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Journal of Cancer Research and Treatment
Number of Followers: 3

This is an Open Access Journal

Open Access journal
ISSN (Print) 2374-1996 - ISSN (Online) 2374-2003
Published by Science and Education Publishing

[75 journals]

Impact of miRNA Alteration on Cancer Pathogenesis
- Authors: Emmanuel Atiatorme; Richard Osafo
  Pages: 1 - 11
  Abstract: MicroRNAs (miRNAs) are a type of non-coding RNA that controls gene expression post-transcriptionally through either translational repression or mRNA degradation. By regulating the translation of oncogenes and tumor suppressor genes, altered miRNA expression is linked to the development and progression of numerous human malignancies. Cleavage and translational modification of target proteins are some possible ways that miRNA affects target gene expression. MiRNAs are increasingly becoming recognized as critical regulators of biological processes such as differentiation, embryonic development, cell cycle, proliferation, apoptosis, stress resistance, fat metabolism, immunological defense, virus-related illnesses, and, most crucially, carcinogenesis. On the other hand, they appear to be key prognostic markers in patients with a variety of cancers, and they could be used as therapeutic tools. The current review focuses on recent findings in this fascinating new field of research, with a particular focus on the role of miRNA alterations in cancer pathogenesis. We explained how miRNA expression is altered in cancer at both the transcriptional and post-transcriptional levels, and how this elucidates some abnormal miRNA expression in cancer as well as some potential treatment controls for carcinogenesis. Our findings revealed that some miRNAs have evolved unique features and roles that control other transcriptional or posttranscriptional silencing pathways, resulting in carcinogenesis. The dynamic aspect of miRNA-based control in complex regulatory networks is highlighted by the evolution of miRNA processing and functional diversity. This review will aid in understanding how miRNA dysregulation affects cancer cell formation, as well as the development of more effective and secure miRNA-based therapies.
  PubDate: 2022-03-11
  DOI: 10.12691/jcrt-10-1-1
  Issue No: Vol. 10, No. 1 (2022)
Evaluation of Platelet Rich Plasma Enhanced Lipoinjection for Correction
- Authors: Ahmed Saad; Medhat Anwar, Rabie Ramadan, Hajer Hassan
  Pages: 12 - 22
  Abstract: Background: Lipofilling has become a widely used procedure in breast delayed reconstruction, after mastectomy, or breast conservative therapy, or autologous flap reconstruction. Main limitation is high reabsorption rate and local complications. The aim of this study is to evaluate the possible enhancement of the lipoinjectate to overcome these limitations. Methods: Between years 2017 and 2021, patients with PRP-enhanced lipofilling (Coleman technique) for correction (delayed) of different deformities after different surgical procedures used for breast cancer, (+-6 months after radiotherapy). Results: We performed the technique Platelet Rich Plasma enhanced lipoinjection after different surgical procedures used for breast cancer for 50 females, in which 20 patients underwent previous Breast Conservative therapy, 14 patients underwent modified radical mastectomy, and 16 patients had autologous flap reconstruction. Duration of operation 60-260 minutes, oil cysts 4%, fat necrosis 18%, microcalcifiaction 2%, absorption rate 31%, patient satisfaction (very satisfied) 42%. Conclusion: Although further investigations at the cellular level are needed, the results support the fact that PRP enhances the lipoinjectate subjectively, with lesser reabsorption rate and complications.
  PubDate: 2022-05-17
  DOI: 10.12691/jcrt-10-1-2
  Issue No: Vol. 10, No. 1 (2022)

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