Publisher: Elmer Press   (Total: 12 journals)   [Sort by number of followers]

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Cardiology Research     Open Access   (Followers: 15, SJR: 0.112, CiteScore: 0)
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Intl. J. of Clinical Pediatrics     Open Access   (Followers: 5)
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World J. of Nephrology and Urology     Open Access   (Followers: 15)
World J. of Oncology     Open Access   (Followers: 1, SJR: 0.122, CiteScore: 0)
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Journal of Neurology Research
Number of Followers: 6  

  This is an Open Access Journal Open Access journal
ISSN (Print) 1923-2845 - ISSN (Online) 1923-2853
Published by Elmer Press Homepage  [12 journals]
  • Endovascular Reconstruction Utilizing Flow Diversion Stenting in a Patient
           With Bilateral Giant Cavernous Internal Carotid Artery Aneurysms

    • Authors: Keithan Sivakumar, Jaspreet Johal, Hussam Yacoub, Megan C. Leary
      Abstract: Bilateral giant cerebral aneurysms are exceedingly rare. Giant aneurysms of the internal carotid artery (ICA) carry a poor prognosis if untreated. Flow diversion is an endovascular technique whereby a device is placed in the parent blood vessel to divert blood flow away from the aneurysm and is an available treatment for giant aneurysms. A 69-year-old woman presented with progressive diplopia and was found to have bilateral ICA aneurysms. She had stenting of the left ICA aneurysm with improvement of her symptoms and no complications. Five years post procedure, she presented with recurrent diplopia and was found to have enlargement of the previously seen right-sided cavernous ICA aneurysm, which was treated with another flow diversion stent with no complications. Endoluminal reconstruction/flow diversion with Pipeline™ Embolization Device (PED) has emerged as an alternative to traditional endosaccular coiling and parent artery occlusion. We report a case of bilateral cavernous carotid giant aneurysms treated with flow diversion and demonstrate that flow diversion stenting using the PED is a safe and reliable treatment for bilateral giant ICA aneurysms. We encourage interventionists to consider this technique in patients with giant intracranial aneurysms.



      J Neurol Res. 2020;10(4):136-139
      doi: https://doi.org/10.14740/jnr593
      PubDate: 2020-07-01
      Issue No: Vol. 10 (2020)
       
  • Recombinant Tissue Plasminogen Activator Use in an Acute Stroke Patient
           With Tuberous Sclerosis

    • Authors: Reza Bavarsad Sahripour, Ana Hossein Zadeh Maleki, Balaji Krishnaiah, Andrei Alexandrov
      Abstract: Tuberous sclerosis (TS) is an autosomal dominant disease known for over a century and recognized by characteristic hamartomatous lesions involving any organ. In this report, we are presenting a patient with TS who presented with acute embolic stroke and received tissue plasminogen activator (tPA) and had a mechanical thrombectomy (MT). She had a dramatic response without any hemorrhagic complications. She is a 68-year-old Caucasian woman with the past medical history of TS since childhood who presented to the hospital with symptoms of left middle cerebral artery (MCA) syndrome (right-sided weakness, sensory loss, right facial droop, aphasia, hemianopia, and dysarthria). National Institute of Health Stroke Scale (NIHSS) score was 19. Head computed tomography (CT) was negative for any acute abnormality except cortical tubers, subependymal ventricular calcification. CT angiography of the head and neck showed proximal occlusion of the left internal carotid artery. After ruling out all exclusion criteria, the patient received tPA and had an MT with complete reperfusion (thrombolysis in cerebral infarction (TICI) 3). Brain magnetic resonance imaging (MRI) showed an acute stroke in the multivessel territories (bilateral parietal cortices, the left lentiform nucleus, medial left temporal lobe, left thalamus, and right occipital lobe) suggestive of an embolic phenomenon and did not show any hemorrhagic complication. TS patients are at increased risk of intracerebral hemorrhage either in the setting of vascular malformation or due to hemorrhage into the subependymal giant cell astrocytoma. The best explanation for the latter could be secondary to elevated venous pressure from increased intracranial pressure. Fortunately, our TS patient who presented with acute ischemic stroke was within the window and received tPA and MT. The patient not only did not have any hemorrhagic side effects afterward but also had a significant improvement in her neurologic symptoms. To our best knowledge, this is the only case report of tPA administration in a TS patient. Moreover, we need more case reports to evaluate the safety of tPA in these patients.



      J Neurol Res. 2020;10(4):140-143
      doi: https://doi.org/10.14740/jnr595
      PubDate: 2020-07-01
      Issue No: Vol. 10 (2020)
       
  • Thrombolytic Therapy for Stroke: Intravenous Tenecteplase Era

    • Authors: Mohammad Abdoli, Pegah Mohammadi, Ashkan Mowla
      Abstract: N/A




      J Neurol Res. 2020;10(4):105-106
      doi: https://doi.org/10.14740/jnr604
      PubDate: 2020-06-29
      Issue No: Vol. 10 (2020)
       
  • SARS-CoV-2 and Nervous System - Neurological Manifestations in Patients
           With COVID-19: A Systematic Review

    • Authors: Luiz Severo Bem Junior, Pedro Lukas do Rego Aquino, Nicollas Nunes Rabelo, Maria Amellia do Rego Aquino, Ana Cristina Veiga Silva, Rita de Cassia Ferreira Valenca Mota, Hildo Rocha Cirne de Azevedo Filho
      Abstract: Coronavirus (CoV) is a virus infectious disease with a considerable spectrum of clinical presentations. Symptoms ranged from asymptomatic infection to severe pneumonia that may lead to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and several clinical complications. Neurologic symptoms related to CoV have been described recently in the literature. The relationship between SARS-CoV-2 and the central nervous system (CNS) is still not clear. This review aimed to reveal the current knowledge regarding CNS manifestation in SARS-CoV-2. A systematic literature review was carried out to identify the particularities of coronavirus disease 2019 (COVID-19) in patients with CNS involvement, using the PubMed database between January 1, 2020 and April 30, 2020. Conference papers, reviews, published letters, editorials, studies in pregnant women and children, and studies only reporting on a specific factor were excluded. An initial search included as many as 83 articles. Out of the 83 screened articles, 32 were selected for full-text review. Sixteen studies were excluded because they did not analyze nervous system involvement in SARS-CoV-2 infection. Thus, 16 papers were included in this review. There were three retrospective studies and 13 case reports/series of cases. Data from the current literature reveal that patients who suffer from a severe illness have more CNS involvement, neurological symptoms (i.e., dizziness, headache) and an association with strokes. The severe patients had higher D-dimer and C-reactive protein levels than non-severe patients and presented multiple organ involvement, such as serious liver, kidney and muscle damage.



      J Neurol Res. 2020;10(4):113-121
      doi: https://doi.org/10.14740/jnr602
      PubDate: 2020-06-29
      Issue No: Vol. 10 (2020)
       
  • The Neurologic Manifestations of Coronavirus Disease 2019

    • Authors: Amjad Elmashala, Saurav Chopra, Aayushi Garg
      Abstract: The coronavirus disease 2019 (COVID-19) is an ongoing global pandemic that has so far affected 216 countries and more than 5 million individuals worldwide. The infection is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). While pulmonary manifestations are the most common, neurological features are increasingly being recognized as common manifestations of the COVID-19, especially in the cases of severe infection. These include acute cerebrovascular disease, encephalitis, and Guillain-Barre syndrome (GBS). Here, we review the neuropathogenesis of SARS-CoV-2 and the central and peripheral nervous system manifestations of COVID-19.



      J Neurol Res. 2020;10(4):107-112
      doi: https://doi.org/10.14740/jnr603
      PubDate: 2020-06-23
      Issue No: Vol. 10 (2020)
       
  • Cannabidiol and Non-Steroidal Anti-Inflammatory Drug Interactions: A Case
           of Drug-Induced Aseptic Meningitis

    • Authors: Mallory Emig, Jafar Kafaie, Samantha Ong, Xujia Li
      Abstract: Cannabidiol (CBD) and other marijuana derivatives are being more widely used in the medical community by people in an attempt to alleviate a variety of symptoms. While these products have shown promise in their analgesic properties, little is known about the potential pharmacological interactions of these and other drugs. We present a case of a 57-year-old Caucasian woman who presented with altered mental status, ataxia, left-sided numbness, and slurred speech. An extensive workup was completed and found to be largely unremarkable, though a thorough history revealed that her symptoms were likely caused by concurrent use of CBD and non-steroidal anti-inflammatory drugs (NSAIDs) resulting in drug-induced aseptic meningitis. The benign nature of CBD makes it a promising avenue for pain relief. Physicians and patients should be informed about the potential drug-drug interactions of CBD and other medications.



      J Neurol Res. 2020;10(4):132-135
      doi: https://doi.org/10.14740/jnr598
      PubDate: 2020-06-19
      Issue No: Vol. 10 (2020)
       
  • Seizures With Major Comorbidity and Complications: Association of the
           Teaching Status of the Hospitals With the Outcomes

    • Authors: Aparna Yarram, Ali Seifi, Vahid Eslami
      Abstract: Background: This study aims to compare the outcomes of complicated seizure cases in teaching institutions as compared to non-teaching hospitals.Methods: A retrospective cohort study was conducted utilizing the Healthcare Cost and Utilization Project (HCUP) national database to analyze outcomes of seizures between 2012 and 2016 in the USA.Results: We evaluated 267,430 of seizure patients with major complication or comorbidity between 2012 and 2016. Of these, 6,980 in-hospital deaths were reported. There was a trend toward a significantly higher mortality in teaching compared with non-teaching hospitals (P = 0.07). The average length of stay (LOS) was 5.2 days, with LOS in 2014 and 2016, being longer in teaching hospitals (P < 0.05). Hospital charges were not significantly different among the two groups, but both types of hospitals did show a statistically significant charge increase from 2012 to 2016 (P < 0.001).Conclusions: Our data showed that there is a trend toward significantly higher mortality in teaching hospitals. LOS was also more reported in teaching hospitals, which could be inherent to the increased volume and coordination of care and more complexity of the cases in teaching hospitals. However, hospital charges were not different in teaching versus non-teaching hospitals.



      J Neurol Res. 2020;10(4):127-131
      doi: https://doi.org/10.14740/jnr588
      PubDate: 2020-06-17
      Issue No: Vol. 10 (2020)
       
  • Neurosurgical Economic and Readmission Trends After Extracranial
           Ventricular Shunts in the United States From 2009 to 2013

    • Authors: Ross-Jordon S. Elliott, Marwah A. Elsehety, Ali Seifi
      Abstract: Background: The aim of the study was to define the association between federal payer insurance and neurosurgical economic trends and readmissions after extracranial ventricular shunts (EVS) procedures and investigate these trends from 2009 to 2013 in the United States. Methods: We identified the procedure of insertion, replacement, or removal of EVS by applying the International Classification of Disease, Ninth Edition, Clinical Modification (ICD-9-CM) Procedure Codes of 231-235, 239, 242 and 243. Data were extracted for years 2009 to 2013. Year-wise distributions of index stays, readmission, percent readmission, cost for index stays and cost for readmissions for patients requiring EVS procedures who possess Medicare insurance (ME-patients) and Medicaid insurance (MD-patients) were described. Z-test statistic was used to compare the two groups. Results: During the 5 years of study, we recorded 149,220 index stays and 29,655 readmissions within 30 days involving the procedures of insertion, replacement, or removal of an EVS. Throughout the study period, hospital readmissions involving patients requiring procedures involving EVS consistently demonstrated both the highest annual mean cost for readmissions and the highest percentage of patient readmissions in regard to all neurosurgical procedures. The differences between the annual index stays and readmissions for ME-patients versus MD-patients requiring EVS were extremely statistically significant throughout the entire study period (P < 0.0001, P < 0.0001). The mean cost of readmissions within 30 days for all patients varied significantly from $19,005 to $23,499, with an average cost of $21,279 for readmissions occurring annually during the study period (P = 0.0161). The differences between the mean cost for index stays and readmissions for ME-patients versus MD-patients requiring EVS were extremely statistically significant throughout the entire study period (P < 0.0001, P < 0.0001). Conclusions: Federal payer insurance has a significant association with neurosurgical economic and patient readmission trends after EVS procedures in hospitals in the US. Further study is needed to investigate the etiology of these differences between patients’ payer insurance and their impact on clinical outcomes after EVS procedures.



      J Neurol Res. 2020;10(4):122-126
      doi: https://doi.org/10.14740/jnr600
      PubDate: 2020-06-03
      Issue No: Vol. 10 (2020)
       
  • Rate, Clinical Features, Safety Profile and Outcome of Intravenous
           Thrombolysis for Acute Ischemic Stroke in Patients With Negative Brain
           Imaging

    • Authors: Ashkan Mowla, Haris Kamal, Sandhya Mehla, Peyman Shirani, Robert N. Sawyer
      Abstract: N/A




      J Neurol Res. 2020;10(4):144-145
      doi: https://doi.org/10.14740/jnr599

      PubDate: 2020-06-03
      Issue No: Vol. 10 (2020)
       
 
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