Publisher: Tehran University of Medical Sciences   (Total: 21 journals)   [Sort by number of followers]

Showing 1 - 28 of 28 Journals sorted alphabetically
Academic J. of Surgery     Open Access   (Followers: 18)
Acta Medica Iranica     Open Access   (SJR: 0.34, CiteScore: 1)
Current J. of Neurology     Open Access   (SJR: 0.415, CiteScore: 1)
Dermatology and Cosmetic     Open Access   (Followers: 5)
Frontiers in Emergency Medicine     Open Access   (Followers: 8)
Hematology/Oncology and Stem Cell Therapy     Open Access   (Followers: 6, SJR: 0.532, CiteScore: 1)
Hospital     Open Access   (Followers: 2)
Intl. J. of Hematology-Oncology and Stem Cell Research     Open Access   (Followers: 2, SJR: 0.56, CiteScore: 1)
Intl. J. of Hospital Research     Open Access  
Intl. J. of Occupational Hygiene     Open Access   (Followers: 5)
Iranian J. of Allergy, Asthma and Immunology     Open Access   (SJR: 0.326, CiteScore: 1)
Iranian J. of Health and Environment     Open Access  
Iranian J. of Microbiology     Open Access   (SJR: 0.388, CiteScore: 1)
Iranian J. of Psychiatry     Open Access   (Followers: 2, SJR: 0.334, CiteScore: 1)
Iranian J. of Public Health     Open Access   (SJR: 0.33, CiteScore: 1)
J. of Air Pollution and Health (رتبه علمی- پژوهشی)     Open Access  
J. of Arthropod-Borne Diseases     Open Access   (SJR: 0.72, CiteScore: 2)
J. of Dental Medicine     Open Access   (Followers: 2)
J. of Dentistry of Tehran University of Medical Sciences     Open Access  
J. of Family and Reproductive Health     Open Access   (SJR: 0.21, CiteScore: 1)
J. of Medical Ethics and History of Medicine     Open Access   (Followers: 17, SJR: 0.327, CiteScore: 1)
J. of Pharmaceutical Care     Open Access   (Followers: 2)
J. of Tehran University Heart Center, The     Open Access   (SJR: 0.152, CiteScore: 0)
Medical J. of the Islamic Republic of Iran     Open Access   (Followers: 1, SJR: 0.364, CiteScore: 1)
Nanomedicine Research J.     Open Access   (Followers: 1)
Tehran University Medical J.     Open Access   (SJR: 0.139, CiteScore: 0)
Translational Research in Urology     Open Access   (Followers: 1)
Transport Phenomena in Nano and Micro Scales     Open Access  
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Hematology/Oncology and Stem Cell Therapy
Journal Prestige (SJR): 0.532
Citation Impact (citeScore): 1
Number of Followers: 6  

  This is an Open Access Journal Open Access journal
ISSN (Print) 1658-3876 - ISSN (Online) 2589-0646
Published by Tehran University of Medical Sciences Homepage  [21 journals]
  • Incidence and Prognostic Impact of WT-1 Gene Exon7 and 9 Mutations in
           Acute Promyelocytic Leukemia

    • Authors: Fatemeh Nejatifar, Shahrbano Rostami, Barham Chahardouli, Amir Kasaeian, Mohammad Vaezi, Hossein Kamranzadeh, Seied Asadollah Mousavi, Kamran Alimoghaddam, Ardeshir Ghavamzadeh
      Pages: 74 - 80
      Abstract: Background: Wilms’ tumor gene 1 (WT1) gene mutation has been reported to be a prognostic factor in normal-cytogenetic acute myeloid leukemia (AML) patients. Higher rates of mutation in the WT1 gene have been reported in several tumors including normal-cytogenetic AML patients. Data regarding WT1 mutations in acute promyelocytic leukemia (APL) is very scarce. In this study, we evaluated the incidence and impact of WT1 mutation on the outcome of APL patients. Materials and Methods: A total of 92 patients diagnosed with APL were studied in three distinct groups: early mortality, relapsed, and persistent complete remission. Genomic DNA of bone marrow samples of patients was analyzed. For quantification of expression levels of the WT1 gene, real-time quantitative PCR (rqPCR) was performed by a real-time PCR system. WT1 mutation and its impact on prognosis were considered the primary endpoint of the study. Statistical analysis was performed with STATA. Results: WT1 mutation frequency was 6.25% in the early mortality group (1/16 patients), 13.16% in the relapse group (5/38 patients), and 7.89% in the persistent complete remission group (3/38 patients). 8 mutations were in exon 7 and one mutation in exon 9. WT1 mutation in the relapse group was associated with a trend toward worse disease-free survival (DFS) while overall survival (OS) was not affected by WT1 mutation in univariate analysis. Patients with no mutations in WT1 and FLT3/ITD had better overall survival and disease-free survival compared to patients with mutations in the WT1 gene or FLT3/ITD in the relapse group. Conclusion: The frequency of WT1 gene mutations does not differ significantly between patients with early mortality, relapse, and persistent complete remission. The presence of WT1 mutation is associated with higher relapse and lower survival rates in relapse group patients.      
      PubDate: 2022-04-03
      DOI: 10.18502/ijhoscr.v16i2.9199
      Issue No: Vol. 16, No. 2 (2022)
  • The Diagnostic Value of Ultrasound-Guided Cervical Core Needle Biopsy in
           Diagnosis of Lymphoma in Suspected Patients

    • Authors: Mohammad Ali Kazemi, Farzad Yazdani, Hashem Sharifian, Keyvan Aghazadeh, Behnaz Moradi, Hengameh Behravan, Mohsen Mikelani
      Pages: 81 - 85
      Abstract: Background: Core needle biopsy (CNB) guided by imaging modalities seems to be an acceptable modality for diagnosis of lymphoma due to its safety, good applicability, availability as well as diagnostic accuracy, however; Studies have not reached a consensus on its diagnostic accuracy and factors affecting its performance. The present study aimed to assess the value of ultrasound-guided cervical CNB in the diagnosis of lymphoma in suspected patients. Materials and Methods: This cross-sectional study was performed on 46 consecutive patients (20 to 82 years) with cervical mass or lymphadenopathy suspected of lymphoma and were candidates for diagnostic evaluation. Ultrasound-guided core needle biopsies (UGCNB) were done by a single radiologist under guided ultrasonography. The diagnostic value of UGCNB in the diagnosis and determination of specific lymphoma subtypes was assessed. Results: Using UGCNB led to the diagnosis of lymphoma in 34.8% and non-lymphoma lesions in 43.5%, while the diagnosis remained unclear in other 21.7% with a total UGCNB-based identification rate of 78.3%. No patient with lymphoma was missed. All patients were followed up over a 6-month period. In none of the cases, clinical diagnosis and treatment response were found contrary to the initial pathologic diagnosis. No significant complication such as hematoma or infection was reported. Conclusion: UGCNB has a high diagnostic value for determining the nature of the cervical lesions suspected of lymphoma. 
      PubDate: 2022-04-03
      DOI: 10.18502/ijhoscr.v16i2.9200
      Issue No: Vol. 16, No. 2 (2022)
  • Pediatric Cancer Registry at MAHAK Pediatric Cancer Treatment and Research
           Center: A Single-Center Study from Iran

    • Authors: Mohammad Faranoush, Narjes Mehrvar, Yasaman Sadeghi, Maryam Tashvighi, Mardawig Alebouyeh, Azim Mehrvar
      Pages: 86 - 93
      Abstract: Background: The childhood cancer registry in Iran is a hospital-based system and there is not any unique and national registry system for pediatric malignancies in Iran. According to the limitations and requirements, this study was designed to clarify the aspect of childhood malignancies in Iran and promote establishing the Iranian national childhood cancer registry system.  Materials and Methods: This cross-sectional longitudinal study was implied on 1500 patients younger than 20-years old diagnosed with any malignancy and admitted at MAHAK Pediatric Cancer Treatment and Research Center (MPCTRC) from 2007 to 2014. Data collection was based on a validated questionnaire with three categories including demographic data, clinical data and type of malignancy, and outcomes. Collected data were analyzed using methods for qualitative and quantitative variables (P-Value < 0.05) by SPSS software version 22. The survival rate was calculated by the Kaplan-Meyer method.      Results: This study was implied on 1500 children with a mean age of 6.1 years old. The most common malignancy was acute leukemia (30.7%) followed by central nervous system tumors (27%). At the onset of starting treatment, the rate of conferring with relapse, metastasis, and secondary malignancies was 29%, 19.5%, and 1% respectively. In addition, 52 patients had bone marrow transplantation of whom, 14 cases died. Totally, 42% of patients died and the 3-years, 5-years, and 10-years overall survival rates were 67.7% ± 0.01, 60.3% ± 0.01, and 53.8% ± 0.01, respectively. Conclusion: Establishing a population-based pediatric cancer registry in Iran is necessary and will be useful for improving the survival rate of mentioned patients.   
      PubDate: 2022-04-03
      DOI: 10.18502/ijhoscr.v16i2.9201
      Issue No: Vol. 16, No. 2 (2022)
  • Clinical and Pathological Features of Double-Hit and Triple-Hit High-Grade
           B-Cell Lymphomas: A Retrospective Study from Three Portuguese Tertiary

    • Authors: Rui Almeida, Carlos Abrantes, Davide Gigliano, Rui Caetano Oliveira, Paulo Teixeira, Marta Viegas, Ângelo Rodrigues, Maria José Julião
      Pages: 94 - 102
      Abstract:    Background: High-grade B-cell lymphoma (HGBL) with rearrangements of MYC and BCL2 and/or BCL6, called double and triple-hit lymphomas (DTH-HGBL), are lymphoid malignancies with inferior outcomes when treated with standard chemotherapy. The identification of DTH-HGBL cases is challenging, considering their variable clinical, morphologic, and immunohistochemical features. Materials and Methods: Retrospective revision of medical data of patients diagnosed with DTH-HGBL confirmed by FISH, between January 2010 and January 2020, in three Tertiary Portuguese Hospitals (Coimbra Hospital and University Center, Portuguese Oncology Institute – Coimbra and Portuguese Oncology Institute – Porto). Pathological features, morphology, and immunohistochemical profile were evaluated by at least two experienced pathologists in hematopoietic and lymphoid neoplasms. Results: The cohort included 24 patients: 33.3% triple-hit, 58.3%, MYC/BCL2 double-hit and 8.3% MYC/BCL6 double-hit. There was no gender predominance, with a median age of 62.5±14.3y, 33.3% were diagnosed as nodal disease and 66.7% as extranodal. Morphologic features of  DLBCL were present in 50% of cases, morphological features of both DLBCL and Burkitt lymphoma (DLBCL/BL) in 45.8% and 4.2% of blastoid morphology. Immunohistochemical evaluation, regarding the Hans algorithm, revealed a Germinal center (GC)/GC-like subtype in 83.3% of cases and a non-GC/non-GC-like subtype in 16.7%.  MYC was positive in 42.9% and the median proliferative index was 80±12.4%. Conclusion: DTH-HGBL has a very broad range of features. We consider that a cost-effective approach would be to perform cytogenetic analysis in DLBCL and DLBCL/BL cases with GC/GC-like subtype. MYC and BCL2 immunohistochemistry can be useful to identify patients who may benefit from more aggressive therapies, but not as tools for case selection for FISH.  
      PubDate: 2022-04-03
      DOI: 10.18502/ijhoscr.v16i2.9202
      Issue No: Vol. 16, No. 2 (2022)
  • Association between Perceived Stress and Neutropenia in Patients with
           Leukemia under Chemotherapy

    • Authors: Mohsen Esfandbod, Maryam Abazaria Tehrani, Maryam Haghshomar, Pantea Arya, Bahareh Shateri Amiri, Gholamreza Toogeh, Manoucheh Keyhani
      Pages: 103 - 110
      Abstract:   Background: The most prominent part of the cellular response of the immune system is driven by neutrophils. These cells tend to decline following chemotherapy in patients with leukemia. Neutropenia is an influential factor in the prognosis of cancer patients. Stress reduces white blood cells (WBC) and neutrophils leading to an increased risk of infectious diseases after chemotherapy. We investigated the association between neutropenia and perceived stress following chemotherapy. Materials and Methods: We performed a cross-sectional study on 60 patients with leukemia in a university hospital. Participants completed self-report measures including the demographic data and perceived stress scale (PSS) questionnaire. We compared rates of neutropenia, as a measure of chemotherapy prognosis, 10 days after chemotherapy in different stress levels. Moreover, the number of patients with polymorphonuclear (PMN) under 1000/microl was compared at different stress levels.    Results: We found that neutropenia is directly correlated with negative stress perception and inversely correlated with positive stress perception. These effects appear more prominent in patients with PMN under 1000/microl as the number of these patients was significantly more in groups with higher negative stress and less in groups with higher positive stress scores. Conclusion: It can be concluded that stress is correlated with neutropenia and stress management in patients with leukemia will be accompanied by better recovery outcomes and reduced risk of infectious disease.  
      PubDate: 2022-04-03
      DOI: 10.18502/ijhoscr.v16i2.9203
      Issue No: Vol. 16, No. 2 (2022)
  • Assessment the Effect of Human Umbilical Cord Wharton's Jelly Stem
           Cells on the Exprssion of Homing Genes; CXCR4 and VLA-4 in Cell Lline of
           Breast Cancer

    • Authors: Vida Vahdanikia
      Pages: 111 - 117
      Abstract: Background: Breast cancer is the most common cancer in women.  The prevalence of breast cancer in Western women is one in eight.  Although the prevalence of breast cancer in Iran is lower than in Western countries (one in every 10-12 women), the incidence of breast cancer in it is 5-10 years earlier than in Western countries. Breast cancer is the second leading cause of cancer death among women after lung cancer. Therefore, finding new therapeutic methods could potentially help to reduce breast cancer mortality and increase the survival rate. Wharton jelly stem cells with mesenchymal morphology play an important role in inhibiting the progression of ovarian, osteosarcoma, and breast cancer by inducing apoptoses and reducing metastasis. Several environmental and genetic factors are involved in the occurrence of breast cancer. CXCR4 and VLA-4 genes are important genetic factors in breast cancer that play a role in cell survival, migration, proliferation and metastasis of several types of cancer, especially breast cancer. Therefore, inhibition of these two genes by Wharton's Jelly Stem Cells could be a novel and effective therapeutic target in breast cancer.  The aim of this study was to investigate the effect of Wharton jelly stem cells secretion on the expression of CXCR4 and VLA-4 genes in cancer cells. Materials and Methods: These cells were exposed to Wharton's Jelly Stem Cells after culturing breast cancer cells. RNA was extracted from treated cells. The expression of CXCR4 and VLA-4 genes was evaluated by real-time PCR. Results: The results of the MTT and Scratching tests showed a significant difference compared to the control group. Also, the results of Real-time PCR showed a significant decrease in the expression of CXCR4 and VLA-4 genes compared to the control group. Conclusion: The results of this study showed that different concentrations of Wharton Jelly Stem Cells Reduce Cancer Cell Growth and Expression of CXCR-4 and VLA-4 Homing Genes in Breast Cancer Cell Line. Therefore, it can be considered that Wharton Jelly Stem Cells can be suggested as an effective treatment for breast cancer.
      PubDate: 2022-04-03
      DOI: 10.18502/ijhoscr.v16i2.9204
      Issue No: Vol. 16, No. 2 (2022)
  • Review SARS-CoV-2 Infection: A Possible Risk Factor for Incidence and
           Recurrence of Cancers

    • Authors: Abdollah Jafarzadeh, Rohit Gosain, Seyed Mohammad Javad Mortazavi, Maryam Nemati, Sara Jafarzadeh, Abbas Ghaderi
      Pages: 118 - 125
      Abstract: COVID-19 and malignancy can affect the susceptibility of one another. The lymphopenia-related immunosuppression, functional exhaustion of cytotoxic lymphocytes (such as T-cells and natural killer cells), hyperinflammatory responses, and perhaps reactivation of the latent oncogenic viruses may directly and/or indirectly play a role in the cancer development and recurrence in severe COVID-19 patients perhaps by breaking the altogether mechanisms of the immune-surveillance. SARS-CoV-2-infected malignant patients may be at higher risk of death of their cancer than SARS-CoV-2-uninfected patients with the same cancers. On the other side, patients with underlying cancer are highly vulnerable to SARS-CoV-2 infection compared with non-cancerous individuals, due to their immunocompromised state resulting from malignancy, chemotherapy, and other concomitant abnormalities. SARS-CoV-2-infected cancerous patients are unable to produce an effective anti-virus immune response and may exhibit more severe forms of COVID-19. This review described the possible impacts of SARS-CoV-2 infection on the development of cancer and cancer recurrence, and the potential cancer impacts on COVID-19 development, while the possible interventions are highlighted. 
      PubDate: 2022-04-03
      DOI: 10.18502/ijhoscr.v16i2.9205
      Issue No: Vol. 16, No. 2 (2022)
  • An Unusual Case of Hemolytic Anemia Reversed with Liver Transplantation

    • Authors: Vatsala Katiyar, Apaar Dadlani, Ishaan Vohra, Kamila Cisak, Ashutosh Barve
      Pages: 126 - 128
      Abstract: Spur cell anemia is acquired hemolytic anemia seen in patients with advanced liver disease, particularly in the setting of alcoholism, and warrants urgent liver transplant evaluation. We describe the case of a 58-year-old female with alcoholic cirrhosis who presented with worsening liver disease, profound anemia poorly responsive to blood transfusions, and multiple spur cells on the peripheral smear. She underwent a liver transplant, which led to the resolution of hematologic abnormalities and the need for transfusions. Our case highlights the significance of spur cell anemia as a harbinger of poor prognosis in patients with advanced liver disease and its reversibility with liver transplantation
      PubDate: 2022-04-03
      DOI: 10.18502/ijhoscr.v16i2.9206
      Issue No: Vol. 16, No. 2 (2022)
School of Mathematical and Computer Sciences
Heriot-Watt University
Edinburgh, EH14 4AS, UK
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