Publisher: Ivy Union Publishing   (Total: 5 journals)   [Sort by number of followers]

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American J. of Cancer Case Reports     Open Access   (Followers: 4)
American J. of Cancer Science     Open Access   (Followers: 3)
American J. of Current Microbiology     Open Access   (Followers: 5)
American J. of Energy and Environment     Open Access   (Followers: 6)
American J. of Polymer Science & Engineering     Open Access   (Followers: 2)
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American Journal of Polymer Science & Engineering
Number of Followers: 2  

  This is an Open Access Journal Open Access journal
ISSN (Online) 2572-5734
Published by Ivy Union Publishing Homepage  [5 journals]
  • Localization matters in targeted protein degradation

    • Authors: Varun Jayeshkumar Shah; Ivan Đikić
      Pages: 1465 - 1466
      Abstract: Many factors influence the efficiency of targeted protein degradation induced by proteolysis targeting chimeras (PROTACs). In this issue of Cell Chemical Biology, Simpson et al. (2022) highlight the impact of subcellular localization. Their study elucidates that the protein of interest exhibits different amenability to PROTAC-mediated degradation at different cellular compartments.
      Citation: Cell Chemical Biology 29, 10 (2022)
      PubDate: 2022-10-20
      DOI: 10.1016/j.chembiol.2022.09.006
      Issue No: Vol. 29, No. 10 (2022)
  • Fishing for a balance: Toward promyelinating drug discovery

    • Authors: Hannah Y. Collins; Ben Emery
      Pages: 1467 - 1469
      Abstract: In this issue, Häberlein et al. demonstrate a role for GPR17 in regulating zebrafish oligodendrocyte differentiation. Zebrafish expressing a humanized GPR17 respond to modulators, which are inactive against the endogenous zebrafish receptor. These findings highlight the potential for humanized zebrafish as an in vivo platform for targeted remyelination drug screens.
      Citation: Cell Chemical Biology 29, 10 (2022)
      PubDate: 2022-10-20
      DOI: 10.1016/j.chembiol.2022.09.005
      Issue No: Vol. 29, No. 10 (2022)
  • Exploring the target scope of KEAP1 E3 ligase-based PROTACs

    • Authors: Guangyan Du; Jie Jiang, Nathaniel J. Henning, Nozhat Safaee, Eriko Koide, Radosław P. Nowak, Katherine A. Donovan, Hojong Yoon, Inchul You, Hong Yue, Nicholas A. Eleuteri, Zhixiang He, Zhengnian Li, Hubert T. Huang, Jianwei Che, Behnam Nabet, Tinghu Zhang, Eric S. Fischer, Nathanael S. Gray
      Pages: 1470 - 1481.e31
      Abstract: Du et al. explores a variety of bivalent KEAP1-recruiting degraders to assess the generality of KEAP as an E3 ligase for targeted protein degradation They found the targets easily degraded using a cereblon (CRBN)- or VHL-recruiting degrader were refractory to KEAP1-mediated degradation.
      Citation: Cell Chemical Biology 29, 10 (2022)
      PubDate: 2022-09-06
      DOI: 10.1016/j.chembiol.2022.08.003
      Issue No: Vol. 29, No. 10 (2022)
  • Target protein localization and its impact on PROTAC-mediated degradation

    • Authors: Luke M. Simpson; Lorraine Glennie, Abigail Brewer, Jin-Feng Zhao, Jennifer Crooks, Natalia Shpiro, Gopal P. Sapkota
      Pages: 1482 - 1504.e7
      Abstract: Simpson et al. interrogate how the subcellular context of a target protein influences its amenability to PROTAC-mediated degradation. Differentially localized proteins displayed varying levels of degradation using the same respective PROTACs, suggesting that the subcellular context of the target protein can influence the efficacy of PROTAC-mediated POI degradation.
      Citation: Cell Chemical Biology 29, 10 (2022)
      PubDate: 2022-09-07
      DOI: 10.1016/j.chembiol.2022.08.004
      Issue No: Vol. 29, No. 10 (2022)
  • A propeptide-based biosensor for the selective detection of Vibrio
           cholerae using an environment-sensitive fluorophore

    • Authors: Alicia A. DeColli; Isabel M. Koolik, Anna B. Seminara, Stavroula K. Hatzios
      Pages: 1505 - 1516.e7
      Abstract: Proteases are attractive biomarkers for diagnostic applications, but identifying peptide substrates specific to a targeted pathogen is challenging. DeColli et al. demonstrate that the propeptide domain of a secreted bacterial protease can be engineered into a cleavage-based biosensor of the cholera pathogen Vibrio cholerae.
      Citation: Cell Chemical Biology 29, 10 (2022)
      PubDate: 2022-10-20
      DOI: 10.1016/j.chembiol.2022.09.003
      Issue No: Vol. 29, No. 10 (2022)
  • Targeting telomerase reverse transcriptase with the covalent inhibitor
           NU-1 confers immunogenic radiation sensitization

    • Authors: Yue Liu; Rick C. Betori, Joanna Pagacz, Grant B. Frost, Elena V. Efimova, Ding Wu, Donald J. Wolfgeher, Tracy M. Bryan, Scott B. Cohen, Karl A. Scheidt, Stephen J. Kron
      Pages: 1517 - 1531.e7
      Abstract: Liu et al. use telomerase inhibitor NU-1 to further implicate TERT in promoting DNA repair and cell survival after radiation in vitro. In vivo, NU-1 sensitizes tumors to radiation not only by blocking DNA repair but also by potentiating an adaptive immune response that leads to tumor elimination.
      Citation: Cell Chemical Biology 29, 10 (2022)
      PubDate: 2022-10-06
      DOI: 10.1016/j.chembiol.2022.09.002
      Issue No: Vol. 29, No. 10 (2022)
  • Dimerization of β2-adrenergic receptor is responsible for the
           constitutive activity subjected to inverse agonism

    • Authors: Yonghoon Kwon; Do-Hyeon Kim, Min Gyu Jeong, Minh-Triet Hong, Soyeon Park, Yeonho Chang, Kai Zhou, Seung-Yeol Park, Jin Zhang, Sung Ho Ryu
      Pages: 1532 - 1540.e5
      Abstract: Kwon et al. visualized transient β2-AR dimerization in living cells. A significant amount of β2-AR dimers exist in the basal state, and these were disrupted by inverse agonists. Gαs proteins couple to the dimeric β2-AR in basal state, resulting in cAMP production. The formation of β2-AR dimers requires cholesterol on the plasma membrane.
      Citation: Cell Chemical Biology 29, 10 (2022)
      PubDate: 2022-09-26
      DOI: 10.1016/j.chembiol.2022.09.001
      Issue No: Vol. 29, No. 10 (2022)
  • Humanized zebrafish as a tractable tool for in vivo evaluation of
           pro-myelinating drugs

    • Authors: Felix Häberlein; Enrico Mingardo, Nicole Merten, Nina-Katharina Schulze Köhling, Philip Reinoß, Katharina Simon, Anna Japp, Bhuvaneswari Nagarajan, Ramona Schrage, Cecile Pegurier, Michel Gillard, Kelly R. Monk, Benjamin Odermatt, Evi Kostenis, Jesus Gomeza
      Pages: 1541 - 1555.e7
      Abstract: The identification of drugs that promote remyelination in patients with demyelinating diseases, such as multiple sclerosis, is in high demand. Häberlein et al. introduce a GPR17-humanized zebrafish as proof of principle that fosters in vivo identification of novel pro-remyelination compounds acting via targeted inhibition of human GPR17.
      Citation: Cell Chemical Biology 29, 10 (2022)
      PubDate: 2022-09-19
      DOI: 10.1016/j.chembiol.2022.08.007
      Issue No: Vol. 29, No. 10 (2022)
  • In vivo bioluminescence imaging of granzyme B activity in tumor response
           to cancer immunotherapy

    • Authors: Min Chen; Kaixiang Zhou, Sheng-Yao Dai, Sirimuvva Tadepalli, Preethi Bala Balakrishnan, Jinghang Xie, Fadi E.I. Rami, Tingting Dai, Liyang Cui, Juliana Idoyaga, Jianghong Rao
      Pages: 1556 - 1567.e6
      Abstract: Chen et al. report the first granzyme B-activated bioluminescent probe GBLI-2 for non-invasive, real-time, and longitudinal imaging in vivo. GBLI-2 imaging predicts therapeutic efficacy and correlates with the change in the population of PD-1 and granzyme B expressing CD8+ T cells in tumors.
      Citation: Cell Chemical Biology 29, 10 (2022)
      PubDate: 2022-09-13
      DOI: 10.1016/j.chembiol.2022.08.006
      Issue No: Vol. 29, No. 10 (2022)
  • Context-dependent regulation of ferroptosis sensitivity

    • Authors: Leslie Magtanong; Grace D. Mueller, Kevin J. Williams, Maximilian Billmann, Katherine Chan, David A. Armenta, Lauren E. Pope, Jason Moffat, Charles Boone, Chad L. Myers, James A. Olzmann, Steven J. Bensinger, Scott J. Dixon
      First page: 1568
      Abstract: (Cell Chemical Biology 29, 1–10.e1–e6; September 15, 2022)
      Citation: Cell Chemical Biology 29, 10 (2022)
      PubDate: 2022-10-20
      DOI: 10.1016/j.chembiol.2022.08.008
      Issue No: Vol. 29, No. 10 (2022)
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