Publisher: Mattioli 1885 srl (Total: 9 journals)   [Sort alphabetically]

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European J. of Oncology and Environmental Health     Open Access   (Followers: 8, SJR: 0.112, CiteScore: 0)
Progress in Nutrition     Open Access   (Followers: 2, SJR: 0.193, CiteScore: 0)
Acta Bio Medica     Open Access   (Followers: 1, SJR: 0.224, CiteScore: 1)
La Medicina del Lavoro     Partially Free   (Followers: 1, SJR: 0.299, CiteScore: 1)
Sarcoidosis Vasculitis and Diffuse Lung Diseases     Open Access   (Followers: 1, SJR: 0.765, CiteScore: 2)
Dermatology Practical & Conceptual     Open Access  
Confinia Cephalalgica et Neurologica     Open Access  
Medicina Historica     Open Access  
Mediterranean J. of Hematology and Infectious Diseases     Open Access   (SJR: 0.506, CiteScore: 1)
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Dermatology Practical & Conceptual
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ISSN (Online) 2160-9381
Published by Mattioli 1885 srl Homepage  [9 journals]
  • Cutaneous spitzoid melanoma in childhood after acute lymphocytic leukemia

    • Authors: Beatriz Ferreira do Prado Bassetti; Sergio Albertini Daiuto, Gilles Landman, Francisco Macedo Paschoal
      PubDate: Thu, 28 Jul 2022 00:00:00 +000
  • Unusual Presentation of Kaposi Sarcoma During Adalimumab Therapy: A Case

    • Authors: Gulsun-Hazan Tabak; Basak Yalici-Armagan, Burkay-Adem Sahin, Ozay Gokoz, Sedat Kiraz
      PubDate: Thu, 28 Jul 2022 00:00:00 +000
  • Eccrine porocarcinoma arising from an eccrine poroma: case report

    • Authors: Ingrid Silveira; Gabriela Siliprandi Lorenz Sartori, Andre da Silva Cartell, Thaís Corsetti Grazziotin
      PubDate: Thu, 28 Jul 2022 00:00:00 +000
  • Is a triggering role or a causative role of PD-1/PDL-1 inhibitors in the
           development of paraneoplastic dermatomyositis'

    • Authors: Michela Starace; Francesca Pampaloni, Miriam Anna Carpanese, Andrea Sechi, Francesca Bruni, Aurora Alessandrini
      PubDate: Thu, 28 Jul 2022 00:00:00 +000
  • Dermoscopic View of Papular Acantholytic Dyskeratosis (PAD) of the
           Genitocrural Region

    • Authors: Dua Cebeci; Ilkay Can, Ibrahim Kobat
      PubDate: Thu, 28 Jul 2022 00:00:00 +000
  • Butterfly sign in scabies: towards an evolutionary process'

    • Authors: Teresa Oranges; Fausto Andrea Pedaci, Cesare Filippeschi
      PubDate: Thu, 28 Jul 2022 00:00:00 +000
  • Dermoscopy of pseudoepitheliomatous hyperplasia tattoo reaction pattern: A
           potential mimicker of squamous cell carcinoma

    • Authors: Biswanath Behera; Rashmi Kumari, Debasis Gochhait, Pavithra Ayyanar
      PubDate: Thu, 28 Jul 2022 00:00:00 +000
  • Dermoscopy performs an important role to diagnose radiation-induced
           angiosarcoma on the breast

    • Authors: Gabriel Tagata Seleri; Marina Riedi Guilherme, Ana Lúcia de Oliveira Prestes, Cássio Rafael Moreira
      PubDate: Thu, 28 Jul 2022 00:00:00 +000
  • A case of adult-onset facial cutaneous mastocytoma: clinical and
           dermoscopic findings

    • Authors: Matteo Megna; Massimiliano Scalvenzi, Sonia Sofía Ocampo Garza, Gabriella Fabbrocini, Elisa Camela
      PubDate: Thu, 28 Jul 2022 00:00:00 +000
  • Dermoscopy of cutaneous neurocristic hamartoma and report of its rare
           clinical presentation

    • Authors: Dincy Peter; Priya Kuryan, Ashish Kumar Gupta, Meera Thomas
      Abstract: NA
      PubDate: Thu, 28 Jul 2022 00:00:00 +000
  • A pink nodule with white halo: dermoscopy of halo melanoma

    • Authors: Francesco Borgia; Luca Di Bartolomeo, Marialorena Coppola, Maria Lentini, Elvira Moscarella, Mario Vaccaro
      PubDate: Thu, 28 Jul 2022 00:00:00 +000
  • Agminated Nevi Of The Foot With Checkerboard And Blaschkoid Distribution

    • Authors: Vito Ingordo; Nicola Licci, Stefano Caccavale, Gerardo Ferrara
      PubDate: Thu, 28 Jul 2022 00:00:00 +000
  • Lymphoma developing in a patient with long-term antitumor necrosis factor

    • Authors: Giovana Serrão Fensterseifer; André Vicente Esteves de Carvalho, Ana Letícia Boff, Joel Schwartz
      PubDate: Thu, 28 Jul 2022 00:00:00 +000
  • Calcinosis cutis in association with long-term stasis after electrical
           burn injury: a case report

    • Authors: Belkiz Uyar; Ömer Faruk Elmas, Emine Müge Acar, Sümeyra Has
      PubDate: Thu, 28 Jul 2022 00:00:00 +000
  • Square-shaped alopecia after embolization of intracranial aneurysm: case
           report and review

    • Authors: Jorge Roman-Sainz; Nicolás Silvestre-Torner, Fernando Gruber-Velasco, Belén Romero-Jiménez, Alejandro Lobato-Berezo, Adrián Imbernón-Moya
      PubDate: Thu, 28 Jul 2022 00:00:00 +000
  • Clinical, dermoscopic and radiological features of heel stick calcinosis

    • Authors: Keshavmurthy A. Adya; Arun C. Inamadar
      PubDate: Thu, 28 Jul 2022 00:00:00 +000
  • Iridescent changes observed during dynamic cross-polarized dermoscopy

    • Authors: John Paoli; Lykke Barck, Eva Johansson Backman, Ashfaq Marghoob, Sam Polesie
      PubDate: Thu, 28 Jul 2022 00:00:00 +000
  • Dermoscopy of Atrophic Dermatofibroma, a Rare Variant

    • Authors: Tugba Kevser Ustunbas Uzuncakmak; Bengu Cobanoglu Simsek
      PubDate: Thu, 28 Jul 2022 00:00:00 +000
  • Dermoscopy as a supportive tool to differentiate lichen amyloidosus from
           clinical mimickers

    • Authors: Emilia Noemi Cohen Sabban; Enzo Errichetti, Horacio A. Cabo, Esteban Maronna
      PubDate: Thu, 28 Jul 2022 00:00:00 +000
  • “Oak-leaf-like” loop vessels in super-high magnification dermoscopy of
           basal cell carcinoma

    • Authors: Joanna Pogorzelska-Dyrbuś
      Abstract: According. to the instructions for
      Authors , the Image Letter should not have an abstract
      PubDate: Thu, 28 Jul 2022 00:00:00 +000
  • A case of melanoma in a patient with psoriasis highlighting the importance
           of dermatoscopy and inflammoscopy.

    • Authors: Sarah Benton; Lori Ann Fiessinger, Juan Pablo Jaimes
      PubDate: Thu, 28 Jul 2022 00:00:00 +000
  • Retiform Hemagioendothelioma: Dermoscopic-pathological corelation

    • Authors: Saurabh Mittal; Naimah Aljassem
      PubDate: Thu, 28 Jul 2022 00:00:00 +000
  • A Particular Bicentric Structure in Dermoscopy of Degos Disease

    • Authors: Anqi Li; Rouyu Fang, Qiuning Sun
      PubDate: Thu, 28 Jul 2022 00:00:00 +000
  • Pilar leiomyomas: New dermoscopic pattern

    • Authors: Meryem Soughi; Fatima Zahra Mernissi
      PubDate: Thu, 28 Jul 2022 00:00:00 +000
  • Perinevoid alopecia: an unusual presentation of alopecia areata

    • Authors: Jose Leonardo Rodrigues Machado; Rita Fernanda Cortez de Almeida, Simone Carolina Frattini, Daniel Fernandes Melo
      PubDate: Thu, 28 Jul 2022 00:00:00 +000
  • An Exuberant Case of Retentional Acne: Chloracne

    • Authors: Philippe Visintainer Melo; Gabriela Fortes Escobar
      PubDate: Thu, 28 Jul 2022 00:00:00 +000
  • A solitary nodule over the chest

    • Authors: Gitesh Sawatkar; Nisha Meshram, Keshavamurthy Vinay
      PubDate: Thu, 28 Jul 2022 00:00:00 +000
  • Inflammatory Vitiligo

    • Authors: Hua-Ching Chang; Chun-Yu Lai, Yin-Shuo Chang
      PubDate: Thu, 28 Jul 2022 00:00:00 +000
  • Dermoscopy for facial leukotrichia in vitiligo: An important step for a
           better treatment decision

    • Authors: Mohammed Ibrahim AlJasser
      PubDate: Thu, 28 Jul 2022 00:00:00 +000
  • Dermatoscopy in the Diagnostics of Incontinentia Pigmenti Skin Lesions

    • Authors: Snezana Minic; Danijela Dobrosavljevic, Jovan Lalosevic, Dusan Trpinac
      Abstract: Introduction: Incontinentia pigmenti (IP) is a rare X-linked geno-dermatosis characterized by numerous findings. Skin biopsy and histopathological analysis are considered as minor criteria for the diagnosis of IP. We assume that dermoscopy can assist the earlier diagnosis of IP. Objectives: To gain experience in earlier diagnosis of IP by observing dermoscopic findings of cutaneous changes. Methods: We revised confirmed cases of IP and examined them using dermoscopy, comparing histopathological and dermoscopic results. Results: Stage I presented solitary and grouped vesicles in linear arrangement on erythematous skin. Early stage II presented star-shaped verrucous lesions on erythematous or pigmented skin. In well-developed lesions, dotted vessels surround keratotic part, some with thrombosed capillaries, resembling a viral wart. Stage III presented linear brown dots on the pigmented areas. Dermoscopic image was uniform in all the examined pigmented Blaschko linear changes. Stage IV presented numerous dotted vessels on the hypopigmented skin. Terminal hair was scarce or absent in all four stages. The surrounding normal skin had perifollicular depigmentations in stages III and IV. Conclusions: Dermoscopy of all four stages is very specific compared to the dermoscopy of inflammatory dermatoses and pigmentations. Stage III has very close clinical, histological and dermoscopic mimickers and needs to be carefully examined with obligatory genetic testing. Dermoscopy of the stage IV closely corresponds to histopathological findings and may be crucial as a quick tool in revealing potential IP gene carriers. Dermoscopy should be used in addition to clinical examination since the two methods are complementary.
      PubDate: Thu, 28 Jul 2022 00:00:00 +000
  • Nonsurgical Reshaping of the Lower Jaw With Hyaluronic Acid Fillers: A
           Retrospective Case Series

    • Authors: Raffaele Rauso; Luigi Rugge, Fabrizio Chirico, Giovanni Francesco Nicoletti, Romolo Fragola, Pierfrancesco Bove, Nicola Zerbinati, Giorgio Lo Giudice
      Abstract: Introduction: Non-surgical aesthetic treatments of the lower face are increasingly in demand, particularly aimed to restore facial youth following the changes secondary to a progressive resorption of facial skeleton and atrophy of facial fat compartments, which give the perception of a descent face. Objective: The aim of this research is to describe non-surgical reshaping of aged lower jaw by means of hyaluronic acid fillers. Methods: A retrospective analysis of data from adult female patients undergoing treatment of the lower third of the face with hyaluronic acid injections was performed. Injection techniques, relevant anatomy of the anatomical area and rheological properties of the fillers to be used are highlighted. Results: Thirty-six consecutive patients were enrolled (100% female; mean age, 45.7 years). A minimum of 4 vials, up to 7, of hyaluronic acid filler, were injected in order to achieve the desired results. Visual analog scale (VAS) was used to assess patient satisfaction. Thirty-two patients (88.8%) rated their appearance post-treatment with a satisfaction score ranging between 85 and 100%. Total absence of ecchymosis and/or swelling in the early post-operative days has been highlighted. There were no cases of infection, paresthesia, hematoma or necrosis. Conclusions: Jaw line remodeling with hyaluronic acid fillers, in patients not willing to undergo surgery, seems to be a viable option for ameliorating the definition of the lower third of the face, although it is mandatory to perform multi-layer injections using fillers with different rheological properties.
      PubDate: Thu, 28 Jul 2022 00:00:00 +000
  • Evaluation of MCV/RDW Ratio and Correlations with Ferritin in Telogen
           Effluvium Patients

    • Authors: Saadet İbiş; Gülhan Aksoy Saraç, Turan Akdağ
      Abstract: Objective: Telogen effluvium is one of the chronic diseases that affect the quality of life (QoL) in women. The study aimed to evaluate the RDW/MCV ratio and its correlation with ferritin in Telogen Effluvium patients and to reveal their potential role in the etiopathogenesis of Telogen effluvium. Material and Methods: We retrospectively evaluated the medical data of 250 patients who were admitted to the dermatology outpatient clinic between September 2020 and December 2020 with a diagnosis of Telogen effluvium. The control group was created retrospectively from the medical records of 250 healthy individuals. HB, HCT, MPV, MCV, RDW, ferritin, and MCV/RDW ratio of both groups were compared and evaluated statistically. Results: All of the Telogen effluvium patients were women in terms of gender. The mean age of the patient group was 33,11±9,66 years and the mean age of the control group was 34,98±12,37 years. The ratio of MCV/RDW, MPV, MCV, and ferritin is lower in the group with Telogen effluvium compared to the control group and a statistically significant difference was found(p<0.05). However, the correlation between MCV/RDW ratio and ferritin was evaluated in Telogen effluvium patients, and no significant differences were found (p>0.05). Conclusion: Iron deficiency anemia is thought of as a factor in female patients with telogen effluvium. Although the data shows the correction of iron deficiency is insufficient telogen effluvium, we proposed that laboratory tests should be routinely used in the diagnosis and treatment phase of patients who apply with the complaint of hair loss.
      PubDate: Thu, 28 Jul 2022 00:00:00 +000
  • Efficacy of a topical formulation of Henna (Lawsonia inermis) on the itch
           and wound healing in patients with epidermolysis bullosa: A pilot
           single-arm clinical trial

    • Authors: Mehdi Niazi; Mohammad Mahdi Parvizi, Nasrin Saki, Zahra Parvizi, Mehrzad Mehrbani, Mojtaba Heydari
      Abstract: Introduction: Epidermolysis bullosa (EB) is a rare inherited genetic skin disorder with severe skin itching and recurrent blisters and erosion. There is no effective and specific therapy for all types of EB. Objective: The aim of this study was to evaluate a topical formulation of henna (Lawsonia inermis L.) in the management of wounds and the itching sensation in patients with EB. Methods: This is a pilot single-arm clinical trial. Nine patients with recessive dystrophic EB (RDEB), with the age range of 5 to 32 years old were enrolled in the study. The patients were instructed to apply the topical 1% henna ointment once daily on two erosions and on also two sites with moderate to a severe itching sensation. The total duration of the intervention was four weeks with weekly follow-up visits. Patient global impression of improvement (PGI-I), visual analog scale (VAS), and clinical global impression of improvement (CGI-I) were used for assessing the wound healing process and itching discomfort. Results: There was a significant improvement in the skin symptoms of epidermolysis bullosa including skin redness, itching, burning, and local warmness (p-value<0.05). Local pain decreased during the study period, but this was not statistically significant (p-value<0. 0.19). One patient reported moderate xerosis of skin after continuous usage. Conclusion: It seems that the topical formulation of henna may be effective in the management of itching, burning, stringing, and cutaneous warmness sensation in patients with EB. Further controlled studies with larger sample sizes are recommended to better evaluate this formulation.
      PubDate: Thu, 28 Jul 2022 00:00:00 +000
  • Cutaneous Manifestations and Their Corresponding Dermoscopic Features in
           Patients with Dermatomyositis

    • Authors: Joana Pozharashka; Ljubka Miteva, Lyubomir Dourmishev
      Abstract: Introduction: Dermoscopy is a noninvasive and easy to apply technique that allows in vivo magnification of the skin and thus observation of morphologic structures invisible to the naked eye. Recently, it gained popularity for evaluation of inflammatory skin conditions. In the field of connective tissue diseases, dermoscopy has been used mainly as a simple and accessible substitute of nailfold capillaroscopy. Objectives: The aim of the present study is to expand the application of dermoscopy in patients with dermatomyositis (DM) beyond the usual nailfold examination. A clinico-dermoscopic correlation is also suggested. Methods: A total of twenty-nine patients with DM were enrolled in this descriptive prospective study, conducted over a three-year period. Dermoscopy was performed by a DermLite DL1 dermatoscope on polarization mode, attached to One Plus 3T camera. The following skin lesions were examined - periungual affection, scalp DM, Gottron’s papules, palmar papules, poikiloderma and auricular changes. Results: Dermoscopy detected predominantly advanced nail fold capillary changes - giant capillaries (79%), microhemorrhages (46%) and avascular areas (25%). The most prevalent trichoscopic features were enlarged tortuous capillaries (64%), interfollicular scales (50%) and peripilar casts and tufting (36%). Among the other skin lesions assessed in this study - Gottron's papules were present in 20 patients, poikiloderma in 11, palmar papules in 4 and auricular lesions in 4 patients.
      PubDate: Thu, 28 Jul 2022 00:00:00 +000
  • Comparison of convolutional neural network architectures for robustness
           against common artefacts in dermatoscopic images

    • Authors: Florian Katsch; Christoph Rinner, Philipp Tschandl
      Abstract: Introduction: Automated classification of dermatoscopic images via neural networks shows comparable performance to clinicians in experimental conditions, but can be affected by artefacts like skin markings or rulers. It is unknown whether specialized neural networks are equally affected, or more robust to artefacts. Objectives: Analyse robustness of three neural network architectures, namely ResNet34, Faster R-CNN and Mask R-CNN. Methods: We identified common artefacts in the public HAM10000, PH2 and the 7-point criteria evaluation datasets, and established a template-based method to superimpose artefacts on dermatoscopic images. The HAM10000-dataset with and without superimposed artefacts was used to train the networks, followed by analysing their robustness against artefacts in test images. Results: ResNet-34 and Faster R-CNN models trained on regular images perform worse than the Mask R-CNN models when tested on images with superimposed artefacts. Artefacts in all tested images led to a decrease in area under the precision-recall curve values of 0.030 for ResNet-34 and 0.045 for Faster R-CNN in comparison to only 0.011 for Mask R-CNN. However, changes in model’s performance only became significant with 40% or more of the images having superimposed artefacts. We could also show that loss in performance occurs when the training was biased by selectively superimposing artefacts on images belonging to a certain class. Conclusions: Instance segmentation architectures may be helpful to counter the effects of artefacts, and further research on related architectures of this family should be promoted. Our introduced template-based artefact insertion mechanism could be useful for future research.
      PubDate: Thu, 28 Jul 2022 00:00:00 +000
  • Facial dermatoses in patients with blepharitis: a cross-sectional
           prospective analysis.

    • Authors: Semih Güder; Şafak Çulfa
      Abstract: Introduction: The relationship between facial dermatoses and blepharitis has been known for a
      long time.
      Objectives: We aimed to investigate the frequency of accompanying facial dermatoses in patients with
      blepharitis and their relationship with the severity of blepharitis.
      Methods: In this cross-sectional study, 95 patients with blepharitis were examined for attending facial
      dermatoses. The type of blepharitis, the severity of blepharitis, and the degree of dry eye were
      determined in the patients. Dermoscopic and microscopic examinations were used in the diagnosis of
      facial dermatoses. The history of allergic rhinitis was questioned because Demodex species frequently
      accompany blepharitis, facial dermatoses, and allergic rhinitis patients. Mann-Whitney U test was
      used compare 2 independent groups. In comparing categorical variables, Pearson chi-Squared, Fishere
      Exact, and Fisher-Freeman-Holton tests were used.
      Results: At least 1 facial dermatosis was detected in 84.2% patients, and we did not see any facial
      dermatosis in 15.8% ones. No patients had acne, which is one of the most common facial dermatoses.
      The most common facial dermatosis detected in our patients was facial demodicosis (57.9%). It was
      followed by seborrheic dermatitis (22.1%) and rosacea (12.6%), respectively. In addition, 2.1% of the
      patients had atopic eyelid dermatitis, 23.2% had a history of allergic rhinitis, and 63.2% had ocular
      Conclusions: It is essential to perform dermatological examinations of all patients with blepharitis in
      terms of accompanying facial dermatoses and their early diagnosis.
      PubDate: Thu, 28 Jul 2022 00:00:00 +000
  • Retrospective Analysis of Dermatological Diseases in Geriatric Patients
           During Dermatology Outpatient Department Visits

    • Authors: Gulhan Aksoy Sarac; Mehmet Ali Can Emeksiz, Onur Acar, Ersin Nazlıcan, Efsun Tanacan, Tufan Nayir
      Abstract: Introduction: Elderly population is vulnarable to experience a great number of dermatological diseases thanks to the intrinsic and extrinsic process of aging. Objectives: The aim of this study is to retrospectively investigate the prevalence of dermatological diseases in geriatric patients, their distribution by age and gender, and to provide a reference for studies on aging and skin problems. Methods: In the present study, patients who reported to the dermatology outpatient clinic between January 1, 2019 and January 1, 2021 were evaluated retrospectively. As a result of examining the records of patients, 887 patients over the age of 65 who met the study protocol were included. Results: The three most common diseases in all geriatric patients were fungal infections, eczematous dermatitis, and pruritus. Fungal infections were frequent in males and the 65-74 ages group. In the males, the more frequent was precancerous lesions and malignant neoplasms, whereas in the females it was urticaria and adverse drug reactions. In the logistic regression model, the risk of fungal infection in geriatric patients was increased by being male (OR: 1.55 p=0.006) and being in the range of 65-74 years old (OR: 1.46 p=0.025). Male patients were at significantly higher risk for precancerous and malignant lesions (OR:2.81 p<0.001) and actinic keratosis (OR:3.26 p<0.001) in this disease group. Conclusions: Men are more vulnerable to life-threatening skin diseases. It is important to determine risk factors for individuals who are more sensitive to environmental factors in terms of increasing the quality of life and protection from diseases.
      PubDate: Thu, 28 Jul 2022 00:00:00 +000
  • Can immunofluorescence on Tzanck smear be used as a substitute for direct
           immunofluorescence on skin biopsy in diagnosis of pemphigus disease'

    • Authors: Mohammad Shahidi Dadras; Zahra Asadi Kani, Behnaz Hamedani, Sahar Dadkhahfar, Nazy Rastgoo, Nikoo Mozafari
      Abstract: Introduction: Few studies have been conducted on the use of Direct Immunofluorescence (DIF) on skin/mucosal scraping smear for diagnosis of pemphigus disease; however, the diagnostic value of DIF on the smear has not been fully evaluated. Objectives: to assess the sensitivity and specificity of DIF on skin/mucosal smear for diagnose of pemphigus in the patients presenting with mucocutaneous erosive lesions. Methods: A total of 89 patients including 40 males and 49 females aged between 23 and 80 years old with various bullous disorders were enrolled in the study. For definite diagnosis, all the patients were subjected to lesional biopsy for pathological studies and perilesional biopsy for DIF studies. In all the cases, skin/mucosal scraping smears were prepared from the perilesional healthy skin/mucosa and were stained with immunofluorescence conjugated anti-IgG. Results:Of 89 patients, 56 (63%) patients were diagnosed with pemphigus. Immunodeposits favoring the pemphigus were demonstrated in the 46 smears of 56 cases of pemphigus (sensitivity of 82%). No case with other types of bullous disease had positive DIF on the smear (specificity of 100%). Conclusion: The findings of the study showed that the sensitivity of DIF on the smear is not high enough to allow us replacing the conventional DIF with smear-DIF for diagnosis of pemphigus, while the specificity of 100% would allow the unequivocal identification of a subset of patients with pemphigus.
      PubDate: Thu, 28 Jul 2022 00:00:00 +000
  • Habits of using social media and the internet in psoriasis patients

    • Authors: Melek Aslan Kayıran; Ayşe Serap Karadağ, İlteriş Oğuz Topal, Esra Adışen, Sevilay Kılıç, Nuray Keskin, Asude Kara Polat, Bengü Çevirgen Cemil, Mualla Polat, Oğuz Yılmaz, Hilal Ayvaz, Filiz Topaloğlu Demir, Sezgi Sarıkaya Solak, Derya Uçmak, Mehmet Salih Gürel, Sema Aytekin, Algün Polat Ekinci, Kübra Nursel Bölük, Neslihan Şendur, Tuğba Özkök Akbulut, Günseli Öztürk, Ayda Acar, Erkan Alpsoy
      Abstract: Introduction: Psoriasis significantly affects the patients’ quality of life, which often leads patients to seek online information about this disease. Objectives: To explore the habits of patients with psoriasis related to their use of SM and the internet to obtain information about their disease. Methods: 1,520 patients completed the survey and the Dermatology Life Quality Index (DLQI) questionnaire. The Psoriasis Area Severity Index scores (PASI) and clinical data of the patients were recorded by their physicians. Results: Of the 1,114 patients that reported using social media (SM) and the internet, 48.38% regularly and 31.14% sometimes resorted to obtain information about psoriasis. The use of SM and the internet for psoriasis was statistically significantly higher among young people (p=0.000), those with university or higher education (p=0.009), higher DLQI (p=0.000) and PASI (p=0.011) scores, facial (p=0.050), scalp (p=0.032), hand (p=0.048), genital (p=0.001) and inverse (p=0.000) involvement, and arthralgia/arthritis (p=0.006). The participants mostly used the Google (86%) and Facebook (%41). More than half the participants (62.8%) expected dermatologists to inform society that psoriasis is not contagious. Conclusion: The internet and SM being widely available and offering substantial information to be easily accessed make it very attractive for patients to use these platforms to investigate diseases, including psoriasis. If what is presented on SM conflicts with what the physician says, patients mostly trust the latter, but at the same time, they tend not to share the results of their online inquiries with their physicians.
      PubDate: Thu, 28 Jul 2022 00:00:00 +000
  • Evaluation of Diagnostic Accuracy and Therapeutic Approach of
           Dermatologists and Plastic Surgeons to Non-Melanocytic Skin Lesions by
           Using Telemedicine

    • Authors: Burcu Tugrul; Basak Yalici-Armagan, Hatice Gamze Demirdag, Ozge Gunduz
      Abstract: Background: In the new circumstances of Coronavirus disease 2019 pandemic, teledermatology and teledermoscopy have become more important in daily practice for departments which visuality is at the forefront as dermatology and plastic and reconstructive surgery. Objective: In this study, it is aimed to determine diagnostic accuracy and treatment approaches of non-melanocytic skin lesions between two clinics by store and forward teledermatology method and to evaluate the contribution of teledermoscopy to the diagnostic accuracy of dermatologists. Methods: A total of 26 patients with non-melanocytic skin lesions were included to the study. Clinical images of the lesions were sent by email to three plastic surgeons and three dermatologists. The accuracy of the diagnoses were evaluated by comparing teledermatology with histopathology. Diagnosis and treatment approaches were recorded for both clinics. Dermatologists also defined their diagnosis with teledermoscopic images. Results: The mean percentage of diagnostic accuracy among dermatologists’ was 74.3% and among plastic surgeons’ was 61.5%. There was no significant difference in diagnostic accuracy between departments (p=0.625). There was a statistically significant difference between the departments for diagnostic and treatment approaches (p values respectively p=0.002, p<0.001). Plastic surgeons prefered to confirm their pre-diagnosis histopathologically more than dermatologists. Plastic surgeons recommended surgical procedures for 25 lesions (96.2%) while dermatologists for 14 (53.8%) lesions. Teledermoscopy increased the rate of diagnostic accuracy of dermatologists from 74,3% to 82%. Conclusions: Teledermatology is an effective method for non-melanocytic skin lesions with high diagnostic accuracy. Adding dermoscopy to teledermatology increases diagnostic accuracy of dermatologists on non-melanocytic skin lesions.
      PubDate: Thu, 28 Jul 2022 00:00:00 +000
  • An updated algorithm integrated with patient data for the differentiation
           of atypical nevi from early melanomas: the idScore 2021

    • Authors: Linda Tognetti; Alessandra Cartocci, Martina Bertello, Mafalda Giordani, Elisa Cinotti, Gabriele Cevenini, Pietro Rubegni
      Abstract: Background: It is well known that multiple patient-related risk factors contribute to the development of cutaneous melanoma, including anagraphic, phenotypic and anamnestic factors. Objectives: We aimed to investigate which MM risk factors were relevant to be incorporated in a risk scoring-classifier based clinico-dermoscopic algorithm. Methods: This retrospective study was performed on a monocentric dataset of 374 atypical melanocytic skin lesions (aMSLs) sharing equivocal dermoscopic features, excised in the suspicion of malignancy. Dermoscopic standardized images of 258 atypical nevi and 116 early melanomas were collected along with objective lesional data (i.e., maximum diameter, specific body site and body area) and 7 dermoscopic data. All cases were combined with a series of 10 MM risk factors, including anagraphic (2), phenotypic (5) and anamnestic (3) ones. Results: According to the stepwise analysis logistic regression, the proposed iDScore 2021 algorithm is composed by 9 variables, including 3 patient data (age, skin phototype I/II, personal/familiar history of MM), 2 lesion characteristics (maximum diameter, location on the lower extremities (thighs/legs/ankles/back of the feet) and 4 dermoscopic features (irregular dots and globules, irregular streaks, blue gray peppering, blue white veil). The algorithm assigned to each lesion/case a progressive score from 0 to 18. The performance obtained in the ROC curve analysis reached 92% AUC in differentiating early melanomas from atypical nevi. Conclusions: An integrated checklist combining multiple anamnestic data with selected relevant dermoscopic features can be useful in the differential diagnosis and management of early melanomas and atypical nevi exhibiting equivocal features.
      PubDate: Thu, 28 Jul 2022 00:00:00 +000
  • Dermoscopic Photographs Impact Confidence and Management of Remotely
           Triaged Skin Lesions

    • Authors: Tova Rogers; Myles Randolph McCrary, Howa Yeung, Loren Krueger, Suephy Chen
      Abstract: Background: Improving remote triage is crucial given expansions in teledermatology and with limited in-person care during COVID-19. In addition to clinical pictures, dermoscopic images may provide utility for triage.   Objective: To determine if dermoscopic photographs enhance confidence, triage accuracy, and triage prioritization for teledermatology.   Methods: In this parallel convergent mixed-methods study, a cohort of dermatologists and residents assessed skin lesions using clinical and dermoscopic photographs. For each case, participants viewed a clinical photograph and determined diagnostic category, management, urgency, and decision-making confidence. They subsequently viewed the associated dermoscopy and answered the same questions. A moderated focus group discussion followed to explore perceptions on the role of dermoscopy in teledermatology.   Results: Dermoscopy improved recognition of malignancies by 23% and significantly reduced triage urgency measures for non-malignant lesions. Participants endorsed specific utilities of teledermoscopy, such as for pigmented lesions, with limitations including poor image quality.   Conclusions: Dermoscopic photographs may be useful when remotely triaging skin lesions. Standardized imaging protocols are needed.
      PubDate: Thu, 28 Jul 2022 00:00:00 +000
  • Comparison of early (EOP) and late onset psoriasis (LOP) regarding
           systemic inflammatory comorbidities: LOP is a more rapid subtype of

    • Authors: Leyla Huseynova Terzi; Sibel Dogan Gunaydin
      Abstract: Background: Early onset psoriasis (EOP) and late onset psoriasis (LOP) differs regarding genetic background, clinical presentation, and course of disease. Objective: In this study, comparison of EOP and LOP regarding systemic inflammatory comorbidities which are frequently seen in psoriasis and determination of possible differences is aimed. Methods: A total of 160 plaque psoriasis patients; 121 with EOP and 39 with LOP were enrolled for the study. Data was collected with face-to-face questionnaire and patients’ medical chart evaluation. Collected data included medical and family history, clinical features and parameters indicating severity of psoriasis, results of laboratory work-up, physical and dermatological examination findings, presence of joint and nail involvement and associated inflammatory systemic comorbidities such as cardiovascular diseases (CVD), diabetes mellitus (DM), hypertension (HT), metabolic syndrome (MS), obesity. Results: Nail involvement and PsA occurred more rapidly in LOP compared to EOP (p<0.01, p<0.01). Compared frequencies in LOP and EOP were 7.7% vs 0.8% for CVD, 38.5% vs 14% for HT, 33.3% vs 9.9% for DM and 44.7% vs 24.8% for MS respectively. CVD, HT, DM and MS were significantly more frequent in LOP compared to EOP (p=0.045, p=0.001, p<0.01, p=0.022). Results of multivariate analysis performed taking into account the age, gender, severity parameters of disease, alcohol consumption, smoking habits, and other concurrent systemic comorbidities revealed LOP to be an independent risk factor for CVD and DM (p<0.01, R2: 0.036, p<0.01, R2: 0.077).   Conclusion: LOP seems to interact with systemic comorbidities hence generating more severe inflammatory burden and shows a more rapid course.
      PubDate: Thu, 28 Jul 2022 00:00:00 +000
  • Sonographic Characteristics of Leiomyomatous Tumors of Skin and
           Nail—A Case Series

    • Authors: Eyal Taleb; Cristobal Saldias, Sergio Gonzalez, Carlos Misad, Ximena Wortsman
      Abstract: Introduction - The clinical appearance of the uncommon cutaneous leiomyomatous tumors (LMT) is nonspecific, leading to an extensive differential diagnosis. A non-invasive tool such as high-frequency ultrasound (HFUS) is required for characterizing LMTs in the clinical setting. Although the sonographic features of their uterine counterpart had been well reported, there are only scant reports on the use of ultrasound (US) for studying leiomyomatous neoplasms of the skin and nail. Objectives and methods – We Characterized common sonographic features of LMT using HFUS in three patients, two of them with multiple cutaneous leiomyomas and another with a subungual leiomyosarcoma. Results – In all cases, several shared ultrasound (US) characteristics were found. Moreover, we describe a new ultrasonographic sign in cutaneous leiomyomas called the “pine tree” sign, with other features not previously reported. Conclusion - These ultrasonographic characteristics would strengthen the clinical diagnosis, assist with treatment management, and may help avoid serial biopsies in cases with multiple cutaneous lesions.
      PubDate: Thu, 28 Jul 2022 00:00:00 +000
  • Elevated Serum Levels of Interleukin-15 in Pemphigus Vulgaris Patients: A
           Potential Therapeutic Target

    • Authors: Maedeh Kheirodin; Zohreh Tehranchinia, Yasaman Ketabi, Soheil Tavakolpour, Sahar Dadkhahfar, Masoomeh Faghankhani, Hassan Vahidnezhad, Nikoo Mozafari
      Abstract: introduction: IL-15 as a member of the immunoregulatory cytokines family is associated with the development of the autoimmune or chronic inflammatory disease. objectives: The goal of this study was to evaluate the serum levels of IL-15 in patients with pemphigus vulgaris and assess the association of IL-15 with anti-desmoglein antibodies and the severity of the disease. methods: fifty-three individuals affected with active pemphigus Vulgaris and 38 age and gender-matched healthy controls were enrolled in this study. Clinical characteristics and Autoimmune Bullous Skin Disorder Intensity Score (ABSIS) were assessed. Serum levels of IL-15 (pg/mL) and anti-desmoglein antibodies (Dsg1, 3) were measured. Result: The serum level of IL-15 in the patient group was assumed to be statistically higher than that of the control group (3.71 ± 1.5 vs. 0.79 ± 1.03 (p< 0.001)). A positive correlation was found between serum levels of IL-15 and severity of pemphigus Vulgaris measured by ABSIS (r=0.5, p=0.04). No significant relationship was detected between the serum level of IL-15 and antidesmoglein antibodies (Dsg1 or Dsg3). (p=0.6 and p=0.9, respectively). Conclusion: our findings showed that levels of IL‐15 were elevated in the sera of pemphigus patients and were related to disease severity. An increase in serum level of Il-15 in patients with pemphigus Vulgaris and its relation with disease severity suggest that this cytokine may play a role in the pathogenesis of the disease and targeting IL-15 will likely provide a new perspective on the treatment of this disease.
      PubDate: Thu, 28 Jul 2022 00:00:00 +000
  • How are Acne Vulgaris Patients Using Oral Isotretinoin Affected by

    • Authors: Mine Müjde Kuş; Perihan Öztürk, Tutku Bulut, Celal Kuş, Mehmet Enes Güner, Hülya Nazik, Mehmet Kamil Mülayim
      Abstract: Introduction: It has been reported that the use of oral isotretinoin may have positive and negative effects on the course of COVID-19 and the risk of transmission. Objectives: The purpose of our study is to evaluate how our patients that took oral isotretinoin during the pandemic were affected by COVID-19. Methods: The clinical processes of moderate-to-severe acne vulgaris patients between March 2020 and February 2021 were evaluated. Results: Of 102 moderate-to-severe acne patients, 67 were using oral isotretinoin and 35 were using a topical treatment. Of 27 patients who tested positive for COVID-19, 16 (59.3%) were using oral isotretinoin and 11(40.7%) were using topical treatment, there was no statistical difference in the rates of COVID-19 positivity between the two groups (P = 0.412). The rates of positive tests for COVID-19 were similar between contacted patients of two groups (P = 0.391). Loss of smell/taste was lower in patients using oral isotretinoin compared to patients receiving topical treatment (46.7% and 72.7%, respectively.). Headache symptoms were less common in patients using oral isotretinoin (P = 0.047). Conclusions: The use of oral isotretinoin did not cause an increase or decrease in the risk of COVID-19 transmission. The patients using oral isotretinoin had a lower incidence of taste/smell loss and headache.
      PubDate: Thu, 28 Jul 2022 00:00:00 +000
  • Application of an interactive diagnosis ranking algorithm in a simulated
           vignette-based environment for general dermatology

    • Authors: Antonia Wesinger; Elisabeth Riedl, Harald Kittler, Philipp Tschandl
      Abstract: Background: Diagnostic algorithms may reduce noise and bias and improve interrater agreement of clinical decisions. In a practical sense, algorithms may serve as alternatives to specialist consultations or decision support in store-and-forward teledermatology. It is, however, unknown how dermatologists interact with algorithms based on questionnaires.    Objective: To evaluate the performance of a questionnaire-based diagnostic algorithm when applied by users with different expertise.   Methods: We created 58 virtual test cases covering common dermatologic diseases and asked five raters with different expertise to complete a predefined clinical questionnaire, which served as input for a disease ranking algorithm. We compared the ranks of the correct diagnosis between users, analysed the similarity between inputs of different users, and explored the impact of different parts of the questionnaire on the final ranking.    Results: When applied by a board-certified dermatologist, the algorithm top-ranked the correct diagnosis in the majority of cases (median rank 1; IQR: 1.0; mean reciprocal rank 0.757). The median rank of the correct diagnosis was significantly lower when the algorithm was applied by four dermatology residents (median rank 2-5, p<.01 for all). The lowest similarity between inputs of the residents and the board-certified dermatologist was found for questions regarding morphology. Sensitivity analysis showed the highest deterioration in performance after omission of information on morphology and anatomic site. 
      Conclusions: A simple questionnaire-based disease ranking algorithm provides accurate ranking for a wide variety of dermatologic conditions. When applied in clinical practice, additional measures may be needed to ensure robustness of data entry for inexperienced users.
      PubDate: Thu, 28 Jul 2022 00:00:00 +000
  • Infantile hemangioma and cardiac defects: a puzzling association. A single
           center experience

    • Authors: Andrea Bassi; Andrea Azzarelli, Angelina Vaccaro , Carlo Mazzatenta
      Abstract:   BACKGROUND: Some studies have assessed the incidence of heart defects in children suffering from Infantile Hemangioma to be treated with propranolol, showing a possible higher prevalence of cardiac abnormalities in this group of patients. METHODS: We retrospectively reviewed clinical charts of children with infantile haemangiomas referred to our Dermatologic division from 2016 to 2021, who underwent our pediatric cardiology protocol screening before starting propranolol therapy. RESULTS: A total of 60 infants were enrolled. Electrocardiograms were available for all the patients and echocardiograpy for 50/60 (83.3%) children. Electrocardiogram didn’t reveal any alterations in the large majority of cases (pathologic in 2/60, 3.3%) while echocardiograms revealed findings in 31/50 (51.7%) patients. Of these, persistent foramen ovale, which was found in 14/50 patients (28%), was considered as non-pathologic. Interatrial septal defects were the main pathological finding in 15/50 patients (30%), as single defect or in association with other abnormalities.    CONCLUSION: Our study confirms the presence of a higher rate of cardiologic findings in patients with infantile hemangioma evaluated before starting oral propranolol, compared to the known rate of those defects in healthy newborns. We also confirm that interatrial septal defects are the most frequent pathologic finding with a higher prevalence compared to published studies. Large prospective studies are needed to clarify a possible association of pathological cardiac findings in all patients with infantile hemangiomas and thereafter to evaluated the possible effect of propranolol therapy on these defects during time.    
      PubDate: Thu, 28 Jul 2022 00:00:00 +000
  • Dermoscopic evaluation of extragenital lichen sclerosus et atrophicus

    • Authors: Sunanda Arun Mahajan; Jayati Shailesh Dave
      Abstract: Introduction: Lichen sclerosus (LS), is an uncommon inflammatory dermatosis with preferential involvement of anogenital region. Diagnosis of LS is mainly clinical, but clinical differentiation from conditions like vitiligo, morphea may be a difficult task at times that often requires histological analysis. Dermoscopy is one such non-invasive tool which can help diagnose the disease. There is paucity of Indian data on dermoscopy of LS. Objectives: To evaluate clinical, dermatoscopic patterns of LS and correlate them with histopathology. Methods: The study was conducted in a tertiary hospital after obtaining consent from 20 patients. OITEZ e-scope digital microscope was used to evaluate the lesions. Both polarized and nonpolarized mode were used and skin biopsy was done to confirm diagnosis. Results: Based on morphology, LS was classified as scleroatrophic lesions (61.5%), guttate lesions (30.8%) and hyperkeratotic lesions (7.7%). Dermoscopic analysis revealed structureless white to yellow areas as most common finding (100%) followed by chrysalis like structure (80.8%). Linear irregular vessels were seen in 61.5% lesions and perifollicular scaling in 50.0% lesions. Keratotic plugs were seen in 50.0% lesions. A new characteristic finding, “rosettes” was seen in 38.5% lesions has never been reported with LS before. Non polarized mode was particularly useful for identifying texture changes, keratotic plugs and minute scales which were not visible otherwise.Conclusions: Dermoscopy is a simple diagnostic tool that helps in the early diagnosis of LS with specific pattern which can avoid invasive procedure like biopsy. Both non-polarised and polarized dermoscopy must be done to visualize the changes of LS well.
      PubDate: Thu, 28 Jul 2022 00:00:00 +000
  • Dermoscopy for acral melanocytic lesions: Revision of the 3-step algorithm
           and refined definition of the regular and irregular fibrillar pattern

    • Authors: Toshiaki Saida; Hiroshi Koga, Hisashi Uhara
      PubDate: Thu, 28 Jul 2022 00:00:00 +000
  • Dermoscopy for Cutaneous Melanoma: under the eye of both the dermatologist
           and the legal doctor

    • Authors: Vittorio Bolcato; Andrea Michelerio
      PubDate: Thu, 28 Jul 2022 00:00:00 +000
School of Mathematical and Computer Sciences
Heriot-Watt University
Edinburgh, EH14 4AS, UK
Tel: +00 44 (0)131 4513762

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