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Journal of Cancer Research and Treatment
Number of Followers: 4

This is an Open Access Journal

Open Access journal
ISSN (Print) 2374-1996 - ISSN (Online) 2374-2003
Published by Science and Education Publishing

[75 journals]

Resistance to Anticancer Agents: Recent Trends
- Authors: Ahmed M. Kabel; Maaly A. Abd Elmaaboud
  Pages: 11 - 14
  Abstract: Resistance to the anticancer agents is a complex process that mainly results from alteration in the targets of the chemotherapeutic agents. Mechanisms that underlie resistance to the anticancer agents include inactivation of the drug, inhibition of cellular apoptosis, changes in the metabolic pathways of the drug, increased expression of the efflux proteins and enhancement of DNA repair and gene amplification. Several strategies were developed to overcome this resistance. The use of the combination chemotherapy is the best option for drug resistant types of cancer. This review throws light on resistance of cancer cells to the chemotherapeutic agents in view of the recent trends.
  PubDate: 2020-06-02
  DOI: 10.12691/jcrt-8-2-1
  Issue No: Vol. 8, No. 2 (2020)
A Prospective Observational Study of the Correlation between Hormone
Receptor Status and Other Prognostic Factors in Carcinoma Breast in a
Rural Set Up in Central India
- Authors: Raju Gore; Tanweerul Huda, Bharati Pandya
  Pages: 15 - 20
  Abstract: Breast cancer is a major concern in modern India. The growing population of the patients and the increased death toll require immediate attention from the scientific and medical community. Patients¡¯ age, socio-economic condition, and disease awareness play vital roles in the disease onset and progression. In this study, we have conducted a rigorous survey between 2012 and 2014 and investigated all possible contexts in relevance to the disease. From socio-economic to clinical and histopathological relevance were explored. Detail analysis was done for 112 patients. Our data shows Indian scenario having differences not only in stage at presentation with poorer survival but also that the age at presentation is almost a decade earlier than western studies. Only 8% of the participant patients were found to be nulliparous. Very few patients (11.60%) were found to be linked with the disease hereditarily. Statistical co-relation was found between ER status, PR status, lymph nodes, and age of the patients. Our study has shown similarity with the earlier studies as well as dissimilarity in certain facts. We expect this study will increase the present understanding of breast cancer in India.
  PubDate: 2020-07-14
  DOI: 10.12691/jcrt-8-2-2
  Issue No: Vol. 8, No. 2 (2020)
Pituitary Adenomas: Insights into the Recent Trends
- Authors: Ahmed M. Kabel
  Pages: 21 - 24
  Abstract: Pituitary adenoma is a type of pituitary neoplasms that is typically a benign, slow-growing tumor that arises from cells in the pituitary gland. Pituitary adenomas are classified according to their secretory products into functioning (Endocrine-active) tumors that represent almost 70% of pituitary tumors, and non-functioning adenomas (Endocrine-inactive). Because of physiologic effects of excess hormones, the functioning tumors present earlier than non-functioning adenomas. Patients with pituitary adenomas usually present with symptoms related to hormonal disturbances. However, pressure symptoms, such as headache, visual field defects, cranial nerve palsies and hypopituitarism may occur due to the mass effect of large tumors. Treatment of pituitary adenomas include transsphenoidal surgery and adjunctive therapy including supervoltage radiation and pharmacologic agents. This review throws light on pituitary adenoma regarding its prevalence, predisposing factors, types, clinical presentation, diagnosis and possible lines of management in view of the recent trends.
  PubDate: 2020-09-09
  DOI: 10.12691/jcrt-8-2-3
  Issue No: Vol. 8, No. 2 (2020)
Anxiety and Pain Level Associated with Mammography and the Impact of the
Preexistence of Knowledge
- Authors: Faten Aldhafeeri; Manal Tharwat Abozeed
  Pages: 25 - 32
  Abstract: Background: Breast cancer is the most common type of cancer in women, after skin cancer. Early detection and treatment are recommended for reducing mortality and suffering. However, screening behaviors are often avoided for many reasons, such as anxiety and stress. Mammography screening is the main recommended test for the early detection of breast cancer. The objective of this study was to assess the knowledge, level of pain, and stress in women during the early screening of breast cancer with a mammogram. Materials and methods: This study has been approved by the Local Research Ethics Committee. The study was conducted at Hafr Elbatin Central Hospital in Saudi Arabi among 100 women. Data were collected via a structured interview questionnaire before and immediately after the mammography procedure. The questionnaire consisted of three parts: (1) sociodemographic data and knowledge about the mammogram examination, (2) pain scale, and (3) anxiety scale. Data were entered and analyzed using SPSS version 25. Results: A total of 75% (n=75) of the women reported moderate to severe pain during the mammogram examination. Up to 57% (n=57) of the women expressed severe anxiety about the mammogram procedure. Most of the women-85% (n=85)-were found to have poor knowledge related to mammograms and mammogram preparation. There was a strong correlation between pain before and during the mammogram procedure, P-Value (0.00001*) with Chi-squared (33.40) and a highly significant correlation between satisfactory and unsatisfactory knowledge in women's P-Value (0.00001*) with z test (6.57). A poor knowledge about breast cancer was detected in the overall studied women and those who had never undergone mammography, particularly knowledge related to the risk factors for breast cancer. The most important predictors of the barriers to mammography were incorrect beliefs about mammography and its procedures. Conclusion: Pain expectations can be approached in various ways to make the mammography experience much more tolerable for women, thereby encouraging them to attend and return for their scans. It was determined that women who had mammography had a moderate level of anxiety.
  PubDate: 2020-09-18
  DOI: 10.12691/jcrt-8-2-4
  Issue No: Vol. 8, No. 2 (2020)
Natural Plants and Cancer Therapy
- Authors: Ahmed M. Kabel
  Pages: 33 - 34
  Abstract: Cancer chemotherapy represents the cornerstone of management of a vast majority of neoplastic lesions. Adverse reactions of chemotherapy may affect the major body organs and represent deleterious health hazards for cancer patients. Recent studies are directed towards discovery of natural compounds of plant origin that have potential anticancer properties and may ameliorate the toxic effects induced by the traditional anticancer agents. This manuscript throws light on the potential role of the natural plants in cancer therapy.
  PubDate: 2020-09-25
  DOI: 10.12691/jcrt-8-2-5
  Issue No: Vol. 8, No. 2 (2020)

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