Abstract: Background and Objective: Nevus Comedonicus (NC) is a rare benign hamartoma presenting with grouped, dark, firm, comedo-like papules sometimes forming pustules and cysts, commonly seen on face and neck areas. The authors report a case of a 16-year-old female with lesions consistent with NC on biopsy. There was no extra cutaneous involvement since infancy when the lesions first appeared. Materials and methods: The patient was treated with adapalene 0.3% gel, twice a day and oral doxycycline 100 mg/cap, twice a day for one month. Results: There was a decrease in the size of cysts and improvement in the depth of the pits; however, the formation of comedo-like papules remained unchanged. Conclusion: To date, there have been no published studies of the use of topical adapalene in NC. In addition, the combined treatment of topical adapalene and oral doxycycline has not been previously reported in the literature. PubDate: 13 November, 2021
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