Publisher: Mattioli 1885 srl (Total: 9 journals)   [Sort alphabetically]

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European J. of Oncology and Environmental Health     Open Access   (Followers: 8, SJR: 0.112, CiteScore: 0)
Progress in Nutrition     Open Access   (Followers: 2, SJR: 0.193, CiteScore: 0)
Acta Bio Medica     Open Access   (Followers: 1, SJR: 0.224, CiteScore: 1)
La Medicina del Lavoro     Partially Free   (Followers: 1, SJR: 0.299, CiteScore: 1)
Sarcoidosis Vasculitis and Diffuse Lung Diseases     Open Access   (Followers: 1, SJR: 0.765, CiteScore: 2)
Dermatology Practical & Conceptual     Open Access  
Confinia Cephalalgica et Neurologica     Open Access  
Medicina Historica     Open Access  
Mediterranean J. of Hematology and Infectious Diseases     Open Access   (SJR: 0.506, CiteScore: 1)
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Sarcoidosis Vasculitis and Diffuse Lung Diseases
Journal Prestige (SJR): 0.765
Citation Impact (citeScore): 2
Number of Followers: 1  

  This is an Open Access Journal Open Access journal
ISSN (Print) 1124-0490
Published by Mattioli 1885 srl Homepage  [9 journals]
  • Clinical significance of procalcitonin in critically ill patients with
           pneumonia receiving bronchoalveolar lavage

    • Authors: Yusheng Cheng; Lingling Li, Min Zhang, Yuqing Wei, Zhiwei Lu, Xiongwen Tu
      Abstract: Background: As a useful tool in intensive care units (ICU), fiberoptic bronchoscopy (FOB) may cause a deterioration of infection. This study is to investigate the clinical significance of procalcitonin (PCT) in critically ill patients with severe pneumonia receiving bronchoalveolar lavage (BAL).
      Methods: A retrospective case-control study was performed in a single respiratory ICU (RICU) with 6-bed. Critically ill patients with severe pneumonia admitted to RICU were consecutively reviewed from March 2017 to October 2019. Chi-square test, Wilcoxon test, Mann Whitney U-test, Kaplan–Meier survival analysis or Cox’s proportional hazards regression model was used as appropriate.
      Results: A total of 72 eligible patients were included in the final analysis, 51 of which received BAL performed by FOB. Serum levels of PCT in group received BAL is markedly increased at 24 hours after FOB (p<0.001). Forty-eight hours later, BAL group with decreased serum levels of PCT had less SOFA score and decreased mortality compared with those with increased serum levels of PCT. Furthermore, Kaplan-Meier analysis indicated that patients with decreased serum levels of PCT had improved survival rate during hospital (Breslow test, p=0.041). However, increased PCT after BAL was not an independent risk factor for in-hospital mortality (hazard ratio: 1.689, 95% CI[ 0.626 ,4.563], p=0.301).
      Conclusions: BAL performed by FOB increased serum levels of PCT. However, PCT levels decreased at 48 hours after BAL predicted a good prognosis of patients with severe pneumonia.  
      PubDate: Fri, 23 Sep 2022 00:00:00 +000
       
  • Routine laboratory biomarkers as prognostic indicators of cardiac
           sarcoidosis outcomes

    • Authors: Nikhil Kolluri; Tyler Schmidt, Mohamed Elwazir, Suraj Kapa, Omar AbouEzzeddine, John Bois, John Schirger, Andrew Rosenbaum, Leslie Cooper
      Abstract: Background: Biomarkers to monitor disease activity and predict major adverse cardiac events (MACE) in CS have not been described previously. We aimed to identify biomarkers to predict MACE in cardiac sarcoidosis (CS). Methods: Patients (N=232) diagnosed with CS were retrospectively enrolled. Biomarkers including angiotensin-converting enzyme (ACE), N-terminal brain natriuretic peptide (NT-proBNP), troponin T, and creatinine levels were evaluated against a primary end point of left ventricular assist device implantation, heart transplantation, or death, and a secondary end point of cardiac hospitalization-free survival. Results: Troponin T (hazard ratio [HR], 1.06 per 0.01 ng/mL; P=.006), NT-proBNP (HR, 1.31 per 1,000 pg/mL; P<.001), and creatinine (HR, 4.02 per mg/dL; P=.01) were associated with the primary end point, even after adjusting for ejection fraction. NT-proBNP, B-type natriuretic peptide (BNP), creatinine, albumin, and calcium were associated with the secondary end point (P<.05). ACE levels were associated with presence of late gadolinium enhancement (LGE) on cardiac magnetic resonance (CMR) imaging (mean difference, 14.7; P=.03); 1,25 dihydroxyvitamin D (1,25-OHVit-D) was associated with uptake on cardiac 18F-flurodeoxyglucose position emission tomography (FDG-PET, P=.03). Conclusions: Troponin T, NT-proBNP, and creatinine predict clinically significant outcomes in CS. ACE levels correlated with LGE on CMR, and 1,25-OHVit-D levels correlated with FDG-PET activity.
      PubDate: Fri, 23 Sep 2022 00:00:00 +000
       
  • Identifying a core outcome set for pulmonary sarcoidosis research – the
           Foundation for Sarcoidosis Research – Sarcoidosis Clinical OUtcomes
           Taskforce (SCOUT)

    • Authors: Nicola L. Harman; Sarah L. Gorst, Paula R. Williamson, Elliot S. Barnathan, Robert P. Baughman, Marc A. Judson, Heidi Junk; Nynke A. Kampstra; Eugene J. Sullivan, David E. Victorson, Marc K. Walton, Tamara Al-Hakim, Hana Nabulsi, Noopur Singh, Jan C. Grutters, Daniel A. Culver
      Abstract: Background Pulmonary sarcoidosis is a rare granulomatous disease of unknown aetiology. Heterogeneity in the outcomes measured in trials of treatment for pulmonary sarcoidosis has impacted on the ability to systematically compare findings, contributing to research inefficiency. The FSR-SCOUT study has aimed to address this heterogeneity by developing a core outcome set that represents a patient and health professional consensus on the most important outcomes to measure in future research for the treatment of pulmonary sarcoidosis. Research design and methods A systematic review of trial registries, narrative synthesis of published qualitative literature on the patient experience and results of a patient survey contributed to the development of a comprehensive list of outcomes that were rated in a two round online Delphi survey. The Delphi survey was completed by patients/carers and health professionals and the results discussed and ratified at an online consensus meeting. Results 259 patients/carers and 51 health professionals completed both rounds of the Delphi survey. A pre-agreed definition of consensus was applied and the results discussed at an online consensus meeting attended by 17 patients and 7 health professionals). Fifteen outcomes, across five domains (physiological/clinical, treatment, resource use, quality of life, and death), reached the definition of consensus and were included in the core outcome set. Conclusions The core outcome set represents a patient and health professional consensus on the most important outcomes for pulmonary sarcoidosis research. The use of the core outcome set in future trials, and efforts to validate its components, will enhance the relevance of trials to stakeholders and will increase the opportunity for the research to contribute to evidence synthesis.
      PubDate: Fri, 23 Sep 2022 00:00:00 +000
       
  • Rituximab experience from a single centre for patients with rheumatoid
           arthritis-related interstitial lung disease

    • Authors: Didem Sahin Eroglu; Anil Colaklar, Serdar Baysal, Murat Torgutalp, Asaf Baygul, Mucteba Enes Yayla, Serdar Sezer, Caglar Uzun, Ozlem Ozdemir Kumbasar, Tahsin Murat Turgay, Gulay Kinikli, Askin Ates
      Abstract: Objective. To demonstrate the effects of rituximab (RTX) in patients with rheumatoid arthritis-related interstitial lung disease (RA-ILD). Methods. A total of 165 patients who used RTX for the management of rheumatoid arthritis were retrospectively scrutinised. Among these, 26 patients diagnosed with RA-ILD were analysed (61.5% male, mean age at RTX infusion 61.4 ± 6.5 years). To evaluate the efficacy of RTX on lung response, patients with pulmonary function test results and/or thorax computed tomography (chest-CT) of pre- and post-RTX were compared. Disease progression was defined as either a decline of ≥10% in forced vital capacity (FVC) and/or a decline of ≥15% in diffusion capacity of carbon monoxide (DLCO), or an increase of parenchymal involvement on chest-CT images according to the radiologists’ assessment. Results. Among 26 patients, the most common radiologic pattern was usual interstitial pneumonia (42.3%), followed by non-specific interstitial pneumonia (38.5%). Data for lung response was available in 20 patients. Median pre- and post- RTX DLCO values were 71.0% (60.0-77.0) and 63.0% (47.0-74.0), respectively (p= 0.06). Median pre- and post-RTX FVC values were 74.0% (61.0-99.0) and 84.0% (63.0-100.0), respectively (p= 0.28). Overall, stabilization or regression of RA-ILD was provided in 13 (65.0%) patients, whereas 7 patients had progressive RA-ILD. Post-RTX, 5 patients were diagnosed with RA-ILD. Conclusion. Our results suggest that RTX is effective in achieving stabilization or even improvement of RA-ILD. However, considering that it does not cause regression in every patient and some develop RA-ILD under RTX, we still need more effective treatment options.
      PubDate: Fri, 23 Sep 2022 00:00:00 +000
       
  • Pulmonary sarcoidosis with lung injury induced by shin’iseihaito

    • Authors: Kentaro Suzuki; Yoshiro Kai, Masayuki Matsuda, Kazuhide Horimoto, Kazonori Iwai, Eriko Hamada, Yoshifumi Yamamoto, Masato Takano, Shigeo Muro
      Abstract: Sarcoidosis is a multisystemic granulomatous disease of unknown cause. A 72-year-old man with a history of cerebral infarction presented with dyspnea after 3 weeks of smoking cessation treatment with shin’iseihaito. He was referred and admitted to our hospital for further investigation and treatment. Chest computed tomography revealed a lung infiltrative shadow, primarily in bilateral upper lobes, and enlargement of mediastinal and bilateral hilar lymph nodes. First, drug-induced lung injury by shin’iseihaito was suspected; shin’iseihaito was discontinued. However, chest imaging findings did not improve. On day 7, bronchoalveolar lavage fluid revealed 90% macrophages, 5% lymphocytes, and an increased CD4/CD8 T-cell ratio. Transbronchial lung biopsy histological findings showed inflammatory infiltrate and noncaseating granuloma, and in ophthalmologic survey, bilateral panuveitis was observed. The drug lymphocyte stimulation test for shin’iseihaito was negative. These findings suggested the diagnosis of pulmonary sarcoidosis induced by shin’iseihaito. He was treated with systemic steroids, resulting in improvement in radiological findings. He was discharged on the 21st day. Follow-up chest X-ray images after discharge confirmed the absence of recurrence. Very few cases of pulmonary sarcoidosis with acute injury have been reported. To our knowledge, this is the first case report of pulmonary sarcoidosis induced by herbal medicines, such as shin’iseihaito. Pulmonary sarcoidosis and drug-induced lung injury should be considered as a differential diagnosis in lung injury shadow during the administration of herbal medicine including shin’iseihaito.
      PubDate: Fri, 23 Sep 2022 00:00:00 +000
       
  • Clarithromycin in post COVID-19 organizing pneumonia

    • Authors: Irfan Ismail Ayub; Dhanasekar Thangaswamy, Abdul Majeed Arshad, Chandrasekar Chockalingam, Lithya Kumari Sampath, Hariprasad Balakrishnan
      Abstract: An increasing number of patients are reporting with symptoms secondary to post COVID-19 pulmonary sequelae. Radiological findings in these patients include fibrotic lung disease, interstitial lung abnormalities, ground glass opacities, and organizing pneumonia (OP). Therapeutic options in these patients include steroids and anti-fibrotics. The majority of these patients have received steroid therapy for COVID-19 pneumonia, and may continue to receive it for post COVID-19 pulmonary sequelae, subjecting themselves to steroid related adverse effects. Cryptogenic organizing pneumonia (COP) responds well to steroid therapy. Alternatively, macrolide therapy has been successful in the treatment of both cryptogenic and secondary forms of OP. Compared to steroid therapy, macrolide therapy in COP is well tolerated and associated with fewer adverse events. We report two patients who were diagnosed with post COVID-19 OP and were treated with clarithromycin for three months. We believe that clarithromycin offers a potential therapeutic option in post COVID-19 organizing pneumonia.
      PubDate: Fri, 23 Sep 2022 00:00:00 +000
       
  • A case of nail sarcoidosis with rich clinical findings

    • Authors: Can Baykal; Zeynep Yılmaz, Tuğba Atcı
      PubDate: Fri, 23 Sep 2022 00:00:00 +000
       
  • The characteristics of Japanese guidelines on diagnosis and treatment of
           cardiac sarcoidosis compared with the previous guidelines

    • Authors: Fumio Terasaki; Kengo Kusano, Takatomo Nakajima, Yoshikazu Yazaki, Shin-ichiro Morimoto, Daniel A. Culver, Mitsuaki Isobe
      Abstract: Sarcoidosis in Japanese sarcoidosis is characterized by a high prevalence of cardiac involvement. In this regard, cardiac sarcoidosis (CS) continues to be an important focus of study among physicians caring for sarcoidosis in Japan. The Japanese Ministry of Health, Labor and Welfare (MHLW) and Japan Society of Sarcoidosis and other Granulomatous Disorders (JSSOG) have published clinical guidelines aiming to assist clinical practices. Recently, the Japanese Circulation Society (JCS) has published new clinical guidelines for the diagnosis and treatment of CS that contain several new insights compared to previously published guidelines in Japan and other countries.
      PubDate: Fri, 23 Sep 2022 00:00:00 +000
       
  • An unusual case of Takayasu arteritis presenting as acute myocardial
           infarction and ischaemic stroke

    • Authors: Mia Manojlovic; Sonja Golubovic, Tatjana Ilic, Filip Samardzic, Biljana Vuckovic, Dragana Tomic-Naglic, Ivana Bajkin, Sladjana Pejakovic
      Abstract: INTRODUCTION: Takayasu’s arteritis (TA) is well-known yet rare disorder, defined as a chronic large vessel vasculitis mainly involving the aorta and its major branches. We present a complex case of a 51-year-old female patient who first presented with acute myocardial infarction as an initial manifestation of Takayasu arteritis, and later with an acute onset of ischemic stroke. CASE REPORT: We present a case of 51-year-old female patient who was admitted at the Clinic of Nephrology and Clinical Immunology. During hospitalization, a sudden onset of intense chest pain occurred, followed by a development of heart failure to the level of cardiogenic shock. Electrocardiography showed signs of ST-elevated myocardial infarction (STEMI) of the anterior wall, and an increase in cardiospecific enzymes. CT angiography indicated an occlusion of the left ACC, subclavian and axillary arteries as well as a penetrating aortic ulcer localized infrarenal. In the further course of treatment, left-sided weakness of the body was registered. Head CT scan showed an acute ischemic lesion high parietal on the right, as well as a chronic ischemic lesion on the front right. Doppler ultrasonography of carotid and vertebral arteries registered left occlusion, right ACC / ACE stenosis with suspected "macaroni sign". Final diagnosis of Takayasu arteritis was established and corticosteroids were included in the therapy (primarily in pulse doses) with the first pulse of cyclophosphamide of 1000mg. CONCLUSION: This disease should be considered in young female patients who present with chronic inflammation and acute coronary syndrome.
      PubDate: Fri, 23 Sep 2022 00:00:00 +000
       
  • Unusual bone localization of sarcoidosis mimicking metastatic lesions

    • Authors: Besma Hamdi; Emna Ben Jemai, Monia Attia, Ikbel Khalfallah, Hend Riahi, Anissa Berraies, Mohamed Faouzi Ladeb, Soumaya Rameh, Agnes Hamzaoui
      Abstract: Sarcoidosis is a multisystem disease of unknown origin. Diagnosis remains challenging, based on organ site involvement, histological confirmation of non-caseating granuloma and an appropriate clinical syndrome. Granulomatous bone involvement is rare and may be ignored because it is usually asymptomatic. Vertebrae, ribs and skull localizations are rarely reported. We described an interesting case of a woman with chronic and multiorgan sarcoidosis with unusual bone localizations.
      PubDate: Fri, 23 Sep 2022 00:00:00 +000
       
  • Tackling Health Care Disparities: How to Build a Sarcoidosis Center

    • Authors: Jordana Kron; Aamer Syed, Thomas Iden, Kelly Gwathmey, Kelly Polly, Jessica Randolph, Vikram Brar, Patrick Nana-Sinkam, Kenneth Ellenbogen, Huzaefah Syed
      Abstract: Sarcoidosis is a multi-organ system inflammatory disease of unknown etiology that disproportionately affects women and black patients in the United States. In addition, woman and minority patients have worse outcomes. In 2015, sarcoidosis physicians in cardiology, pulmonary medicine and rheumatology joined forces to create a multidisciplinary sarcoidosis at Virginia Commonwealth University.  In 2019, the clinic was recognized as a World Association of Sarcoidosis and Other Granulomatous Disorders (WASOG) Center of Excellence. We identify four pillars of a patient-centered sarcoidosis clinic: clinical care, research, teaching, and community outreach. We detail how each of these facets plays a critical role in improving the health of individual patients, creating a strong infrastructure to improve the future of sarcoidosis treatment, and developing community-based resources that can empower patients.  Most importantly, we highlight how a multidisciplinary clinic can help identify and combat healthcare disparities.  
      PubDate: Fri, 23 Sep 2022 00:00:00 +000
       
 
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