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Journal of Biochemistry and Molecular Biology Research
Number of Followers: 1

This is an Open Access Journal

Open Access journal
ISSN (Print) 2313-7177
Published by ACT Publishing Group Ltd

[11 journals]

Oxidative stress and Aging: changes in important cell signaling pathways
- Authors: Filipe Nogueira Franco
  Abstract: Important cellular signaling pathways control the basal metabolism in mammalian cells, mainly in combating oxidative stress. Several studies have correlated the increase in ROS as one of the causes of aging. However, some authors also point out that cell aging causes an increase in ROS, mainly due to the inhibition of important antioxidant pathways. Important pathways of protein kinases and transcription factors are important to combat the accumulation of ROS, promoting an increase in mitochondrial biogenesis, synthesis of antioxidant enzymes and decreasing cellular senescence. In this review, the fundamental roles of the SIRTs, AMPK, MAPK, FOXO and Nrf2 pathways are highlighted.
  PubDate: 2021-01-25
  Issue No: Vol. 2021 (2021)

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