| Publisher: Mattioli 1885 srl (Total: 9 journals) [Sort alphabetically]
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Dermatology Practical & Conceptual
Number of Followers: 2  Open Access journalISSN (Online) 2160-9381 Published by Mattioli 1885 srl  [9 journals]
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- A Retrospective Review of Chronic Non-Communicable Dermatoses Among Older
Adults at a Tertiary Healthcare Facility in Southwestern Nigeria
Authors: Atinuke Ajani; Fatai Olatunde Olanrewaju, Ademola Enitan, Olufikemi Fabusuyi, Mufutau Oripelaye, Olumayowa Ambimbola Oninla, Olayinka Olasode
Abstract: Introduction: Aging is a ubiquitous human trait that predisposes older persons to chronic diseases. Compared with systemic non-communicable diseases, a significant gap exists in literature on the burden of non-communicable dermatoses (NCDs) amongst older adults, particularly in low and middle-income countries. Objectives: The aim of this study was to document the epidemiology and clinical pattern of non-communicable skin diseases among older adults in Nigeria. Methods: We conducted a retrospective review of medical records of ambulant adults aged ≥60 years referred for dermatological care at a teaching hospital in Southwestern Nigeria between February 2017 and February 2022. The frequency and pattern of NCDS were recorded for descriptive statistical analysis using SPSS 20 statistics software. The level of statistical significance was set at 0.05. Result : A total of 553 medical records were reviewed with a female: male ratio of 1.3:1 The mean age of the study population was 68.85 ±7.87. Six out of every 10 patients (60.6%) had at least one chronic NCD. The incidence of chronic NCDs declined with increasing age. Chronic eczemas (22.4%), pigmentary dermatoses (9.4%), and skin tumors (8.7%) were the most frequent chronic non-communicable dermatoses recorded. Older males had a significantly higher incidence of chronic eczemas while chronic urticarias and skin tumors demonstrated significant female preponderance. Conclusion: There is a high burden of Chronic NCDs with significant gender disparities among older adults with skin problems in Nigeria. Pre-emptive planning and resource allocation towards specialist geriatric-dermatology services are needed to address the skin-health needs of the growing geriatric population.
PubDate: Tue, 31 Oct 2023 00:00:00 +000
- Assessment of Vulvar Intraepithelial Neoplasia (VIN) Grades Based on
Dermoscopic Features: A Diagnostic Study
Authors: Vincenzo De Giorgi; Elisabetta Magnaterra, Biancamaria Zuccaro, Manfredi Magliulo, Vincenza Maio, Angela Mucilli, Federico Venturi, Ignazio Stanganelli, Daniela Massi
Abstract: Introduction: Vulvar intraepithelial neoplasia (VIN) is a vulvar skin lesion considered a precursor of vulvar squamous cell carcinoma. No characteristics have been discovered to date that allows us to differentiate between degrees of VIN. Objectives: The aim of this study was to correlate the clinical and dermoscopic features of VIN cases with histopathological findings. Methods: A prospective study of the clinical and dermoscopic characteristics of VINs was recruited. Data on clinical and dermoscopic characteristics, histopathology, were collected from the two Italian Dermatology Units from January 2020 and December 2021. Results: The study population consisted of 20 patients with a histologically confirmed diagnosis of VIN. At the dermoscopic level, VIN1 was characterized by a homogeneous erythematous area that completely involved the entire lesion, with a vascular pattern consisting of regular glomerular vessels. VIN3, was characterized by the presence of compact milky white areas that involved almost the entire lesion. VIN2 was characterized by the presence of non-compact white areas that allowed homogeneous erythematous areas to be seen transparently, without other distinguishing aspects. Conclusions: Although a definitive diagnosis and grading of VIN remains confirmed only histopathologically, our study shows how dermoscopy may aid the differential diagnosis between the different grades of VIN; the presence of a compact milky white area that involves nearly the entire lesion should be interpreted as an alarming feature, while homogeneous erythematous areas or a glomerular vascular pattern are more typical of the first stage of this neoplasia.
PubDate: Tue, 31 Oct 2023 00:00:00 +000
- Dermatoscopic Patterns in Childhood Vitiligo and Their Association With
Reflectance Confocal Microscopy Findings
Authors: Juan Alberto Godínez-Chaparro; Rodrigo Roldán-Marín, Adrián Soto-Mota, Claudia Camelia Calzada-Mendoza
Abstract: Introduction: The diagnosis of vitiligo is mainly based on clinical findings. However, dermoscopy or reflectance confocal microscopy (RCM) could be useful for assessing its progression (stability, pigmentation, or depigmentation). Objective: To evaluate the correlation of dermatological findings by dermoscopy and RCM in pediatric vitiligo. Methods: We conducted a cross-sectional, descriptive, and analytical clinical study. Pediatric patients with vitiligo of both sexes, aged >1 year and <18 years, with all spectrums of the disease were included. Vitiligo lesions were evaluated clinically, by dermoscopy, and microscopy. Results: A total of 40 patients with vitiligo were included. Eight dermoscopic patterns were found: reduced/absent pigment network, perifollicular pigmentation, trichromic, tapioca sago, perifollicular depigmentation, starburst, leukotrichia, and erythema. Skin with a normal pigment network showed complete dermal papillary rings and half-rings. Skin with reduced/absent pigment network had an absence of papillary rings or only showed half-rings and was more common in unstable vitiligo. The trichrome pattern only showed half-rings. The tapioca sago pattern showed complete papillary rings and appeared in younger patients. Perifollicular pigmentation showed half-rings and complete rings and did not show associations. The diffuse borders did not present complete papillary structures. We found that vitiligo duration time of <24 months (OR 4.56 CI 1.09-18.99) and absent papillary rings (OR 2.75 CI 1.01-7.51) are associated with an unstable prognosis. Conclusions: The dermoscopic and microscopic findings, such as the reduction/absence of the pigment network, tapioca sago pattern, and absence of papillary rings, can be used to support the evaluation of the clinical prognosis of vitiligo.
PubDate: Tue, 31 Oct 2023 00:00:00 +000
- Has the Use of the Mask Exacerbated Rosacea During the Pandemic'
Authors: Ilaria Trave; Ilaria Salvi, Emanuele Cozzani, Rebecca Donadoni, Aurora Parodi
Abstract: Introduction: During the COVID-19 pandemic, personal protective equipment, particularly face masks, has become an essential requirement to engage in social activities. Several articles reported an increase of recurrences of dermatologic facial diseases (i.e., acne, rosacea) related to mask use. Objectives: To evaluate the number of recurrences of rosacea related to face mask use. Methods: This prospective study was conducted on adult patients with a pre-pandemic diagnosis of mild and moderate papulopustular rosacea. All patients had previously achieved either partial or complete remission after a 4-month treatment with ivermectin in 2019. We collected data in two different phases characterized by different intensity of mask use during the pandemic and post-pandemic period. We collected data through clinical assessment of the disease, questionnaires on personal habits and standardized skin surface biopsy to study the Demodex mites count. Results: We enrolled a total of 30 patients. In the pandemic period, 5/30 patients had a relapse of mild papulopustular rosacea; the Demodex sample resulted positive in 4/5 relapsed patients. In the post-pandemic period, 4/30 patients reported a relapse of mild (3 patients) and moderate papulopustular rosacea (1 patient). At the Demodex exam, 1/4 relapsed patients resulted positive. Conclusions: We did not find a significant increase in relapses of papulopustular rosacea during the pandemic. An appropriate anti-parasitic treatment may reduce the number of recurrences due to mask use.
PubDate: Tue, 31 Oct 2023 00:00:00 +000
- Evaluation of Thiol Disulfide Homeostasis and Ischemia-Modified Albumin
Levels as an Indicator of Oxidative Stress in Acne Vulgaris
Authors: Zeynep Büşra Balık; Ahmet Rıfat Balık, Esra Fırat Oğuz, Özcan Erel, Mustafa Tunca
Abstract: Introduction: Acne vulgaris (AV) is the most common skin disease. AV is a skin disease often associated with oxidative stress. Thiols and ischemia modified albumin (IMA) analysis are used as oxidative stress markers. Objectives: In this study, it was aimed to evaluate the blood levels of thiols and IMA, which are accepted as oxidative stress markers, and to determine the severity of the disease in AV patients whose severity is determined by the global acne score rate (GAS). Methods: Thiol parameters and IMA values were measured spectrophotometrically in blood samples taken from patients and controls. Determine VAS values in AV patients. The thiol and IMA values obtained were compared between the patient and control groups and their correlation with the patient's VAS values was evaluated. Results: In our study, in acne patients, native thiol (NT), total thiol (TT) and index 3 (I3=NT/TT*100) were significantly lower than the control group, disulfide (SS), index 1 (I1=SS/NT*100), index 2 (I2=SS/TT*100) and IMA values were found to be significantly higher. GAS values, which are accepted as an indicator of the degree and severity of acne disease, and SS, I1 and I2 showed a positive correlation, while I3 showed a negative correlation. Conclusion: Our study suggests that oxidative stress associated with AV disease pathogenesis may occur through mechanisms dependent on thiol and IMA levels. Therefore, in AV, oral supplementation or topical application of antioxidants may be a good way to increase drug efficacy or prevent potential harm.
PubDate: Tue, 31 Oct 2023 00:00:00 +000
- Clinical and Dermatoscopic Features of Seborrheic Keratoses According to
Skin Types: A Retrospective Study
Authors: Sadia Ammad; Gaetano Licata, Gabriella Brancaccio, Elvira Moscarella, Giuseppe Argenziano
Abstract: Introduction: Seborrheic keratoses (SK), are very common benign skin lesions, which may increase in number and size with age. Objective: The aim of the study was to assess any differences seen in seborrheic keratoses in relation to different skin types (ST) and lesion location. Methods: This was a retrospective observational study of 10-months period, based on dermoscopic images of seborrheic keratoses and patient history recorded in database. Patients were categorized according to their age, sex, skin type, and location of SK. Results: The frequency of SK remained high on the back for skin type 1, 2, 3 and 4. This same trend was also seen on the face and chest. In skin type 3 we saw a reversal of distribution of SK, the highest frequency remained on the back, and this was followed by the chest rather than the face. In skin type 5 and 6, the nature of the distribution of SK was more facial, Conclusions: In summary our study shows that SK are more commonly seen in males than in females, they tend to dominate in sun exposed sites especially the back and the face. Both the smaller and larger sized SK dominated in ST 1 and 2. The lighter to darker shades of colour seen in seborrheic keratoses varied in accordance with the skin type, with lighter coloured SK being seen more in lighter skin types as compared to darker skin types, whereas bluish coloured SK were seen in all skin types except ST 1.
PubDate: Tue, 31 Oct 2023 00:00:00 +000
- A Cross-Sectional Study on Post-Coronavirus Disease (COVID-19) Hair Loss
at a Tertiary Care Hospital
Authors: Dhaarna Wadhwa; Avneet Monga, Neha Kumar, Geeti Khullar, Sanchita Karmakar, Niti Khunger
Abstract: Background: Severe acute respiratory virus syndrome coronavirus 2 (SARS-CoV-2) was responsible for coronavirus disease (COVID-19) pandemic. As patients recovered from COVID-19 infection, hair loss was increasingly observed as a distressing symptom. Methods: This was a prospective cross-sectional study of patients with post COVID-19 hair loss between July to December 2021 at a tertiary care centre. Detailed history, clinical examination, trichoscopy and biochemical tests were performed and recorded. COVID-19 disease severity was assessed based on duration of COVID-19 infection and place of management. Results: The study included 120 patients with mean age being 39.6 years. Majority of the patients were females, treated at home and had COVID-19 infection for >2 weeks. Mean visual analog scale (VAS) score for stress was 5.25. Vitamin D deficiency was present in 56.7% and low ferritin in 30% of cases. Mean time of onset of hair loss post COVID-19 was 49 days. Patients mainly presented with diffuse hair loss. Trichodynia was present in 15.8% of cases. The degree of hair loss was severe in 55.8% of the subjects. Positive hair pull test was seen in 65% of patients. Most common trichoscopic features included single hair follicles’ (81.7%) and vellus hair >10% (60%). Conclusions: The mean time of onset of hair loss post COVID-19 infection was less than 2 months. Majority patients had diffuse pattern and severe degree of hair loss. Trichoscopy can aid in unmasking co-existing patterned hair loss in patients presenting clinically with diffuse hair loss.
PubDate: Tue, 31 Oct 2023 00:00:00 +000
- Effectiveness and Safety After a Switch to Tildrakizumab: A Real World
Multicenter Italian Study in Psoriasis
Authors: Eugenia Veronica Di Brizzi; Dario Buononato, Pierfrancesco Benvenuto, Giuseppe Argenziano, Rocco De Pasquale, Carmen Silvia Fiorella, Claudia Gioffrè, Maria Letizia Musumeci, Giovanni Palazzo, Leonardo Zichichi, Anna Balato
Abstract: Introduction: Tildrakizumab is a humanized IgG1κ monoclonal antibody targeting the p19 subunit of interleukin (IL)-23, approved in 2018 for the treatment of patients with moderate-to-severe chronic plaque psoriasis. Objectives: This study aimed to evaluate the effectiveness, safety and survival of tildrakizumab in the medium term (48 weeks) in psoriatic patients failure to previous biologic treatment in a real world setting. Methods: This was a retrospective, multicenter observational study that included adult patients with moderate-to-severe plaque psoriasis, failure to previous biologic therapy, consecutively treated with tildrakizumab. PASI and BSA values were recorded at baseline, at 12 and 48 weeks of treatment. Safety and tolerability of tildrakizumab were investigated by examining the presence of any adverse events. Results: Overall 51 patients were enrolled. Baseline disease severity was moderate to severe with a mean PASI score of 19.2 ± 8.5, mean BSA of 16 ± 10.4, and mean DLQI of 18.2 ± 6.8. A significant reduction in the mean PASI score was detected at 12 weeks of tildrakizumab therapy (3.5 ± 2.7, p < 0.001), with a further improvement at week 48 (0.6 ± 1.5, p < 0.001). At week 12, there was a great improvement in BSA score for all groups (p <0.001) with further increase at week 48. The effectiveness was confirmed also by DLQI assessment, with a significant decrease at week 12 and even more at week 48 (p <0.001). Conclusions: This study confirms the effectiveness of tildrakizumab in daily clinical practice in patients with moderate-to-severe plaque psoriasis.
PubDate: Tue, 31 Oct 2023 00:00:00 +000
- Cytokine Profiles of Chronic Urticaria Patients and the Effects of
Omalizumab Treatment
Authors: Ozge Can Bostan; Ebru Damadoglu, Basak Ezgi Sarac, Busra Kilic, Ümit Murat Sahiner, Cagatay Karaaslan, Gul Karakaya, Ali Fuat Kalyoncu
Abstract: Introduction: Cytokines are key mediators in immunological and inflammatory conditions, including chronic spontaneous urticaria (CSU). Objectives: To investigate Th1, Th2, and Th17 cytokine profiles in CSU and to evaluate the possible effect of omalizumab treatment. Methods: Patients who were followed up for CSU, as well as healthy volunteers, were included in the study. To assess urticaria activity, the 7-day-Urticaria Activity Score (UAS-7), the Urticaria Control Test (UCT), and the Chronic Urticaria Quality of Life Questionnaire (CU-QoL) were filled. Serum levels of IL-6, IL-17, IL-31, eotaxin, RANTES, TNF-α, and TSLP were analyzed by ELISA and compared in CSU and control groups. The patients were analyzed in two groups as the omalizumab group and the non-omalizumab group based on their treatment status. Results: Total IgE, ESR, CRP, RANTES, and TNF-a were significantly different in the overall comparison of the three groups: CSU-receiving omalizumab, CSU-not receiving omalizumab, and control groups (P <0.01, 0.015, <0.01, <0.01 and <0.01 respectively). Total IgE, CRP, RANTES, and TNF-α values were similar in those who received and did not receive omalizumab, yet these biomarkers were significantly higher in both groups than in the control group (P < 0.05). Statistical significance in ESR was observed only between the CSU-receiving omalizumab group and the control group (P = 0.01). Within the CSU patients, there was a slight but significant correlation between UCT and TNF-α (P = 0.008, r = 0.32) and IL-17 (P = 0.06, r = 0.33) levels. Conclusions: The investigated cytokine profile in CSU patients may differ from healthy controls, particularly with the higher levels of RANTES and TNF-α, and omalizumab treatment does not seem to affect that profile in CSU patients.
PubDate: Tue, 31 Oct 2023 00:00:00 +000
- Treatment Indications of Carbon Solution-Assisted Nd:YAG Laser According
to Patient Satisfaction: A Retrospective Study
Authors: Hüray Hügül; Defne Özkoca, Murat Kirişçi, Zekayi Kutlubay
Abstract: Background: Carbon solution-assisted Nd:YAG lasers were previously used in enlarged pores; hair removal; acne and acne scars; and facial rejuvenation. Objective:The aim of this study is to determine the patient satisfaction for different treatment indications of carbon solution-assisted 1064 nm Nd:YAG lasers. Patients and Method: This is a retrospective study that included the patients who were treated with carbon solution-assisted 1064 nm Nd:YAG laser with any indication in a private dermatology practice. A pre-prepared carbon solution was applied 30 minutes before the laser treatment with the following parameters: a spot size of 8mm, fluence of 1.3 J/cm2 and a frequency of 8Hz. Patient satisfaction was assesed with GAIS. Results: A total of 272 patients were included; of these 70 patients had acne lesions, 135 patients had melasma, 27 patients had post-inflammatory hyperpigmentation, 17 patients had ephelides and 23 patients had solar lentigines. The mean patient satisfaction for solar lentigo patients (4.35/5) was greater than for that of acne patients (4.26/5) which was greater than that of ephelide patients (3.94/5) which was greater than that of melasma patients (3.67/5) which was greater than that of post inflammatory hyperpigmentation patients (2.30/5) Conclusion: This study revealed that carbon solution-assisted 1064 nm Nd:YAG laser therapy is effective in the treatment of solar lentigo, acne vulgaris, ephelides and melasma. However, it fails to provide therapeutic efficacy in post inlammatory hyperpigmentation.
PubDate: Tue, 31 Oct 2023 00:00:00 +000
- Monitoring of Vitiligo Patches Over 6 Months to Validate Dermoscopic
Findings of Lesional Stability
Authors: Chitra Kamath; Rachita Dhurat, Bhavika Shah, Richa Sharma, Priyanka Arun Kowe, Sachin Chamle
Abstract: Background: Previously laid down criteria for lesional stability of vitiligo are inconsistent. Longitudinal data on correlation between dermoscopic features of vitiligo and disease activity is limited. Objective: To sequentially determine the dermoscopic features of vitiligo and to assess their association with the dynamic nature of the vitiligo patch. Methods: Sixty patients with 200 vitiligo patches fulfilling the inclusion criteria on medical therapy were subjected to sequential clinical and dermoscopic examination for 6 months. Baseline lesional photographs, dermoscopy and tracing of the patch was made and repeated at 6 months. The follow up tracing was superimposed onto the baseline tracing. Based on the increase or decrease in size, their outcomes were grouped as responsive, progressive and quiescent. Paired analysis of dermoscopic features was done between baseline, and their follow up after 6 months. Results: Well defined border was associated with static nature of the vitiligo patch and ill-defined borders and trichrome pattern depicted its dynamic nature. Statistically significant increase in leukotrichia and satellite lesions amongst progressive patches and a decrease amongst responsive patches was observed. Pigment network changes were statistically significant for both responsive and progressive patches. Satellite lesions and micro-Koebner’s phenomena was suggestive of progressive disease, while perifollicular pigmentation and perilesional hyperpigmentation was suggestive of repigmenting disease and proved to be an early marker for response to therapy. Conclusions: Repeated dermoscopic evaluation of lesions in a serial manner to assess disease activity helps understand their evolving nature and is a valuable tool in planning appropriate further treatment.
PubDate: Tue, 31 Oct 2023 00:00:00 +000
- Dermoscopy in the Diagnosis of Mycosis Fungoides: Can it Help'
Authors: Sarah Soliman; Wafaa Mohammad Ramadan, Amal Ahmed Elashmawy , Sameh Sarsik , Aimilios Lallas
Abstract: Introduction: The diagnosis of mycosis fungoides (MF) is challenging since it can mimic a variety of benign skin conditions. Multiple biopsies for histopathologic and immunohistochemical examination are required to diagnose MF. Dermoscopy is an affordable, non-invasive device with expanding indi-cations in dermatology, Objectives: To investigate the dermoscopic morphology of MF variants and assess the correlation between dermoscopic criteria, histopathologic, and immunohistochemical findings, Methods: We included 88 patients with several MF variants (classic, hypopigmented, hyperpigment-ed, poikilodermatous, erythrodermic, and folliculotropic).The diagnosis was histopathologically and immunohistochemically confirmed. Dermoscopic findings were collected, statistically analyzed, and correlated with the results of histopathology and immunohistochemistry, Results: All patients had MF diagnosis in H&E-stained sections.The majority revealed positive stain-ing with CD3, 4, 8 and negative CD7. Orange-red areas of discoloration, short linear, and spermato-zoa like blood vessels are the most frequent dermoscopic findings, while an analysis per MF variant was also performed.The frequently observed dermoscopic structures in classic MF were patchy whit-ish scales, dotted, short linear vessels, and spermatozoa-like vessels, Conclusions: Dermoscopy reveals a repetitive dermoscopic pattern in MF (non-homogenous pink to erythematous background, patchy areas of orange discoloration, patchy whitish scales, dotted and short linear blood vessels with some variations according to the clinical variant.
PubDate: Tue, 31 Oct 2023 00:00:00 +000
- Cutaneous Malignant Melanoma in Chile: Differences in Tumor Thickness and
Overall Survival Between Patients From Public and Private Health Care
Centers
Authors: Guisella Martínez; Francisco Bobadilla, Francisca Kinzel, Javier Fernández, Ivo Sazunic, María Magdalena Delgado, Laura Segovia, Andrea Zamudio, Nadia Vega
Abstract: Introduction: A low socioeconomic status (SES) is associated with lower survival rates in cutaneous malignant melanoma (CMM). In South America, there are few studies that analyze CMM data according to SES. Objectives: To determine the differences in microstaging and overall survival in CMM between public and private health care centers. Methods: Retrospective cohort study. Histopathological reports with a diagnosis of CMM from two public hospitals (PuH) and one private health care center (PrH) in Santiago from 2008 to 2018 were included. Patients’ death certificates were obtained to estimate overall survival. Results: 1014 MMC were found. The mean age was 58.6 ± 16.8 years and 59.9% corresponded to female patients. Of these, 33.9% received treatment at PuH and 66.1% at PrH. Patients from PuH had an increased risk of having an invasive CMM and a >1 mm thickness melanoma compared to PrH (OR 2.77 and 6.06, respectively). Patients with invasive CMM from the PuH were 6.29-fold more likely to die than a patient from the PrH. Conclusions: We observed a great disparity in tumor thickness between the socioeconomic sectors, reflecting a later detection and lower survival rate in PuH. Our results highlight a gap on which National Public Health should focus.
PubDate: Tue, 31 Oct 2023 00:00:00 +000
- Age-Related Macular Degeneration in Patients with Androgenetic Alopecia:
Could the Monocyte/HDL Ratio Be the Link'
Authors: Ghada Shams; Ahmed Abdel-Wahab Saleh, Ahmed Mohamed Saeed, Safa Nabil El-Damaty, Amira Osama Abdel-Ghaffar
Abstract: Introduction: Both Androgenetic alopecia (AGA) and age-related macular degeneration (AMD) shared the microinflammatory milieu and increased oxidative stress as important criteria in pathogenesis. Objectives: To assess the monocyte/High density lipoprotein (HDL) ratio (MHR) in patients with AGA and its correlation to AMD in these patients, if any. Methods: 40 patients with AGA aged 40 years or more of both sexes and 40 control subjects participated in this case-control study. General, dermatological, and ophthalmologic examination, MHR evaluation and optical coherence tomography (OCT) were performed. Results: The mean MHR was significantly higher in AGA patients (6.98 ± 2.21) than controls (3.82 ± 0.68) (p<0.001). AMD was significantly higher in patients than control (p <0.001). 80% of patients were diagnosed with AMD vs 20% of control subjects. Presence of AMD in AGA was significantly related to the degree of severity of AGA in male patients (P= 0.02). MHR was significantly higher in AGA patients found to have AMD (9.37 ± 1.1 and 7.01 ± 1.42 in wet and dry type respectively) than those without AMD (P<0.001). The best cutoff value of MHR in prediction of wet type among patients of AGA is ≥8.2337 with overall accuracy 80%. While the best cutoff value of MHR in prediction of dry type among AGA patients is ≥4.1408 to <8.2337 with overall accuracy 86.7%. Conclusion: AMD may develop more frequently in those with AGA, and this may correspond with the disease's severity. MHR seems to be a missing link between both conditions.
PubDate: Tue, 31 Oct 2023 00:00:00 +000
- Factors Affecting Topical Treatment Success in Pediatric Scabies Cases: A
Cross-Sectional Study
Authors: Muazzez Çiğdem Oba; Defne Özkoca, Rana Başara Şahin, Didem Şenses Kazan, Gaye Guldiken, Beril Kara Esen
Abstract: Introduction: Scabies is a common disease affecting the pediatric population. Treatment failure and relapses are frequent. Objectives: We aimed to define factors affecting topical treatment success in pediatric scabies patients. Methods: This multicenter cross-sectional study was performed between April and December 2022. Pediatric scabies cases were classified as treatment failure (TF) versus treatment success (TS). Results: We enrolled 170 patients in the study. In the TF group, the presence of symptomatic household members and referral from physicians other than dermatologists were more common (both p<0,001) and relapse rates and total symptom duration were higher (p=0,007, p<0,001 respectively). Permethrin 5% was more commonly used in the TF group (71.1% versus 25%) (p<0,001); however, the ratio of patients treated with sulfur preparations was significantly higher in the TS group (60.7% vs 16.9%) (p<0,001). Misapplication of topical therapy was significantly more common in the TF group (p<0,001), statistically significant errors being: (i) lack of treatment of close contacts (p<0,001); (ii) single application (p<0,001); and (iii) local application (p=0,027). In a multivariate analysis, treatment success was mainly associated with (i) presence of atopy (O.R.: 5,29, 95% CI: 1,22-25,57) ;(ii) absence of symptomatic household members (O.R.: 5,29, 95% CI: 1,72-16,27); (iii) presentation to dermatologists rather than other specialties (O.R.: 6,08, 95% CI: 1,9-19,51); whereas use of permethrin negatively affected treatment success (O.R: 0,22, 95% CI: 0,07-0,71). Conclusions: Pediatric scabies patients should be treated before other family members get affected and with topicals other than permethrin. Awareness of scabies disease needs to be increased among non-dermatologists.
PubDate: Tue, 31 Oct 2023 00:00:00 +000
- Melanoma Overdiagnosis: Historical Perspective and the Path Forward
Authors: Ashfaq A. Marghoob
PubDate: Tue, 31 Oct 2023 00:00:00 +000
- Overdiagnosis, Overtreatment or Oversurveillance of Melanoma: Is There a
Way Out'
Authors: Iris Zalaudek
PubDate: Tue, 31 Oct 2023 00:00:00 +000
- Overdiagnosis in Melanoma Screening: Is it a Real Problem'
Authors: Brigid Betz-Stablein; H. Peter Soyer
PubDate: Tue, 31 Oct 2023 00:00:00 +000
- How to Combat Overdiagnosis of Melanoma
Authors: Harald Kittler
PubDate: Tue, 31 Oct 2023 00:00:00 +000
- Overdiagnosis of Melanoma: Is it a Real Problem'
Authors: Cristian Navarrete-Dechent; Aimilios Lallas
PubDate: Tue, 31 Oct 2023 00:00:00 +000
- Efficacy and Adverse Effects of Corticosteroid Pulse Therapy in Alopecia
Areata
Authors: Fatemeh Rastaghi; Roxana Kaveh, Nazafarin Yazdanpanah, Akram-Sadat Sahaf, Najmeh Ahramiyanpour
Abstract: Introduction: Alopecia areata (AA) is a non-scarring, autoimmune hair loss disorder, varying in severity from small round hairless patches to the total loss of scalp or body hair. Steroid pulse therapy outcomes for AA vary. Objective: This study aimed to review the related literature regarding the efficacy, relapse rates, side effects, and prognostic factors associated with the response to different pulse corticosteroid treatments. Methods: The terms "pulse steroid therapy AND alopecia areata" and "pulse corticosteroid therapy AND alopecia areata" were searched on PubMed and Google Scholar. Results: A total of 24 articles were assessed. There was no difference in outcomes and side effects between intravenous and oral pulse corticosteroid therapy. The relapse rate and efficacy depended on the time of AA onset, age, and type: improved outcomes and decreased relapse were linked with recent onset (<6 months), younger age (<10 years), and the multifocal type. Patients with a past medical history of atopy, nail pitting, or thyroid disease and those with severe forms of AA, like alopecia totalis and alopecia universalis, had the least improvement. Conclusion: Pulse corticosteroids effectively induce hair regrowth in AA. Betamethasone seems to be the most effective agent (followed by intramuscular triamcinolone), especially in severe cases, but more side effects may accompany it. Combining this agent with other medications can reduce the dosage and side effects. Pulses of prednisolone and methylprednisolone are less effective but safer, as they have low relapse rates and adverse effects. A combination of them with other drugs can increase their efficacy.
PubDate: Tue, 31 Oct 2023 00:00:00 +000
- Publication trends and hot topics in dysplastic nevus research: A 30-year
bibliometric analysis
Authors: Hazal İzol Özmen
Abstract: Introduction: Dysplastic nevi are pigmented lesions that share clinical and histological features of both common nevi and melanoma. In recent years, there has been an increase in publications on dysplastic nevi. Bibliometric analysis is a method of evaluating trends in large number of publications and identifying popular topics. Objectives: The objective of this study is to provide an overview of the landscape of publications related to dysplastic nevi, visualize trends and popular topics in the literature. Methods: Scopus database was searched for the following terms in title, abstract or keywords: “dysplastic nevus” OR “dysplastic nevi”. Time span was set to 2002-2022. Document type was set to Article and Review. Data was obtained in RIS format from Scopus. Titles, authors, abstracts, institutions, countries, journals, references, and the citation information were recorded. Results: A network of 53422 references cited by 1559 publications was established. 1303 were articles and 256 were reviews. The number of publications increased 1.5 times from 2002 to 2022. Most studies were published from the USA 641 (41.2%) with Italy 171 (10,9%) and Australia 119 (7,6%) following. Keyword burst analysis was performed and melanoma related keywords seem to be more dominant in the recent decade. Author and reference co-citation analysis of were also performed. Conclusions: The amount of publications and citations generated about dysplastic nevi are increasing rapidly. This study demonstrates that there has been a shift in dysplastic nevi research in the last decade by focusing more on diagnostic methods and dysplastic nevi-melanoma relationship.
PubDate: Tue, 31 Oct 2023 00:00:00 +000
- Novel Vehicles For Drug Delivery In Atopic Dermatitis: A Narrative Review
Authors: Christopher Farkouh; Michelle Anthony, Parsa Abdi, Natalia Santiago, Matthew Farkouh
Abstract: Introduction: Atopic dermatitis (AD) causes dry and itchy skin and inflammation that severely impairs the quality of life of affected children and adults. While topical glucocorticosteroid application is typically the first-line treatment of choice, steroid treatment is associated with side effects and, increasingly, patient concerns about prolonged use. Novel drugs and drug delivery vehicles are required for patients with AD. Objective: To summarize the current literature on novel topical agents for atopic dermatitis and novel delivery vehicles. Methods: A literature search was conducted, and a narrative review was compiled to summarize recent evidence. Results: Novel topical drugs approved or in late-phase clinical trials for the treatment of AD include the Janus kinase inhibitor ruxolitinib, the phosphodiesterase-4 inhibitors crisaborole, and roflumilast, and the aryl hydrocarbon receptor activator tapinarof. While current topical drugs for AD are delivered via creams, ointments, gels, and related vehicles, novel delivery approaches such as electrospun patches, sprays, liposomes, nanoparticles, and lasers are being developed to enhance transdermal delivery, reduce side effects, and increase treatment adherence. Conclusion: Topical application of creams or ointments is currently the predominant vehicle for the delivery of atopic dermatitis drugs. In vitro studies on novel vehicles show promising results to overcome the issues associated with topical delivery. Still, these findings have to be corroborated by controlled studies with human patients in the future.
PubDate: Tue, 31 Oct 2023 00:00:00 +000
- The Use of 2D: 4D Digit Ratio as a Predictor of Androgenetic Alopecia: A
Review
Authors: Mohammed Almashali; Khalid Alekrish, Asem Shadid
Abstract: Androgenetic alopecia (AGA) is a common hair loss condition that impacts both men and women. Age and genetic susceptibility are recognized as potential risk factors for developing AGA. The second to fourth digit ratio is a measurement of the length ratios between the index and ring fingers. This ratio has been utilized as a predictor for multiple hyperandrogenism-related medical conditions. More recently, the 2D:4D ratio was investigated as a predictor for AGA. This article will examine the evidence supporting this relationship, discuss its diagnostic implications, and identify potential areas for future research.
PubDate: Tue, 31 Oct 2023 00:00:00 +000
- Patterns of Recurrence of Cutaneous Melanoma: A Literature Review
Authors: Dominga Peirano; Francisca Donoso, Sebastian Vargas, Leonel Hidalgo, Rosario Agüero, Pablo Uribe, Sebastian Mondaca, Cristian Patricio Navarrete-Dechent
Abstract: The incidence of melanoma has been dramatically increasing over the last decades. Melanoma is considered to have a high metastatic potential and it can progress due to hematogenous metastasis or via lymphatic vessels. Different patterns of recurrence have been described, namely, local, satellite, and in transit metastasis (LCIT), lymphatic, and systemic metastasis. With a more advanced melanoma stage at diagnosis, there is a higher risk for systemic metastasis in comparison to LCIT; in contrast, early-stage melanoma tends to recur more frequently as LCIT and less commonly as systematic metastasis. The aim of this review was to summarize the patterns of recurrence of cutaneous melanoma, giving the clinician a practical summary for diagnosis, prognosis, and surveillance. There is a knowledge gap of the common patterns of recurrence that needs to be addressed to better identify patients at high risk of disease recurrence and personalize surveillance strategies as well as patient counseling.
PubDate: Tue, 31 Oct 2023 00:00:00 +000
- Advanced Cutaneous Squamous Cell Carcinoma Management in Immunotherapy
Era: Achievements and New Challenges
Authors: Luigi Lorini; Andrea Alberti, Paolo Bossi
Abstract: Introduction of immunotherapy has radically changed the therapeutic scenario in patients affected by locally advanced and/or metastatic cutaneous squamous cell carcinoma patients. If it is well consolidated the role of immunotherapy in the setting of a disease not amenable to curative surgery and/or radiation, how to integrate immune checkpoint inhibitors in the curative setting is still under evaluation. Surgery combined or not with adjuvant radiotherapy remains the mainstay of curative treatment in localized cutaneous squamous cell carcinoma; however, promising data with neoadjuvant or perioperative immunotherapy could pave the way towards a treatment de-escalation according to the response achieved. On the other side, data on adjuvant treatment with pembrolizumab and cemiplimab after surgery and radiation are still awaited. Several questions related to the activity and safety of immunotherapy in real world setting still remain without answer, and several points need to be better explored. In the current review we will explore the updated literature on the use of immunotherapy in cutaneous squamous cell carcinoma, and we will show the current challenges in its use.
PubDate: Tue, 31 Oct 2023 00:00:00 +000
- Atopic Dermatitis in Individuals of Asian and African Ancestry: A Scoping
Systematic Review
Authors: Chiedu Ufodiama; Blessing Fabowale-Makinde, Christine Kleyn
Abstract: Introduction: Atopic Dermatitis (AD) affects individuals from all ethnicities and backgrounds. It has the highest global disease burden of dermatoses. There is a widely held belief that the presentation of AD is not described well in individuals with non-European ancestry in peer-reviewed literature. However, to our knowledge, this has not been investigated previously Objective: To quantify the number of peer-reviewed literature describing the appearance of clinical features of AD in non-European ancestry, particularly those originating from the Asian and African continents. Methods: A systematic scoping review between December 2020 and January 2021 was performed to quantify the number of studies describing AD in individuals of African and Asian ancestry. Reuslts: Sixteen studies were identified. None of the studies provided a clear description of AD in our population groups. Two studies described features of lichen planus like-AD in African American individuals. All studies reported on observed clinical features of AD. Conclusions: The review confirmed a lack of literature describing AD in populations of non-European heritage. It should encourage authors to make a deliberate effort to describe the appearance of clinical features of AD to enable understanding of how they may differentiate in individuals originating from different parts of the globe.
PubDate: Tue, 31 Oct 2023 00:00:00 +000
- Immunotherapy and Its Timing in Advanced Basal Cell Carcinoma Treatment
Authors: Clio Dessinioti; Alexander Stratigos
Abstract: For patients with advanced BCC, including locally advanced or metastatic BCC not amenable to curative surgery or radiotherapy, hedgehog pathway inhibitors (HHI) vismodegib and sonidegib are approved as first-line systemic treatment. Results from clinical trials highlight that the overall discontinuation rate of HHI treatment varies from 88% to 92% with vismodegib and is approximately 92% with sonidegib, and half of patients will discontinue HHI after approximately 8 to 12 months. The main factors weighing in on the decision to discontinue HHI, include efficacy (tumor response), adverse events and patient decision. In clinical practice, some of the patients that stop HHI may be re-evaluated if the tumor becomes amenable to surgery, or restart HHI at a later time, while others will need to switch to immunotherapy, depending on the reasons for HHI discontinuation. In this review, we revisit the therapeutic decisions considering a switch from HHI to immunotherapy with anti-PD-1 agent cemiplimab and we highlight the place of cemiplimab in the therapeutic ladder for patients with advanced BCC. We discuss the evidence on the efficacy and safety of anti-PD-1 agents as second-line systemic monotherapy, or in combination with other treatments, and the emergence of checkpoint immunotherapy as a neoadjuvant treatment.
PubDate: Tue, 31 Oct 2023 00:00:00 +000
- Functional Foods in Dermatology
Authors: Emily Strouphauer; Milbrey Parke, Ariadna Perez-Sanchez, Evelyne Tantry, Rajani Katta
Abstract: Functional foods, or whole foods that provide health benefits beyond their nutritional value, may provide multiple dermatological benefits. Research studies have documented benefits ranging from enhanced skin barrier function to improved wound healing, radiance, photoprotection, and hormonal regulation. Although the majority of research to date has involved small-scale human interventions or animal models, promising findings have been noted. In this review, we discuss the potential dermatological role of functional foods in hopes of advocating for larger-scale, evidence-based, human studies to expand this promising field.
PubDate: Tue, 31 Oct 2023 00:00:00 +000
- Photodynamic Therapy for Field Cancerization in the Skin: Where Do We
Stand'
Authors: Aikaterini Bakirtzi; Ilias Papadimitriou, Efstratios Vakirlis, Aimilios Lallas, Eleni Sotiriou
Abstract: Introduction: Photodynamic therapy (PDT) with a photosensitizer is available for the treatment of multiple actinic keratoses (AKs) in a restricted skin area or, as it is established, for the field-cancerized skin. Objectives: Our review aims to present the up-to-date literature on skin field cancerization using PDT employing different topical photosensitizers, modified light delivery protocols and combination treatments to obtain excellent efficacy and safety in everyday clinical practice. Methods: We sought PubMed, MEDLINE, Scopus, OVID, Embase, Science Direct, Cochrane Library, Research Gate and Google Scholar for [(aminolevulinic acid OR aminolevulinate) AND photodynamic therapy] with (field-directed OR field cancerization, (actinic keratosis), and (efficacy OR effectiveness OR pain OR tolerability) for studies published until February 2023. Results: Advantages of PDT compared to the other field treatments, including imiquimod, 5-fluorouracil, ingenol mebutate gel and diclofenac, reported better cosmetic outcomes and greater patient satisfaction. On the other hand, some drawbacks of field PDT include pain and treatment duration. Alternate illumination methods have also been investigated, including daylight as a light source. Pretreating the affected area may enhance photosensitizer absorption leading to better therapeutic results, while combinational treatments have also been tested. Patients prefer daylight PDT to traditional light sources since it is more well-tolerated and equally effective. Even as a preventive treatment, field PDT yields promising outcomes, especially for high-risk individuals, including organ transplant recipients. Conclusion: This review provides a thorough display of the field of PDT on cancerized skin, which will facilitate physicians in applying PDT more efficiently and intuitively.
PubDate: Tue, 31 Oct 2023 00:00:00 +000
- Repair of Defects of the Nasal Tip After Mohs Surgery
Authors: Sasia Pedersen; John Paoli, Robert Gniadecki, Martin Glud
Abstract: Introduction: Mohs Micrographic Surgery (MMS) is a treatment option for high-risk facial nonmelanoma skin cancer with high cure rates. Especially on the nasal tip, the tissue sparing properties of MMS are appealing. The nasal tip is a common location of nonmelanoma skin cancer and can be a challenging anatomical structure for reconstructive surgery due to its prominent location in the face, the shortage of spare tissue, as well as the stiffness and composition of different skin types, cartilage and bone. Objectives: The aim of the present paper is to review and demonstrate how reconstruction of the nasal tip can be done successfully to improve the care for patients undergoing MMS in this area. Methods: Using selected literature on the area and the surgeons experience, each method of repair are described including their individual advantages and challenges. Pictures and consent were selected from one patient who underwent each repair method and three photos are presented in this paper: one after tumor resection, one immediately after repair, and one minimum 6 months post-surgery. Results: We present eight surgical methods as well as pictures from previous surgeries. Conclusions: The results demonstrate obtainable results using very different surgical methods and the importance of an individualized approach to repairing cutaneous defects of the nasal tip.
PubDate: Tue, 31 Oct 2023 00:00:00 +000
- Dermatoscopic Patterns in Vitiligo
Authors: Juan Alberto Godínez-Chaparro; Rodrigo Roldán-Marín, Helena Vidaurri-de la Cruz, Luis Adrián Soto-Mota, Karen Férez
Abstract: Vitiligo is a chronic, acquired autoimmune pigmentary skin disease, most times it can be diagnosed clinically. Dermoscopy can confirm vitiligo in a non-invasive way. It is a diagnostic technique that visualizes sub-macroscopic morphological structures which correspond with specific histological structures. It detects subtle changes in the pigment pattern, evaluates vitiligo’s activity, attempts of repigmentation, leucotrichia, and differentiates it from other hypo pigmentary disorders. Most dermatoscopic clues used to assess vitiligo’s activity are found at the perifollicular level in the center and edge of the lesion. Perifollicular pigmentation is present in both active lesions and treated pigmented lesions with treatment. However, perifollicular depigmentation represents poor response, in treated lesions, and poor prognosis in untreated ones. The center of the lesion has reduced and/or absent pigment network, in active and stable lesions. If on dermoscopy the center of the lesion shows islands of pigment, erythema, or telagiectasias, repigmentation is suggested. At the periphery of the lesion, unstable vitiligo usually shows up as a diffuse border, trichrome pattern, micro-koebner/comet tail phenomenon, satellite lesions, or a tapioca sago pattern. In stable lesions it is more frequent to find clear borders and trichromes. Pigmented lesions commonly present sharp borders and marginal or perilesional hyperpigmentation.
PubDate: Tue, 31 Oct 2023 00:00:00 +000
- Yet Another Reason to Examine the Nails: Substantial Cancer-Related Worry
and Anxiety in Patients with Melanonychia in a Survey-Based Study
Authors: Jose W. Ricardo; Shari R Lipner
PubDate: Tue, 31 Oct 2023 00:00:00 +000
- Step for the Further Introduction of Teledermatology to Daily Practice in
Rural and Underserved Areas
Authors: Kazuhiko Kotani
PubDate: Tue, 31 Oct 2023 00:00:00 +000
- Merkel Cell Carcinoma: Mind The Genital Metastatic Sites!
Authors: Giacomo Santandrea; Stefania Borsari, Angelina Filice, Simonetta Piana
PubDate: Tue, 31 Oct 2023 00:00:00 +000
- Non-invasive Imaging Techniques for the Diagnosis of Clear Cell
Acanthomas: Dermoscopy, Reflectance Confocal Microscopy and Line-Field
Confocal Optical Coherence Tomography
Authors: Giulio Cortonesi; Carolina Donelli, Pietro Rubegni, Clelia Miracco, Elisa Cinotti
PubDate: Tue, 31 Oct 2023 00:00:00 +000
- Lichenoid Pseudovesicular Papular Eruption on the Nose With Dermoscopic
Features: A Case Series
Authors: Isha Gupta; Lovleen Kaur, Aanchal Bansal, Surabhi Dayal, Sanjay Kumar
PubDate: Tue, 31 Oct 2023 00:00:00 +000
- M2 Polarization May Contribute to Formation of Granulomatous Dermatitis in
Progression of Myelodysplastic Syndrome to Acute Myeloid Leukemia
Authors: Wei-Cheng Fang; Jeng-Shiun Du, Yue-Chiu Su, Li-Wen Chiu, Ting-Ting Yang
PubDate: Tue, 31 Oct 2023 00:00:00 +000
- Hidradenitis Suppurativa and Risk of Myocardial Infarction: A Plausible
Association'
Authors: Husein Husein-ElAhmed; Martin Steinhoff
PubDate: Tue, 31 Oct 2023 00:00:00 +000
- Clinicopathological Characteristics of Bowen Disease: A 7-year Study at a
Referral Dermatology Hospital
Authors: Seyed Mohammad Vahabi ; Mohammad Sadegh Dehghan Nasiri , Farzad Esmaeili Tarki , Hamidreza Mahmoudi , Maryam Daneshpazhooh , Ifa Etesami
PubDate: Tue, 31 Oct 2023 00:00:00 +000
- Syringocystadenoma Papilliferum of Eyelid, an Unusual Presentation: A Case
Series.
Authors: Omar Loza-Escutia ; Juan Alberto Godínez-Chaparro, Rosa María Guevara-Castillo, Marissa de Jesús Quintal-Ramírez, Elizabeth Natalia Quispe Susara
PubDate: Tue, 31 Oct 2023 00:00:00 +000
- Keratosis Lichenoides Chronica (Nekam Disease): Dermoscopic and in Vivo
Reflectance Confocal Microscopy Findings
Authors: Ayris Ozturk; Ayda Acar, Banu Yaman, Isil Karaarslan
PubDate: Tue, 31 Oct 2023 00:00:00 +000
- An Aggressive Case Of Infundibulocystic Squamous Cell Carcinoma On The
Upper Lip: A Hybrid Pathology Of Well-Differentiated And Infiltrative
Variants
Authors: Takumi Hasegawa; Shiro Iino, Shiori Sekine, Kohei Kitakaze, Natsuki Baba, Noritaka Oyama, Minoru Hasegawa
PubDate: Tue, 31 Oct 2023 00:00:00 +000
- Folliculitis Decalvans With Frontal Fibrosing Alopecia in a Dark
Phototype: Presentation of Folliculitis Decalvans and Lichen Planopilaris
Phenotypic Spectrum
Authors: Basma Karrakchou; Amani Fliti, Amal El Fiboumi, Fouad Kettani, Karima Senouci, Mariame Meziane
PubDate: Tue, 31 Oct 2023 00:00:00 +000
- Dermoscopy Reveals Pseudopitting of the Nail in Psoriasis
Authors: Ahu Yorulmaz
PubDate: Tue, 31 Oct 2023 00:00:00 +000
- An Atypical Presentation of Primary Cutaneous CD4+ Small/Medium
Pleomorphic T-Cell Lymphoproliferative Disorder
Authors: Didem Kazan; Dilek Bayramgürler, Eruyar Ahmet Tuğrul, Cüyan Demirkesen
PubDate: Tue, 31 Oct 2023 00:00:00 +000
- Successful Management of Periungual Acral Lentiginous Melanoma Using
Secondary Intention Healing
Authors: Min Jae Kim; Je-Ho Mun
PubDate: Tue, 31 Oct 2023 00:00:00 +000
- Papular Granuloma Annulare Mimicking Viral Warts
Authors: Carlotta Gurioli; Cosimo Misciali, Silvia Robuffo, Carlotta Baraldi, Lindsay Brooke Boling, Bianca Maria Piraccini
PubDate: Tue, 31 Oct 2023 00:00:00 +000
- Vitiligo Repigmentation After SARS-CoV-2 Vaccine
Authors: Roberto Bustos-Macaya; Francisco González-Coloma, Juan Pablo Morales Etcheberry, Laura Segovia
PubDate: Tue, 31 Oct 2023 00:00:00 +000
- Widespread Pruriginous Lesions with Flagellate Scarring
Authors: He Fu; Cheng Tan
PubDate: Tue, 31 Oct 2023 00:00:00 +000
- A Rare Genetic Disorder With Dermatologic Manifestation
Authors: Didem Kazan; Hatice Eloğlu, Rebiay Kiran
PubDate: Tue, 31 Oct 2023 00:00:00 +000
- Monkeypox Infection Mimicking Oral Primary Syphilis
Authors: Jorge Naharro-Rodríguez; Gerald Selda-Enríquez, Emilio García-Mouronte, Luis Alfonso Pérez-González, Ileana Teresa Dianzo-Delgado, Pablo Fernández-González
PubDate: Tue, 31 Oct 2023 00:00:00 +000
- Sudden-Onset Pain in Fibrous Hamartoma of Infancy in a Child: An Atypical
Presentation
Authors: Prabin P Dev ; Prashant Verma, Shruti Sharma, Niti Khunger
PubDate: Tue, 31 Oct 2023 00:00:00 +000
- Nail Lichen Striatus Affecting Adjacent Nails: A Sign of Blaschko Lines
Authors: Laura Gnesotto; Guido Mioso, Michela Starace, Bianca Maria Piraccini, Luigi Naldi , Andrea Sechi
PubDate: Tue, 31 Oct 2023 00:00:00 +000
- “Snail-Track Ulcers” And Macroglossia Due to Secondary
Syphilis
Authors: Alba Navarro-Bielsa; Tamara Gracia-Cazaña, Yolanda Gilaberte
PubDate: Tue, 31 Oct 2023 00:00:00 +000
- Trichoscopy Unmasks Tinea Capitis in Elderly Individuals
Authors: Theodosia Gkentsidi; Chryssoula Papageorgiou, Konstantinos Lallas, Aimilios Lallas, Zoe Apalla
PubDate: Tue, 31 Oct 2023 00:00:00 +000
- Eccrine Angiomatous Nevus With Verrucous Hemangioma-like Characteristics:
A Rare Case
Authors: Prabin P Dev ; Niti Khunger
PubDate: Tue, 31 Oct 2023 00:00:00 +000
- Familial BASCULE Syndrome In Two Siblings
Authors: Belén Romero Jiménez; Catalina Axpe-Gil, Jorge Román-Sainz, Fernando Gruber-Velasco, Marcela Martínez-Pérez, Adrian Imbernon-Moya
PubDate: Tue, 31 Oct 2023 00:00:00 +000
- Hyperpigmentation Induced by Hydroxychloroquine
Authors: Laila Hamri
PubDate: Tue, 31 Oct 2023 00:00:00 +000
- Hemorrhagic Blister in an Infant
Authors: Iria Neri; Luca Rapparini, Francesco Paolo Salamone, Miriam Leuzzi, Carlotta Gurioli, Bianca Maria Piraccini
PubDate: Tue, 31 Oct 2023 00:00:00 +000
- Photodynamic Therapy for Primary Cutaneous Extramammary Paget Disease
Authors: Alberto Meneguzzo; Roberto Mazzetto, Annalisa Lazzarotto, Stefano Piaserico
PubDate: Tue, 31 Oct 2023 00:00:00 +000
- Abscopal Effect After Localized Radiotherapy in a Patient With Sezary
Syndrome Under Treatment with Mogamulizumab
Authors: Vieri Grandi; Isabella Ciardetti, Andrea Gemignani, Eleonora Gherardi, Tommaso Grassi, Nicola Pimpinelli
PubDate: Tue, 31 Oct 2023 00:00:00 +000
- Adult Burn Inpatients Have Increased Burn Severity and Mortality Compared
to Children in a Retrospective Analysis of the 2017 National Inpatient
Sample 2017
Authors: Amar Desai; Noelle Desir, Shari Lipner
Abstract: Introduction: Socioeconomic status and comorbidities are associated with increased mortality in external surface burn patients of all ages, however differences in the impact of demographics between pediatric and adult burn populations has not been adequately studied. Objective: The purpose of this article is to explore the presentation, management, and outcomes of external surface burns between different age groups. Methods: The 2017 National Inpatient Sample (NIS) was queried for patients with any diagnosis of external body surface burns. Demographics, comorbidities, complications, total charges, length of stay (LOS), number of procedures undergone (NPU), and time from admission to first procedure (TFP) were identified. Univariate and multivariable analyses were used to identify statistical associations with age. Results: 52,335 inpatients were identified with burns, with the majority male (63.6%) and adults (81.8%). Mean age was 50.5 (SE: 0.1) and 5.5 (SE: 0.1) years for adults and children, respectively. Adults had higher incidence of hypertensive disease (43.5% vs. 1.4%), diabetes mellitus (24.1% vs. 0.3%), and obesity (11.7% vs. 1.6%) than children (p<0.001). Adults vs. children had higher odds for mortality (OR 4.26, 95% CI 3.08–5.89), sepsis (OR 5.16, 95% CI 4.10–6.48), and pneumonia (OR 4.26, 95% CI 3.30–5.50). Conclusion: In a national cohort of inpatients with external surface burns, total charges, LOS, NPU, TFP, and odds for complications varied by age. Pediatric patients more often had lower household incomes; however, adults had significantly higher odds for mortality suggesting that age and comorbidity status are more impactful on burn outcomes than socioeconomic status.
PubDate: Tue, 31 Oct 2023 00:00:00 +000
- Seven Plus One Steps to Assess Pigmented Nail Bands (Melanonychia Striata
Longitudinalis)
Authors: Aimilios Lallas; Katarzyna Korecka, Zoe Apalla, Dimitrios Sgouros, Konstantinos Liopyris, Giuseppe Argenziano, Luc Thomas
Abstract: Melanonychia striata longitudinalis might involve one or more fingers and/or toes and might result from several different causes, including benign and malignant tumors, trauma, infections, and acti-vation of melanocytes that might be reactive or related to the pigmentary trait,drugs and some rare syndromes.This broad differential diagnosis renders the clinical assessment of melanonychia striata particularly challenging. Nail matrix melanoma is relatively rare, occurs almost always in adults in-volves more frequently the first toe or thumb.The most common nail unit cancer,squamous cell carcinoma / Bowen disease (SCC) of the nail matrix is seldom pigmented. Histopathologic examina-tion remains the gold standard for melanoma and SCC diagnosis,but excisional or partial biopsies from the nail matrix require training and is not routinely performed by the majority of clinicians.Furthermore, the histopathologic evaluation of melanocytic lesions of the nail matrix is particularly challenging, since early melanoma has only bland histopathologic alterations. Dermatoscopy of the nail plate and its free edge significantly improves the clinical diagnosis, since specific patterns have been associated to each one of the causes of melanonychia. Based on knowledge generated and pub-lished in the last decades, we propose herein a stepwise diagnostic approach for melanonychia striata longitudinalis: 1) Hemorrhage first 2) Age matters 3) Number of nails matters 4) Free edge matters 5) Brown or gray' 6) Size matters 7) Regular or irregular and, finally,“follow back”.
PubDate: Tue, 31 Oct 2023 00:00:00 +000
- Combating Misinformation in Dermatology
Authors: Emelie Nelson; T. Austin Black, Morgan Rousseau, Rashid Rashid
PubDate: Tue, 31 Oct 2023 00:00:00 +000
