Publisher: Universidade Federal do Rio Grande do Sul   (Total: 35 journals)   [Sort by number of followers]

Showing 1 - 35 of 35 Journals sorted alphabetically
Acta Scientiae Veterinariae     Open Access   (Followers: 3, SJR: 0.144, CiteScore: 0)
Austral : Brazilian J. of Strategy & Intl. Relations     Open Access   (Followers: 7, SJR: 0.208, CiteScore: 0)
Brasil/Brazil     Open Access   (Followers: 2)
Cadernos de Informática     Open Access  
Cadernos de Tradução     Open Access   (Followers: 1)
Cadernos do IL     Open Access   (Followers: 1)
Cadernos do Programa de Pós-Graduação em Direito - PPGDir./UFRGS     Open Access   (Followers: 1)
Cena     Open Access  
Ciencias Sociales y Religión/Ciências Sociais e Religião     Open Access  
Conjuntura Austral : J. of the Global South     Open Access   (Followers: 2)
Debate Terminológico     Open Access   (Followers: 1)
Drug Analytical Research     Open Access   (Followers: 1)
Em Questão     Open Access   (Followers: 2)
Estatística e Sociedade     Open Access   (Followers: 1)
Fineduca : Revista de Financiamento da Educação     Open Access   (Followers: 1)
Ícone: Revista Brasileira de História da Arte     Open Access   (Followers: 1)
Organon     Open Access   (Followers: 1)
Para Onde!?     Open Access  
Pesquisas em Geociências     Open Access  
Philia&Filia     Open Access   (Followers: 1)
Políticas Educativas : PolEd     Open Access   (Followers: 1)
Res Severa Verum Gaudium     Open Access   (Followers: 1)
Revista Brasileira de Estudos Africanos / Brazilian J. of African Studies     Open Access  
Revista Brasileira de Estudos da Presença     Open Access  
Revista Brasileira de Política e Administração da Educação     Open Access   (Followers: 1)
Revista Conexão Letras     Open Access   (Followers: 1)
Revista Contraponto     Open Access  
Revista da Faculdade de Direito da UFRGS     Open Access  
Revista do Instituto Histórico e Geográfico do Rio Grande do Sul     Open Access  
Revista do Lhiste : Laboratório de Ensino de História e Educação     Open Access   (Followers: 1)
Revista Eletrônica de Direito Penal e Política Criminal     Open Access   (Followers: 1)
Revista Eletrônica de Iniciação Científica em Computação : REIC     Open Access  
Revista História da Educação - History of Education J.     Open Access   (SJR: 0.151, CiteScore: 0)
Revista Perspectiva : Reflexões Sobre a Temática Internacional     Open Access  
Revista Polis e Psique     Open Access  
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Drug Analytical Research
Number of Followers: 1  

  This is an Open Access Journal Open Access journal
ISSN (Print) 2527-2616
Published by Universidade Federal do Rio Grande do Sul Homepage  [35 journals]
  • Editorial Team

    • Authors: Drug Analytical Research
      Pages: 1 - 2
      PubDate: 2021-06-30
      Issue No: Vol. 5, No. 1 (2021)
  • Ozonized oils: a review of its quality control, stability and
           effectiveness in the treatment of Acne vulgaris

    • Authors: Gabriela Teixeira, Stacy Ondina, Alexandre Bella Cruz, Tania Mari Bellé Bresolin
      Pages: 3 - 13
      Abstract: Acne affects most young people and its topical treatment with antibacterials is associated with increased bacterial resistance to antibiotics and adverse effects. As an alternative, ozone therapy stands out through the application of ozonized oils. The objective of this work was to raise the scientific evidence about the effectiveness in the treatment of acne, in addition to the techniques of characterization and stability of ozonated oils. This is an exploratory, descriptive study with a quantitative approach, based on the analysis of scientific references in a bibliographic review of the expository type, of the last 20 years. Among the selected references, only four manuscripts reporting clinical studies of ozone therapy, with controversial results. Seven articles with the physicochemical characterization of ozonated oils were found. The major part of manuscripts reported the use of sunflower, sesame and olive oil. The more common techniques used to characterize the ozonation process are the peroxide value (PV) and the iodine index (Ii), which represents the proportion of unsaturated groups, whose values increase and decrease, respectively with ozonization progress. The viscosity of oils is increased by the formation of polymeric peroxides; the FTIR spectrum, which identifies the decrease in the stretch bands C = C, in addition to ozone formation, monitored by NMR, are also employed. Increased antimicrobial activity has been demonstrated with the ozone level of the oils, but the activity against Cutibacterium acne has not been reported. Only two article reported satisfactory stability for 6 months of refrigerated ozonized oil or kept at room temperature, showing the need for more specific research to support the application of ozonized oils in the treatment of acne and stability data of these products.
      PubDate: 2021-06-30
      Issue No: Vol. 5, No. 1 (2021)
  • Post mortem changes: challenges in drug analysis in the diagnosis of
           deaths from intoxication

    • Authors: Marina Camargo Galera, Luciana Grazziotin Rossato-Grando
      Pages: 14 - 18
      Abstract: In forensic toxicology, alternative matrices and sampling sites are required for a correlation of antemortem and postmortem concentrations with the least possible error. Postmortem redistribution phenomena and biochemical changes inherent to these processes are possible, and represent interferences in these analyses. This study aimed to perform a bibliographic review through Pubmed database within a 10-year period of time, using the keywords: forensic analysis AND redistribution. We observed that for quantitative analyses the preferred matrix is blood from peripheral vessels, and when it is not available, vitreous humor is a great specimen for choice. 
      PubDate: 2021-06-30
      Issue No: Vol. 5, No. 1 (2021)
  • Chlorine determination in medicinal plants by potentiometry with
           ion-selective electrode after microwave-induced combustion

    • Authors: Mariele Samuel Nascimento, Gabriel Toneto Druzian, Rochele Sogari Picoloto, Paola Azevedo Mello, Erico M. M. Flores
      Pages: 19 - 25
      Abstract: A method based on microwave-induced combustion (MIC) was applied for medicinal plants digestion allowing further chlorine determination by potentiometry using ion-selective electrode (ISE). Sample masses ranging from 500 to 1000 mg were evaluated for MIC digestion. Water and 10, 25, 50, and 100 mmol/L NH4OH were investigated as absorbing solutions. The accuracy of the proposed method was evaluated by using certified reference materials (CRMs), by recovery tests (500 µg/g), and also by comparison with the results obtained by inductively coupled plasma optical emission spectrometry (ICP-OES) after microwave-assisted alkaline extraction (MAE). Using water or NH4OH solutions (10 to 100 mmol/L), recoveries close to 100% and relative standard deviation lower than 5% were obtained. Results were in agreement with CRMs values (better than 95%) and also with those values obtained by using the MAE method. The main advantage of the proposed method was the complete combustion of high sample mass (1000 mg) resulting in low quantification limit (12.5 µg/g) and chlorine determination at low concentration by ISE. Another advantage of the proposed method was the high chlorine stability in digests (up to 30 days of storage) even using water as absorbing solution, which is in agreement with green analytical chemistry recommendations. Finally, the proposed MIC method was applied for commercial medicinal plants and the chlorine concentration was in the range of 59.4 ± 1.4 to 2038 ± 70 µg/g. The proposed MIC method was considered suitable for quality control for chlorine determination in medicinal plants.
      PubDate: 2021-06-30
      Issue No: Vol. 5, No. 1 (2021)
  • Phytochemical analysis using GC-FID, FPLC fingerprinting, antioxidant,
           antimicrobial, anti- inflammatory activities analysis of traditionally
           used Eucalyptus globulus essential oil

    • Authors: Arun Dev Sharma, Mohit Farmaha, Inderjeet Kaur, Narveer Singh
      Pages: 26 - 38
      Abstract: Eucalyptus globules is an widely distributed in tropical and subtropical regions. It has been widely used as folk medicine, and folk cosmetic owing to its antioxidant values. Despite its importance, phytochemical and pharmacological studies remain infancy. This study was aimed at extraction of essential oil by steam-distillation and evaluation of bioactive components, antioxidant, antimicrobial, anti-inflammatory activities along with analysis by UV-VIS, FT-IR and Fluorescent techniques. Fast protein liquid chromatography (FPLC) was used to confirm the presence of polyphenols. Different antioxidant activities like DPPH., ABTS.+, .OH, superoxide, nitric oxide and reducing power of the essential oil. Essential oil was analyzed by UV-VIS, FT-IR and Fluorescent techniques. In vitro antimicrobial activity was also monitored. FT-IR fingerprint qualitative analysis was performed using commercial standards. Considerable amount of flavonoids were detected in essential oil.  Oil exhibited considerable scavenging activities of ABTS.+, .OH, superoxide, nitric oxide and reducing power. UV-VIS, FT-IR analysis revealed the presence of polyphenolics in essential oil. Fluorescent spectroscopy revealed the presence of fluorophores in essential oil. FPLC and FT-IR fingerprint analysis revealed the presence of bioactive constituents like rutin, tannic acid, vanillic acid and ascorbic acid in the essential oil. A strong anti-inflammatory activity of oil was observed using fluorescent spectroscopy. An appreciable in vitro antibacterial activity against gram-negative bacteria like Acetobacter aceti and Pseudomonas aeruginosa was detected. The data provides the scientific support to the use of essential oil from Eucalyptus globules as a potent herbal source of bioactive compounds possessing natural antioxidant activities in food and pharmaceutical industries.
      PubDate: 2021-06-30
      Issue No: Vol. 5, No. 1 (2021)
  • A new and ecological miniaturized method by spectrophotometry for
           quantification of vancomycin in dosage form

    • Authors: Patrícia Nascimento, Ana Kogawa, Hérida Regina Nunes Salgado
      Pages: 39 - 45
      Abstract: Vancomycin, an important antibiotic, is marketed as lyophilized powder. In the context of routine analysis of this product, the existence of a more advantageous and effective method is interesting. Thus, the objective of this work is to develop and validate a new analytical method, faster, low-cost, ecological and miniaturized for quantification of vancomycin in lyophilized powder using spectrophotometry in ultraviolet region. Buffer solution pH 6.8, quartz cuvette with capacity of 700 µL and 280 nm were chosen. The method proved to be linear in the range of 50-150 µg/mL (0.9997). The selectivity of the method was proven in two ways: The standard-sample overlay aimed to identify vancomycin in the sample; The forced degradation test (sample solutions prepared in 0.01 M HCl, 0.01 M NaOH and aqueous conditions and kept at 60 ºC by 8 hours, and UV 254 nm at ambient temperature during 24 hours) aimed to show the susceptibility of the method to consequently indicate the stability of the sample. It was precise in intraday (RSD 1.27%), interday (RSD 1.18%) and between analysts (RSD 1.92%) levels. It was robust when small variations were performed in seven important parameters (wavelength, cuvette, filtration step, dibasic and monobasic phosphate brand, ultrasound time and source of water). The accuracy was proved by the standard recovery test and showed mean recovery of 101.10%. This method can be applied in routine analysis of quality control of vancomycin lyophilized powder and it is an effective, accessible and ecological alternative, which follows the Green Analytical Chemistry principles, presenting less waste generation, no use of toxic solvents, smaller sample volumes and required diluents, which impacts on the final cost of the analyzes.
      PubDate: 2021-06-30
      Issue No: Vol. 5, No. 1 (2021)
  • Development of derivative spectrophotometric method for simultaneous
           determination of pyrazinamide and rifampicin in cubosome formulation

    • Authors: Morgana Souza Marques, Fernando Dal Pont Morisso, Fernanda Poletto, Irene Clemes Külkamp Guerreiro
      Pages: 46 - 50
      Abstract: The ultraviolet spectrophotometry analysis for quantitative assay of drugs is a method accurate, sensitive, selective and reproductive with the advantage of being a simple and less expensive method. In this study, a derivative ultraviolet spectrophotometric method was developed for simultaneous determination of pyrazinamide (PYZ) and rifampicin (RIF). The spectrophotometric method was evaluated according to validation guidelines for specificity, linearity, limits of detection and quantification, precision, accuracy and robustness. The first-derivative spectra were obtained and by the zerocrossing point, the wavelength 247 nm and 365 nm were selected for PYZ and RIF quantification, respectively. No interference from cubosome excipients was detected in the proposed method. The results demonstrated linearity in a range of 4.0 – 12.0 µg/mL with an adequate correlation coefficient for both drugs. The intra and inter-day precision results (RSD < 5%) indicated the reproducibility of the method. The accuracy data showed satisfactory results (RSD < 5%) from recovery test. In addition, the robustness results showed that the PYZ and RIF content were unaffected by the solvent alteration of methanol to methanol:water (99:1, v/v). The derivative ultraviolet spectrophotometric method proved to be an excellent strategy for simultaneous determination of PYZ and RIF.
      PubDate: 2021-06-30
      Issue No: Vol. 5, No. 1 (2021)
  • A novel sensitive colorimetric determination of catecholamine drug in
           dosage form via oxidative coupling reaction with MBTH and potassium

    • Authors: Safwan Ashour
      Pages: 51 - 58
      Abstract: A new and direct colorimetric method has been established for the determination of catecholamine (methyldopa, MD) in both pure form and in pharmaceutical formulations. The method is based on the oxidative coupling reaction of MD with 3-methyl-2-benzothiazolinone hydrazone hydrochloride monohydrate (MBTH) and potassium ferricyanide at pH 10.4 in aqueous medium to form an orange product that has a maximum absorption at 460 nm. Beer's law plot showed good correlation in the concentration range of 1.0−56.0 µg mL-1, with detection limit of 0.31 µg mL-1. Molar absorptivity for the above method was found to be 6.56×103 L mol-1 cm-1. All the measurements were carried out at 25 ± 1.0 °C, the formation constant (logKf) value of colored species is 9.48 and the standard free energy (DG‡) is − 54.09 KJ mol-1. This method was applied successfully to determination of MD in tablets and the results were compared with the USP method. Common excipients used as additives in tablets do not interfere in the proposed method. The method is accurate, precise and highly reproducible, while being simple, cheap and less time consuming and hence can be suitably applied for routine analysis of MD in bulk and dosage forms.
      PubDate: 2021-06-30
      Issue No: Vol. 5, No. 1 (2021)
  • Use of Box–Behnken design for optimization of compounded medication:
           acyclovir capsules report

    • Authors: Suelen da Silva Reis, Valdemir da Silva Quintanilha Junior, Gabriella da Silva Boto, Thalita Martins da Silva, Elizabeth Valverde Macedo, Carlos Augusto de Freitas Peregrino, Samanta Cardozo Mourão, Emeli Moura de Araújo
      Pages: 59 - 67
      Abstract: Campus compounding pharmacies play an important role in public health. Herpes simplex is one of the most common viral diseases in humans, which generates a great demand for acyclovir capsules in compounding pharmacy. It is well known that the formulation's components influence the effectiveness of the drug. The objective of this study is to show the applicability of Box-Behnken design in optimization of a compounded formulation and to evaluate the effect of excipients on dissolution and drug content in acyclovir 200 mg capsules produced at UFF´s University Pharmacy (FAU). The formulations were prepared and evaluated for average weight test, uniformity of dosage units and in vitro dissolution, while meeting pharmacopoeial specifications. A statistical analysis showed that sodium starch glycolate, Aerosil®, influences drug content and dissolution results. Magnesium stearate shows no influence on the dissolution at different concentrations but influences the assay results. A numerical optimization was applied to adjust the formulation variables based on the foresaid responses, accomplishing the best formulation that will be prepared and dispensed at FAU upon medical prescription.
      PubDate: 2021-06-30
      Issue No: Vol. 5, No. 1 (2021)
School of Mathematical and Computer Sciences
Heriot-Watt University
Edinburgh, EH14 4AS, UK
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