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Journal of Contemporary Medicine
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ISSN (Print) 2146-4189 - ISSN (Online) 2667-7180
Published by Selcuk University Homepage  [6 journals]
  • Distribution of Clinical Staphylococccus aureus Isolates and Antibiotic
           Resistance Profile: Three-Year Data

    • Authors: Ali Korhan SIĞ; Alev ÇETİN DURAN, Tuğba KULA ATİK, Nermin ÖZEN, Onur IRMAK, Muradiye YARAR
      Abstract: Objective: Staphylococci cause community-acquired and hospital-acquired infections, and Staphylococcus aureus is one of leading agents. In the last decades methicillin-resistant S.aureus (MRSA), vancomycin-intermediate S.aureus (VISA) and vancomycin-resistant S.aureus (VRSA) became as major concerns. Resistance to other antibiotics is also another growing issue. The aim of this study was to investigate the prevalence of S.aureus species and to evaluate susceptibilities to antimicrobial agents in a state (tertiary) hospital.Methods: Clinical cultures from various samples (urinary tract, respiratory, wound, abscess, tissue, catheter and external auditory) obtained from January 2017 to December 2019 in XXX hospital were included in the study. Isolated S.aureus strains and their antibiotic susceptibilities were retrospectively evaluated.Results: A total of 765 S.aureus strains were isolated. 165 S.aureus strains were found as methicillin resistant (MRSA; 21.9%). There was not any statistically significant difference in MRSA rates among evaluated years (p=0.772). There was not any strain that was resistant to vancomycin, teicoplanin and/or linezolid. The highest rate was observed in penicillin resistance (n=646/728, 88.7%). There was not any statistically significant alteration in the resistance rates of all tested antibiotics during the three-year period.Conclusions: Despite dwindling MRSA rates in UAMDSS, CAESAR report indicates that Turkey seems to be in the beginning phase of this struggle. Local and/or national antimicrobial stewardship programs are in effect in Turkey, but further measures are required.
      PubDate: Wed, 30 Nov 2022 00:00:00 +030
       
  • Evaluation of Hemostasis Parameters in Adolescent Girls Presenting with
           Menometrorrhagia and Comparison with Healthy Adolescents

    • Authors: Ayşe Esra TAPCİ; Serçin TAŞAR, Bulent ALİOGLU, Yıldız DALLAR BİLGE, Nermin DİNDAR BADEM
      Abstract: Objective: This study aims to investigate the presence of acquired and hereditary coagulation in adolescent girls presenting with increased menstrual bleeding.Method: The study consisted of 63 adolescent female patients (15.4±1.5 years) who applied to the pediatric clinic of our hospital due to increased menstrual bleeding, did not have any acute or chronic disease, did not use any medication in the last 14 days, and were of the same age and gender as the study group. 74 healthy adolescents were taken as the healthy control group (15.5±1.5 years). Platelet count, all basal and advanced coagulation tests, platelet aggregation, and secretion tests were studied for each case included in the study.Results: When basal and advanced coagulation tests, platelet aggregation, and secretion tests were examined, no significant difference was found between the study and the healthy control group. On the other hand, in our study group with heavy menstrual bleeding, 4 (6.3%) patients were found to have impaired hemostasis (2 patients with type 1 von Willebrand disease, one patient with immune thrombocytopenic purpura, and one patient with mild factor VIII deficiency).Conclusion: Various hemostasis disorders, especially von Willebrand disease, could be detected in the group with heavy menstrual bleeding.
      PubDate: Wed, 30 Nov 2022 00:00:00 +030
       
  • NTRK Somatic Fusions and Tumor Agnostic Treatment in Pediatric Cancers

    • Authors: Sonay İNCESOY ÖZDEMİR; Ayça Yağmur ŞİMŞEK, Emel ÜNAL
      Abstract: Neurotrophic tyrosine receptor kinase (NTRK) gene rearrangements have been recently identified and developed as one of the biomarkers that have been utilized as new targets for cancer therapy. NTRK gene fusions have taken their place in individualized targeted therapy by being used as a predictive (diagnostic) biomarker as well as a treatment target. Selective inhibitors of NTRK fusion proteins have potent efficacy in the treatment of NTRK fusion-positive solid tumors. Detection of these fussions have become important since the finding of new drugs for which U.S. Food and Drug Administration (FDA) granted approval are used on the treatment of patients who has NTRK fussions positive cansers. Clinical trials have shown that first generation tyrosine receptor kinase (TRK) inhibitors, larotrectinib (Vitrakvi, Bayer HealthCare Pharmaceutical Inc, New Jersey, U.S.) and entrectinib (Rozlytrek, Genentech Inc, California, U.S.), have potent efficacy in the treatment of NTRK fusion positive cancers. In the future, with the increase in the number of comprehensive studies on these drugs further information will become available and beneficial.
      PubDate: Wed, 30 Nov 2022 00:00:00 +030
       
  • Association between Triple-Negative Breast Cancer and Socioeconomic and
           Cultural Factors in Southeast Anatolia: A Single-Center Experience

    • Authors: Hilal ALKIŞ; Abdurahman KUZHAN
      Abstract: Objective: Triple-negative breast cancers (TNBCs) are associated with younger age, advanced stage at diagnosis, ethnicity, lower socioeconomic status (SES), and poor prognosis. The aim of the study was to investigate clinicopathologic features of TNBC patients living in Southeastern Anatolia, and the association between socioeconomic and cultural factors and TNBC. Material and Methods: A total of 875 women were included in the study. The effects of socioeconomic factors and cultural factors on clinicopathologic features of TNBC patients were evaluated. The SES of the patients was categorized as lower and higher according to educational and health insurance status, and household income. Patients’ age at diagnosis, living area (rural or urban), SES, and ethnicity (Arabic, Armenian, Kurdish, and Turkish) were recorded. Results: Median age was 47 (20-85) and 10% (n=87) of the patients were diagnosed TNBC. TNBC rates were higher in patients ≤40 years. Younger age, lower SES, and Arabic and Kurdish ethnicities were associated with higher rates of TNBC. Conclusion: Although the majority of the breast cancer patients in our region were premenopausal, the rate of TNBC among them was found to be lower than the general rate of western countries. Socioeconomic and cultural factors may affect tumor biology and prognosis of the disease in patients with TNBC. In our study, younger age, lower SES, and ethnicity were found to be associated with higher rates of TNBC and worse prognosis.
      PubDate: Wed, 30 Nov 2022 00:00:00 +030
       
  • Demonstration of the Effectiveness of Epidermal Growth Factor in Diabetic
           Foot Ulcers

    • Authors: Halit BAYKAN; Mehmet KARA
      Abstract: Purpose: Diabetes affects more than 170 million people over the age of 20 worldwide. Diabetic foot ulcers (DFU) are one of the most common complications of diabetes. It negatively influence the patients' quality of life. Multidisciplinary treatment is required in the treatment of DFUs. In our study, we aimed to investigate the effectiveness of intralesional epidermal growth factor (EGF) in diabetic neuropathy foot ulcers.Materials and Methods: The study was conducted with 29 patients who applied to our clinic due to diabetic foot wounds between January 2014 and December 2020, who had no wound infection and osteomyelitis, who underwent EGF in accordance with the study criteria. In our study, EGF of 75µg/day 3 times a week was applied intralesionally to diabetic ulcers for 4-8 weeks.Results: A total of 29 patients were included in the study. 21 of the patients were male and 8 of them were female. The mean age was 59,82. One patient had signs of osteomyelitis. Additional disease was detected in 93,1% of the patients. The mean ulcer width of the patients was found to be 3,44 cm2.Conclusion: Three important results were obtained from the study. First; epidermal growth factor has been quite effective in the treatment of patients with DFU. The second important finding was to ensure the safe epithelialization of the standing ulcers without impairing the quality of life of the patients. Thirdly, after debridement, treatment with EGF was found to provide a significant improvement in wounds.
      PubDate: Wed, 30 Nov 2022 00:00:00 +030
       
  • The role of combined hematological inflammatory indices in predicting poor
           outcomes in patients with acute pancreatitis

    • Authors: Abuzer ÖZKAN; Hatice Şeyma AKÇA
      Abstract: AimThe aim of the instant study is to evaluate the predictability of AISI, NLPR, and SIRI in patients with acute pancreatitis, which predicts more than 7 days of hospitalization, the need for intensive care, and 30-day mortality.Material and MethodThis retrospective observational study was conducted in patients diagnosed with acute pancreatitis who applied to the emergency medicine clinic of XXX Hospital between July 15, 2017 and February 15, 2021.Statistical analysis was performed using SPSS v. 26.0.ResultsThe study included 592 patients, 58.3% of which were women. A statistically significant difference was found between high NLPR, and hospital stay longer than 7 days (p = 0.01). No statistically significant correlation was found between AISI and SIRI and the length of hospital stay (p = 0.16, p = 0.19, respectively). There was a statistically significant correlation between high NLPR, and mortality (p = 0.03). No statistically significant correlation was found between AISI, SIRI, and mortality (p = 0.866, p = 0.311, respectively). There was a statistically significant correlation between high NLPR, and hospitalization in the intensive care unit (p = 0.018) No statistically significant relationship was found between AISI, SIRI, and admission to the intensive care unit (p = 0.89, p = 0.6, respectively).ConclusionAcute pancreatitis is an inflammatory process that requires serious approach. Hematological parameters are helpful in predicting the prognosis, but there is a need for differently developed hematological indices in managing acute pancreatitis.
      PubDate: Wed, 30 Nov 2022 00:00:00 +030
       
  • Association of systemic immune-inflammation index with long-term all-cause
           mortality in pancreatic cancer patients after pancreaticoduodenectomy

    • Authors: Aziz Ahmet SUREL; Serap ULUSOY, Muhammet Kadri ÇOLAKOĞLU
      Abstract: Aim: Systemic immune-inflammation (SII) index may provide more promising prognostic information in patients with cancer surgery. However, to the best of our knowledge, the prognostic value of SII index in patients with pancreatic cancer who underwent pancreaticoduodenectomy has not been studied. Thus, this study aimed to evaluate and compare the prognostic value of SII index in patients with pancreatic cancer who underwent pancreaticoduodenectomy.Materials and Methods: All patients over 18 years-old that underwent successful pancreaticoduodenectomy due to pancreatic cancer between February 20, 2019 and June 30, 2021 at Ankara City Hospital Department of General Surgery were included. The main predictor of interest was SII index which was measured by neutrophil*platelet / lymphocyte count. The main outcome of the study was long-term all-cause mortality.Results: A total of 223 patients were included in the current study. Multivariable cox regression analysis revealed that history of congestive heart failure [HR (95%CI): 3.682 (1.140-11.892)], and SII index [HR (95%CI): 1.001 (1.001-1.001)] were independently associated with all cause long-term mortality. The accuracy of predicting mortality for SII index was assessed by the area under the ROC curve which was = 0.77. A higher value of 1305 of SII index was found with 76% sensitivity and 67% specificity for predicting all-cause long-term mortality.Conclusions: The results of the study suggest that measurement of the SII index, an easily available and relatively cheap marker, is an independent predictor of long-term survival after pancreaticoduodenectomy in patients with pancreatic cancer.
      PubDate: Wed, 30 Nov 2022 00:00:00 +030
       
  • Effect of systemic isotretinoin use on neutrophil/lymphocyte ratio in acne
           patients: A retrospective study

    • Authors: Hanife Merve AKÇA
      Abstract: Objective: Acne vulgaris (AV) describes a chronic inflammatory condition that occurs in the pilosebaceous unit, which is common in the community. Increase in sebum production, abnormal follicular keratinization, Propionibacterium acnes (P.acnes) colonization and inflammation play a role in acne development. ISO, comedolytic, is the only agent that has an effect on all four conditions that determine the pathogenesis of acne, such as a large reduction in sebaceous gland size, suppression of sebum production and reduction in inflammation. In this study, it was aimed to compare the N/L ratio values at the beginning of the treatment and at the 4th month of the treatment in acne vulgaris patients receiving systemic ISO treatment. Material and Method 50 patients with acne vulgaris who applied to the dermatology outpatient clinics of Karaman Training and Research Hospital between October 2020 and February 2021, had moderate and severe acne vulgaris and were started on oral isotretinoin were included in the study. The medical records of the patients were reviewed retrospectively. The neutrophil/lymphocyte (N/L) ratio values of the patients at the beginning of Isotretinoin treatment and after four months were recorded. Results The mean age of the patients was 23.1±6.23, 52.0% (26 persons) were male. There was a significant decrease in the N/L ratio in total and in both genders with isotretinoin use (p
      PubDate: Wed, 30 Nov 2022 00:00:00 +030
       
  • A Pilot Study on the Performance of Presepsin in Acute Appendicitis: A
           Prospective Case-Control Study

    • Authors: Serçin TAŞAR; İlknur FİDANCI, İsmail BULUT, Özkan CESUR, Nihal AVCI, Gizem ÇALIK, Mehmet ŞENEŞ, Medine TAŞAR
      Abstract: Aim: Diagnostic biomarkers are needed for pediatric acute appendicitis (AA). We hypothesized that presepsin (soluble CD14 subtype), a biomarker for sepsis, can also be used in pediatric AA and aimed to investigate its diagnostic value in those patients.Materials and Methods: This prospective case-control study was conducted on children admitted to the Pediatric Emergency Department with suspected acute appendicitis. Serum levels of interleukin-6, and presepsin were statistically analyzed for their diagnostic values.Results: No remarkable demographic differences were present between the 41 cases and 47 controls. Clinical and routine laboratory findings were significantly positive for acute appendicitis in the cases compared to controls. ROC analysis indicated an AUC for presepsin as 0.999 (CI 95%: 0.890-0.993) and for interleukin-6 as 0.963 (CI 95%:0.949-1.000). The best cut-off point value for presepsin was at 739 pg/ml, corresponding to a sensitivity of 97.56% and a specificity of 100%. The best cut-off point value for interleukin-6 was at 19 pg/ml, corresponding to a sensitivity of 97.56% and a specificity of 90.32%.Conclusions: Our study results indicate that presepsin can be considered a biomarker for diagnosing appendicitis in pediatric cases. Future studies might better include the combination with other biomarkers in pediatric cases.
      PubDate: Wed, 30 Nov 2022 00:00:00 +030
       
  • Relationship Between Carpal Bone Morphology and Distal Radius Fracture
           Pattern

    • Authors: Tamer COŞKUN; Hasan ARIK, Sertaç MEYDANERİ
      Abstract: AbstractBackground: In this study, we examined whether carpal bones (lunate, hamate, capitate) morphologies and fourth metecarp-capitate articulation have an effect on the distal radius fracture pattern.Methods: 206 patients who applied to the emergency department with distal radius fracture between 2016-2020 were included in the study. Preoperative and pre-reduction x-ray films of the patients were examined. Lunate, hamate, capitate morphologies and 4.metacarp articulation analyzed and classified. Distal radius fracture types were classified according to AO and Fernandez. The relationship between carpal bone morphology and distal radius fracture type was analyzed.Results: This study consisted of 101 men and 103 women. AO fracture types and carpal bone morphologies (lunate joint type according to Viegas, lunate type according to Zapico, capitate morphology, hamate morphology and capitate-4 metacarpal joint morphology) did not differ significantly (p > 0.05). Fernandez fracture types and carpal bone morphologies (lunate joint type according to Viegas, lunate type according to Zapico, capitate morphology, hamatum morphology and capitate-4.metacarp joint morphology) were compared, there was no significant difference (p > 0.05).Conclusion: As a result, no clear relationship could be demonstrated between carpal bone morphology and distal radius fracture pattern.
      PubDate: Wed, 30 Nov 2022 00:00:00 +030
       
  • EFFECTS OF DIOSMIN ADMINISTRATION ON CISPLATIN-INDUCED PREMATURE OVARIAN
           FAILURE IN A RAT MODEL

    • Authors: Ali GÜRSOY; Ayşe Gökçen SADE
      Abstract: mWe aimed to examine the potential beneficial effects of diosmin administration on cisplatin - induced premature ovarian failure (POF) in a rat modelMaterial and MethodsTwenty-eight rats were divided into four groups. Group A rats (n:7) were determined as the sham group. The remaining rats received an intraperitoneal injection of 1.5 mg/kg/day cisplatin for 10 days to create a POF model. Then, they were randomly divided into 3 subgroups.Group B was determined as POF group. Group C rats were given 100mg/kg/day diosmin for 10 days simultaneously while creating POF model. Group D rats were given 100mg/kg/day diosmin for 10 days after POF model was created. Twentieth day blood samples were taken and left ovaries were resected for examination.ResultsCIS-induced rats showed reduced levels of SOD, AMH and E2 compared to sham group rats (p0.05) between the sham group, group C and D. No significant (p>0.05) difference in FSH value was observed between group C, D and sham groups.There was no significant (p>0.05) difference in the number of secondary and antral follicles between group C and D compared to the sham group. Primordial follicle count was significantly higher in group C than group B (p
      PubDate: Wed, 30 Nov 2022 00:00:00 +030
       
  • Is intraarticular enjections effective on pain management in patients with
           late stage primer gonarthrosis during COVID-19 pandemic' A single
           centre experience

    • Authors: Mete GEDİKBAŞ; Yusuf BAYRAM
      Abstract: Background: Primary gonarthrosis is a progressive disease that increases with age and leads to limitations in activities of daily living. Until surgery is performed, nonsteroidal anti-inflammatory drugs, intraarticular injections, and physical therapy methods are used.Purpose: This study aims to compare the clinical outcomes of intra- articular corticosteroid (CCS) and hyaluro nic acid (HA) injections for pain relief in primary gonartrhosis in COVID -19 pandemic period.Study Design: Retrospective Cohort Study.Methods: In this study, 88 patients who underwent intra-articular CCS and HA injection between August 2020 and March 2021 due to Kellgren-Lawrence stage 2 and higher gonarthrosis were investigated. Patients were divided into two groups. Group I represents the patients who received HA injections, and group II represents the patients who received CCS injection. Western Ontario and McMaster Universities Arthritis Index (WOMAC) and Knee Society Score (KSS) scores were used for the preoperative and postoperative functional evaluations of the patients. Results: Group I included 40 patients and group II included 48 patients. The mean age was 59.4 ± 7.3 years, and the average follow-up period was 12 ± 2,6 months. The pre-intervention WOMAC scores were 13,5 in Group I and 13.6 in Group II, KSS scores were 26,5 in Group I and 25,2 in Group II. While there was a significant change in the control at month 1 in both groups, no difference was found between the groups. At the 6th month control, the improvement in group 1 continued at a significant level compared to the pre-injection period, while group 2 returned to the pre-injection level. (p
      PubDate: Wed, 30 Nov 2022 00:00:00 +030
       
  • Determining the interest in pain and analgesic during and before the
           covid-19 pandemic period using google trends data: an infodemiological
           study

    • Authors: Seda GÜNDÜZ BAŞÇIL; Sevinç MEŞE
      Abstract: Background: The aim of this study is to evaluate the public's interest in pain and painkillers using Google search activity in countries with the most cases before and during the COVID-19 pandemic (January 2018 - December 2021).Methods: United States (USA), England, France, Germany, Italy, India, Spain, Russia, Brazil and Turkey, which are the countries where the Covid 19 epidemic was most intense, were determined along with the world for the analysis. The words of "Back pain", "Chest pain", "Headache", "Knee pain", "Sore throat", "Aspirin", "Ibufren" and "Paracetamol" were written into the Google Trend search engine. RapidMiner Analysis program and Microsoft Excel program were used in the statistical analysis of the data. Correlation tests were used to determine the strength of the relationship between pain regions and drugs.Results: The terms fo "ibuprofen", "aspirin", "paracetamol" peaked in Google searches on March 15, 2020. The search frequencies of the terms of sore throat, chest pain, and headache peaked worldwide between March 15, 2020 and March 22, 2020. The strong correlations were obtained, ranging from 0.627 to 0.901 for chest pain and headache terms, and 0.629 to 0.749 for ibuprofen and paracetamol terms. Conclusion: As a result of the research, it is seen that the frequency of searching for pain and analgesics has increased significantly during the COVID-19 period. Our data can be considered as an indicative of the increasing incidence of pain with the COVID-19 pandemic, since internet searches are a proxy for the public good.
      PubDate: Wed, 30 Nov 2022 00:00:00 +030
       
  • Comparison of the Effects of Different Molecular Weight Hyaluronic Acid
           Application in Knee Osteoarthritis

    • Authors: Ali ÇOŞTU
      Abstract: Objective: The objective of this study was to evaluate the effect of different molecular weight (MW) hyaluronic acid (HA) application on pain and functional parameters in knee osteoarthritis (OA).Methods: This study was designed as retrospectively. Hospital records of the patients who received intraarticular HA injection therapy in our center were screened. The patients were divided into 3 categories according to the MW of the preparates as the follows; Group 1: 0,6-1,2 Milion Da of MW (N=26); Group 2: 1,1- 2,2 Million Da of MW (N=25); and Group 3: 1,7-2,1 Million Da of MW (N=25). All patients were assessed using Visual Analogue Scale (VAS) and Western Ontario and McMaster Universities Arthritis Index (WOMAC) before the treatment and one month after the injection.Results: A total of 76 patients (61 females, 15 males) with a mean age of 62,1 years (minimum-maximum: 50-70 years) were included. VAS and WOMAC scores did improve significantly in all groups (all for p
      PubDate: Wed, 30 Nov 2022 00:00:00 +030
       
  • Prognostic value of clinicopathological characteristic of patients with
           Malign Mesothelioma at Mediternean region of Turkey

    • Authors: Erkan KAYIKÇIOĞLU; Armağan AYDIN
      Abstract: Aim: To define the effect of clinicopathological characteristics of patients with malign mesothelioma (MM) on overall survival.Materials and Methods: Forty-one patients diagnosed with MM who were treated at the medical oncology clinics between 2008 to 2020 were assessed. Clinicopathological characteristics and overall survival (OS) of patients, and treatment modalities analyzed.Results: Forty-one patients were included in this study. The median age of patients was 63.5. At a median follow-up of 16.7 (range:0.5-172.6) months, 78%(32) of patients died. Median OS was 17.6 months. 65.9% (27) of patients had stage 3 and 29.3% (12) had stage 4 diseases when they were diagnosed. Most of the patients were diagnosed at the advanced stage (Stages 3-4) (95.2%). The median OS of patients diagnosed with epithelioid histopathologic subtype was 32.4 months, while the median OS of those with sarcomatoid was 5.23 months, while the median OS of biphasic was 4.33 months. This difference was statistically significant (p
      PubDate: Wed, 30 Nov 2022 00:00:00 +030
       
  • Oxidative Stress Index and Vitamin C in The Diagnosis of Fibromyalgia
           Syndrome

    • Authors: Muzaffer KATAR; Köksal DEVECİ, Hülya DEVECİ
      Abstract: Aim: Still there is no any specific laboratory marker for diagnosis of FMS and it mainly depends on clinical examination. So that we aimed to evaluate whether serum Vitamin C levels and oxidative stress index (OSI) can be used in the diagnosis of Fibromyalgia Syndrome (FMS). Material and Method: 53 female patients and 35 healthy female controls were enrolled to our cross-sectional study. VAS, BDI and FIQ were applied to the patients. Vitamin C levels were measured by HPLC. Total Antioxidant Capacity (TAC) and Total Oxidant Status (TOS) levels were determined by Spectrophotometric Assay method.Results: While vitamin C and TAC levels of FMS patients were significantly lower than those of the controls, OSI was significantly higher in patients (p= 0.004, p= 0.009 and p= 0.048, respectively). There was a moderate positive and significant relationship between the tender points and FIQ, (r = 0.505; p
      PubDate: Wed, 30 Nov 2022 00:00:00 +030
       
  • The Burnout Levels of Caregivers and Caregiver Burden of the Patients with
           Declined Active Participation in the Community Mental Health Center During
           the Covid-19 Pandemic

    • Authors: Seda YILMAZ
      Abstract: Aim:This study aimed to compare the burnout and caregiver burden in caregivers during Covid-19 due to the decrease in patient participation in the Community Mental Health Center (CMHC) and the inability to accept patients for a while before the Covid-19 pandemic.Materials and Methods:Caregivers of 47 patients registered to CMHC were included in this study. The first interview for this study was held in January 2020, before the start of the Covid-19 pandemic in Turkey. The second interview was held in June 2021, after the start of the COVID -19 pandemic and thus lockdown and restrictions. Sociodemographic data form, Maslach Burnout Inventory, and Zarit Caregiver Burden Scale were applied to caregivers. Results:The findings obtained in the second interview showed that Maslach Burnout Inventory (p
      PubDate: Wed, 30 Nov 2022 00:00:00 +030
       
  • Evaluation of Acute Phase Reactants in Patients with Ankylosing
           Spondylitis

    • Authors: Ferhan DEMİRER AYDEMİR; Gerçek CAN, Sadettin USLU, Gökçe KENAR, Merih BİRLİK, Fatos ÖNEN
      Abstract: Objective: To determine the high levels of acute phase reactants (APR) of ankylosing spondylitis (AS) patients at diagnosis and follow-up, and to investigate the relationship between patients’ high levels of APR and patients’ disease activity levels and clinical characteristics.Material and Methods : 948 patients who were diagnosed with AS according to the modified 1984 New York criteria and followed-up at the university rheumatology clinic were included in this study. The patients’ erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) levels across all visits were retrospectively reviewed through the registry and the hospital’s database.Results: At first visit, high levels of CRP and ESR were observed in 626 (68.5%) and 578 (64.6%) patients respectively. During follow-up 84.6% of patients had high CRP and 69.5% patients had high ESR, however in 10% of patients APRs did not increase at all. There was good correlation between ESR and CRP (r=0.666, p=0.000). A better correlation was observed at first visit between CRP and BASDAI (r=0.81, p=0.23) or ASDAS (r=0.468, p=0.000) compared to ESR and BASDAI (r=0.111, p=0.02) or ASDAS (r=0.334, p=0.000). Compared to BASDAI, ASDAS with either ESR (p=0.00) or CRP (very high disease activity-p=0.000, inactive disease-p=0.001) had better performance in evaluating the activity of the patient in inactive and very high levels of severe disease.Conclusions: Our results showed, high levels of acute phase reactants is not rare in AS patients. APR should be considered the most significant laboratory diagnostics in the evaluation of AS and/or response to the treatment.
      PubDate: Wed, 30 Nov 2022 00:00:00 +030
       
  • Multisystem inflammatory syndrome in a male adolescent after his second
           Pfizer-BioNTech COVID-19 vaccine: a report from Turkey

    • Authors: Hayrullah ALP; Melih Timuçin DOĞAN
      Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), continues to spread rapidly through human populations, presenting across a continuum of severity from a symptomatic carriage to multi-organ failure and death. Multisystem inflammatory syndrome in children (MIS-C) is a new phenomenon reported worldwide with temporal association with SARS-CoV-2. Multisystem inflammatory syndrome in children is a complication of the SARS-CoV-2 infection, while myocarditis is a rare adverse effect to messenger ribonucleic acid (mRNA) SARS-CoV-2 vaccines, especially in males aged 12–17 years . On the other hand, postimmunization myocarditis is a known rare adverse event after other vaccinations, such as smallpox . Today, rare cases of MIS-C and myocarditis after mRNA SARS-CoV-2 vaccinations have been reported in children or adolescents . We present details on a 15-year-old previously healthy Turkish male adolescent who fulfilled the diagnostic criteria for MIS-C after the Pfizer-BioNTech vaccine.
      PubDate: Wed, 30 Nov 2022 00:00:00 +030
       
  • Occupational risk perception of nursing students, affecting factors and
           their association with occupational accidents: A crosssectional,
           multicenter study

    • Authors: Sevda TÜREN; Sevda EFİL, Elif BÜLBÜL, Tuğba YENİ, Meryem YILDIZ AYVAZ, Rahime ATAKOĞLU YILMAZ
      Abstract: Aim: Occupational risks by leading to accidents and diseases can adversely affect the health of nursing students and can cause serious injuries. Therefore, students are expected to be aware of these risks in order to be aware of occupational accidents or diseases and take precautions. This study was aimed to evaluate the occupational risk perception of nursing students and the factors affecting it and their association with occupational accidents.Material and Methods: Study was carried out with 728 nursing students in six universities. The data were collected using “Data Gathering Form” prepared by researchers and “Occupational Risk Perception Scale (ORPS)”. Results: The mean age was 20.8±1.65 (min.18-max.35) years and the majority (82.0%) of the participants were females. Clinical practice areas were defined as high risk areas by the 65.1% of the students. Number of the students encountered any health threatening occupational accidents in clinical practice was 223 (30.6%). ORPS score was significantly higher in women, health vocational high school graduates, students with previos occupational health and safety training and students those who encountered occupational accidents before (p
      PubDate: Wed, 30 Nov 2022 00:00:00 +030
       
  • Comparison Of Winograde And Vandenbos Surgical Techniques According To
           Heifetz Stage In The Treatment Of Ingrown Toenails

    • Authors: Emre KAYA; Tamer COŞKUN
      Abstract: AbstractBackground: In ingrown toenail, classifications and the treatment approaches according to staging has been clearly reported in the literature. However, there are not enough data about the selection of the appropriate surgical technique according to the stage. In this study, we compared two different surgical techniques in patients with Heifetz stage 2 and 3 in means of surgical results, recovery time, patient comfort and cosmetics.Methods: Between January 2019 and January 21, patients who applied with the complaint of ingrown toenails who were treated with two mentioned surgical techniques in two centers with at least 1 year follow-up were included. The patients were evaluated preoperatively in means of the Heifetz classification. In group 1 (n:54) matrix excising Winograd and in group 2 (n:51) matrix preserving Vandenbos techniques were used. Postoperative recovery time, complication rates, functional and cosmetic patient satisfaction were evaluated in tall cases. Results: 105 cases of ingrown toenails treated surgically were included in the study. 62 (59%) cases were Heifetz stage 2, 43 (41%) cases were Heifetz stage 3. No statistically significant difference was found between Heifetz stage 2 and stage 3, regardless of surgical technique, in complication, recurrence, patient functional/cosmetic satisfaction rates, and recovery time. In overall analysis regardless of Heifetz staging, recovery time was shorter with Winograd method (p:0.0001), complication and recurrence rates were lower with Vandenbos method (p:0.0001), and VAS cosmetic satisfaction was higher in Vandenbos (p:0.002).Conclusion: Winograd and Vandenbos in Heifitz stages 2 and 3 have low complication rates and high patient satisfaction. Earlier healing could be achieved with the Winograd technique, while low complication/recurrence rates and high cosmetic satisfaction could be achieved with the Vandenbos technique. Early recovery/high cosmetic expectation should be considered instead of Heifetz staging in determining the surgical technique.
      PubDate: Wed, 30 Nov 2022 00:00:00 +030
       
  • The relationship between fatigue, neuropathic pain, and neurophysiological
           features in carpal tunnel syndrome

    • Authors: Şencan BUTURAK; Halit FİDANCI, Ahmet Candan KÖYLÜOĞLU, Mehmet YILDIZ, Zülfikar ARLIER
      Abstract: Introduction: Carpal tunnel syndrome (CTS) is the most common entrapment mononeuropathy and can affect patients' daily living activities. In this study, it was aimed to find out whether there is a relationship between fatigue, neuropathic pain and neurophysiological features in CTS.Material and Method: Patients with clinical features compatible with CTS were included in this retrospective study. Median nerve compound muscle action potential (CMAP) and compound nerve action potential (CNAP) of the patients were analyzed. The Turkish version of the Fatigue Severity Scale (FSS) was administered to all patients. Patients with a mean FSS score of ≥4 were considered to have fatigue. In addition, Leeds Assessment of Neuropathic Symptoms and Signs (LANSS) was applied to some patients. If the LANSS score was 12 or higher, these patients were considered to have neuropathic pain.Results: Thirty-two female and eight male CTS patients were included in the study. Thirty-two patients had clinically bilateral CTS and eight patients had right-sided CTS. FSS and LANSS were administered to 40 and 18 patients, respectively. There were 29 CTS patients (72.5%) with an FSS score ≥ 4. CNAP/CMAP amplitudes and sensory/motor nerve conduction velocities of patients with fatigue were lower than those without fatigue (p
      PubDate: Wed, 30 Nov 2022 00:00:00 +030
       
  • Physical Activity Levels of Medical Students: a global issue to be
           addressed

    • Authors: Tuba BAYKAL; Feray SOYUPEK
      Abstract: Aim: Regular physical activity has been shown to have positive effects on general health, cognitive functions, and mental health. The vast majority of university students do not meet the physical activity recommendations of well-accepted guidelines. In this study, we aimed to determine the physical activity levels (PALs) of medical school students and the related factors.Materials and Methods: This is a cross-sectional, observational survey study. The survey was conducted with an online Google survey tool. Five hundred and twenty-eight students who approved the voluntary consent form were included in the study. A questionnaire including sociodemographic data and questions about personal lifestyle were used. The physical activity levels of the participants were determined with the International Physical Activity Questionnaire-short form (IPAQ-SF), depression and anxiety levels were determined with Beck Depression Inventory (BDI) and Beck Anxiety Inventory (BAI), respectively.Results: The mean total IPAQ-SF scores of the participants were 1658±1793.91 METs. A statistically significant negative correlation was found between BDI scores and PALs (r=-0.102, p=0.019). The PALs of those who had active hobbies and those who participated in regular sports activities were statistically significantly higher (p
      PubDate: Wed, 30 Nov 2022 00:00:00 +030
       
  • Prolonged Response with Enzalutamide in a Prostate Cancer Patient on
           Hemodialysis

    • Authors: Özge KAMA BAŞCI; Ferhat EKİNCİ, Gonca AKDERE ATEŞ, Atike Pinar ERDOĞAN, Ahmet DİRİCAN
      Abstract: Current therapies in oncology that offer a longer and better quality of life are leading to more cases where cancer and chronic diseases coexist. Enzalutamide, a second-generation anti-androgen agent, was approved by the US Food and Drug Administration (FDA) in 2012 for the treatment of metastatic castration-resistant prostate cancer (mCRPC). There is no series with many patients on the use of enzalutamide in patients with end-stage renal disease (ESRD). We present a patient diagnosed with mCRPC who was followed up with enzalutamide treatment for about 5 years after progression with docetaxel and who was on hemodialysis 3 days a week.
      PubDate: Wed, 30 Nov 2022 00:00:00 +030
       
  • An overview of the genetic diversity of Echinococcus granulosus sensu lato
           in Turkey

    • Authors: Sümeyye BAŞER; Salih MAÇİN, Gülay MAÇİN, Serra ÖRSTEN
      Abstract: Echinococcus granulosus is a parasite that lives as a host in animals and humans, causes great economic damage and poses a serious threat to health. Morphological differences and intermediate host preference are used to distinguish the species of this parasite. Ten genotypes and lion strains of Echinococcus granulosus have been identified in molecular studies to date. It contributes to the fact that the effects of cystic echinococcosis detected in humans and the disease process caused by different genotypes can be handled differently. In genetic diversity analysis, species were classified as Echinococcus granulosus sensu stricto, Echinococcus equinus, Echinococcus ortleppi, Echinococcus canadensis and Echinococcus felidis genotypes. Echinococcus granulosus sensu stricto is the most common cause of human cystic echinococcosis worldwide and in Turkey. In this review, the distribution and epidemiology of Echinococcus granulosus genotypes detected in humans and animals in Turkey are discussed.
      PubDate: Wed, 30 Nov 2022 00:00:00 +030
       
  • The Effect of Artemisinin on Oxidative Stress Markers in Mouse Heart and
           Lung Tissues in an Experimental Model of Epileptic Seizure.

    • Authors: Yılmaz KOÇAK; Zübeyir HUYUT, Fikret TÜRKAN, Oruc ALLAHVERDİYEV, Bahattin BULDUK, Ugur OZDEK
      Abstract: Aim: The current study investigated the effects of artemisinin on the heart and lung tissue against pentylenetetrazol-induced seizures in mice. For this purpose, malondialdehyde (MDA), advanced oxidation protein products (AOPP), Catalase (CAT), glutathione (GSH), and glutathione peroxidase (GSH-Px) levels were evaluated in both tissue homogenates.Material and Method: Swiss albino male mice (n=42) were used in the experiment. Animals were divided into six groups; Control (C), pentylenetetrazol (PTZ), valproate 100 mg/kg (VPA), artemisinin 30 mg/kg (ARS)+PTZ, ARS 60 mg/kg+PTZ, ARS 120 mg/kg+PTZ. On the 26th day of the experiment, the mice were sacrificed and the samples were kept at -80 0C for biochemical analysis.Results: There were significant differences in the five biochemical parameters analyzed in heart and lung tissues. Heart and lung MDA levels of the PTZ group were found to be significantly higher than the C and ARS-60 groups (p<0.05). Heart and lung MDA levels of the PTZ group were found to be significantly higher than the C and ARS-60 groups. Likewise, heart AOPP levels decreased significantly in the VPA and ARS-60 groups compared to the PTZ group (p<0.05). There was no significant difference between the groups in terms of lung AOPP levels (p>0.05). Heart CAT and GSH levels were decreased in the PTZ group compared to the other groups. However, in terms of Lung CAT levels, the PTZ group had the highest value compared to the other groups, while it had the lowest value in terms of GSH level. The GSH-Px level did not differ significantly between the groups in heart tissue (p>0.05). The lung GSH-Px level was significantly increased in the ARS-30 group when compared to the PTZ group (p<0.05).Conclusion: Consequently ARS treatment can inhibit PTZ-induced oxidative stress in peripheral tissues. In addition, ARS may provide improvements in decreased antioxidant enzymes. ARS may contribute to the antioxidant defense system.
      PubDate: Wed, 30 Nov 2022 00:00:00 +030
       
  • Comparison of Laparoscopy and Laparotomy Results for Benign Ovarian Tumors

    • Authors: Jule ERİÇ HORASANLI; Gülnur EREN, Mehmet Sinan İYİSOY
      Abstract: AbstractObjectives: To present the data generated at our hospital by comparing the operative characteristics and surgical results of patients who applied to the clinic and emergency room due to ovarian cyst and underwent laparoscopy or laparotomy.Materials and Methods: In this retrospective study, patients who underwent cystectomy, oophorectomy, and hysterectomy salpingo-oophorectomy due to ovarian cysts were compared in two groups, comprising laparoscopy and laparotomy. Evaluated retrospectively in this study were 443 patients operated on due to benign ovarian cyst diagnosis. Data in the patient files were analyzed in terms of age, cyst size, postoperative hemoglobin, postoperative white blood cell count, operating time, hospital stay, and surgical site infection.Results: Postoperative surgical site infection was significantly higher in the laparotomy group. The risk of surgical site infection was RR= 4. 5 (1.74–11.67) times higher in those who underwent laparotomy when compared to laparoscopy. The duration of hospital stay was lower in the laparoscopy group for all operation types (oophorectomy, cystectomy, and hysterectomy salpingo-oophorectomy). The cyst sizes of the patients who underwent hysterectomy salpingo-oophorectomy were significantly more significant in the laparotomy group. The duration of hospital stay in the patients who underwent hysterectomy salpingo-oophorectomy was significantly longer when compared to the laparoscopy group, while no significant difference was found in the oophorectomy and cystectomy patients. The need for blood transfusion was significantly lower in the laparoscopy group for all operation types.Conclusions: It was concluded that the duration of hospital stay, surgical site infection, need for blood transfusion, and operating time was less in patients who underwent laparoscopy. Laparoscopic surgery methods can be safely recommended for rapid and effective treatment of benign ovarian cysts with cystectomy, oophorectomy, and laparoscopic hysterectomy about hospital stay and complications.
      PubDate: Wed, 30 Nov 2022 00:00:00 +030
       
  • Estrogen in Luteal Phase Support: Effects on IVF-ICSI Antagonist Protocol
           Pregnancy Results

    • Authors: Cemre ALAN; Hüseyin GÖRKEMLİ
      Abstract: Aim: This study aimed to investigate the effect of luteal phase support (LPS) with estradiol in addition to progesterone on pregnancy outcomes in patients who underwent ovulation induction with GnRH antagonist protocol in in vitro fertilization- intracytoplasmic sperm injection (IVF-ICSI).Materials and Methods: This retrospective study was carried out at reproductive medicine center of Necmettin Erbakan University Meram Medical Faculty. The study enrolled 128 patients undergoing ICSI on an antagonist protocol for controlled ovarian hyperstimulation. Study group administered 7.8 mg transdermal estradiol (E2) daily in addition to progesterone for LPS (n=64). Control group administered only progesterone for LPS (n=64). All women received 200 mg progesterone 3x1 intravaginal daily and 50 mg progesterone intramuscular injection per two days for LPS. Blood samples were drawn 12 days after embryo transfer for β-hCG. If the result is negative, treatment was discontinued, if positive, estradiol was discontinued and progesterone support was continued until the 10th week of gestation. Pregnancy outcomes were the main endpoint.Results: There was no difference between groups in terms of biochemical pregnancy, clinical pregnancy, abortus and ongoing pregnancy rates.Conclusion: In our study, the use of estrogen for luteal phase support in GnRH antagonist protocol did not show any difference on pregnancy outcomes.
      PubDate: Wed, 30 Nov 2022 00:00:00 +030
       
  • Common ECG Changes and Prognostic Importance of ECG Findings in Covid-19
           Patients Presenting to the Emergency Department

    • Authors: Mehmet Göktuğ EFGAN; Osman Sezer ÇINAROĞLU, Umut PAYZA, Efe KANTER, Büşra Dilara CEBECİ
      Abstract: Aim: It is known that cardiac involvement may occur in patients with COVID-19 infection. And one of the best diagnostic tools of cardiac involvement is the ECG. The aim of this study is to investigate the common ECG findings in COVID-19 infection and the effect of these findings on the prognosis.Material and Method:215 patients who applied to our emergency department between 04.06.2022 and 04.08.2022 and met the criteria for inclusion in the study were included in this study. All patient results and ECG images were accessed from the hospital data recording system. The results were used for statistical analysis.Results:Of 215 patients, 118 were female and 97 were male, and the mean age was 58±21 years. Of these patients, 52 were hospitalized in the service and 17 were hospitalized in intensive care units, and 146 patients were discharged from the emergency department. The most common ECG finding was ST-T wave change. It was observed that there was a correlation between the detection of VT in the ECG and the intensive care unit admission. It was observed that the ECG findings of the patients had no effect on the prognosis.Conclusion: All ECG findings can be seen in patients admitted to the emergency department with COVID-19 infection. The most common ECG finding is ST-T wave change. In addition, long QTc, sinus tachycardia and AF are also common. However, no correlation was found between ECG findings and disease prognosis.
      PubDate: Wed, 30 Nov 2022 00:00:00 +030
       
  • SEROPREVALENCE OF HBsAg, Anti-HBs, Anti-HCV, and Anti-HIV IN PATIENTS WITH
           ALCOHOL AND SUBSTANCE ABUSE IN AN AMATEM CLINIC IN EASTERN TURKIYE: A
           SIX-YEAR RETROSPECTIVE EVALUATION

    • Authors: Pinar ÖNER; Seda YILMAZ, Nülüfer KILIÇ, Filiz ÖZSOY
      Abstract: AimSubstance abuse and concomitant infections are important causes of morbidity and mortality. Yet, the number of epidemiological studies regarding infectious diseases in people with substance abuse are limited in our country. In this study, the aim was to investigate the frequency of illegal alcohol and substance use in an Alcohol and Drug Research, Treatment and Training Centres (AMATEM) clinic in Turkey as well as the HBsAg, anti-HBs, anti-HCV, and anti-HIV parameters between the years of 2016-2021. Material and MethodHBsAg, anti-HBs, anti-HCV, and anti-HIV tests were conducted using the ELISA technique in 6881 alcohol and substance use disorder (ASUD). Urine samples from ASUD’s were analyzed for alcohol, cannabis, and cocaine metabolites. The results were evaluated retrospectively. ResultsAll of the 6881 ASUD’s were male with a mean age of 32.18±9.66 years. Of the 6881 ASUD’s included in the study, 4107 (59.7%) were opioid addicts; 1479 (21.5%) were mixed drug addicts; 897 (13%) were alcohol addicts; and the rest were addicts with other types of substance use. The mean age of the alcohol users was 45.33±13.03 and the mean age of opioid users was 29.90±7.13. The percentage of opioid addiction in 2016 was 71.2% which dropped to 28.7% in 2021. Meanwhile, the percentage of alcohol addiction was 13.6% in 2016 and increased to 21.4% in 2021; and the percentage of mixed drug use was 8.7% in 2016 and increased to 36.8% in 2021. HBsAg-positivity in opioid users (56.7%) was higher compared to cannabis users (2.6%) and mixed drug users (22.3%). Anti-HCV positivity of opioid users (69.4%) was found to be higher compared to alcohol (9.4%), cannabis (2%), and mixed drug (16.2%) users, and this finding was statistically significant (p=0.0001). Anti-HBs positivity of opioid users (63.1%) was found to be higher compared to alcohol (9.9%), cannabis (3%), and mixed drug (21%) users, and this finding was statistically significant (p=0.0001). Anti-HIV was determined negative in all ASUD’s. The highest rates of HBsAg, anti-HCV and anti-HBs positivity were found in the 26-30 years of age. ConclusionThese findings indicate a high prevalence of intravenous substance abuse in the 26-30 years age group in our region as well as the high HBV and HCV rates in this patient group.
      PubDate: Wed, 30 Nov 2022 00:00:00 +030
       
  • Effects of Carbohydrate and Fats in Turkish Patients with Type 2 Diabetes

    • Authors: M. Gizem KESER; Hülya HACİŞAHİNOĞULLARI, Kubilay KARŞIDAĞ, Hüsamettin VATANSEV, Suleyman IPEKCİ, Hafize YAĞCILAR TAN
      Abstract: Aim: This study aimed to assess the effects of different kinds of diet, which were similar in total energy density but different in carbohydrate and fats, on some blood parameters in type 2 diabetics. Materials and Methods: In this study, 33 type 2 diabetics, participants were offered two different kinds of lunches within 7 days intervals. Venous blood samples were collected from the participants half an hour before and after the consumption of these meals (0-180 minutes). Blood parameters such as glucose, insulin, low-density lipoprotein (LDL-C), high-density lipoprotein (HDL-C), and triglyceride were analyzed through blood samples.Results: There was no significance between the values of the change in blood glucose before and after their consumption of the standard meal and etli ekmek. After the consumption of the etli ekmek difference between the participants’ mean insulin level values at 60 and 90 minutes was lower than the standard meal. The values under the curve (AUC) were found to be significant (p
      PubDate: Wed, 30 Nov 2022 00:00:00 +030
       
  • Retrospective evaluation of liver transaminase abnormalities in
           asymptomatic and symptomatic patients according to liver biopsy results

    • Authors: Bahri ABAYLI; Cansu ABAYLI, Genco GENCDAL
      Abstract: Background and Aim: Histopathological examination of liver tissue is often performed with percutaneous liver biopsy. In this study, we aimed to evaluate the causes and results of liver biopsy performed for various reasons in our clinic between years 2016 and 2019.Materials and Methods: 554 of 750 liver biopsies performed between July 2016 and January 2019 were included in the study. Pathology results of liver biopsies, the clinical information of the same patients were obtained from the patient files. Biopsy indications and results of the patients were evaluated retrospectively.Results: 554 liver biopsy results (M:323, 58.4%; mean age: 45±14.3) were included in the study. The most common liver biopsy indication in our hospital, was determined as the biopsies of patients with chronic hepatitis B. This indication was followed by liver biopsies performed to examine non-viral liver enzyme elevations.The pathology results were listed as; chronic hepatitis B (65%), NAFLD/NASH (16%), AIH (3%), Hepatitis C (3%) respectively.Discussion: The diversity in liver biopsy results shows the importance of histopathological evaluation. In order to reach healthy data, multi-centered prospective randomized controlled studies with larger populations are needed.
      PubDate: Wed, 30 Nov 2022 00:00:00 +030
       
  • Posttraumatic Stress Disorder Symptoms and Related Factors in Women with
           Early Pregnancy Loss

    • Authors: Neslihan SAYIN; Şükran ERTEKİN PINAR
      Abstract: Aim: Women may experience emotions such as fear, anxiety, stress, anger or guilt after pregnancy loss, and it can lead to posttraumatic stress disorder if the women cannot cope with these emotions. This study aimed to identify posttraumatic stress disorder symptoms and related factors in women with early pregnancy loss. Material and Methods: The sample of this descriptive study consisted of 132 women hospitalised with early pregnancy loss in an Obstetrics and Gynecology service of a state hospital (
      PubDate: Wed, 30 Nov 2022 00:00:00 +030
       
  • Retrospective Analysis of Oral and Maxillofacial Pathologies

    • Authors: Emre HAYLAZ; Çiğdem ŞEKER, Gediz GEDUK, Murat İÇEN, Elif Aslı GÜLŞEN
      Abstract: Objectives: The aim of this study is to analyze the biopsy results of oral and maxillofacial lesions and to discuss them in the accompanied by the literature.Material and Method: In the study, biopsy results of 644 patients who were admitted to Zonguldak Bülent Ecevit University Faculty of Dentistry, Department of Oral and Maxillofacial Radiology between 2016-2021 for various reasons and subsequently diagnosed with oral and maxillofacial pathology were retrospectively analyzed using digital archives. Age, gender, location of the lesions and pathological diagnoses of the patients were recorded.Results: In the study, 344 (53,41%) of the patients whose biopsy reports were examined were male and 300 (46,59%) were female, and the male: female (M: F) ratio was determined to be 1,15:1. The age range varied between 7 and 88 years and the mean age was 37,85±17,35 years. Out of a total of 644 lesions, 436 (67,8%) were cysts, 148 (23,1%) were inflammatory/reactive lesions, 57 (9,3%) were benign tumors and tumor-like lesions, and 3 (0,5%) were included in the malignant tumor and tumor-like lesion group.Conclusions: The analysis of data on oral and maxillofacial lesions is of great importance for the planning of preventive and therapeutic services.Amaç: Bu çalışmanın amacı, oral ve maksillofasiyal lezyonların biyopsi sonuçlarını analiz etmek ve literatür eşliğinde tartışmaktır.Gereç ve Yöntem: Çalışmada, 2016-2021 yılları arasında Zonguldak Bülent Ecevit Üniversitesi Diş Hekimliği Fakültesi Ağız, Diş ve Çene Radyolojisi Anabilim Dalı'na çeşitli nedenlerle başvuran ve sonrasında oral ve maksillofasiyal patoloji tanısı alan 644 hastanın biyopsi sonuçları dijital arşiv kullanılarak retrospektif olarak incelenmiştir. Hastaların yaşları, cinsiyetleri, lezyonların lokalizsyonları ve patolojik tanıları kaydedildi.Bulgular: Çalışmada, biyopsi raporu incelenen hastaların 344'ü (%53,41) erkek, 300'ü (%46,59) kadın olup, erkek:kadın (E:K) oranı 1,15 :bir olarak belirlendi. Yaş aralığı 7 ile 88 arasında değişmekte olup, yaş ortalaması 37,85±17,35 yıl idi. Toplam 644 lezyonun 436'sı (%67,8) kist, 148'i (%23,1) inflamatuar/reaktif lezyonlar, 57'si (%9,3) iyi huylu tümörler ve tümör benzeri lezyonlardı ve geriye kalan 3 (% 0,5) patoloji malign tümör ve tümör benzeri lezyon grubundaydı.Sonuç: Oral ve maksillofasiyal lezyonlara ilişkin verilerin analizi, koruyucu ve tedavi edici hizmetlerin planlanması için büyük önem taşımaktadır.
      PubDate: Wed, 30 Nov 2022 00:00:00 +030
       
  • Barriers associated with seasonal influenza vaccination uptake among
           nurses: A cross-sectional study

    • Authors: Melike YALÇIN GÜRSOY; Furkan SAĞTAŞ
      Abstract: Aim: The aim of this study is to evaluate the barriers associated with seasonal influenza vaccination uptake among nurses Material and Method: This web-based survey conducted in Turkey, from November to December 2021. A cross-sectional study included 390 nurses. The data were collected online by the researchers through a survey form that prepared in line with the literature. Descriptive statistics and chi-square analysis were used to evaluate the data (p
      PubDate: Wed, 30 Nov 2022 00:00:00 +030
       
  • Double Blood Culture Policy Is More Effective Than Single In Neonatal
           Intensive Units

    • Authors: Murat KONAK; Muhammed Yaşar KILINÇ, İbrahim DİKMEN, Saime Sündüs UYGUN, Hatice TÜRK DAĞI, Hanifi SOYLU
      Abstract: Aim: Blood culture (BC) sampling and antibiotic administration are common practices in Neonatal Intensive Care Units(NICUs). However, false positive BC results might affect clinician’s decision and lead to inappropriate antibiotic treatments. The aim of this study was to investigate the effect of double culture on clinical application.Material and Methods: The study was conducted retrospectively. The blood culture results of the patients admitted to the NICU between 2016-2019 were analyzed. Considering sepsis before 2017, we took only one sample from the patient. After this period, we started to take double blood cultures. Time frames of BCs were investigated to two groups as early and late onset sepsis fistly, and then subgroups as; a-) Group 1, BCs in the first 24 hours, b-)Group 2, between 24 to 72 hours, and c-)Group 3, after 72 hours. Results: Total of 1747 BC samples were taken in study. Majority of BCs were in Group 3(62%). Male/female ratio was 1.3:1. Staphylococcus Epidermidis(S. Epi) was major source for the contamination. But, by taking dBCs, we were able to eliminate most S.Epi contamination in Group 2 (11%vs.3%) and in Group 3(41%to14%). We were able to identify some resistant Gr(-) pathogens in one arm although the other arm was negative, by taking dBC.Conclusions: Our study indicates that dBC policy in NICUs could help to clinicians for judicious decision in antibiotic use and decrease unnecessary antibiotic exposure of infants. Also it could be enable to detect some highly pathogen microorganism easily.Key words: Newborn, Septicemia, Blood culture, Coagulase Negative Staphylococci, contamination
      PubDate: Wed, 30 Nov 2022 00:00:00 +030
       
  • Evaluation of clinical features, treatment approaches and treatment
           outcomes of children with non-Hodgkin lymphoma

    • Authors: Buket KARA; Serdar UĞRAŞ, Kübra ERTAN, Yavuz KÖKSAL
      Abstract: Aim: To evaluate the demographic and clinical characteristics, treatment approaches and outcomes of our pediatric patients with non-Hodgkin lymphoma diagnosed and treated in our center.Material and Methods: Between 2006 and 2002, the oncologic charts of the patients diagnosed and followed up as non-Hodgkin lymphoma were reviewed retrospectively.Results: Eighty children with non-Hodgkin lymphoma were included in this study. There were 55 boys (68.8%) and 25 girls (31.2%). The patients’ ages ranged from 2 to 18 years (median: 11.1 years). Nine patients (11.3%) had primary immunodeficiency. Sixty-three of the patients were stage III (78.7%). The majority pathologic subtype was Burkitt lymphoma (n: 31, 38.8%). The overall survival and event-free survival rates were 71.7% and 71.5%, respectively. The patients’ overall survival rates without and with primary immunodeficiency was 81.1% and 11.1%, respectively. There was a significant difference between these two groups. Cox regression analysis showed that advanced stage and concomitant primary immunodeficiency have been risk factors for prognosis. Conclusion: Intensive treatment approaches have increased overall survival rates in children with non-Hodgkin lymphoma. However, this success rate cannot be achieved in non-Hodgkin lymphoma children with primary immunodeficiency.
      PubDate: Wed, 30 Nov 2022 00:00:00 +030
       
 
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