Publisher: Mattioli 1885 srl (Total: 9 journals)   [Sort by number of followers]

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Acta Bio Medica     Open Access   (Followers: 1, SJR: 0.224, CiteScore: 1)
Confinia Cephalalgica et Neurologica     Open Access  
Dermatology Practical & Conceptual     Open Access  
European J. of Oncology and Environmental Health     Open Access   (Followers: 8, SJR: 0.112, CiteScore: 0)
La Medicina del Lavoro     Partially Free   (Followers: 1, SJR: 0.299, CiteScore: 1)
Medicina Historica     Open Access  
Mediterranean J. of Hematology and Infectious Diseases     Open Access   (SJR: 0.506, CiteScore: 1)
Progress in Nutrition     Open Access   (Followers: 2, SJR: 0.193, CiteScore: 0)
Sarcoidosis Vasculitis and Diffuse Lung Diseases     Open Access   (Followers: 1, SJR: 0.765, CiteScore: 2)
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Dermatology Practical & Conceptual
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ISSN (Online) 2160-9381
Published by Mattioli 1885 srl Homepage  [9 journals]
  • Increased Prevalence of Bipolar Disorders in Hidradenitis Suppurativa:
           More Than a Striking Coexistence'

    • Authors: Pelin Esme; Aysenur Maden
      Abstract: Introduction: Hidradenitis suppurativa (HS) is a chronic inflammatory skin disorder of the hair follicle characterized by intense discharge and pain. Recently, HS's intrinsic association with neuropsychiatric disorders has become a focus of attention, and bipolar disorder (BD) emerged as a relevant topic for such an association. Objective: This study aimed to evaluate BD's prevalence among HS patients and present the HS and BD overlap patients' demographics, detailed clinical characteristics with a discussion on aggravating factors. Patients-Method: A retrospective chart review of 247 HS outpatients (Group-1) identified eight patients with BD. The frequency of BD in HS patients is compared to psoriasis patients (Group-2) and controls (Group-3) in age- and gender-matched groups. The demographic and clinical features of the 8 patients revealing HS-BD co-existence were analysed. Results: BD (n=9) was the 7th most common co-morbidity in the HS cohort. The frequency of BD is detected as 3.6% in group 1, 0.7% (n=1) in group 2, and 0.6% (n=1) in group 3, respectively. Group 1 demonstrated an increased prevalence of BD compared to other groups (p=0.001). Of the 8 patients revealing HS and BD co-existence, 75% were active smokers, 62.5% were obese and 50% had metabolic syndrome. Conclusion: This study's results reveal that the prevalence of BD in HS patients is higher than psoriasis patients and controls. The pathogenetic mechanisms underlying BD and HS co-existence needs to be investigated further.
      PubDate: Mon, 31 Oct 2022 00:00:00 +000
       
  • Patient Use of Complementary and Alternative Medicine for Psoriasis
           Vulgaris and Factors Believed to Trigger the Disease: A Multicenter
           Cross-Sectional Study with 1621 Patients

    • Authors: Melek Aslan Kayıran; Ayşe Serap Karadağ, İlteriş Oğuz Topal, Selma Emre, Esra Adışen, Sevilay Oğuz Kılıç, Nuray Keskin, Asude Kara Polat, Bengü Çevirgen Cemil, Mualla Polat, Oğuz Yılmaz, Hilal Ayvaz, Filiz Topaloğlu Demir, Sezgi Sarıkaya Solak, Derya Uçmak, Sema Aytekin, Mehmet Salih Gürel, Algün Polat Ekinci, Kübra Nursel Bölük, Neslihan Şendur, Tuğba Özkök Akbulut, Günseli Öztürk, Ayda Acar, Erkan Alpsoy
      Abstract: Background: Due to the chronic, recurrent nature of Psoriasis vulgaris (PV) and lack of definitive treatment for the disease, patients often resort to alternative treatments. Physicians seem to have low awareness of this issue. Objectives: To elicit the perceptions of 1,621 PV patients on complementary and alternative medicine (CAM) and examine factors reported to worsen PV. Methods: The patients’ sociodemographic characteristics, Psoriasis Area Severity Index (PASI), Dermatology Life Quality Index (DLQI), disease duration, and severity were recorded, and the patients’ CAM use was questioned in detail. The patients were also asked about factors that worsened PV and their experiences with a gluten-free diet. Results: Of the patients, 56.51% had used CAM. The mean age, illness duration, PASI score,s and DLQI of those using CAM were significantly higher. CAM use were significantly higher in those with facial, genital involvement, and arthralgia/arthritis. The patients mostly referred to CAM when PV became severe (46.4%). Of the CAM users, 45.52% used herbal topicals. The physicians of 67.03% did not inquire whether they used CAM. Of the participants, 37.73% considered that stress worsened their disease. Gluten-free diet did not affect PV symptoms in 52.22%. Conclusions: Patients’ CAM use is often overlooked by dermatologists. Our results showed that more than half the patients used CAM and did not share this information with their physicians. Therefore, the awareness of physicians should be increased and patients should be asked about the use of CAM and directed to the appropriate medical treatment options by physicians.
      PubDate: Mon, 31 Oct 2022 00:00:00 +000
       
  • Videodermoscopic changes of the hair in vitiligo lesions in relation to
           disease duration

    • Authors: Tag Anbar; Hamza Abdelraouf, Ahmed Abd Elfattah Afify, Maha Hussien Ragaie, Amira Abulfotooh Eid, Hoda Moneib
      Abstract: Introduction: Vitiligo is an acquired disease of complex pathogenesis, in which the immunologic attack to the skin and hair follicle melanocytes leads to areas of depigmentation and leukotrichia, respectively. Objectives: To study the dermoscopic features of the hair changes in vitiligo lesions in comparison to perilesional control areas and in relation to disease duration. Methods: Forty-seven patients with both old and recent vitiligo lesions were included. Dermoscopic features of hair within the lesions were examined and compared to those in perilesional non depigmented skin of the same patient. Results: Hair density (P < 0.001), terminal hair rate (P = 0.011), terminal to vellus hair ratio (P = 0.029) and mean hair shaft thickness (P = 0.031) were significantly decreased, whereas vellus hair rate (P = 0.011) was significantly increased in old vitiligo lesions compared to their respective control areas. The frequency of broken hair was significantly higher in old lesions (P < 0.001), while that of upright re-growing hair was significantly higher in recent lesions (P = 0.016). Conclusions: Hair involvement in vitiligo lesions is not only limited to the development of leukotrichia. Other subtle changes in hair density, anagen and telogen hair rates, and mean hair thickness can be detected. These changes may serve as objective clues to the duration of the lesions.
      PubDate: Mon, 31 Oct 2022 00:00:00 +000
       
  • Dermoscopy of linear basal cell carcinomas, a potential mimicker of linear
           lesions: a descriptive case series

    • Authors: Cristian Patricio Navarrete-Dechent; Michael Marchetti, Pablo Uribe, Rodrigo Schwartz, Konstantinos Liopyris, Nadeem Marghoob, Lucas Galimany, Juan Castro, Natalia Jaimes, Harold Rabinovitz, Ana Moraes, Ashfaq Marghoob, Alvaro Abarzua-Araya
      Abstract: Introduction: Among the various widely recognized basal cell carcinoma (BCC) clinical patterns, linear basal cell carcinoma (LBCC) is an uncommon morphologic variant of BCC. Objective: Describe the clinical and dermoscopic characteristics of LBCC. Methods: Retrospective study including LBCC cases from 5 dermatology centers in North and South America. Biopsy-proven primary BCCs, that presented with at least 3:1 length:width ratio on physical examination, irrespective of tumor subtype or location, were included. Clinical and dermoscopic analysis were performed by 2 experts in dermoscopy. Results: Eighteen cases of LBCC met our inclusion criteria and were included in the study. Median age at diagnosis was 86.0 years, 10 patients (58.8%) were males. Regarding anatomic location, 11/18 (61.1%) were located on the head and neck, 5/18 (27.7%) cases were found on the trunk, and 2 on lower extremities (11.1%). Under dermoscopy, 15/18 (83.3%) of LBCC were pigmented. All tumors displayed at least one of the BCC-specific dermoscopic criteria the most common being blue-grey globules (72.2%). Conclusions: Dermoscopy might be useful in the differentiation of LBCC from other diagnoses presenting as linear lesions such as scars, scratches/erosions, and tattoos, among others. Some of these lesions might be confused by naked eye examination alone.
      PubDate: Mon, 31 Oct 2022 00:00:00 +000
       
  • Granuloma annulare: a case-control study of possible associated diseases.

    • Authors: Rosa Fornons-Servent; Andrea Bauer-Alonso, Càudia Llobera-Ris, Rosa María Penín, Joaquim Marcoval
      Abstract: Introduction: Granuloma annulare (GA) has been reported as associated with multiple diseases, mainly diabetes mellitus (DM), thyroid diseases, and dyslipidemia. However, the high prevalence of some of these illnesses makes it difficult to assess whether the association is real or fortuitous. Our objective was to analyse the clinical features of our GA patients and the possible associations. Methods: This is a retrospective observational study of 225 patients with biopsy-proven GA diagnosed between 2009 and 2019 in a referral university hospital in Barcelona, Spain. Clinical charts were reviewed to obtain clinical data. As a control group we used a random list of 225 patients diagnosed in the hospital's traumatology department in the same period, matched by age and sex. Results: Diabetes was diagnosed in 40 GA patients (18%) (34 in the control group, 15%) and hypothyroidism in 33 (15%) (22 in the control group 9.8%); the differences were not significant. We also did not detect any association with uveitis, sarcoidosis, necrobiosis lipoidica, Sweet's syndrome, HIV infection, hepatitis B, or haematological malignancies. We only detected a possible association with hepatitis C (6 GA patients, 2.7%, versus 0 controls, p = 0.03), and hypercholesterolemia (108 GA patients, 48%, versus 79 controls, 35%, p = 0.007). Conclusions: The possible pathogenic explanations for the association with hepatitis C and hypercholesterolemia seem unlikely. We consider that the association of GA with other diseases, including hypercholesterolemia and hepatitis C, is doubtful and that it there is no justification rule out possible associated diseases in patients with GA.
      PubDate: Mon, 31 Oct 2022 00:00:00 +000
       
  • Evaluating the perception of Mycosis Fungoides patients about their
           disease before and after educating them

    • Authors: Maryam Nasimi; Robabeh Abedini, Yousef Fakour, Shideh Shahabi, Yasamin Kalantari, Ifa Etesami
      Abstract: BACKGROUND:Patient-held beliefs are important for disease management and few studies have evaluated illness perception of Mycosis Fungoides (MF) patients. Here, we aimed to determine the effect of educating MF patients on their perception of their disease. METHODS:Patients with diagnosed MF were asked to fill the Illness Perception Questionnaire-Revised (IPQ-R) once before education and once 3 months later. RESULTS:Fifty-five patients, 41 men and 14 women, with a mean age of 45.5 ± 13.9 years were enrolled. Regarding the main etiologic factor, most patients cited anxiety (91%). After education, the most significant changed belief on disease etiology was immune system dysfunction and the change was twenty-six percent which was observed more in patients with higher educational levels, shorter disease duration, and lower MF stages. Regarding the most prevalent clinical manifestations, the majority of patients mentioned erythema (86%). After education, the greatest change in symptom perception was related to lymphadenopathy (32%) which was significantly associated with less disease duration and those treated with phototherapy. Before education, the mean perception score about the disease chronicity was 23.67 ± 3.549 that increased to 27.71 ± 1.66 (p-value <0.001). This change was more observed in men (p-value=0.03), those with less disease duration, and those treated with phototherapy. CONCLUSION:Generally, MF patients hold favorable perspectives about their disease and educating them positively improves their illness perception. Patients with higher educational levels and lower stages of the disease showed more significant changes in various aspects of illness perception. Hence, early education is recommended in patients with lower educational levels.
      PubDate: Mon, 31 Oct 2022 00:00:00 +000
       
  • Omalizumab for the treatment of chronic spontaneous urticaria: association
           between body mass index and outcome

    • Authors: Irene Russo; Sara Cazzolla, Francesca Pampaloni, Mauro Alaibac
      Abstract: Introduction: Omalizumab has been recently registered as a third-line therapy for chronic spontaneous urticaria. Objectives: In this study, we aimed to provide real life data by reporting our experience with omalizumab in the treatment of chronic spontaneous urticaria. Methods: A retrospective data analysis was conducted on 40 patients affected by chronic spontaneous urticaria and treated with omalizumab at the Dermatology Unit of University of Padua, Italy.Demographic, anthropometric, and clinical data have been collected. Results: Overall, the majority of patients (23 patients, 57.5%) achieved complete recovery by taking omalizumab and 17.5% (7 patients) had a partial response. The majority of patients who did not have a response to omalizumab had a BMI> 25 kg/m2. Conclusions: Our study suggests that omalizumab is a safe and effective treatment for chronic spontaneous urticaria. We identified BMI as a critical biological factor that significantly impacts the outcomes of omalizumab treatment. Our findings also suggest a potential use of BMI as a predictive biomarker for omalizumab treatment. An updosing of omalizumab may be proposed in patients with high BMI to achieve a better control of the disease.
      PubDate: Mon, 31 Oct 2022 00:00:00 +000
       
  • Association between Atopic Dermatitis and Major Cardiovascular Outcomes: A
           Two-Sample Mendelian Randomization Study

    • Authors: Hongjiao Qi; Lifeng Wang, Linfeng Li
      Abstract: Background: Atopic dermatitis (AD) has been linked to cardiovascular disease (CVD) in population-based studies, however, their causal relationship is still unclear. Objective: To evaluate the causal association of AD with risk of cardiovascular outcomes using a Mendelian randomization (MR) approach. Method: We extracted summary-level data for AD, stroke, heart failure, coronary artery disease (CAD), myocardial infarction, angina pectoris from published, nonoverlapping genome-wide association studies (GWAS). Inverse variance weighted (IVW) method was used as the primary analysis. Alternative methods, including weighted median, MR Egger, MR-Pleiotropy Residual Sum and Outlier, weighted mode, and leave-out analysis, were performed to examine potential pleiotropy. Results: 13 SNPs (13,287 cases and 41,345 controls) were selected as instrumental variables (IVs). No associations of AD with risks of stroke [odds ratio (OR) = 1.03, 95%CI: 0.97-1.09, p = 0.3630], heart failure (OR = 1.04, 95%CI: 0.99-1.09, p= 0.119), coronary artery disease (OR = 1.00, 95%CI: 0.96-1.05, p= 0.988), myocardial infarction (OR = 1.00, 95%CI: 1.00-1.00, p= 0.322), and angina pectoris (OR = 1.00, 95%CI: 1.00-1.00, p= 0.369) was found. No significant effect of pleiotropy was detected. Conclusions: This MR study does not support a causal effect of AD on stroke, heart failure, CAD, myocardial infarction, angina pectoris.
      PubDate: Mon, 31 Oct 2022 00:00:00 +000
       
  • Dermoscopy of the diverse spectrum of cutaneous tuberculosis in the skin
           of color

    • Authors: Rashmi Jindal; Payal Chauhan, Sheenam Sethi
      Abstract: Introduction: Cutaneous tuberculosis is an uncommon form of tuberculosis, accounting for 1-2% of all forms of extra-pulmonary tuberculosis. Knowledge of the dermoscopy characteristics of different clinical types of cutaneous tuberculosis can help timely diagnosis resulting in better outcomes. Materials and methods: All clinically suspected and biopsy confirmed cases of cutaneous tuberculosis seen from July 2019 through December 2021 were retrospectively recruited. Information including age, gender, disease duration, site and morphology of lesions, and presence of concomitant tuberculosis elsewhere was noted. Two investigators retrospectively reviewed the dermoscopic characteristics of these cases. Results: Twenty-two patients comprised of 12 women and ten men met the inclusion criteria. Lupus vulgaris was the commonest presentation of cutaneous tuberculosis seen in 13 patients. Five had scrofuloderma, two had tuberculosis verrucosa cutis and one patient each had lichen scrofulosorum and papulo-necrotic tuberculid. Yellow-orange structureless areas (100%), linear/dot vessels (100%), white scales (92.3%), and white structureless areas (84.6%) were the predominant dermoscopy findings in lupus vulgaris. In scrofuloderma, linear vessels and white structureless areas were visible in all cases. Dirty white scales with a papillated surface were characteristically seen in tuberculosis verrucosa cutis, with one of the two patients each showing vessels and yellow-orange structureless areas. White globules with surrounding erythema were seen in lichen scrofulosorum and yellow-orange structureless areas with keratin plugs in papulo-necrotic tuberculid. Conclusion: A thorough understanding of the characteristic dermoscopy of cutaneous tuberculosis can help suspect the diagnosis early resulting in better management opportunity.
      PubDate: Mon, 31 Oct 2022 00:00:00 +000
       
  • The accuracy of clinical diagnosis in 2135 lesions on the face

    • Authors: Anna Czaplicka; Magdalena Misiak-Gałązka, Joanna Czuwara, Adam Gałązka, Barbara Górnicka, Lidia Rudnicka
      Abstract: Introduction: Biopsy of facial skin lesions is an important supplement to dermatological diagnostics, especially in doubtful cases or suspected of being malignant. Objectives: The aim of the retrospective study of 2135 histopathological records of lesions on the face was to: 1). establish the most common indications for a skin biopsy in patients with facial lesions, 2). establish the frequency of histopathological diagnoses, 3). evaluate how often clinically suspected inflammatory lesions are identified as tumors in histopathology, 4). evaluate the accuracy of clinical diagnoses of the most common skin tumors and dermatoses. Methods: It was a retrospective study. Histopathological records from the lesions on the face from years 2010-2017 were analyzed. Results: The mean age of patients was 69.3 [7-98]. 58.28% of the patients were women. Among 2135 clinical diagnoses skin tumors were suspected in 1905 cases. Among 2169 obtained histopathological results (34 biopsies showed two diseases), we identified skin tumors in 1940 cases, with 1388 confirmed as malignant. The clinical diagnosis of a specific benign or malignant skin tumor was accurate in 1013/1634 subjects, in comparison to inflammatory lesions, which were correct in 67/148 cases, (p=0.0001). Among all preliminary inflammatory diagnoses, 33/204 lesions were identified as skin tumors in histopathology. Conclusions:In conclusion in most cases of skin tumors the clinical diagnosis is confirmed by histopathological examination. In case of facial inflammatory lesions, the accuracy of clinical diagnosis is lower, with a significant number of facial lesions appearing inflammatory in clinical evaluation but being diagnosed as skin cancers in pathology.
      PubDate: Mon, 31 Oct 2022 00:00:00 +000
       
  • Indications for Digital Monitoring of Patients With Multiple Nevi:
           Recommendations from the International Dermoscopy Society

    • Authors: Teresa Russo; Vincenzo Piccolo, Elvira Moscarella, Philipp Tschandl, Harald Kittler, John Paoli, Aimilios Lallas, Ralph P Braun, Luc Thomas, H Peter Soyer, Josep Malvehy, Susana Puig, Ashfaq Marghoob, Alon Scope, Andreas Blum, Allan C Halpern, Horacio Cabo, Scott Menzies, Wilhem Stolz, Masaru Tanaka, Harold Rabinovitz, Rainer Hofmann-Wellenhof, Renato Marchiori Bakos, Iris Zalaudek, Giovanni Pellacani, Anna Varela Veiga, Laura Rosende Maceiras, Cristina de las Heras-Sotos, Giuseppe Argenziano
      Abstract: Introduction: In patients with multiple nevi, sequential imaging using total body skin photography (TBSP) coupled with digital dermoscopy (DD) documentation reduces unnecessary excisions and improves the early detection of melanoma. Correct patient selection is essential for optimizing the efficacy of this diagnostic approach. Objectives: The purpose of the study was to identify, via expert consensus, the best indications for TBSP and DD follow-up. Methods: This study was performed on behalf of the International Dermoscopy Society (IDS). We attained consensus by using an e-Delphi methodology. The panel of participants included international experts in dermoscopy. In each Delphi round, experts were asked to select from a list of indications for TBSP and DD. Results: Expert consensus was attained after 3 rounds of Delphi. Participants considered a total nevus count of 60 or more nevi or the presence of a CDKN2A mutation sufficient to refer the patient for digital monitoring. Patients with more than 40 nevi were only considered an indication in case of personal history of melanoma or red hair and/or a MC1R mutation or history of organ transplantation. Conclusions: Our recommendations support clinicians in choosing appropriate follow-up regimens for patients with multiple nevi and in applying the time-consuming procedure of sequential imaging more efficiently. Further studies and real-life data are needed to confirm the usefulness of this list of indications in clinical practice.
      PubDate: Mon, 31 Oct 2022 00:00:00 +000
       
  • Challenges for new adopters in pre-surgical margin assessment by handheld
           reflectance confocal microscope of basal cell carcinoma; a prospective
           single-center study

    • Authors: Nina Richarz; Aram Boada, Ane Jaka, Julio Bassas, Carlos Ferrandiz , Jose Manuel Carrascosa, Oriol Yélamos
      Abstract: Introduction: In vivo reflectance confocal microscopy (RCM) is a useful tool for assessing pre-surgical skin tumor margins when performed by a skilled, experienced user. The technique, however, poses significant challenges to novice users, particularly when a handheld RCM (HRCM) device is used. Objective: To evaluate the performance of an HRCM device operated by a novice user to delineate basal cell carcinoma (BCC) margins before Mohs micrographic surgery (MMS) Methods: We performed a prospective study of 17 consecutive patients with a BCC in a high-risk facial area (the H zone) in whom tumor margins were assessed by HRCM and dermoscopy before MMS. Predicted surgical defect areas (cm2) were calculated using standardized photographic digital documentation and compared to final defect areas after staged excision. Results: No significant differences were observed between median HRCM-predicted and observed surgical defect areas (2.95 cm2 [range: 0.83–17.52] vs 2.52 cm2 [range 0.71–14.42]; p=0.586). Dermoscopy, by contrast, produced significantly underestimated values (median area of 1.34 cm2 [0.41-4.64] vs 2.52 cm2 [range 0.71-14.42]; p<0.001). Confounders leading to poor agreement between predicted and observed areas were previous treatment (n=5), a purely infiltrative subtype (n=1), and abundant sebaceous hyperplasia (n=1). Conclusion: Even in the hands of a novice user, HRCM is more accurate than dermoscopy for delineating lateral BCCs margins in high-risk areas and performs well at predicting final surgical defects.
      PubDate: Mon, 31 Oct 2022 00:00:00 +000
       
  • Diagnostic Role of Direct Immunofluorescence Assay in Determining The
           Etiology of Erythroderma: Experience in a Tertiary Referral Hospital

    • Authors: Ecem Bostan; Ozay Gokoz, Sibel Dogan, Duygu Gulseren, Neslihan Akdogan, Basak Yalici-armagan, Sibel Ersoy-Evans, Gonca Elcin, Aysen Karaduman
      Abstract: Introduction: Erythroderma is a life-threatening dermatologic emergency which is characterized by diffuse erythema and exfoliation affecting more than 90% of the body surface area. Most common cutaneous diseases associated with erythroderma are systemic contact dermatitis, psoriasis, drug eruption and atopic dermatitis. Clinicopathological correlation is used to determine the underlying disease. In addition, direct immunoflurorescence (DIF) may provide significant clues for etiology of erythroderma especially in the case of autoimmune bullous skin diseases (ABSDs). Objectives: In our study, we aimed to analyze the demographic data, clinical prediagnoses, final diagnosis, histopathological and DIF examination findings, accompanying systemic signs and laboratory abnormalities of erythrodermic patients. Methods: We conducted a retrospective study of 31 erythroderma patients in a referral hospital between 2014 and 2021. Cutaneous biopsies were taken from all patients for Hematoxyin&Eosin and DIF examination. Results: Average age was 54. 6 ± 23 years. 48.4% of the patients were female (n=15) whereas 51.6 % of the patients were male (n=16). Average time between the onset of rash and biopsy was 18.8 days. DIF analysis showed immune deposits in 19.4% (n=6) of the patients; whereas no immune deposits were detected in 80.6% (n=25) of the patients. The most frequent final diagnosis was adverse cutaneous drug eruption followed by ABSDs. Conclusions: Our findings suggest that DIF may be used in conjunction with clinicopathologic and clinical findings to reveal the associated skin diseases in erythrodermic patients. Erythrodermic patients presenting with clinical findings of ABSD should be considered for DIF examination.
      PubDate: Mon, 31 Oct 2022 00:00:00 +000
       
  • Alterations of the human gut microbiome in patients with hidradenitis
           suppurativa: a case-control study and review of the literature

    • Authors: Neslihan Demirel Öğüt; Gülşen Hasçelik, Nilgün Atakan
      Abstract: Background: Hidradenitis suppurativa (HS) is a systemic inflammatory disease that extends beyond the skin. The role of gut microbiome alterations in the pathogenesis of inflammatory and autoimmune disorders is remarkable.Objective: Based on the hypothesis that dysbiosis in the gut microbiome may be a trigger for systemic inflammation in the pathogenesis of HS, the aim of this study was to investigate whether the gut microbiome is altered in HS patients comparing with healthy subjects.Methods: In present case-control study, fecal samples from 15 patients with HS and 15 age- and sex-matched healthy individuals were collected and analyzed using 16S rRNA-based metagenomic analysis. The V3 and V4-hypervariable regions of 16S rDNA gene were amplified from all samples and sequenced by the Illumina MiSeq platform. Bioinformatic analyzes were performed in QIIME2. Results: Shannon alpha diversity index showed significantly reduced diversity in HS patients (P = 0.048). Bray-Curtis Dissimilarity and Jaccard Distance revealed that the gut microbial composition of HS patients was significantly distinctive from that of controls (P = 0.01 and P = 0.007, respectively). The relative abundance of unclassified Clostridiales, unclassified Firmicutes and Fusicatenibacter in HS was significantly lower than that in controls (P = 0.005,  P = 0.029, and P = 0.046, respectively).Conclusion: This study indicated that significant alterations in gut microbiota of HS patients could play a critical role in the pathogenesis of HS and might be a trigger for systemic inflammation. Increased understanding the pathogenesis of HS will shed light on the new potential therapeutic targets and novel treatment options.
      PubDate: Mon, 31 Oct 2022 00:00:00 +000
       
  • Transepidermal Delivery of Triamcinolone Acetonide or Platelet Rich Plasma
           using either Fractional Carbon Dioxide Laser or Microneedling in Treatment
           of Alopecia Areata

    • Authors: Khaled El Mulla; Eman Elmorsy, Dalia Halwag, Eman Hassan
      Abstract: Introduction: Transepidermal drug delivery, using “laser-assisted drug delivery'', or microneedling, are new treatment modalities, that can improve drug penetration into skin in treatment of alopecia areata patients. Objective: To evaluate the use of fractional carbon dioxide laser versus microneedling in transepidermal delivery of triamcinolone acetonide and platelet rich plasma in alopecia areata treatment. Methods: Interventional comparative study carried out on 60 patients, randomly divided into four equal groups. Group I :Fractional Carbon dioxide laser and triamcinolone acetonide. Group II: Microneedling with Dermapen and triamcinolone acetonide. Group III: Fractional Carbon dioxide laser and Platelet-rich plasma. Group IV: Microneedling with Dermapen and Platelet-rich plasma. Patients were assessed clinically, using Severity of Alopecia Tool score and hair regrowth scale, and dermoscopically. Results: In all treatment groups, there was improvement in the Regrowth scale, with statistical significance between the different groups at fourth (p= 0.001*) and last (p= 0.008*) visits, with highest, most significant changes in Pen-Steroid group. Comparing Regrowth scale at last visit, results were in favor of dermapen, compared to Carbon dioxide laser for Transepidermal drug delivery (p=0.023*); and in favor of triamcinolone acetonide, compared to Platelet-rich plasma as topical medication (p=0.015*). Dermoscopic signs of improvement included decrease in black dots, and appearance of Upright regrowing hairs (p= <0.001*). Conclusion: Microneedling and fractional Carbon dioxide laser can be effectively used for transepidermal drug delivery for Alopecia areata treatment. Microneedling for delivery of Triamcinolone acetonide showed best treatment outcomes. Dermoscopy can be used in alopecia areata for evaluation of treatment response.
      PubDate: Mon, 31 Oct 2022 00:00:00 +000
       
  • Evaluation of Sleep Quality in Patients with Genital and Nongenital
           Cutaneous Warts: A prospective controlled study

    • Authors: Muge Gore Karaali; Vildan Manav
      Abstract: Introduction: Diseases affect sleep quality and the state of sleep quality may also affect the state of diseases by affecting the immune system. Depending on the immune status of the patients with cutaneous warts, the extent of the disease and the response to treatment may vary. Objectives: We aim characterize the association between cutaneous warts and sleep quality. Methods: A prospective controlled study was conducted. Patients over 18 years old with cutaneous wart were enrolled. Control subjects were age- and sex- matched healthy people. Demographic and clinical data of the participants were questioned. Sleep quality of participants was evaluated with Pitssburgh Sleep Quality Index (PSQI). Results: A total of 138 patients with cutaneous warts (genital (n=59), nongenital (n=79)) and 83 controls were interviewed. Patients with cutaneous warts showed significantly higher global PSQI score than the control group (warts vs control, 7.68±3.53 vs 4.92±2.91). The rate of having poor sleep quality in the patient group was higher than the individuals in the control group (Odds ratio (OR): 3.835). Patients with genital warts showed significantly higher global PSQI score than the patients with nongenital warts (genital vs nongenital, 8.61±3.63 vs 6.98±3.32). Female patients with genital warts showed significantly higher global PSQI score than male patients with genital warts. Conclusions: Evaluation of sleep quality in patients with warts, especially in patients with genital warts may be suggested. The management of sleep disturbances in cutaneous warts may help increase the quality of life of patients and may effect on disease control.
      PubDate: Mon, 31 Oct 2022 00:00:00 +000
       
  • Investigation on utility of some novel terpenes on transungual delivery of
           terbinafine for the management of onychomycosis

    • Authors: Isha Gupta; Syeda Nashvia Adin, Mohd Aqil, Mohd Mujeeb, Yasmin Sultana
      Abstract: Introduction: Onychomycosis is a fungal disorder of the nail which afflicts 5% of the population worldwide. The disease is strenuous to cure as it is chronic, hard to eliminate and tends to recur. Topical therapy is at the forefront for the treatment of many disorders of nail. However, the success rate of topical therapy has been halted owing to the poor permeation of topical therapeutics across densely keratinized nail barrier. Therefore, ungual drug permeation must be improved for an effective topical therapy. An approach to achieve this goal would be the use of terpenes from natural sources as potential penetration enhancers. This study is aimed to explore the effectiveness of some novel terpenes as potential penetration enhancers on transungual delivery of terbinafine. Methods: Ex-vivo permeation studies were performed by sopping the nail clippings of healthy human volunteers in control and working solutions containing terbinafine (5mg/ml) per se and terbinafine (5mg/ml) with 6% of each terpenes including lavandulol, safranal, rose oxide, limonene, 3-methyl-2-butene-1-ol, and linalool respectively for 48 hours. The terbinafine concentration in nail samples was determined using a HPLC method. Results: Statistical analysis showed that studied terpenes increase transungual penetration of terbinafine in the following order: linalool > rose oxide > 3-methyl-2-butene-1-ol > safranal> limonene>lavandulol acetate. Accordingly, linalool was found to be the most effective penetration enhancer for the transungual delivery of terbinafine. Conclusion: It is concluded that linalool can be used as safe and potential penetration enhancer for enhancing the transungual delivery of terbinafine for onychomycosis.
      PubDate: Mon, 31 Oct 2022 00:00:00 +000
       
  • Dermoscopy And Reflectance Confocal Microscopy To Estimate Breslow Index
           And Mitotic Rate In Primary Melanoma

    • Authors: Zamira Barragan-Estudillo; Johanna Brito, Marion Chavez-Bourgeois, Beatriz Alejo, Llucia Alos, Adriana Patricia García, Susana Puig, Josep Malvehy, Cristina Carrera
      Abstract: Introduction: Non-invasive imaging techniques offer the possibility to optimize the first approach to melanoma. RCM has a promising role in predicting the main prognostic events in the dermoepidermal and papillary dermis.   Objectives: To identify pre-surgical criteria that can predict the main prognostic features of melanoma.   Methods: A retrospective cohort-study evaluated dermoscopic, confocal and histopathological characteristics of consecutively diagnosed sporadic melanomas. RCM-melanoma patterns classified into 1) dendritic-cell, 2) round-cell, 3) dermal nest and 4) combined type. Acral, facial and mucosal locations were excluded.   Results: 92 primary melanomas were included: 44 male and 48 female (mean age 60.4 years, SD 16.2) with a mean Breslow of 1.43mm (SD 1.6). The most frequent dermoscopic presentation was the multicomponent pattern, the predominant confocal pattern was dendritic-cell type (44.6%). The presence of pigmented network on dermoscopy was related to lower Breslow and mitotic rates (both p=0.002); in contrast to the presence of visible vessels, which was related to higher Breslow and mitotic indexes (both p=0.001). Confocal observation of dermal nests or atypical cells in the papillary dermis was related to a higher mitotic rate (p=0.006 and p=0.03, respectively). Similarly, diffuse inflammatory infiltrates visible in the superficial dermis was associated with higher Breslow (p=0.04) and mitotic index (p=0.04).   Conclusions: Dermoscopic and RCM in vivo findings on primary melanoma correlate with histopathologic Breslow index, mitotic rate and tumor infiltrating lymphocytes. The architecture and cytology of primary melanoma can be estimated by combining dermoscopy and RCM prior to excision.
      PubDate: Mon, 31 Oct 2022 00:00:00 +000
       
  • Clinico-Epidemiological Aspects of Cutaneous Lesions in Injecting Drug
           Users Visiting an Oral Substitution Therapy Centre: A Cross-Sectional
           Study

    • Authors: Shaminder Singh Dhillon; Tejinder Kaur, Neeru Bala, none Mankaranpreet
      Abstract: Introduction: Drug abuse has been taking a great toll on the health and well-being of the community for the past few decades. Substance abuse can lead to several cutaneous manifestations both direct injury by the offending drug or the practices of drug usage causing secondary damage to the skin. The early recognition of these signs is of utmost importance to prevent long-term complications. Objectives: To study the clinical-epidemiological profile of the skin diseases in Injecting Drug Users (IDU) attending Oral Substitution Therapy (OST) center and assess the psychological impact of skin conditions in IDUs attending oral substitution therapy center. Methods: This cross-sectional observational study involved 100 IDUs enrolled from the OST center who were subjected to brief history taking and clinical and dermoscopic evaluation of skin lesions. Dermatological quality of life index (DLQI), Depression, Anxiety, Stress Scale (DASS), and WHO-QoL questionnaire were used to evaluate the impact of skin lesions on Psycho-social health and quality of life of IDUs. Results: Cutaneous lesions ranged from track marks to severe ulcerations and scarring. Mucosal lesions also took a toll on several Patients. Patients had varying degrees of anxiety, depression, and mental stress. Conclusions: Injecting Drug Abusers are prone to acquire Skin diseases due to injury caused by drugs as well as by drug practices adopted and the degree of neglect may worsen these conditions. These cutaneous lesions hamper the quality of life and cause psychosocial disturbances.
      PubDate: Mon, 31 Oct 2022 00:00:00 +000
       
  • Reflectance confocal microscopy follow-up of multifocal superficial basal
           cell carcinomas treated with imiquimod 5% cream

    • Authors: Yun-Min Zou; Xiaohong Zhu, Rushan Xia
      Abstract: Background: Patients with multifocal superficial basal cell carcinomas (sBCC) require a non-invasive treatment and follow-up with a non-invasive technique. Imiquimod 5% cream is a new non-invasive therapy for BCC. Reflectance confocal microscopy (RCM) is a non-invasive, real-time imaging technique. Methods:The efficacy of imiquimod 5% cream for the treatment of multifocal sBCC was evaluated, as well as the potential of RCM for assessing therapeutic effects. We reported four patients with 34 sBCC lesions were treated with imiquimod 5% cream. RCM was performed in the baseline and at 12 weeks, 24 weeks and 52 weeks after starting treatment. Results: Of 34 lesions treated with imiquimod 5%, 32 responded to the treatment and showed complete clinical clearing. Two subclinical BCC lesions were identified by RCM. The complete tumor clearance rate was 88.2%, and the efficiency rate was 97.1%. No lesion recurred at 24-month follow-up. RCM identified previously described confocal features of BCC and was more sensitive than clinical examination. Local skin reactions were relieved after expectant treatment. Conclusions: Imiquimod 5% cream may be useful for the treatment of multifocal sBCC, and its side effects are easy to manage. RCM can be used for non-invasive monitoring of treatment response and improved the tumor clearance rate.  
      PubDate: Mon, 31 Oct 2022 00:00:00 +000
       
  • COVID-19 Knowledge in Patients with Psoriasis Receiving Systemic Therapy:
           A Questionnaire Study

    • Authors: Sinan Özçelik; Fatma Arzu Kılıç
      Abstract: Introduction: Little is known about how much the impact of patient-driven issues on the treatment of psoriasis in the amid of COVID-19 pandemic. Objectives: We aimed to investigate the COVID-19 knowledge of the patients with psoriasis receiving systemic therapy in the pandemic. Methods: The patients who received systemic treatment for psoriasis presented to our dermatology outpatient clinic were enrolled in the study. A questionnaire measuring the level of knowledge about COVID-19 and psoriasis was administered to patients. Demographics and disease characteristics of patients were recorded. Results: A total of 183 patients with psoriasis were enrolled in the study. Of the patients, 33.9% thought that psoriasis exposes them to a risk of getting COVID-19, 30.6% declared that psoriasis treatment exposes them to a risk of getting COVID-19, and 59.6% were worried about getting COVID-19. The treatment discontinuation rate was 42.1%. The patients with high scholarity level showed more anxiety and discontinued their treatment. Conclusions: The patients with psoriasis did not have adequate knowledge of the effect of both psoriasis itself and its treatment on COVID-19 during the pandemic. The patients on biologic therapy tend to discontinue their treatment based upon the physician's recommendation, whereas those on conventional therapy mostly on their own will. Clinicians should provide patients with not only as much information as they need but also current evidence about both psoriasis and COVID-19.
      PubDate: Mon, 31 Oct 2022 00:00:00 +000
       
  • Adiponectin contributes to the inflammatory milieu in hidradenitis
           suppurativa

    • Authors: Ersilia Nigro; Rita Polito, Graziella Babino, Edi Mattera, Elisabetta Fulgione, Giovanni Ragozzino, Vittoria D'Esposito, Serena Cabaro, Giuseppe Signoriello, Pietro Formisano, Giuseppe Argenziano, Aurora Daniele
      Abstract: Introduction: Hidradenitis suppurativa (HS) is a severe chronic inflammatory skin disease. Although the pathogenesis remains unclear, at the basis of HS there is an enhancement of the immune and inflammatory response together with a susceptibility to environmental factors. Cytokines dysregulation is crucial in HS severity and progression. Objectives: the aim of this study was to analyze serum levels of different cytokines focusing on adiponectin concentration and its oligomeric distribution in serum from HS patients compared to both obese and healthy subjects. Methods: The concentrations of adiponectin and cytokines were measured using ELISA assay; the oligomeric distribution of adiponectin was evaluated through Western Blotting analysis. Results: Total Adiponectin is statistically higher in HS patients compared to matched controls (28.54 ±4.49μg/mL vs 24.67±3.35 μg/mL, p=0.00). Interestingly, Adiponectin oligomerization state is altered in HS, with an increase of HMW oligomers. Serum levels of PDGF-BB, IL-1b, IL-5, Il-6, IL12, IL13, IL15, IL-17, GMCSF, INFg, VEGF and MCP-1 are statistically higher while IL-1ra and RANTES levels are statistically lower in HS patients compared to healthy controls. Interestingly, adiponectin positively correlates with PDGF-BB, and IL-13. Conclusions: HS patients have a dysregulated immune homeostasis correlated with altered metabolism. Indeed, our data suggest that Adiponectin and its HMW oligomers are involved in HS representing a potential biomarker of disease. In particular, the specific correlation of adiponectin with PDGF-BB, and IL-13 extends its role in modulation of immune responses suggesting that this adipokine might act regulating the innate immune system rather that the adaptive one.
      PubDate: Mon, 31 Oct 2022 00:00:00 +000
       
  • Dermatopathological Correlation of Clinically Challenging Cutaneous
           Lesions: A Single Center Experience of 2184 cases

    • Authors: Yunus Ozcan; Emin Özlü, Ebru Karagün, Belkız Uyar, Mehmet Gamsızkan
      Abstract: Introduction: Although textbooks provide the ideal clinical and histopathological findings, in practice we usually have fewer, and sometimes contradictory, findings to work with.
      Objectives: The primary goal of this study is to categorize the diagnoses of clinically challenging skin lesions, thereby identifying the most common diagnostic scenarios encountered by dermatopathologists in practice and the most perplexing differential diagnoses submitted by clinicians. Our secondary aim is to investigate how the case profile and clinician decision-making processes changed during the COVID-19 pandemic.
      Methods: We classified 2184 pathology reports into four major categories: inflammatory, neoplastic, non-diagnostic, and other. In each category, the three most frequently reported diagnoses were listed. For each listed diagnosis, the top 3 most frequently used differential diagnoses by the clinician prior to biopsy are listed. The period one year after and before the first nationally reported COVID-19 case was compared using the same classification.
      Results: The most common diagnoses and clinical differential diagnoses were listed for each category, with 45.4% being inflammatory and 27.4% being neoplastic diseases. Non-diagnostic reports accounted for 11.4% of all reports. The overall number of reports has decreased drastically since the pandemic, and the rates of keratinocytic and melanocytic neoplasms have increased, while the rates of other malignancies and spongiotic diseases have decreased.
      Conclusion: Although a trained eye can easily identify skin lesions when they are typical, even diseases we are familiar with can present atypically in real life. In these cases, histopathological examinations and clinicopathological correlation are critical in making an accurate diagnosis.


      PubDate: Mon, 31 Oct 2022 00:00:00 +000
       
  • The Impact of Covid-19 Pandemic on Hidradenitis Suppurativa Patients: a
           Cross-Sectional Study From Tertiary Referral Hospital

    • Authors: Ecem Bostan; Adam Jarbou, Aysen Karaduman, Duygu Gulseren, Neslihan Akdogan, Basak Yalici-armagan
      Abstract: Introduction: Hidradenitis suppurativa (HS) is a chronic, disabling skin disorder which is characterized by recurrent attacks of nodule, abscess, sinus tract formation which eventually leads to significant scarring. Oral/topical antibiotics, oral retinoids and TNF-alpha inhibitors are used to control disease activity and improve symptoms.   Objective: In the present study, we aimed to determine the prevalance of COVID-19 real-time polymerase chain reaction (RT-PCR) positivity and Covid-19 related symptoms in relation to the age, gender, body mass index (BMI), disease duration, accompanying systemic diseases, treatment used for HS, treatment duration and smoking.   Methods: We conducted a comparative, cross-sectional study of 178 patients diagnosed with HS in a referral hospital. Age, gender, smoking status, BMI, treatment modalities used for HS, the presence of COVID-19 related symptoms, history of close contact to a person with COVID-19 and COVID-19 RT-PCR results were determined by a telephone questionnaire and checked from medical data records.   Results: Sixty-three patients were female, whereas 115 patients were male. During Covid-19 pandemic, 94 out of 178 patients had Covid-19 related symptoms; Covid-19 RT-PCR test was performed in 109 (61.2%) patients. Thirty (27.5%) cases tested positive for Covid-19 whereas 79 (72.5%) tested negative.   Conclusions: Patients having Covid-19 related symptoms were shown to have statistically significantly higher mean age compared to the ones who did not have any symptoms (p=0.031). No statistically significant relationship was found Covid-19 RT-PCR positivity and the type of treatment administered for HS when categorized as TNF-alpha inhibitor, oral retinoid, topical antibiotic and oral antibiotic group (p>0.05).
      PubDate: Mon, 31 Oct 2022 00:00:00 +000
       
  • UV Irradiation of Nevi: Impact on Performance of Electrical Impedance
           Spectroscopy and a Convolution Neural Network

    • Authors: Julia K. Winkler; Holger A. Haenssle, Lorenz Uhlmann, Anissa Schweizer-Rick, Christine Fink
      Abstract: Introduction: UV irradiation of nevi induces transient melanocytic activation with dermoscopic and histological changes. Objectives:We investigated whether UV irradiation of nevi may influence electrical impedance spectroscopy (EIS) or convolution neural networks (CNN). Methods: Prospective, controlled trial in 50 patients undergoing phototherapy (selective UV phototherapy (SUP), UVA1, SUP/UVA1, or PUVA). EIS (Nevisense, SciBase AB, Sweden) and CNN scores (Moleanalyzer-Pro, FotoFinder Systems, Germany) of nevi were assessed before (V1) and after UV irradiation (V2). One nevus (nevusirr) was exposed to UV light, another UV-shielded (nevusnon-irr). Results: There were no significant differences in EIS scores of nevusirr before (2.99 [2.51-3.47]) and after irradiation (3.32 [2.86-3.78]; p=0.163), which was on average 13.28 (range 4-47) days later. Similarly, UV-shielded nevusnon-irr did not show significant changes of EIS scores (V1: 2.65 [2.19-3.11]), V2: 2.92 [2.50-3.34]; p=0.094). Subgroup analysis by irradiation revealed a significant increase of EIS scores of nevusirr (V1: 2.69 [2.21-3.16], V2: 3.23 [2.72-3.73]; p=0.044) and nevusnon-irr (V1: 2.57 [2.07-3.07], V2: 3.03 [2.48-3.57]; p=0.033) for patients receiving SUP. In contrast, CNN scores of nevusirr (p=0.995) and nevusnon-irr (p=0.352) showed no significant differences before and after phototherapy. Conclusions: For the tested EIS system increased EIS scores were found in nevi exposed to SUP. In contrast, CNN results were more robust against UV exposure.
      PubDate: Mon, 31 Oct 2022 00:00:00 +000
       
  • The hunt for baby melanomas: a prospective study of the dermoscopy
           features on 100 small melanoma cases with in vivo surface diameters up to
           a maximum of 6mm.

    • Authors: John Pyne; Sarah MacDonald, Susan Beale, Esther Myint, Wei Huang, Simon Clark, Andrew Trang
      Abstract: Background:: Early diagnosis can improve melanoma prognosis. Dermoscopy can enhance early melanoma recognition. Objectives: Examine the dermoscopy features of early melanoma up to a maximum surface diameter of 6mm. Methods: Consecutive melanoma cases were collected from two medical practices in Sydney, Australia 2019-2021. Dermoscopy features were recorded for melanomas by maximum surface diameter, to the nearest 0.1 mm, to a limit of 6mm. Results: Total cases numbered 100; with males (n=48) and females (n=52), melanoma in situ (MIS, n=96) and invasive (n=4). The most frequent anatomic sites on both males and females were back (males n=20, females n=16) then knee or leg (males n=8, females n=12). Minimum respective MIS diameters for males/females was 1.2/2.0mm and for invasive cases 2.0/3.4mm. Highest frequency dermoscopy features were: light brown, dark brown, grey and asymmetric melanoma shape. Brown pigment in hair follicles were more frequent on legs compared to other anatomic sites [OR 14.6, 95%CI (1.29-165.17), p 0.03]. Pseudopods were substantially increased in frequency comparing diameters less than 4mm with 4 up to 6mm [OR 8.81, 95%CI (1.05-73.9), p 0.004]. Structureless area cases recorded increased grey [OR 7.08, 95%CI (1.61-31.11) p=0.01]. Melanomas with edge angulation were noted in 20-50% of cases across diameters 1-6mm, less frequent were pigmented circles and polygons. Conclusion: Watch out! MIS presented with a surface diameter of just 1.2 mm and invasive melanoma 2.5mm. Pseudopods were a strong clue to melanomas with a surface diameter less than 5mm. We found melanomas on leg sites displayed more frequent pigmented hair follicles.
      PubDate: Mon, 31 Oct 2022 00:00:00 +000
       
  • Papulopustular rosacea treated with ivermectin 1% cream: remission of the
           Demodex mite infestation over the time and evaluation of clinical relapses
           

    • Authors: Ilaria Trave; Claudia Micalizzi, Emanuele Cozzani, Giulia Gasparini, Aurora Parodi
      Abstract: Background: Topical ivermectin is an anti-inflammatory and anti-Demodex drug for papulopustular rosacea. Rosacea is a relapsing disease and the time between recurrences should be considered alongside efficacy Objectives: The aims of this study were to assess the time of first relapse and relapse rates of Demodex mite infestation and papulopustular rosacea Methods: We conducted a prospective study of subjects affected by different degrees of papulopustular rosacea. Patients that achieved a complete response after treatment were monitored every 4 weeks and up to 32 additional weeks. For each patient, we evaluated recording the time to first relapse and relapse rate of Demodex mite infestation and rosacea. Results: The overall success rate on Demodex infestation was 87.5%. only 12.5% relapse. Ivermectin leads to complete response in 70% of patients. Median time to relapse was 140 days, the mean time was 152 days. The global success rate was 54.76%. Conclusions: Topical ivermectin keeps a remission of Demodex infestation and clinical remission for long time. We proposed a twice-weekly ivermectin maintenance therapy to reduce recurrences.
      PubDate: Mon, 31 Oct 2022 00:00:00 +000
       
  • Dermoscopic differentiation of blister beetle dermatitis and herpes
           zoster: An observational study

    • Authors: Balachandra Suryakant Ankad; Varsha Koti, Aimilios Lallas
      Abstract: Introduction: Blister beetle dermatitis (BBD) and herpes zoster (HZ) manifest suddenly with vesicular lesions mimicking each other and progress rapidly. But a lack of definite differentiating criteria yearns the need for better investigating modality. Though histopathology persuades the need, is an invasive procedure, commonly deferred. Thus, dermoscopy a non-invasive rapid diagnostic tool, can help in differentiating. Objectives: To evaluate different dermoscopic patterns of BBD and HZ to differentiate both and to study dermoscopic features in early and late stages of lesions. Methods: An observational cross-section study conducted in southern India. Nine patients with clinical features suggestive of BBD and HZ were recruited. Lesions were divided arbitrarily into early and late. Dermoscopic examination was performed with handheld dermoscope. Diagnosis was confirmed by skin biopsy and Tzanck smear wherever necessary. Statistical analysis performed using data in terms of frequencies and percentages. Results: Dermoscopy of early BBD lesions showed multiple discrete and confluent yellowish-white structures, brown dots, roundish white globules, gray structures,  ‘targetoid pattern’, brown areas over intense reddish pink background. Late BBD lesions revealed pinkish-white area, reduced gray structures and, dotted and globular vessels. Early HZ lesions showed polylobular gray and brown globules, bright pink background, gray globules covered by grayish veil-like structure with gray rim. Late HZ lesions revealed ‘solar eclipse’ pattern and ‘crumpled fabric ‘patterns. The dermoscopic findings correlated with histopathology. Conclusions: Dermoscopic patterns show peculiar features consistently pertaining to BBD and HZ thus help in early diagnosis assisting in accurate treatment both conditions.
      PubDate: Mon, 31 Oct 2022 00:00:00 +000
       
  • Serum Copper and Zinc levels among Iranian vitiligo patients

    • Authors: Zahra Khoshdel; Naser Gholijani, Maryam Niknam, Nasim Rahmani, Mohsen Hemmati-Dinarvand, Fakhraddin Naghibalhossaini
      Abstract: Introduction: Vitiligo is a chronic skin disease, which its etiopathogenesis is not fully understood. Numerous studies have suggested that oxidative stress may play a role in the pathophysiology of vitiligo. There are controversial reports as to the changes of serum trace elements, copper and zinc levels in vitiligo patients. Objective: In this study, we evaluated the alterations in the level of serum Cu and Zn among a group of Iranian vitiligo patients. Methods: The levels of serum Cu and Zn were compared between 117 vitiligo patients and 137 healthy controls using atomic absorption spectrophotometry. Results: The mean Cu and Zn levels in the case group (113.57 ± 59.43 and 95.01 ± 58.95 μg/dl, respectively) were significantly lower than those of the control group (138.90 ± 38.14 and 121.83 ± 33.80 μg/dl, respectively) (p= 0.00). We also observed significantly lower serum Cu and Zn concentrations in young (<50 years) than the elderly (≥50 years) patients (p=0.00). The mean Cu and Zn levels in the patients with generalized vitiligo (111.63±54.18 and 93.11±59.33 μg/dl, respectively) were significantly lower than patients with localized vitiligo (120.74 ±71.64 and 98.69±58.63 μg/dl, respectively) and those in the control group (p = 0.00). The serum Cu/Zn ratio obtained in the young and male patients was higher than those in their matched control counterparts (p=0.01). Conclusions: The current study has shown that the disturbance of serum Cu and Zn levels is associated with vitiligo, and may play an important role in the disease development of Iranian vitiligo patients.
      PubDate: Mon, 31 Oct 2022 00:00:00 +000
       
  • Mycoplasma pneumoniae-associated subcorneal pustular dermatosis: not as
           rare as we think'

    • Authors: Gloria Baeza-Hernández; Alberto Guerrero-Torija, Ricardo Francisco Rubio-Aguilera, Radia Khedaoui, Cristina Martínez-Morán, Jesús Borbujo
      PubDate: Mon, 31 Oct 2022 00:00:00 +000
       
  • Clinicopathological and demographic characteristics of Paget disease: A
           4-year study showing a male predominance in extramammary paget

    • Authors: Kamran Balighi; Yasamin Kalantari, Kambiz Kamyab Hesari, Vahide Lajevardi, Hamidreza kheiri, Zeinab Aryanian
      PubDate: Mon, 31 Oct 2022 00:00:00 +000
       
  • Dermatoscopic features of angiomatoid spitz nevus: a case report

    • Authors: Belkiz Uyar; Ömer Faruk Elmas, Asuman Kilitçi
      Abstract: Angiomatoid Spitz nevus is an uncommon histopathological variant of Spitz nevus that is most frequently seen on the extremities of children and young adults. Dermatoscopic features of this unusual variant have rarely been reported. We presented a 19-year-old female diagnosed with angiomatoid Spitz nevus based on the clinical, dermatoscopic, and histopathological findings. Polarized-light dermatoscopic examination showed a red structureless background, white lines reticular, numerous coiled vessels without specific arrangement and surface scale. Although the dermatoscopic findings we described in this case can be observed in SN in general, we believe that the predominancy of coiled vessels may be an important clue to the angiomatoid variant of SN.
      PubDate: Mon, 31 Oct 2022 00:00:00 +000
       
  • Not all polarized-light dermatoscopes may display diagnostically critical
           polarizing-specific features

    • Authors: Chin Whybrew ; Pawel Pietkiewicz , Ihor Kohut, Justin C Chia, Bengu Nisa Akay, Cliff Rosendahl
      PubDate: Mon, 31 Oct 2022 00:00:00 +000
       
  • Recurrent microinvasive subungueal squamous cell carcinoma in an HIV
           patient: a case of good response to photodynamic therapy

    • Authors: Aurora Alessandrini; Valeria Evangelista, Alessia Barisani, Sabina Vaccari, Emi Dika, Bianca Maria Piraccini, Michela Starace
      PubDate: Mon, 31 Oct 2022 00:00:00 +000
       
  • Primary cutaneous follicle center B lymphoma at the site of a resolved
           herpes zoster eruption

    • Authors: Francesco Messina; Giulia Tadiotto Cicogna, Riccardo Rondinone, Mauro Alaibac
      PubDate: Mon, 31 Oct 2022 00:00:00 +000
       
  • Dermoscopy of lymphoplasmacellular erosive dermatitis of the scalp reveals
           striking similarities to lymphoplasmacellular balanitis of Zoon

    • Authors: Enrico Zelin; Claudio Conforti, Ludovica Toffoli, Nicola Di Meo, Diego Signoretto, Iris Zaludek
      Abstract: Not applicable
      PubDate: Mon, 31 Oct 2022 00:00:00 +000
       
  • Five synchronous melanomas: role of dermoscopy as a triage tool to manage
           melanoma during the COVID-19 pandemic

    • Authors: Carla Tubau; Lluís Rusiñol, Guillermo Sánchez-Rodríguez, Helena Iznerdo, Victoria Amat-Samaranch, Oriol Yélamos
      PubDate: Mon, 31 Oct 2022 00:00:00 +000
       
  • Dermatologic Manifestations of Thymoma-associated Multiorgan Autoimmunity
           (TAMA) Syndrome: Cutaneous Signs of an Immune Dysregulation

    • Authors: Luigi Rossiello; Amalia Lupoli, Giuseppe Cicala, Gianfranco De Dominicis, Vittorio Tancredi, Stefano Caccavale
      PubDate: Mon, 31 Oct 2022 00:00:00 +000
       
  • Dupilumab-associated facial erythema successfully treated with oral
           ivermectin

    • Authors: Javier Gil-Lianes; Daniel Morgado-Carrasco
      PubDate: Mon, 31 Oct 2022 00:00:00 +000
       
  • Patch testing in patients with alopecia areata: a case-series study

    • Authors: Eirini Kyrmanidou; Eleni Sotiriou, Demetrios Ioannides, Zoi Apalla, A Emvalomati, Elisavet Lazaridou
      PubDate: Mon, 31 Oct 2022 00:00:00 +000
       
  • Isolated patchy heterochromia with pili annulati features on light and
           electron microscopy

    • Authors: Alejandro Lobato-Berezo; David Pesqué, Ramon M Pujol
      PubDate: Mon, 31 Oct 2022 00:00:00 +000
       
  • Benefits and Pitfalls of Using In Vivo Reflectance Confocal Microscopy in
           Lentigo Maligna Diagnostics. Case Reports

    • Authors: Ieva Povilaite; Giuseppe Argenziano, Graziella Babino, Claudio Conforti, Elvira Moscarella, Francesca Pagliuca, Andrea Ronchi, Iris Zalaudek, Marina Agozzino
      PubDate: Mon, 31 Oct 2022 00:00:00 +000
       
  • Sexually transmitted infections during the COVID-19 pandemic in a Swedish
           healthcare region without lockdown: a focus on gonorrhoea and syphilis

    • Authors: Sandra Gulin-Jerkovic; Maria Pissa
      PubDate: Mon, 31 Oct 2022 00:00:00 +000
       
  • Application of machine learning technologies to improve the diagnostic
           value of dermatoscopy, combined with digital photo-fixation of skin
           neoplasms

    • Authors: Marian Voloshynovych; Galyna Girnyk, Valerii Chmut , Iryna Blaga, Nataliia Kozak
      PubDate: Mon, 31 Oct 2022 00:00:00 +000
       
  • Subcutaneous Granuloma Annulare in an Atypical Age Group in Immediate
           Post-COVID Phase

    • Authors: Lovleen Kaur; Disha Chakraborty, Surabhi Dayal, Sunita Singh, Karamvir Yadav
      PubDate: Mon, 31 Oct 2022 00:00:00 +000
       
  • Cobblestone-like skin

    • Authors: Laura Macca; Luca Di Bartolomeo, Claudio Guarneri
      PubDate: Mon, 31 Oct 2022 00:00:00 +000
       
  • Yellow urticaria

    • Authors: Teresa Maria Kränke; Birger Kränke
      PubDate: Mon, 31 Oct 2022 00:00:00 +000
       
  • Dermoscopy of diabetic dermopathy

    • Authors: Montserrat Navarro-Gilo; Nuria Alberti, Mercedes De Gea, Anna Domingo, Marc Sagristà
      PubDate: Mon, 31 Oct 2022 00:00:00 +000
       
  • Necrobiotic Xanthogranuloma as Sign of Monoclonal Gammopathy

    • Authors: Claudio Conforti; Iris Zalaudek
      PubDate: Mon, 31 Oct 2022 00:00:00 +000
       
  • Aneurysmal dermatofibroma after varicose vein surgery.

    • Authors: Pablo Villagrasa-Boli; Juan Monte-Serrano, Sara Martínez-Cisneros, Alejandro Martínez-García
      PubDate: Mon, 31 Oct 2022 00:00:00 +000
       
  • Subungual Eccrine Angiomatous Hamartoma: Description of a Novel
           Dermoscopic Feature

    • Authors: Takahiro Mizuta; Nobuo Isono, Miyuki Kato
      PubDate: Mon, 31 Oct 2022 00:00:00 +000
       
  • Atypical Spitz nevus: dermoscopic, confocal microscopic and
           histopathological correlation

    • Authors: Rita Bouceiro-Mendes; Camila Scharf, Eugenia Veronica Di Brizzi, Andrea Ronchi, Giuseppe Argenziano, Elvira Moscarella
      PubDate: Mon, 31 Oct 2022 00:00:00 +000
       
  • Dermoscopic changes in nevi during an atopic dermatitis flare-up.

    • Authors: Sara Pilar Herrero Ruiz; Anastasia Alejandra Garrido-Ríos, Helena Álvarez Garrido, Laura Fernández de la Fuente, Begoña Echeverría García, Jesús Borbujo Martínez
      PubDate: Mon, 31 Oct 2022 00:00:00 +000
       
  • Erythema multiforme: A clinico-dermoscopic-histopathological correlation
           of evolving targetoid lesions

    • Authors: Shreya Deoghare; Devayani Pol
      PubDate: Mon, 31 Oct 2022 00:00:00 +000
       
  • Dermoscopic findings of the evolving pigmented Spitz nevus in a child

    • Authors: Joanna Pogorzelska-Dyrbuś; Beata Bergler-Czop
      Abstract: According to the
      Authors Guidelines in case of image letters no abstract should be provided.
      PubDate: Mon, 31 Oct 2022 00:00:00 +000
       
  • Lichenoid keratosis simulating melanoma: A case report.

    • Authors: Leire Barrutia; Nelson Lobos, Josep Malvehy, Sebastian Podlipnik
      PubDate: Mon, 31 Oct 2022 00:00:00 +000
       
  • White rosettes as a new dermoscopic finding in acute cutaneous lupus
           erythematosus patient with unilateral erythema

    • Authors: Fangyan Zhou; Shisheng Chen
      PubDate: Mon, 31 Oct 2022 00:00:00 +000
       
  • Various Applications of Tofacitinib and Ruxolitinib (Janus Kinase
           Inhibitors) in Dermatology and Rheumatology: A Review of Current Evidence
           and Future Perspective

    • Authors: Sara Sadeghi; Azadeh Goodarzi
      Abstract: Backgrounds: Janus kinase inhibitors (JAKi) are anti-inflammatory medications suppressing Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway by inhibiting various cytokines receptors on the membrane of cells. Mutations and polymorphisms on JAK and STAT proteins can cause dysregulation in the balance of immune system, and ultimately result in autoimmune disorders. Objectives: to record and summarize the overall efficacy and safety of JAKi in various autoimmune conditions such as alopecia areata (AA), psoriasis vulgaris (PV), psoriatic arthritis (PsA), atopic dermatitis (AD), vitiligo, hidradenitis suppurative (HS), lichen planus (LP), and pyoderma gangrenosum (PG). Methods: A thorough review of articles was performed across PubMed and Google Scholar on meta-analyses, systematic reviews, clinical trials and case studies evaluating the treatment of autoimmune disorders such as AA, PV, PsA, AD, vitiligo, LP, HS, and PG with JAKi. Duplicated data and animal experiments or in vitro/ex vivo studies were excluded. Results: all the reviewed articles reported beneficial effects of tofacitinib and ruxolitinib application in the treatment of disorders mentioned above with the autoimmune predisposition. Conclusion: tofacitinib and ruxolitinib showed potential efficacy in treating several autoimmune disorders. Based on records in the reviewed studies, both medications had acceptable safety profiles; however, physicians are recommended to outweigh the risks and benefits of such treatments for each specific condition.
      PubDate: Mon, 31 Oct 2022 00:00:00 +000
       
  • Theory-Based Approaches to Support Dermoscopic Image Interpretation
           Education: A Review of the Literature

    • Authors: Tiffaney Tran; Niels K. Ternov, Jochen Weber, Catarina Barata, Elizabeth G. Berry, Hung Q. Doan, Ashfaq A. Marghoob, Elizabeth V. Seiverling, Shelly Sinclair, Jennifer A. Stein, Elizabeth R. Stoos, Martin G. Tolsgaard, Maya Wolfensperger, Ralph P. Braun, Kelly C. Nelson
      Abstract: Introduction: Efficient interpretation of dermoscopic images relies on pattern recognition, and the development of expert-level proficiency typically requires extensive training and years of practice. While traditional methods of transferring knowledge have proven effective, technological advances may significantly improve upon these strategies and better equip dermoscopy learners with the pattern recognition skills required for real-world practice. Objectives: A narrative review of the literature was performed to explore emerging directions in medical image interpretation education that may enhance dermoscopy education. This article represents the first of a two-part review series on this topic. Methods: To promote innovation in dermoscopy education, the International Skin Imaging Collaboration (ISIC)assembled a 12-member Education Working Group that comprises international dermoscopy experts and educational scientists. Based on a preliminary literature review and their experiences as educators, the group developed and refined a list of innovative approaches through multiple rounds of discussion and feedback. For each approach, literature searches were performed for relevant articles. Results: Through a consensus-based approach, the group identified a number of emerging directions in image interpretation education. The following theory-based approaches will be discussed in this first part: whole-task learning, microlearning, perceptual learning, and adaptive learning. Conclusions: Compared to traditional methods, these theory-based approaches may enhance dermoscopy education by making learning more engaging and interactive and reducing the amount of time required to develop expert-level pattern recognition skills. Further exploration is needed to determine how these approaches can be seamlessly and successfully integrated to optimize dermoscopy education.
      PubDate: Mon, 31 Oct 2022 00:00:00 +000
       
  • Eruptive non-melanoma skin cancers/squamous atypia following skin surgery.
           Report of two new cases, concise review of the literature with special
           emphasis on treatment options

    • Authors: Marco Adriano Chessa; Valentino Marino Picciola, Federica Filippi, Annalisa Patrizi, Cosimo Misciali, Bianca Maria Piraccini , Ignazio Stanganelli, Francesco Savoia
      Abstract: Multiple eruptive cutaneous non-melanoma skin cancers(NMSCs) have been reported to arise at the sites of skin surgery, including the area affected by the primary tumour and split thickness skin graft(STSG) donor and recipient sites. The aim of this study is to make a critical revision of the literature, analysing the clinical, histological features and outcomes of eruptive NMSCs after cutaneous surgery. Up to August 2021, according to our systematic review of the literature, we have collected 18 published articles and a total of 33 patients, including our two cases. The results of this review highlight five red flags that clinicians should consider: (i) lower and upper limbs represent the cutaneous site with the highest risk, representing 82.35% of the cases in the literature; (ii) the median time to onset of eruptive NMSCs that is approximately 6 weeks; (iii) primary NMSCs were completely excised with free margins on histologic examination in all cases of the literature, and therefore the eruptive NMSCs reported could not be considered recurrences; (iv) any surgical technique involves a risk to promote eruptive NMSCs; (v) treatment of eruptive NMSCs includes surgery or combined surgical and medical treatment. However, eruptive NMSCs recurrences are a real medical challenge and have always been treated combining surgical and medical treatment, with complete resolution in about one third of patients. In conclusion, even though the pathogenesis remains unclear, this review highlights 5 red flags which could support clinicians in the diagnosis and management of eruptive of NMSCs after skin surgery.
      PubDate: Mon, 31 Oct 2022 00:00:00 +000
       
  • The Use of Dermoscopy in the Delineation of Basal Cell Carcinoma for Mohs
           Micrographic Surgery

    • Authors: Noureddine Litaiem; Faten Hayder, Imene Benlagha, Manel Karray, Chedli Dziri, Faten Zeglaoui
      Abstract: Introduction: Several studies investigated the use of dermoscopy in the delineation of Basal cell carcinoma (BCC) for Mohs micrographic surgery (MMS) with conflicting results Objective: The purpose of this systematic review with meta-analysis was to evaluate the effectiveness of the use of dermoscopy-guided MMS in the treatment of BCC. Methods: We included all comparative studies including more than twenty-five cases. Cases of BCC treated using dermoscopy-guided MMS (or slow MMS) were compared to those treated with curettage-guided MMS or “standard” MMS. Results: A total of 6 studies including 508 BCCs were reviewed. There was no statistically significant difference in the proportion of total margin clearance on the first MMS stage between BCCs removed using dermoscopy-guided MMS and those that had curettage or visual inspection. However, lateral margin involvement was significantly lower in BCCs that had dermoscopy-guided MMS. Limitations: Scarcity of research on this subject Conclusions: Dermoscopy allows visualization of structures up to 1mm into the dermis, and therefore it is rational to use it for lateral margin evaluation. Currently, there are two comparative studies showing the efficacy of dermoscopy for lateral margin evaluation during MMS. Future studies are required to develop an evidence-based recommendation regarding the utility of dermoscopy in MMS.
      PubDate: Mon, 31 Oct 2022 00:00:00 +000
       
  • Apremilast in psoriasis patients with serious comorbidities: a case series
           and systematic review of literature

    • Authors: Aikaterini Tsentemeidou; Elena Sotiriou, Nikolaos Sideris, Katerina Bakirtzi, Ilias Papadimitriou, Aimilios Lallas, Dimitrios Ioannides, Efstratios Vakirlis
      Abstract: Introduction: Patients with serious comorbidities are traditionally excluded from clinical trials. Apremilast is not contraindicated in active infections, malignancy and serious hepatic or renal impairment, but real-life data is needed to support this recommendation. Objectives: The aim of this paper is to present our personal as well as literature-sourced real-world evidenced on apremilast use in psoriasis patients with serious baseline comorbidities. Methods: A case-series and systematic literature review were performed. The psoriasis archives of a tertiary-care hospital, four electronic databases (MEDLINE, ScienceDirect, Cochrane Library, Google scholar) and other sources were searched (2014 – July 2021). Identified records were considered eligible, if they reported on the use of apremilast monotherapy in psoriasis patients with chronic infections, history of malignancy, serious liver, renal, psychiatric, or other disease(s). Results: At least 841 psoriasis patients with serious baseline diseases received apremilast. Only 3 cases of cancer progression and no infection reactivations or worsening of other diseases were documented. No increased frequency / severity of adverse events or reduced drug efficacy were noted. Main limitations of this study are the exclusion of a few reports due to inappropriately documented data and the fact that at least some patients might have been counted more than once. Conclusions: Apremilast is a safe and adequately efficacious option for psoriasis that cannot be treated / is challenging to treat with classic systemic agents and/or biologics.
      PubDate: Mon, 31 Oct 2022 00:00:00 +000
       
  • Instructional Strategies to Enhance Dermoscopic Image Interpretation
           Education: A Review of the Literature

    • Authors: Tiffaney Tran; Niels K. Ternov, Jochen Weber, Catarina Barata, Elizabeth G. Berry, Hung Q. Doan, Ashfaq A. Marghoob, Elizabeth V. Seiverling, Shelly Sinclair, Jennifer A. Stein, Elizabeth R. Stoos, Martin G. Tolsgaard, Maya Wolfensperger, Ralph P. Braun, Kelly C. Nelson
      Abstract: Introduction: In image interpretation education, many educators have shifted away from traditional methods that involve passive instruction and fragmented learning to interactive ones that promote active engagement and integrated knowledge. By training pattern recognition skills in an effective manner, these interactive approaches provide a promising direction for dermoscopy education. Objectives: A narrative review of the literature was performed to probe emerging directions in medical image interpretation education that may support dermoscopy education. This article represents the second of a two-part review series. Methods: To promote innovation in dermoscopy education, the International Skin Imaging Collaboration (ISIC) assembled an Education Working Group that comprises international dermoscopy experts and educational scientists. Based on a preliminary literature review and their experiences as educators, the group developed and refined a list of innovative approaches through multiple rounds of discussion and feedback. For each approach, literature searches were performed for relevant articles. Results: Through a consensus-based approach, the group identified a number of theory-based approaches, as discussed in the first part of this series. The group also acknowledged the role of motivation, metacognition, and early failures in optimizing the learning process. Other promising teaching tools included gamification, social media, and perceptual and adaptive learning modules (PALMs). Conclusions: Over the years, many dermoscopy educators may have intuitively adopted these instructional strategies in response to learner feedback, personal observations, and changes in the learning environment. For dermoscopy training, PALMs may be especially valuable in that they provide immediate feedback and adapt the training schedule to the individual’s performance.
      PubDate: Mon, 31 Oct 2022 00:00:00 +000
       
  • Pigmented macules on the head and neck

    • Authors: Gracy Gouda; John Pyne , Tony Dicker
      Abstract: Introduction: Differentiating early melanoma from other flat pigmented lesions on the head and neck is challenging both clinically and dermoscopically, partly due to the wide differential diagnosis and the lack of specific diagnostic algorithms. Objectives: To review publications covering the dermoscopic features of pigmented macules on the head and neck. Methods: Embase and PubMed (Medline) database from Jan 2015 to Jan 2021 were searched using a four-step search. Keywords used were dermoscopy/dermatoscopy or epiluminescence microscopy, lentigo maligna (LM), lentigo maligna melanoma (LMM), lichen-planus-like-keratosis (LPLK), solar lentigo (SL), seborrhoeic keratosis (SK), pigmented actinic keratosis (PAK), pigmented Bowen’s disease (pBD), pigmented intraepidermal carcinoma (pIEC) and head and neck. Results: The commonest reported dermoscopic features of facial melanoma were irregular dots, atypical dots/globules, asymmetric pigmented follicular openings (APFO), rhomboid grey/ black structures, increased vascular network, brown globules/dots and a pattern of circles. Pseudopods, radial streaming, blue white veil, irregular blotches, scar-like depigmentation and atypical pigment network were recorded in low frequencies. For PAK, pBD and pIEC perifollicular erythema, white/yellow surface scale, linear wavy vessels around hair follicles, hair follicular openings surrounded by a white halo, evident follicles or follicular or keratotic plugs, rosette sign and sharply demarcated borders were the salient features. Conclusions: Further studies are needed to determine the dermoscopic criteria for pigmented melanocytic and non-melanocytic lesions on the head and neck. Furthermore, there is a gap in the knowledge of site-specific dermoscopic features on specific sites, namely ears, nose, cheeks, scalp and neck which will also benefit from further studies.
      PubDate: Mon, 31 Oct 2022 00:00:00 +000
       
  • SARS-CoV-2 Vaccination and Chilblain-like Lesions: What Do We Know So
           Far'

    • Authors: Taha Gul Shaikh; Summaiyya Waseem, Syed Hassan Ahmed, Nashwa Abdul Qadir, Vincenzo Piccolo
      Abstract: The coronavirus pandemic has caused massive damage to global health care and the economy. COVID-19 vaccination and following the government protocols is the only way to tackle this situation. The vaccination program has been paced around the globe to return as soon as possible to pre-COVID time. Although all the vaccines have been approved after the rigorous clinical and safety trials, some adverse effects have surfaced and are being reported from different parts of the world. One such side effect is chilblain-like lesions following the COVID vaccination. Chilblain lesions, also known as pernio, are an inflammatory condition usually affecting the acral regions of the body. It is mostly reported from cold and damp areas and has multiple causes associated with it. Reporting of such similar lesions has raised concern amongst the scientific community and has led to vaccine hesitancy amongst the general population. The exact mechanism behind these lesions is still unknown. Although the incidence of this condition is low, it still requires attention from the authorities. This study aims to review the publicly available data and to provide concise and comprehensive information on chilblain-like lesions post-COVID-vaccination.
      PubDate: Mon, 31 Oct 2022 00:00:00 +000
       
  • Lymphadenopathy after COVID-19 vaccine mimicking lymph-node progression in
           a patient with metastatic melanoma

    • Authors: Julia Verdaguer Faja; Josè Luis Manzano, Sofia España, Paula Cecilia Notta, Raul Vicente Rodriguez Iniesta, Aram Boada
      PubDate: Mon, 31 Oct 2022 00:00:00 +000
       
  • Unilateral Rosacea in a patient with multiple sclerosis

    • Authors: Mariem Tabka; Rima Gammoudi, Refka FRIOUI, Nedia Fetoui, Colandane Belajouza, Mohamed Denguezli
      Abstract: none
      PubDate: Mon, 31 Oct 2022 00:00:00 +000
       
 
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