Publisher: CCSE   (Total: 43 journals)   [Sort by number of followers]

Showing 1 - 40 of 40 Journals sorted alphabetically
Applied Physics Research     Open Access   (Followers: 9)
Asian Culture and History     Open Access   (Followers: 12)
Asian Social Science     Open Access   (Followers: 5)
Cancer and Clinical Oncology     Open Access   (Followers: 9)
Computer and Information Science     Open Access   (Followers: 15)
Earth Science Research     Open Access   (Followers: 8)
Energy and Environment Research     Open Access   (Followers: 14)
Engineering Management Research     Open Access   (Followers: 6)
English Language and Literature Studies     Open Access   (Followers: 18)
English Language Teaching     Open Access   (Followers: 32)
Environment and Natural Resources Research     Open Access   (Followers: 6)
Environment and Pollution     Open Access   (Followers: 10)
Global J. of Health Science     Open Access   (Followers: 6, SJR: 0.416, CiteScore: 1)
Higher Education Studies     Open Access   (Followers: 68)
Intl. Business Research     Open Access   (Followers: 6)
Intl. J. of Biology     Open Access   (Followers: 1)
Intl. J. of Business and Management     Open Access   (Followers: 15)
Intl. J. of Chemistry     Open Access   (Followers: 10)
Intl. J. of Economics and Finance     Open Access   (Followers: 13)
Intl. J. of English Linguistics     Open Access   (Followers: 11)
Intl. J. of Marketing Studies     Open Access   (Followers: 13)
Intl. J. of Psychological Studies     Open Access   (Followers: 4)
Intl. J. of Statistics and Probability     Open Access   (Followers: 3)
Intl. Law Research     Open Access   (Followers: 1)
J. of Agricultural Science     Open Access   (Followers: 5)
J. of Education and Learning     Open Access   (Followers: 2)
J. of Educational and Developmental Psychology     Open Access   (Followers: 15)
J. of Food Research     Open Access   (Followers: 3)
J. of Geography and Geology     Open Access   (Followers: 12)
J. of Materials Science Research     Open Access   (Followers: 9)
J. of Mathematics Research     Open Access  
J. of Molecular Biology Research     Open Access   (Followers: 4)
J. of Plant Studies     Open Access   (Followers: 1)
J. of Politics and Law     Open Access   (Followers: 9)
J. of Sustainable Development     Open Access   (Followers: 25)
Mechanical Engineering Research     Open Access   (Followers: 20)
Modern Applied Science     Open Access   (Followers: 1)
Network and Communication Technologies     Open Access   (Followers: 4)
Public Administration Research     Open Access   (Followers: 2)
Review of European Studies     Open Access   (Followers: 13)
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Journal of Molecular Biology Research
Number of Followers: 4  

  This is an Open Access Journal Open Access journal
ISSN (Print) 1925-430X - ISSN (Online) 1925-4318
Published by CCSE Homepage  [43 journals]
  • Molecular Evaluation of HIV-1 HAART Efficacy, Comparison of TDF+3TC+EFV
           and AZT+3TC+NVP Regimens

    • Abstract: Context: The UNAIDS goal of ending the HIV epidemic by 2030 will be achieved primarily through the success of the three “95s” by 2030, and in particular the third “95 », which consists of achieving an undetectable viral load thanks to effective antiretroviral treatment. Achieving and maintaining viral suppression is the goal of ART and a good knowledge of the effectiveness of triple ARV therapies can help national HIV programs. Thus, the objective of this study was to evaluate and compare the effectiveness of the two ARTs, Tenovofir + Lamivudine +Efavirenz (TDF+3TC+EFV) and Zidovudine+Lamivudine+ Efavirenz (AZT+3TC+NVP) in their abilities to make the plasma viral load of HIV+ patients under treatment undetectable. Material and method: This is a retrospective study of the management of HIV-1 seropositive patients, followed at the Military Hospital of Ouakam (HMO) Molecular Biology laboratory from 2014 to 2021. The main criterion for evaluating the effectiveness of the treatment was the proportions of patients whose Viral load values were undetectable, VL< 50 copies/ml depending on duration of antiretroviral therapy (ART). Plasma viral load tests were carried out on Abbott Real Time HIV-1® (m2000sp/rt) and COBAS®AmpliPrep/COBAS®TaqMan® (Roche) version 2.0. Variables with p1000 copies/ml) was significantly greater in patients taking AZT+3TC+NVP (13% versus 7.2%) after 18 months (P=0.001). Gender and age had a significant relationship in treatment success.Conclusion: TDF+3TC+EFV was superior in terms of virological suppression at the end of the study period. These results support the WHO recommendation to use TDF+3TD+EFV as an alternative first-line regimen.
      PubDate: Thu, 23 Nov 2023 01:52:45 +000
       
  • Cytosol-Exposed Lysine Residues Affect the Cytosol-Membrane Distribution
           and Serine-129 Phosphorylation of Alpha-Synuclein

    • Abstract: Familial Parkinson’s disease and other neurodegenerative diseases known as synucleinopathies are strongly associated with α-Synuclein (αS) missense mutations. One of these mutations, E46K, had been hypothesized to increase the electrostatic attraction of αS to neuronal vesicle membranes due to positively charged lysine that attracts negatively charged phospholipid head groups. Here, we confirm the biochemical mechanism of E46K through four compound mutants, each with three replacements with lysine on a cytosol-exposed position of the αS alpha helix. We show that the cytosolic αS to membrane-bound αS ratios are significantly lower, and that the phosphorylation rates of serine-129-a pathological marker-are pronouncedly higher for the mutants than for wild type. This experiment addresses the previous knowledge gap in the understanding of basic amino acid replacements in cytosol-exposed positions of αS. Importantly, the validated effect of cytosol-exposed lysine residues has implications for exploring the mechanism of pathogenesis of αS mutants in familial Parkinson’s disease.
      PubDate: Sun, 22 Jan 2023 02:41:00 +000
       
 
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Publisher: CCSE   (Total: 43 journals)   [Sort by number of followers]

Showing 1 - 40 of 40 Journals sorted alphabetically
Applied Physics Research     Open Access   (Followers: 9)
Asian Culture and History     Open Access   (Followers: 12)
Asian Social Science     Open Access   (Followers: 5)
Cancer and Clinical Oncology     Open Access   (Followers: 9)
Computer and Information Science     Open Access   (Followers: 15)
Earth Science Research     Open Access   (Followers: 8)
Energy and Environment Research     Open Access   (Followers: 14)
Engineering Management Research     Open Access   (Followers: 6)
English Language and Literature Studies     Open Access   (Followers: 18)
English Language Teaching     Open Access   (Followers: 32)
Environment and Natural Resources Research     Open Access   (Followers: 6)
Environment and Pollution     Open Access   (Followers: 10)
Global J. of Health Science     Open Access   (Followers: 6, SJR: 0.416, CiteScore: 1)
Higher Education Studies     Open Access   (Followers: 68)
Intl. Business Research     Open Access   (Followers: 6)
Intl. J. of Biology     Open Access   (Followers: 1)
Intl. J. of Business and Management     Open Access   (Followers: 15)
Intl. J. of Chemistry     Open Access   (Followers: 10)
Intl. J. of Economics and Finance     Open Access   (Followers: 13)
Intl. J. of English Linguistics     Open Access   (Followers: 11)
Intl. J. of Marketing Studies     Open Access   (Followers: 13)
Intl. J. of Psychological Studies     Open Access   (Followers: 4)
Intl. J. of Statistics and Probability     Open Access   (Followers: 3)
Intl. Law Research     Open Access   (Followers: 1)
J. of Agricultural Science     Open Access   (Followers: 5)
J. of Education and Learning     Open Access   (Followers: 2)
J. of Educational and Developmental Psychology     Open Access   (Followers: 15)
J. of Food Research     Open Access   (Followers: 3)
J. of Geography and Geology     Open Access   (Followers: 12)
J. of Materials Science Research     Open Access   (Followers: 9)
J. of Mathematics Research     Open Access  
J. of Molecular Biology Research     Open Access   (Followers: 4)
J. of Plant Studies     Open Access   (Followers: 1)
J. of Politics and Law     Open Access   (Followers: 9)
J. of Sustainable Development     Open Access   (Followers: 25)
Mechanical Engineering Research     Open Access   (Followers: 20)
Modern Applied Science     Open Access   (Followers: 1)
Network and Communication Technologies     Open Access   (Followers: 4)
Public Administration Research     Open Access   (Followers: 2)
Review of European Studies     Open Access   (Followers: 13)
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School of Mathematical and Computer Sciences
Heriot-Watt University
Edinburgh, EH14 4AS, UK
Email: journaltocs@hw.ac.uk
Tel: +00 44 (0)131 4513762
 


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