were evaluated before and after three weeks of treatment. The pain level significantly decreased, and handgrip strength and functionality increased in all groups after three weeks [p<0.001]. In comparison between the groups, the decrease in pain level, the increase in maximum grip strength, and patients' overall satisfaction scores were found to be higher in the MT group than in the ESWT, and only the RNSM groups [p<0.05]. MT application combined with radial nerve self-mobilization exercises in the treatment of LE appears to be more effective.
      PubDate: Tue, 20 Dec 2022 00:00:00 +030
  • The Relationship between Loneliness and Life Satisfaction in Elderly
           People Living at Home

    • Authors: Fatma ARPACI; Ülkü POLAT, Giray KOLCU
      Abstract: Objective: This study was conducted to evaluate the relationship between loneliness and life satisfaction in elderly individuals living at home. Materials and Methods: The sample of the descriptive study consisted of 354 elderly individuals aged 60 and over, living at home in Ankara between January and March 2020. “Individual Information Form”, “Loneliness Scale for the Elderly”, “Life Satisfaction Scale” were used to collect data. Results: In this study, it was determined that the level of loneliness is higher in male, married and elderly individuals with low education level (p<0,05). it was determined that the life satisfaction was lower in the elderly who had low income, did not have social security and did not use social media. (p<0.05). In addition, there is a weak, positive (r:0.384,p:0.000<0.05) relationship between the mean scores of emotional loneliness sub-dimension of the elderly individuals and the mean scores of the life satisfaction scale, and a moderately negative relationship with the mean score of the social loneliness sub-dimension ( r:-0.437,p:0.000).Conclusion: This study showed that the level of life satisfaction and loneliness in elderly individuals differ according to some the descriptive characteristics and that social and emotional loneliness are associated with life satisfaction. In line with these results, it is recommended to increase social support for elderly individuals and to encourage the conscious and safe use of social media.
      PubDate: Tue, 20 Dec 2022 00:00:00 +030
  • Analysis of Genomic Data Sets by LASSO and Elastic Net Regression Methods

    • Authors: Merve VERGİLİ; Hikmet ORHAN
      Abstract: Objective: The purpose of this study is to show that large-sized genomic datasets can be reduced to smaller sizes using variable selection methods, and that analysis can be performed with less cost and time.Materials and methods: This study uses dataset number GDS4906, which is transferred from the NCBI database to the R program using Bioconductor. The dataset was analyzed using LASSO and Elastic Net regression methods with 10-fold cross-validation. Results: When the dataset is analyzed using the LASSO regression method, 5 genes were selected from the dataset and 2 genes were selected and the R2 values of the model were found as 0.85 by applying the determination selection method, as the variables and variable numbers selected in different iterations were then different. In the Elastic Net regression method applied using the interval search method, 19 genes were selected and R2 were found as 0.92.Conclusion: According to the results obtained, LASSO and Elastic Net regression methods have shown a good performance in the genomic datasets.
      PubDate: Tue, 20 Dec 2022 00:00:00 +030
  • Determining Nurses’ Professional Image Perceptions: A Descriptive
           Cross-Sectional Study

    • Authors: Merve TARHAN; Pınar DOĞAN, Esengül ELİBOL
      Abstract: Objective: The nursing image is built on a tripod of the public, nursing students, and nurses. Determining how each leg of this tripod perceives the nursing is crucial to improving the professional image. This study aimed to determine the nursing image perceptions among nurses at a private hospital group in Istanbul.Material-Method: This descriptive-cross-sectional study was carried out with 428 nurses at four private hospitals affiliated with a foundation university in Istanbul. Data were collected through a random sampling method using a self-administered questionnaire, including a personal information form, and The Image Scale for Nursing Profession. Data analysis was performed using descriptive statistics, Mann-Whitney U test, and Kruskal Wallis-H variance analysis. Results: Nurses generally perceived the nursing image as positive with a median score of 169 (160-177) out of 210. Nursing image for gender and professional status subscales was perceived more negatively than others, with median scores of 23 (19-28) and 19 (17-22), respectively. Nurses who were female (p=0.007), younger than 22 years (p=0.001), unwilling to re-choose nursing as a career (p=0.001), had professional experience less than a year (p=0.002), and worked more than 55 hours a week (p=0.000) perceived nursing image more negatively.Conclusion: The results of this study showed that nurses working at a private hospital group had positive perceptions of the nursing image at a high level, except in terms of gender and professional status. Reflecting a gender equality perspective on nursing management, employing only undergraduate nurses for nursing, and planning an effective work schedule are recommended.
      PubDate: Tue, 20 Dec 2022 00:00:00 +030
  • Serum Metalloproteinase-2 and Tissue İnhibitor Metalloproteinase-1 Levels

    • Authors: Mustafa GÜZEL; Orhan AKPINAR, Veysel Atilla AYYILDIZ, Mümtaz Cem ŞİRİN
      Abstract: Objectives: It was aimed to investigate the usability of MMP-2 and TIMP-1 levels as biomarkers in the oosteoarticular complications of brucellosis. Methods: The subjects were categorized into three groups as the healthy control group, brucella group, and brucella patients with osteoarticular involvement groups. Before medical treatment, serum samples from patients and control groups were stored at -80ºC until the day of study. MMP-2 and TIMP-1 serum levels were quantified by the ELISA method.Results: Serum level of MMP-2 (mean ± SD) in healthy control group was 1.71 +/- 0.10 ng / mL. Brucella patient group and Osteoarticular complıcation group were 14.3 +/- 2.52 ng / ml 20.65 +/- 2.33 ng / ml respectively (p=0.001). The mean TIMP-1 level in the control group was 3578.96 +/- 67.2 ng / mL, while in the Brucella group, this rate was 998.27 +/- 66.7 ng / mL and in the bone involvement group, 1656. 17 +/- 17.3 ng / ml. The difference between the control group and the brucella patients and the complicated group was statistically significant (p= 0.001). Conclusions: We think that the significant change in serum levels of MMP-2 and TIMP-1 when evaluated together with the radiological method, can be used as a biochemical indicator of the development of osteoarticular complications.
      PubDate: Tue, 20 Dec 2022 00:00:00 +030
  • Inactivation Of P. Aeruginosa Bacteria Using Vitamin B Complex and Red

    • Authors: Asiye YURTTAŞ; Kamil ÇINAR
      Abstract: In recent years, the phenomenon of anti-bacterial resistance has become more of a problem in combating diseases caused by bacteria. With this study, we aimed to inactivate Pseudomonas aeruginosa, an opportunistic pathogen of open wounds and burns, with a more effective method and to contribute to the development of photodynamic inactivation (PDI). We have shown that Pseudomonas aeruginosa bacteria are inactivated by vitamin B complex and laser with verifications of both spectrophotometric measurements and antimicrobial agent activity analysis. Moreover, the effect of PDI on bacterial growth was evaluated both qualitatively and quantitatively. Mortality rates were determined by comparing Escherichia coli and Pseudomonas aeruginosa strains. In the dark and light experiment of Escherichia coli bacterial strains at colony forming unit rates, a mortality rate of 20% was observed at 0.25 mg/mL and 0.125 mg/mL concentrations of vitamin B complex. In the dark experiment of Pseudomonas aeruginosa bacterial strains, a very low mortality rate was observed at 0.5 mg/mL and 0.125 mg/mL concentrations of vitamin B complex, while mortality rates after laser exposure were 60% and 50%, respectively. Flow cytometer viability experiments were performed to confirm these mortality rates and the results exhibited consistency with each other. In the light of this study; We predict that the red laser diode, together with the vitamin B complex, is a suitable candidate for the inactivation of Pseudomonas aeruginosa bacteria. This study will shed light on alternative treatment methods for the treatment of bacterial infections in the fields of hospital, medicine, and microbiology.
      PubDate: Tue, 20 Dec 2022 00:00:00 +030
  • Investigation of the Relationship between Smell and Sleep Quality in
           Medical Faculty Students

    • Authors: Arzu YALÇIN; Ülker TUNCA, Mustafa SAYGIN, Önder ÖZTÜRK, Sadettin ÇALIŞKAN, Yücel KURT
      Abstract: Objective: The relationship between sleep quality and odor in medical faculty students was investigated.Material-Method: Our study was approved by the clinical research ethics committee. In our cross-sectional study, socio-demographic characteristics questionnaire, Pittsburg sleep quality index (PUKI) and odor-sleep questionnaire were used to evaluate the sleep quality of the medical faculty students of our university.Results: Our work; 91 (46.9%) female students and 103 (53.1%) male students were included. The mean age of the students included in the study is 21.91±1.94, the income level of the students is 79 (42.2%) 1000 TL and above, 87 (44.8%) people live in apartments, 149 (76.8%) people smoke and 143 (73.7%) people do not use alcohol. 165 (86.4%) of the participants preferred to sleep in a dark environment. Of the students participating in the study, 160 (82.9%) were noise, 149 (77.2%) light, 145 (75.1%) the temperature level of the environment, 122 (63.2%) were physically in bed. structure, 107 (55.4%) polluted environment and 106 (54.9%) bad smell of the environment affected their sleep quality. 89 (45.9%) people agreed with the relationship between smell and sleep, and 70 (36.1%) people agreed with the relationship between smell and memory. The mean of the total PUKI scale in our study was found to be 12.88±5.60. There was a statistically significant difference between the time to sleep in term I and II students (p=0.040), and it was found that the time to sleep was prolonged in term II students. There was a significant difference in the duration of falling asleep between the students who participated in our study, between the semester II and the third semester students (p=0.017). The sleep quality of the students included in our study during falling asleep was found to be statistically significant (p<0,05).Conclusion: For a quality sleep, it is thought that there may be a connection between the smell and the sleep process.
      PubDate: Tue, 20 Dec 2022 00:00:00 +030
  • Is a Vegetarian Diet Safe to Follow During Childhood'

    • Authors: Aslı YİĞİT; Gülhan SAMUR
      Abstract: Vegetarianism is characterized by the exclusion of all animal flesh foods from the diet, including meat and fish. The more restricted form is a vegan diet that excludes all animal-derived food, including milk, dairy products, and eggs. During past decades questions have been raised about whether vegetarian diets are suitable during all stages of life and during the fast growth period. Nutrition during pregnancy and lactation is a potentially modifiable risk factor as it is an important determinant of lifetime disease risk. Therefore, it is of great importance to encourage mothers to have adequate and balanced nutrition during pregnancy and lactation. Infancy, childhood, and adolescence are critical periods, and nutritional requirements become crucial to be met during this time. Children on vegetarian diets might be at risk of certain nutrient deficiencies such as n-3 fatty acids, vitamin B12, iron, and zinc. Furthermore, the nutritional habits acquired during this period may influence dietary patterns and the risk of disease later in life. Most of the studies investigating the effect of vegetarian diets on children are outdated. There is a lot of controversy regarding the safety of vegetarian diets in childhood, and more longitudinal studies are needed. This review focuses on the effects of vegetarian diets in children and the health consequences of vegetarian diets.
      PubDate: Tue, 20 Dec 2022 00:00:00 +030
  • Overview of Primary Messengers and Their Receptors

    • Authors: Esma SELÇUK; Nilüfer ŞAHİN CALAPOĞLU
      Abstract: Signaling molecules play a key role in the transport of biological information between cells and in the formation of an appropriate response. When a signal molecule binds to its receptor, it initiates intracellular responses for the regulation of vital events such as cell proliferation, differentiation, movement, metabolism and behavior. The mechanism of action of intracellular signaling molecules is affected by the localization of the receptors. Receptors are proteins located in the membrane, cytoplasm or nucleus of the target cell, enabling the desired effect to occur. The first messengers synthesized for signaling bind to their receptors located in the cell or on the cell membrane, depending on their structure.When the ligand binds to the receptor, it changes the properties of the receptor and provides the necessary stimulation in the cell.
      PubDate: Tue, 20 Dec 2022 00:00:00 +030
  • Development Steps of a COVID-19 Gamification E-Learning Module for Nursing

    • Authors: Afra ÇALIK; Ridvan Bilal SAGLAM, Murat Gökhan KABAL, Betül ÇAKMAK, Bahar İNKAYA, Sevgisun KAPUCU
      Abstract: The interest in e-learning modules, which is one of the online teaching methods, has increased during the pandemic process. This article explains the development steps of the gamified e-learning module developed for nursing students. A collaborative, multidisciplinary project team consisting of an educational designer, two content experts, two consultants and a student was organized. The team developed an e-learning module using the D6 model of gamification. This module was designed online and asynchronously to increase the clinical skills and knowledge of undergraduate nursing students regarding COVID-19. Using gamified problem-based learning, which is used by integrating an e-learning module into nursing education, as a teaching material as theory and practice will contribute to the active participation of students, increase their motivation and effective learning.
      PubDate: Tue, 20 Dec 2022 00:00:00 +030
  • Investigation of Family Physicians' Attitudes and Behaviors Regarding
           Pre-Marriage Health Screenings in Isparta

    • Authors: Şerife ÜNVER; Gökçe İŞCAN, Funda YILDIRIM BAŞ
      Abstract: Objective: Preventive care includes premarital screening, which is included in preventive care and is crucial to ensure the continuation of healthy generations. This study's purpose was to educate and inform family physicians in the Isparta province about premarital screening.Material and Metot: Our cross-sectional, descriptive, analytical study was sent to all Family Physicians working in the province of Isparta using 'Google Forms' between February 15 and May 15 2021. 137 (87.8%) family physicians who responded to the questionnaires out of 156 currently working family physicians were included in the survey study. Results: Twenty-five percent of the doctors in our study stated they didn't always approve the marriage report. In terms of pre-marital examinations, VDRL (99.3%), hemogram (97.8%), and anti-HIV (97.8%) were the most often requested (p>0.05). Residents in the district showed a greater interest in infectious illness examinations (p=0.001).Discussion-Conclusion: The premarital counseling that can be given to spouse candidates throughout the premarital period, and the examinations to be requested within the scope of premarital screening, should be clearly organized and standardized. The legal component of premarital screening should be emphasized again in the content of the trainings, it was observed.
      PubDate: Tue, 20 Dec 2022 00:00:00 +030
  • Investigation Of The Antibiofilm Effects Of Cell-free Supernatants Of
           Probiotic Bacteria Against The Biofilm Formed By Bacteria Obtained From
           The Ocular Surface

    • Authors: Sertaç Argun KIVANÇ; Berna AKOVA BUDAK, Merih KIVANÇ
      Abstract: Objective: The aim of this study was to investigate the antibiofilm activity of the acellular filtrates of probiotic lactic acid bacteria on the biofilm produced by Listeria monocytogenes, Pseudomonas putida, Pseudomonas stutzeri, Stenotrophomonas maltophilia and Staphyloccocus epidermidis, isolated from the ocular surface. Material-Method: Lactobacillus rhamnosus 1743, Lactobacillus plantarum1771, Lactobacillus rhamnosus 3111, L. rhamnosus KA1 and L. rhamnosus 1724 were used as lactic acid bacteria. The purity of both lactic acid bacteria and pathogenic test bacteria was checked before use. Cell-free supernatant of lactic acid bacteria were passed through a 22µm filter. For the antibiofilm effect of the acellular filtrate, test pathogenic bacteria cultured in TSB medium were dispersed into the wells. After washing the wells, biofilm formation was evaluated spectrophotometrically at 570 nm according to optical density.Results: It was observed that acellular filtrates obtained from lactic acid bacteria inhibited biofilm formation at different rates in different test bacteria. The L. rhamnosus KA1 acellular filtrate was the filtrate that reduced the biofilms of all tested bacteria at most. It was also determined that the filtrates of lactic acid bacteria reduced the biofilm of P. stutzeri CZPX 23 at most. Conclusion: Cell-free supernatants obtained from probiotic lactic acid bacteria can help prevent biofilms formed by bacteria. The effects of acellular filtrates of different lactic acid bacteria on the biofilm formed by different test bacteria may vary. Further studies are needed for the detection and efficacy of a broad-spectrum lactic acid bacteria acellular filtrates.
      PubDate: Tue, 20 Dec 2022 00:00:00 +030
  • Clinical Significance of Spleen Size and Hematological Parameters in
           COVID-19 Patients

    • Authors: Pinar YÜRÜK ATASOY; Engin BEYDOĞAN
      Abstract: Objective: COVID-19, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), causes systemic involvement and the spleen may be one of the target organs. In this study, we aimed to evaluate the effect of spleen size and laboratory parameters in computed tomography (CT) sections taken during hospital admission of COVID-19 patients on the outcome of COVID-19.Material-Method: This retrospective cohort study included 644 COVID-19 patients admitted to our hospital between April and December 2020. The medical records of the patients were collected, and the thorax CT scans in which the entire spleen could be evaluated in the thorax CT sections taken at the time of admission were reviewed.Results: The study population included 644 patients (387 men, 257 women) with a median age of 59 (45 – 69 years). The three most common systemic diseases associated with COVID-19 were hypertension (28%), diabetes mellitus (22.2%), and heart disease (18.6%). The most common active complaints at admission were shortness of breath (57.5%) and cough (46%). 109 of 644 patients were mortal. At admission, patients with mortality had higher median leukocyte count (8.9 vs 6.5, p<0.001), lymphocyte count (1.3 vs 1.0, p<0.001) and platelet count (187 vs 200, p=0.001). 0.035) was higher in patients without mortality. Of the study population, 173 (26.9%) had splenomegaly, and the rate of splenomegaly was significantly higher in patients without mortality (31% vs. 6.4%, p<0.001).Conclusion: Although COVID-19 manifests itself with lung involvement especially in the early period, it also causes systemic involvement and one of the target organs may be the spleen. In addition, the lymphocyte, monocytes and platelet counts of the patients at the time of admission can predict the progression of COVID-19. The results of our study suggest that increased spleen size may be a marker that should be considered in terms of COVID-19 outcome.
      PubDate: Tue, 20 Dec 2022 00:00:00 +030
  • Approach and Behaviors of Healthcare Professionals in a Tertiary Hospital
           About COVID-19 Infection and Vaccination

    • Authors: Zeliha SALMAN; Hakan SALMAN, Mustafa AKÇAM
      Abstract: Objective: To determine the approaches and behaviors of healthcare professionals regarding COVID-19 disease and vaccination during the pandemic.Material-method: The study was carried out by collecting the answers of the healthcare professionals working at the hospital through WhatsApp application. This was done via 44-question survey questioning their approaches and behaviors regarding COVID-19 infection and vaccines between 1-31 March 2022.Results: 209 of 311 health workers participating in the study were female (67.2%). The median age was 36 years. Of the participants, 203 (65.3%) were university graduates and 159 (51.1%) were physicians. There were 51 persons (16.4%) with chronic disease. Of the healthcare workers, 141 (45.3%) had COVID-19 infection, and 176 (56.6%) had a family member with COVID-19 infection. There were 23 (7.4%) family members who stayed in the intensive care unit due to infection, and 22 (7.1%) whose family members died. At least one side effect developed in 211 (67.8%) of 304 (97.7%) healthcare workers who were vaccinated. The most common side effect was fatigue in 156 (73.9%) and the most common side effect was seen with Biontech (59.8%). If there was an option, 70.1% stated that Biontech vaccine would be their first choice. There were 131 (42.1%) people who relied on the Turkovac vaccine. The rate of those who thought that the vaccine should be mandatory in terms of public health was 83.3%, those who believed that the pandemic would end with the vaccine, 58.8%, and 80.4% believed that the number of patients would decrease. Among the reasons that increased indecision towards COVID-19 vaccines in healthcare workers, side effects of the vaccines was the most common concern with 74%. In the physician group, the rate of those who answered positively to the question of having their children vaccinated, the belief that the pandemic will end with the vaccine, the belief that the number of patients will decrease with the vaccine, and the question "Would you recommend vaccines to your relatives" was statistically higherConclusion: Among healthcare workers, the rate of being vaccinated against COVID-19 and confidence in Bionthec vaccine was high. The belief that the pandemic will end or the number of patients will decrease with the COVID-19 vaccine may be a factor in this high rate.
      PubDate: Tue, 20 Dec 2022 00:00:00 +030
  • The Evaluation of Incidentally Detected Head and Neck Region Soft Tissue
           Calcifications and Ossifications on Computed Tomography Images

    • Authors: Ezgi TÜRK; Veysel Atilla AYYILDIZ, Özlem GÖRMEZ
      Abstract: Aims: Unorganized accumulation of calcium stored in soft tissues is termed as heterotopic calcification, organized accumulation of it is termed as heterotopic ossification. The aim of this study was to evaluate retrospectively all head and neck region soft tissue calcifications/ossifications that are detected incidentally on computed tomography (CT) images of Turkish patients and to analyze them according to age and gender. Methods: CT images of 917 patients were retrospectively analyzed in terms of the presence of head and neck soft tissue calcification/ossification, and demographic characteristics (age and gender) of the patients were recorded. The data were analyzed with descriptive statistical methods and the relationship between soft tissue calcification/ossification and gender was evaluated with the chi-square test.Results: Soft tissue calcification/ossification was detected on CT images of 214 (mean age= 61.35±14.7 years, 50.5% female, 49.5% male) of 917 patients examined (23.3%). Among the calcifications/ossifications detected, tonsillolith (n=120, 56.1%), arterial calcifications (n=61, 28.5%) and sialolith (n=15, 7%) were determined in the first three rows. Tonsillolith was significantly more common in female and ossified stylohyoid ligament (OSL) was significantly more common in male (p<0.05).Conclusions: Soft tissue calcifications/ossifications can be detected incidentally in radiographic images taken from head and neck region for various purposes. In the study, tonsillolith was the most common soft tissue calcification on CT images. It was found that the tonsillolith was statistically higher in female, and the OSL in male. These calcifications/ossifications were most frequently found in patients over age 40.
      PubDate: Tue, 20 Dec 2022 00:00:00 +030
School of Mathematical and Computer Sciences
Heriot-Watt University
Edinburgh, EH14 4AS, UK
Tel: +00 44 (0)131 4513762

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