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Pediatric Annals
Journal Prestige (SJR): 0.306  Number of Followers: 4  Subscription journalISSN (Print) 0090-4481 - ISSN (Online) 1938-2359 Published by Healio  [3 journals]
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- Lebrikizumab effective against moderate-to-severe atopic dermatitis,
trials find-
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Authors: Rose Weldon
Abstract:
Two phase 3 trials found that lebrikizumab was effective against moderate-to-severe atopic dermatitis in adolescents and adults, researchers reported in The New England Journal of Medicine.
“Lebrikizumab is a whole monoclonal antibody that targets interleukin-13, which has been shown to be important in the pathogenesis of atopic dermatitis,” Jonathan I. Silverberg, MD, PhD, MPH, director of clinical research and an associate professor of dermatology at the George Washington University School of Medicine and Health Sciences, told Healio.
Silverberg and colleagues conducted a pair of
PubDate: Fri, 24 Mar 2023 19:35:55 Z
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- Declining hemoglobin linked with growth impairment among children with CKD
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Authors: Julie S. Keenan
Abstract:
Over time, a declining hemoglobin z score correlates with impaired height among children with mild to moderate nonglomerular chronic kidney disease, according to data published in the American Journal of Kidney Diseases.
Moreover, investigators found impaired growth occurs even before hemoglobin levels reach the threshold used to define anemia in children.
“Both anemia and short stature are common complications of CKD in children. In children without CKD, anemia has been shown to impair physical development; however, the relationship between anemia and growth in children with CKD remains
PubDate: Fri, 24 Mar 2023 16:21:44 Z
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- World TB Day: Is TB vaccine and treatment research back on track'
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Authors: Caitlyn Stulpin
Abstract:
Throughout the COVID-19 pandemic, World TB Day, which is observed each year on March 23, has marked the need for more — more research, more testing, more treatment options, and more access for patients globally.
This year, more is still needed, although fortunately, David L. Cohn, MD, Infectious Disease News Editorial Board Member and professor of medicine in the division of infectious diseases at the University of Colorado School of Medicine, said TB treatment and vaccine research are both picking up momentum after being hindered in many places worldwide.
Healio spoke with Cohn and Maria
PubDate: Fri, 24 Mar 2023 15:16:19 Z
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- Q&A: In utero exposure to Bendectin linked to increased risk for CRC
in adult offspring-
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Authors: Kate Burba; Caitlin C Murphy; PhD, MPH
Abstract:
Prenatal exposure in the 1960s and ’70s to dicyclomine, a component of the anti-nausea drug Bendectin, increased the risk for colorectal cancer in adult offspring, according to data reported in JNCI Cancer Spectrum.
“In the 1960s, Bendectin (doxylamine/pyridoxine/dicyclomine) was frequently prescribed to pregnant women to manage nausea and vomiting. Bendectin was initially approved in 1956 and quickly became the most common treatment for nausea or vomiting of pregnancy in the U.S as its use grew in the 1960s and ’70s,” Caitlin C. Murphy, PhD, MPH, associate professor at
PubDate: Fri, 24 Mar 2023 11:00:00 Z
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- MIS-C outcomes with glucocorticoids alone similar to IVIG, combination
therapy-
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Authors: Erich Martin
Abstract:
Glucocorticoids alone demonstrate similar recovery rates as intravenous immunoglobin, or combination therapy with both, in patients with multisystem inflammatory syndrome in children, according to data published in The Lancet Rheumatology.
“In the absence of evidence from randomized controlled trials, treatment recommendations for the newly recognized disease were developed by clinical consensus in many countries,” Samuel Channon-Wells, MMath, of Imperial College London, and colleagues wrote. “Based on the similarity of MIS-C to Kawasaki disease, for which intravenous
PubDate: Thu, 23 Mar 2023 20:30:00 Z
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- Teen girl presents with recurring sores
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Authors: James H. Brien; DO
Abstract:
You are asked to see a 14-year-old girl for recurrent, draining sores in the bilateral groin areas for over a year. She did not want to tell her parents, fearing what they might think, even though she was not sexually active.
The lesions occur in cycles that begin with an erythematous papule and progress to an abscess and spontaneous drainage, then may continue to drain, either forming a sinus tract or heal over (Figure 1). The sores do not occur anywhere else on her body. When she finally told her mother, she was taken to her primary care physician, who cultured a draining lesion, growing
PubDate: Thu, 23 Mar 2023 20:09:01 Z
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- TB on rebound in US, but cases remain below pre-pandemic levels, CDC says
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Authors: Caitlyn Stulpin
Abstract:
Cases of tuberculosis increased in the U.S. in 2022 but did not return to pre-pandemic levels, according to data published in a Morbidity and Mortality Weekly Report ahead of World TB Day.
“During the early COVID-19 pandemic (2020), U.S. incidence of reported TB substantially declined. Incidence partially rebounded in 2021 but remained lower than incidence during pre-pandemic years,” Kimberly R. Schildknecht, SnD, BSN, MPH, Epidemic Intelligence Service officer, and colleagues wrote.
They attributed these declines to delayed or missed TB diagnoses, changes in migration and travel
PubDate: Thu, 23 Mar 2023 19:07:15 Z
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- Children who skip the ED after anaphylaxis during OIT use epinephrine at
home-
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Authors: Richard Gawel
Abstract:
SAN ANTONIO — Children on OIT who used epinephrine to treat anaphylaxis went to the ED less often than those who did not use epinephrine, according to data presented at the American Academy of Allergy, Asthma & Immunology Annual Meeting.
“Prompt use of epinephrine is recommended to treat anaphylaxis,” Sofianne Gabrielli, MSc, MDCM candidate with the division of experimental medicine, Faculty of Medicine, McGill University, said during her presentation.
However, Gabrielli continued, data on the obligatory need to present to the ED after epinephrine use in treating
PubDate: Thu, 23 Mar 2023 18:49:00 Z
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- Autism prevalence rises in US amid shift in demographics
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Authors: Rose Weldon
Abstract:
The prevalence of autism among 8-year-olds in the United States rose to approximately one in 36 children in 2020 amid a shift in the demographic makeup of children diagnosed with the condition, according to data published Thursday.
Data from the same network published in 2021 indicated that the prevalence of autism had risen to one in 44 children in 2018 amid progress in early detection. Other reports have also signaled a rise in diagnoses among children and teenagers.
A second report published Thursday found that 4-year-old children were less likely to be evaluated for or identified with
PubDate: Thu, 23 Mar 2023 17:11:31 Z
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- EULAR: Tocilizumab recommended for new, relapsing giant cell arteritis
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Authors: Erich Martin
Abstract:
Weekly tocilizumab 162 mg is recommended for giant cell arteritis in new or relapsing cases, alongside glucocorticoids that should eventually be tapered, according to an updated EULAR consensus statement on interleukin-6 inhibitors.
The update expands EULAR’s recommendations for the IL-6 pathway beyond rheumatoid arthritis and juvenile idiopathic arthritis, into GCA, Takayasu arteritis, adult-onset Still’s disease, chimeric antigen receptor-T-cell-induced cytokine release syndrome, severe COVID-19 and other conditions.
“At the time of the first consensus statement on IL-6 and
PubDate: Thu, 23 Mar 2023 09:30:00 Z
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- Tech-dependent pediatric patients travel greater distances for care
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Authors: Rose Weldon
Abstract:
Families caring for children with technology dependence are more likely to travel long distances for medical care, routinely bypassing closer hospitals to access facilities with more capabilities, researchers reported in Pediatrics.
Children with technology dependence (CTD) include those with ventricular shunts, gastrostomy or tracheostomy — “a subset [that] are among the most prevalent and most commonly associated with admissions,” the authors of the new study wrote.
“Although it remains unclear how often CTD access emergency departments in their communities, it is
PubDate: Wed, 22 Mar 2023 19:53:46 Z
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- FDA OKs obstructive sleep apnea nerve stimulator for pediatric patients
with Down syndrome-
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Abstract:
The FDA approved an obstructive sleep apnea neurostimulation therapy for patients aged 13 years and older with Down syndrome, according to a manufacturer-issued press release.
According to an FDA Roundup news release, the Inspire II Upper Airway Stimulator system (Inspire Medical Systems Inc.), a device placed inside a patient’s body, is now approved for patients with severe OSA and Down syndrome aged 13 years and older.
This device was previously approved for patients with moderate to severe OSA aged 22 years or older in 2014 and for patients with the same OSA severity level aged 18
PubDate: Wed, 22 Mar 2023 19:16:34 Z
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- Suicide-related ED visits increased among children, adolescents during
pandemic-
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Authors: Kalie VanDewater
Abstract:
ED visits for suicide attempts and suicidal ideation increased among children and adolescents during the COVID-19 pandemic, according to data published in The Lancet Psychiatry.
The findings suggest that mental health resources available through community health programs and the education system are “urgently needed” to support this population, Sheri Madigan, PhD, and colleagues wrote.
Madigan, a professor in the department of psychology at the University of Calgary and the Alberta Children’s Hospital Research Institute in Alberta, Canada, and colleagues reviewed databases to
PubDate: Wed, 22 Mar 2023 15:38:00 Z
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- Givinostat improved mobility, physical function in boys with Duchenne
muscular dystrophy-
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Authors: Robert Herpen; MA
Abstract:
Treatment with givinostat was associated with improvement in mobility and physical function compared with placebo in ambulant boys with Duchenne muscular dystrophy, according to a poster at the 2023 MDA Clinical & Scientific Conference.
“Givinostat is a novel orally active histone deacetylase inhibitor being developed for the treatment of [Duchenne muscular dystrophy],” Eugenio Mercuri, MD, PhD, professor of pediatric neurology and head of the pediatric neurology and psychiatry unit at Gemelli Hospital Catholic University Foundation in Rome, and colleagues wrote.
Seeking to
PubDate: Wed, 22 Mar 2023 14:58:46 Z
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- High-flow nasal cannula bronchiolitis treatment outside ICU tied to long
stays, high costs-
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Authors: Isabella Hornick
Abstract:
Pediatric patients with bronchiolitis who are admitted to hospitals that use more high-flow nasal cannula outside the ICU face longer stays and greater total costs, according to study results published in Hospital Pediatrics.
“It is important for hospitalists and other clinicians caring for children with bronchiolitis to be mindful about the initiation of high-flow nasal cannula (HFNC) in these patients,” Jeffrey C. Winer, MD, MA, MSHS, FAAP, associate professor of pediatrics and associate fellowship program director of pediatric academic hospital medicine at the University of
PubDate: Wed, 22 Mar 2023 12:06:54 Z
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- CMS prior authorization proposal is ‘a good start’ but may not
go far enough-
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Authors: Andrew Rhoades
Abstract:
The proposal would require shorter approval times and implementation of a standard application programming interface to support electronic processes.
The AMA and 118 other leading medical societies recently announced that they have united in support of CMS’ prior authorization reform proposal.
The proposal would require certain payers to implement an electronic prior authorization process by 2026, while also needing to shorten the time frame in which they send responses.
Specifically, the CMS proposal would require the implementation of a “Health Level 7 (HL7) Fast Healthcare
PubDate: Tue, 21 Mar 2023 20:13:37 Z
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- Area deprivation tied to youth hypertension in Medicaid recipients
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Authors: Erik Swain
Abstract:
Among Medicaid-insured youths from Delaware, higher childhood neighborhood area deprivation index score was associated with hypertension diagnosis, researchers reported.
“Improving cardiovascular health means understanding what contributes to risk factors for cardiovascular disease when it begins in childhood. Hypertension is a primary risk factor for heart disease. In this study, we wanted to explore the relationship between a composite of the neighborhood-level deprivation (eg, education levels, income, housing, etc) and hypertension in children,” Carissa M. Baker-Smith, MD, MPH,
PubDate: Tue, 21 Mar 2023 13:32:23 Z
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- Record number of primary care positions offered in 2023 Match Day
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Authors: Andrew Rhoades
Abstract:
A record-high number of positions in primary care were offered in the 2023 Main Residency Match, according to the National Resident Matching Program, or NRMP.
“We were excited to see the record number of primary care positions offered in this year’s Match and how the number of positions has consistently increased over the past 5 years, and most importantly, the fill rate for primary care has remained steady,” NRMP President and CEO Donna L. Lamb, DHSc, MBA, BSN, said in a press release.
Overall, 571 more primary care positions were offered compared with 2022, representing an
PubDate: Mon, 20 Mar 2023 21:27:17 Z
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- FDA allows higher dose of investigational drug in study of children with
Dravet syndrome-
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Abstract:
Stoke Therapeutics Inc. announced the FDA will allow administration of a higher single dose of its investigational drug STK-001 in its ongoing phase 1/2a MONARCH study of children and adolescents with Dravet syndrome.
According to a release from Stoke, the new 70 mg single dose cohort in the MONARCH study will complement the evaluation of multiple doses of 70 mg in the ongoing ADMIRAL study. With no currently approved disease-modifying therapies for Dravet syndrome, the novel antisense oligonucleotide STK-001 has the potential to become the first to address the genetic cause of Dravet
PubDate: Mon, 20 Mar 2023 19:57:26 Z
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- Private equity in health care continues to grow
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Authors: Alex Young
Abstract:
Private equity has had a long involvement with and continues to stay active in the business of health care.
In a panel discussion at the University of Pennsylvania’s Leonard Davis Institute of Health Economics, Rachel M. Werner, MD, PhD, executive director at the institute, said the number of private equity deals in health care has increased from 325 in 2010 to more than 1,000 in 2021.
“Private equity firms have invested nearly $1 trillion through thousands of deals to acquire hospitals and specialized practices in the last decade alone,” she said.
The driving force behind
PubDate: Mon, 20 Mar 2023 19:48:00 Z
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