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American Journal of Pharmacological Sciences
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This is an Open Access Journal

Open Access journal
ISSN (Print) 2327-6711 - ISSN (Online) 2327-672X
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Larval and Acute Oral Toxicity of Calotropis Procera and Ficus Umbellata,
Plants Traditionally Used to Treat Hemorrhoids in Benin
- Authors: Yomakou Bato Georges G. René; Glinma Bienvenu, Assogba M. Fidèle, Akakpo Baï Huguette, Ahoton Djidénou, Ahounou Aïkpé Judith Fifamin, Yayi Ladekan Eléonore, Salomé D.S. Kpoviessi, Gbenou D. Joachim
  Pages: 28 - 34
  Abstract: In the modern days, investigation of the phytochemical compounds contained in the traditionally-acknowledged medicinal plants have established significant interest in drug research and developmental projects. In addition, phytochemical compounds in plants are compounds delivered by plants having pharmacological or toxicological properties in man and animals. Calotropis procera (Ait.) and Ficus umbellata (Vahl.) are two medicinal plants used in Benin. Their various preparations were used to treat a number of ailments and diseases, including hemorrhoids. Here, before checking their effects on hemorrhoids, toxicity studies were carried out on the decoction of F. umbellata leaves and those of C. procera with and without potash as used in the traditional treatment of hemorrhoids in Benin. Toxicity test results demonstrated tolerance of the leaves to Artemia salina larvae with all their LC50> 0.10 mg/mL (0.147 for extract of F. umbellata, 0.224 for extract without potash of C. procera and 0.887 for extract with potash of C. procera) and albino rats of the wistar strain in acute oral toxicity at a single dose of 2000 mg/kg body weight. Studies of chronic and sub-chronic toxicity, as well as the anti-inflammatory activity of the extracts, are in prospect.
  PubDate: 2023-10-07
  DOI: 10.12691/ajps-11-2-1
  Issue No: Vol. 11, No. 2 (2023)
Clinical Research Related Documents and Data Management: An Update
- Authors: Venkataramana Kandi; Sabitha Vadakedath
  Pages: 35 - 43
  Abstract: Clinical research is a way of doing research that is primarily aimed to solve a human health and/or ailment-related problem. However, clinical research is complex and involves factors that influence the accuracy of the study results. The clinical research-related documents and data management assumes increased significance. The data obtained from the clinical research is collected, stored, validated, distributed, analyzed, and managed according to standard recommendations as prescribed by the national and international regulatory agencies. The nature of the case record form, the data validation process, quality assurance during data collection, validation, database creation, pharmacovigilance, the role played by the regulatory authorities, and other aspects of clinical trial data management are discussed comprehensively in this review.
  PubDate: 2023-10-17
  DOI: 10.12691/ajps-11-2-2
  Issue No: Vol. 11, No. 2 (2023)
Salidiuretic Effect and Diuretic Mechanism of Action of an Aqueous Extract
of Saccharum Officinarum Leaves (Poaceae) in Rats
- Authors: Irié bi jean séverin; Kouakou Assui Aude Ines, Kassi yomalan, Abo kouakou Jean-Claude
  Pages: 44 - 48
  Abstract: Saccharum officinarum L (Poaceae) is a plant whose leaves are used as a diuretic and in the traditional treatment of high blood pressure. This study aims to evaluate the salidiuretic effect of the aqueous extract of Saccharum officinarum (Esol) leaves and detect its mechanism of action in rats. The effect of the dose of 1000 mg / kg BW is compared to those of furosemide (40 mg / kg BW), Esidrex (25 mg / kg BW) and Aldactone (50 mg / kg BW) on the concentration of Na+, K+ and Cl- ions in 24-hour urine produced by rats placed on water overload. The results show that the 24-hour urinary volume increases significantly (p < 0.001) with Esol (16.22 ± 1.89 mL) as do the diuretics used compared to the control. The determination of Na+, K+ and Cl- ions in the urine of animals treated with Esol gives respective concentrations of 2.65 ± 0.34; 0.23 ± 0.05 mEq / L and 2.67 ± 0.253 mEq / L variations significantly close to those of Aldactone. The pH of urine obtained with Esol and reference diuretics is basic. The Na+ / K+ ratio of Esol (11.27) like that of Aldactone (10.63) is greater than 10.These parameters confirm that the aqueous extract of Saccharum officinarum leaves has salidiuretic properties acting as a sparing agent potassium just like (Aldactone). These results therefore justify the use of Saccharum officinarum leaves in traditional medicine.
  PubDate: 2023-11-15
  DOI: 10.12691/ajps-11-2-3
  Issue No: Vol. 11, No. 2 (2023)

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